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Aliases for MOSPD3 Gene

Aliases for MOSPD3 Gene

  • Motile Sperm Domain Containing 3 2 3 5
  • Motile Sperm Domain-Containing Protein 3 3
  • NET30 3
  • CDS3 3

External Ids for MOSPD3 Gene

Previous GeneCards Identifiers for MOSPD3 Gene

  • GC07P099822
  • GC07P099854
  • GC07P100048
  • GC07P100209
  • GC07P094841

Summaries for MOSPD3 Gene

Entrez Gene Summary for MOSPD3 Gene

  • This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for MOSPD3 Gene

MOSPD3 (Motile Sperm Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is MOSPD1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOSPD3 Gene

Genomics for MOSPD3 Gene

Regulatory Elements for MOSPD3 Gene

Enhancers for MOSPD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F100639 0.9 Ensembl ENCODE 43.2 +29.5 29463 3.2 HDGF PKNOX1 ARNT MLX ARID4B DMAP1 YY1 CBX5 KLF13 ZNF263 MOSPD3 GIGYF1 TFR2
GH07F100626 0.2 ENCODE 27.3 +14.7 14677 0.9 ATF1 PKNOX1 CBX3 ARNT SIN3A NFXL1 FEZF1 GTF3C2 GLIS2 EGR1 MOSPD3 GIGYF1 STAG3L5P ENSG00000242798 PPP1R35 AP4M1 MEPCE TFR2
GH07F100798 0.6 Ensembl ENCODE 23.9 +192.0 192045 10.7 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZNF143 GIGYF1 STAG3L5P MOSPD3 EPHB4 RN7SL750P RN7SL416P PCOLCE ENSG00000242798 PPP1R35 ACHE
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MOSPD3 on UCSC Golden Path with GeneCards custom track

Promoters for MOSPD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001048960 298 2001 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF143 FOS KLF13

Genomic Location for MOSPD3 Gene

100,612,102 bp from pter
100,615,384 bp from pter
3,283 bases
Plus strand

Genomic View for MOSPD3 Gene

Genes around MOSPD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOSPD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOSPD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOSPD3 Gene

Proteins for MOSPD3 Gene

  • Protein details for MOSPD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Motile sperm domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • A4D2D1
    • A6NG17
    • C9JE89
    • D6W5W1
    • O75423
    • O75424

    Protein attributes for MOSPD3 Gene

    235 amino acids
    Molecular mass:
    25519 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MOSPD3 Gene


neXtProt entry for MOSPD3 Gene

Post-translational modifications for MOSPD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MOSPD3 Gene

Domains & Families for MOSPD3 Gene

Protein Domains for MOSPD3 Gene

Suggested Antigen Peptide Sequences for MOSPD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MSP domain.
  • Contains 1 MSP domain.
genes like me logo Genes that share domains with MOSPD3: view

No data available for Gene Families for MOSPD3 Gene

Function for MOSPD3 Gene

Phenotypes for MOSPD3 Gene

genes like me logo Genes that share phenotypes with MOSPD3: view

Animal Model Products

miRNA for MOSPD3 Gene

miRTarBase miRNAs that target MOSPD3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOSPD3 Gene

Localization for MOSPD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOSPD3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MOSPD3 Gene COMPARTMENTS Subcellular localization image for MOSPD3 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 3
nucleus 2
plasma membrane 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MOSPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MOSPD3: view

Pathways & Interactions for MOSPD3 Gene

SuperPathways for MOSPD3 Gene

No Data Available

Interacting Proteins for MOSPD3 Gene

Gene Ontology (GO) - Biological Process for MOSPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007507 heart development IEA --
genes like me logo Genes that share ontologies with MOSPD3: view

No data available for Pathways by source and SIGNOR curated interactions for MOSPD3 Gene

Transcripts for MOSPD3 Gene

Unigene Clusters for MOSPD3 Gene

Motile sperm domain containing 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOSPD3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP1: - - -
SP2: - -
SP4: -
SP5: - - - -

Relevant External Links for MOSPD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MOSPD3 Gene

mRNA expression in normal human tissues for MOSPD3 Gene

Protein differential expression in normal tissues from HIPED for MOSPD3 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MOSPD3 Gene

Protein tissue co-expression partners for MOSPD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOSPD3 Gene:


SOURCE GeneReport for Unigene cluster for MOSPD3 Gene:

genes like me logo Genes that share expression patterns with MOSPD3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MOSPD3 Gene

Orthologs for MOSPD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MOSPD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MOSPD3 34 35
  • 99.43 (n)
(Canis familiaris)
Mammalia MOSPD3 34 35
  • 91.31 (n)
(Bos Taurus)
Mammalia MOSPD3 34 35
  • 89.5 (n)
(Mus musculus)
Mammalia Mospd3 34 16 35
  • 87.38 (n)
(Rattus norvegicus)
Mammalia Mospd3 34
  • 86.1 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mospd3 34
  • 54.26 (n)
(Caenorhabditis elegans)
Secernentea C34D10.1 35
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
Species where no ortholog for MOSPD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MOSPD3 Gene

Gene Tree for MOSPD3 (if available)
Gene Tree for MOSPD3 (if available)

Paralogs for MOSPD3 Gene

Paralogs for MOSPD3 Gene

(1) SIMAP similar genes for MOSPD3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MOSPD3: view

Variants for MOSPD3 Gene

Sequence variations from dbSNP and Humsavar for MOSPD3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1053507 -- 100,612,945(+) GACCC(C/T)GACAG reference, stop-gained
rs112318502 -- 100,613,614(+) AGCGT(A/G)CCCCC reference, missense
rs112326245 -- 100,614,146(+) GGACA(C/T)TTGCA intron-variant
rs114160855 -- 100,611,238(+) CCCAT(A/G)GAAAA upstream-variant-2KB
rs115012419 -- 100,610,974(+) CTCCA(C/T)TGCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MOSPD3 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv5868 CNV deletion 18451855
nsv831072 CNV loss 17160897
nsv951386 CNV deletion 24416366

Variation tolerance for MOSPD3 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOSPD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOSPD3 Gene

Disorders for MOSPD3 Gene

Relevant External Links for MOSPD3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MOSPD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOSPD3 Gene

Publications for MOSPD3 Gene

  1. A novel transmembrane MSP-containing protein that plays a role in right ventricle development. (PMID: 15533722) Pall G.S. … Forrester L.M. (Genomics 2004) 2 3 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  4. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Gloeckner G. … Rosenthal A. (Genome Res. 1998) 3 4 64
  5. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PMID: 19862010) Ganesh S.K. … Lin J.P. (Nat. Genet. 2009) 46 64

Products for MOSPD3 Gene

Sources for MOSPD3 Gene

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