MOSPD3 Gene
protein-coding GIFtS: 45
GCID: GC07P100209
|
|
motile sperm domain containing 3
| |
Aliases
for MOSPD3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Motile Sperm Domain Containing 31 2 | | CDS31 2 | | NET301 2 | | Motile Sperm Domain-Containing Protein 32 |
Export aliases for MOSPD3 gene to outside databasesPrevious GC identifers: GC07P099822 GC07P099854 GC07P100048 GC07P094841 |
Summaries
for MOSPD3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MOSPD3:
This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similarmouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splicevariants, encoding different isoforms, have been described. (provided by RefSeq, Jul 2008)
|
Genomic Views
for MOSPD3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MOSPD3 gene promoter:
PPAR-gamma1 Sp1 Nkx2-5 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MOSPD3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOSPD3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22MOSPD3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P100209: view genomic region
(about GC identifiers)
Start:
|
100,209,725 bp from pter |
End:
|
100,213,007 bp from pter |
Size:
|
3,283 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 99,569,356-99,572,631 |
|
Proteins
for MOSPD3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MSPD3_HUMAN, O75425 (See
protein sequence)Recommended Name: Motile sperm domain-containing protein 3 Size: 235 amino acids; 25519 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A4D2D1 A6NG17 C9JE89 D6W5W1 O75423 O75424Alternative splicing: 4 isoforms: O75425-1 O75425-2 O75425-3 O75425-4 (Gene prediction confirmed by EST data)Explore the universe of human proteins at neXtProt for MOSPD3: NX_O75425
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75425
MOSPD3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001035186.1 NP_001035187.1 NP_001035188.1 NP_076438.1
ENSEMBL proteins: ENSP00000223054 ENSP00000419535 ENSP00000417276 ENSP00000377522 ENSP00000404626 ENSP00000368842
Human Recombinant Protein Products for MOSPD3:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
MOSPD3 for ontologies About GeneDecksing
MOSPD3 Antibody Products:
Assay Products for MOSPD3: |
Protein
Domains /
Families
for MOSPD3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MOSPD3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75425ProtoNet protein and cluster: O75425 1 Blocks protein family: IPB000535 Major sperm protein (MSP) domain
UniProtKB/Swiss-Prot: MSPD3_HUMAN, O75425Similarity: Contains 1 MSP domain |
Function
for MOSPD3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- | | GO:0005515 | protein binding |
-- | -- |
MOSPD3 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for MOSPD3:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mospd3):
MOSPD3 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MOSPD3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MOSPD3 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): MOSPD3 (NM_001040099) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MOSPD3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOSPD3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOSPD3 |
|
Pathways & Interactions
for MOSPD3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOSPD3
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007507 | heart development |
IEA | -- |
MOSPD3 for ontologies About GeneDecksing
|
Drugs & Compounds
for MOSPD3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MOSPD3
Search CenterWatch for drugs/clinical trials and news about MOSPD3 / MSPD3
|
Transcripts
for MOSPD3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MOSPD3 gene (4 alternative transcripts): NM_001040097.1 NM_001040098.1 NM_001040099.1 NM_023948.4 Unigene Cluster for MOSPD3: Motile sperm domain containing 3 Hs.521086 [show with all ESTs]Unigene Representative Sequence: BQ8883598 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000223054(uc003uvq.3) ENST00000462372 ENST00000490309 ENST00000493970
ENST00000393950(uc003uvs.3 uc003uvt.3) ENST00000424091 ENST00000497456
ENST00000379527(uc003uvr.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MOSPD3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MOSPD3 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): MOSPD3 (NM_001040099) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MOSPD3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOSPD3 |
Additional cDNA sequence: BC005042.1 BC009482.2 BC011653.2 BC028475.2 11 DOTS entries: DT.446249 DT.95370373 DT.100783973 DT.87045978 DT.95334348 DT.75163361 DT.100783976 DT.95370365 DT.95370374 DT.95370375 DT.97843103 24/118 AceView cDNA sequences (see all 118): BM835965 BC011653 BM928264 BU622401 AI685699 AI964021 BI836298 NM_023948 AI348189 BM715809 BX394921 CD671269 AW016106 AI423758 BQ636883 AI080077 AA765993 BQ576200 BC005042 AI268910 AI424097 AI422074 AI087203 BE857105
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MOSPD3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 |
|---|
|
| SP1: | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MOSPD3
|
Expression
for MOSPD3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MOSPD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTTCCTCC
About this image
See MOSPD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MOSPD3
SOURCE GeneReport for Unigene cluster: Hs.521086
SABiosciences Custom PCR Arrays for MOSPD3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MOSPD3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MOSPD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOSPD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOSPD3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOSPD3 |
Orthologs
for MOSPD3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MOSPD3 gene from 2/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
30(a) |
1 → many |
Group4.19(121760-123179) |
worm
(Caenorhabditis elegans) |
Secernentea |
C34D10.16 |
Protein C34D10.1 |
28(a) |
1 → many |
X(8029429-8031502) |
ENSEMBL Gene Tree for MOSPD3 (if available)
TreeFam Gene Tree for MOSPD3 (if available) |
Paralogs
for MOSPD3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MOSPD3 gene
- MOSPD12
1 SIMAP similar gene for MOSPD3 using alignment to 3 protein entries: MSPD3_HUMAN (see all proteins):MOSPD1
MOSPD3 for paralogs About GeneDecksing
|
Genomic Variants
for MOSPD3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MOSPD3 (100209725 - 100213007 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MOSPD3
1 CNV: 4550 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MOSPD3 |
|
Disorders
/ Diseases
for MOSPD3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MOSPD3 for disorders About MalaCards
MOSPD3 for disorders About GeneDecksing
OMIM gene information: 609125
OMIM disorders: --
Export disorders for MOSPD3 gene to outside databases
|
Publications
for MOSPD3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MOSPD3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MOSPD3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel transmembrane MSP-containing protein that plays a role in right ventricle development. (PubMed id 15533722)1, 3, 9 Pall G.S....Forrester L.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PubMed id 9799793)1, 2 Gloeckner G.... Rosenthal A. (1998)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MOSPD3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MOSPD3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MOSPD3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MOSPD3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MOSPD3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MOSPD3 gene:
Search GeneIP for patents involving MOSPD3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MOSPD3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MOSPD3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MOSPD3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MOSPD3 | | | OriGene Protein Over-expression Lysate for MOSPD3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MOSPD3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MOSPD3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MOSPD3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MOSPD3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MOSPD3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MOSPD3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOSPD3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOSPD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOSPD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOSPD3 |
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 | | | MOSPD3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOSPD3 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for MOSPD3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOSPD3 |
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