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Aliases for MOV10L1 Gene

Aliases for MOV10L1 Gene

  • Mov10 RISC Complex RNA Helicase Like 1 2 3 5
  • Cardiac Helicase Activated By MEF2C Protein 2 3
  • Moloney Leukemia Virus 10-Like Protein 1 3 4
  • MOV10-Like Protein 1 3 4
  • Mov10l1, Moloney Leukemia Virus 10-Like 1, Homolog (Mouse) 2
  • Mov10l1, Moloney Leukemia Virus 10-Like 1, Homolog 3
  • Putative Helicase Mov10l1 3
  • Mov10 (Mouse)-Like 1 2
  • RNA Helicase Mov10l1 3
  • Mov10-Like 1 3
  • EC 3.6.4.13 4
  • DJ402G11.8 3
  • EC 3.6.1 58
  • CHAMP 3

External Ids for MOV10L1 Gene

Previous GeneCards Identifiers for MOV10L1 Gene

  • GC22P047080
  • GC22P048710
  • GC22P048830
  • GC22P048870
  • GC22P050528
  • GC22P033426

Summaries for MOV10L1 Gene

Entrez Gene Summary for MOV10L1 Gene

  • This gene is similar to a mouse gene that encodes a putative RNA helicase and shows testis-specific expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for MOV10L1 Gene

MOV10L1 (Mov10 RISC Complex RNA Helicase Like 1) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Gene Expression. GO annotations related to this gene include RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is MOV10.

UniProtKB/Swiss-Prot for MOV10L1 Gene

  • ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5-3 RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.

Additional gene information for MOV10L1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOV10L1 Gene

Genomics for MOV10L1 Gene

Regulatory Elements for MOV10L1 Gene

Enhancers for MOV10L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H050117 1.5 Ensembl ENCODE dbSUPER 25.1 +28.9 28851 3 FOXA2 PKNOX1 ATF1 ARNT BRCA1 YY1 TCF12 ZNF766 GATA2 ELK1 MLC1 MOV10L1 ENSG00000273253 PANX2 SELENOO LMF2 ENSG00000280395
GH22H050111 1.5 FANTOM5 Ensembl ENCODE dbSUPER 18.6 +24.1 24131 4 ELF3 TFAP4 JUN POLR2A FOS RCOR1 GATAD2A NFIA HLF GABPA MLC1 MOV10L1 SELENOO ENSG00000280395 PANX2
GH22H050145 1.1 Ensembl ENCODE 19.1 +56.8 56755 2 ELF3 ARID4B THRB RAD21 RARA YY1 GLIS2 ZNF143 CREM MIXL1 MLC1 MOV10L1 MAPK12 PANX2 TUBGCP6 HDAC10 SELENOO MAPK11 PLXNB2 ENSG00000280395
GH22H050084 0.9 Ensembl ENCODE 23.2 -3.8 -3799 3 ZSCAN5A PKNOX1 L3MBTL2 RNF2 CEBPB GABPA ZFHX2 EGR1 CUX1 MGA MLC1 MOV10L1 SELENOO RABL2B
GH22H050148 1.1 Ensembl ENCODE 18.9 +59.3 59345 0 HDAC1 RB1 ARID4B SIN3A RAD21 ZNF366 SCRT2 ZNF143 THAP11 SMARCA5 MLC1 MOV10L1 PANX2 TUBGCP6 HDAC10 SELENOO MAPK12 MAPK11 PLXNB2 TRABD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MOV10L1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MOV10L1 gene promoter:

Genomic Location for MOV10L1 Gene

Chromosome:
22
Start:
50,089,879 bp from pter
End:
50,161,705 bp from pter
Size:
71,827 bases
Orientation:
Plus strand

Genomic View for MOV10L1 Gene

Genes around MOV10L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOV10L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOV10L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOV10L1 Gene

Proteins for MOV10L1 Gene

  • Protein details for MOV10L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXT6-M10L1_HUMAN
    Recommended name:
    RNA helicase Mov10l1
    Protein Accession:
    Q9BXT6
    Secondary Accessions:
    • A7E211
    • A8MXC6
    • B7WPP1
    • B7Z7R1
    • F5H403
    • Q5TGD5
    • Q8NBD4
    • Q9NXW3
    • Q9UFB3
    • Q9UGX9

    Protein attributes for MOV10L1 Gene

    Size:
    1211 amino acids
    Molecular mass:
    135293 Da
    Quaternary structure:
    • Interacts with PIWIL1. Interacts with PIWIL2. Interacts with PIWIL4. Interacts with HSPA2. Interacts with PLD6.

    Alternative splice isoforms for MOV10L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOV10L1 Gene

Selected DME Specific Peptides for MOV10L1 Gene

Q9BXT6:
  • IGVITPY
  • GPPGTGKTV
  • LVCAPSN
  • PYRKQVEKI

Post-translational modifications for MOV10L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MOV10L1 Gene

Gene Families for MOV10L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MOV10L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXT6

UniProtKB/Swiss-Prot:

M10L1_HUMAN :
  • Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
Family:
  • Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
genes like me logo Genes that share domains with MOV10L1: view

Function for MOV10L1 Gene

Molecular function for MOV10L1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5-3 RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.

Enzyme Numbers (IUBMB) for MOV10L1 Gene

Phenotypes From GWAS Catalog for MOV10L1 Gene

Gene Ontology (GO) - Molecular Function for MOV10L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding TAS 11839499
GO:0003723 RNA binding TAS 11839499
GO:0004004 ATP-dependent RNA helicase activity NAS 11279525
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding TAS 11839499
genes like me logo Genes that share ontologies with MOV10L1: view
genes like me logo Genes that share phenotypes with MOV10L1: view

Animal Models for MOV10L1 Gene

MGI Knock Outs for MOV10L1:

Animal Model Products

CRISPR Products

miRNA for MOV10L1 Gene

miRTarBase miRNAs that target MOV10L1

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOV10L1 Gene

Localization for MOV10L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOV10L1 Gene

Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250 UniProtKB:Q99MV5}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOV10L1 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for MOV10L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IC 11839499
GO:0005737 cytoplasm IEA --
GO:0043186 P granule ISS --
GO:0071546 pi-body ISS --
genes like me logo Genes that share ontologies with MOV10L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MOV10L1 Gene

Pathways & Interactions for MOV10L1 Gene

genes like me logo Genes that share pathways with MOV10L1: view

Pathways by source for MOV10L1 Gene

Gene Ontology (GO) - Biological Process for MOV10L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007141 male meiosis I ISS --
GO:0007275 multicellular organism development IEA --
GO:0007281 germ cell development IEP 11279525
GO:0007283 spermatogenesis ISS --
GO:0034587 piRNA metabolic process ISS --
genes like me logo Genes that share ontologies with MOV10L1: view

No data available for SIGNOR curated interactions for MOV10L1 Gene

Drugs & Compounds for MOV10L1 Gene

(3) Drugs for MOV10L1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for MOV10L1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MOV10L1: view

Transcripts for MOV10L1 Gene

Unigene Clusters for MOV10L1 Gene

Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOV10L1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - - -
SP2:
SP3:
SP4: - - -
SP5:
SP6: -
SP7: -
SP8: - - - - -
SP9: - -
SP10:
SP11:
SP12:

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:

Relevant External Links for MOV10L1 Gene

GeneLoc Exon Structure for
MOV10L1
ECgene alternative splicing isoforms for
MOV10L1

Expression for MOV10L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOV10L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOV10L1 Gene

This gene is overexpressed in Testis (x22.6).

Protein differential expression in normal tissues from HIPED for MOV10L1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MOV10L1 Gene



Protein tissue co-expression partners for MOV10L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOV10L1 Gene:

MOV10L1

SOURCE GeneReport for Unigene cluster for MOV10L1 Gene:

Hs.62880

mRNA Expression by UniProt/SwissProt for MOV10L1 Gene:

Q9BXT6-M10L1_HUMAN
Tissue specificity: Isoform 1: Specifically expressed in testis.

Evidence on tissue expression from TISSUES for MOV10L1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MOV10L1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MOV10L1 Gene

Orthologs for MOV10L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOV10L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOV10L1 33
  • 94.71 (n)
dog
(Canis familiaris)
Mammalia MOV10L1 33 34
  • 83.08 (n)
cow
(Bos Taurus)
Mammalia MOV10L1 33 34
  • 81.61 (n)
rat
(Rattus norvegicus)
Mammalia Mov10l1 33
  • 81.45 (n)
mouse
(Mus musculus)
Mammalia Mov10l1 33 16 34
  • 81.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MOV10L1 34
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MOV10L1 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOV10L1 33 34
  • 62.58 (n)
lizard
(Anolis carolinensis)
Reptilia MOV10L1 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mov10l1 33
  • 62.26 (n)
Str.19559 33
zebrafish
(Danio rerio)
Actinopterygii zgc:154086 33
  • 56.02 (n)
MOV10L1 34
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6701 35
  • 35 (a)
CG6967 35
  • 35 (a)
CG11513 35
  • 33 (a)
armi 34
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM7 34
  • 17 (a)
OneToMany
Species where no ortholog for MOV10L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOV10L1 Gene

ENSEMBL:
Gene Tree for MOV10L1 (if available)
TreeFam:
Gene Tree for MOV10L1 (if available)

Paralogs for MOV10L1 Gene

Paralogs for MOV10L1 Gene

(2) SIMAP similar genes for MOV10L1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MOV10L1: view

Variants for MOV10L1 Gene

Sequence variations from dbSNP and Humsavar for MOV10L1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000026658 -- 50,119,809(+) TCTTG(A/G)GTGAG intron-variant
rs1000057140 -- 50,150,441(+) ATAGA(C/T)GGCAT intron-variant
rs1000120304 -- 50,121,040(+) GGAGA(C/T)AGAGG intron-variant, upstream-variant-2KB
rs1000138946 -- 50,152,681(+) GCTGT(G/T)TCCAG intron-variant
rs1000142987 -- 50,154,186(+) AGGCA(C/G)GTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOV10L1 Gene

Variant ID Type Subtype PubMed ID
dgv1336e212 CNV loss 25503493
dgv582n27 CNV gain 19166990
dgv781n67 CNV gain 20364138
dgv8137n54 CNV gain 21841781
esv1005534 CNV deletion 20482838
esv1422199 CNV deletion 17803354
esv1452786 CNV insertion 17803354
esv2724747 CNV deletion 23290073
esv3023790 CNV deletion 24192839
esv33533 CNV loss 17666407
esv3568505 CNV loss 25503493
esv3648084 CNV loss 21293372
esv3648085 CNV loss 21293372
nsv1067062 CNV gain 25217958
nsv1116964 CNV deletion 24896259
nsv1141803 CNV insertion 24896259
nsv471222 CNV gain 18288195
nsv834236 CNV loss 17160897
nsv955199 CNV deletion 24416366

Variation tolerance for MOV10L1 Gene

Residual Variation Intolerance Score: 4.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.41; 98.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOV10L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOV10L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOV10L1 Gene

Disorders for MOV10L1 Gene

Relevant External Links for MOV10L1

Genetic Association Database (GAD)
MOV10L1
Human Genome Epidemiology (HuGE) Navigator
MOV10L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOV10L1

No disorders were found for MOV10L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOV10L1 Gene

Publications for MOV10L1 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang PJ … Page DC (Nature genetics 2001) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 60
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 60

Products for MOV10L1 Gene

Sources for MOV10L1 Gene

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