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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MOS Gene

protein-coding   GIFtS: 61
GCID: GC08M057025

V-Mos Moloney Murine Sarcoma Viral Oncogene Homolog

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
V-Mos Moloney Murine Sarcoma Viral Oncogene Homolog1 2     c-mos2
Oocyte Maturation Factor Mos2 3     Oncogene MOS, Moloney Murine Sarcoma Virus2
Proto-Oncogene C-Mos2 3     Proto-Oncogene Serine/Threonine-Protein Kinase Mos2
EC 2.7.11.13 8     EC 2.7.118
MSV2     

External Ids:    HGNC: 71991   Entrez Gene: 43422   Ensembl: ENSG000001726807   OMIM: 1900605   UniProtKB: P005403   

Export aliases for MOS gene to outside databases

Previous GC identifers: GC08M056208 GC08M056964 GC08M056748 GC08M057075 GC08M057188 GC08M052492


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MOS Gene:
MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP
kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 (PubMed 18246541)).(supplied by OMIM, Jul 2009)

GeneCards Summary for MOS Gene: 
MOS (v-mos Moloney murine sarcoma viral oncogene homolog) is a protein-coding gene. Diseases associated with MOS include sarcoma, and gastric cancer, and among its related super-pathways are Regulation of actin cytoskeleton and MAPK signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is FPGT-TNNI3K.

Gene Wiki entry for MOS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MOS gene promoter:
         AP-1   ATF-2   STAT5A   CUTL1   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOS promoter sequence
   Search SABiosciences Chromatin IP Primers for MOS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11   Ensembl cytogenetic band:  8q12.1   HGNC cytogenetic band: 8q11

MOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOS gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M057025:  view genomic region     (about GC identifiers)

Start:
57,025,501 bp from pter      End:
57,026,541 bp from pter
Size:
1,041 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MOS_HUMAN, P00540 (See protein sequence)
Recommended Name: Proto-oncogene serine/threonine-protein kinase mos  
Size: 346 amino acids; 37820 Da
Secondary accessions: Q3KPG9 Q3KPH0

Explore the universe of human proteins at neXtProt for MOS: NX_P00540

Explore proteomics data for MOS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P00540

  • 4/8 DME Specific Peptides for MOS (P00540) (see all 8)
     GGFGSVY  LPRRLAW  SFWAELN  VRVVAAS 

    MOS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MOS Protein Expression
    REFSEQ proteins: NP_005363.1  
    ENSEMBL proteins: 
     ENSP00000310722  

    Human Recombinant Protein Products for MOS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MOS
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MOS
    GenScript Custom Purified and Recombinant Proteins Services for MOS
    Novus Biologicals MOS Proteins
    Novus Biologicals MOS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MOS 


    MOS Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for MOS
    GenScript Superior Antibodies for MOS
    Novus Biologicals MOS Antibodies
    Abcam antibodies for MOS
    Cloud-Clone Corp. Antibodies for MOS 
    ThermoFisher Antibodies for MOS
    LSBio Antibodies in human, mouse, rat for MOS 

    Assay Products for MOS: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MOS 
    Cloud-Clone Corp. CLIAs for MOS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: v-mos Moloney murine sarcoma viral oncogene homolog 
    MOS family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P00540

    ProtoNet protein and cluster: P00540

    UniProtKB/Swiss-Prot: MOS_HUMAN, P00540
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    MOS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOS_HUMAN, P00540
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for MOS:
    Moloney murine sarcoma viral (v-mos) oncogene homolog (cytostatic factor blocking cells at metaphase)

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    MOS for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for MOS:
     Altered focal adhesion (FA) or  Decreased Tat-dependent transc  Decreased p24 protein expressi  Decreased substrate adherent c 
     Increased cell death HMECs cel  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mos):
     endocrine/exocrine gland  reproductive system  tumorigenesis 

    MOS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MOS: Mostm1Gvw Mostm1Ev Mostm1Sia

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MOS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MOS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MOS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MOS 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOS
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MOS
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MOS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MOS
    Sirion Biotech Customized adenovirus for overexpression of MOS

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MOS (see all 6)
    OriGene ORF clones in mouse, rat for MOS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MOS (NM_005372)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOS
    Sirion Biotech Customized lentivirus for stable overexpression of MOS 
                         Customized lentivirus expression plasmids for stable overexpression of MOS 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MOS
    Search LifeMap BioReagents cell lines for MOS
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MOS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Oocyte meiosis
    Progesterone-mediated oocyte maturation0.35
    Oocyte meiosis0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for MOS
        MAPK signaling pathway
    Regulation of Actin Cytoskeleton


    4         Kegg Pathways  (Kegg details for MOS):
        MAPK signaling pathway
    Oocyte meiosis
    Regulation of actin cytoskeleton
    Progesterone-mediated oocyte maturation


    MOS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MOS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/24 Interacting proteins for MOS (P005402, 3 ENSP000003107224) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0040020regulation of meiosis IEA--

    MOS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MOS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MOS

    2 HMDB Compounds for MOS    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    8 Novoseek inferred chemical compound relationships for MOS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 53.5 14 9755163 (2), 8007949 (2), 10512866 (2), 14751548 (1) (see all 10)
    threonine 41.5 5 9804168 (1), 9256448 (1), 2150599 (1), 7588633 (1) (see all 5)
    serine 37.9 6 9804168 (1), 9256448 (1), 8404868 (1), 2150599 (1) (see all 6)
    cycloheximide 23.1 3 11408585 (1), 9721872 (1)
    actinomycin d 18.7 1 9721872 (1)
    atp 0 2 7478569 (1), 8405379 (1)
    calcium 0 3 1830371 (1), 9486797 (1), 20015408 (1)
    alanine 0 2 16809767 (1), 10838091 (1)

    Search CenterWatch for drugs/clinical trials and news about MOS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MOS gene: 
    NM_005372.1  

    Unigene Cluster for MOS:

    V-mos Moloney murine sarcoma viral oncogene homolog
    Hs.533432  [show with all ESTs]
    Unigene Representative Sequence: NM_005372
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000311923(uc011leb.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOS
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MOS
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MOS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOS
    Clone
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    OriGene clones in human, mouse for MOS (see all 6)
    OriGene ORF clones in mouse, rat for MOS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MOS (NM_005372)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOS
    Sirion Biotech Customized lentivirus for stable overexpression of MOS 
                         Customized lentivirus expression plasmids for stable overexpression of MOS 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MOS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MOS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOS

    Additional mRNA sequence: 

    BC069569.1 BC069590.1 BC106737.1 BC106738.1 

    1 DOTS entry:

    DT.91811430 

    4 AceView cDNA sequences:

    BC069569 NM_005372 BC069590 AY279177 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MOS expression in normal human tissues (normalized intensities)      MOS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTTCGGTG
    MOS Expression
    About this image


    MOS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 5 entries
             Primary Oocyte Primordial Follicle
             Secondary follicles
     
     Gonad
             Primary Oocyte Primordial Follicle
     
     Neural Tube (Nervous System)
             Prosencephalon

    See MOS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MOS

    SOURCE GeneReport for Unigene cluster: Hs.533432

    UniProtKB/Swiss-Prot: MOS_HUMAN, P00540
    Tissue specificity: Expressed specifically in testis during spermatogenesis

        SABiosciences Expression via Pathway-Focused PCR Arrays including MOS: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Primary Cilia in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MOS gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mos1 , 5 Moloney sarcoma oncogene1, 5 76.47(n)1
    75(a)1
      4 (2.16 cM)5
    174511  NM_020021.21  NP_064405.21 
     38706575 
    chicken
    (Gallus gallus)
    Aves MOS1 v-mos Moloney murine sarcoma viral oncogene homolog 64.83(n)
    62.79(a)
      428537  NM_001031516.1  NP_001026687.1 
    lizard
    (Anolis carolinensis)
    Reptilia MOS6
    Uncharacterized protein
    60(a)
    1 ↔ 1
    GL343244.1(113194-114304)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979242 X.laevis c-mos oncogene mRNA encoding pp39mos, complete more 74.72(n)    X13311.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125722 Danio rerio mRNA for c-Mos, complete cds 73.45(n)    AY046958.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mos6
    mos
    23(a)
    1 ↔ 1
    2R(8638988-8640441)


    ENSEMBL Gene Tree for MOS (if available)
    TreeFam Gene Tree for MOS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MOS gene
    FPGT-TNNI3K2  MAP3K122  MAP3K112  KIAA18042  RAF12  KSR22  KSR12  BRAF2  
    MAP3K102  MAP3K92  ARAF2  MAP3K72  TNNI3K2  ZAK2  MAP3K132  ILK2  

    MOS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/88 SNPs in MOS are shown (see all 88)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0408154
    A lung adenocarcinoma sample4--see VAR_0408152 A T mis40--------
    rs1468503421,2
    --57025299(+) TAAGAG/TTAGTT 1 -- ds50010--------
    rs1923866471,2
    --57025324(+) GACAAC/TAGGTA 1 -- ds50010--------
    rs29760391,2
    C,H--57025333(-) CAAGTC/TTAGTA 1 -- ds50016Minor allele frequency- T:0.00NS EA NA 422
    rs2013270741,2
    --57025498(+) GTTTTC/GAGTCA 1 -- ds50010--------
    rs1406622881,2
    C,F--57025570(+) GCCGCG/ACTGGG 2 /S syn12Minor allele frequency- A:0.00NA EU 4891
    rs132772601,2
    F--57025588(+) CAGCGG/CTGGAT 2 /H /Q mis12Minor allele frequency- C:0.50NA 4
    rs1469646111,2
    C--57025636(+) AAGACG/CGCAGC 2 /A syn11Minor allele frequency- C:0.00NA 4354
    rs563002241,2,4
    C,F--57025644(+) AGCGGA/GGAGGG 2 P S mis13Minor allele frequency- G:0.01NS WA NA 4542
    rs2017480331,2
    --57025655(+) ACGGGA/CGCAGG 2 R L mis10--------

    HapMap Linkage Disequilibrium report for MOS (57025501 - 57026541 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MOS:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv524526CNV Loss19592680
    nsv831319CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MOS
    DNA2.0 Custom Variant and Variant Library Synthesis for MOS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 190060    OMIM disorders: --

    2 diseases for MOS:    About MalaCards
    sarcoma    gastric cancer


    MOS for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MOS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 1836123 (1), 8549590 (1)

    Genetic Association Database (GAD): MOS
    Human Genome Epidemiology (HuGE) Navigator: MOS (16 documents)
    Tumor Gene Database (TGDB): MOS

    Export disorders for MOS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MOS gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with MOS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (2010)
    2. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Mos and the cell cycle. (PubMed id 9552420)1, 3 Singh B. and Arlinghaus R.B. (1997)
    5. Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus. (PubMed id 6287464)1, 2 Watson R.... Vande Woude G.F. (1982)
    6. Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation. (PubMed id 18246541)1, 9 Prasad C.K....MacNicol A.M. (2008)
    7. What does Mos do in oocytes and somatic cells? (PubMed id 9008413)1, 9 Sagata N. (1997)
    8. Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos. (PubMed id 20186124)1, 9 Vitale I....Kroemer G. (2010)
    9. Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. (PubMed id 18550795)1, 9 Tang W....Kornbluth S. (2008)
    10. Prediction of the risk for gastric cancer using candid ate methylation markers in the non-neoplastic gastric mucosae. (PubMed id 22252584)1 Shin C.M....Song I.S. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4342 HGNC: 7199 AceView: MOS Ensembl:ENSG00000172680 euGenes: HUgn4342
    ECgene: MOS Kegg: 4342 H-InvDB: MOS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MOS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MOS Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MOS gene:
    Search GeneIP for patents involving MOS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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