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MORN3 Gene

protein-coding   GIFtS: 38
GCID: GC12M122089

MORN Repeat Containing 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MORN Repeat Containing 31 2
Membrane Occupation And Recognition Nexus Repeat Containing Protein2
MORN Repeat-Containing Protein 32

External Ids:    HGNC: 298071   Entrez Gene: 2833852   Ensembl: ENSG000001397147   UniProtKB: Q6PF183   

Export aliases for MORN3 gene to outside databases

Previous GC identifers: GC12M120553 GC12M119101


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MORN3 Gene:
MORN3 (MORN repeat containing 3) is a protein-coding gene. An important paralog of this gene is RSPH10B2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MORN3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMORN3 promoter sequence
   Search Chromatin IP Primers for MORN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MORN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

MORN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORN3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M122089:  view genomic region     (about GC identifiers)

Start:
122,089,024 bp from pter      End:
122,110,537 bp from pter
Size:
21,514 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MORN3_HUMAN, Q6PF18 (See protein sequence)
Recommended Name: MORN repeat-containing protein 3  
Size: 240 amino acids; 27585 Da
Secondary accessions: Q86YQ9
Alternative splicing: 2 isoforms:  Q6PF18-1   Q6PF18-2   

Explore the universe of human proteins at neXtProt for MORN3: NX_Q6PF18

Explore proteomics data for MORN3 at MOPED


See MORN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_776254.3  
ENSEMBL proteins: 
 ENSP00000347486   ENSP00000376255   ENSP00000445643  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR003409 MORN

Graphical View of Domain Structure for InterPro Entry Q6PF18

ProtoNet protein and cluster: Q6PF18

UniProtKB/Swiss-Prot: MORN3_HUMAN, Q6PF18
Similarity: Contains 7 MORN repeats


Find genes that share domains with MORN3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MORN3
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol2
extracellular1
mitochondrion1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MORN3
Interactions:

    Search GeneGlobe Interaction Network for MORN3

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for MORN3 (ENSP000003474864) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PNISRENSP000003582424STRING: ENSP00000358242
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MORN3



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MORN3 gene: 
NM_173855.4  

Unigene Cluster for MORN3:

MORN repeat containing 3
Hs.434154  [show with all ESTs]
Unigene Representative Sequence: NM_173855
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000355329(uc001uax.3) ENST00000392462 ENST00000542364(uc001uay.3)

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  QuantiFast Probe-based Assays in human, mouse, rat MORN3

Additional mRNA sequence: 

AY177732.1 BC057760.1 

3 DOTS entries:

DT.95328783  DT.99966842  DT.87046723 

23 AceView cDNA sequences:

CR610648 NM_173855 BM669748 AA100920 BX280057 BQ187501 BC057760 AY177732 
AA478113 AA730148 BX337102 AA758028 AA860341 AA889689 AI024743 BM698955 
AI187763 AA730132 AA398063 CF529474 CB990548 AA082366 BU101629 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MORN3    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:        -                       -               
SP2:                                                


ECgene alternative splicing isoforms for MORN3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MORN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGAATAAAGA
MORN3 Expression
About this image


MORN3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Eye (Sensory Organs)
         Retina
 
 Testis (Reproductive System)
MORN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MORN3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.434154
    Custom PCR Arrays for MORN3
Primer
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QuantiFast Probe-based Assays in human, mouse, rat MORN3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORN3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MORN3 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Morn31 , 5 MORN repeat containing 31, 5 84.59(n)1
84.87(a)1
  5 (62.73 cM)5
748901  NM_029112.11  NP_083388.11 
 1230357695 
chicken
(Gallus gallus)
Aves MORN31 MORN repeat containing 3 62.87(n)
61.18(a)
  100858736  XM_003642178.2  XP_003642226.1 
lizard
(Anolis carolinensis)
Reptilia MORN36
MORN repeat containing 3
55(a)
1 ↔ 1
GL343550.1(153776-154924)
tropical clawed frog
(Xenopus tropicalis)
Amphibia morn31 MORN repeat containing 3 61.43(n)
59.83(a)
  100489796  XM_002937694.2  XP_002937740.1 
zebrafish
(Danio rerio)
Actinopterygii morn31 MORN repeat containing 3 59.52(n)
56.72(a)
  550359  NM_001017666.1  NP_001017666.1 
fruit fly
(Drosophila melanogaster)
Insecta CG144901 CG14490 47.59(n)
38.33(a)
  37041  NM_137430.2  NP_611274.1 


ENSEMBL Gene Tree for MORN3 (if available)
TreeFam Gene Tree for MORN3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MORN3 gene
RSPH10B22  RSPH10B2  MORN12  ALS2CL2  ALS22  RSPH12  
2 SIMAP similar genes for MORN3 using alignment to 1 protein entry:     MORN3_HUMAN:
LOC118812    MORN4

Find genes that share paralogs with MORN3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MORN3 (see all 537)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs600060721,2
C,F--122089034(+) TATTTT/AAAAAT 1 -- int11Minor allele frequency- A:0.50WA 2
rs1435743521,2
C--122089038(+) TTTTT-/TGTAGA 1 -- int10--------
rs745671441,2
C,F--122089121(+) CTTGGC/TCTCCC 1 -- int11Minor allele frequency- T:0.03WA 118
rs1847701301,2
--122089123(+) TGGCCC/TCCCAA 1 -- int10--------
rs1892297221,2
--122089285(+) CATAGA/GCCCAG 1 -- int10--------
rs110433101,2
C,F,H--122089359(+) GGTCCC/TGAGGA 1 -- ut31 ese310Minor allele frequency- T:0.02NS EA NA 1098
rs1816418361,2
--122089398(+) TATTGA/GCAAGA 1 -- ut310--------
rs1444346811,2
C--122089437(+) GCCCTA/GTGAGG 1 -- ut310--------
rs757359191,2
C--122089443(+) TGAGGA/GTGCCG 1 -- ut310--------
rs611034511,2
C,F--122089504(+) CTGAGC/TGATCG 1 -- ut313Minor allele frequency- T:0.12NS WA EA 308

HapMap Linkage Disequilibrium report for MORN3 (122089024 - 122110537 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for MORN3: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MORN3
DNA2.0 Custom Variant and Variant Library Synthesis for MORN3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MORN3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MORN3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  3. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 283385 HGNC: 29807 AceView: LOC283385 Ensembl:ENSG00000139714 euGenes: HUgn283385
ECgene: MORN3 H-InvDB: MORN3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MORN3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MORN3 gene:
Search GeneIP for patents involving MORN3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 SwitchGear Promoter luciferase reporter plasmids for MORN3
 Search ThermoFisher Antibodies for MORN3
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORN3
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MORN3
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MORN3
 LSBio Antibodies in human, mouse, rat for MORN3
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for MORN3
  Search eBioscience for proteins for MORN3
  Search eBioscience for elisas for MORN3
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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