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Aliases for MOXD1 Gene

Aliases for MOXD1 Gene

  • Monooxygenase DBH Like 1 2 3 5
  • Monooxygenase X 3 4
  • MOX 3 4
  • DBH-Like Monooxygenase Protein 1 3
  • Monooxygenase, DBH-Like 1 2
  • Dopamine-Oxygenase 3
  • EC 1.14.17.- 4
  • EC 1.14.17 58
  • DJ248E1.1 3
  • PRO5780 3

External Ids for MOXD1 Gene

Previous GeneCards Identifiers for MOXD1 Gene

  • GC06M132553
  • GC06M132597
  • GC06M132658
  • GC06M130192

Summaries for MOXD1 Gene

GeneCards Summary for MOXD1 Gene

MOXD1 (Monooxygenase DBH Like 1) is a Protein Coding gene. Diseases associated with MOXD1 include Mesenteric Lymphadenitis. GO annotations related to this gene include copper ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen. An important paralog of this gene is DBH.

Gene Wiki entry for MOXD1 Gene

Additional gene information for MOXD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOXD1 Gene

Genomics for MOXD1 Gene

Regulatory Elements for MOXD1 Gene

Enhancers for MOXD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H132365 0.9 ENCODE 17.3 +35.7 35720 0 PKNOX1 TBL1XR1 SIN3A BMI1 FEZF1 BATF ATF7 ETV6 RUNX3 IKZF2 MOXD1 PIR45153
GH06H132489 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -89.3 -89309 2 NFIC PKNOX1 POLR2A NFYB FOXP2 STX7 MOXD1 VNN1 TAAR6 VNN2 TAAR5 SLC18B1
GH06H132369 0.7 Ensembl ENCODE 21.7 +31.8 31808 1 JUND POLR2A MOXD1 PIR45153
GH06H132493 1.3 Ensembl ENCODE dbSUPER 11.1 -95.9 -95854 7 HDGF PKNOX1 TBL1XR1 RB1 BMI1 BATF ZNF207 ATF7 RUNX3 CREM MOXD1 STX7 ENPP1
GH06H132333 1.1 Ensembl ENCODE 12.2 +67.1 67057 1 TBP FOXA2 ATF1 MLX ARID4B SIN3A DNMT3B RARA YY1 ZNF143 MED23 MOXD1 PIR45153 GC06M132077
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MOXD1 on UCSC Golden Path with GeneCards custom track

Promoters for MOXD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000202973 345 801 CTCF MXI1 SUZ12 ZIC2 ZNF2 ZFHX2 GLIS2 ZNF366 POLR2A ZBTB48

Genomic Location for MOXD1 Gene

132,296,055 bp from pter
132,401,545 bp from pter
105,491 bases
Minus strand

Genomic View for MOXD1 Gene

Genes around MOXD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOXD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOXD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOXD1 Gene

Proteins for MOXD1 Gene

  • Protein details for MOXD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DBH-like monooxygenase protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5THU6
    • Q8NC97
    • Q8WV49
    • Q9H4M6
    • Q9Y4U3

    Protein attributes for MOXD1 Gene

    613 amino acids
    Molecular mass:
    69652 Da
    Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
    Quaternary structure:
    No Data Available
    • Sequence=BAC11263.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MOXD1 Gene


neXtProt entry for MOXD1 Gene

Selected DME Specific Peptides for MOXD1 Gene


Post-translational modifications for MOXD1 Gene

Other Protein References for MOXD1 Gene

Domains & Families for MOXD1 Gene

Gene Families for MOXD1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MOXD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the copper type II ascorbate-dependent monooxygenase family.
  • Belongs to the copper type II ascorbate-dependent monooxygenase family.
genes like me logo Genes that share domains with MOXD1: view

Function for MOXD1 Gene

Molecular function for MOXD1 Gene

UniProtKB/Swiss-Prot Induction:
By replicative senescence.

Enzyme Numbers (IUBMB) for MOXD1 Gene

Phenotypes From GWAS Catalog for MOXD1 Gene

Gene Ontology (GO) - Molecular Function for MOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0004500 dopamine beta-monooxygenase activity IBA --
GO:0005507 copper ion binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with MOXD1: view
genes like me logo Genes that share phenotypes with MOXD1: view

Animal Models for MOXD1 Gene

MGI Knock Outs for MOXD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for MOXD1

CRISPR Products

miRNA for MOXD1 Gene

miRTarBase miRNAs that target MOXD1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MOXD1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOXD1 Gene

Localization for MOXD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOXD1 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOXD1 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 4
peroxisome 3
plasma membrane 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IDA 15337741
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MOXD1: view

Pathways & Interactions for MOXD1 Gene

SuperPathways for MOXD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006589 octopamine biosynthetic process IBA --
GO:0042420 dopamine catabolic process IBA --
GO:0042421 norepinephrine biosynthetic process IBA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MOXD1: view

No data available for Pathways by source and SIGNOR curated interactions for MOXD1 Gene

Drugs & Compounds for MOXD1 Gene

(2) Drugs for MOXD1 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved Pharma 188
Nepicastat (SYN-117) HCl Pharma Dopamine-β-hydroxylase inhibitor 0

(1) ApexBio Compounds for MOXD1 Gene

Compound Action Cas Number
Nepicastat (SYN-117) HCl Dopamine-β-hydroxylase inhibitor 170151-24-3
genes like me logo Genes that share compounds with MOXD1: view

Drug Products

Transcripts for MOXD1 Gene

Unigene Clusters for MOXD1 Gene

Monooxygenase, DBH-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MOXD1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MOXD1 Gene

No ASD Table

Relevant External Links for MOXD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MOXD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOXD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOXD1 Gene

This gene is overexpressed in Uterus (x4.7).

Protein differential expression in normal tissues from HIPED for MOXD1 Gene

This gene is overexpressed in Uterus (16.0), Fetal gut (7.8), and Prostate (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MOXD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MOXD1 Gene:


SOURCE GeneReport for Unigene cluster for MOXD1 Gene:


mRNA Expression by UniProt/SwissProt for MOXD1 Gene:

Tissue specificity: Highly expressed in lung, kidney, brain and spinal cord.

Evidence on tissue expression from TISSUES for MOXD1 Gene

  • Nervous system(4.6)
  • Skin(4.4)
  • Liver(4)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with MOXD1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOXD1 Gene

Orthologs for MOXD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MOXD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MOXD1 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia MOXD1 33 34
  • 89.46 (n)
(Bos Taurus)
Mammalia MOXD1 33 34
  • 89.06 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
-- 34
  • 80 (a)
(Mus musculus)
Mammalia Moxd1 33 16 34
  • 84.14 (n)
(Rattus norvegicus)
Mammalia Moxd1 33
  • 84.02 (n)
(Monodelphis domestica)
Mammalia MOXD1 34
  • 81 (a)
(Gallus gallus)
Aves -- 34
  • 78 (a)
LOC777223 33
  • 76.97 (n)
MOXD1 34
  • 75 (a)
(Anolis carolinensis)
Reptilia MOXD1 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia moxd1 33
  • 68.36 (n)
(Danio rerio)
Actinopterygii moxd1 33 34
  • 62.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011613 33
  • 48.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta olf413 33 34
  • 45.37 (n)
CG5235 34
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
Species where no ortholog for MOXD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOXD1 Gene

Gene Tree for MOXD1 (if available)
Gene Tree for MOXD1 (if available)

Paralogs for MOXD1 Gene

Paralogs for MOXD1 Gene

(2) SIMAP similar genes for MOXD1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MOXD1: view

Variants for MOXD1 Gene

Sequence variations from dbSNP and Humsavar for MOXD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000000881 -- 132,333,063(+) CGGGC(A/G)CTGTG intron-variant
rs1000012224 -- 132,356,731(+) GAGGG(C/T)ATTAA intron-variant
rs1000027647 -- 132,338,426(+) ACAAA(A/T)TATAC intron-variant
rs1000067716 -- 132,392,563(+) ATCAG(G/T)GCAAT intron-variant
rs1000080956 -- 132,350,577(+) CTTTT(C/T)GCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOXD1 Gene

Variant ID Type Subtype PubMed ID
dgv10936n54 CNV loss 21841781
dgv10937n54 CNV loss 21841781
dgv10938n54 CNV loss 21841781
dgv10939n54 CNV loss 21841781
dgv10940n54 CNV loss 21841781
dgv10941n54 CNV loss 21841781
dgv10942n54 CNV loss 21841781
dgv3393n106 CNV deletion 24896259
esv1005349 CNV deletion 20482838
esv1048627 CNV deletion 17803354
esv2257358 CNV deletion 18987734
esv23627 CNV loss 19812545
esv2422115 CNV deletion 20811451
esv2669946 CNV deletion 23128226
esv2672404 CNV deletion 23128226
esv2674189 CNV deletion 23128226
esv2732715 CNV deletion 23290073
esv2732716 CNV deletion 23290073
esv2791 CNV loss 18987735
esv3400807 CNV insertion 20981092
esv3540481 CNV deletion 23714750
esv3540483 CNV deletion 23714750
esv3610837 CNV loss 21293372
esv5479 CNV loss 19470904
esv9597 CNV gain 19470904
nsv1074962 CNV deletion 25765185
nsv1125422 OTHER inversion 24896259
nsv1144148 CNV deletion 24896259
nsv442008 CNV loss 18776908
nsv499756 CNV loss 21111241
nsv514389 CNV loss 21397061
nsv5480 CNV deletion 18451855
nsv604668 CNV loss 21841781
nsv604669 CNV loss 21841781
nsv818455 CNV loss 17921354
nsv830811 CNV gain 17160897

Variation tolerance for MOXD1 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOXD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOXD1 Gene

Disorders for MOXD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MOXD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mesenteric lymphadenitis
  • mesenteric adenitis
- elite association - COSMIC cancer census association via MalaCards
Search MOXD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MOXD1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MOXD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOXD1 Gene

Publications for MOXD1 Gene

  1. Monooxygenase X, a member of the copper-dependent monooxygenase family localized to the endoplasmic reticulum. (PMID: 15337741) Xin X … Eipper BA (The Journal of biological chemistry 2004) 3 4 22 60
  2. Identification and cloning of a sequence homologue of dopamine beta-hydroxylase. (PMID: 9751809) Chambers KJ … Funk WD (Gene 1998) 2 3 4 60
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for MOXD1 Gene

Sources for MOXD1 Gene

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