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Aliases for MORN3 Gene

Aliases for MORN3 Gene

  • MORN Repeat Containing 3 2 3 5

External Ids for MORN3 Gene

Previous GeneCards Identifiers for MORN3 Gene

  • GC12M120553
  • GC12M122089
  • GC12M119101

Summaries for MORN3 Gene

GeneCards Summary for MORN3 Gene

MORN3 (MORN Repeat Containing 3) is a Protein Coding gene. An important paralog of this gene is RSPH10B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORN3 Gene

Genomics for MORN3 Gene

Regulatory Elements for MORN3 Gene

Enhancers for MORN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F121686 1.7 FANTOM5 Ensembl ENCODE 9.4 -14.3 -14263 1.8 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZCCHC8 KNTC1 PSMD9 SETD1B ANAPC5 ENSG00000272849 MORN3 HPD P2RX4 CAMKK2
GH12F121589 1.7 FANTOM5 Ensembl ENCODE 9.3 +81.3 81331 3.9 HDGF PKNOX1 ATF1 ZNF121 ZNF143 FOS NFYC JUNB TBX21 MBD2 KDM2B ORAI1 MORN3 LINC01089 SETD1B UNC119B RNF34 RHOF GC12P121686
GH12F121625 1.5 FANTOM5 ENCODE 9.3 +44.1 44054 5.8 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SETD1B ZCCHC8 ENSG00000258435 IL31 ENSG00000201945 ENSG00000223538 ENSG00000256963 RPL12P33 LOC101928346 LINC01089
GH12F121708 1.6 FANTOM5 Ensembl ENCODE 8.5 -40.8 -40810 9.8 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 FOS ZNF263 PSMD9 ZCCHC8 KNTC1 SETD1B KDM2B LOC101928346 MIR7107 ENSG00000256950 HPD TMEM120B
GH12F121661 1.3 Ensembl ENCODE 10.2 +8.1 8139 5.4 HDGF PKNOX1 ATF1 ARNT WRNIP1 SIN3A FEZF1 YY1 GTF3C2 FOS ZCCHC8 KNTC1 PSMD9 SETD1B MLXIP ANAPC5 ENSG00000272849 MORN3 ORAI1 HNF1A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MORN3 on UCSC Golden Path with GeneCards custom track

Promoters for MORN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000174317 39 801 HDGF PKNOX1 ARID4B SIN3A ZNF121 GLIS2 ZNF548 SP3 SP5 REST

Genomic Location for MORN3 Gene

Chromosome:
12
Start:
121,648,742 bp from pter
End:
121,672,639 bp from pter
Size:
23,898 bases
Orientation:
Minus strand

Genomic View for MORN3 Gene

Genes around MORN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORN3 Gene

Proteins for MORN3 Gene

  • Protein details for MORN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PF18-MORN3_HUMAN
    Recommended name:
    MORN repeat-containing protein 3
    Protein Accession:
    Q6PF18
    Secondary Accessions:
    • Q86YQ9

    Protein attributes for MORN3 Gene

    Size:
    240 amino acids
    Molecular mass:
    27585 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MORN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MORN3 Gene

Post-translational modifications for MORN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MORN3 Gene

No data available for DME Specific Peptides for MORN3 Gene

Domains & Families for MORN3 Gene

Protein Domains for MORN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MORN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PF18

UniProtKB/Swiss-Prot:

MORN3_HUMAN :
  • Contains 7 MORN repeats.
Similarity:
  • Contains 7 MORN repeats.
genes like me logo Genes that share domains with MORN3: view

No data available for Gene Families for MORN3 Gene

Function for MORN3 Gene

Gene Ontology (GO) - Molecular Function for MORN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MORN3: view

Phenotypes for MORN3 Gene

genes like me logo Genes that share phenotypes with MORN3: view

Animal Model Products

miRNA for MORN3 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MORN3 Gene

Localization for MORN3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MORN3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MORN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with MORN3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MORN3 Gene

Pathways & Interactions for MORN3 Gene

SuperPathways for MORN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MORN3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MORN3 Gene

Transcripts for MORN3 Gene

mRNA/cDNA for MORN3 Gene

Unigene Clusters for MORN3 Gene

MORN repeat containing 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MORN3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - -
SP2:

Relevant External Links for MORN3 Gene

GeneLoc Exon Structure for
MORN3
ECgene alternative splicing isoforms for
MORN3

Expression for MORN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MORN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MORN3 Gene

This gene is overexpressed in Testis (x30.0).

NURSA nuclear receptor signaling pathways regulating expression of MORN3 Gene:

MORN3

SOURCE GeneReport for Unigene cluster for MORN3 Gene:

Hs.434154
genes like me logo Genes that share expression patterns with MORN3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MORN3 Gene

Orthologs for MORN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MORN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MORN3 34 35
  • 98.89 (n)
cow
(Bos Taurus)
Mammalia MORN3 34 35
  • 88.75 (n)
dog
(Canis familiaris)
Mammalia MORN3 34 35
  • 86.53 (n)
mouse
(Mus musculus)
Mammalia Morn3 34 16 35
  • 84.59 (n)
rat
(Rattus norvegicus)
Mammalia Morn3 34
  • 84.31 (n)
oppossum
(Monodelphis domestica)
Mammalia MORN3 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MORN3 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves MORN3 34 35
  • 62.87 (n)
lizard
(Anolis carolinensis)
Reptilia MORN3 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia morn3 34
  • 61.43 (n)
zebrafish
(Danio rerio)
Actinopterygii morn3 34 35
  • 59.52 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14490 34 35
  • 47.59 (n)
CG30429 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToOne
Species where no ortholog for MORN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MORN3 Gene

ENSEMBL:
Gene Tree for MORN3 (if available)
TreeFam:
Gene Tree for MORN3 (if available)

Paralogs for MORN3 Gene

Paralogs for MORN3 Gene

(2) SIMAP similar genes for MORN3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MORN3: view

Variants for MORN3 Gene

Sequence variations from dbSNP and Humsavar for MORN3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10743188 -- 121,661,008(+) TGTTG(C/G)CTATG intron-variant
rs10770190 -- 121,653,446(+) AAAAA(A/T)TTTTT intron-variant
rs11043310 -- 121,651,453(+) GGTCC(C/T)GAGGA nc-transcript-variant, utr-variant-3-prime
rs11043311 -- 121,652,315(+) tgcaa(A/C)cttca intron-variant
rs11043312 -- 121,654,275(+) TCACT(C/T)AGGCG intron-variant, nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MORN3 Gene

Variant ID Type Subtype PubMed ID
esv3630952 CNV loss 21293372
nsv1053272 CNV gain 25217958
nsv1145633 CNV deletion 24896259
nsv560458 CNV loss 21841781

Variation tolerance for MORN3 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MORN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MORN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MORN3 Gene

Disorders for MORN3 Gene

Relevant External Links for MORN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MORN3

No disorders were found for MORN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MORN3 Gene

Publications for MORN3 Gene

  1. Characterization of membrane occupation and recognition nexus repeat containing 3, meiosis expressed gene 1 binding partner, in mouse male germ cells. (PMID: 25248657) Zhang L. … Zhang Z.B. (Asian J. Androl. 2015) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N. … Roth F.P. (Mol. Syst. Biol. 2016) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64

Products for MORN3 Gene

Sources for MORN3 Gene

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