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MOS Gene

protein-coding   GIFtS: 59

GC08M057188
v-mos Moloney murine sarcoma viral oncogene homolog
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EC 2.7.11.1 3
MGC119962 2
MGC119963 2
MSV 2
c-mos 3
Descriptions
Oocyte maturation factor mos 2, 3
oncogene MOS, Moloney murine sarcoma virus 2
v-mos Moloney murine sarcoma viral oncogene homolog 2
External Ids
HGNC: 71991
Entrez Gene: 43422
UniProtKB: P005403
Ensembl: ENSG000001726807
Search outside databases for aliases for MOS gene

Previous GC identifers: GC08M056208 GC08M056964 GC08M056748 GC08M057075

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for MOS
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MOS gene  

Entrez Gene cytogenetic band: 8q11   Ensembl cytogenetic band:  8q12.1   HGNC cytogenetic band: 8q11

MOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M057188:     (about GC identifiers)

Start:
57,188,055 bp from pter
End:
57,189,095 bp from pter
Size:
1,041 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000008.9  NT_008183.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MOS_HUMAN, P00540 (See protein sequence)
Recommended Name: Proto-oncogene serine/threonine-protein kinase mos  
Size: 346 amino acids; 37820 Da
Secondary accessions: Q3KPG9 Q3KPH0

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005363.1  

    ENSEMBL proteins: 
    ENSP00000310722 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (MOS)
    Human Recombinant Proteins from Abnova (MOS)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for MOS: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (MOS), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (MOS)
    Novus Biologicals Antibody for MOS

    Assays for MOS: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR017442 Se/Thr_pkinase-rel
     IPR008271 Ser_thr_pkin_AS
     IPR000719 Prot_kinase_core


       GeneDecks  MOS for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P00540

    ProtoNet protein and cluster: P00540

    UniProtKB/Swiss-Prot: MOS_HUMAN, P00540
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MOS)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MOS)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005372

                  Applied Biosystems Silencer® siRNAs for MOS

                  Sigma-Aldrich siRNA and siRNA Panels for MOS  
                         Sigma-Aldrich shRNA Panels and shRNA for MOS  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for MOS
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005372
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005372
                                     untagged cDNA clone in CMV expression vector: NM_005372 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005372

    UniProtKB/Swiss-Prot: MOS_HUMAN, P00540
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme Number (IUBMB): EC 2.7.11.1 

    Genatlas biochemistry entry for MOS:
    Moloney murine sarcoma viral (v-mos) oncogene homolog (cytostatic factor blocking cells at
    metaphase)

    3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mos):

    endocrine/exocrine glandreproductive systemtumorigenesis

    5 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004674 protein serine/threonine kinase activity IEA--
    GO:0005515 protein binding IPI17474147
    GO:0005524 ATP binding IEA--
    GO:0016740 transferase activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for MOS (Maps provided by GeneGo):
     Regulation of G1-S transition

       GeneDecks  MOS for the pathways selected above  
    About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  MOS  (Your Favorite Gene powered by Ingenuity) 
     ERK/MAPK Signaling

       GeneDecks  MOS for the pathways selected above  
    About GeneDecksing

    2 Kegg Pathways  (Kegg details for MOS):
     hsa04010 MAPK signaling pathway
     hsa04810 Regulation of actin cytoskeleton

       GeneDecks  MOS for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  MOS 


    5/21 Interacting proteins for MOS (P005401 ENSP000003107223) via UniProtKB, MINT, and/or STRING (see all 21 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062411EBI-1757866, EBI-515315
    HRASENSP000003733823STRING (score=.818)
    MAP2K1ENSP000003024863STRING (score=.815)
    MAP2K2ENSP000002629483STRING (score=.813)
    ARAFENSP000002902773STRING (score=.8)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein amino acid phosphorylation IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for MOS
    4 Novoseek chemical compound relationships for MOS gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 53.32 14 9755163 (2), 8007949 (2), 10512866 (2), 14751548 (1) (see all 10)
    threonine 42.99 5 9804168 (1), 9256448 (1), 2150599 (1), 7588633 (1) (see all 5)
    atp 0.00 2 7478569 (1), 8405379 (1)
    calcium 0.00 2 1830371 (1), 9486797 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MOS)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MOS)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005372

                  Sigma-Aldrich siRNA and siRNA Panels for MOS  
                         Sigma-Aldrich shRNA Panels and shRNA for MOS  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005372  

    REFSEQ mRNAs for MOS gene: 

    NM_005372.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005372  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005372
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005372
                                     untagged cDNA clone in CMV expression vector: NM_005372 

    Additional cDNA sequence: 

    BC069569.1 BC069590.1 BC106737.1 BC106738.1 

    1 DOTS entry:

    DT.91811430 

    4 AceView cDNA sequences:

    NM_005372 BC069569 BC069590 AY279177 

    highest scoring ESTs for MOS:

    BC069569 BC069590 NM_005372 AY279177 BC106737 BC106738 HG1733-HT1748 

    Unigene Cluster for MOS:

    V-mos Moloney murine sarcoma viral oncogene homolog
    Hs.533432
    Unigene Representative Sequence: NM_005372


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000311923  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    MOS expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for MOS

    1 / 2 / 3

    3 probe-sets matching MOS gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    1174_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 HG1733-HT1748 0.20 1.00 0.72 1

    221367_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005372 0.60 1.00 0.82 1

    221367_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GAGTTCGGTG

    SOURCE GeneReport for Unigene cluster: Hs.533432

    UniProtKB/Swiss-Prot: MOS_HUMAN, P00540
    Tissue specificity: Expressed specifically in testis during spermatogenesis

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for MOS gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MOS1   -- v-mos Moloney murine sarcoma viral oncogene homolog 80.56(n)
    83.97(a)
    486959  XM_544088.2  XP_544088.2 
    chimpanzee
    (Pan troglodytes)
    MOS1   -- v-mos Moloney murine sarcoma viral oncogene homolog 99.71(n)
    99.42(a)
    472772  XM_528144.2  XP_528144.2 
    cow
    (Bos taurus)
    MOS1   -- v-mos Moloney murine sarcoma viral oncogene homolog 76(n)
    74.1(a)
    444869  XM_590874.3  XP_590874.2 
    rat
    (Rattus norvegicus)
    Mos1   -- Moloney sarcoma oncogene 76.23(n)
    72.19(a)
    24559  NM_020102.2  NP_064487.2 
    mouse
    (Mus musculus)
    Mos1, 5 4 (0.00 cM)5
    Moloney sarcoma oncogene1, 5 76.47(n)1
    75(a)1
    174511  NM_020021.21  NP_064405.21 
     AK1330895  AL8073875  (see all 15)
    About this table        Species with no ortholog for MOS

    ENSEMBL Gene Tree for MOS
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for MOS gene
    TNNI3K2  ILK2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/17 NCBI SNPs in MOS are shown (see all 17 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 29)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs70158401,2
    A,C,F,H57190661(+) CAGAAA/GCAATT 1 -- ng317Minor allele frequency- G:0.24EU EA WA NA 552
    rs353927721,2
    C,F57188783(+) CTCAGC/ACCAGA 1 S/A mis14Minor allele frequency- A:0.04EU EA WA 420
    rs29760391,2
    H57187887(-) CAAGTC/TTAGTA 1 -- ng514Minor allele frequency- T:0.00EU EA WA 418
    --
    rs678697771,2
    --57189125(+) GCCGC-/TGGAGT 1 -- ng310--------
    --
    rs353203171,2
    --57189904(+) AGTTA-/CCCGAA 1 -- ng310--------
    --
    rs735923891,2
    --57190832(+) GGCACC/GATCTC 1 -- ng310--------
    --
    rs44345961,2
    --57190300(+) tcctaG/Tctact 1 -- ng310--------
    rs345326351,2
    --57188809(+) CTAGTA/CGGTTC 1 R/L mis10--------
    --
    rs589462001,2
    --57189287(+) AGAAAC/TCGGAA 1 -- ng310--------
    --
    rs132772601,2
    --57188142(+) CAGCGC/GTGGAT 1 Q/H mis10--------
    About this table

    HapMap Linkage Disequilibrium images for MOS (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 190060

    1 Novoseek disease relationship for MOS gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.00 2 1836123 (1), 8549590 (1)
    About this table

    Tumor Gene Database: MOS

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/88 PubMed articles for MOS gene (see all 88 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 4342 HGNC: 7199 AceView: MOS Ensembl:ENSG00000172680 euGenes: HUgn4342
    ECgene: MOS H-InvDB: MOS
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for MOS Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for MOS:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for MOS Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for MOS Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

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     Search OriGene for MOS
     Search Tocris compounds for MOS




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for MOS

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