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Aliases for MOXD1 Gene

Aliases for MOXD1 Gene

  • Monooxygenase, DBH-Like 1 2 3
  • MOX 3 4 6
  • Monooxygenase X 3 4
  • DBH-Like Monooxygenase Protein 1 3
  • Dopamine-Oxygenase 3
  • EC 1.14.17.- 4
  • EC 1.14.17 64
  • DJ248E1.1 3
  • PRO5780 3

External Ids for MOXD1 Gene

Summaries for MOXD1 Gene

GeneCards Summary for MOXD1 Gene

MOXD1 (Monooxygenase, DBH-Like 1) is a Protein Coding gene. GO annotations related to this gene include copper ion binding and dopamine beta-monooxygenase activity. An important paralog of this gene is DBH.

Gene Wiki entry for MOXD1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOXD1 Gene

Genomics for MOXD1 Gene

Genomic Location for MOXD1 Gene

Start:
132,296,055 bp from pter
End:
132,401,545 bp from pter
Size:
105,491 bases
Orientation:
Minus strand

Genomic View for MOXD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MOXD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOXD1 Gene

Regulatory Elements for MOXD1 Gene

Proteins for MOXD1 Gene

  • Protein details for MOXD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UVY6-MOXD1_HUMAN
    Recommended name:
    DBH-like monooxygenase protein 1
    Protein Accession:
    Q6UVY6
    Secondary Accessions:
    • Q5THU6
    • Q8NC97
    • Q8WV49
    • Q9H4M6
    • Q9Y4U3

    Protein attributes for MOXD1 Gene

    Size:
    613 amino acids
    Molecular mass:
    69652 Da
    Cofactor:
    Name=Cu(2+); Xref=ChEBI:CHEBI:29036; Note=Binds 2 copper ions per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11263.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MOXD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOXD1 Gene

Proteomics data for MOXD1 Gene at MOPED

Selected DME Specific Peptides for MOXD1 Gene

Post-translational modifications for MOXD1 Gene

Other Protein References for MOXD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for MOXD1 Gene

UniProtKB/Swiss-Prot:

MOXD1_HUMAN
Domain:
  • Contains 1 DOMON domain.:
    • Q6UVY6
Family:
  • Belongs to the copper type II ascorbate-dependent monooxygenase family.:
    • Q6UVY6
genes like me logo Genes that share domains with MOXD1: view

No data available for Gene Families for MOXD1 Gene

Function for MOXD1 Gene

Molecular function for MOXD1 Gene

UniProtKB/Swiss-Prot Induction: By replicative senescence.

Enzyme Numbers (IUBMB) for MOXD1 Gene

Gene Ontology (GO) - Molecular Function for MOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004497 monooxygenase activity --
GO:0005507 copper ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA --
genes like me logo Genes that share ontologies with MOXD1: view

Phenotypes for MOXD1 Gene

GenomeRNAi human phenotypes for MOXD1:
genes like me logo Genes that share phenotypes with MOXD1: view

miRNA for MOXD1 Gene

miRTarBase miRNAs that target MOXD1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MOXD1 Gene

Localization for MOXD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOXD1 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOXD1 Gene COMPARTMENTS Subcellular localization image for MOXD1 gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 2
cytosol 1
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IDA 15337741
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MOXD1: view

Pathways for MOXD1 Gene

SuperPathways for MOXD1 Gene

No Data Available

Interacting Proteins for MOXD1 Gene

Gene Ontology (GO) - Biological Process for MOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MOXD1: view

No data available for Pathways by source for MOXD1 Gene

Compounds for MOXD1 Gene

(1) HMDB Compounds for MOXD1 Gene

Compound Synonyms Cas Number PubMed IDs
Copper
  • Cu
7440-50-8
genes like me logo Genes that share compounds with MOXD1: view

Transcripts for MOXD1 Gene

mRNA/cDNA for MOXD1 Gene

Unigene Clusters for MOXD1 Gene

Monooxygenase, DBH-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOXD1 Gene

No ASD Table

Relevant External Links for MOXD1 Gene

GeneLoc Exon Structure for
MOXD1
ECgene alternative splicing isoforms for
MOXD1

Expression for MOXD1 Gene

mRNA expression in normal human tissues for MOXD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOXD1 Gene

This gene is overexpressed in Uterus (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MOXD1 Gene

SOURCE GeneReport for Unigene cluster for MOXD1 Gene Hs.6909

mRNA Expression by UniProt/SwissProt for MOXD1 Gene

Q6UVY6-MOXD1_HUMAN
Tissue specificity: Highly expressed in lung, kidney, brain and spinal cord.
genes like me logo Genes that share expressions with MOXD1: view

Orthologs for MOXD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MOXD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOXD1 36
  • 99.46 (n)
  • 99.51 (a)
MOXD1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MOXD1 36
  • 89.06 (n)
  • 89.78 (a)
MOXD1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOXD1 36
  • 89.46 (n)
  • 89.97 (a)
MOXD1 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Moxd1 36
  • 84.14 (n)
  • 86.21 (a)
Moxd1 16
Moxd1 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MOXD1 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 86 (a)
OneToMany
-- 37
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Moxd1 36
  • 84.02 (n)
  • 86.55 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 78 (a)
OneToMany
LOC777223 36
  • 76.97 (n)
  • 82.53 (a)
MOXD1 37
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MOXD1 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia moxd1 36
  • 68.36 (n)
  • 66.2 (a)
zebrafish
(Danio rerio)
Actinopterygii moxd1 36
  • 62.39 (n)
  • 62.39 (a)
moxd1 37
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011613 36
  • 48.01 (n)
  • 42.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5235 37
  • 26 (a)
OneToMany
olf413 36
  • 45.37 (n)
  • 35.9 (a)
olf413 37
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToMany
Species with no ortholog for MOXD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOXD1 Gene

ENSEMBL:
Gene Tree for MOXD1 (if available)
TreeFam:
Gene Tree for MOXD1 (if available)

Paralogs for MOXD1 Gene

Paralogs for MOXD1 Gene

Selected SIMAP similar genes for MOXD1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MOXD1: view

Variants for MOXD1 Gene

Sequence variations from dbSNP and Humsavar for MOXD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs15017 -- 132,296,235(+) AGAAC(C/G)ATGAC utr-variant-3-prime
rs584864 -- 132,304,258(-) ttcca(A/G)gatgg intron-variant
rs589756 -- 132,321,978(+) AAAAC(A/C)CTGTC intron-variant
rs591109 -- 132,322,306(+) TATCT(C/T)TTCAA intron-variant
rs598597 -- 132,306,963(-) gattt(C/T)gcaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOXD1 Gene

Variant ID Type Subtype PubMed ID
nsv886674 CNV Loss 21882294
nsv830811 CNV Gain 17160897
nsv886675 CNV Loss 21882294
nsv818455 CNV Loss 17921354
esv2672404 CNV Deletion 23128226
esv2257358 CNV Deletion 18987734
esv2791 CNV Deletion 18987735
esv2732715 CNV Deletion 23290073
esv1005349 CNV Deletion 20482838
esv5479 CNV Loss 19470904
esv1048627 CNV Deletion 17803354
nsv5480 CNV Loss 18451855
esv2732716 CNV Deletion 23290073
esv2669946 CNV Deletion 23128226
esv2674189 CNV Deletion 23128226
nsv499756 CNV Loss 21111241
esv23627 CNV Loss 19812545
esv9597 CNV Gain 19470904
esv2422115 CNV Deletion 20811451
nsv442008 CNV CNV 18776908
nsv514389 CNV Loss 21397061

Relevant External Links for MOXD1 Gene

HapMap Linkage Disequilibrium report
MOXD1

Disorders for MOXD1 Gene

Relevant External Links for MOXD1

Genetic Association Database (GAD)
MOXD1
genes like me logo Genes that share disorders with MOXD1: view

No data available for UniProtKB/Swiss-Prot for MOXD1 Gene

Publications for MOXD1 Gene

  1. Monooxygenase X, a member of the copper-dependent monooxygenase family localized to the endoplasmic reticulum. (PMID: 15337741) Xin X. … Eipper B.A. (J. Biol. Chem. 2004) 3 4 23
  2. Identification and cloning of a sequence homologue of dopamine beta- hydroxylase. (PMID: 9751809) Chambers K.J. … Funk W.D. (Gene 1998) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells. (PMID: 20581860) Paggetti J. … Delva L. (Oncogene 2010) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for MOXD1 Gene

Sources for MOXD1 Gene

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