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MOXD2P Gene

pseudogene   GIFtS: 25
GCID: GC07M141942

Monooxygenase, DBH-Like 2, Pseudogene

(Previous names: monooxygenase, DBH-like 2 pseudogene)
(Previous symbol: MOXD2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Monooxygenase, DBH-Like 2, Pseudogene1 2
MOXD21 2 3
Monooxygenase, DBH-Like 2 Pseudogene1
EC 1.14.17.-3
DBH-Like Monooxygenase Protein 2 Pseudogene3

External Ids:    HGNC: 336051   Entrez Gene: 1002890172   Ensembl: ENSG000002402687   UniProtKB: A6NHM93   

Export aliases for MOXD2P gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MOXD2P Gene:
MOXD2P (monooxygenase, DBH-like 2, pseudogene) is a pseudogene. GO annotations related to this gene include dopamine beta-monooxygenase activity and copper ion binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  NT_187562.1  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MOXD2P
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MOXD2P

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MOXD2P


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

MOXD2P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOXD2P gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M141942:  view genomic region     (about GC identifiers)

Start:
141,940,556 bp from pter      End:
141,946,886 bp from pter
Size:
6,331 bases      Orientation:
minus strand

2 alternative locations:
Chr7-,CRA_TCAG 141,278,759-141,285,091      Chr7-,NW_003571040 382,707-389,037     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MOXD2_HUMAN, A6NHM9 (See protein sequence)
Recommended Name: Putative DBH-like monooxygenase protein 2 precursor  
Size: 499 amino acids; 56320 Da
Cofactor: Binds 2 copper ions per subunit (By similarity)
Caution: Could be the product of a pseudogene. The human MOXD2 gene lacks the last 2 terminal exons, as well as
the 3'-UTR and poly(A) signal found in all other mammalian sequences. This deletion, which occured after the
divergence of humans and chimpanzees, may interfere with proper mRNA processing and/or translation

Explore the universe of human proteins at neXtProt for MOXD2P: NX_A6NHM9

Post-translational modifications: 

  • Glycosylation2 at Asn236, Asn250, Asn404, Asn476

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR000945 DBH-rel
     IPR008977 PHM/PNGase_F_dom
     IPR000323 Cu2_ascorb_mOase_N
     IPR005018 DOMON_domain
     IPR028464 Moxd2

    Graphical View of Domain Structure for InterPro Entry A6NHM9

    ProtoNet protein and cluster: A6NHM9

    UniProtKB/Swiss-Prot: MOXD2_HUMAN, A6NHM9
    Similarity: Belongs to the copper type II ascorbate-dependent monooxygenase family
    Similarity: Contains 1 DOMON domain


    Find genes that share domains with MOXD2P           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Number (IUBMB): EC 1.14.17.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507copper ion binding IEA--
    GO:0016715oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA--
         
    Find genes that share ontologies with MOXD2P           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Interactions:

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MOXD2P (MOXD2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
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    Unigene Cluster for MOXD2P:

    Monooxygenase, DBH-like 2, pseudogene
    Hs.641504  [show with all ESTs]
    Unigene Representative Sequence: NR_024346
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460233(uc022amw.1) ENST00000477615
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    Additional mRNA sequence: NR_024346.2 

    1 DOTS entry:

    DT.121042838 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MOXD2P expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MOXD2P Expression
    About this image

    MOXD2P Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.641504
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MOXD2P gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Moxd25 monooxygenase, DBH-like 2   --   6 (18.92 cM) 40878794 


    ENSEMBL Gene Tree for MOXD2P (if available)
    TreeFam Gene Tree for MOXD2P (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MOXD2P gene
    2 SIMAP similar genes for MOXD2P using alignment to 1 protein entry:     MOXD2_HUMAN:
    MOXD1    DBH

    Find genes that share paralogs with MOXD2P           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MOXD2P (see all 257)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895435931,2
    --141940066(+) CCCACC/TGCCTG 1 -- ds50010--------
    rs15736171,2
    C,F,O,A,H--141940073(+) CCTGTG/AGGAAT 1 -- ds500126Minor allele frequency- A:0.38EA MN NS NA WA CSA 2713
    rs1826144371,2
    --141940262(+) GGGGAC/GAGTGT 1 -- ds50010--------
    rs1853406501,2
    --141940281(+) GGAGAA/GAATGG 1 -- ds50010--------
    rs1113558861,2
    C--141940302(+) GCTTGT/-TAGGC 1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs1475143971,2
    C--141940346(+) CATGTC/TTCATT 1 -- ds50010--------
    rs1900480711,2
    --141940480(+) TGGGTA/GGGGCT 1 -- ds50010--------
    rs1401204241,2
    --141940502(+) TCCCCC/GAGTCC 1 -- ds50010--------
    rs47265011,2
    C,F,A,H--141940557(+) TGACTC/TACTCT 1 -- nc-transcript-variant25Minor allele frequency- T:0.20NS EA NA WA CSA 2772
    rs1829831191,2
    C--141940567(+) TGATGC/TCTCCT 1 -- nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for MOXD2P (141940556 - 141946886 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MOXD2P:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33962CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MOXD2P gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with MOXD2P)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inactivation of MOXD2 and S100A15A by exon deletion during human evolution. (PubMed id 17642472)1, 2 Hahn Y.... Lee B. (Mol. Biol. Evol. 2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    4. An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells. (PubMed id 19056690)1 Van de Walle I....Taghon T. (Blood 2009)
    5. Autoreactive T-cell receptor (Vbeta/D/Jbeta) sequences in diabetes are homologous to insulin, glucagon, the insulin receptor, and the glucagon receptor. (PubMed id 19051206)1 Root-Bernstein R. (J. Mol. Recognit. 2009)
    6. Assembled DJ beta complexes influence TCR beta chain selection and peripheral V beta repertoire. (PubMed id 19380806)1 Carpenter A.C....Bassing C.H. (J. Immunol. 2009)
    7. Different allelic distribution of a single SNP between sexes in humans. (PubMed id 18777093)1 Tripputi P....Fedele L. (Biochem. Genet. 2008)
    8. CD4+ T cells target epitopes residing within the RNA-binding domain of the U1-70-kDa small nuclear ribonucleoprotein autoantigen and have restricted TCR diversity in an HLA-DR4-transgenic murine model of mixed connective tissue disease. (PubMed id 18523312)1 Greidinger E.L....Hoffman R.W. (J. Immunol. 2008)
    9. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PubMed id 8650574)1 Rowen L.... Hood L. (Science 1996)
    10. Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genes. (PubMed id 2144610)1 Gottschalk L.R. and Leiden J.M. (Mol. Cell. Biol. 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100289017 HGNC: 33605 Ensembl:ENSG00000240268 euGenes: HUgn100289017 ECgene: MOXD2P
    H-InvDB: MOXD2P

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MOXD2P gene:
    Search GeneIP for patents involving MOXD2P

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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