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Aliases for MOV10 Gene

Aliases for MOV10 Gene

  • Mov10 RISC Complex RNA Helicase 2 3 5
  • Functional Spliceosome-Associated Protein 113 2 3
  • Moloney Leukemia Virus 10 Protein 3 4
  • Mov10, Moloney Leukemia Virus 10, Homolog (Mouse) 2
  • Mov10 (Moloney Leukemia Virus 10, Mouse) Homolog 2
  • Mov10, Moloney Leukemia Virus 10, Homolog 3
  • EC 3.6.4.13 4
  • KIAA1631 4
  • EC 3.6.1 63
  • FSAP113 3
  • Gb110 3

External Ids for MOV10 Gene

Previous GeneCards Identifiers for MOV10 Gene

  • GC01P113631
  • GC01P112101
  • GC01P112319
  • GC01P112516
  • GC01P112929
  • GC01P113018
  • GC01P113215
  • GC01P111075

Summaries for MOV10 Gene

GeneCards Summary for MOV10 Gene

MOV10 (Mov10 RISC Complex RNA Helicase) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include poly(A) RNA binding and helicase activity. An important paralog of this gene is UPF1.

UniProtKB/Swiss-Prot for MOV10 Gene

  • Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Also required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.

Gene Wiki entry for MOV10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOV10 Gene

Genomics for MOV10 Gene

Regulatory Elements for MOV10 Gene

Promoters for MOV10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MOV10 on UCSC Golden Path with GeneCards custom track

Genomic Location for MOV10 Gene

Chromosome:
1
Start:
112,673,141 bp from pter
End:
112,700,746 bp from pter
Size:
27,606 bases
Orientation:
Plus strand

Genomic View for MOV10 Gene

Genes around MOV10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOV10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOV10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOV10 Gene

Proteins for MOV10 Gene

  • Protein details for MOV10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCE1-MOV10_HUMAN
    Recommended name:
    Putative helicase MOV-10
    Protein Accession:
    Q9HCE1
    Secondary Accessions:
    • Q5JR03
    • Q8TEF0
    • Q9BSY3
    • Q9BUJ9

    Protein attributes for MOV10 Gene

    Size:
    1003 amino acids
    Molecular mass:
    113671 Da
    Quaternary structure:
    • Interacts with DICER1, AGO1, AGO2, EIF6 and TARBP2. Associates with the 60S ribosome. Interacts with the human hepatitis delta virus (HDV) antigen HDAg. Interacts with APOBEC3G in an RNA-dependent manner.
    SequenceCaution:
    • Sequence=BAB13457.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB85000.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MOV10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOV10 Gene

Proteomics data for MOV10 Gene at MOPED

Selected DME Specific Peptides for MOV10 Gene

Post-translational modifications for MOV10 Gene

  • Ubiquitination at Lys 109, Lys 121, Lys 281, Lys 489, Lys 530, Lys 547, Lys 602, Lys 695, Lys 727, Lys 846, Lys 858, and Lys 967
  • Modification sites at PhosphoSitePlus

Other Protein References for MOV10 Gene

Domains & Families for MOV10 Gene

Gene Families for MOV10 Gene

Protein Domains for MOV10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MOV10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCE1

UniProtKB/Swiss-Prot:

MOV10_HUMAN :
  • Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
Family:
  • Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
genes like me logo Genes that share domains with MOV10: view

Function for MOV10 Gene

Molecular function for MOV10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Also required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.

Enzyme Numbers (IUBMB) for MOV10 Gene

Phenotypes for MOV10 Gene

GenomeRNAi human phenotypes for MOV10:
genes like me logo Genes that share phenotypes with MOV10: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOV10 Gene

Localization for MOV10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOV10 Gene

Cytoplasm, P-body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOV10 Gene COMPARTMENTS Subcellular localization image for MOV10 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MOV10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
genes like me logo Genes that share ontologies with MOV10: view

Pathways & Interactions for MOV10 Gene

genes like me logo Genes that share pathways with MOV10: view

Pathways by source for MOV10 Gene

Gene Ontology (GO) - Biological Process for MOV10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with MOV10: view

No data available for SIGNOR curated interactions for MOV10 Gene

Drugs & Compounds for MOV10 Gene

(1) Drugs for MOV10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for MOV10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with MOV10: view

Transcripts for MOV10 Gene

Unigene Clusters for MOV10 Gene

Mov10, Moloney leukemia virus 10, homolog (mouse):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOV10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ·
SP1: - - - - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5:
SP6:
SP7:
SP8: - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - -
SP18: - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - -
SP20:
SP21: - - - - - - -
SP22: - - - - - - -
SP23: -
SP24:
SP25: - - - - - - - - - - -

ExUns: 11e ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c ^ 25a · 25b · 25c · 25d ^ 26a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - - - -
SP6: - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24: -
SP25:

ExUns: 26b ^ 27a · 27b ^ 28 ^ 29a · 29b
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for MOV10 Gene

GeneLoc Exon Structure for
MOV10
ECgene alternative splicing isoforms for
MOV10

Expression for MOV10 Gene

mRNA expression in normal human tissues for MOV10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MOV10 Gene

This gene is overexpressed in Bone marrow stromal cell (13.5) and Fetal Liver (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MOV10 Gene



SOURCE GeneReport for Unigene cluster for MOV10 Gene Hs.514941

genes like me logo Genes that share expression patterns with MOV10: view

Protein tissue co-expression partners for MOV10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MOV10 Gene

Orthologs for MOV10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOV10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MOV10 35
  • 90.33 (n)
  • 92.12 (a)
MOV10 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOV10 35
  • 90.46 (n)
  • 94.82 (a)
MOV10 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mov10 35
  • 88.04 (n)
  • 91.23 (a)
Mov10 16
Mov10 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MOV10 35
  • 99.53 (n)
  • 100 (a)
MOV10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mov10 35
  • 87.8 (n)
  • 91.63 (a)
oppossum
(Monodelphis domestica)
Mammalia MOV10 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOV10 35
  • 58.69 (n)
  • 51.08 (a)
MOV10 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MOV10 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mov10 35
  • 54.43 (n)
  • 51.25 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12042 35
mov10a 36
  • 44 (a)
OneToMany
mov10b.1 36
  • 43 (a)
OneToMany
mov10b.2 36
  • 43 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12854 35
fruit fly
(Drosophila melanogaster)
Insecta CG11513 37
  • 33 (a)
CG6701 37
  • 33 (a)
CG6967 37
  • 37 (a)
CG6967 36
  • 27 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM7 36
  • 17 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SDE3 35
  • 48.01 (n)
  • 40.74 (a)
rice
(Oryza sativa)
Liliopsida Os03g0160400 35
  • 49.24 (n)
  • 43.99 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for MOV10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOV10 Gene

ENSEMBL:
Gene Tree for MOV10 (if available)
TreeFam:
Gene Tree for MOV10 (if available)

Paralogs for MOV10 Gene

Paralogs for MOV10 Gene

(1) SIMAP similar genes for MOV10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MOV10: view

Variants for MOV10 Gene

Sequence variations from dbSNP and Humsavar for MOV10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6679 -- 112,700,426(-) TCATG(A/G)CTGTG nc-transcript-variant, reference, synonymous-codon
rs883593 -- 112,694,549(-) CGCCC(C/T)GTCAG nc-transcript-variant, reference, synonymous-codon
rs902288 -- 112,674,807(+) GGCTT(C/T)CCTCC intron-variant
rs902289 -- 112,693,465(+) CCCGC(C/T)GCCCG intron-variant
rs902291 -- 112,693,906(+) TCTTA(A/G)GTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOV10 Gene

Variant ID Type Subtype PubMed ID
esv27061 CNV Gain+Loss 19812545
essv21692 CNV CNV 17122850
esv997362 CNV Deletion 20482838

Variation tolerance for MOV10 Gene

Residual Variation Intolerance Score: 7.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOV10 Gene

HapMap Linkage Disequilibrium report
MOV10
Human Gene Mutation Database (HGMD)
MOV10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOV10 Gene

Disorders for MOV10 Gene

Relevant External Links for MOV10

Genetic Association Database (GAD)
MOV10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOV10

No disorders were found for MOV10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOV10 Gene

Publications for MOV10 Gene

  1. APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10. (PMID: 22791714) Liu C. … Zhang H. (J. Biol. Chem. 2012) 3 4 67
  2. Comprehensive proteomic analysis of the human spliceosome. (PMID: 12226669) Zhou Z. … Reed R. (Nature 2002) 2 3
  3. Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. (PMID: 25249183) Lu X. … Gu D. (Hum. Mol. Genet. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MOV10 Gene

Sources for MOV10 Gene

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