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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MORN2 Gene

protein-coding   GIFtS: 40
GCID: GC02P039103

MORN Repeat Containing 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MORN Repeat Containing 21 2
MOPT2 3
MORN Motif Protein In Testis2 3
BLOCK272
MORN Repeat-Containing Protein 22
Protein Containing Single MORN Motif In Testis2

External Ids:    HGNC: 301661   Entrez Gene: 7299672   Ensembl: ENSG000001880107   UniProtKB: Q502X03   

Export aliases for MORN2 gene to outside databases

Previous GC identifers: GC02P039015 GC02P038956 GC02P038841


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MORN2 Gene: 
MORN2 (MORN repeat containing 2) is a protein-coding gene. Diseases associated with MORN2 include lateral sclerosis, and amyotrophic lateral sclerosis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MORN2 gene promoter:
         Oct-B1   POU2F2 (Oct-2.1)   oct-B3   oct-B2   CUTL1   POU2F2   Evi-1   AREB6   POU2F1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MORN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MORN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22.1

MORN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORN2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P039103:  view genomic region     (about GC identifiers)

Start:
39,103,103 bp from pter      End:
39,156,213 bp from pter
Size:
53,111 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MORN2_HUMAN, Q502X0 (See protein sequence)
Recommended Name: MORN repeat-containing protein 2  
Size: 79 amino acids; 8939 Da
Secondary accessions: Q6UL00

Explore the universe of human proteins at neXtProt for MORN2: NX_Q502X0

Explore proteomics data for MORN2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q502X0

  • MORN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MORN2 Protein Expression
    REFSEQ proteins: NP_001138922.1  
    ENSEMBL proteins: 
     ENSP00000344551   ENSP00000386563   ENSP00000401340   ENSP00000386874   ENSP00000387161  
     ENSP00000387181  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003409 MORN

    Graphical View of Domain Structure for InterPro Entry Q502X0

    ProtoNet protein and cluster: Q502X0

    UniProtKB/Swiss-Prot: MORN2_HUMAN, Q502X0
    Similarity: Contains 2 MORN repeats


    MORN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MORN2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MORN2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MORN2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for MORN2 (Q502X02, 3 ENSP000003445514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPP3Q133682, 3MINT-64789 I2D: score=3 
    CCNB1IP1ENSP000003373964STRING: ENSP00000337396
    DLG3ENSP000003634804STRING: ENSP00000363480
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MORN2

    Search CenterWatch for drugs/clinical trials and news about MORN2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MORN2 gene (2 alternative transcripts): 
    NM_194270.1  NM_001145450.1  

    Unigene Cluster for MORN2:

    MORN repeat containing 2
    Hs.729207  [show with all ESTs]
    Unigene Representative Sequence: BQ948934
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340556(uc010fak.3) ENST00000410014 ENST00000441049 ENST00000409665
    ENST00000409077 ENST00000409131
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MORN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MORN2
    Clone
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    GenScript: all cDNA clones in your preferred vector: MORN2 (NM_001145450)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MORN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORN2
    Sirion Biotech Customized lentivirus for stable overexpression of MORN2 
                         Customized lentivirus expression plasmids for stable overexpression of MORN2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MORN2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MORN2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MORN2
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORN2

    Additional mRNA sequence: 

    AY367766.1 BC095472.1 BC102032.1 BC102034.1 BC102035.1 

    5 DOTS entries:

    DT.101980530  DT.91660564  DT.99993788  DT.121005504  DT.95204563 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MORN2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5
    SP1:                    -                           
    SP2:                                                


    ECgene alternative splicing isoforms for MORN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MORN2 expression in normal human tissues (normalized intensities)      MORN2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGATGTGAT
    MORN2 Expression
    About this image


    MORN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Kidney (Urinary System)

    See MORN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MORN2

    SOURCE GeneReport for Unigene cluster: Hs.729207
        SABiosciences Custom PCR Arrays for MORN2
    Primer
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    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORN2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MORN2 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Morn21 , 5 MORN repeat containing 21, 5 86.92(n)1
    92.41(a)1
      17 (50.63 cM)5
    3784621  NM_194269.21  NP_919245.11 
     802902125 
    lizard
    (Anolis carolinensis)
    Reptilia MORN26
    Uncharacterized protein
    46(a)
    1 ↔ 1
    1(253970545-253974164)
    zebrafish
    (Danio rerio)
    Actinopterygii morn21 MORN repeat containing 2 60.76(n)
    60.76(a)
      751675  XM_001923638.3  XP_001923673.1 


    ENSEMBL Gene Tree for MORN2 (if available)
    TreeFam Gene Tree for MORN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MORN2 gene
    12 SIMAP similar genes for MORN2 using alignment to 4 protein entries:     MORN2_HUMAN (see all proteins):
    ANKMY1    DKFZp686L21237    RSPH10B    SETD7    DKFZp779I2251    JPH1
    RSPH10B2    RSPH1    C9orf18    MORN1    MORN5    ALS2

    MORN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/108 SNPs in MORN2 are shown (see all 108)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2010967761,2
    C--39105056(+) CTCAG-/CCCCCC 1 -- int10--------
    rs1930094271,2
    --39105097(+) ACACCC/TAGCTA 1 -- int10--------
    rs1830653581,2
    --39105162(+) GAACTC/TCTAGG 1 -- int10--------
    rs574024481,2
    C,F--39105320(+) GTCTCG/AGAATT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1874017541,2
    --39105385(+) TTGTAC/GTTTAT 1 -- int10--------
    rs1918487051,2
    --39105687(+) TTTTCC/TAGCCA 1 -- int10--------
    rs1840788091,2
    --39105692(+) CAGCCA/GTCTCA 1 -- int10--------
    rs67445141,2
    C,F,A,H--39105735(+) TTCAAG/CCTAAT 1 -- int112Minor allele frequency- C:0.49NS EA NA CSA WA 756
    rs1884096541,2
    --39105751(+) AGTTCA/GCTAAT 1 -- int10--------
    rs729131191,2
    C,F--39105763(+) TGTTTG/TCAATT 1 -- int11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for MORN2 (39103103 - 39156213 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MORN2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2692CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MORN2
    DNA2.0 Custom Variant and Variant Library Synthesis for MORN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for MORN2:    About MalaCards
    lateral sclerosis    amyotrophic lateral sclerosis


    MORN2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MORN2

    Export disorders for MORN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MORN2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MORN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PubMed id 19451621)1, 4 Landers J.E....Brown R.H. (2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    5. Identification and characterization of a novel mouse and human MOPT gene containing MORN-motif protein in testis. (PubMed id 19913896)1 Choi Y.J....Kim J.H. (2010)
    6. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PubMed id 17924679)1 Yu L.-R.... Veenstra T.D. (2007)
    7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    9. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 729967 HGNC: 30166 Ensembl:ENSG00000188010 euGenes: HUgn729967 ECgene: MORN2
    H-InvDB: MORN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MORN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MORN2 gene:
    Search GeneIP for patents involving MORN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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