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Aliases for MORN2 Gene

Aliases for MORN2 Gene

  • MORN Repeat Containing 2 2 3 5
  • MORN Motif Protein In Testis 3 4
  • MOPT 3 4
  • Protein Containing Single MORN Motif In Testis 3
  • MORN Repeat-Containing Protein 2 3
  • BLOCK27 3

External Ids for MORN2 Gene

Previous GeneCards Identifiers for MORN2 Gene

  • GC02P039015
  • GC02P038956
  • GC02P039103
  • GC02P038841

Summaries for MORN2 Gene

GeneCards Summary for MORN2 Gene

MORN2 (MORN Repeat Containing 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MORN2 Gene

  • Might have a role in spermatogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORN2 Gene

Genomics for MORN2 Gene

Regulatory Elements for MORN2 Gene

Enhancers for MORN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F038852 0.8 FANTOM5 11.7 -23.7 -23711 0.2 DHX57 MORN2 ARHGEF33 SRSF7 GC02P038853 LOC105374470
GH02F038907 0.6 ENCODE 11.6 +32.2 32214 2.1 ZFP64 ARID4B ZNF48 CBX5 ZNF202 SP5 JUNB REST ZNF623 PPARG SOS1 ASS1P2 DHX57 ARHGEF33 RNU6-851P MORN2 ENSG00000225284 GC02M038898 GC02P038937
GH02F038906 0.2 ENCODE 11.4 +30.4 30393 0.2 FOXK2 ZNF610 BCL6 THAP11 MORN2 DHX57 GC02M038898 GC02P038937
GH02F038908 0.6 ENCODE 11.4 +30.7 30690 0.2 FOXK2 ZNF610 THAP11 MORN2 DHX57 GC02M038898 GC02P038937
GH02F038840 0.3 FANTOM5 11.3 -35.2 -35191 0.2 ENSG00000225284 GEMIN6 SRSF7 MORN2 DHX57 LOC105374470 GC02P038853
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MORN2 on UCSC Golden Path with GeneCards custom track

Promoters for MORN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000012547 -162 2401 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS SP3

Genomic Location for MORN2 Gene

Chromosome:
2
Start:
38,875,962 bp from pter
End:
38,929,072 bp from pter
Size:
53,111 bases
Orientation:
Plus strand

Genomic View for MORN2 Gene

Genes around MORN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORN2 Gene

Proteins for MORN2 Gene

  • Protein details for MORN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q502X0-MORN2_HUMAN
    Recommended name:
    MORN repeat-containing protein 2
    Protein Accession:
    Q502X0
    Secondary Accessions:
    • Q6UL00

    Protein attributes for MORN2 Gene

    Size:
    79 amino acids
    Molecular mass:
    8939 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MORN2 Gene

Post-translational modifications for MORN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MORN2 Gene

No data available for DME Specific Peptides for MORN2 Gene

Domains & Families for MORN2 Gene

Protein Domains for MORN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MORN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q502X0

UniProtKB/Swiss-Prot:

MORN2_HUMAN :
  • Contains 2 MORN repeats.
Similarity:
  • Contains 2 MORN repeats.
genes like me logo Genes that share domains with MORN2: view

No data available for Gene Families for MORN2 Gene

Function for MORN2 Gene

Molecular function for MORN2 Gene

UniProtKB/Swiss-Prot Function:
Might have a role in spermatogenesis.

Gene Ontology (GO) - Molecular Function for MORN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MORN2: view

Phenotypes for MORN2 Gene

GenomeRNAi human phenotypes for MORN2:
genes like me logo Genes that share phenotypes with MORN2: view

Animal Model Products

miRNA for MORN2 Gene

miRTarBase miRNAs that target MORN2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MORN2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MORN2 Gene

Localization for MORN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MORN2 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Nucleus. Note=Associated with the acrosome during post-meiotic stages of spermatogenesis. Appears to migrate to the nucleus during the final step of spermiogenesis. {ECO:0000250 UniProtKB:Q6UL01}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MORN2 Gene COMPARTMENTS Subcellular localization image for MORN2 gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 2

Gene Ontology (GO) - Cellular Components for MORN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with MORN2: view

Pathways & Interactions for MORN2 Gene

SuperPathways for MORN2 Gene

No Data Available

Interacting Proteins for MORN2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000344551%0d%0a9606.ENSP00000234160%0d%0a
Selected Interacting proteins: ENSP00000344551 Q502X0-MORN2_HUMAN for MORN2 Gene via STRING IID UniProtKB

Gene Ontology (GO) - Biological Process for MORN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MORN2: view

No data available for Pathways by source and SIGNOR curated interactions for MORN2 Gene

Transcripts for MORN2 Gene

mRNA/cDNA for MORN2 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MORN2 Gene

MORN repeat containing 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MORN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MORN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5
SP1: -
SP2:

Relevant External Links for MORN2 Gene

GeneLoc Exon Structure for
MORN2
ECgene alternative splicing isoforms for
MORN2

Expression for MORN2 Gene

mRNA expression in normal human tissues for MORN2 Gene

mRNA differential expression in normal tissues according to GTEx for MORN2 Gene

This gene is overexpressed in Testis (x6.5).

NURSA nuclear receptor signaling pathways regulating expression of MORN2 Gene:

MORN2

SOURCE GeneReport for Unigene cluster for MORN2 Gene:

Hs.729207
genes like me logo Genes that share expression patterns with MORN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MORN2 Gene

Orthologs for MORN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MORN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MORN2 34 35
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia MORN2 34 35
  • 92.83 (n)
dog
(Canis familiaris)
Mammalia MORN2 34 35
  • 92.83 (n)
rat
(Rattus norvegicus)
Mammalia Morn2 34
  • 87.34 (n)
mouse
(Mus musculus)
Mammalia Morn2 34 16 35
  • 86.92 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MORN2 35
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves MORN2 34
  • 67.51 (n)
lizard
(Anolis carolinensis)
Reptilia MORN2 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia morn2 34
  • 71.73 (n)
zebrafish
(Danio rerio)
Actinopterygii morn2 34 35
  • 60.76 (n)
Species where no ortholog for MORN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MORN2 Gene

ENSEMBL:
Gene Tree for MORN2 (if available)
TreeFam:
Gene Tree for MORN2 (if available)

Paralogs for MORN2 Gene

(12) SIMAP similar genes for MORN2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MORN2: view

No data available for Paralogs for MORN2 Gene

Variants for MORN2 Gene

Sequence variations from dbSNP and Humsavar for MORN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1010858 -- 38,875,529(-) GGGGG(A/G)GCGGG intron-variant, upstream-variant-2KB
rs1010859 -- 38,875,386(-) TGGAT(A/G)TCTGG intron-variant, upstream-variant-2KB
rs111405064 -- 38,882,137(+) TTGTT(C/T)TGGTT intron-variant
rs111427348 -- 38,882,054(+) CATTG(A/G)TAGTG intron-variant
rs111473531 -- 38,874,566(+) CACCA(G/T)GCCCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MORN2 Gene

Variant ID Type Subtype PubMed ID
nsv2692 CNV deletion 18451855

Variation tolerance for MORN2 Gene

Gene Damage Index Score: 4.74; 66.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MORN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MORN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MORN2 Gene

Disorders for MORN2 Gene

Relevant External Links for MORN2

Genetic Association Database (GAD)
MORN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MORN2

No disorders were found for MORN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MORN2 Gene

Publications for MORN2 Gene

  1. Identification and characterization of a novel mouse and human MOPT gene containing MORN-motif protein in testis. (PMID: 19913896) Choi Y.J. … Kim J.H. (Theriogenology 2010) 3 4 64
  2. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PMID: 19451621) Landers J.E. … Brown R.H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for MORN2 Gene

Sources for MORN2 Gene

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