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MORN1 Gene

protein-coding   GIFtS: 43
GCID: GC01M002242

MORN Repeat Containing 1

  Search for MORN1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MORN Repeat Containing 11 2
MORN Repeat-Containing Protein 12

External Ids:    HGNC: 258521   Entrez Gene: 799062   Ensembl: ENSG000001161517   UniProtKB: Q5T0893   

Export aliases for MORN1 gene to outside databases

Previous GC identifers: GC01M002285 GC01M001527


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MORN1 Gene:
MORN1 (MORN repeat containing 1) is a protein-coding gene. An important paralog of this gene is RSPH10B2.

Gene Wiki entry for MORN1 (Morn repeat containing 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MORN1 gene promoter:
         GR   p53   Pax-5   GR-beta   SREBP-1c   LUN-1   SREBP-1b   C/EBPalpha   CHOP-10   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMORN1 promoter sequence
   Search Chromatin IP Primers for MORN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MORN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33-p36.32   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36.33-p36.32

MORN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORN1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M002242:  view genomic region     (about GC identifiers)

Start:
2,252,692 bp from pter      End:
2,323,146 bp from pter
Size:
70,455 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MORN1_HUMAN, Q5T089 (See protein sequence)
Recommended Name: MORN repeat-containing protein 1  
Size: 497 amino acids; 53850 Da
Secondary accessions: A6NKZ6 Q8WW30 Q9H852
Alternative splicing: 2 isoforms:  Q5T089-1   Q5T089-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MORN1: NX_Q5T089

Explore proteomics data for MORN1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MORN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079124.1  
    ENSEMBL proteins: 
     ENSP00000367792   ENSP00000367790   ENSP00000367786   ENSP00000390261   ENSP00000476189  

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    Cloud-Clone Corp. CLIAs for MORN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003409 MORN

    Graphical View of Domain Structure for InterPro Entry Q5T089

    ProtoNet protein and cluster: Q5T089

    UniProtKB/Swiss-Prot: MORN1_HUMAN, Q5T089
    Similarity: Contains 7 MORN repeats


    MORN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MORN1
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    Predesigned siRNA for gene silencing in human, mouse, rat MORN1

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MORN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORN1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    extracellular1
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MORN1
    Interactions:

        Search GeneGlobe Interaction Network for MORN1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MORN1 (ENSP000003677924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MORN1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MORN1 gene: 
    NM_024848.1  

    Unigene Cluster for MORN1:

    MORN repeat containing 1
    Hs.642701  [show with all ESTs]
    Unigene Representative Sequence: AK128431
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378531(uc001ajb.1 uc009vld.3) ENST00000606372 ENST00000378529(uc001ajd.1)
    ENST00000607342 ENST00000469374 ENST00000419785 ENST00000378525(uc010nyy.2)
    ENST00000449373 ENST00000607031 ENST00000475812 ENST00000494279
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMORN1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MORN1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORN1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MORN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MORN1
      QuantiTect SYBR Green Assays in human, mouse, rat MORN1
      QuantiFast Probe-based Assays in human, mouse, rat MORN1

    Additional mRNA sequence: 

    AK024003.1 AK055432.1 AK128431.1 AK299217.1 AK310323.1 BC021704.2 BC063141.1 

    15 DOTS entries:

    DT.410850  DT.97762308  DT.445410  DT.40131103  DT.121455848  DT.86668022  DT.95141413  DT.99949740 
    DT.100750103  DT.91983603  DT.121455896  DT.121455724  DT.121455884  DT.40251532  DT.121455904 

    Selected AceView cDNA sequences (see all 59):

    BE857126 BQ641612 AU142770 BM724843 BE503006 AI634393 BF115685 NM_024848 
    BF110617 AI188092 AK024003 CF890862 AI651083 AA393516 AI201111 BM977810 
    AW137355 AI968144 CB305904 CF887462 AK128431 BG055482 BE217747 AI458216 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MORN1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                -           -           -           -                 -                       -                           
    SP2:                                -           -           -           -                 -                                                   
    SP3:                                            -                       -                                                                     
    SP4:                                                                                      -                                                   
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for MORN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MORN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGCATCCC
    MORN1 Expression
    About this image


    MORN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
     
     Gonad
             Primordial germ cell-like cells
     
     Epiblast (Early Embryonic Tissues)
             Epiblast-like cells
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    MORN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MORN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.642701
        Custom PCR Arrays for MORN1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MORN1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Morn11 , 5 MORN repeat containing 11, 5 76.95(n)1
    70.21(a)1
      4 (86.17 cM)5
    768661  NM_001081100.11  NP_001074569.11 
     1550865775 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia morn11 MORN repeat containing 1 54.08(n)
    47.9(a)
      100487673  XM_002936560.2  XP_002936606.2 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii BX861298.12   -- 68.89(n)    BX861298.1 


    ENSEMBL Gene Tree for MORN1 (if available)
    TreeFam Gene Tree for MORN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MORN1 gene
    RSPH10B22  RSPH10B2  ALS2CL2  ALS22  RSPH12  MORN32  
    5 SIMAP similar genes for MORN1 using alignment to 4 protein entries:     MORN1_HUMAN (see all proteins):
    SETD7    MORN4    MORN2    RSPH10B2    LOC118812

    MORN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MORN1 (see all 1731)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs360961961,2
    C,F--2252205(-) CTGACG/ACCCCC 1 -- ds50013Minor allele frequency- A:0.17NA EA 242
    rs124069761,2
    C,A,H--2252280(+) TCCTGT/CGGGCA 1 -- ds50016Minor allele frequency- C:0.31NS EA NA 658
    rs1889850451,2
    --2252353(+) CAGAGC/TTCTGC 1 -- ds50010--------
    rs341219361,2
    C--2252401(-) GAATT-/CCCCTG 1 -- ds50010--------
    rs1998258361,2
    --2252405(+) AGGGG-/AATTCC 1 -- ds50010--------
    rs785943301,2
    C,F--2252418(+) CACCAA/GCCGCG 1 -- ds50011Minor allele frequency- G:0.03EA 120
    rs1817397321,2
    C--2252422(+) AACCGC/GGGCTG 1 -- ds50010--------
    rs1403976801,2
    --2252626(+) CGCCCA/TTGAGT 1 -- ds50010--------
    rs1443343931,2
    --2252670(+) GTGGGG/TCCCAA 1 -- ds50010--------
    rs1477672211,2
    --2252698(+) AGCCGC/TCACTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MORN1 (2252692 - 2323146 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MORN1 (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4742CNV Insertion18451855
    dgv70n71CNV Loss21882294
    nsv834668CNV Loss17160897
    dgv67n71CNV Loss21882294
    nsv470682CNV Loss18288195
    dgv73n71CNV Loss21882294
    dgv72n71CNV Loss21882294
    nsv871848CNV Loss21882294
    dgv74n71CNV Loss21882294
    nsv520511CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MORN1
    DNA2.0 Custom Variant and Variant Library Synthesis for MORN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MORN1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MORN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79906 HGNC: 25852 AceView: FLJ13941 Ensembl:ENSG00000116151 euGenes: HUgn79906
    ECgene: MORN1 H-InvDB: MORN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MORN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MORN1 gene:
    Search GeneIP for patents involving MORN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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