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Aliases for MOS Gene

Aliases for MOS Gene

  • MOS Proto-Oncogene, Serine/Threonine Kinase 2 3
  • V-Mos Moloney Murine Sarcoma Viral Oncogene Homolog 2 3 5
  • Oocyte Maturation Factor Mos 3 4
  • Proto-Oncogene C-Mos 3 4
  • EC 2.7.11.1 4 61
  • Proto-Oncogene Serine/Threonine-Protein Kinase Mos 3
  • Oncogene MOS, Moloney Murine Sarcoma Virus 3
  • EC 2.7.11 61
  • C-Mos 3
  • MSV 3

External Ids for MOS Gene

Previous GeneCards Identifiers for MOS Gene

  • GC08M056208
  • GC08M056964
  • GC08M056748
  • GC08M057075
  • GC08M057188
  • GC08M057025
  • GC08M052492

Summaries for MOS Gene

Entrez Gene Summary for MOS Gene

  • MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]

GeneCards Summary for MOS Gene

MOS (MOS Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with MOS include Sarcoma. Among its related pathways are Oocyte meiosis and MAPK signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K21.

Gene Wiki entry for MOS Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOS Gene

Genomics for MOS Gene

Regulatory Elements for MOS Gene

Enhancers for MOS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F056093 0.8 ENCODE 11.5 +20.2 20156 0.2 CTCF ZNF654 STAT1 TBL1XR1 TRIM22 REST ZNF2 RAD21 OSR2 ZNF143 MOS NPM1P21 LOC105375847
GH08F056173 0.8 Ensembl ENCODE 11.2 -59.9 -59898 1.2 JUND JUN BHLHE40 FOS PLAG1 CHCHD7 MOS GC08M056160 ENSG00000221093 GC08M056122
GH08F056167 0.2 ENCODE 10.9 -53.3 -53315 0.2 JUND MOS PLAG1 CHCHD7 GC08M056160 ENSG00000221093 GC08M056122
GH08F056060 0.8 Ensembl ENCODE 10.5 +53.6 53582 0.4 HDAC1 HDGF TBL1XR1 ARNT RAD21 YY1 GATA2 CREM EGR2 ZNF654 MOS PSMC6P1 PIR52236
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MOS on UCSC Golden Path with GeneCards custom track

Genomic Location for MOS Gene

Chromosome:
8
Start:
56,112,942 bp from pter
End:
56,113,982 bp from pter
Size:
1,041 bases
Orientation:
Minus strand

Genomic View for MOS Gene

Genes around MOS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOS Gene

Proteins for MOS Gene

  • Protein details for MOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00540-MOS_HUMAN
    Recommended name:
    Proto-oncogene serine/threonine-protein kinase mos
    Protein Accession:
    P00540
    Secondary Accessions:
    • Q3KPG9
    • Q3KPH0

    Protein attributes for MOS Gene

    Size:
    346 amino acids
    Molecular mass:
    37820 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MOS Gene

Selected DME Specific Peptides for MOS Gene

Post-translational modifications for MOS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MOS Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MOS Gene

Gene Families for MOS Gene

Suggested Antigen Peptide Sequences for MOS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P00540

UniProtKB/Swiss-Prot:

MOS_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MOS: view

Function for MOS Gene

Molecular function for MOS Gene

GENATLAS Biochemistry:
Moloney murine sarcoma viral (v-mos) oncogene homolog (cytostatic factor blocking cells at metaphase)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for MOS Gene

Gene Ontology (GO) - Molecular Function for MOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0004709 MAP kinase kinase kinase activity ISS --
GO:0004871 signal transducer activity IBA --
genes like me logo Genes that share ontologies with MOS: view
genes like me logo Genes that share phenotypes with MOS: view

Animal Models for MOS Gene

MGI Knock Outs for MOS:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MOS

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MOS Gene

Localization for MOS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOS Gene COMPARTMENTS Subcellular localization image for MOS gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005623 cell IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with MOS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MOS Gene

Pathways & Interactions for MOS Gene

genes like me logo Genes that share pathways with MOS: view

Gene Ontology (GO) - Biological Process for MOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000186 activation of MAPKK activity ISS --
GO:0000187 activation of MAPK activity ISS --
GO:0000212 meiotic spindle organization ISS --
GO:0006325 chromatin organization ISS --
genes like me logo Genes that share ontologies with MOS: view

No data available for SIGNOR curated interactions for MOS Gene

Drugs & Compounds for MOS Gene

(8) Drugs for MOS Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for MOS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MOS: view

Transcripts for MOS Gene

mRNA/cDNA for MOS Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MOS Gene

V-mos Moloney murine sarcoma viral oncogene homolog:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MOS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOS Gene

No ASD Table

Relevant External Links for MOS Gene

GeneLoc Exon Structure for
MOS
ECgene alternative splicing isoforms for
MOS

Expression for MOS Gene

mRNA expression in normal human tissues for MOS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOS Gene

This gene is overexpressed in Testis (x21.4), Brain - Hippocampus (x6.8), and Brain - Amygdala (x5.9).

Protein differential expression in normal tissues from HIPED for MOS Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MOS Gene



Protein tissue co-expression partners for MOS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOS Gene:

MOS

SOURCE GeneReport for Unigene cluster for MOS Gene:

Hs.533432

mRNA Expression by UniProt/SwissProt for MOS Gene:

P00540-MOS_HUMAN
Tissue specificity: Expressed specifically in testis during spermatogenesis.
genes like me logo Genes that share expression patterns with MOS: view

Primer Products

Orthologs for MOS Gene

This gene was present in the common ancestor of animals.

Orthologs for MOS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOS 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia MOS 34 35
  • 80.43 (n)
rat
(Rattus norvegicus)
Mammalia Mos 34
  • 77.06 (n)
mouse
(Mus musculus)
Mammalia Mos 34 16 35
  • 76.47 (n)
cow
(Bos Taurus)
Mammalia MOS 34
  • 76 (n)
C-MOS 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MOS 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
ManyToMany
chicken
(Gallus gallus)
Aves MOS 34 35
  • 64.92 (n)
lizard
(Anolis carolinensis)
Reptilia MOS 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489962 34
  • 59.55 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397924 34
zebrafish
(Danio rerio)
Actinopterygii mos 34 35
  • 57.16 (n)
Dr.12572 34
worm
(Caenorhabditis elegans)
Secernentea Y105C5A.24 35
  • 15 (a)
OneToMany
mom-4 35
  • 14 (a)
OneToMany
Species where no ortholog for MOS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOS Gene

ENSEMBL:
Gene Tree for MOS (if available)
TreeFam:
Gene Tree for MOS (if available)

Paralogs for MOS Gene

genes like me logo Genes that share paralogs with MOS: view

Variants for MOS Gene

Sequence variations from dbSNP and Humsavar for MOS Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_040815 A lung adenocarcinoma sample
rs111243120 -- 56,113,255(+) GGGTG(A/T)ATGTG reference, missense
rs111364881 -- 56,115,719(+) GGCAC(C/G)ATCTC upstream-variant-2KB
rs112704048 -- 56,112,903(+) AACAA(A/G)TAGAA downstream-variant-500B
rs112749211 -- 56,115,597(+) TACAA(A/C)CTGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MOS Gene

Variant ID Type Subtype PubMed ID
nsv524526 CNV loss 19592680
nsv831319 CNV gain 17160897

Variation tolerance for MOS Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.34; 70.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOS Gene

Disorders for MOS Gene

MalaCards: The human disease database

(1) MalaCards diseases for MOS Gene - From: GeneCards

Disorder Aliases PubMed IDs
sarcoma
  • connective and soft tissue neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search MOS in MalaCards View complete list of genes associated with diseases

Relevant External Links for MOS

Genetic Association Database (GAD)
MOS
Human Genome Epidemiology (HuGE) Navigator
MOS
Tumor Gene Database (TGDB):
MOS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOS
genes like me logo Genes that share disorders with MOS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOS Gene

Publications for MOS Gene

  1. Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos. (PMID: 20186124) Vitale I. … Kroemer G. (EMBO J. 2010) 3 22 64
  2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 46 64
  3. Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation. (PMID: 18246541) Prasad C.K. … MacNicol A.M. (Mol. Reprod. Dev. 2008) 3 22 64
  4. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 46 64
  5. Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. (PMID: 18550795) Tang W. … Kornbluth S. (Mol. Biol. Cell 2008) 3 22 64

Products for MOS Gene

Sources for MOS Gene

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