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Aliases for MORF4L2 Gene

Aliases for MORF4L2 Gene

  • Mortality Factor 4 Like 2 2 3 5
  • Transcription Factor-Like Protein MRGX 3 4
  • MORF-Related Gene X Protein 3 4
  • Protein MSL3-2 3 4
  • MRGX 3 4
  • Mortality Factor 4-Like Protein 2 3
  • MORF-Related Gene X 2
  • MSL3-2 Protein 3
  • KIAA0026 4
  • MORFL2 3

External Ids for MORF4L2 Gene

Previous GeneCards Identifiers for MORF4L2 Gene

  • GC0XM099839
  • GC0XM100963
  • GC0XM101702
  • GC0XM102736
  • GC0XM102817
  • GC0XM102930
  • GC0XM092587

Summaries for MORF4L2 Gene

GeneCards Summary for MORF4L2 Gene

MORF4L2 (Mortality Factor 4 Like 2) is a Protein Coding gene. Diseases associated with MORF4L2 include Paraneoplastic Cerebellar Degeneration. Among its related pathways are Chromatin organization. An important paralog of this gene is MORF4L1.

UniProtKB/Swiss-Prot for MORF4L2 Gene

  • Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.

Gene Wiki entry for MORF4L2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORF4L2 Gene

Genomics for MORF4L2 Gene

Regulatory Elements for MORF4L2 Gene

Enhancers for MORF4L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG103655 1.1 Ensembl ENCODE 13.6 +30.5 30473 4.2 TBP FOXA2 BRCA1 RFX5 GATA2 ZNF366 RCOR1 FOS EGR2 CEBPB BEX4 MORF4L2-AS1 MORF4L2 TCEAL3 ZCCHC18 TCEAL1 TCEAL3-AS1 BHLHB9 PLP1 FAM199X
GH0XG103537 1 FANTOM5 Ensembl ENCODE 1.5 +149.2 149171 2.0 GATA3 REST BEX4 TCEAL3 TCEAL4 MORF4L2 RAB40A
GH0XG103690 0.7 dbSUPER 0.4 -5.5 -5461 7.1 SOX5 SOX13 CTCF ZNF654 MAZ FOXA2 FOXA3 RAD21 RARA ZNF335 PLP1 TCEAL3 BEX4 BEX2 ZCCHC18 BEX3 MORF4L2 TMEM31
GH0XG103698 0.7 dbSUPER 0.4 -11.0 -10951 0.8 PKNOX1 ESRRA ZNF687 DPF2 FOXA1 ZNF217 MBD2 CTBP1 GATA3 MTA1 PLP1 TMEM31 MORF4L2
GH0XG103701 0.7 dbSUPER 0.4 -19.0 -18983 10.8 HDGF CTCF MXI1 MAX BMI1 ZIC2 RAD21 ZNF664 GATA3 ZBTB48 GLRA4 PLP1 TCEAL3 BEX4 BEX2 TMEM31 MORF4L2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MORF4L2 on UCSC Golden Path with GeneCards custom track

Promoters for MORF4L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247734 1358 3600 PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF207 ZNF143

Genomic Location for MORF4L2 Gene

Chromosome:
X
Start:
103,675,496 bp from pter
End:
103,688,158 bp from pter
Size:
12,663 bases
Orientation:
Minus strand

Genomic View for MORF4L2 Gene

Genes around MORF4L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORF4L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORF4L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORF4L2 Gene

Proteins for MORF4L2 Gene

  • Protein details for MORF4L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15014-MO4L2_HUMAN
    Recommended name:
    Mortality factor 4-like protein 2
    Protein Accession:
    Q15014
    Secondary Accessions:
    • B3KP92
    • D3DXA5
    • Q567V0
    • Q8J026

    Protein attributes for MORF4L2 Gene

    Size:
    288 amino acids
    Molecular mass:
    32308 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with MRFAP1 and RB1. May also interact with one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors.

neXtProt entry for MORF4L2 Gene

Post-translational modifications for MORF4L2 Gene

  • Ubiquitination at Lys49
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for MORF4L2 Gene

Domains & Families for MORF4L2 Gene

Gene Families for MORF4L2 Gene

Protein Domains for MORF4L2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MORF4L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MORF4L2: view

No data available for UniProtKB/Swiss-Prot for MORF4L2 Gene

Function for MORF4L2 Gene

Molecular function for MORF4L2 Gene

UniProtKB/Swiss-Prot Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.

Gene Ontology (GO) - Molecular Function for MORF4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11988016
genes like me logo Genes that share ontologies with MORF4L2: view
genes like me logo Genes that share phenotypes with MORF4L2: view

Animal Models for MORF4L2 Gene

MGI Knock Outs for MORF4L2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MORF4L2 Gene

Localization for MORF4L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MORF4L2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MORF4L2 gene
Compartment Confidence
nucleus 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for MORF4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 10942595
GO:0005886 plasma membrane IDA --
GO:0035267 NuA4 histone acetyltransferase complex IBA --
genes like me logo Genes that share ontologies with MORF4L2: view

Pathways & Interactions for MORF4L2 Gene

genes like me logo Genes that share pathways with MORF4L2: view

Pathways by source for MORF4L2 Gene

Gene Ontology (GO) - Biological Process for MORF4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006325 chromatin organization IEA --
GO:0006338 chromatin remodeling IBA --
GO:0006342 chromatin silencing IBA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MORF4L2: view

No data available for SIGNOR curated interactions for MORF4L2 Gene

Drugs & Compounds for MORF4L2 Gene

No Compound Related Data Available

Transcripts for MORF4L2 Gene

Unigene Clusters for MORF4L2 Gene

Mortality factor 4 like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MORF4L2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - -
SP17: - - - -
SP18: - - - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - -
SP20: - - - - -
SP21: - - - - - -
SP22: - - - - - - - - - - -
SP23: - - -
SP24: - - - - - - - -

ExUns: 7c · 7d · 7e · 7f · 7g · 7h · 7i · 7j · 7k · 7l · 7m · 7n · 7o · 7p
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:

Relevant External Links for MORF4L2 Gene

GeneLoc Exon Structure for
MORF4L2
ECgene alternative splicing isoforms for
MORF4L2

Expression for MORF4L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MORF4L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MORF4L2 Gene

This gene is overexpressed in Lung (35.7), Breast (9.9), and Adrenal (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MORF4L2 Gene



Protein tissue co-expression partners for MORF4L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MORF4L2 Gene:

MORF4L2

SOURCE GeneReport for Unigene cluster for MORF4L2 Gene:

Hs.326387

Evidence on tissue expression from TISSUES for MORF4L2 Gene

  • Nervous system(4.9)
  • Pancreas(4.6)
  • Bone marrow(4.3)
  • Lung(4.1)
  • Intestine(3.9)
  • Skin(3.9)
  • Kidney(3.5)
  • Liver(3.5)
  • Heart(2.7)
  • Adrenal gland(2.2)
  • Gall bladder(2.2)
  • Thyroid gland(2.2)
  • Eye(2)
  • Muscle(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with MORF4L2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MORF4L2 Gene

Orthologs for MORF4L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MORF4L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MORF4L2 34 35
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia MORF4L2 34 35
  • 95.83 (n)
cow
(Bos Taurus)
Mammalia MORF4L2 34 35
  • 90.36 (n)
rat
(Rattus norvegicus)
Mammalia Morf4l2 34
  • 88.43 (n)
mouse
(Mus musculus)
Mammalia Morf4l2 34 16 35
  • 87.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MORF4L2 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MORF4L2 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves MORF4L1 35
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 70 (a)
ManyToMany
-- 35
  • 69 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii morf4l1 35
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta MRG15 35
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mrg-1 35
  • 14 (a)
ManyToMany
cec-7 35
  • 9 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EAF3 35
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
Species where no ortholog for MORF4L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MORF4L2 Gene

ENSEMBL:
Gene Tree for MORF4L2 (if available)
TreeFam:
Gene Tree for MORF4L2 (if available)

Paralogs for MORF4L2 Gene

Paralogs for MORF4L2 Gene

(1) SIMAP similar genes for MORF4L2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for MORF4L2 Gene

genes like me logo Genes that share paralogs with MORF4L2: view

Variants for MORF4L2 Gene

Sequence variations from dbSNP and Humsavar for MORF4L2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000076182 -- 103,689,865(+) ATGGG(G/T)TTTCA intron-variant, upstream-variant-2KB
rs1000131845 -- 103,689,191(+) AAAAT(A/G)ATAAA nc-transcript-variant, upstream-variant-2KB
rs1000515063 -- 103,677,776(+) GACAA(A/T)TATAA intron-variant
rs1001132002 -- 103,686,707(+) AGCCA(A/G)GTTTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001336362 -- 103,686,396(+) TACGT(A/G)CCTTA intron-variant, upstream-variant-2KB

Variation tolerance for MORF4L2 Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MORF4L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MORF4L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MORF4L2 Gene

Disorders for MORF4L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MORF4L2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
paraneoplastic cerebellar degeneration
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MORF4L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MORF4L2
genes like me logo Genes that share disorders with MORF4L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MORF4L2 Gene

Publications for MORF4L2 Gene

  1. MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. (PMID: 14506250) Tominaga K. … Pereira-Smith O.M. (J. Biol. Chem. 2003) 3 4 22 64
  2. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PMID: 12963728) Cai Y. … Conaway J.W. (J. Biol. Chem. 2003) 3 4 22 64
  3. Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and transducin-like enhancer of Split. (PMID: 12391155) Yochum G.S. … Ayer D.E. (Mol. Cell. Biol. 2002) 3 4 22 64
  4. Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. (PMID: 9891081) Bertram M.J. … Pereira-Smith O.M. (Mol. Cell. Biol. 1999) 2 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4 64

Products for MORF4L2 Gene

Sources for MORF4L2 Gene

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