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Aliases for MOXD1 Gene

Aliases for MOXD1 Gene

  • Monooxygenase DBH Like 1 2 3
  • Monooxygenase, DBH-Like 1 2 3 5
  • Monooxygenase X 3 4
  • MOX 3 4
  • Dopamine-Oxygenase 3
  • EC 1.14.17.- 4
  • EC 1.14.17 63
  • DJ248E1.1 3
  • PRO5780 3

External Ids for MOXD1 Gene

Previous GeneCards Identifiers for MOXD1 Gene

  • GC06M132553
  • GC06M132597
  • GC06M132658
  • GC06M130192

Summaries for MOXD1 Gene

GeneCards Summary for MOXD1 Gene

MOXD1 (Monooxygenase DBH Like 1) is a Protein Coding gene. Diseases associated with MOXD1 include mesenteric lymphadenitis. GO annotations related to this gene include copper ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen. An important paralog of this gene is DBH.

Gene Wiki entry for MOXD1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOXD1 Gene

Genomics for MOXD1 Gene

Regulatory Elements for MOXD1 Gene

Promoters for MOXD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MOXD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MOXD1 Gene

Chromosome:
6
Start:
132,296,055 bp from pter
End:
132,401,545 bp from pter
Size:
105,491 bases
Orientation:
Minus strand

Genomic View for MOXD1 Gene

Genes around MOXD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOXD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOXD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOXD1 Gene

Proteins for MOXD1 Gene

  • Protein details for MOXD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UVY6-MOXD1_HUMAN
    Recommended name:
    DBH-like monooxygenase protein 1
    Protein Accession:
    Q6UVY6
    Secondary Accessions:
    • Q5THU6
    • Q8NC97
    • Q8WV49
    • Q9H4M6
    • Q9Y4U3

    Protein attributes for MOXD1 Gene

    Size:
    613 amino acids
    Molecular mass:
    69652 Da
    Cofactor:
    Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11263.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MOXD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOXD1 Gene

Proteomics data for MOXD1 Gene at MOPED

Selected DME Specific Peptides for MOXD1 Gene

Post-translational modifications for MOXD1 Gene

Other Protein References for MOXD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MOXD1 Gene

Suggested Antigen Peptide Sequences for MOXD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UVY6

UniProtKB/Swiss-Prot:

MOXD1_HUMAN :
  • Contains 1 DOMON domain.
  • Belongs to the copper type II ascorbate-dependent monooxygenase family.
Domain:
  • Contains 1 DOMON domain.
Family:
  • Belongs to the copper type II ascorbate-dependent monooxygenase family.
genes like me logo Genes that share domains with MOXD1: view

No data available for Gene Families for MOXD1 Gene

Function for MOXD1 Gene

Molecular function for MOXD1 Gene

UniProtKB/Swiss-Prot Induction:
By replicative senescence.

Enzyme Numbers (IUBMB) for MOXD1 Gene

Gene Ontology (GO) - Molecular Function for MOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MOXD1: view

Phenotypes for MOXD1 Gene

genes like me logo Genes that share phenotypes with MOXD1: view

Animal Models for MOXD1 Gene

MGI Knock Outs for MOXD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for MOXD1

miRNA for MOXD1 Gene

miRTarBase miRNAs that target MOXD1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOXD1 Gene

Localization for MOXD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOXD1 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOXD1 Gene COMPARTMENTS Subcellular localization image for MOXD1 gene
Compartment Confidence
endoplasmic reticulum 4
peroxisome 3
extracellular 2
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MOXD1: view

Pathways & Interactions for MOXD1 Gene

SuperPathways for MOXD1 Gene

No Data Available

Interacting Proteins for MOXD1 Gene

Gene Ontology (GO) - Biological Process for MOXD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MOXD1 Gene

Drugs & Compounds for MOXD1 Gene

(2) Drugs for MOXD1 Gene - From: HMDB and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nepicastat (SYN-117) HCl Pharma Dopamine-β-hydroxylase inhibitor 0
Copper Pharma 158
genes like me logo Genes that share compounds with MOXD1: view

Transcripts for MOXD1 Gene

Unigene Clusters for MOXD1 Gene

Monooxygenase, DBH-like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOXD1 Gene

No ASD Table

Relevant External Links for MOXD1 Gene

GeneLoc Exon Structure for
MOXD1
ECgene alternative splicing isoforms for
MOXD1

Expression for MOXD1 Gene

mRNA expression in normal human tissues for MOXD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOXD1 Gene

This gene is overexpressed in Uterus (x4.7).

Protein differential expression in normal tissues from HIPED for MOXD1 Gene

This gene is overexpressed in Uterus (16.0), Fetal gut (7.8), and Prostate (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MOXD1 Gene



SOURCE GeneReport for Unigene cluster for MOXD1 Gene Hs.6909

mRNA Expression by UniProt/SwissProt for MOXD1 Gene

Q6UVY6-MOXD1_HUMAN
Tissue specificity: Highly expressed in lung, kidney, brain and spinal cord.
genes like me logo Genes that share expression patterns with MOXD1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for MOXD1 Gene

Orthologs for MOXD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MOXD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOXD1 36
  • 100 (a)
OneToOne
MOXD1 35
  • 99.46 (n)
  • 99.51 (a)
cow
(Bos Taurus)
Mammalia MOXD1 35
  • 89.06 (n)
  • 89.78 (a)
MOXD1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOXD1 36
  • 89 (a)
OneToOne
MOXD1 35
  • 89.46 (n)
  • 89.97 (a)
mouse
(Mus musculus)
Mammalia Moxd1 16
Moxd1 36
  • 85 (a)
OneToOne
Moxd1 35
  • 84.14 (n)
  • 86.21 (a)
oppossum
(Monodelphis domestica)
Mammalia MOXD1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Moxd1 35
  • 84.02 (n)
  • 86.55 (a)
chicken
(Gallus gallus)
Aves LOC777223 35
  • 76.97 (n)
  • 82.53 (a)
-- 36
  • 78 (a)
OneToMany
MOXD1 36
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MOXD1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia moxd1 35
  • 68.36 (n)
  • 66.2 (a)
zebrafish
(Danio rerio)
Actinopterygii moxd1 35
  • 62.39 (n)
  • 62.39 (a)
moxd1 36
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011613 35
  • 48.01 (n)
  • 42.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta olf413 35
  • 45.37 (n)
  • 35.9 (a)
CG5235 36
  • 26 (a)
OneToMany
olf413 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for MOXD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOXD1 Gene

ENSEMBL:
Gene Tree for MOXD1 (if available)
TreeFam:
Gene Tree for MOXD1 (if available)

Paralogs for MOXD1 Gene

Paralogs for MOXD1 Gene

(2) SIMAP similar genes for MOXD1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MOXD1: view

Variants for MOXD1 Gene

Sequence variations from dbSNP and Humsavar for MOXD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs36075540 - 132,315,681(-) TTATG(C/G)AACAA reference, missense
rs17851680 - 132,297,849(+) CAGCT(C/T)GTTGA reference, missense
rs15017 -- 132,296,235(+) AGAAC(C/G)ATGAC utr-variant-3-prime
rs628227 -- 132,318,778(-) aaacc(A/G)ctgga intron-variant
rs672312 -- 132,314,236(-) TGATC(A/C)ATGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOXD1 Gene

Variant ID Type Subtype PubMed ID
nsv886674 CNV Loss 21882294
nsv830811 CNV Gain 17160897
nsv886675 CNV Loss 21882294
nsv818455 CNV Loss 17921354
esv2672404 CNV Deletion 23128226
esv2257358 CNV Deletion 18987734
esv2791 CNV Deletion 18987735
esv2732715 CNV Deletion 23290073
esv1005349 CNV Deletion 20482838
esv5479 CNV Loss 19470904
esv1048627 CNV Deletion 17803354
nsv5480 CNV Loss 18451855
esv2732716 CNV Deletion 23290073
esv2669946 CNV Deletion 23128226
esv2674189 CNV Deletion 23128226
nsv499756 CNV Loss 21111241
esv23627 CNV Loss 19812545
esv9597 CNV Gain 19470904
esv2422115 CNV Deletion 20811451
nsv442008 CNV CNV 18776908
nsv514389 CNV Loss 21397061

Variation tolerance for MOXD1 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOXD1 Gene

HapMap Linkage Disequilibrium report
MOXD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOXD1 Gene

Disorders for MOXD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MOXD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mesenteric lymphadenitis
  • mesenteric adenitis
- elite association - COSMIC cancer census association via MalaCards
Search MOXD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MOXD1

Genetic Association Database (GAD)
MOXD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOXD1
genes like me logo Genes that share disorders with MOXD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOXD1 Gene

Publications for MOXD1 Gene

  1. Identification and cloning of a sequence homologue of dopamine beta- hydroxylase. (PMID: 9751809) Chambers K.J. … Funk W.D. (Gene 1998) 2 3 4 67
  2. Monooxygenase X, a member of the copper-dependent monooxygenase family localized to the endoplasmic reticulum. (PMID: 15337741) Xin X. … Eipper B.A. (J. Biol. Chem. 2004) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 3

Products for MOXD1 Gene

Sources for MOXD1 Gene

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