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Aliases for MOV10 Gene

Aliases for MOV10 Gene

  • Mov10 RISC Complex RNA Helicase 2 3 5
  • Functional Spliceosome-Associated Protein 113 2 3
  • Moloney Leukemia Virus 10 Protein 3 4
  • Armitage Homolog 3 4
  • Mov10, Moloney Leukemia Virus 10, Homolog (Mouse) 2
  • Mov10 (Moloney Leukemia Virus 10, Mouse) Homolog 2
  • Mov10, Moloney Leukemia Virus 10, Homolog 3
  • Putative Helicase MOV-10 3
  • EC 3.6.4.13 4
  • KIAA1631 4
  • EC 3.6.1 61
  • FSAP113 3
  • Gb110 3

External Ids for MOV10 Gene

Previous GeneCards Identifiers for MOV10 Gene

  • GC01P113631
  • GC01P112101
  • GC01P112319
  • GC01P112516
  • GC01P112929
  • GC01P113018
  • GC01P113215
  • GC01P111075

Summaries for MOV10 Gene

GeneCards Summary for MOV10 Gene

MOV10 (Mov10 RISC Complex RNA Helicase) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Innate Immune System. GO annotations related to this gene include poly(A) RNA binding and helicase activity. An important paralog of this gene is MOV10L1.

UniProtKB/Swiss-Prot for MOV10 Gene

  • Probable RNA helicase. Required for miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC.

  • (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.

Gene Wiki entry for MOV10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOV10 Gene

Genomics for MOV10 Gene

Regulatory Elements for MOV10 Gene

Enhancers for MOV10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G112816 1.5 Ensembl ENCODE dbSUPER 9.9 +146.6 146628 6.8 HDGF PKNOX1 FOXA2 ARNT FEZF1 ZNF2 ZNF766 FOS JUNB ZNF592 PPM1J RHOC LOC100996251 LRIG2 ENSG00000225075 MOV10 KCND3 LINC01356 HP08777 GC01P112820
GH01G112617 1.4 ENCODE dbSUPER 10.6 -52.8 -52829 6.2 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ST7L CAPZA1 LOC100421402 MOV10 ENSG00000225075 RHOC PPM1J CTTNBP2NL
GH01G112402 1.4 Ensembl ENCODE dbSUPER 9.6 -269.4 -269383 4.3 ATF1 BRCA1 ZNF2 KLF7 FOS JUNB TSHZ1 KAT8 MEF2D MAFF WNT2B ENSG00000238761 RHOC PPM1J CTTNBP2NL MOV10 ENSG00000225075 GC01P112397 MIR4256
GH01G112714 1.1 ENCODE 11.1 +42.4 42353 3.0 HDGF PKNOX1 ARNT AGO1 WRNIP1 ARID4B ZNF2 YY1 ZNF143 KLF13 PPM1J MOV10 CTTNBP2NL GC01P112725
GH01G112501 1.1 Ensembl ENCODE 10.9 -171.0 -170958 1.2 RB1 ZSCAN4 SIN3A ZNF48 RAD21 GLIS2 ZNF143 EGR2 ZNF263 ZEB2 ST7L CTTNBP2NL MOV10 ENSG00000225075 CAPZA1 RHOC PPM1J ENSG00000238761 WNT2B GC01P112499
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MOV10 on UCSC Golden Path with GeneCards custom track

Promoters for MOV10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000011509 1959 1801 HDGF FOXA2 PKNOX1 CREB3L1 ARNT MLX AGO1 ARID4B SIN3A FEZF1

Genomic Location for MOV10 Gene

Chromosome:
1
Start:
112,673,141 bp from pter
End:
112,700,746 bp from pter
Size:
27,606 bases
Orientation:
Plus strand

Genomic View for MOV10 Gene

Genes around MOV10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOV10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOV10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOV10 Gene

Proteins for MOV10 Gene

  • Protein details for MOV10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCE1-MOV10_HUMAN
    Recommended name:
    Putative helicase MOV-10
    Protein Accession:
    Q9HCE1
    Secondary Accessions:
    • Q5JR03
    • Q8TEF0
    • Q9BSY3
    • Q9BUJ9

    Protein attributes for MOV10 Gene

    Size:
    1003 amino acids
    Molecular mass:
    113671 Da
    Quaternary structure:
    • Interacts with DICER1, AGO2, TARBP2, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC) (PubMed:17507929). Interacts with APOBEC3G in an RNA-dependent manner.
    • (Microbial infection) Interacts with the human hepatitis delta virus (HDV) antigen HDAg.
    SequenceCaution:
    • Sequence=BAB13457.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB85000.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MOV10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOV10 Gene

Selected DME Specific Peptides for MOV10 Gene

Q9HCE1:
  • VLAGDPRQLGPV
  • QFITKLL
  • PIIFHGV
  • GQLVLAGDP
  • GPPGTGKTV
  • PYRKQVEKI
  • LGFLKNPKR

Post-translational modifications for MOV10 Gene

  • Ubiquitination at posLast=109109, Lys121, posLast=281281, posLast=489489, posLast=530530, posLast=547547, Lys602, posLast=695695, posLast=727727, posLast=846846, posLast=858858, and Lys967
  • Modification sites at PhosphoSitePlus

Domains & Families for MOV10 Gene

Gene Families for MOV10 Gene

Protein Domains for MOV10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MOV10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCE1

UniProtKB/Swiss-Prot:

MOV10_HUMAN :
  • Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
Family:
  • Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
genes like me logo Genes that share domains with MOV10: view

Function for MOV10 Gene

Molecular function for MOV10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable RNA helicase. Required for miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.

Enzyme Numbers (IUBMB) for MOV10 Gene

Gene Ontology (GO) - Molecular Function for MOV10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IDA 22658674
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 16289642
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MOV10: view

Phenotypes for MOV10 Gene

genes like me logo Genes that share phenotypes with MOV10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MOV10

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOV10 Gene

Localization for MOV10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOV10 Gene

Cytoplasm, P-body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOV10 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MOV10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA,IDA 16289642
GO:0005615 extracellular space IDA 22664934
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MOV10: view

Pathways & Interactions for MOV10 Gene

genes like me logo Genes that share pathways with MOV10: view

Gene Ontology (GO) - Biological Process for MOV10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
GO:0031047 gene silencing by RNA IEA --
GO:0035195 gene silencing by miRNA IMP 17507929
genes like me logo Genes that share ontologies with MOV10: view

No data available for SIGNOR curated interactions for MOV10 Gene

Drugs & Compounds for MOV10 Gene

(3) Drugs for MOV10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MOV10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MOV10: view

Transcripts for MOV10 Gene

Unigene Clusters for MOV10 Gene

Mov10, Moloney leukemia virus 10, homolog (mouse):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MOV10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOV10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ·
SP1: - - - - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5:
SP6:
SP7:
SP8: - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - -
SP18: - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - -
SP20:
SP21: - - - - - - -
SP22: - - - - - - -
SP23: -
SP24:
SP25: - - - - - - - - - - -

ExUns: 11e ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c ^ 25a · 25b · 25c · 25d ^ 26a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - - - -
SP6: - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24: -
SP25:

ExUns: 26b ^ 27a · 27b ^ 28 ^ 29a · 29b
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for MOV10 Gene

GeneLoc Exon Structure for
MOV10
ECgene alternative splicing isoforms for
MOV10

Expression for MOV10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOV10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MOV10 Gene

This gene is overexpressed in Bone marrow stromal cell (13.5) and Fetal Liver (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MOV10 Gene



Protein tissue co-expression partners for MOV10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOV10 Gene:

MOV10

SOURCE GeneReport for Unigene cluster for MOV10 Gene:

Hs.514941

Evidence on tissue expression from TISSUES for MOV10 Gene

  • Nervous system(4.8)
  • Lung(4.5)
  • Liver(4.4)
  • Skin(4.3)
  • Spleen(4.3)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with MOV10: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOV10 Gene

Orthologs for MOV10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOV10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOV10 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia MOV10 34 35
  • 90.46 (n)
cow
(Bos Taurus)
Mammalia MOV10 34 35
  • 90.33 (n)
mouse
(Mus musculus)
Mammalia Mov10 34 16 35
  • 88.04 (n)
rat
(Rattus norvegicus)
Mammalia Mov10 34
  • 87.8 (n)
oppossum
(Monodelphis domestica)
Mammalia MOV10 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOV10 34 35
  • 58.69 (n)
lizard
(Anolis carolinensis)
Reptilia MOV10 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mov10 34
  • 54.43 (n)
zebrafish
(Danio rerio)
Actinopterygii mov10a 35
  • 44 (a)
OneToMany
mov10b.1 35
  • 43 (a)
OneToMany
mov10b.2 35
  • 43 (a)
OneToMany
Dr.12042 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12854 34
fruit fly
(Drosophila melanogaster)
Insecta CG6967 36 35
  • 37 (a)
CG11513 36
  • 33 (a)
CG6701 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM7 35
  • 17 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SDE3 34
  • 48.01 (n)
rice
(Oryza sativa)
Liliopsida Os03g0160400 34
  • 49.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToOne
Species where no ortholog for MOV10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOV10 Gene

ENSEMBL:
Gene Tree for MOV10 (if available)
TreeFam:
Gene Tree for MOV10 (if available)

Paralogs for MOV10 Gene

Paralogs for MOV10 Gene

(1) SIMAP similar genes for MOV10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MOV10: view

Variants for MOV10 Gene

Sequence variations from dbSNP and Humsavar for MOV10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000004804 -- 112,687,856(+) GGTGA(G/T)GTCAA intron-variant
rs1000016671 -- 112,692,915(+) CCAGG(C/T)TGCTC nc-transcript-variant, reference, synonymous-codon
rs1000114216 -- 112,701,137(+) TGGAG(C/T)CTGTA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000126367 -- 112,684,181(+) AAACT(C/G)CTGGG intron-variant
rs1000299807 -- 112,672,644(+) CATGG(A/G)ATGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MOV10 Gene

Variant ID Type Subtype PubMed ID
esv27061 CNV gain+loss 19812545
esv3587217 CNV loss 21293372
esv997362 CNV deletion 20482838
nsv1133888 CNV deletion 24896259

Variation tolerance for MOV10 Gene

Residual Variation Intolerance Score: 7.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOV10 Gene

Human Gene Mutation Database (HGMD)
MOV10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOV10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOV10 Gene

Disorders for MOV10 Gene

Relevant External Links for MOV10

Genetic Association Database (GAD)
MOV10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOV10

No disorders were found for MOV10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOV10 Gene

Publications for MOV10 Gene

  1. APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10. (PMID: 22791714) Liu C. … Zhang H. (J. Biol. Chem. 2012) 3 4 64
  2. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain L.V. … van Duijn C.M. (Nat. Genet. 2011) 3 46 64
  3. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PMID: 21909115) . … Johnson T. (Nature 2011) 3 46 64
  4. Capped small RNAs and MOV10 in human hepatitis delta virus replication. (PMID: 18552826) Haussecker D. … Kay M.A. (Nat. Struct. Mol. Biol. 2008) 3 4 64
  5. MicroRNA silencing through RISC recruitment of eIF6. (PMID: 17507929) Chendrimada T.P. … Shiekhattar R. (Nature 2007) 3 4 64

Products for MOV10 Gene

Sources for MOV10 Gene

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