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Aliases for MORN4 Gene

Aliases for MORN4 Gene

  • MORN Repeat Containing 4 2 3 5
  • 44050 Protein 2 3
  • Protein 44050 3 4
  • C10orf83 3 4
  • Chromosome 10 Open Reading Frame 83 2
  • Retinophilin Homolog (Drosophila) 2
  • MORN Repeat-Containing Protein 4 3
  • Retinophilin Homolog 3
  • Retinophilin 4
  • BA548K23.4 3
  • UTA 3
  • Rtp 3

External Ids for MORN4 Gene

Previous HGNC Symbols for MORN4 Gene

  • C10orf83

Previous GeneCards Identifiers for MORN4 Gene

  • GC10M099365
  • GC10M093000

Summaries for MORN4 Gene

GeneCards Summary for MORN4 Gene

MORN4 (MORN Repeat Containing 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MORN4 Gene

  • Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.

Additional gene information for MORN4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORN4 Gene

Genomics for MORN4 Gene

GeneHancer (GH) Regulatory Elements for MORN4 Gene

Promoters and enhancers for MORN4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I097632 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 584.8 +0.7 731 1.6 HDGF ARNT ARID4B SIN3A ZNF2 YY1 ZNF143 FOS SP3 NFYC MORN4 ANKRD2 C10orf62 HOGA1 ENSG00000249967 GC10M097562
GH10I097629 Promoter 0.5 EPDnew 550.8 +4.4 4395 0.1 MORN4 C10orf62 ENSG00000249967 HOGA1 GC10M097562
GH10I097681 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 30.9 -52.5 -52462 9.4 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC AVPI1 MORN4 MARVELD1 ZFYVE27 MMS19 RRP12 R3HCC1L PI4K2A PIR31130 PIR48246
GH10I097639 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.9 -7.0 -7010 2.7 HDGF PKNOX1 FOXA2 ARID4B SIN3A YY1 ZNF213 ZNF143 FOS SP3 PI4K2A R3HCC1L MORN4 ZFYVE27 HPS1 ANKRD2 AVPI1 C10orf62 ENSG00000249967 HOGA1
GH10I097647 Enhancer 1.3 Ensembl ENCODE dbSUPER 32 -16.2 -16193 6 PKNOX1 ATF1 ZFP64 SIN3A NCOA2 TCF12 ZNF121 ZNF766 ATF7 FOS MORN4 MMS19 PI4K2A PIR48481 GC10M097562 ENSG00000249967
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MORN4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MORN4 gene promoter:

Genomic Locations for MORN4 Gene

Genomic Locations for MORN4 Gene
chr10:97,614,553-97,634,156
(GRCh38/hg38)
Size:
19,604 bases
Orientation:
Minus strand
chr10:99,374,310-99,393,913
(GRCh37/hg19)

Genomic View for MORN4 Gene

Genes around MORN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORN4 Gene

Proteins for MORN4 Gene

  • Protein details for MORN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDC4-MORN4_HUMAN
    Recommended name:
    MORN repeat-containing protein 4
    Protein Accession:
    Q8NDC4
    Secondary Accessions:
    • Q86Y54

    Protein attributes for MORN4 Gene

    Size:
    146 amino acids
    Molecular mass:
    16236 Da
    Quaternary structure:
    • Interacts with MYO3A.

    Alternative splice isoforms for MORN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MORN4 Gene

Post-translational modifications for MORN4 Gene

No Post-translational modifications

Other Protein References for MORN4 Gene

No data available for DME Specific Peptides for MORN4 Gene

Domains & Families for MORN4 Gene

Gene Families for MORN4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MORN4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MORN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MORN4: view

No data available for UniProtKB/Swiss-Prot for MORN4 Gene

Function for MORN4 Gene

Molecular function for MORN4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.

Phenotypes From GWAS Catalog for MORN4 Gene

Gene Ontology (GO) - Molecular Function for MORN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MORN4: view
genes like me logo Genes that share phenotypes with MORN4: view

Animal Model Products

miRNA for MORN4 Gene

miRTarBase miRNAs that target MORN4

Clone Products

  • Addgene plasmids for MORN4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MORN4 Gene

Localization for MORN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MORN4 Gene

Cytoplasm. Cell projection, filopodium tip. Cell projection, stereocilium. Note=Found in the cytoplasm in the absence of MYO3A and localizes at filopodial tips in the presence of MYO3A. {ECO:0000269 PubMed:25822849}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MORN4 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MORN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 25822849
GO:0032420 stereocilium IEA --
GO:0032426 stereocilium tip IEA,ISS --
GO:0032433 filopodium tip IDA,IEA 25822849
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with MORN4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MORN4 Gene

Pathways & Interactions for MORN4 Gene

SuperPathways for MORN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MORN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048678 response to axon injury ISS,IEA --
genes like me logo Genes that share ontologies with MORN4: view

No data available for Pathways by source and SIGNOR curated interactions for MORN4 Gene

Drugs & Compounds for MORN4 Gene

No Compound Related Data Available

Transcripts for MORN4 Gene

Unigene Clusters for MORN4 Gene

MORN repeat containing 4:
Representative Sequences:

Clone Products

  • Addgene plasmids for MORN4

Alternative Splicing Database (ASD) splice patterns (SP) for MORN4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for MORN4 Gene

GeneLoc Exon Structure for
MORN4
ECgene alternative splicing isoforms for
MORN4

Expression for MORN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MORN4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MORN4 Gene:

MORN4

SOURCE GeneReport for Unigene cluster for MORN4 Gene:

Hs.217409

Evidence on tissue expression from TISSUES for MORN4 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with MORN4: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MORN4 Gene

Orthologs for MORN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MORN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MORN4 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia MORN4 33 34
  • 94.52 (n)
oppossum
(Monodelphis domestica)
Mammalia MORN4 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MORN4 33 34
  • 92.69 (n)
mouse
(Mus musculus)
Mammalia Morn4 33 16 34
  • 91.78 (n)
rat
(Rattus norvegicus)
Mammalia Morn4 33
  • 91.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MORN4 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves MORN4 33 34
  • 78.54 (n)
lizard
(Anolis carolinensis)
Reptilia MORN4 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia morn4 33
  • 71 (n)
Str.13968 33
zebrafish
(Danio rerio)
Actinopterygii morn4 33 34
  • 69.41 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6686 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003547 33
  • 52.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta rtp 33 34
  • 52.58 (n)
Species where no ortholog for MORN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MORN4 Gene

ENSEMBL:
Gene Tree for MORN4 (if available)
TreeFam:
Gene Tree for MORN4 (if available)

Paralogs for MORN4 Gene

(13) SIMAP similar genes for MORN4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MORN4: view

No data available for Paralogs for MORN4 Gene

Variants for MORN4 Gene

Sequence variations from dbSNP and Humsavar for MORN4 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000059700 -- 97,617,777(-) T/C intron_variant
rs1000182648 -- 97,635,913(-) C/G upstream_transcript_variant
rs1000365068 -- 97,622,342(-) C/G intron_variant
rs1000639820 -- 97,628,008(-) T/C intron_variant
rs1000669596 -- 97,634,429(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MORN4 Gene

Variant ID Type Subtype PubMed ID
nsv1110852 OTHER inversion 24896259

Variation tolerance for MORN4 Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MORN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MORN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MORN4 Gene

Disorders for MORN4 Gene

Additional Disease Information for MORN4

No disorders were found for MORN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MORN4 Gene

Publications for MORN4 Gene

  1. Invertebrate and vertebrate class III myosins interact with MORN repeat-containing adaptor proteins. (PMID: 25822849) Mecklenburg KL … O'Tousa JE (PloS one 2015) 2 3 4 58
  2. A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration. (PMID: 22496551) Bhattacharya MR … DiAntonio A (The Journal of neuroscience : the official journal of the Society for Neuroscience 2012) 2 3 58
  3. Drosophila retinophilin contains MORN repeats and is conserved in humans. (PMID: 17285308) Mecklenburg KL (Molecular genetics and genomics : MGG 2007) 3 4 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for MORN4 Gene

  • Addgene plasmids for MORN4

Sources for MORN4 Gene

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