Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MOV10L1 Gene

protein-coding   GIFtS: 50
GCID: GC22P050528

Mov10l1, Moloney Leukemia Virus 10-Like 1, Homolog (Mouse)

(Previous name: Mov10 (mouse)-like 1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Mov10l1, Moloney Leukemia Virus 10-Like 1, Homolog (Mouse)1 2     DJ402G11.82
Cardiac Helicase Activated By MEF2C Protein1 2     Mov10-Like 12
Moloney Leukemia Virus 10-Like Protein 12 3     Putative Helicase Mov10l12
MOV10-Like Protein 12 3     EC 3.6.4.133
Mov10 (Mouse)-Like 11     EC 3.6.18
CHAMP2     

External Ids:    HGNC: 72011   Entrez Gene: 544562   Ensembl: ENSG000000731467   OMIM: 6057945   UniProtKB: Q9BXT63   

Export aliases for MOV10L1 gene to outside databases

Previous GC identifers: GC22P047080 GC22P048710 GC22P048830 GC22P048870 GC22P033426


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MOV10L1 Gene:
This gene is similar to a mouse gene that encodes a putative RNA helicase and shows testis-specific expression.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug
2009)

GeneCards Summary for MOV10L1 Gene:
MOV10L1 (Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)) is a protein-coding gene. GO annotations related to this gene include RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is HELZ.

UniProtKB/Swiss-Prot: M10L1_HUMAN, Q9BXT6
Function: Putative RNA helicase. Isoform 1 may play a role in male germ cell development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011526.8  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MOV10L1 gene promoter:
         CREB   AML1a   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOV10L1 promoter sequence
   Search Chromatin IP Primers for MOV10L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MOV10L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

MOV10L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOV10L1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P050528:  view genomic region     (about GC identifiers)

Start:
50,528,308 bp from pter      End:
50,600,119 bp from pter
Size:
71,812 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: M10L1_HUMAN, Q9BXT6 (See protein sequence)
Recommended Name: Putative helicase Mov10l1  
Size: 1211 amino acids; 135293 Da
Secondary accessions: A7E211 A8MXC6 B7WPP1 B7Z7R1 F5H403 Q5TGD5 Q8NBD4 Q9NXW3 Q9UFB3 Q9UGX9
Alternative splicing: 5 isoforms:  Q9BXT6-1   Q9BXT6-2   Q9BXT6-3   Q9BXT6-4   Q9BXT6-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MOV10L1: NX_Q9BXT6

Explore proteomics data for MOV10L1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for MOV10L1 (Q9BXT6)
     LVCAPSN  IGVITPY  GPPGTGKTV  PYRKQVEKI 


    See MOV10L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001157576.1  NP_001157577.1  NP_001157578.1  NP_061868.1  

    ENSEMBL proteins: 
     ENSP00000262794   ENSP00000410957   ENSP00000379195   ENSP00000379199   ENSP00000399776  
     ENSP00000379193   ENSP00000346917   ENSP00000438978   ENSP00000438542   ENSP00000379184  

    MOV10L1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MOV10L1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MOV10L1
    GenScript Custom Purified and Recombinant Proteins Services for MOV10L1
    Novus Biologicals MOV10L1 Protein
    Novus Biologicals MOV10L1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MOV10L1

     
    Search eBioscience for Proteins for MOV10L1 

    MOV10L1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MOV10L1
    OriGene Custom Antibody Services for MOV10L1
    Novus Biologicals MOV10L1 Antibodies
    Abcam antibodies for MOV10L1
    Cloud-Clone Corp. Antibodies for MOV10L1
    Search ThermoFisher Antibodies for MOV10L1
    LSBio Antibodies in human, mouse, rat for MOV10L1

    MOV10L1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MOV10L1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MOV10L1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MOV10L1
    Cloud-Clone Corp. CLIAs for MOV10L1
    Search eBioscience for ELISAs for MOV10L1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR026125 MOV10L1
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9BXT6

    ProtoNet protein and cluster: Q9BXT6

    UniProtKB/Swiss-Prot: M10L1_HUMAN, Q9BXT6
    Similarity: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily


    Find genes that share domains with MOV10L1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M10L1_HUMAN, Q9BXT6
    Function: Putative RNA helicase. Isoform 1 may play a role in male germ cell development
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding TAS11839499
    GO:0003723RNA binding TAS11839499
    GO:0004004ATP-dependent RNA helicase activity NAS11279525
    GO:0005524ATP binding TAS11839499
         
    Find genes that share ontologies with MOV10L1           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mov10l1):
     cellular  endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with MOV10L1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mov10l1tm1.2Jw for MOV10L1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MOV10L1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MOV10L1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MOV10L1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MOV10L1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MOV10L1:
    hsa-mir-500a-5p (MIRT037994), hsa-mir-335-5p (MIRT018957)

    Block miRNA regulation of human, mouse, rat MOV10L1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MOV10L1
    SwitchGear 3'UTR luciferase reporter plasmidMOV10L1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MOV10L1
    Predesigned siRNA for gene silencing in human, mouse, rat MOV10L1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MOV10L1

    Clone
    Products:
         
    OriGene clones in human, mouse for MOV10L1 (see all 22)
    OriGene ORF clones in mouse, rat for MOV10L1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MOV10L1 (NM_018995)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOV10L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOV10L1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MOV10L1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MOV10L1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOV10L1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IC11839499

    Find genes that share ontologies with MOV10L1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MOV10L1
    Interactions:

        Search GeneGlobe Interaction Network for MOV10L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MOV10L1 (Q9BXT63 ENSP000002627944) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCP1BQ8IZD43, ENSP000002806654I2D: score=1 STRING: ENSP00000280665
    PIWIL1Q96J943, ENSP000002452554I2D: score=2 STRING: ENSP00000245255
    NCAM2O153943I2D: score=1 
    CASC3ENSP000002646454STRING: ENSP00000264645
    TDRD3ENSP000001961694STRING: ENSP00000196169
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process NAS11279525
    GO:0007275multicellular organismal development IEA--
    GO:0007281germ cell development IEP11279525
    GO:0007283spermatogenesis IEP11279525

    Find genes that share ontologies with MOV10L1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MOV10L1 (M10L1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MOV10L1 gene (4 alternative transcripts): 
    NM_001164104.1  NM_001164105.1  NM_001164106.1  NM_018995.2  

    Unigene Cluster for MOV10L1:

    Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)
    Hs.62880  [show with all ESTs]
    Unigene Representative Sequence: NM_018995
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262794(uc003bjj.3 uc003bjk.4) ENST00000419054 ENST00000395854(uc010han.3)
    ENST00000395858 ENST00000475190 ENST00000434497 ENST00000395852(uc003bjl.3)
    ENST00000354853(uc003bjm.1) ENST00000545383 ENST00000540615(uc011arp.2)
    ENST00000395843(uc011arq.1 uc010hao.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MOV10L1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MOV10L1
    SwitchGear 3'UTR luciferase reporter plasmidMOV10L1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MOV10L1
    Predesigned siRNA for gene silencing in human, mouse, rat MOV10L1
    Clone
    Products:
         
    OriGene clones in human, mouse for MOV10L1 (see all 22)
    OriGene ORF clones in mouse, rat for MOV10L1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MOV10L1 (NM_018995)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOV10L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOV10L1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MOV10L1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MOV10L1
      QuantiTect SYBR Green Assays in human, mouse, rat MOV10L1
      QuantiFast Probe-based Assays in human, mouse, rat MOV10L1

    Additional mRNA sequence: 

    AF285604.1 AK000033.1 AK090740.1 AK092675.1 AK302401.1 AK303017.1 AK307675.1 AL133068.2 
    BC029552.1 BC042828.1 BC063837.1 BC140944.1 BC150137.1 BC152539.1 CR456466.1 

    9 DOTS entries:

    DT.91897464  DT.403031  DT.95255595  DT.97838454  DT.97838455  DT.91955250  DT.99961352  DT.120641082 
    DT.99996172 

    Selected AceView cDNA sequences (see all 48):

    BM931997 BX100306 AA412094 CR456466 CK299989 BQ186899 BM685033 BM681571 
    BQ879286 BV203493 BX116700 BM726400 AA628983 AX747666 BV198074 AK000033 
    AF285604 BU171206 AX746595 AA609579 AW263274 BC042828 AL133068 AI209130 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MOV10L1 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
    SP1:              -     -     -                             -                       -                                                                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                    -     -     -                           
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c
    SP1:                                            -     -                                                                           
    SP2:                                            -     -                                               -                           
    SP3:                                                  -                                                                           
    SP4:                                                                                                                              
    SP5:                                                                                            -                                 


    ECgene alternative splicing isoforms for MOV10L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MOV10L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MOV10L1 Expression
    About this image


    MOV10L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Gonad
             XY Germ Cells Testis Cord
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
    MOV10L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MOV10L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.62880

    UniProtKB/Swiss-Prot: M10L1_HUMAN, Q9BXT6
    Tissue specificity: Isoform 1 is specifically expressed in testis

        Custom PCR Arrays for MOV10L1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MOV10L1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MOV10L1
    QuantiTect SYBR Green Assays in human, mouse, rat MOV10L1
    QuantiFast Probe-based Assays in human, mouse, rat MOV10L1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOV10L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MOV10L1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mov10l11 , 5 Moloney leukemia virus 10-like 11, 5 81.24(n)1
    82.77(a)1
      15 (44.49 cM)5
    834561  NM_031260.21  NP_112550.21 
     889829095 
    chicken
    (Gallus gallus)
    Aves MOV10L11 Mov10l1, Moloney leukemia virus 10-like 1, homolog more 62.58(n)
    59.57(a)
      417738  XM_003640345.2  XP_003640393.2 
    lizard
    (Anolis carolinensis)
    Reptilia MOV10L16
    Mov10l1, Moloney leukemia virus 10-like 1, homolog...
    58(a)
    1 ↔ 1
    5(63832997-63889886)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW635540.12   -- 74.75(n)    AW635540.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI673003.12   -- 77.17(n)    BI673003.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67013   -- 35(a)
    (best of 3)
        --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NAM76
    ATP-dependent RNA helicase of the SFI superfamily ...
    17(a)
    1 → many
    XIII(426712-429627) YMR080C


    ENSEMBL Gene Tree for MOV10L1 (if available)
    TreeFam Gene Tree for MOV10L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MOV10L1 gene
    HELZ2  HELZ22  MOV102  UPF12  ZGRF12  
    2 SIMAP similar genes for MOV10L1 using alignment to 5 protein entries:     M10L1_HUMAN (see all proteins):
    CT55    MOV10

    Find genes that share paralogs with MOV10L1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MOV10L1 (see all 2143)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs713170011,2
    C--34513059(+) AAAAA-/AG/G  
            
    AAAAT
    3 -- int11NA 2
    rs1913277301,2
    --50526728(+) TAAGTC/TGGGGC 3 -- us2k10--------
    rs1826794401,2
    --50526739(+) TGGGCA/GCAGTG 3 -- us2k10--------
    rs60101671,2
    C,F,A--50526741(+) GGCGCG/AGTGGC 3 -- us2k17Minor allele frequency- A:0.49NA WA CSA EA 249
    rs1876716141,2
    --50526793(+) GATCAA/CCTGCG 3 -- us2k10--------
    rs1932076401,2
    --50526797(+) ACCTGC/TGGGTC 3 -- us2k10--------
    rs1379371,2
    C,F--50526840(+) aaaccC/Ttgtcg 3 -- us2k17Minor allele frequency- T:0.00MN NA WA CSA 195
    rs1847401511,2
    --50526915(+) CCTGTA/TATCCC 3 -- us2k10--------
    rs1409316861,2
    --50527018(+) GCGACA/GGAGCA 3 -- us2k10--------
    rs716880621,2
    C--50527036(+) ATCTC-/AAAAAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for MOV10L1 (50528308 - 50600119 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MOV10L1 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1005534CNV Deletion20482838
    esv1422199CNV Deletion17803354
    esv2724747CNV Deletion23290073
    esv1452786CNV Insertion17803354
    nsv915495CNV Loss21882294
    dgv5053n71CNV Loss21882294
    nsv915519CNV Loss21882294
    nsv915523CNV Loss21882294
    dgv5054n71CNV Loss21882294
    dgv5049n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MOV10L1
    DNA2.0 Custom Variant and Variant Library Synthesis for MOV10L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605794    OMIM disorders: --


    Find genes that share disorders with MOV10L1           About GenesLikeMe

    Genetic Association Database (GAD): MOV10L1
    Human Genome Epidemiology (HuGE) Navigator: MOV10L1 (1 document)

    Export disorders for MOV10L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MOV10L1 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with MOV10L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525)1, 2, 3 Wang P.J.... Page D.C. (Nat. Genet. 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    6. A genome-wide association study of behavioral disinhibition. (PubMed id 23942779)1 McGue M....Iacono W.G. (Behav. Genet. 2013)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54456 HGNC: 7201 AceView: MOV10L1 Ensembl:ENSG00000073146 euGenes: HUgn54456
    ECgene: MOV10L1 H-InvDB: MOV10L1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MOV10L1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MOV10L1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MOV10L1 gene:
    Search GeneIP for patents involving MOV10L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MOV10L1   OriGene RNAi products in human, mouse, rat for MOV10L1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MOV10L1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MOV10L1  
     OriGene qSTAR qPCR primer pairs in human, mouse for MOV10L1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MOV10L1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MOV10L1   OriGene Custom Protein Services for MOV10L1  

     
     
     Block miRNA regulation of human, mouse, rat MOV10L1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MOV10L1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MOV10L1 Predesigned siRNA for gene silencing in human, mouse, rat MOV10L1
     QuantiFast Probe-based Assays in human, mouse, rat MOV10L1 QuantiTect SYBR Green Assays in human, mouse, rat MOV10L1
     Custom PCR Arrays for MOV10L1 Search Chromatin IP Primers for MOV10L1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MOV10L1  Search GeneGlobe Interaction Network for MOV10L1
     Regulatory tfbs in MOV10L1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MOV10L1 GenScript cDNA clones with any tag delivered in your preferred vector for MOV10L1
     GenScript Custom Assay Services for MOV10L1 GenScript Custom overexpressing Cell Line Services for MOV10L1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MOV10L1 (M10L1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MOV10L1 antibodies
     MOV10L1 proteins
     MOV10L1 lysates
     Antibodies for MOV10L1
     See all of Abcam's Antibodies, Kits and Proteins for MOV10L1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MOV10L1
     Antibodies for MOV10L1
     ELISAs for MOV10L1
     CLIAs for MOV10L1



     Browse ESI BIO Cell Lines and PureStem Progenitors for MOV10L1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOV10L1
     SwitchGear 3'UTR luciferase reporter plasmids for MOV10L1
     SwitchGear Promoter luciferase reporter plasmids for MOV10L1
     Search ThermoFisher Antibodies for MOV10L1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOV10L1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MOV10L1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MOV10L1
     LSBio Antibodies in human, mouse, rat for MOV10L1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for MOV10L1
      Search eBioscience for proteins for MOV10L1
      Search eBioscience for elisas for MOV10L1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MOV10L1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4