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Aliases for MOV10 Gene

Aliases for MOV10 Gene

  • Mov10 RISC Complex RNA Helicase 2 3
  • Functional Spliceosome-Associated Protein 113 2 3
  • Moloney Leukemia Virus 10 Protein 3 4
  • KIAA1631 4 6
  • Mov10, Moloney Leukemia Virus 10, Homolog (Mouse) 2
  • Mov10 (Moloney Leukemia Virus 10, Mouse) Homolog 2
  • Mov10, Moloney Leukemia Virus 10, Homolog 3
  • Putative Helicase MOV-10 3
  • EC 3.6.4.13 4
  • EC 3.6.1 64
  • FSAP113 3
  • Gb110 3

External Ids for MOV10 Gene

Summaries for MOV10 Gene

GeneCards Summary for MOV10 Gene

MOV10 (Mov10 RISC Complex RNA Helicase) is a Protein Coding gene. Diseases associated with MOV10 include leukemia. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include RNA binding and helicase activity. An important paralog of this gene is UPF1.

UniProtKB/Swiss-Prot for MOV10 Gene

  • Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Also required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.

Gene Wiki entry for MOV10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOV10 Gene

Genomics for MOV10 Gene

Genomic Location for MOV10 Gene

Start:
112,673,141 bp from pter
End:
112,700,753 bp from pter
Size:
27,613 bases
Orientation:
Plus strand

Genomic View for MOV10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MOV10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOV10 Gene

Proteins for MOV10 Gene

  • Protein details for MOV10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCE1-MOV10_HUMAN
    Recommended name:
    Putative helicase MOV-10
    Protein Accession:
    Q9HCE1
    Secondary Accessions:
    • Q5JR03
    • Q8TEF0
    • Q9BSY3
    • Q9BUJ9

    Protein attributes for MOV10 Gene

    Size:
    1003 amino acids
    Molecular mass:
    113671 Da
    Quaternary structure:
    • Interacts with DICER1, AGO1, AGO2, EIF6 and TARBP2. Associates with the 60S ribosome. Interacts with the human hepatitis delta virus (HDV) antigen HDAg. Interacts with APOBEC3G in an RNA-dependent manner.
    SequenceCaution:
    • Sequence=BAB13457.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB85000.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MOV10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOV10 Gene

Proteomics data for MOV10 Gene at MOPED

Selected DME Specific Peptides for MOV10 Gene

Post-translational modifications for MOV10 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys109, Lys121, Lys281, Lys489, Lys530, Lys547, Lys602, Lys695, Lys727, Lys846, Lys858, and Lys967

Other Protein References for MOV10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MOV10 Gene

Protein Domains for MOV10 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MOV10_HUMAN
Family:
  • Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.:
    • Q9HCE1
genes like me logo Genes that share domains with MOV10: view

No data available for Gene Families for MOV10 Gene

Function for MOV10 Gene

Molecular function for MOV10 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Also required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.

Enzyme Numbers (IUBMB) for MOV10 Gene

Gene Ontology (GO) - Molecular Function for MOV10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 16289642
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MOV10: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MOV10 Gene

Localization for MOV10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOV10 Gene

Cytoplasm, P-body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOV10 Gene COMPARTMENTS Subcellular localization image for MOV10 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MOV10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 16289642
GO:0005615 extracellular space IDA 22664934
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MOV10: view

Pathways for MOV10 Gene

genes like me logo Genes that share pathways with MOV10: view

Gene Ontology (GO) - Biological Process for MOV10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007219 Notch signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with MOV10: view

Transcripts for MOV10 Gene

Unigene Clusters for MOV10 Gene

Mov10, Moloney leukemia virus 10, homolog (mouse):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOV10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ·
SP1: - - - - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5:
SP6:
SP7:
SP8: - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - -
SP18: - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - -
SP20:
SP21: - - - - - - -
SP22: - - - - - - -
SP23: -
SP24:
SP25: - - - - - - - - - - -

ExUns: 11e ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c ^ 25a · 25b · 25c · 25d ^ 26a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - - - -
SP6: - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24: -
SP25:

ExUns: 26b ^ 27a · 27b ^ 28 ^ 29a · 29b
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for MOV10 Gene

GeneLoc Exon Structure for
MOV10
ECgene alternative splicing isoforms for
MOV10

Expression for MOV10 Gene

mRNA expression in normal human tissues for MOV10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MOV10 Gene

SOURCE GeneReport for Unigene cluster for MOV10 Gene Hs.514941

genes like me logo Genes that share expressions with MOV10: view

Orthologs for MOV10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOV10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOV10 36
  • 99.53 (n)
  • 100 (a)
MOV10 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MOV10 36
  • 90.33 (n)
  • 92.12 (a)
MOV10 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOV10 36
  • 90.46 (n)
  • 94.82 (a)
MOV10 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mov10 36
  • 88.04 (n)
  • 91.23 (a)
Mov10 16
Mov10 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MOV10 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mov10 36
  • 87.8 (n)
  • 91.63 (a)
chicken
(Gallus gallus)
Aves MOV10 36
  • 58.69 (n)
  • 51.08 (a)
MOV10 37
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MOV10 37
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mov10 36
  • 54.43 (n)
  • 51.25 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12854 36
zebrafish
(Danio rerio)
Actinopterygii Dr.12042 36
mov10a 37
  • 44 (a)
OneToMany
mov10b.1 37
  • 43 (a)
OneToMany
mov10b.2 37
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6967 37
  • 27 (a)
ManyToMany
CG11513 38
  • 33 (a)
CG6967 38
  • 37 (a)
CG6701 38
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM7 37
  • 17 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SDE3 36
  • 48.01 (n)
  • 40.74 (a)
rice
(Oryza sativa)
Liliopsida Os03g0160400 36
  • 49.24 (n)
  • 43.99 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
OneToOne
Species with no ortholog for MOV10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOV10 Gene

ENSEMBL:
Gene Tree for MOV10 (if available)
TreeFam:
Gene Tree for MOV10 (if available)

Paralogs for MOV10 Gene

Paralogs for MOV10 Gene

Selected SIMAP similar genes for MOV10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MOV10: view

Variants for MOV10 Gene

Sequence variations from dbSNP and Humsavar for MOV10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6679 -- 112,700,426(-) TCATG(A/G)CTGTG reference, synonymous-codon, nc-transcript-variant
rs883593 -- 112,694,549(-) CGCCC(C/T)GTCAG reference, synonymous-codon, nc-transcript-variant
rs902288 -- 112,674,807(+) GGCTT(C/T)CCTCC intron-variant
rs902289 -- 112,693,465(+) CCCGC(C/T)GCCCG intron-variant
rs902291 -- 112,693,906(+) TCTTA(A/G)GTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOV10 Gene

Variant ID Type Subtype PubMed ID
esv27061 CNV Gain+Loss 19812545
essv21692 CNV CNV 17122850
esv997362 CNV Deletion 20482838

Relevant External Links for MOV10 Gene

HapMap Linkage Disequilibrium report
MOV10
Human Gene Mutation Database (HGMD)
MOV10

Disorders for MOV10 Gene

(1) MalaCards Diseases for MOV10 Gene

Search for MOV10 Gene in MalaCards »

Relevant External Links for MOV10

Genetic Association Database (GAD)
MOV10
genes like me logo Genes that share disorders with MOV10: view

No data available for UniProtKB/Swiss-Prot for MOV10 Gene

Publications for MOV10 Gene

  1. Capped small RNAs and MOV10 in human hepatitis delta virus replication. (PMID: 18552826) Haussecker D. … Kay M.A. (Nat. Struct. Mol. Biol. 2008) 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Comprehensive proteomic analysis of the human spliceosome. (PMID: 12226669) Zhou Z. … Reed R. (Nature 2002) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of novel argonaute-associated proteins. (PMID: 16289642) Meister G. … Tuschl T. (Curr. Biol. 2005) 3 4

Products for MOV10 Gene

Sources for MOV10 Gene

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