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Aliases for MOSPD2 Gene

Aliases for MOSPD2 Gene

  • Motile Sperm Domain Containing 2 2 3 5

External Ids for MOSPD2 Gene

Previous GeneCards Identifiers for MOSPD2 Gene

  • GC0XP014253
  • GC0XP014651
  • GC0XP014801
  • GC0XP012649

Summaries for MOSPD2 Gene

GeneCards Summary for MOSPD2 Gene

MOSPD2 (Motile Sperm Domain Containing 2) is a Protein Coding gene. Among its related pathways are Innate Immune System. GO annotations related to this gene include structural molecule activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOSPD2 Gene

Genomics for MOSPD2 Gene

Regulatory Elements for MOSPD2 Gene

Enhancers for MOSPD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG014872 1 ENCODE 45.4 0.0 -24 2.0 HDGF PKNOX1 ATF1 ARID4B E2F7 SIN3A DMAP1 BRCA1 ZNF2 ZNF48 MOSPD2 FANCB
GH0XG014673 1.1 Ensembl ENCODE 27.7 -199.5 -199485 0.8 INSM2 KLF17 RFX5 GATA2 ZNF366 FOS CREM YY2 CEBPB JUNB MOSPD2 PIR55145 PIR53411
GH0XG014851 0.4 Ensembl 51.3 -21.5 -21505 1.0 ZNF664 ZBTB33 MOSPD2 FANCB NPM1P9
GH0XG014963 0.8 Ensembl ENCODE 17.4 +90.6 90572 1.4 CTCF JUND POLR2A SMARCA4 FOS RAD21 MOSPD2 GC0XM014977
GH0XG014899 1 FANTOM5 Ensembl 9.4 +26.5 26496 0.6 JUN NR2F1 JUNB GABPA NR2F2 JUND ATF3 IKZF1 BCL6B FOS MOSPD2 PIGA GC0XM014977
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MOSPD2 on UCSC Golden Path with GeneCards custom track

Promoters for MOSPD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000244713 195 2401 HDGF PKNOX1 ATF1 ARID4B E2F7 SIN3A DMAP1 BRCA1 ZNF2 ZNF48

Transcription factor binding sites by QIAGEN in the MOSPD2 gene promoter:

Genomic Location for MOSPD2 Gene

Chromosome:
X
Start:
14,873,405 bp from pter
End:
14,922,327 bp from pter
Size:
48,923 bases
Orientation:
Plus strand

Genomic View for MOSPD2 Gene

Genes around MOSPD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOSPD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOSPD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOSPD2 Gene

Proteins for MOSPD2 Gene

  • Protein details for MOSPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHP6-MSPD2_HUMAN
    Recommended name:
    Motile sperm domain-containing protein 2
    Protein Accession:
    Q8NHP6
    Secondary Accessions:
    • Q8N3H2
    • Q8NA83

    Protein attributes for MOSPD2 Gene

    Size:
    518 amino acids
    Molecular mass:
    59746 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MOSPD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOSPD2 Gene

Post-translational modifications for MOSPD2 Gene

  • Ubiquitination at posLast=127127
  • Modification sites at PhosphoSitePlus

Other Protein References for MOSPD2 Gene

No data available for DME Specific Peptides for MOSPD2 Gene

Domains & Families for MOSPD2 Gene

Suggested Antigen Peptide Sequences for MOSPD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MOSPD2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MOSPD2 Gene

Function for MOSPD2 Gene

Phenotypes for MOSPD2 Gene

genes like me logo Genes that share phenotypes with MOSPD2: view

Animal Model Products

CRISPR Products

miRNA for MOSPD2 Gene

miRTarBase miRNAs that target MOSPD2

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOSPD2 Gene

Localization for MOSPD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOSPD2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOSPD2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MOSPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
GO:0035579 specific granule membrane TAS --
genes like me logo Genes that share ontologies with MOSPD2: view

Pathways & Interactions for MOSPD2 Gene

genes like me logo Genes that share pathways with MOSPD2: view

Pathways by source for MOSPD2 Gene

3 Reactome pathways for MOSPD2 Gene

Gene Ontology (GO) - Biological Process for MOSPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with MOSPD2: view

No data available for SIGNOR curated interactions for MOSPD2 Gene

Drugs & Compounds for MOSPD2 Gene

No Compound Related Data Available

Transcripts for MOSPD2 Gene

Unigene Clusters for MOSPD2 Gene

Motile sperm domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOSPD2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - -
SP5: -

Relevant External Links for MOSPD2 Gene

GeneLoc Exon Structure for
MOSPD2
ECgene alternative splicing isoforms for
MOSPD2

Expression for MOSPD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOSPD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOSPD2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.9) and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for MOSPD2 Gene

This gene is overexpressed in Bone (22.6) and Spinal cord (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MOSPD2 Gene



NURSA nuclear receptor signaling pathways regulating expression of MOSPD2 Gene:

MOSPD2

SOURCE GeneReport for Unigene cluster for MOSPD2 Gene:

Hs.744919

Evidence on tissue expression from TISSUES for MOSPD2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with MOSPD2: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOSPD2 Gene

Orthologs for MOSPD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOSPD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOSPD2 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia MOSPD2 34 35
  • 92.34 (n)
cow
(Bos Taurus)
Mammalia MOSPD2 34 35
  • 89.68 (n)
-- 35
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mospd2 34 16 35
  • 86.94 (n)
rat
(Rattus norvegicus)
Mammalia Mospd2 34
  • 86.79 (n)
oppossum
(Monodelphis domestica)
Mammalia MOSPD2 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MOSPD2 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOSPD2 34 35
  • 72.42 (n)
lizard
(Anolis carolinensis)
Reptilia MOSPD2 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mospd2 34
  • 67.73 (n)
Str.3865 34
zebrafish
(Danio rerio)
Actinopterygii mospd2 34 35
  • 61.37 (n)
wufc48a06 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9762 34
fruit fly
(Drosophila melanogaster)
Insecta CG33523 34 35
  • 44.99 (n)
CG32407 35
  • 28 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005556 34
  • 44.57 (n)
worm
(Caenorhabditis elegans)
Secernentea hpo-28 34 35
  • 46.03 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CSR1 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
CSA.9460 35
  • 31 (a)
OneToMany
CSA.3857 35
  • 18 (a)
OneToMany
Species where no ortholog for MOSPD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOSPD2 Gene

ENSEMBL:
Gene Tree for MOSPD2 (if available)
TreeFam:
Gene Tree for MOSPD2 (if available)

Paralogs for MOSPD2 Gene

(1) SIMAP similar genes for MOSPD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MOSPD2: view

No data available for Paralogs for MOSPD2 Gene

Variants for MOSPD2 Gene

Sequence variations from dbSNP and Humsavar for MOSPD2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs756766337 Likely benign 14,873,026(+) CGATA(C/T)GGTAT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1057515812 Uncertain significance 14,873,024(-) ACCGT(A/T)TCGAC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs149617434 Benign 14,873,023(+) CGTCG(A/C)TACGG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000451219 -- 14,908,274(+) CAAAA(A/C)AAATT intron-variant
rs1000475809 -- 14,877,598(+) GGCCT(C/T)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOSPD2 Gene

Variant ID Type Subtype PubMed ID
esv3372386 CNV insertion 20981092
nsv9934 CNV loss 18304495

Variation tolerance for MOSPD2 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOSPD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOSPD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOSPD2 Gene

Disorders for MOSPD2 Gene

Relevant External Links for MOSPD2

Genetic Association Database (GAD)
MOSPD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOSPD2

No disorders were found for MOSPD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOSPD2 Gene

Publications for MOSPD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells. (PMID: 27637333) Gabriel C.H. … Baumgrass R. (J. Biol. Chem. 2016) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for MOSPD2 Gene

Sources for MOSPD2 Gene

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