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Aliases for MOSPD2 Gene

Aliases for MOSPD2 Gene

  • Motile Sperm Domain Containing 2 2 3 5

External Ids for MOSPD2 Gene

Previous GeneCards Identifiers for MOSPD2 Gene

  • GC0XP014253
  • GC0XP014651
  • GC0XP014801
  • GC0XP012649

Summaries for MOSPD2 Gene

GeneCards Summary for MOSPD2 Gene

MOSPD2 (Motile Sperm Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOSPD2 Gene

Genomics for MOSPD2 Gene

Regulatory Elements for MOSPD2 Gene

Enhancers for MOSPD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MOSPD2 on UCSC Golden Path with GeneCards custom track

Promoters for MOSPD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MOSPD2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MOSPD2 gene promoter:

Genomic Location for MOSPD2 Gene

14,873,405 bp from pter
14,922,327 bp from pter
48,923 bases
Plus strand

Genomic View for MOSPD2 Gene

Genes around MOSPD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOSPD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOSPD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOSPD2 Gene

Proteins for MOSPD2 Gene

  • Protein details for MOSPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Motile sperm domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8N3H2
    • Q8NA83

    Protein attributes for MOSPD2 Gene

    518 amino acids
    Molecular mass:
    59746 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MOSPD2 Gene


neXtProt entry for MOSPD2 Gene

Post-translational modifications for MOSPD2 Gene

  • Ubiquitination at Lys 127
  • Modification sites at PhosphoSitePlus

Other Protein References for MOSPD2 Gene

No data available for DME Specific Peptides for MOSPD2 Gene

Domains & Families for MOSPD2 Gene

Suggested Antigen Peptide Sequences for MOSPD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CRAL-TRIO domain.
  • Contains 1 CRAL-TRIO domain.
  • Contains 1 MSP domain.
genes like me logo Genes that share domains with MOSPD2: view

No data available for Gene Families for MOSPD2 Gene

Function for MOSPD2 Gene

Phenotypes for MOSPD2 Gene

genes like me logo Genes that share phenotypes with MOSPD2: view

Animal Model Products

CRISPR Products

miRNA for MOSPD2 Gene

miRTarBase miRNAs that target MOSPD2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOSPD2 Gene

Localization for MOSPD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOSPD2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MOSPD2 Gene COMPARTMENTS Subcellular localization image for MOSPD2 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 2
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MOSPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MOSPD2: view

Pathways & Interactions for MOSPD2 Gene

SuperPathways for MOSPD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOSPD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for MOSPD2 Gene

Drugs & Compounds for MOSPD2 Gene

No Compound Related Data Available

Transcripts for MOSPD2 Gene

Unigene Clusters for MOSPD2 Gene

Motile sperm domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOSPD2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - -
SP5: -

Relevant External Links for MOSPD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MOSPD2 Gene

mRNA expression in normal human tissues for MOSPD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOSPD2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.9) and Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for MOSPD2 Gene

This gene is overexpressed in Bone (22.6) and Spinal cord (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MOSPD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MOSPD2 Gene:


SOURCE GeneReport for Unigene cluster for MOSPD2 Gene:

genes like me logo Genes that share expression patterns with MOSPD2: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MOSPD2 Gene

Orthologs for MOSPD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOSPD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MOSPD2 34
  • 89.68 (n)
  • 89.68 (a)
-- 35
  • 79 (a)
  • 87 (a)
(Canis familiaris)
Mammalia MOSPD2 34
  • 92.34 (n)
  • 94.4 (a)
  • 94 (a)
(Mus musculus)
Mammalia Mospd2 34
  • 86.94 (n)
  • 89.96 (a)
Mospd2 16
Mospd2 35
  • 90 (a)
(Pan troglodytes)
Mammalia MOSPD2 34
  • 99.55 (n)
  • 99.42 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Mospd2 34
  • 86.79 (n)
  • 89.73 (a)
(Monodelphis domestica)
Mammalia MOSPD2 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia MOSPD2 35
  • 72 (a)
(Gallus gallus)
Aves MOSPD2 34
  • 72.42 (n)
  • 71.37 (a)
  • 65 (a)
(Anolis carolinensis)
Reptilia MOSPD2 35
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mospd2 34
  • 67.73 (n)
  • 65.34 (a)
Str.3865 34
(Danio rerio)
Actinopterygii mospd2 34
  • 61.37 (n)
  • 63.81 (a)
wufc48a06 34
mospd2 35
  • 60 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9762 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005556 34
  • 44.57 (n)
  • 33.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33523 34
  • 44.99 (n)
  • 30.33 (a)
CG32407 35
  • 28 (a)
CG33523 35
  • 26 (a)
(Caenorhabditis elegans)
Secernentea hpo-28 34
  • 46.03 (n)
  • 31.2 (a)
hpo-28 35
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CSR1 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
CSA.3857 35
  • 18 (a)
CSA.9460 35
  • 31 (a)
Species where no ortholog for MOSPD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOSPD2 Gene

Gene Tree for MOSPD2 (if available)
Gene Tree for MOSPD2 (if available)

Paralogs for MOSPD2 Gene

(1) SIMAP similar genes for MOSPD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MOSPD2: view

No data available for Paralogs for MOSPD2 Gene

Variants for MOSPD2 Gene

Sequence variations from dbSNP and Humsavar for MOSPD2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs35164803 - 14,911,253(+) GTATA(A/G)CTATC reference, missense
rs747702575 -- 14,904,168(+) ATAAC(C/T)ATAAT intron-variant
rs747722461 -- 14,918,677(+) TTTAA(A/T)AGGTT intron-variant
rs747800472 -- 14,879,288(+) TTTGT(C/G)TTGGG intron-variant
rs747835418 -- 14,901,621(+) GATCA(-/AT)AGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOSPD2 Gene

Variant ID Type Subtype PubMed ID
esv3372386 CNV insertion 20981092
nsv9934 CNV loss 18304495

Variation tolerance for MOSPD2 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOSPD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOSPD2 Gene

Disorders for MOSPD2 Gene

Relevant External Links for MOSPD2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MOSPD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOSPD2 Gene

Publications for MOSPD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 65
  5. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. (PMID: 23192594) Velez Edwards D.R. … Edwards T.L. (Hum. Genet. 2013) 3 65

Products for MOSPD2 Gene

Sources for MOSPD2 Gene