Aliases for MOV10L1 Gene
- Mov10 RISC Complex RNA Helicase Like 1 2 3 5
- Cardiac Helicase Activated By MEF2C Protein 2 3
- Moloney Leukemia Virus 10-Like Protein 1 3 4
- MOV10-Like Protein 1 3 4
- Mov10l1, Moloney Leukemia Virus 10-Like 1, Homolog (Mouse) 2
- Mov10l1, Moloney Leukemia Virus 10-Like 1, Homolog 3
- Putative Helicase Mov10l1 3
External Ids for MOV10L1 Gene
Previous GeneCards Identifiers for MOV10L1 Gene
This gene is similar to a mouse gene that encodes a putative RNA helicase and shows testis-specific expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
GeneCards Summary for MOV10L1 Gene
MOV10L1 (Mov10 RISC Complex RNA Helicase Like 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Formation of the HIV-1 Early Elongation Complex. GO annotations related to this gene include RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is UPF1.
UniProtKB/Swiss-Prot for MOV10L1 Gene
ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNAs metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5-3 RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.