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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MOV10 Gene

protein-coding   GIFtS: 55
GCID: GC01P113215

Mov10, Moloney leukemia virus 10, homolog (mouse)

(Previous names: Mov10 (Moloney leukemia virus 10, mouse) homolog )
 Explore 2 diseases affiliated with
MOV10 via our new
 Human Malady Compendium 
Biological research products
for MOV10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mov10, Moloney Leukemia Virus 10, Homolog (Mouse)1 2     Mov10 (Moloney Leukemia Virus 10, Mouse) Homolog1
FSAP1131     Functional Spliceosome-Associated Protein 1132
Gb1101     Putative Helicase MOV-102
Moloney Leukemia Virus 10 Protein2 3     EC 3.6.4.133
KIAA16313 5     EC 3.6.18
MGC29481     

External Ids:    HGNC: 72001   Entrez Gene: 43432   Ensembl: ENSG000001553637   OMIM: 6107425   UniProtKB: Q9HCE13   

Export aliases for MOV10 gene to outside databases

Previous GC identifers: GC01P113631 GC01P112101 GC01P112319 GC01P112516 GC01P112929 GC01P113018 GC01P111075


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MOV10_HUMAN, Q9HCE1
Function: Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC).
Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC.
Also required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with
small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA
transcription

Gene Wiki entry for MOV10


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MOV10 gene promoter:
         COUP-TF1   COUP   Lmo2   HNF-4alpha2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   HNF-4alpha1   COUP-TF   Zic1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOV10 promoter sequence
   Search SABiosciences Chromatin IP Primers for MOV10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOV10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

MOV10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOV10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P113215:  view genomic region     (about GC identifiers)

Start:
113,215,763 bp from pter      End:
113,243,368 bp from pter
Size:
27,606 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MOV10_HUMAN, Q9HCE1 (See protein sequence)
Recommended Name: Putative helicase MOV-10  
Size: 1003 amino acids; 113671 Da
Subunit: Interacts with DICER1, EIF2C1/AGO1, EIF2C2/AGO2, EIF6 and TARBP2. Associates with the 60S ribosome. Interacts
with the human hepatitis delta virus (HDV) antigen HDAg. Interacts with APOBEC3G in an RNA-dependent manner
Subcellular location: Cytoplasm, P-body
Sequence caution: Sequence=BAB13457.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAB85000.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q5JR03 Q8TEF0 Q9BSY3 Q9BUJ9
Alternative splicing: 3 isoforms:  Q9HCE1-1   Q9HCE1-2   Q9HCE1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MOV10: NX_Q9HCE1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HCE1

  • 4/7 DME Specific Peptides for MOV10 (Q9HCE1) (see all 7)
     PIIFHGV  QFITKLL  LGFLKNPKR  GPPGTGKTV 

    MOV10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123551.1  NP_066014.1  

    ENSEMBL proteins: 
     ENSP00000399797   ENSP00000358659   ENSP00000358658   ENSP00000350028   ENSP00000439533  
    Reactome Protein details: Q9HCE1
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: MOV10
    OriGene Protein Over-expression Lysate (see all 2): MOV10
    OriGene Custom Protein Services for MOV10 
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    Novus Biologicals MOV10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MOV10

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA16289642
    GO:0005829cytosol TAS--


    MOV10 for ontologies           About GeneDecksing



    MOV10 Antibody Products: 
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    Uscn Antibodies for MOV10
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    Uscn ELISAs and CLIAs for MOV10


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MOV10 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026122 MOV-10/Armitage

    Graphical View of Domain Structure for InterPro Entry Q9HCE1

    ProtoNet protein and cluster: Q9HCE1

    UniProtKB/Swiss-Prot: MOV10_HUMAN, Q9HCE1
    Similarity: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MOV10_HUMAN, Q9HCE1
    Function: Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC).
    Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC.
    Also required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with
    small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA
    transcription
    Catalytic activity: ATP + H(2)O = ADP + phosphate

    Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

    miRNA
    Products:
        
    miRTarBase miRNAs that target MOV10:
    hsa-mir-1 (MIRT001356)

    OriGene 3'-UTR Clone (see all 2): MOV10
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOV10
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate MOV10:
    hsa-miR-374b* hsa-miR-30c hsa-miR-30d hsa-miR-646 hsa-miR-153 hsa-miR-30a hsa-miR-30b hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidMOV10 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MOV10 (see all 7)
    OriGene shRNA RFP: MOV10
    OriGene siRNA: MOV10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOV10

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    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MOV10 (NM_020963)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOV10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOV10 

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    Search LifeMap BioReagents cell lines for MOV10

    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOV10

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0004386helicase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    MOV10 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    Signaling by FGFR1.00
    DAP12 signaling0.83
    Downstream signaling of activated FGFR0.92
    Signaling by EGFR in Cancer0.83
    Signaling by FGFR in disease0.91
    DAP12 interactions0.76
    Signaling by ERBB20.89
    Signaling by PDGF0.72
    2PIP3 activates AKT signaling
    8/9 pathways (see all 9)
    PIP3 activates AKT signaling1.00
    PI3K/AKT activation0.97
    PI3K/AKT Signaling in Cancer1.00
    GAB1 signalosome0.96
    PI3K events in ERBB2 signaling1.00
    Signaling by SCF-KIT0.72
    PI3K events in ERBB4 signaling1.00
    Signaling by ERBB40.67
    3Immune System
    Immune System1.00
    Innate Immune System0.46
    Adaptive Immune System0.59
    4Signaling by the B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)1.00
    Downstream Signaling Events Of B Cell Receptor (BCR)0.81
    5p53 positively regulates transcription of MIR34 microRNAs
    p53 positively regulates transcription of MIR34 microRNAs1.00
    Pre-NOTCH Transcription and Translation0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/32        Reactome Pathways for MOV10 (see all 32)
        Signaling by EGFR in Cancer
    Downstream signal transduction
    Signal Transduction
    Signaling by PDGF
    Downstream Signaling Events Of B Cell Receptor (BCR)



    MOV10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOV10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/372 Interacting proteins for MOV10 (Q9HCE11, 2, 3 ENSP000003500284) via UniProtKB, MINT, STRING, and/or I2D (see all 372)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF2AK2P195251, 3, ENSP000002330574EBI-1055820,EBI-640775 I2D: score=1 STRING: ENSP00000233057
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    PUF60Q9UHX13, ENSP000003220164I2D: score=2 STRING: ENSP00000322016
    ATG12O948173, ENSP000002744594I2D: score=1 STRING: ENSP00000274459
    TRIM71Q2Q1W23, ENSP000003732724I2D: score=1 STRING: ENSP00000373272
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007219Notch signaling pathway TAS--
    GO:0035279mRNA cleavage involved in gene silencing by miRNA IDA16289642


    MOV10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MOV10
    Search CenterWatch for drugs/clinical trials and news about MOV10 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MOV10 gene (2 alternative transcripts): 
    NM_001130079.1  NM_020963.3  

    Unigene Cluster for MOV10:

    Mov10, Moloney leukemia virus 10, homolog (mouse)
    Hs.514941  [show with all ESTs]
    Unigene Representative Sequence: AK074174
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000486416 ENST00000413052(uc001ecl.2 uc001eck.3 uc001ecn.3)
    ENST00000369645 ENST00000461226 ENST00000369644(uc009wgj.1 uc001ecm.3)
    ENST00000496577 ENST00000475429 ENST00000468624 ENST00000465579 ENST00000357443
    ENST00000479858 ENST00000488160 ENST00000482545 ENST00000471160 ENST00000481711
    ENST00000490413 ENST00000495374 ENST00000494319

    miRNA
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    OriGene 3'-UTR Clone (see all 2): MOV10
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOV10
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate MOV10:
    hsa-miR-374b* hsa-miR-30c hsa-miR-30d hsa-miR-646 hsa-miR-153 hsa-miR-30a hsa-miR-30b hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidMOV10 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MOV10 (see all 7)
    OriGene shRNA RFP: MOV10
    OriGene siRNA: MOV10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOV10
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MOV10 (see all 6)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MOV10 (NM_020963)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOV10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOV10 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOV10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOV10

    Additional cDNA sequence: 

    AB046851.1 AK023297.1 AK057353.1 AK074174.1 AK226011.1 AK301229.1 AK308874.1 AK310512.1 
    AL832805.1 AL833353.1 BC002548.1 BC004499.2 BC009312.2 BC025339.1 BX647787.1 

    24/35 DOTS entries (see all 35):

    DT.100838983  DT.92444449  DT.100838980  DT.100767939  DT.95170188  DT.121433300  DT.100764956  DT.101985078 
    DT.92444444  DT.95170190  DT.95128605  DT.102843407  DT.95140367  DT.121433250  DT.100838984  DT.121433259 
    DT.100838978  DT.97765491  DT.92444447  DT.100717851  DT.121433184  DT.100838977  DT.100838979  DT.101977052 

    24/363 AceView cDNA sequences (see all 363):

    BQ212344 BU171199 AU280096 CF272383 AB046851 CF264906 NM_020963 AA436894 
    AI160307 CF264932 BQ884140 BQ017855 BQ877555 BG250549 AI648587 BU163570 
    BE543595 BC002548 BE275156 BC004499 BC025339 AL704964 BE277773 BM457463 

    GeneLoc Exon Structure

    5/25 Alternative Splicing Database (ASD) splice patterns (SP) for MOV10 (see all 25)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ·
    SP1:                                -                                   -     -     -     -     -     -     -     -                                             
    SP2:                                                                    -     -     -     -                                                                     
    SP3:                                                                    -     -     -     -                                                                     
    SP4:                                                                    -     -     -     -     -     -     -     -                                             
    SP5:                                                                                                                                                            

    ExUns: 11e ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c ^ 25a · 25b · 25c · 25d ^ 26a ·
    SP1:                                      -                                                                                         -           -     -     -   
    SP2:                                      -                                                                                         -           -     -     -   
    SP3:                                      -                                                                                                     -     -     -   
    SP4:                                      -                                                                                                                     
    SP5:                                                                                                                                -           -     -     -   

    ExUns: 26b ^ 27a · 27b ^ 28 ^ 29a · 29b
    SP1:              -                     
    SP2:              -                     
    SP3:              -                     
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for MOV10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MOV10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTACCTCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MOV10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MOV10

    SOURCE GeneReport for Unigene cluster: Hs.514941
        SABiosciences Expression via Pathway-Focused PCR Array including MOV10: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MOV10 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MOV101 Mov10, Moloney leukemia virus 10, homolog (mouse) 58.44(n)
    50.65(a)
      419872  NM_001012843.1  NP_001012861.1 
    lizard
    (Anolis carolinensis)
    Reptilia MOV106
    --
    47(a)
    1 ↔ 1
    4(128198014-128229538)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.120422 Transcribed sequence with weak similarity to protein more 77.89(n)    57088199 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69673 mRNA catabolism, nonsense-mediated 37(a)
    (best of 3)
      53F5   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SDE31 putative RNA helicase SDE3 47.33(n)
    39.64(a)
      837047  NM_100425.3  NP_172037.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01604001 hypothetical protein 49.33(n)
    43.96(a)
      4331698  NM_001055572.1  NP_001049037.1 


    ENSEMBL Gene Tree for MOV10 (if available)
    TreeFam Gene Tree for MOV10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MOV10 gene
    HELZ2  HELZ22  MOV10L12  IGHMBP22  
    1 SIMAP similar gene for MOV10 using alignment to 2 protein entries:     MOV10_HUMAN (see all proteins):
    MOV10L1

    MOV10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/485 NCBI SNPs in MOV10 are shown (see all 485    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1822365821,2
    --113215203(+) GCCTAC/GTTCCA 2 -- us2k10--------
    rs1449932911,2
    --113215206(+) TAGTTC/GCAGTG 2 -- us2k10--------
    rs1866367591,2
    --113215218(+) CTGTTA/CTCTTT 2 -- us2k10--------
    rs1153340861,2
    --113215325(+) GAATGC/TCAACT 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1162967841,2
    F,--113215337(+) GTGAAT/ATTACA 2 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1491195581,2
    --113215466(+) TGTAGC/TTTAAG 2 -- us2k10--------
    rs1929662561,2
    --113215470(+) GTTTAA/CGTTGA 2 -- us2k10--------
    rs729845321,2
    C,F,--113215507(+) GATAGG/AGTATA 2 -- us2k14Minor allele frequency- A:0.08WA CSA EA 242
    rs1431714631,2
    --113215514(+) TATATA/GTAAAT 2 -- us2k10--------
    rs120306121,2
    C,F,--113215637(+) GCAGCC/TTGTTT 2 -- us2k17Minor allele frequency- T:0.21NA WA EA 366

    HapMap Linkage Disequilibrium report for MOV10 (113215763 - 113243368 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for MOV10
         7 CNVs: 84476 84475 74648 64616 3306 64617 84477
         1 Indel: 74649

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MOV10 for disorders           About GeneDecksing

    OMIM gene information: 610742    OMIM disorders: --

    2 diseases for MOV10:    About MalaCards
    leukemia    hepatitis


    Export disorders for MOV10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MOV10 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with MOV10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10. (PubMed id 22791714)1, 2 Liu C....Zhang H. (2012)
    2. Capped small RNAs and MOV10 in human hepatitis delta virus replication. (PubMed id 18552826)1, 2 Haussecker D.... Kay M.A. (2008)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Identification of novel argonaute-associated proteins. (PubMed id 16289642)1, 2 Meister G....Tuschl T. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Identification of molecular determinants from Moloney leukemia virus 10 homolog (MOV10) protein for virion packaging and anti-HIV-1 ac tivity. (PubMed id 22105071)1 Abudu A....Zheng Y.H. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4343 HGNC: 7200 AceView: MOV10 Ensembl:ENSG00000155363 euGenes: HUgn4343
    ECgene: MOV10 H-InvDB: MOV10

    (According to HUGE)
    About This Section
    HUGE: KIAA1631

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MOV10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MOV10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MOV10 gene:
    Search GeneIP for patents involving MOV10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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