MOXD1 Gene
protein-coding GIFtS : 53
GCID: GC06 M132658
monooxygenase, DBH-like 1
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Aliasesfor MOXD1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Monooxygenase, DBH-Like 1 1 2 PRO57802 MOX1 2 3 5 DBH-Like Monooxygenase Protein 12 DJ248E1.11 Dopamine-Oxygenase1 Monooxygenase X2 3 EC 1.14.17.-3 DKFZP564G2021 EC 1.14.178
Export aliases for MOXD1 gene to outside databases Previous GC identifers: GC06M132553 GC06M132597 GC06M130192
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Summariesfor MOXD1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for MOXD1 (Monooxygenase DBH-like 1)
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Genomic Viewsfor MOXD1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_025741.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MOXD1 gene promoter: Max1 STAT1 LCR-F1 E4BP4 FOXJ2 (long isoform) FOXO4 FOXJ2 c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for MOXD1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOXD1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6q23.2 Ensembl cytogenetic band: 6q23.2 HGNC cytogenetic band: 6q23.2 MOXD1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06M132658: view genomic region
(about GC identifiers )
Start:
132,617,194 bp from pter
End:
132,722,684 bp from pter
Size:
105,491 bases
Orientation:
minus strand
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Proteinsfor MOXD1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MOXD1_HUMAN, Q6UVY6 (See
protein sequence )Recommended Name: DBH-like monooxygenase protein 1 precursor Size : 613 amino acids; 69652 Da
Cofactor : Binds 2 copper ions per subunit (By similarity)
Subcellular location : Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity)
Developmental stage : Expressed in fetal liver and fetal brain
Sequence caution : Sequence=BAC11263.1; Type=Erroneous initiation;
Secondary accessions : Q5THU6 Q8NC97 Q8WV49 Q9H4M6 Q9Y4U3Alternative splicing : 2 isoforms : Q6UVY6-1 Q6UVY6-2 (Major)Explore the universe of human proteins at neXtProt for MOXD1: NX_Q6UVY6 Post-translational modifications:
N-glycosylated (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6UVY6 2 DME Specific Peptides for MOXD1 (Q6UVY6 ) MOXD1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_056344.2 ENSEMBL proteins: ENSP00000356940 ENSP00000336998 ENSP00000376202 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005789 endoplasmic reticulum membrane
IEA -- GO:0016021 integral to membrane
IEA --
MOXD1 for ontologies About GeneDecksing MOXD1 Antibody Products: Assay Products for MOXD1:
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Protein
Domains / Familiesfor MOXD1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MOXD1 for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q6UVY6 ProtoNet protein and cluster: Q6UVY6
2 Blocks protein families : IPB000323 Copper type II IPB000945 Dopamine-beta-monooxygenase signature UniProtKB/Swiss-Prot: MOXD1_HUMAN, Q6UVY6 Similarity : Belongs to the copper type II ascorbate-dependent monooxygenase familySimilarity : Contains 1 DOMON domain
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Functionfor MOXD1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MOXD1_HUMAN, Q6UVY6 Induction : By replicative senescenceEnzyme Numbers (IUBMB): EC 1.14.17 2 EC 1.14.17.- 1
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MOXD1 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MOXD1 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MOXD1 (NM_015529 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MOXD1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MOXD1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOXD1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004500 dopamine beta-monooxygenase activity
IEA -- GO:0005507 copper ion binding
IEA --
MOXD1 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for MOXD1 :
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Pathways & Interactionsfor MOXD1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOXD1 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)3 Interacting proteins for MOXD1 (Q6UVY6 2 , 3 ENSP00000356940 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006584 catecholamine metabolic process
IEA --
MOXD1 for ontologies About GeneDecksing
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Drugs & Compoundsfor MOXD1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MOXD1 1 HMDB Compound for MOXD1 About this table Search CenterWatch for drugs/clinical trials and news about MOXD1
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Transcriptsfor MOXD1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MOXD1 gene: NM_015529.2 Unigene Cluster for MOXD1:
Monooxygenase, DBH-like 1 Hs.6909 [show with all ESTs ] Unigene Representative Sequence: NM_015529 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000367963 (uc003qdf.3 ) ENST00000336749 (uc003qde.3 ) ENST00000489128 ENST00000392401 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MOXD1 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MOXD1 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MOXD1 (NM_015529 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MOXD1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MOXD1
Additional cDNA sequence: AJ420565.1 AK074879.1 AK226054.1 AL080058.1 AY007239.1 AY359094.1 BC018756.1
6 DOTS entries : DT.214619 DT.100744159
DT.100744160 DT.92423180 DT.91726459 DT.75174276 24/123 AceView cDNA sequences (see all 123 ):
AI799773 AA235998 BQ893468 C01809 AA905700 AW665738 BE835367 AY359094 BE502131 BE835338 AW338818 AI379441 AI520849 AI567721 BQ894238 AI086817 AA618502 N38779 AW236423 AA604597 AW316784 AL524132 BU543008 AA907610 GeneLoc Exon Structure
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Expression for MOXD1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MOXD1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTCAATAAAA
About this image MOXD1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See MOXD1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MOXD1 SOURCE GeneReport for Unigene cluster: Hs.6909 UniProtKB/Swiss-Prot: MOXD1_HUMAN, Q6UVY6 Tissue specificity : Highly expressed in lung, kidney, brain and spinal cord SABiosciences Custom PCR Arrays for MOXD1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MOXD1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MOXD1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MOXD1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MOXD1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOXD1
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Orthologsfor MOXD1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for MOXD1 gene from 4/17 species (see all 17 ) About this table
ENSEMBL Gene Tree for MOXD1 (if available)TreeFam Gene Tree for MOXD1 (if available)
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Paralogsfor MOXD1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MOXD1 gene PAM 2 DBH 2 2 SIMAP similar genes for MOXD1 using alignment to 2 protein entries: MOXD1_HUMAN (see all proteins ):MOXD2P DBH
MOXD1 for paralogs About GeneDecksing
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Genomic Variantsfor MOXD1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MOXD1 (132617194 - 132722684 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 10 variations for MOXD1 5 CNVs : 10166 36458 64661 37447 38625 5 Indels : 28095 60621 46998 42860 62573
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MOXD1
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Disorders
/ Diseasesfor MOXD1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MOXD1 for disorders About GeneDecksing
OMIM gene information: 609000
OMIM disorders : --4 diseases for MOXD1 : About MalaCards mesenteric lymphadenitis lymphadenitis ocular hypotension leukemia Export disorders for MOXD1 gene to outside databases
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Publicationsfor MOXD1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MOXD1 gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with MOXD1) Utopia : connect your pdf to the dynamic world of online information
Identification and cloning of a sequence homologue of dopamine beta- hydroxylase. (PubMed id 9751809) 1 , 2 , 3 Chambers K.J....Funk W.D. (1998) Monooxygenase X, a member of the copper-dependent monooxygenase family localized to the endoplasmic reticulum. (PubMed id 15337741) 1 , 2 , 9 Xin X.... Eipper B.A. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206) 1 Vinayagam A....Wanker E.E. (2011) Crosstalk between leukemia-associated proteins MOZ an d MLL regulates HOX gene expression in human cord blood CD34+ cells. (PubMed id 20581860) 1 Paggetti J....Delva L. (2010) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 2 Mungall A.J.... Beck S. (2003)
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External Searches for MOXD1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MOXD1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MOXD1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing MOXD1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MOXD1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MOXD1 gene: Search GeneIP for patents involving MOXD1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MOXD1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MOXD1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MOXD1 OriGene Protein Over-expression Lysate for MOXD1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MOXD1 OriGene 3'-UTR Clone for MOXD1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MOXD1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MOXD1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MOXD1 OriGene Custom Protein Services for MOXD1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MOXD1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MOXD1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOXD1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MOXD1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MOXD1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MOXD1
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MOXD1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOXD1
Search ThermoFisher Antibodies for MOXD1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MOXD1
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