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Aliases for MOSPD3 Gene

Aliases for MOSPD3 Gene

  • Motile Sperm Domain Containing 3 2 3 5
  • NET30 3
  • CDS3 3

External Ids for MOSPD3 Gene

Previous GeneCards Identifiers for MOSPD3 Gene

  • GC07P099822
  • GC07P099854
  • GC07P100048
  • GC07P100209
  • GC07P094841

Summaries for MOSPD3 Gene

Entrez Gene Summary for MOSPD3 Gene

  • This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for MOSPD3 Gene

MOSPD3 (Motile Sperm Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is MOSPD1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOSPD3 Gene

Genomics for MOSPD3 Gene

Regulatory Elements for MOSPD3 Gene

Enhancers for MOSPD3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MOSPD3 on UCSC Golden Path with GeneCards custom track

Promoters for MOSPD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MOSPD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MOSPD3 Gene

100,612,102 bp from pter
100,615,384 bp from pter
3,283 bases
Plus strand

Genomic View for MOSPD3 Gene

Genes around MOSPD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOSPD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOSPD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOSPD3 Gene

Proteins for MOSPD3 Gene

  • Protein details for MOSPD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Motile sperm domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • A4D2D1
    • A6NG17
    • C9JE89
    • D6W5W1
    • O75423
    • O75424

    Protein attributes for MOSPD3 Gene

    235 amino acids
    Molecular mass:
    25519 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MOSPD3 Gene


neXtProt entry for MOSPD3 Gene

Proteomics data for MOSPD3 Gene at MOPED

Post-translational modifications for MOSPD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MOSPD3 Gene

Domains & Families for MOSPD3 Gene

Protein Domains for MOSPD3 Gene

Suggested Antigen Peptide Sequences for MOSPD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MSP domain.
  • Contains 1 MSP domain.
genes like me logo Genes that share domains with MOSPD3: view

No data available for Gene Families for MOSPD3 Gene

Function for MOSPD3 Gene

Phenotypes for MOSPD3 Gene

genes like me logo Genes that share phenotypes with MOSPD3: view

Animal Model Products

miRNA for MOSPD3 Gene

miRTarBase miRNAs that target MOSPD3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOSPD3 Gene

Localization for MOSPD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOSPD3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MOSPD3 Gene COMPARTMENTS Subcellular localization image for MOSPD3 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 3
nucleus 2
plasma membrane 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MOSPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MOSPD3: view

Pathways & Interactions for MOSPD3 Gene

SuperPathways for MOSPD3 Gene

No Data Available

Interacting Proteins for MOSPD3 Gene

Gene Ontology (GO) - Biological Process for MOSPD3 Gene


No data available for Pathways by source and SIGNOR curated interactions for MOSPD3 Gene

Drugs & Compounds for MOSPD3 Gene

No Compound Related Data Available

Transcripts for MOSPD3 Gene

Unigene Clusters for MOSPD3 Gene

Motile sperm domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOSPD3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP1: - - -
SP2: - -
SP4: -
SP5: - - - -

Relevant External Links for MOSPD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MOSPD3 Gene

mRNA expression in normal human tissues for MOSPD3 Gene

Protein differential expression in normal tissues from HIPED for MOSPD3 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MOSPD3 Gene

SOURCE GeneReport for Unigene cluster for MOSPD3 Gene Hs.521086

genes like me logo Genes that share expression patterns with MOSPD3: view

Protein tissue co-expression partners for MOSPD3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MOSPD3 Gene

Orthologs for MOSPD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MOSPD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MOSPD3 35
  • 89.5 (n)
  • 87.66 (a)
  • 88 (a)
(Canis familiaris)
Mammalia MOSPD3 35
  • 91.31 (n)
  • 91.88 (a)
  • 92 (a)
(Mus musculus)
Mammalia Mospd3 35
  • 87.38 (n)
  • 88.51 (a)
Mospd3 16
Mospd3 36
  • 89 (a)
(Pan troglodytes)
Mammalia MOSPD3 35
  • 99.43 (n)
  • 98.3 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Mospd3 35
  • 86.1 (n)
  • 89.36 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mospd3 35
  • 54.26 (n)
  • 48.4 (a)
(Caenorhabditis elegans)
Secernentea C34D10.1 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
Species with no ortholog for MOSPD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MOSPD3 Gene

Gene Tree for MOSPD3 (if available)
Gene Tree for MOSPD3 (if available)

Paralogs for MOSPD3 Gene

Paralogs for MOSPD3 Gene

(1) SIMAP similar genes for MOSPD3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MOSPD3: view

Variants for MOSPD3 Gene

Sequence variations from dbSNP and Humsavar for MOSPD3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1053507 -- 100,612,945(+) GACCC(C/T)GACAG reference, stop-gained
rs6969584 -- 100,612,124(+) GCAGA(A/C)ACAAA upstream-variant-2KB, utr-variant-5-prime
rs6969697 -- 100,611,981(+) ACCCC(A/G)CCCCC upstream-variant-2KB
rs13224788 -- 100,612,353(+) GGCGG(A/C)GTCAC intron-variant, upstream-variant-2KB
rs13224797 -- 100,612,367(+) TCGCT(C/T)TGCAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MOSPD3 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
dgv7398n71 CNV Loss 21882294
nsv888779 CNV Loss 21882294
dgv7399n71 CNV Loss 21882294
nsv831072 CNV Loss 17160897
nsv5868 CNV Loss 18451855
nsv888790 CNV Gain 21882294

Variation tolerance for MOSPD3 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MOSPD3 Gene

Disorders for MOSPD3 Gene

Relevant External Links for MOSPD3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MOSPD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOSPD3 Gene

Publications for MOSPD3 Gene

  1. A novel transmembrane MSP-containing protein that plays a role in right ventricle development. (PMID: 15533722) Pall G.S. … Forrester L.M. (Genomics 2004) 2 3 23 67
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Gloeckner G. … Rosenthal A. (Genome Res. 1998) 3

Products for MOSPD3 Gene

Sources for MOSPD3 Gene