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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MOXD1 Gene

protein-coding   GIFtS: 53
GCID: GC06M132658

monooxygenase, DBH-like 1

 Explore 4 diseases affiliated with
MOXD1 via our new
 Human Malady Compendium 
Biological research products
for MOXD1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Monooxygenase, DBH-Like 11 2     PRO57802
MOX1 2 3 5     DBH-Like Monooxygenase Protein 12
DJ248E1.11     Dopamine-Oxygenase1
Monooxygenase X2 3     EC 1.14.17.-3
DKFZP564G2021     EC 1.14.178

External Ids:    HGNC: 210631   Entrez Gene: 260022   Ensembl: ENSG000000799317   OMIM: 6090005   UniProtKB: Q6UVY63   

Export aliases for MOXD1 gene to outside databases

Previous GC identifers: GC06M132553 GC06M132597 GC06M130192


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for MOXD1 (Monooxygenase DBH-like 1)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MOXD1 gene promoter:
         Max1   STAT1   LCR-F1   E4BP4   FOXJ2 (long isoform)   FOXO4   FOXJ2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOXD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MOXD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOXD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23.2   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23.2

MOXD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOXD1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M132658:  view genomic region     (about GC identifiers)

Start:
132,617,194 bp from pter      End:
132,722,684 bp from pter
Size:
105,491 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MOXD1_HUMAN, Q6UVY6 (See protein sequence)
Recommended Name: DBH-like monooxygenase protein 1 precursor  
Size: 613 amino acids; 69652 Da
Cofactor: Binds 2 copper ions per subunit (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity)
Developmental stage: Expressed in fetal liver and fetal brain
Sequence caution: Sequence=BAC11263.1; Type=Erroneous initiation;
Secondary accessions: Q5THU6 Q8NC97 Q8WV49 Q9H4M6 Q9Y4U3
Alternative splicing: 2 isoforms:  Q6UVY6-1   Q6UVY6-2   (Major)

Explore the universe of human proteins at neXtProt for MOXD1: NX_Q6UVY6

Post-translational modifications:

  • N-glycosylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6UVY6

  • 2 DME Specific Peptides for MOXD1 (Q6UVY6)
     STVRVIWA  MTWGGLSTR 

    MOXD1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056344.2  
    ENSEMBL proteins: 
     ENSP00000356940   ENSP00000336998   ENSP00000376202  

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    Uscn Proteins for MOXD1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--


    MOXD1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MOXD1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000945 Dopamine_b_mOase
     IPR008977 PHM/PNGase_F_dom
     IPR000323 Cu2_ascorb_mOase_N
     IPR005018 DOMON_domain
     IPR014784 Cu2_ascorb_mOase-like_C

    Graphical View of Domain Structure for InterPro Entry Q6UVY6

    ProtoNet protein and cluster: Q6UVY6

    2 Blocks protein families:
    IPB000323 Copper type II
    IPB000945 Dopamine-beta-monooxygenase signature


    UniProtKB/Swiss-Prot: MOXD1_HUMAN, Q6UVY6
    Similarity: Belongs to the copper type II ascorbate-dependent monooxygenase family
    Similarity: Contains 1 DOMON domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MOXD1_HUMAN, Q6UVY6
    Induction: By replicative senescence

    Enzyme Numbers (IUBMB): EC 1.14.172 EC 1.14.17.-1

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    SwitchGear 3'UTR luciferase reporter plasmidMOXD1 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOXD1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004500dopamine beta-monooxygenase activity IEA--
    GO:0005507copper ion binding IEA--


    MOXD1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MOXD1:
     Increased G2M DNA content 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOXD1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for MOXD1 (Q6UVY62, 3 ENSP000003569404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253429 I2D: score=2 
    TIMM50Q3ZCQ83I2D: score=5 
    WDR5ENSP000003514464STRING: ENSP00000351446
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006584catecholamine metabolic process IEA--


    MOXD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MOXD1

    1 HMDB Compound for MOXD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--
    Search CenterWatch for drugs/clinical trials and news about MOXD1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MOXD1 gene: 
    NM_015529.2  

    Unigene Cluster for MOXD1:

    Monooxygenase, DBH-like 1
    Hs.6909  [show with all ESTs]
    Unigene Representative Sequence: NM_015529
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367963(uc003qdf.3) ENST00000336749(uc003qde.3) ENST00000489128
    ENST00000392401

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    hsa-miR-3163 hsa-miR-640 hsa-miR-1283 hsa-miR-4279 hsa-miR-575 hsa-miR-548c-3p
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    Inhib. RNA
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    Additional cDNA sequence: 

    AJ420565.1 AK074879.1 AK226054.1 AL080058.1 AY007239.1 AY359094.1 BC018756.1 

    6 DOTS entries:

    DT.214619  DT.100744159  DT.100744160  DT.92423180  DT.91726459  DT.75174276 

    24/123 AceView cDNA sequences (see all 123):

    AI799773 AA235998 BQ893468 C01809 AA905700 AW665738 BE835367 AY359094 
    BE502131 BE835338 AW338818 AI379441 AI520849 AI567721 BQ894238 AI086817 
    AA618502 N38779 AW236423 AA604597 AW316784 AL524132 BU543008 AA907610 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MOXD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCAATAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    MOXD1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerCholinergic Amacrine CellsAmacrine, Retina
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)

    See MOXD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MOXD1

    SOURCE GeneReport for Unigene cluster: Hs.6909

    UniProtKB/Swiss-Prot: MOXD1_HUMAN, Q6UVY6
    Tissue specificity: Highly expressed in lung, kidney, brain and spinal cord

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MOXD1 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC7772231 DBH-like monooxygenase protein 1-like 75.48(n)
    80.89(a)
      777223  XM_003641028.1  XP_003641076.1 
    lizard
    (Anolis carolinensis)
    Reptilia MOXD16
    --
    74(a)
    1 ↔ 1
    GL343200.1(4570326-4621309)
    zebrafish
    (Danio rerio)
    Actinopterygii moxd11 monooxygenase, DBH-like 1 61.82(n)
    61.59(a)
      570584  NM_001045206.2  NP_001038671.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta olf4131 CG12673-PB 45.09(n)
    35.48(a)
      40453  NM_168948.4  NP_730711.3 


    ENSEMBL Gene Tree for MOXD1 (if available)
    TreeFam Gene Tree for MOXD1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MOXD1 gene
    PAM2  DBH2  
    2 SIMAP similar genes for MOXD1 using alignment to 2 protein entries:     MOXD1_HUMAN (see all proteins):
    MOXD2P    DBH

    MOXD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2000 NCBI SNPs in MOXD1 are shown (see all 2000    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1818367511,2
    --132616908(+) AATCAC/TAGAAT 1 -- ds50010--------
    rs737790201,2
    C,F,--132616945(+) GAAAGT/CAAACT 1 -- ds50013Minor allele frequency- C:0.21WA CSA 122
    rs1440265641,2
    --132617040(+) TTATTC/TAAAAG 1 -- ds50010--------
    rs69028751,2
    C,F,A,H,--132617072(+) ACATTG/ATGGGG 1 -- ds500125Minor allele frequency- A:0.50NA NS EA WA CSA 2490
    rs69256881,2
    C,F,A,H,--132617135(+) ACTGTT/CAATAC 1 -- ds500125Minor allele frequency- C:0.48NA NS EA WA CSA 2487
    rs1509654321,2
    --132617165(+) TTTCTC/TAAACA 1 -- ds50010--------
    rs744767601,2
    --132617275(+) TTGGCA/TGAGCT 1 -- ut310--------
    rs780585771,2
    C,F,--132617298(+) CCAAAA/CGAGTG 1 -- ut311Minor allele frequency- C:0.11WA 118
    rs1501514701,2
    --132617301(+) AAAGAA/GTGACA 1 -- ut310--------
    rs1123070611,2
    C,--132617364(+) AATCTG/ACAATA 1 -- ut312Minor allele frequency- A:0.33WA CSA 3

    HapMap Linkage Disequilibrium report for MOXD1 (132617194 - 132722684 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for MOXD1
         5 CNVs: 10166 36458 64661 37447 38625
         5 Indels: 28095 60621 46998 42860 62573

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MOXD1 for disorders           About GeneDecksing

    OMIM gene information: 609000    OMIM disorders: --

    4 diseases for MOXD1:    About MalaCards
    mesenteric lymphadenitis    lymphadenitis    ocular hypotension    leukemia


    Export disorders for MOXD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MOXD1 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with MOXD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and cloning of a sequence homologue of dopamine beta- hydroxylase. (PubMed id 9751809)1, 2, 3 Chambers K.J....Funk W.D. (1998)
    2. Monooxygenase X, a member of the copper-dependent monooxygenase family localized to the endoplasmic reticulum. (PubMed id 15337741)1, 2, 9 Xin X.... Eipper B.A. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    6. Crosstalk between leukemia-associated proteins MOZ an d MLL regulates HOX gene expression in human cord blood CD34+ cells. (PubMed id 20581860)1 Paggetti J....Delva L. (2010)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26002 HGNC: 21063 AceView: MOXD1 Ensembl:ENSG00000079931 euGenes: HUgn26002
    ECgene: MOXD1 H-InvDB: MOXD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MOXD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MOXD1 gene:
    Search GeneIP for patents involving MOXD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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