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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MORF4L2 Gene

protein-coding   GIFtS: 54
GCID: GC0XM102930

Mortality Factor 4 Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mortality Factor 4 Like 21 2     MORFL22 5
MRGX2 3 5     KIAA00263 5
Protein MSL3-22 3     MORF-Related Gene X1
Transcription Factor-Like Protein MRGX2 3     Mortality Factor 4-Like Protein 22
MORF-Related Gene X Protein2 3     MSL3-2 Protein2

External Ids:    HGNC: 168491   Entrez Gene: 96432   Ensembl: ENSG000001235627   OMIM: 3004095   UniProtKB: Q150143   

Export aliases for MORF4L2 gene to outside databases

Previous GC identifers: GC0XM099839 GC0XM100963 GC0XM101702 GC0XM102736 GC0XM102817 GC0XM092587


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MORF4L2 Gene: 
MORF4L2 (mortality factor 4 like 2) is a protein-coding gene. Diseases associated with MORF4L2 include cervix uteri carcinoma in situ, and paraneoplastic cerebellar degeneration. GO annotations related to this gene include protein binding. An important paralog of this gene is MORF4L1.

UniProtKB/Swiss-Prot: MO4L2_HUMAN, Q15014
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation
of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter
nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which
positively regulate transcription. This complex may be required for the activation of transcriptional programs
associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest
and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to
be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct
role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which
acts to repress transcription by deacetylation of nucleosomal histones

Gene Wiki entry for MORF4L2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MORF4L2 gene promoter:
         NF-1   CBF-B   CBF-A   SRF (504 AA)   CBF(2)   CBF-C   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MORF4L2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MORF4L2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MORF4L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22   Ensembl cytogenetic band:  Xq22.2   HGNC cytogenetic band: Xq22

MORF4L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORF4L2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM102930:  view genomic region     (about GC identifiers)

Start:
102,930,424 bp from pter      End:
102,943,086 bp from pter
Size:
12,663 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MO4L2_HUMAN, Q15014 (See protein sequence)
Recommended Name: Mortality factor 4-like protein 2  
Size: 288 amino acids; 32308 Da
Subunit: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60
and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin,
ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with
MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which
lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the
MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46.
Interacts with MRFAP1 and RB1. May also interact with one or more as yet undefined members of the TLE
(transducin-like enhancer of split) family of transcriptional repressors
Subcellular location: Nucleus
Secondary accessions: B3KP92 D3DXA5 Q567V0 Q8J026

Explore the universe of human proteins at neXtProt for MORF4L2: NX_Q15014

Explore proteomics data for MORF4L2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15014

  • MORF4L2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MORF4L2 Protein Expression
    REFSEQ proteins (16 alternative transcripts): 
    NP_001135890.1  NP_001135891.1  NP_001135892.1  NP_001135893.1  NP_001135894.1  NP_001135895.1  NP_001135896.1  NP_001135897.1  
    NP_001135898.1  NP_001135899.1  NP_001135900.1  NP_001135901.1  NP_001135902.1  NP_001135903.1  NP_001135904.1  NP_036418.1  

    ENSEMBL proteins: 
     ENSP00000353643   ENSP00000361703   ENSP00000391969   ENSP00000413664   ENSP00000393283  
     ENSP00000400938   ENSP00000408607   ENSP00000415476   ENSP00000394417   ENSP00000410532  
     ENSP00000416120  

    Human Recombinant Protein Products for MORF4L2: 
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    Novus Biologicals MORF4L2 Proteins
    Novus Biologicals MORF4L2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MORF4L2
    Cloud-Clone Corp. Proteins for MORF4L2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus IDA10942595

    MORF4L2 for ontologies           About GeneDecksing



    MORF4L2 Antibody Products: 
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    Novus Biologicals MORF4L2 Antibodies
    Abcam antibodies for MORF4L2
    Cloud-Clone Corp. Antibodies for MORF4L2 
    ThermoFisher Antibody for MORF4L2
    LSBio Antibodies in human, mouse, rat for MORF4L2 

    Assay Products for MORF4L2: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MORF4L2 
    Cloud-Clone Corp. CLIAs for MORF4L2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR008676 MRG
     IPR026541 MRG_dom

    Graphical View of Domain Structure for InterPro Entry Q15014

    ProtoNet protein and cluster: Q15014

    1 Blocks protein domain: IPB008676 MRG

    UniProtKB/Swiss-Prot: MO4L2_HUMAN, Q15014
    Similarity: Contains 1 MRG domain


    MORF4L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MO4L2_HUMAN, Q15014
    Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation
    of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter
    nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which
    positively regulate transcription. This complex may be required for the activation of transcriptional programs
    associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest
    and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to
    be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct
    role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which
    acts to repress transcription by deacetylation of nucleosomal histones

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11988016
         
    MORF4L2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MORF4L2:
     Synthetic lethal with c-Myc af 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Morf4l2):
     embryogenesis  growth/size  mortality/aging  normal 

    MORF4L2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Morf4l2tm1.1Kto for MORF4L2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MORF4L2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MORF4L2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MORF4L2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MORF4L2 

    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate MORF4L2 (see all 55):
    hsa-miR-4317 hsa-miR-3678-3p hsa-miR-323-3p hsa-miR-29a hsa-miR-105 hsa-miR-1276 hsa-miR-3658 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidMORF4L2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for MORF4L2
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 16): MORF4L2 (NM_001142418)
    Sino Biological Human cDNA Clone for MORF4L2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MORF4L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORF4L2
    Sirion Biotech Customized lentivirus for stable overexpression of MORF4L2 
                         Customized lentivirus expression plasmids for stable overexpression of MORF4L2 

    Cell Line
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    Search LifeMap BioReagents cell lines for MORF4L2
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORF4L2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MORF4L2

    5/638 Interacting proteins for MORF4L2 (Q150141, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 638)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MORF4L1Q9UBU82, 3MINT-7945693 MINT-8076071 I2D: score=1 
    RUVBL1Q9Y2652, 3MINT-7945693 MINT-8076071 I2D: score=1 
    RUVBL2Q9Y2302, 3MINT-7945693 MINT-8076071 I2D: score=1 
    HDAC1Q135472, 3MINT-7945693 I2D: score=4 
    ACTL6AO960192, 3MINT-7945693 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth NAS--
    GO:0006281DNA repair IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0016568chromatin modification IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    MORF4L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MORF4L2 (MO4L2)

    Search CenterWatch for drugs/clinical trials and news about MORF4L2 / MO4L2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MORF4L2 gene (16 alternative transcripts): 
    NM_001142418.1  NM_001142419.1  NM_001142420.1  NM_001142421.1  NM_001142422.1  NM_001142423.1  NM_001142424.1  NM_001142425.1  
    NM_001142426.1  NM_001142427.1  NM_001142428.1  NM_001142429.1  NM_001142430.1  NM_001142431.1  NM_001142432.1  NM_012286.2  

    Unigene Cluster for MORF4L2:

    Mortality factor 4 like 2
    Hs.326387  [show with all ESTs]
    Unigene Representative Sequence: BC035249
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360458 ENST00000372620 ENST00000441076 ENST00000434230 ENST00000418819
    ENST00000442614 ENST00000492116 ENST00000422355 ENST00000474653 ENST00000467755
    ENST00000498064 ENST00000488331 ENST00000433176(uc004elc.3 uc004ele.3 uc004elf.3 uc011msa.2 uc011msb.2 uc011msc.2 uc011msd.2 uc004eld.3)
    ENST00000422154(uc004elb.3 uc004ekx.3 uc004eky.3 uc010nos.3 uc004ekz.3 uc011mry.2 uc011mrz.2)
    ENST00000451301(uc004ela.3) ENST00000423833(uc004ekw.3)
    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate MORF4L2 (see all 55):
    hsa-miR-4317 hsa-miR-3678-3p hsa-miR-323-3p hsa-miR-29a hsa-miR-105 hsa-miR-1276 hsa-miR-3658 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidMORF4L2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MORF4L2
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    Additional mRNA sequence: 

    AB050778.1 AB050779.1 AF100620.1 AF167174.1 AK056012.1 AK095298.1 AK126115.1 AK126427.1 
    AK223504.1 AK302083.1 BC035249.1 BC050731.1 BC056899.1 BC093013.1 D14812.1 

    24/49 DOTS entries (see all 49):

    DT.87017524  DT.100888283  DT.100888281  DT.91831219  DT.101985584  DT.97794474  DT.92463009  DT.100888287 
    DT.100888302  DT.102837771  DT.92463014  DT.95105395  DT.121281302  DT.100888303  DT.100888289  DT.97855549 
    DT.95079818  DT.40116312  DT.95338171  DT.95105332  DT.40209820  DT.92463016  DT.121281189  DT.121281242 

    24/1092 AceView cDNA sequences (see all 1092):

    CR606527 CF141139 AI435512 CR592635 BM476805 AU107294 BU193002 CR606859 
    BQ432014 BQ228072 BE883263 BF034496 CR599214 AA115738 AI884357 AI610630 
    CR625600 BQ940031 AV726452 AA878284 CR621359 BF447542 CF144648 BQ423060 

    GeneLoc Exon Structure

    5/24 Alternative Splicing Database (ASD) splice patterns (SP) for MORF4L2 (see all 24)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ·
    SP1:                          -     -     -     -     -     -     -     -     -     -     -           -     -                                                   
    SP2:                          -     -     -     -     -     -     -     -     -     -     -           -     -           -     -                                 
    SP3:                                                                          -     -     -           -     -           -     -                                 
    SP4:                                                                          -     -     -           -     -                                                   
    SP5:                                                                          -     -     -           -     -           -                                       

    ExUns: 7c · 7d · 7e · 7f · 7g · 7h · 7i · 7j · 7k · 7l · 7m · 7n · 7o · 7p
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for MORF4L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MORF4L2 expression in normal human tissues (normalized intensities)      MORF4L2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGAGGCAA
    MORF4L2 Expression
    About this image


    MORF4L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad

    See MORF4L2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MORF4L2

    SOURCE GeneReport for Unigene cluster: Hs.326387
        SABiosciences Custom PCR Arrays for MORF4L2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MORF4L2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Morf4l21 , 5 mortality factor 4 like 21, 5 87.73(n)1
    95.14(a)1
      X (59.10 cM)5
    563971  NM_019768.41  NP_062742.41 
     1367329425 
    chicken
    (Gallus gallus)
    Aves MORF4L16
    mortality factor 4 like 1 isoform 1
    58(a)
    1 → many
    10(19142325-19164790)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    70(a)
    70(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    GL343392.1(127921-131583)
    GL343835.1(85152-90372)
    zebrafish
    (Danio rerio)
    Actinopterygii morf4l16
    mortality factor 4 like 1
    61(a)
    1 → many
    18(19814734-19826018)
    fruit fly
    (Drosophila melanogaster)
    Insecta MRG156
    MRG15
    25(a)
    1 → many
    3R(11102162-11103831)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EAF36
    Esa1p-associated factor, nonessential component of...
    18(a)
    1 → many
    XVI(608826-610031)


    ENSEMBL Gene Tree for MORF4L2 (if available)
    TreeFam Gene Tree for MORF4L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MORF4L2 gene
    MORF4L12  
    1 SIMAP similar gene for MORF4L2 using alignment to 6 protein entries:     MO4L2_HUMAN (see all proteins):
    MORF4L1

    MORF4L2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MORF4L2
    PGOHUM00000245911


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/153 SNPs in MORF4L2 are shown (see all 153)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs173425881,2
    C,F,H--102930301(+) TACATC/GATTCT 16 -- int113Minor allele frequency- N:0.00NA EA NS WA 1054
    rs1847334431,2
    --102930309(+) TCTTAC/TTTGCA 16 -- int10--------
    rs31791291,2
    C--102930429(-) TCAAAG/ACAAGT 16 -- ut311Minor allele frequency- A:0.00NA 2
    rs10645531,2
    C--102930667(-) TATGGT/GGCTTG 16 -- ut312Minor allele frequency- G:0.41MN NA 186
    rs589982501,2
    C--102930672(+) ACCAT-/AAAAAA 16 -- ut311Minor allele frequency- A:0.00CSA 2
    rs8741,2
    C,F,H--102930960(-) TGTTTT/CCCGTT 16 -- ut31 ese317Minor allele frequency- C:0.31MN NS EA NA 2328
    rs1891546781,2
    --102931006(+) TTAAAA/GAACAT 16 -- ut310--------
    rs1480094141,2
    F--102931304(+) CATTGG/CAGCAT 32 /P /A mis11Minor allele frequency- C:0.00NA 4550
    rs1997410091,2
    C--102931383(+) ATCACA/GTTGAA 32 N syn10--------
    rs1417167161,2
    C--102931422(+) TTAACC/TGCATA 32 A syn11Minor allele frequency- T:0.00NA 4536

    HapMap Linkage Disequilibrium report for MORF4L2 (102930424 - 102943086 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MORF4L2: --
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300409    OMIM disorders: --

    6 diseases for MORF4L2:    About MalaCards
    cervix uteri carcinoma in situ    paraneoplastic cerebellar degeneration    cerebellar degeneration    eaf
    gastric cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for MORF4L2:
    Cervix uteri carcinoma in situ

    MORF4L2 for disorders           About GeneDecksing


    Export disorders for MORF4L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MORF4L2 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with MORF4L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. (PubMed id 9891081)1, 2, 3 Bertram M.J.... Pereira-Smith O.M. (1999)
    2. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2, 3 Nomura N.... Tabata S. (1994)
    3. MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. (PubMed id 14506250)1, 2, 9 Tominaga K....Pereira-Smith O.M. (2003)
    4. Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and transducin-like enhancer of Split. (PubMed id 12391155)1, 2, 9 Yochum G.S. and Ayer D.E. (2002)
    5. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PubMed id 12963728)1, 2, 9 Cai Y.... Conaway J.W. (2003)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    10. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9643 HGNC: 16849 AceView: MORF4L2 Ensembl:ENSG00000123562 euGenes: HUgn9643
    ECgene: MORF4L2 H-InvDB: MORF4L2

    (According to HUGE)
    About This Section
    HUGE: KIAA0026

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MORF4L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MORF4L2 gene:
    Search GeneIP for patents involving MORF4L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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