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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MORN2 Gene

protein-coding   GIFtS: 40
GCID: GC02P039103

MORN repeat containing 2
 Explore 2 diseases affiliated with
MORN2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MORN2    

Aliases
for MORN2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
MORN Repeat Containing 21 2
MOPT1 2 3
MORN Motif Protein In Testis2 3
BLOCK272
MORN Repeat-Containing Protein 22
Protein Containing Single MORN Motif In Testis2

External Ids:    HGNC: 301661   Entrez Gene: 7299672   Ensembl: ENSG000001880107   UniProtKB: Q502X03   

Export aliases for MORN2 gene to outside databases

Previous GC identifers: GC02P039015 GC02P038956 GC02P038841


Summaries
for MORN2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for MORN2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MORN2 gene promoter:
         Oct-B1   POU2F2 (Oct-2.1)   oct-B3   oct-B2   CUTL1   POU2F2   Evi-1   AREB6   POU2F1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MORN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MORN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22.1

MORN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORN2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P039103:  view genomic region     (about GC identifiers)

Start:
 39,103,103 bp from pter      End:
 39,156,213 bp from pter
Size:
 53,111 bases      Orientation:
 plus strand

Proteins
for MORN2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MORN2_HUMAN, Q502X0 (See protein sequence)
Recommended Name: MORN repeat-containing protein 2  
Size: 79 amino acids; 8939 Da
Secondary accessions: Q6UL00

Explore the universe of human proteins at neXtProt for MORN2: NX_Q502X0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q502X0

    • MORN2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001138922.1  
    ENSEMBL proteins: 
     ENSP00000344551   ENSP00000386563   ENSP00000401340   ENSP00000386874   ENSP00000387161  
     ENSP00000387181  

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    Uscn Proteins for MORN2


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    Uscn ELISAs and CLIAs for MORN2

    Protein Domains /
    Families
    for MORN2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MORN2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003409 MORN

    Graphical View of Domain Structure for InterPro Entry Q502X0

    ProtoNet protein and cluster: Q502X0

    UniProtKB/Swiss-Prot: MORN2_HUMAN, Q502X0
    Similarity: Contains 2 MORN repeats


    Function
    for MORN2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for MORN2

    In Situ Assay
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    Pathways & Interactions
    for MORN2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MORN2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for MORN2 (Q502X02, 3 ENSP000003445514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPP3Q133682, 3MINT-64789 I2D: score=3 
    CCNB1IP1ENSP000003373964STRING: ENSP00000337396
    DLG3ENSP000003634804STRING: ENSP00000363480
    About this table

    Drugs & Compounds
    for MORN2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MORN2
    Search CenterWatch for drugs/clinical trials and news about MORN2 

    Transcripts
    for MORN2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MORN2 gene (2 alternative transcripts): 
    NM_194270.1  NM_001145450.1  

    Unigene Cluster for MORN2:

    MORN repeat containing 2
    Hs.729207  [show with all ESTs]
    Unigene Representative Sequence: BQ948934
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340556(uc010fak.3) ENST00000410014 ENST00000441049 ENST00000409665
    ENST00000409077 ENST00000409131

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MORN2 (see all 7)
    OriGene shRNA RFP: MORN2
    OriGene siRNA: MORN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MORN2
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORN2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MORN2
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORN2

    Additional cDNA sequence: 

    AY367766.1 BC095472.1 BC102032.1 BC102034.1 BC102035.1 

    5 DOTS entries:

    DT.101980530  DT.91660564  DT.99993788  DT.121005504  DT.95204563 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MORN2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5
    SP1:                    -                           
    SP2:                                                


    ECgene alternative splicing isoforms for MORN2

    Expression
    for MORN2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MORN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGATGTGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MORN2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MORN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MORN2

    SOURCE GeneReport for Unigene cluster: Hs.729207
        SABiosciences Custom PCR Arrays for MORN2
    Primer
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    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORN2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORN2

    Orthologs
    for MORN2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MORN2 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Morn21 , 5 MORN repeat containing 21, 5 86.92(n)1
    92.41(a)1    		   17 (50.63 cM)5
    3784621  NM_194269.21  NP_919245.11 
     802902125 
    chicken
    (Gallus gallus)    		 Aves MORN26
    		 Uncharacterized protein
    		 68(a)
    		 1 ↔ 1
    		 3(17586870-17589281)
    lizard
    (Anolis carolinensis)    		 Reptilia MORN26
    		 --
    		 46(a)
    		 1 ↔ 1
    		 1(253970545-253974164)
    zebrafish
    (Danio rerio)    		 Actinopterygii morn21 MORN repeat containing 2 60.76(n)
    60.76(a)    		   751675  XM_001923638.3  XP_001923673.1 


    ENSEMBL Gene Tree for MORN2 (if available)
    TreeFam Gene Tree for MORN2 (if available) 

    Paralogs
    for MORN2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MORN2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/86 NCBI SNPs in MORN2 are shown (see all 86)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2010967761,2
    		--39105056(+) CTCAG-/CCCCCC 1 -- int10--------
    rs1930094271,2
    		--39105097(+) ACACCC/TAGCTA 1 -- int10--------
    rs1830653581,2
    		--39105162(+) GAACTC/TCTAGG 1 -- int10--------
    rs714022591,2
    		C,--39105262(+) CATGAT/-TTTTA 1 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs574024481,2
    		C,--39105320(+) GTCTCG/AGAATT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1874017541,2
    		--39105385(+) TTGTAC/GTTTAT 1 -- int10--------
    rs1918487051,2
    		--39105687(+) TTTTCC/TAGCCA 1 -- int10--------
    rs1840788091,2
    		--39105692(+) CAGCCA/GTCTCA 1 -- int10--------
    rs67445141,2
    		C,F,A,H,--39105735(+) TTCAAG/CCTAAT 1 -- int112Minor allele frequency- C:0.49NS EA NA CSA WA 756
    rs1884096541,2
    		--39105751(+) AGTTCA/GCTAAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for MORN2 (39103103 - 39156213 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MORN2: --

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MORN2

    Disorders / Diseases
    for MORN2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MORN2 for disorders           About GeneDecksing

    2 diseases for MORN2:    About MalaCards
    amyotrophic lateral sclerosis    lateral sclerosis


    Export disorders for MORN2 gene to outside databases

    Publications
    for MORN2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MORN2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MORN2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Identification and characterization of a novel mouse and human MOPT gene containing MORN-motif protein in testis. (PubMed id 19913896)1 Choi Y.J....Kim J.H. (2010)
    4. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PubMed id 19451621)1 Landers J.E....Brown R.H. (2009)
    5. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PubMed id 17924679)1 Yu L.-R.... Veenstra T.D. (2007)
    6. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    8. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for MORN2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MORN2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 729967 HGNC: 30166 Ensembl:ENSG00000188010 euGenes: HUgn729967 ECgene: MORN2
    H-InvDB: MORN2

    Other Databases showing MORN2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MORN2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MORN2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MORN2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MORN2 gene:
    Search GeneIP for patents involving MORN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MORN2 gene

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    About This Section

     
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