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MOS Gene

protein-coding   GIFtS: 60
GCID: GC08M057025

V-Mos Moloney Murine Sarcoma Viral Oncogene Homolog

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Mos Moloney Murine Sarcoma Viral Oncogene Homolog1 2     c-mos2
Oocyte Maturation Factor Mos2 3     Oncogene MOS, Moloney Murine Sarcoma Virus2
Proto-Oncogene C-Mos2 3     Proto-Oncogene Serine/Threonine-Protein Kinase Mos2
EC 2.7.11.13 8     EC 2.7.118
MSV2     

External Ids:    HGNC: 71991   Entrez Gene: 43422   Ensembl: ENSG000001726807   OMIM: 1900605   UniProtKB: P005403   

Export aliases for MOS gene to outside databases

Previous GC identifers: GC08M056208 GC08M056964 GC08M056748 GC08M057075 GC08M057188 GC08M052492


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MOS Gene:
MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP
kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 (PubMed 18246541)).(supplied by OMIM, Jul 2009)

GeneCards Summary for MOS Gene:
MOS (v-mos Moloney murine sarcoma viral oncogene homolog) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is FPGT-TNNI3K.

Gene Wiki entry for MOS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the MOS gene promoter:
         AP-1   ATF-2   STAT5A   CUTL1   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOS promoter sequence
   Search Chromatin IP Primers for MOS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MOS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11   Ensembl cytogenetic band:  8q12.1   HGNC cytogenetic band: 8q11

MOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOS gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M057025:  view genomic region     (about GC identifiers)

Start:
57,025,501 bp from pter      End:
57,026,541 bp from pter
Size:
1,041 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MOS_HUMAN, P00540 (See protein sequence)
Recommended Name: Proto-oncogene serine/threonine-protein kinase mos  
Size: 346 amino acids; 37820 Da
Secondary accessions: Q3KPG9 Q3KPH0

Explore the universe of human proteins at neXtProt for MOS: NX_P00540

Explore proteomics data for MOS at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MOS (P00540) (see all 8)
     GGFGSVY  LPRRLAW  SFWAELN  VRVVAAS 


    See MOS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005363.1  
    ENSEMBL proteins: 
     ENSP00000310722  

    MOS Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MOS
    OriGene Custom MassSpec
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    Novus Biologicals MOS Proteins
    Novus Biologicals MOS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MOS

     
    Search eBioscience for Proteins for MOS 

     
    antibodies-online proteins for MOS (12 products) 

     
    antibodies-online peptides for MOS

    MOS Antibody Products:

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    Abcam antibodies for MOS
    Cloud-Clone Corp. Antibodies for MOS
    ThermoFisher Antibodies for MOS
    antibodies-online antibodies for MOS (50 products) 

    MOS Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MOS
    Cloud-Clone Corp. CLIAs for MOS
    Search eBioscience for ELISAs for MOS 
    antibodies-online kits for MOS (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: v-mos Moloney murine sarcoma viral oncogene homolog
    MOS family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P00540

    ProtoNet protein and cluster: P00540

    UniProtKB/Swiss-Prot: MOS_HUMAN, P00540
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MOS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOS_HUMAN, P00540
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for MOS:
    Moloney murine sarcoma viral (v-mos) oncogene homolog (cytostatic factor blocking cells at metaphase)

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004709MAP kinase kinase kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with MOS           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for MOS:
     Altered focal adhesion (FA) or  Decreased Tat-dependent transc  Decreased p24 protein expressi  Decreased substrate adherent c 
     Increased cell death HMECs cel  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mos):
     endocrine/exocrine gland  reproductive system  tumorigenesis 

    Find genes that share phenotypes with MOS           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MOS: Mostm1Gvw Mostm1Ev Mostm1Sia

       genOway: Develop your customized and physiologically relevant rodent model for MOS

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MOS using miScript Target Protectors
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MOS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MOS

    Clone
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    OriGene ORF clones in mouse, rat for MOS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MOS (NM_005372)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOS
    Addgene plasmids for MOS 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MOS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    peroxisome2
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MOS About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Oocyte meiosis
    Oocyte meiosis0.35
    Progesterone-mediated oocyte maturation0.35


    Find genes that share SuperPaths with MOS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for MOS
        MAPK signaling pathway
    Regulation of Actin Cytoskeleton


    4 Kegg Pathways  (Kegg details for MOS):
        MAPK signaling pathway
    Oocyte meiosis
    Regulation of actin cytoskeleton
    Progesterone-mediated oocyte maturation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MOS: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Primary Cilia in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MOS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for MOS (P005402, 3 ENSP000003107224) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ISS--
    GO:0000186activation of MAPKK activity ISS--
    GO:0000187activation of MAPK activity ISS--
    GO:0000212meiotic spindle organization ISS--
    GO:0006325chromatin organization ISS--

    Find genes that share ontologies with MOS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MOS

    2 HMDB Compounds for MOS    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    8 Novoseek inferred chemical compound relationships for MOS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 53.5 14 9755163 (2), 8007949 (2), 10512866 (2), 14751548 (1) (see all 10)
    threonine 41.5 5 9804168 (1), 9256448 (1), 2150599 (1), 7588633 (1) (see all 5)
    serine 37.9 6 9804168 (1), 9256448 (1), 8404868 (1), 2150599 (1) (see all 6)
    cycloheximide 23.1 3 11408585 (1), 9721872 (1)
    actinomycin d 18.7 1 9721872 (1)
    atp 0 2 7478569 (1), 8405379 (1)
    calcium 0 3 1830371 (1), 9486797 (1), 20015408 (1)
    alanine 0 2 16809767 (1), 10838091 (1)



    Find genes that share compounds with MOS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MOS gene: 
    NM_005372.1  

    Unigene Cluster for MOS:

    V-mos Moloney murine sarcoma viral oncogene homolog
    Hs.533432  [show with all ESTs]
    Unigene Representative Sequence: NM_005372
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000311923(uc011leb.2)
    miRNA
    Products:
         
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    Search for qRT-PCR Assays for microRNAs that regulate MOS
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MOS
    Clone
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    OriGene ORF clones in mouse, rat for MOS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MOS (NM_005372)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOS
    Addgene plasmids for MOS 
    Primer
    Products:
        
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MOS
      QuantiTect SYBR Green Assays in human, mouse, rat MOS
      QuantiFast Probe-based Assays in human, mouse, rat MOS

    Additional mRNA sequence: 

    BC069569.1 BC069590.1 BC106737.1 BC106738.1 

    1 DOTS entry:

    DT.91811430 

    4 AceView cDNA sequences:

    NM_005372 BC069569 BC069590 AY279177 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MOS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTTCGGTG
    MOS Expression
    About this image


    MOS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 5 entries
             Primary Oocyte Primary Follicle
             Secondary follicles
     
     Gonad
             Primary Oocyte Primary Follicle
    MOS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MOS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533432

    UniProtKB/Swiss-Prot: MOS_HUMAN, P00540
    Tissue specificity: Expressed specifically in testis during spermatogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MOS: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Primary Cilia in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MOS gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mos1 , 5 Moloney sarcoma oncogene1, 5 76.47(n)1
    75(a)1
      4 (2.16 cM)5
    174511  NM_020021.21  NP_064405.21 
     38706575 
    chicken
    (Gallus gallus)
    Aves MOS1 v-mos Moloney murine sarcoma viral oncogene homolog 64.92(n)
    62.79(a)
      428537  NM_001031516.1  NP_001026687.1 
    lizard
    (Anolis carolinensis)
    Reptilia MOS6
    v-mos Moloney murine sarcoma viral oncogene homolo...
    60(a)
    1 ↔ 1
    GL343244.1(113194-114304)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979242 X.laevis c-mos oncogene mRNA encoding pp39mos, complete more 74.72(n)    X13311.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125722 Danio rerio mRNA for c-Mos, complete cds 73.45(n)    AY046958.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y105C5A.246
    mom-46
    Protein MOM-4 (mom-4) mRNA, complete cds
    15(a)
    14(a)
    1 ↔ many
    1 ↔ many
    IV(15849941-15852900) WBGene00013643
    I(9895692-9900817) WBGene00003396


    ENSEMBL Gene Tree for MOS (if available)
    TreeFam Gene Tree for MOS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MOS gene
    FPGT-TNNI3K2  MAP3K122  MAP3K112  KIAA18042  RAF12  KSR22  KSR12  BRAF2  
    MAP3K92  MAP3K102  ARAF2  MAP3K72  TNNI3K2  ZAK2  MAP3K132  ILK2  

    Find genes that share paralogs with MOS           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MOS (see all 88)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0408154
    A lung adenocarcinoma sample4--see VAR_0408152 A T mis40--------
    rs1468503421,2
    --57025299(+) TAAGAG/TTAGTT 1 -- ds50010--------
    rs1923866471,2
    --57025324(+) GACAAC/TAGGTA 1 -- ds50010--------
    rs29760391,2
    C,H--57025333(-) CAAGTC/TTAGTA 1 -- ds50016Minor allele frequency- T:0.00NS EA NA 422
    rs2013270741,2
    --57025498(+) GTTTTC/GAGTCA 1 -- ds50010--------
    rs1406622881,2
    C,F--57025570(+) GCCGCG/ACTGGG 2 /S syn12Minor allele frequency- A:0.00NA EU 4891
    rs132772601,2
    F--57025588(+) CAGCGG/CTGGAT 2 /H /Q mis12Minor allele frequency- C:0.50NA 4
    rs1469646111,2
    C--57025636(+) AAGACG/CGCAGC 2 /A syn11Minor allele frequency- C:0.00NA 4354
    rs563002241,2,,4
    C,F--57025644(+) AGCGGA/GGAGGG 2 P S mis13Minor allele frequency- G:0.01NS WA NA 4542
    rs2017480331,2
    --57025655(+) ACGGGA/CGCAGG 2 R L mis10--------

    HapMap Linkage Disequilibrium report for MOS (57025501 - 57026541 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MOS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524526CNV Loss19592680
    nsv831319CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MOS
    DNA2.0 Custom Variant and Variant Library Synthesis for MOS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 190060    OMIM disorders: --


    Find genes that share disorders with MOS           About GenesLikeMe

    1 Novoseek inferred disease relationship for MOS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 1836123 (1), 8549590 (1)

    Genetic Association Database (GAD): MOS
    Human Genome Epidemiology (HuGE) Navigator: MOS (16 documents)
    Tumor Gene Database (TGDB): MOS

    Export disorders for MOS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MOS gene, integrated from 10 sources (see all 100):
    (articles sorted by number of sources associating them with MOS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    2. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Mos and the cell cycle. (PubMed id 9552420)1, 3 Singh B. and Arlinghaus R.B. (Prog Cell Cycle Res 1997)
    5. Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus. (PubMed id 6287464)1, 2 Watson R.... Vande Woude G.F. (Proc. Natl. Acad. Sci. U.S.A. 1982)
    6. Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation. (PubMed id 18246541)1, 9 Prasad C.K....MacNicol A.M. (Mol. Reprod. Dev. 2008)
    7. What does Mos do in oocytes and somatic cells? (PubMed id 9008413)1, 9 Sagata N. (Bioessays 1997)
    8. Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos. (PubMed id 20186124)1, 9 Vitale I....Kroemer G. (EMBO J. 2010)
    9. Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. (PubMed id 18550795)1, 9 Tang W....Kornbluth S. (Mol. Biol. Cell 2008)
    10. Changes in aberrant DNA methylation after Helicobacter pylori eradication: a long-term follow-up study. (PubMed id 23595635)1 Shin C.M....Jung H.C. (Int. J. Cancer 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4342 HGNC: 7199 AceView: MOS Ensembl:ENSG00000172680 euGenes: HUgn4342
    ECgene: MOS Kegg: 4342 H-InvDB: MOS

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MOS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MOS Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
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    Patent Information for MOS gene:
    Search GeneIP for patents involving MOS

    GeneCards and IP:
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