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Aliases for MOV10L1 Gene

Aliases for MOV10L1 Gene

  • Mov10 RISC Complex RNA Helicase Like 1 2 3 5
  • Cardiac Helicase Activated By MEF2C Protein 2 3
  • Moloney Leukemia Virus 10-Like Protein 1 3 4
  • MOV10-Like Protein 1 3 4
  • Mov10l1, Moloney Leukemia Virus 10-Like 1, Homolog (Mouse) 2
  • Mov10l1, Moloney Leukemia Virus 10-Like 1, Homolog 3
  • Putative Helicase Mov10l1 3
  • Mov10 (Mouse)-Like 1 2
  • Mov10-Like 1 3
  • EC 3.6.4.13 4
  • DJ402G11.8 3
  • EC 3.6.1 63
  • CHAMP 3

External Ids for MOV10L1 Gene

Previous GeneCards Identifiers for MOV10L1 Gene

  • GC22P047080
  • GC22P048710
  • GC22P048830
  • GC22P048870
  • GC22P050528
  • GC22P033426

Summaries for MOV10L1 Gene

Entrez Gene Summary for MOV10L1 Gene

  • This gene is similar to a mouse gene that encodes a putative RNA helicase and shows testis-specific expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for MOV10L1 Gene

MOV10L1 (Mov10 RISC Complex RNA Helicase Like 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Formation of the HIV-1 Early Elongation Complex. GO annotations related to this gene include RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is UPF1.

UniProtKB/Swiss-Prot for MOV10L1 Gene

  • ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNAs metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5-3 RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOV10L1 Gene

Genomics for MOV10L1 Gene

Regulatory Elements for MOV10L1 Gene

Enhancers for MOV10L1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MOV10L1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MOV10L1 gene promoter:

Genomic Location for MOV10L1 Gene

Chromosome:
22
Start:
50,089,879 bp from pter
End:
50,161,705 bp from pter
Size:
71,827 bases
Orientation:
Plus strand

Genomic View for MOV10L1 Gene

Genes around MOV10L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOV10L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOV10L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOV10L1 Gene

Proteins for MOV10L1 Gene

  • Protein details for MOV10L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXT6-M10L1_HUMAN
    Recommended name:
    RNA helicase Mov10l1
    Protein Accession:
    Q9BXT6
    Secondary Accessions:
    • A7E211
    • A8MXC6
    • B7WPP1
    • B7Z7R1
    • F5H403
    • Q5TGD5
    • Q8NBD4
    • Q9NXW3
    • Q9UFB3
    • Q9UGX9

    Protein attributes for MOV10L1 Gene

    Size:
    1211 amino acids
    Molecular mass:
    135293 Da
    Quaternary structure:
    • Interacts with PIWIL1. Interacts with PIWIL2. Interacts with PIWIL4. Interacts with HSPA2. Interacts with PLD6.

    Alternative splice isoforms for MOV10L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOV10L1 Gene

Proteomics data for MOV10L1 Gene at MOPED

Selected DME Specific Peptides for MOV10L1 Gene

Post-translational modifications for MOV10L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for MOV10L1 Gene

Gene Families for MOV10L1 Gene

Protein Domains for MOV10L1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BXT6

UniProtKB/Swiss-Prot:

M10L1_HUMAN :
  • Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
Family:
  • Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
genes like me logo Genes that share domains with MOV10L1: view

Function for MOV10L1 Gene

Molecular function for MOV10L1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNAs metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5-3 RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.

Enzyme Numbers (IUBMB) for MOV10L1 Gene

genes like me logo Genes that share phenotypes with MOV10L1: view

Animal Models for MOV10L1 Gene

MGI Knock Outs for MOV10L1:

Animal Model Products

CRISPR Products

miRNA for MOV10L1 Gene

miRTarBase miRNAs that target MOV10L1

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOV10L1 Gene

Localization for MOV10L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOV10L1 Gene

Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250 UniProtKB:Q99MV5}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOV10L1 Gene COMPARTMENTS Subcellular localization image for MOV10L1 gene
Compartment Confidence
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for MOV10L1 Gene

Pathways & Interactions for MOV10L1 Gene

genes like me logo Genes that share pathways with MOV10L1: view

Pathways by source for MOV10L1 Gene

Gene Ontology (GO) - Biological Process for MOV10L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEP,ISS --
GO:0034587 piRNA metabolic process ISS,TAS --
genes like me logo Genes that share ontologies with MOV10L1: view

No data available for SIGNOR curated interactions for MOV10L1 Gene

Drugs & Compounds for MOV10L1 Gene

(1) Drugs for MOV10L1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for MOV10L1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with MOV10L1: view

Transcripts for MOV10L1 Gene

Unigene Clusters for MOV10L1 Gene

Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOV10L1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - - -
SP2:
SP3:
SP4: - - -
SP5:
SP6: -
SP7: -
SP8: - - - - -
SP9: - -
SP10:
SP11:
SP12:

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:

Relevant External Links for MOV10L1 Gene

GeneLoc Exon Structure for
MOV10L1
ECgene alternative splicing isoforms for
MOV10L1

Expression for MOV10L1 Gene

mRNA expression in normal human tissues for MOV10L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOV10L1 Gene

This gene is overexpressed in Testis (x22.6).

Protein differential expression in normal tissues from HIPED for MOV10L1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MOV10L1 Gene



SOURCE GeneReport for Unigene cluster for MOV10L1 Gene Hs.62880

mRNA Expression by UniProt/SwissProt for MOV10L1 Gene

Q9BXT6-M10L1_HUMAN
Tissue specificity: Isoform 1 is specifically expressed in testis.
genes like me logo Genes that share expression patterns with MOV10L1: view

Protein tissue co-expression partners for MOV10L1 Gene

- Elite partner

Primer Products

Orthologs for MOV10L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOV10L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MOV10L1 35
  • 81.61 (n)
  • 82.46 (a)
MOV10L1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOV10L1 35
  • 83.08 (n)
  • 82.91 (a)
MOV10L1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mov10l1 35
  • 81.24 (n)
  • 82.77 (a)
Mov10l1 16
Mov10l1 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MOV10L1 35
  • 94.71 (n)
  • 92.65 (a)
rat
(Rattus norvegicus)
Mammalia Mov10l1 35
  • 81.45 (n)
  • 82.82 (a)
oppossum
(Monodelphis domestica)
Mammalia MOV10L1 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MOV10L1 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOV10L1 35
  • 62.58 (n)
  • 59.57 (a)
MOV10L1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MOV10L1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mov10l1 35
  • 62.26 (n)
  • 60.47 (a)
Str.19559 35
zebrafish
(Danio rerio)
Actinopterygii zgc:154086 35
  • 56.02 (n)
  • 53.43 (a)
MOV10L1 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11513 37
  • 33 (a)
CG6701 37
  • 35 (a)
CG6967 37
  • 35 (a)
armi 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM7 36
  • 17 (a)
OneToMany
Species with no ortholog for MOV10L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOV10L1 Gene

ENSEMBL:
Gene Tree for MOV10L1 (if available)
TreeFam:
Gene Tree for MOV10L1 (if available)

Paralogs for MOV10L1 Gene

Paralogs for MOV10L1 Gene

(2) SIMAP similar genes for MOV10L1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MOV10L1: view

Variants for MOV10L1 Gene

Sequence variations from dbSNP and Humsavar for MOV10L1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs760749 - 50,117,257(+) CACTA(A/C)TTGCT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs2340601 - 50,134,044(+) AACAC(A/G)TCATC nc-transcript-variant, reference, missense
rs2272837 - 50,144,197(+) GCTAC(A/G)GCCGG nc-transcript-variant, reference, missense
rs2272843 - 50,161,037(+) TCCTG(A/C)ACTGC intron-variant, reference, missense
rs3810971 - 50,108,237(+) ACAAG(C/T)GCGTG nc-transcript-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MOV10L1 Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
dgv5049n71 CNV Loss 21882294
nsv915508 CNV Loss 21882294
dgv5051n71 CNV Loss 21882294
dgv5053n71 CNV Loss 21882294
nsv915519 CNV Loss 21882294
dgv582n27 CNV Gain 19166990
nsv471222 CNV Gain 18288195
nsv915521 CNV Loss 21882294
nsv915523 CNV Loss 21882294
nsv834236 CNV Loss 17160897
esv33533 CNV Loss 17666407
dgv5054n71 CNV Loss 21882294
esv1452786 CNV Insertion 17803354
nsv915525 CNV Loss 21882294
esv1005534 CNV Deletion 20482838
esv1422199 CNV Deletion 17803354
esv2724747 CNV Deletion 23290073
dgv781n67 CNV Gain 20364138

Variation tolerance for MOV10L1 Gene

Residual Variation Intolerance Score: 4.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.41; 98.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MOV10L1 Gene

Disorders for MOV10L1 Gene

Relevant External Links for MOV10L1

Genetic Association Database (GAD)
MOV10L1
Human Genome Epidemiology (HuGE) Navigator
MOV10L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOV10L1

No disorders were found for MOV10L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOV10L1 Gene

Publications for MOV10L1 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Association of MOV10L1 gene polymorphisms and male infertility in azoospermic men with complete maturation arrest. (PMID: 24817005) Sarkardeh H. … Gourabi H. (J. Assist. Reprod. Genet. 2014) 3
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  5. A genome-wide association study of behavioral disinhibition. (PMID: 23942779) McGue M. … Iacono W.G. (Behav. Genet. 2013) 3

Products for MOV10L1 Gene

Sources for MOV10L1 Gene

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