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Aliases for MOSPD1 Gene

Aliases for MOSPD1 Gene

  • Motile Sperm Domain Containing 1 2 3 5
  • Motile Sperm Domain-Containing Protein 1 3
  • DJ473B4 3

External Ids for MOSPD1 Gene

Previous GeneCards Identifiers for MOSPD1 Gene

  • GC0XM132728
  • GC0XM133747
  • GC0XM133849
  • GC0XM134021
  • GC0XM123419

Summaries for MOSPD1 Gene

GeneCards Summary for MOSPD1 Gene

MOSPD1 (Motile Sperm Domain Containing 1) is a Protein Coding gene. Diseases associated with MOSPD1 include Conotruncal Heart Malformations. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is MOSPD3.

Additional gene information for MOSPD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOSPD1 Gene

Genomics for MOSPD1 Gene

Regulatory Elements for MOSPD1 Gene

Enhancers for MOSPD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH134913 1.3 FANTOM5 ENCODE 2.6 +0.4 397 2.1 PKNOX1 ARID4B SIN3A GLI4 ZNF2 ZNF121 ZNF766 ZNF143 ATF7 SP3 ZNF75D INTS6L FAM122B PHF6 RTL8B MOSPD1 GC0XP134864
GH0XH134908 0.9 Ensembl ENCODE 0.4 +6.9 6873 0.7 CTCF ZNF654 GATA2 SMC3 REST ZNF398 PRDM4 RAD21 SMIM10 MOSPD1 GC0XP134864
GH0XH134883 0.7 ENCODE 0.3 +29.3 29271 5.6 TBP PKNOX1 SMARCC1 JUN CEBPB EP300 ZNF121 MAFF PRDM6 GATA3 SMIM10L2B GC0XP134864 MOSPD1
GH0XH134869 0.7 ENCODE 0.2 +46.0 45962 0.2 ZBTB21 JUN INSM2 CEBPB ZEB2 EP300 BRCA1 FOSL1 JUND PRDM6 GC0XP134864 MOSPD1
GH0XH134870 0.4 ENCODE 0.3 +44.6 44631 0.8 ZNF585B TCF7L2 FAM122B RTL8A PHF6 RPL36AP54 GC0XP134864 MOSPD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MOSPD1 on UCSC Golden Path with GeneCards custom track

Promoters for MOSPD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248985 467 1601 PKNOX1 ARID4B SIN3A GLI4 ZNF2 ZNF766 ZNF143 ATF7 SP3 NCOA1

Genomic Locations for MOSPD1 Gene

Genomic Locations for MOSPD1 Gene
27,642 bases
Minus strand

Genomic View for MOSPD1 Gene

Genes around MOSPD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOSPD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOSPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOSPD1 Gene

Proteins for MOSPD1 Gene

  • Protein details for MOSPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Motile sperm domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RE62
    • D3DTG5
    • Q5H9C5
    • Q5H9C7

    Protein attributes for MOSPD1 Gene

    213 amino acids
    Molecular mass:
    24086 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MOSPD1 Gene


neXtProt entry for MOSPD1 Gene

Post-translational modifications for MOSPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MOSPD1 Gene

No data available for DME Specific Peptides for MOSPD1 Gene

Domains & Families for MOSPD1 Gene

Gene Families for MOSPD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MOSPD1 Gene

Suggested Antigen Peptide Sequences for MOSPD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MOSPD1: view

No data available for UniProtKB/Swiss-Prot for MOSPD1 Gene

Function for MOSPD1 Gene

Phenotypes for MOSPD1 Gene

genes like me logo Genes that share phenotypes with MOSPD1: view

Animal Models for MOSPD1 Gene

MGI Knock Outs for MOSPD1:

Animal Model Products

miRNA for MOSPD1 Gene

miRTarBase miRNAs that target MOSPD1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOSPD1 Gene

Localization for MOSPD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOSPD1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOSPD1 gene
Compartment Confidence
nucleus 4
plasma membrane 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MOSPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MOSPD1: view

Pathways & Interactions for MOSPD1 Gene

SuperPathways for MOSPD1 Gene

No Data Available

Interacting Proteins for MOSPD1 Gene

Selected Interacting proteins: Q9UJG1-MSPD1_HUMAN for MOSPD1 Gene via IID

Gene Ontology (GO) - Biological Process for MOSPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS --
genes like me logo Genes that share ontologies with MOSPD1: view

No data available for Pathways by source and SIGNOR curated interactions for MOSPD1 Gene

Drugs & Compounds for MOSPD1 Gene

No Compound Related Data Available

Transcripts for MOSPD1 Gene

Unigene Clusters for MOSPD1 Gene

Motile sperm domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOSPD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - - -
SP2: - -
SP3: - - - - - -
SP4: - - - - - -
SP5: -
SP6: - -
SP7: - - -
SP8: - - - - -

Relevant External Links for MOSPD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MOSPD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOSPD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MOSPD1 Gene

This gene is overexpressed in Bone (54.3) and Pancreatic juice (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MOSPD1 Gene

Protein tissue co-expression partners for MOSPD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOSPD1 Gene:


SOURCE GeneReport for Unigene cluster for MOSPD1 Gene:


Evidence on tissue expression from TISSUES for MOSPD1 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with MOSPD1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOSPD1 Gene

Orthologs for MOSPD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MOSPD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MOSPD1 33 34
  • 100 (n)
(Canis familiaris)
Mammalia MOSPD1 34
  • 97 (a)
LOC481058 33
  • 93.58 (n)
(Bos Taurus)
Mammalia MOSPD1 33 34
  • 93.58 (n)
(Rattus norvegicus)
Mammalia Mospd1 33
  • 92.64 (n)
(Mus musculus)
Mammalia Mospd1 33 16 34
  • 91.71 (n)
(Ornithorhynchus anatinus)
Mammalia MOSPD1 34
  • 88 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 85 (a)
-- 34
  • 84 (a)
(Gallus gallus)
Aves MOSPD1 33 34
  • 84.35 (n)
(Anolis carolinensis)
Reptilia MOSPD1 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mospd1 33
  • 79.03 (n)
Str.17325 33
African clawed frog
(Xenopus laevis)
Amphibia dj473b4-prov 33
(Danio rerio)
Actinopterygii mospd1 33 34
  • 67.45 (n)
Dr.1753 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5949 33
(Caenorhabditis elegans)
Secernentea C34D10.1 33 34
  • 47.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
Species where no ortholog for MOSPD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOSPD1 Gene

Gene Tree for MOSPD1 (if available)
Gene Tree for MOSPD1 (if available)

Paralogs for MOSPD1 Gene

Paralogs for MOSPD1 Gene

(1) SIMAP similar genes for MOSPD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOSPD1: view

Variants for MOSPD1 Gene

Sequence variations from dbSNP and Humsavar for MOSPD1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_036601 A breast cancer sample
rs1000075080 -- 134,894,809(+) CCTAG(A/C)TCAGC intron-variant
rs1000119311 -- 134,913,935(+) AACTA(G/T)AAGTG intron-variant
rs1000263652 -- 134,907,462(+) TGAAA(C/G)AGCTA intron-variant
rs1000272391 -- 134,890,229(+) TTTAT(A/G)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOSPD1 Gene

Variant ID Type Subtype PubMed ID
nsv507997 OTHER sequence alteration 20534489
esv3577265 CNV gain 25503493
esv3577264 CNV gain 25503493

Variation tolerance for MOSPD1 Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOSPD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOSPD1 Gene

Disorders for MOSPD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MOSPD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
conotruncal heart malformations
  • conotruncal heart malformations, variable
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MOSPD1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MOSPD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOSPD1 Gene

Publications for MOSPD1 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. A novel transmembrane MSP-containing protein that plays a role in right ventricle development. (PMID: 15533722) Pall GS … Forrester LM (Genomics 2004) 2 3 60
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60
  5. A Role for MOSPD1 in Mesenchymal Stem Cell Proliferation and Differentiation. (PMID: 26175344) Kara M … Forrester LM (Stem cells (Dayton, Ohio) 2015) 3 60

Products for MOSPD1 Gene

Sources for MOSPD1 Gene

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