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MORN5 Gene

protein-coding   GIFtS: 42
GCID: GC09P124922

MORN Repeat Containing 5

(Previous names: chromosome 9 open reading frame 113, chromosome 9 open reading...)
(Previous symbols: C9orf113, C9orf18)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MORN Repeat Containing 51 2
C9orf1131 2 3
C9orf181 2 3
Chromosome 9 Open Reading Frame 1131
Chromosome 9 Open Reading Frame 181
MORN Repeat-Containing Protein 52

External Ids:    HGNC: 178411   Entrez Gene: 2549562   Ensembl: ENSG000001856817   UniProtKB: Q5VZ523   

Export aliases for MORN5 gene to outside databases

Previous GC identifers: GC09P123963 GC09P094536


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MORN5 Gene:
MORN5 (MORN repeat containing 5) is a protein-coding gene. Diseases associated with MORN5 include cleft lip.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MORN5 gene promoter:
         GR   GATA-3   GR-beta   Pax-6   POU3F1   HNF-1A   HNF-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMORN5 promoter sequence
   Search Chromatin IP Primers for MORN5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MORN5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.2   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q34.11

MORN5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORN5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P124922:  view genomic region     (about GC identifiers)

Start:
124,922,190 bp from pter      End:
124,962,367 bp from pter
Size:
40,178 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MORN5_HUMAN, Q5VZ52 (See protein sequence)
Recommended Name: MORN repeat-containing protein 5  
Size: 161 amino acids; 18731 Da
Secondary accessions: Q6ZQN1

Explore the universe of human proteins at neXtProt for MORN5: NX_Q5VZ52

Explore proteomics data for MORN5 at MOPED


See MORN5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001273757.1  NP_940871.2  

ENSEMBL proteins: 
 ENSP00000362869   ENSP00000409949   ENSP00000437483  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR003409 MORN

Graphical View of Domain Structure for InterPro Entry Q5VZ52

ProtoNet protein and cluster: Q5VZ52

UniProtKB/Swiss-Prot: MORN5_HUMAN, Q5VZ52
Similarity: Contains 3 MORN repeats


MORN5 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MORN5
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
mitochondrion1
nucleus1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MORN5
Interactions:

    Search GeneGlobe Interaction Network for MORN5

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for MORN5 (ENSP000003628694) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
HSDL1ENSP000002194394STRING: ENSP00000219439
HSPB1ENSP000002485534STRING: ENSP00000248553
HSPD1ENSP000003400194STRING: ENSP00000340019
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MORN5



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MORN5 gene (2 alternative transcripts): 
NM_001286828.1  NM_198469.3  

Unigene Cluster for MORN5:

MORN repeat containing 5
Hs.71428  [show with all ESTs]
Unigene Representative Sequence: AK302081
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000373764(uc004blw.2 uc011lyo.1) ENST00000418632 ENST00000486801
ENST00000477017 ENST00000536616(uc011lyn.2)
miRNA
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Inhib. RNA
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  QuantiFast Probe-based Assays in human, mouse, rat MORN5

Additional mRNA sequence: 

AK128877.1 AK302081.1 BC133690.1 BC143440.1 

4 DOTS entries:

DT.101975341  DT.87014965  DT.92415297  DT.302112 

Selected AceView cDNA sequences (see all 29):

AI597882 AA131402 AI559891 BF435879 AA131502 AI274049 AI656331 AI806072 
NM_198469 AI026684 AW188190 AI797927 AK128877 AW103266 AA978263 AA861425 
AI560944 AI148424 BU730956 AI656213 W19795 AA135775 AA609392 CD693160 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MORN5    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1:                              
SP2:              -               


ECgene alternative splicing isoforms for MORN5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MORN5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGTGGATCAC
MORN5 Expression
About this image


MORN5 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Testis (Reproductive System)
         Mature Sertoli Cells Seminiferous Tubules
MORN5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MORN5 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.71428
    Custom PCR Arrays for MORN5
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORN5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MORN5 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Morn51 , 5 MORN repeat containing 51, 5 80.75(n)1
78.88(a)1
  2 (24.15 cM)5
754951  NM_029309.21  NP_083585.11 
 360494585 
chicken
(Gallus gallus)
Aves MORN51 MORN repeat containing 5 63.54(n)
65(a)
  772256  XM_001235418.3  XP_001235419.3 
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.154642 Transcribed sequence with weak similarity to protein more 73.38(n)    AL879301.2 
zebrafish
(Danio rerio)
Actinopterygii morn51 MORN repeat containing 5 65.62(n)
65.62(a)
  554117  NM_001024413.1  NP_001019584.1 


ENSEMBL Gene Tree for MORN5 (if available)
TreeFam Gene Tree for MORN5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MORN5 gene
2 SIMAP similar genes for MORN5 using alignment to 2 protein entries:     MORN5_HUMAN (see all proteins):
C9orf18    MORN2

MORN5 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MORN5 (see all 883)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1395756911,2
--124924139(+) GGAATC/TTGGGC 1 -- int10--------
rs1132971391,2
C,F--124924160(+) GTTGTG/CTGGTA 1 -- int11Minor allele frequency- C:0.50NA 2
rs1124300651,2
C--124924183(+) CGATAG/CGGATT 1 -- int11Minor allele frequency- C:0.50CSA 2
rs1471998981,2
--124924257(+) GTTATA/GCTTCT 1 -- int10--------
rs1131675991,2
C--124924298(+) CTGATG/TTTGTA 1 -- int11Minor allele frequency- T:0.50CSA 2
rs1396196931,2
--124924507(+) ATCATA/GTATGG 1 -- int10--------
rs2008230271,2
--124924535(+) TAGAT-/ACTC  
        
AATCA
1 -- int10--------
rs109855541,2
C,F,A,H--124924543(+) CAATCA/GATTTT 1 -- int122Minor allele frequency- G:0.22NS EA NA WA 2646
rs1497558801,2
C--124924633(+) TTTAAC/TGTTTG 1 -- int10--------
rs581587591,2
C,F--124924691(+) TGGTAT/CGACTG 1 -- int14Minor allele frequency- C:0.48WA CSA 123

HapMap Linkage Disequilibrium report for MORN5 (124922190 - 124962367 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for MORN5:    About this table    
Variant IDTypeSubtypePubMed ID
nsv6702CNV Insertion18451855
dgv8280n71CNV Loss21882294
nsv831715CNV Gain17160897
nsv893819CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MORN5
DNA2.0 Custom Variant and Variant Library Synthesis for MORN5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for MORN5:    
About MalaCards
cleft lip


MORN5 for disorders           About GeneDecksing

Genetic Association Database (GAD): MORN5
Human Genome Epidemiology (HuGE) Navigator: MORN5 (1 document)

Export disorders for MORN5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MORN5 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MORN5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PubMed id 20583170)1, 4 Letra A....Vieira A.R. (Am. J. Med. Genet. A 2010)
  2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 254956 HGNC: 17841 AceView: C9orf18 Ensembl:ENSG00000185681 euGenes: HUgn254956
ECgene: MORN5 H-InvDB: MORN5

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MORN5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MORN5 gene:
Search GeneIP for patents involving MORN5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Antibodies for MORN5
 ELISAs for MORN5
 CLIAs for MORN5



 Browse ESI BIO Cell Lines and PureStem Progenitors for MORN5
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORN5
 SwitchGear 3'UTR luciferase reporter plasmids for MORN5
 SwitchGear Promoter luciferase reporter plasmids for MORN5
 Search ThermoFisher Antibodies for MORN5
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORN5
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MORN5
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MORN5
 LSBio Antibodies in human, mouse, rat for MORN5
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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