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MORN2 Gene

protein-coding   GIFtS: 38
GCID: GC02P039103

MORN Repeat Containing 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MORN Repeat Containing 21 2
MOPT2 3
MORN Motif Protein In Testis2 3
BLOCK272
MORN Repeat-Containing Protein 22
Protein Containing Single MORN Motif In Testis2

External Ids:    HGNC: 301661   Entrez Gene: 7299672   Ensembl: ENSG000001880107   UniProtKB: Q502X03   

Export aliases for MORN2 gene to outside databases

Previous GC identifers: GC02P039015 GC02P038956 GC02P038841


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MORN2 Gene:
MORN2 (MORN repeat containing 2) is a protein-coding gene. Diseases associated with MORN2 include lateral sclerosis, and amyotrophic lateral sclerosis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MORN2 gene promoter:
         Oct-B1   POU2F2 (Oct-2.1)   oct-B3   oct-B2   CUTL1   POU2F2   Evi-1   AREB6   POU2F1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MORN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MORN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22.1

MORN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORN2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P039103:  view genomic region     (about GC identifiers)

Start:
39,103,103 bp from pter      End:
39,156,213 bp from pter
Size:
53,111 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MORN2_HUMAN, Q502X0 (See protein sequence)
Recommended Name: MORN repeat-containing protein 2  
Size: 79 amino acids; 8939 Da
Secondary accessions: Q6UL00

Explore the universe of human proteins at neXtProt for MORN2: NX_Q502X0

REFSEQ proteins: NP_001138922.1  
ENSEMBL proteins: 
 ENSP00000344551   ENSP00000386563   ENSP00000401340   ENSP00000386874   ENSP00000387161  
 ENSP00000387181  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR003409 MORN

Graphical View of Domain Structure for InterPro Entry Q502X0

ProtoNet protein and cluster: Q502X0

UniProtKB/Swiss-Prot: MORN2_HUMAN, Q502X0
Similarity: Contains 2 MORN repeats


MORN2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MORN2
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hsa-mir-197-3p (MIRT048107)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
extracellular2
nucleus1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MORN2
Interactions:

    Search GeneGlobe Interaction Network for MORN2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for MORN2 (Q502X02, 3 ENSP000003445514) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
MPP3Q133682, 3MINT-64789 I2D: score=3 
CCNB1IP1ENSP000003373964STRING: ENSP00000337396
DLG3ENSP000003634804STRING: ENSP00000363480
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MORN2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MORN2 gene (2 alternative transcripts): 
NM_194270.1  NM_001145450.1  

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000340556(uc010fak.3) ENST00000410014 ENST00000441049 ENST00000409665
ENST00000409077 ENST00000409131
miRNA
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GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MORN2    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5
SP1:                    -                           
SP2:                                                


ECgene alternative splicing isoforms for MORN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MORN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAGATGTGAT
MORN2 Expression
About this image

MORN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
    Custom PCR Arrays for MORN2
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORN2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MORN2 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Morn21 , 5 MORN repeat containing 21, 5 86.92(n)1
92.41(a)1
  17 (50.63 cM)5
3784621  NM_194269.21  NP_919245.11 
 802902125 
chicken
(Gallus gallus)
Aves MORN21 MORN repeat containing 2 67.51(n)
68.35(a)
  101751661  XM_004935277.1  XP_004935334.1 
lizard
(Anolis carolinensis)
Reptilia MORN26
MORN repeat containing 2
46(a)
1 ↔ 1
1(253970545-253974164)
tropical clawed frog
(Xenopus tropicalis)
Amphibia morn21 MORN repeat containing 2 71.73(n)
70.89(a)
  100488991  XM_002933869.2  XP_002933915.2 
zebrafish
(Danio rerio)
Actinopterygii morn21 MORN repeat containing 2 60.76(n)
60.76(a)
  751675  NM_001261426.1  NP_001248355.1 


ENSEMBL Gene Tree for MORN2 (if available)
TreeFam Gene Tree for MORN2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MORN2 gene
12 SIMAP similar genes for MORN2 using alignment to 4 protein entries:     MORN2_HUMAN (see all proteins):
ANKMY1    DKFZp686L21237    RSPH10B    SETD7    DKFZp779I2251    JPH1
RSPH10B2    RSPH1    C9orf18    MORN1    MORN5    ALS2

MORN2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MORN2 (see all 108)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2010967761,2
C--39105056(+) CTCAG-/CCCCCC 1 -- int10--------
rs1930094271,2
--39105097(+) ACACCC/TAGCTA 1 -- int10--------
rs1830653581,2
--39105162(+) GAACTC/TCTAGG 1 -- int10--------
rs574024481,2
C,F--39105320(+) GTCTCG/AGAATT 1 -- int11Minor allele frequency- A:0.50WA 2
rs1874017541,2
--39105385(+) TTGTAC/GTTTAT 1 -- int10--------
rs1918487051,2
--39105687(+) TTTTCC/TAGCCA 1 -- int10--------
rs1840788091,2
--39105692(+) CAGCCA/GTCTCA 1 -- int10--------
rs67445141,2
C,F,A,H--39105735(+) TTCAAG/CCTAAT 1 -- int112Minor allele frequency- C:0.49NS EA NA CSA WA 756
rs1884096541,2
--39105751(+) AGTTCA/GCTAAT 1 -- int10--------
rs729131191,2
C,F--39105763(+) TGTTTG/TCAATT 1 -- int11Minor allele frequency- T:0.50WA 2

HapMap Linkage Disequilibrium report for MORN2 (39103103 - 39156213 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for MORN2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv2692CNV Loss18451855

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MORN2
DNA2.0 Custom Variant and Variant Library Synthesis for MORN2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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3 diseases for MORN2:    
About MalaCards
lateral sclerosis    amyotrophic lateral sclerosis    obesity


MORN2 for disorders           About GeneDecksing

Genetic Association Database (GAD): MORN2

Export disorders for MORN2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MORN2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MORN2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PubMed id 19451621)1, 4 Landers J.E....Brown R.H. (Proc. Natl. Acad. Sci. U.S.A. 2009)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
  5. Identification and characterization of a novel mouse and human MOPT gene containing MORN-motif protein in testis. (PubMed id 19913896)1 Choi Y.J....Kim J.H. (Theriogenology 2010)
  6. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PubMed id 17924679)1 Yu L.R.... Veenstra T.D. (J. Proteome Res. 2007)
  7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  9. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)
  10. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 729967 HGNC: 30166 Ensembl:ENSG00000188010 euGenes: HUgn729967 ECgene: MORN2
H-InvDB: MORN2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MORN2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MORN2 gene:
Search GeneIP for patents involving MORN2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MORN2
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MORN2
 Search LSBio for Antibodies for MORN2
Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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