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MOV10 Gene

protein-coding   GIFtS: 56
GCID: GC01P113215

Mov10, Moloney Leukemia Virus 10, Homolog (Mouse)

(Previous names: Mov10 (Moloney leukemia virus 10, mouse) homolog)
  See MOV10-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mov10, Moloney Leukemia Virus 10, Homolog (Mouse)1 2     fSAP1132
Functional Spliceosome-Associated Protein 1131 2     gb1102
Moloney Leukemia Virus 10 Protein2 3     Putative Helicase MOV-102
KIAA16313 5     EC 3.6.4.133
Mov10 (Moloney Leukemia Virus 10, Mouse) Homolog1     EC 3.6.18

External Ids:    HGNC: 72001   Entrez Gene: 43432   Ensembl: ENSG000001553637   OMIM: 6107425   UniProtKB: Q9HCE13   

Export aliases for MOV10 gene to outside databases

Previous GC identifers: GC01P113631 GC01P112101 GC01P112319 GC01P112516 GC01P112929 GC01P113018 GC01P111075


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MOV10 Gene:
MOV10 (Mov10, Moloney leukemia virus 10, homolog (mouse)) is a protein-coding gene. Diseases associated with MOV10 include leukemia. GO annotations related to this gene include RNA binding and helicase activity. An important paralog of this gene is HELZ.

UniProtKB/Swiss-Prot: MOV10_HUMAN, Q9HCE1
Function: Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex
(RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary
mRNAs by RISC. Also required for RNA-directed transcription and replication of the human hepatitis delta virus
(HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation
sites of RNA-dependent HDV RNA transcription

Gene Wiki entry for MOV10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MOV10 gene promoter:
         COUP-TF1   COUP   Lmo2   HNF-4alpha2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   HNF-4alpha1   COUP-TF   Zic1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOV10 promoter sequence
   Search Chromatin IP Primers for MOV10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MOV10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

MOV10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOV10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P113215:  view genomic region     (about GC identifiers)

Start:
113,215,763 bp from pter      End:
113,243,368 bp from pter
Size:
27,606 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MOV10_HUMAN, Q9HCE1 (See protein sequence)
Recommended Name: Putative helicase MOV-10  
Size: 1003 amino acids; 113671 Da
Subunit: Interacts with DICER1, AGO1, AGO2, EIF6 and TARBP2. Associates with the 60S ribosome. Interacts with the
human hepatitis delta virus (HDV) antigen HDAg. Interacts with APOBEC3G in an RNA-dependent manner
Sequence caution: Sequence=BAB13457.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAB85000.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q5JR03 Q8TEF0 Q9BSY3 Q9BUJ9
Alternative splicing: 3 isoforms:  Q9HCE1-1   Q9HCE1-2   Q9HCE1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MOV10: NX_Q9HCE1

Explore proteomics data for MOV10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys109, Lys121, Lys281, Lys489, Lys530, Lys547, Lys602, Lys695, Lys727, Lys846,
                                 Lys858, Lys967
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MOV10 (Q9HCE1) (see all 7)
     PIIFHGV  QFITKLL  LGFLKNPKR  GPPGTGKTV 


    See MOV10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001123551.1  NP_001273001.1  NP_066014.1  

    ENSEMBL proteins: 
     ENSP00000399797   ENSP00000358659   ENSP00000358658   ENSP00000350028   ENSP00000439533  
    Reactome Protein details: Q9HCE1

    MOV10 Human Recombinant Protein Products:

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    Novus Biologicals MOV10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MOV10

     
    Search eBioscience for Proteins for MOV10 

     
    Search antibodies-online for proteins for MOV10 

     
    antibodies-online peptides for MOV10

    MOV10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for MOV10 at Abcam
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    antibodies-online antibodies for MOV10 (18 products) 

    MOV10 Assay Products:

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    Cloud-Clone Corp. ELISAs for MOV10
    Cloud-Clone Corp. CLIAs for MOV10
    Search eBioscience for ELISAs for MOV10 
    antibodies-online kits for MOV10 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR026122 MOV-10

    Graphical View of Domain Structure for InterPro Entry Q9HCE1

    ProtoNet protein and cluster: Q9HCE1

    UniProtKB/Swiss-Prot: MOV10_HUMAN, Q9HCE1
    Similarity: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily


    Find genes that share domains with MOV10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOV10_HUMAN, Q9HCE1
    Function: Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex
    (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary
    mRNAs by RISC. Also required for RNA-directed transcription and replication of the human hepatitis delta virus
    (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation
    sites of RNA-dependent HDV RNA transcription
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0004386helicase activity IEA--
    GO:0005515protein binding IPI16289642
    GO:0005524ATP binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with MOV10           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MOV10

    miRNA
    Products:
        
    miRTarBase miRNAs that target MOV10:
    hsa-let-7b-5p (MIRT052355), hsa-mir-615-3p (MIRT040443), hsa-mir-155-5p (MIRT020999), hsa-mir-124-3p (MIRT023156), hsa-mir-1 (MIRT001356), hsa-mir-16-5p (MIRT032076), hsa-mir-34a-5p (MIRT025576)

    Block miRNA regulation of human, mouse, rat MOV10 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate MOV10:
    hsa-miR-374b* hsa-miR-30c hsa-miR-30d hsa-miR-646 hsa-miR-153 hsa-miR-30a hsa-miR-30b hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidMOV10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MOV10

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): MOV10 (NM_020963)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOV10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOV10
    Addgene plasmids for MOV10 

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    Browse ESI BIO Cell Lines and PureStem Progenitors for MOV10 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOV10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MOV10_HUMAN, Q9HCE1: Cytoplasm, P-body
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA16289642
    GO:0005615extracellular space IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with MOV10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MOV10 About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    2PI-3K cascade
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    GAB1 signalosome0.93
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    PI-3K cascade0.88
    Signaling by ERBB40.66
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    4beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79
    5Downstream Signaling Events Of B Cell Receptor (BCR)
    Downstream Signaling Events Of B Cell Receptor (BCR)0.79
    Signaling by the B Cell Receptor (BCR)0.79


    Find genes that share SuperPaths with MOV10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 Reactome Pathways for MOV10
        Oxidative Stress Induced Senescence
    Pre-NOTCH Transcription and Translation
    Oncogene Induced Senescence
    Ca2+ pathway
    PIP3 activates AKT signaling


        Pathway & Disease-focused RT2 Profiler PCR Array including MOV10: 
              Polycomb & Trithorax Complexes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MOV10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MOV10 (Q9HCE11, 2, 3 ENSP000003500284) via UniProtKB, MINT, STRING, and/or I2D (see all 417)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF2AK2P195251, 3, ENSP000002330574EBI-1055820,EBI-640775 I2D: score=1 STRING: ENSP00000233057
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    PUF60Q9UHX13, ENSP000003220164I2D: score=2 STRING: ENSP00000322016
    ATG12O948173, ENSP000002744594I2D: score=1 STRING: ENSP00000274459
    TRIM71Q2Q1W23, ENSP000003732724I2D: score=1 STRING: ENSP00000373272
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007219Notch signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--

    Find genes that share ontologies with MOV10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MOV10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MOV10 gene (3 alternative transcripts): 
    NM_001130079.2  NM_001286072.1  NM_020963.4  

    Unigene Cluster for MOV10:

    Mov10, Moloney leukemia virus 10, homolog (mouse)
    Hs.514941  [show with all ESTs]
    Unigene Representative Sequence: AK074174
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486416 ENST00000413052(uc001ecl.2 uc001eck.3 uc001ecn.3)
    ENST00000369645 ENST00000369644(uc009wgj.1 uc001ecm.3) ENST00000496577
    ENST00000475429 ENST00000468624 ENST00000465579 ENST00000357443 ENST00000479858
    ENST00000488160 ENST00000482545 ENST00000471160 ENST00000481711 ENST00000490413
    ENST00000495374 ENST00000494319 ENST00000544796
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate MOV10:
    hsa-miR-374b* hsa-miR-30c hsa-miR-30d hsa-miR-646 hsa-miR-153 hsa-miR-30a hsa-miR-30b hsa-miR-30e
    SwitchGear 3'UTR luciferase reporter plasmidMOV10 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MOV10
    Predesigned siRNA for gene silencing in human, mouse, rat MOV10
    Clone
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    OriGene clones in human, mouse for MOV10 (see all 13)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MOV10 (NM_020963)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOV10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOV10
    Addgene plasmids for MOV10 
    Primer
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    OriGene qPCR primer pairs and template standards for MOV10
    OriGene qSTAR qPCR primer pairs in human, mouse for MOV10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MOV10
      QuantiTect SYBR Green Assays in human, mouse, rat MOV10
      QuantiFast Probe-based Assays in human, mouse, rat MOV10

    Additional mRNA sequence: 

    AB046851.1 AK023297.1 AK057353.1 AK074174.1 AK226011.1 AK301229.1 AK308874.1 AK310512.1 
    AL832805.1 AL833353.1 BC002548.1 BC004499.2 BC009312.2 BC025339.1 BX647787.1 

    Selected DOTS entries (see all 35):

    DT.100838983  DT.92444449  DT.100838980  DT.100767939  DT.95170188  DT.121433300  DT.100764956  DT.101985078 
    DT.92444444  DT.95170190  DT.95128605  DT.102843407  DT.95140367  DT.121433250  DT.100838984  DT.121433259 
    DT.100838978  DT.97765491  DT.92444447  DT.100717851  DT.121433184  DT.100838977  DT.100838979  DT.101977052 

    Selected AceView cDNA sequences (see all 363):

    AU280096 CB158059 CD245610 AI151277 BC002548 BC004499 CF264989 BU616359 
    BE543595 BC009312 CF272383 BF970702 AU134433 AA436894 CF264932 BC025339 
    CB216752 BU631169 CO248446 CF264803 AI160307 BX370258 AK057353 BU902888 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MOV10 (see all 25)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ·
    SP1:                                -                                   -     -     -     -     -     -     -     -                                             
    SP2:                                                                    -     -     -     -                                                                     
    SP3:                                                                    -     -     -     -                                                                     
    SP4:                                                                    -     -     -     -     -     -     -     -                                             
    SP5:                                                                                                                                                            

    ExUns: 11e ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c ^ 25a · 25b · 25c · 25d ^ 26a ·
    SP1:                                      -                                                                                         -           -     -     -   
    SP2:                                      -                                                                                         -           -     -     -   
    SP3:                                      -                                                                                                     -     -     -   
    SP4:                                      -                                                                                                                     
    SP5:                                                                                                                                -           -     -     -   

    ExUns: 26b ^ 27a · 27b ^ 28 ^ 29a · 29b
    SP1:              -                     
    SP2:              -                     
    SP3:              -                     
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for MOV10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MOV10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTACCTCCC
    MOV10 Expression
    About this image

    MOV10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MOV10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514941
        Pathway & Disease-focused RT2 Profiler PCR Array including MOV10: 
              Polycomb & Trithorax Complexes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MOV10 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mov101 , 5 Moloney leukemia virus 101, 5 88.04(n)1
    91.23(a)1
      3 (45.87 cM)5
    174541  NM_001163440.11  NP_001156912.11 
     1047948365 
    chicken
    (Gallus gallus)
    Aves MOV101 Mov10, Moloney leukemia virus 10, homolog (mouse) 58.69(n)
    51.08(a)
      419872  NM_001012843.1  NP_001012861.1 
    lizard
    (Anolis carolinensis)
    Reptilia MOV106
    Mov10, Moloney leukemia virus 10, homolog (mouse)
    47(a)
    1 ↔ 1
    4(128197798-128230220)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mov101 Mov10, Moloney leukemia virus 10, homolog (mouse) 54.43(n)
    51.25(a)
      100491926  XM_002932117.2  XP_002932163.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.120422 Transcribed sequence with weak similarity to protein more 77.89(n)    57088199 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69673 mRNA catabolism, nonsense-mediated 37(a)
    (best of 3)
      53F5   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NAM76
    ATP-dependent RNA helicase of the SFI superfamily ...
    17(a)
    1 → many
    XIII(426712-429627) YMR080C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SDE31 SDE3 48.01(n)
    40.74(a)
      837047  NM_100425.3  NP_172037.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01604001 Os03g0160400 49.24(n)
    43.99(a)
      4331698  NM_001055572.1  NP_001049037.1 


    ENSEMBL Gene Tree for MOV10 (if available)
    TreeFam Gene Tree for MOV10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MOV10 gene
    HELZ2  HELZ22  MOV10L12  UPF12  ZGRF12  
    1 SIMAP similar gene for MOV10 using alignment to 2 protein entries:     MOV10_HUMAN (see all proteins):
    MOV10L1

    Find genes that share paralogs with MOV10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MOV10 (see all 636)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1380143271,2
    Cuntested1113232556(+) GAGTCA/GGGTTC 4 S syn10--------
    rs1822365821,2
    --113215203(+) GCCTAC/GTTCCA 2 -- us2k10--------
    rs1449932911,2
    --113215206(+) TAGTTC/GCAGTG 2 -- us2k10--------
    rs1866367591,2
    --113215218(+) CTGTTA/CTCTTT 2 -- us2k10--------
    rs1153340861,2
    F--113215325(+) GAATGC/TCAACT 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1162967841,2
    C,F--113215337(+) GTGAAT/ATTACA 2 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1491195581,2
    C--113215466(+) TGTAGC/TTTAAG 2 -- us2k10--------
    rs1929662561,2
    --113215470(+) GTTTAA/CGTTGA 2 -- us2k10--------
    rs729845321,2
    C,F--113215507(+) GATAGG/AGTATA 2 -- us2k14Minor allele frequency- A:0.08WA CSA EA 242
    rs1431714631,2
    --113215514(+) TATATA/GTAAAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MOV10 (113215763 - 113243368 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MOV10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv997362CNV Deletion20482838
    esv27061CNV Gain+Loss19812545
    essv21692CNV CNV17122850

    Human Gene Mutation Database (HGMD): MOV10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MOV10
    DNA2.0 Custom Variant and Variant Library Synthesis for MOV10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610742    OMIM disorders: --

    1 disease for MOV10:    
    About MalaCards
    leukemia


    Find genes that share disorders with MOV10           About GenesLikeMe

    Genetic Association Database (GAD): MOV10

    Export disorders for MOV10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MOV10 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with MOV10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10. (PubMed id 22791714)1, 2 Liu C....Zhang H. (J. Biol. Chem. 2012)
    2. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PubMed id 21909115)1, 4  ....Johnson T. (Nature 2011)
    3. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (Nat. Genet. 2011)
    4. Capped small RNAs and MOV10 in human hepatitis delta virus replication. (PubMed id 18552826)1, 2 Haussecker D.... Kay M.A. (Nat. Struct. Mol. Biol. 2008)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. Identification of novel argonaute-associated proteins. (PubMed id 16289642)1, 2 Meister G.... Tuschl T. (Curr. Biol. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Comprehensive proteomic analysis of the human spliceosome. (PubMed id 12226669)1, 3 Zhou Z.... Reed R. (Nature 2002)
    9. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4343 HGNC: 7200 AceView: MOV10 Ensembl:ENSG00000155363 euGenes: HUgn4343
    ECgene: MOV10 H-InvDB: MOV10

    (According to HUGE)
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    HUGE: KIAA1631

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MOV10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MOV10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MOV10 gene:
    Search GeneIP for patents involving MOV10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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