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Aliases for MOS Gene

Aliases for MOS Gene

  • V-Mos Moloney Murine Sarcoma Viral Oncogene Homolog 2 3
  • Oocyte Maturation Factor Mos 3 4
  • Proto-Oncogene C-Mos 3 4
  • EC 2.7.11.1 4 64
  • Proto-Oncogene Serine/Threonine-Protein Kinase Mos 3
  • Oncogene MOS, Moloney Murine Sarcoma Virus 3
  • EC 2.7.11 64
  • C-Mos 3
  • MSV 3

External Ids for MOS Gene

Summaries for MOS Gene

Entrez Gene Summary for MOS Gene

  • MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]

GeneCards Summary for MOS Gene

MOS (V-Mos Moloney Murine Sarcoma Viral Oncogene Homolog) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is MAP3K9.

Gene Wiki entry for MOS Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOS Gene

Genomics for MOS Gene

Genomic Location for MOS Gene

Start:
56,112,942 bp from pter
End:
56,113,982 bp from pter
Size:
1,041 bases
Orientation:
Minus strand

Genomic View for MOS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOS Gene

Regulatory Elements for MOS Gene

Proteins for MOS Gene

  • Protein details for MOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00540-MOS_HUMAN
    Recommended name:
    Proto-oncogene serine/threonine-protein kinase mos
    Protein Accession:
    P00540
    Secondary Accessions:
    • Q3KPG9
    • Q3KPH0

    Protein attributes for MOS Gene

    Size:
    346 amino acids
    Molecular mass:
    37820 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MOS Gene

Proteomics data for MOS Gene at MOPED

Selected DME Specific Peptides for MOS Gene

Post-translational modifications for MOS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MOS Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for MOS Gene

UniProtKB/Swiss-Prot:

MOS_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • P00540
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.:
    • P00540
genes like me logo Genes that share domains with MOS: view

Function for MOS Gene

Molecular function for MOS Gene

GENATLAS Biochemistry: Moloney murine sarcoma viral (v-mos) oncogene homolog (cytostatic factor blocking cells at metaphase)
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for MOS Gene

Gene Ontology (GO) - Molecular Function for MOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0004709 MAP kinase kinase kinase activity ISS --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MOS: view
genes like me logo Genes that share phenotypes with MOS: view

Animal Models for MOS Gene

MGI Knock Outs for MOS:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for MOS Gene

Localization for MOS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOS Gene COMPARTMENTS Subcellular localization image for MOS gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MOS: view

Pathways for MOS Gene

genes like me logo Genes that share pathways with MOS: view

Gene Ontology (GO) - Biological Process for MOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade ISS --
GO:0000186 activation of MAPKK activity ISS --
GO:0000187 activation of MAPK activity ISS --
GO:0000212 meiotic spindle organization ISS --
GO:0006325 chromatin organization ISS --
genes like me logo Genes that share ontologies with MOS: view

Compounds for MOS Gene

(2) HMDB Compounds for MOS Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(8) Novoseek inferred chemical compound relationships for MOS Gene

Compound -log(P) Hits PubMed IDs
progesterone 53.5 13
threonine 41.5 5
serine 37.9 6
cycloheximide 23.1 2
actinomycin d 18.7 1
genes like me logo Genes that share compounds with MOS: view

Transcripts for MOS Gene

mRNA/cDNA for MOS Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MOS Gene

V-mos Moloney murine sarcoma viral oncogene homolog:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOS Gene

No ASD Table

Relevant External Links for MOS Gene

GeneLoc Exon Structure for
MOS
ECgene alternative splicing isoforms for
MOS

Expression for MOS Gene

mRNA expression in normal human tissues for MOS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOS Gene

This gene is overexpressed in Testis (21.4), Brain - Hippocampus (6.8), and Brain - Amygdala (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MOS Gene

SOURCE GeneReport for Unigene cluster for MOS Gene Hs.533432

mRNA Expression by UniProt/SwissProt for MOS Gene

P00540-MOS_HUMAN
Tissue specificity: Expressed specifically in testis during spermatogenesis
genes like me logo Genes that share expressions with MOS: view

Orthologs for MOS Gene

This gene was present in the common ancestor of animals.

Orthologs for MOS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOS 36
  • 99.71 (n)
  • 99.42 (a)
MOS 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C-MOS 37
  • 73 (a)
OneToOne
MOS 36
  • 76 (n)
  • 74.1 (a)
dog
(Canis familiaris)
Mammalia MOS 36
  • 80.43 (n)
  • 83.72 (a)
MOS 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mos 36
  • 76.47 (n)
  • 75 (a)
Mos 16
Mos 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MOS 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
ManyToMany
rat
(Rattus norvegicus)
Mammalia Mos 36
  • 77.06 (n)
  • 74.12 (a)
chicken
(Gallus gallus)
Aves MOS 36
  • 64.92 (n)
  • 62.79 (a)
MOS 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MOS 37
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397924 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489962 36
  • 59.55 (n)
  • 55.73 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12572 36
mos 36
  • 57.16 (n)
  • 52.04 (a)
mos 37
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mom-4 37
  • 14 (a)
OneToMany
Y105C5A.24 37
  • 15 (a)
OneToMany
Species with no ortholog for MOS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOS Gene

ENSEMBL:
Gene Tree for MOS (if available)
TreeFam:
Gene Tree for MOS (if available)

Paralogs for MOS Gene

genes like me logo Genes that share paralogs with MOS: view

Variants for MOS Gene

Sequence variations from dbSNP and Humsavar for MOS Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2976039 -- 56,112,774(-) CAAGT(C/T)TAGTA downstream-variant-500B
rs4434596 -- 56,115,187(+) tccta(G/T)ctact upstream-variant-2KB
rs6996044 -- 56,115,482(+) GATAG(C/T)AGTTC upstream-variant-2KB
rs7015840 -- 56,115,548(+) CAGAA(A/G)CAATT upstream-variant-2KB
rs13277260 -- 56,113,029(+) CAGCG(C/G)TGGAT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for MOS Gene

Variant ID Type Subtype PubMed ID
nsv831319 CNV Gain 17160897
nsv524526 CNV Loss 19592680

Relevant External Links for MOS Gene

HapMap Linkage Disequilibrium report
MOS

Disorders for MOS Gene

(1) Novoseek inferred disease relationships for MOS Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for MOS

Genetic Association Database (GAD)
MOS
Human Genome Epidemiology (HuGE) Navigator
MOS
Tumor Gene Database (TGDB):
MOS
genes like me logo Genes that share disorders with MOS: view

No data available for UniProtKB/Swiss-Prot for MOS Gene

Publications for MOS Gene

  1. What does Mos do in oocytes and somatic cells? (PMID: 9008413) Sagata N. (Bioessays 1997) 3 23
  2. Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. (PMID: 18550795) Tang W. … Kornbluth S. (Mol. Biol. Cell 2008) 3 23
  3. Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation. (PMID: 18246541) Prasad C.K. … MacNicol A.M. (Mol. Reprod. Dev. 2008) 3 23
  4. Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos. (PMID: 20186124) Vitale I. … Kroemer G. (EMBO J. 2010) 3 23
  5. Mos and the cell cycle. (PMID: 9552420) Singh B. … Arlinghaus R.B. (Prog Cell Cycle Res 1997) 2 3

Products for MOS Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MOS
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MOS
    • Block miRNA regulation of MOS using miScript Target Protectors
    • Addgene plasmids for MOS

    Sources for MOS Gene

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