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Aliases for MORN1 Gene

Aliases for MORN1 Gene

  • MORN Repeat Containing 1 2 3 5

External Ids for MORN1 Gene

Previous GeneCards Identifiers for MORN1 Gene

  • GC01M002285
  • GC01M002242
  • GC01M001527

Summaries for MORN1 Gene

GeneCards Summary for MORN1 Gene

MORN1 (MORN Repeat Containing 1) is a Protein Coding gene. An important paralog of this gene is RSPH10B.

Gene Wiki entry for MORN1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORN1 Gene

Genomics for MORN1 Gene

Regulatory Elements for MORN1 Gene

Enhancers for MORN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F002203 1.4 FANTOM5 ENCODE 26.3 +184.7 184715 7.7 CREB3L1 MLX ARID4B DMAP1 ZNF2 YY1 ZNF143 DEK SP3 SP5 MORN1 MIR6727 CCNL2 FAAP20 LOC100288379 SKI LOC100129534 LINC01786 RER1 ENSG00000240731
GH01F002269 1.3 Ensembl ENCODE 26.4 +116.7 116695 10.9 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF207 MORN1 SKI LOC100129534 MIR6727 RER1 ENSG00000240731 ENSG00000272455 SLC35E2 MIB2 CCNL2
GH01F002173 1.3 Ensembl ENCODE 26 +217.4 217396 1.8 MLX ARID4B DMAP1 ZNF2 GLIS2 ZNF143 ZNF263 SP5 ZHX2 REST MORN1 MIR6727 LOC100129534 LINC01786 RER1 ENSG00000240731 ENSG00000272455 SLC35E2 MIB2 CCNL2
GH01F003345 2.1 VISTA FANTOM5 Ensembl ENCODE 14.9 -959.2 -959184 10.8 PKNOX1 ATF1 CREB3L1 MLX ARID4B FEZF1 ZNF48 ZNF2 ZNF121 GLIS2 ENSG00000231630 ENSG00000233234 MORN1 TP73-AS1 LOC100129534 ENSG00000229393 PRDM16 GC01M003355 LOC105378604
GH01F002287 1.6 FANTOM5 Ensembl ENCODE 15 +100.3 100251 7.8 ATF1 ARID4B YY1 ZNF121 GLIS2 FOS ZNF623 NFIL3 SMARCA4 RCOR2 MORN1 LOC100129534 MIR6727 ENSG00000240731 ENSG00000272455 SLC35E2 MIB2 CCNL2 SLC35E2B LOC100129381
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MORN1 on UCSC Golden Path with GeneCards custom track

Promoters for MORN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000074174 51 2201 PKNOX1 CREB3L1 ARID4B SIN3A YY1 ZNF143 FOS ZNF263 SP3 SP5

Genomic Location for MORN1 Gene

Chromosome:
1
Start:
2,321,253 bp from pter
End:
2,391,751 bp from pter
Size:
70,499 bases
Orientation:
Minus strand

Genomic View for MORN1 Gene

Genes around MORN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORN1 Gene

Proteins for MORN1 Gene

  • Protein details for MORN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T089-MORN1_HUMAN
    Recommended name:
    MORN repeat-containing protein 1
    Protein Accession:
    Q5T089
    Secondary Accessions:
    • A6NKZ6
    • Q8WW30
    • Q9H852

    Protein attributes for MORN1 Gene

    Size:
    497 amino acids
    Molecular mass:
    53850 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MORN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MORN1 Gene

Post-translational modifications for MORN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MORN1 Gene

Domains & Families for MORN1 Gene

Protein Domains for MORN1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5T089

UniProtKB/Swiss-Prot:

MORN1_HUMAN :
  • Contains 7 MORN repeats.
Similarity:
  • Contains 7 MORN repeats.
genes like me logo Genes that share domains with MORN1: view

No data available for Gene Families for MORN1 Gene

Function for MORN1 Gene

Phenotypes for MORN1 Gene

genes like me logo Genes that share phenotypes with MORN1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MORN1 Gene

Localization for MORN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MORN1 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2
extracellular 1
cytoskeleton 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MORN1 Gene

Pathways & Interactions for MORN1 Gene

SuperPathways for MORN1 Gene

No Data Available

Interacting Proteins for MORN1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000367792%0d%0a9606.ENSP00000368924%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000340019%0d%0a
Selected Interacting proteins: Q5T089-MORN1_HUMAN ENSP00000367792 for MORN1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for MORN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MORN1 Gene

Transcripts for MORN1 Gene

Unigene Clusters for MORN1 Gene

MORN repeat containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MORN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5:
SP6: -

Relevant External Links for MORN1 Gene

GeneLoc Exon Structure for
MORN1
ECgene alternative splicing isoforms for
MORN1

Expression for MORN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MORN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MORN1 Gene

This gene is overexpressed in Brain - Cerebellum (x5.1) and Brain - Cerebellar Hemisphere (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of MORN1 Gene:

MORN1

SOURCE GeneReport for Unigene cluster for MORN1 Gene:

Hs.642701
genes like me logo Genes that share expression patterns with MORN1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MORN1 Gene

Orthologs for MORN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MORN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MORN1 34 35
  • 99.03 (n)
dog
(Canis familiaris)
Mammalia MORN1 34 35
  • 78.14 (n)
mouse
(Mus musculus)
Mammalia Morn1 34 16 35
  • 76.95 (n)
cow
(Bos Taurus)
Mammalia MORN1 34 35
  • 76.85 (n)
rat
(Rattus norvegicus)
Mammalia Morn1 34
  • 74.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MORN1 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MORN1 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia morn1 34
  • 54.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToOne
Species where no ortholog for MORN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MORN1 Gene

ENSEMBL:
Gene Tree for MORN1 (if available)
TreeFam:
Gene Tree for MORN1 (if available)

Paralogs for MORN1 Gene

Paralogs for MORN1 Gene

(5) SIMAP similar genes for MORN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MORN1: view

Variants for MORN1 Gene

Sequence variations from dbSNP and Humsavar for MORN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10159277 -- 2,355,708(+) CTGCA(A/G)ACAGT intron-variant
rs10218501 -- 2,333,938(+) AGTGG(A/G)CTCTT intron-variant, utr-variant-3-prime
rs1039063 -- 2,350,539(+) GGGGG(G/T)TGAGT intron-variant, nc-transcript-variant
rs1039064 -- 2,350,540(+) GGGGT(C/T)GAGTG intron-variant, nc-transcript-variant
rs1039100 -- 2,355,508(+) CTTCT(A/G)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MORN1 Gene

Variant ID Type Subtype PubMed ID
nsv951557 CNV deletion 24416366
nsv834668 CNV loss 17160897
nsv823697 CNV gain 20364138
nsv823031 CNV gain 20364138
nsv520511 CNV loss 19592680
nsv482937 CNV loss 15286789
nsv4742 CNV insertion 18451855
nsv470682 CNV loss 18288195
nsv1133791 CNV deletion 24896259
nsv1003233 CNV gain 25217958
esv3585024 CNV loss 21293372
esv3577699 CNV loss 25503493
esv2502867 CNV loss 19546169

Variation tolerance for MORN1 Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MORN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MORN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MORN1 Gene

Disorders for MORN1 Gene

Relevant External Links for MORN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MORN1

No disorders were found for MORN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MORN1 Gene

Publications for MORN1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for MORN1 Gene

Sources for MORN1 Gene

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