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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MORN3 Gene

protein-coding   GIFtS: 37
GCID: GC12M122089

MORN Repeat Containing 3

  Search for MORN3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MORN Repeat Containing 31 2
Membrane Occupation And Recognition Nexus Repeat Containing Protein2
MORN Repeat-Containing Protein 32

External Ids:    HGNC: 298071   Entrez Gene: 2833852   Ensembl: ENSG000001397147   UniProtKB: Q6PF183   

Export aliases for MORN3 gene to outside databases

Previous GC identifers: GC12M120553 GC12M119101


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MORN3 Gene: 
MORN3 (MORN repeat containing 3) is a protein-coding gene. An important paralog of this gene is RSPH10B2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MORN3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMORN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MORN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MORN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

MORN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORN3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M122089:  view genomic region     (about GC identifiers)

Start:
122,089,024 bp from pter      End:
122,110,537 bp from pter
Size:
21,514 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MORN3_HUMAN, Q6PF18 (See protein sequence)
Recommended Name: MORN repeat-containing protein 3  
Size: 240 amino acids; 27585 Da
Secondary accessions: Q86YQ9
Alternative splicing: 2 isoforms:  Q6PF18-1   Q6PF18-2   

Explore the universe of human proteins at neXtProt for MORN3: NX_Q6PF18

Explore proteomics data for MORN3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6PF18

  • MORN3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MORN3 Protein Expression
    REFSEQ proteins: NP_776254.3  
    ENSEMBL proteins: 
     ENSP00000347486   ENSP00000376255   ENSP00000445643  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003409 MORN

    Graphical View of Domain Structure for InterPro Entry Q6PF18

    ProtoNet protein and cluster: Q6PF18

    UniProtKB/Swiss-Prot: MORN3_HUMAN, Q6PF18
    Similarity: Contains 7 MORN repeats


    MORN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MORN3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MORN3 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MORN3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MORN3

    Search CenterWatch for drugs/clinical trials and news about MORN3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MORN3 gene: 
    NM_173855.4  

    Unigene Cluster for MORN3:

    MORN repeat containing 3
    Hs.434154  [show with all ESTs]
    Unigene Representative Sequence: NM_173855
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355329(uc001uax.3) ENST00000392462 ENST00000542364(uc001uay.3)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMORN3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MORN3
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                         Customized lentivirus expression plasmids for stable overexpression of MORN3 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MORN3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORN3

    Additional mRNA sequence: 

    AY177732.1 BC057760.1 

    3 DOTS entries:

    DT.95328783  DT.99966842  DT.87046723 

    23 AceView cDNA sequences:

    BM669748 NM_173855 AA100920 BC057760 CR610648 BX280057 BQ187501 AY177732 
    AI187763 AA860341 BX337102 AA758028 AA889689 BM698955 AI024743 AA478113 
    AA730148 AA730132 CF529474 AA398063 CB990548 AA082366 BU101629 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MORN3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:        -                       -               
    SP2:                                                


    ECgene alternative splicing isoforms for MORN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MORN3 expression in normal human tissues (normalized intensities)      MORN3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATAAAGA
    MORN3 Expression
    About this image


    MORN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Eye (Sensory Organs)
             retinal amacrine cell p0   
     
     Testis (Reproductive System)

    See MORN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MORN3

    SOURCE GeneReport for Unigene cluster: Hs.434154
        SABiosciences Custom PCR Arrays for MORN3
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORN3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MORN3 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Morn31 , 5 MORN repeat containing 31, 5 84.59(n)1
    84.87(a)1
      5 (62.73 cM)5
    748901  NM_029112.11  NP_083388.11 
     1230357695 
    chicken
    (Gallus gallus)
    Aves LOC1008587361 MORN repeat-containing protein 3-like 63.52(n)
    62.23(a)
      100858736  XM_003642178.1  XP_003642226.1 
    lizard
    (Anolis carolinensis)
    Reptilia MORN36
    Uncharacterized protein
    55(a)
    1 ↔ 1
    GL343550.1(153776-154924)
    zebrafish
    (Danio rerio)
    Actinopterygii morn31 MORN repeat containing 3 59.52(n)
    56.72(a)
      550359  NM_001017666.1  NP_001017666.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG144901 CG14490 48.9(n)
    40.12(a)
      37041  NM_137430.1  NP_611274.1 


    ENSEMBL Gene Tree for MORN3 (if available)
    TreeFam Gene Tree for MORN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MORN3 gene
    RSPH10B22  RSPH10B2  MORN12  ALS2CL2  ALS22  RSPH12  
    2 SIMAP similar genes for MORN3 using alignment to 1 protein entry:     MORN3_HUMAN:
    LOC118812    MORN4

    MORN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/537 SNPs in MORN3 are shown (see all 537)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs600060721,2
    C,F--122089034(+) TATTTT/AAAAAT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1435743521,2
    C--122089038(+) TTTTT-/TGTAGA 1 -- int10--------
    rs745671441,2
    C,F--122089121(+) CTTGGC/TCTCCC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1847701301,2
    --122089123(+) TGGCCC/TCCCAA 1 -- int10--------
    rs1892297221,2
    --122089285(+) CATAGA/GCCCAG 1 -- int10--------
    rs110433101,2
    C,F,H--122089359(+) GGTCCC/TGAGGA 1 -- ut31 ese310Minor allele frequency- T:0.02NS EA NA 1098
    rs1816418361,2
    --122089398(+) TATTGA/GCAAGA 1 -- ut310--------
    rs1444346811,2
    C--122089437(+) GCCCTA/GTGAGG 1 -- ut310--------
    rs757359191,2
    C--122089443(+) TGAGGA/GTGCCG 1 -- ut310--------
    rs611034511,2
    C,F--122089504(+) CTGAGC/TGATCG 1 -- ut313Minor allele frequency- T:0.12NS WA EA 308

    HapMap Linkage Disequilibrium report for MORN3 (122089024 - 122110537 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MORN3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MORN3
    DNA2.0 Custom Variant and Variant Library Synthesis for MORN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MORN3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MORN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    3. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283385 HGNC: 29807 AceView: LOC283385 Ensembl:ENSG00000139714 euGenes: HUgn283385
    ECgene: MORN3 H-InvDB: MORN3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MORN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MORN3 gene:
    Search GeneIP for patents involving MORN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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