MOXD2P Gene
pseudogene GIFtS: 26
GCID: GC07M141942
|
|
monooxygenase, DBH-like 2, pseudogene(Previous names: monooxygenase, DBH-like 2 pseudogene )
(Previous symbol: MOXD2)
| |
Aliases
for MOXD2P gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Monooxygenase, DBH-Like 2, Pseudogene1 2 | | MOXD21 2 3 | | Monooxygenase, DBH-Like 2 Pseudogene1 | | EC 1.14.17.-3 | | DBH-Like Monooxygenase Protein 2 Pseudogene3 |
| External Ids: | HGNC: 336051 | Entrez Gene: 1002890172 | Ensembl: ENSG000002402687 | UniProtKB: A6NHM93 | | ORGUL members: | |
|---|
| NONCODE:n369506 | |
Export aliases for MOXD2P gene to outside databases
|---|
Summaries
for MOXD2P gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MOXD2P gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MOXD2P
Other transcription factors
Search SABiosciences Chromatin IP Primers for MOXD2P
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOXD2P |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34MOXD2P Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M141942: view genomic region
(about GC identifiers)
Start:
|
141,940,556 bp from pter |
End:
|
141,946,886 bp from pter |
Size:
|
6,331 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 141,278,759-141,285,091 |
|
Proteins
for MOXD2P gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MOXD2_HUMAN, A6NHM9 (See
protein sequence)Recommended Name: Putative DBH-like monooxygenase protein 2 precursor Size: 499 amino acids; 56320 Da
Cofactor: Binds 2 copper ions per subunit (By similarity)
Caution: Could be the product of a pseudogene. The human MOXD2 gene lacks the last 2 terminal exons, as well as the3'-UTR and poly(A) signal found in all other mammalian sequences. This deletion, which occured after the divergence ofhumans and chimpanzees, may interfere with proper mRNA processing and/or translationExplore the universe of human proteins at neXtProt for MOXD2P: NX_A6NHM9
MOXD2P Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products for MOXD2P:
MOXD2P Antibody Products:
Assay Products for MOXD2P: |
Protein
Domains /
Families
for MOXD2P gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MOXD2P for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NHM9ProtoNet protein and cluster: A6NHM9 UniProtKB/Swiss-Prot: MOXD2_HUMAN, A6NHM9Similarity: Belongs to the copper type II ascorbate-dependent monooxygenase familySimilarity: Contains 1 DOMON domain |
Function
for MOXD2P gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 1.14.17.-1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004500 | dopamine beta-monooxygenase activity |
IEA | -- | | GO:0005507 | copper ion binding |
IEA | -- |
MOXD2P for ontologies About GeneDecksing
Animal Models:
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOXD2P |
|
Pathways & Interactions
for MOXD2P gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOXD2P
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006584 | catecholamine metabolic process |
IEA | -- |
MOXD2P for ontologies About GeneDecksing
|
Drugs & Compounds
for MOXD2P gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MOXD2P
Search CenterWatch for drugs/clinical trials and news about MOXD2P 
|
Transcripts
for MOXD2P gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for MOXD2P: Monooxygenase, DBH-like 2, pseudogene Hs.641504 [show with all ESTs]Unigene Representative Sequence: NR_0243463 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000460233(uc022amw.1) ENST00000477615 ENST00000466789
Additional cDNA sequence: NR_024346.2 1 DOTS entry: DT.121042838
GeneLoc Exon Structure
|
Expression
for MOXD2P gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MOXD2P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.641504
SABiosciences Custom PCR Arrays for MOXD2P
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MOXD2P | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOXD2P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOXD2P | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOXD2P |
Orthologs
for MOXD2P gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for MOXD2P gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Moxd25 |
monooxygenase, DBH-like 2 |
-- |
|
6 (18.92 cM) 40878794 |
ENSEMBL Gene Tree for MOXD2P (if available)
TreeFam Gene Tree for MOXD2P (if available) |
Paralogs
for MOXD2P gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MOXD2P gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MOXD2P (141940556 - 141946886 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MOXD2P: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MOXD2P gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MOXD2P for disorders About GeneDecksing
3  diseases for MOXD2P: About MalaCardsmixed connective tissue disease connective tissue disease pancreatitis
Export disorders for MOXD2P gene to outside databases
|
Publications
for MOXD2P gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MOXD2P gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with MOXD2P) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Inactivation of MOXD2 and S100A15A by exon deletion during human evolution. (PubMed id 17642472)1, 2 Hahn Y.... Lee B. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells. (PubMed id 19056690)1 Van de Walle I....Taghon T. (2009)
- Autoreactive T-cell receptor (Vbeta/D/Jbeta) sequences in diabetes are homologous to insulin, glucagon, the insulin receptor, and the glucagon receptor. (PubMed id 19051206)1 Root-Bernstein R. (2009)
- Assembled DJ beta complexes influence TCR beta chain selection and peripheral V beta repertoire. (PubMed id 19380806)1 Carpenter A.C....Bassing C.H. (2009)
- Different allelic distribution of a single SNP between sexes in humans. (PubMed id 18777093)1 Tripputi P....Fedele L. (2008)
- CD4+ T cells target epitopes residing within the RNA-binding domain of the U1-70-kDa small nuclear ribonucleoprotein autoantigen and have restricted TCR diversity in an HLA-DR4-transgenic murine model of mixed connective tissue disease. (PubMed id 18523312)1 Greidinger E.L....Hoffman R.W. (2008)
- The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. (PubMed id 8650574)1 Rowen L.... Hood L. (1996)
- Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genes. (PubMed id 2144610)1 Gottschalk L.R. and Leiden J.M. (1990)
|
External Searches for MOXD2P gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MOXD2P gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MOXD2P gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MOXD2P gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MOXD2P gene:
Search GeneIP for patents involving MOXD2P
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MOXD2P gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MOXD2P | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MOXD2P | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOXD2P | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOXD2P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOXD2P | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOXD2P |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MOXD2P |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOXD2P |
|  |  |  |  | | | | Search ThermoFisher Antibodies for MOXD2P |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MOXD2P |
| |  | |
|
|
|
GeneCards Homepage -
Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013
View Random Gene
|
Category
|
|
|
von Willebrand factor
|
| GIFtS Group |
|
Developed at the Crown Human Genome Center,
Department of Molecular Genetics,
the Weizmann Institute of Science
Copyright © 1996-2013
, Weizmann Institute of Science. All Rights Reserved.
hostname: 356977-web1.xennexinc.com
index build: 106 solr: 1.4
|
