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MORF4L2 Gene

protein-coding   GIFtS: 59
GCID: GC0XM102930

Mortality Factor 4 Like 2

  See MORF4L2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mortality Factor 4 Like 21 2     MORFL22 5
MRGX2 3 5     KIAA00263 5
Protein MSL3-22 3     MORF-Related Gene X1
Transcription Factor-Like Protein MRGX2 3     Mortality Factor 4-Like Protein 22
MORF-Related Gene X Protein2 3     MSL3-2 Protein2

External Ids:    HGNC: 168491   Entrez Gene: 96432   Ensembl: ENSG000001235627   OMIM: 3004095   UniProtKB: Q150143   

Export aliases for MORF4L2 gene to outside databases

Previous GC identifers: GC0XM099839 GC0XM100963 GC0XM101702 GC0XM102736 GC0XM102817 GC0XM092587


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MORF4L2 Gene:
MORF4L2 (mortality factor 4 like 2) is a protein-coding gene. Diseases associated with MORF4L2 include cervix uteri carcinoma in situ. An important paralog of this gene is MORF4L1.

UniProtKB/Swiss-Prot: MO4L2_HUMAN, Q15014
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation
of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter
nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which
positively regulate transcription. This complex may be required for the activation of transcriptional programs
associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest
and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to
be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct
role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which
acts to repress transcription by deacetylation of nucleosomal histones

Gene Wiki entry for MORF4L2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MORF4L2 gene promoter:
         NF-1   CBF-B   CBF-A   SRF (504 AA)   CBF(2)   CBF-C   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MORF4L2 promoter sequence
   Search Chromatin IP Primers for MORF4L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MORF4L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22   Ensembl cytogenetic band:  Xq22.2   HGNC cytogenetic band: Xq22

MORF4L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORF4L2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM102930:  view genomic region     (about GC identifiers)

Start:
102,930,424 bp from pter      End:
102,943,086 bp from pter
Size:
12,663 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MO4L2_HUMAN, Q15014 (See protein sequence)
Recommended Name: Mortality factor 4-like protein 2  
Size: 288 amino acids; 32308 Da
Subunit: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60
and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin,
ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with
MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which
lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the
MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46.
Interacts with MRFAP1 and RB1. May also interact with one or more as yet undefined members of the TLE
(transducin-like enhancer of split) family of transcriptional repressors
Secondary accessions: B3KP92 D3DXA5 Q567V0 Q8J026

Explore the universe of human proteins at neXtProt for MORF4L2: NX_Q15014

Explore proteomics data for MORF4L2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys49
  • Modification sites at PhosphoSitePlus

  • See MORF4L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (16 alternative transcripts): 
    NP_001135890.1  NP_001135891.1  NP_001135892.1  NP_001135893.1  NP_001135894.1  NP_001135895.1  NP_001135896.1  NP_001135897.1  
    NP_001135898.1  NP_001135899.1  NP_001135900.1  NP_001135901.1  NP_001135902.1  NP_001135903.1  NP_001135904.1  NP_036418.1  

    ENSEMBL proteins: 
     ENSP00000353643   ENSP00000391969   ENSP00000413664   ENSP00000393283   ENSP00000400938  
     ENSP00000408607   ENSP00000415476   ENSP00000394417   ENSP00000410532   ENSP00000416120  
    Reactome Protein details: Q15014

    MORF4L2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals MORF4L2 Proteins
    Novus Biologicals MORF4L2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MORF4L2
    Cloud-Clone Corp. Proteins for MORF4L2

     
    Search eBioscience for Proteins for MORF4L2 

    MORF4L2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    OriGene Custom Antibody Services for MORF4L2
    Novus Biologicals MORF4L2 Antibodies
    Abcam antibodies for MORF4L2 (Q5JXX4, Q15014)
    Cloud-Clone Corp. Antibodies for MORF4L2
    ThermoFisher Antibody for MORF4L2
    LSBio Antibodies in human, mouse, rat for MORF4L2

    MORF4L2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MORF4L2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MORF4L2
    Cloud-Clone Corp. CLIAs for MORF4L2
    Search eBioscience for ELISAs for MORF4L2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008676 MRG
     IPR026541 MRG_dom

    Graphical View of Domain Structure for InterPro Entry Q15014

    ProtoNet protein and cluster: Q15014

    1 Blocks protein domain: IPB008676 MRG

    UniProtKB/Swiss-Prot: MO4L2_HUMAN, Q15014
    Similarity: Contains 1 MRG domain


    Find genes that share domains with MORF4L2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MO4L2_HUMAN, Q15014
    Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation
    of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter
    nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which
    positively regulate transcription. This complex may be required for the activation of transcriptional programs
    associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest
    and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to
    be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct
    role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which
    acts to repress transcription by deacetylation of nucleosomal histones

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11988016
         
    Find genes that share ontologies with MORF4L2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MORF4L2:
     Synthetic lethal with c-Myc af 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Morf4l2):
     embryogenesis  growth/size/body  mortality/aging  normal 

    Find genes that share phenotypes with MORF4L2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Morf4l2tm1.1Kto for MORF4L2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MORF4L2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MORF4L2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MORF4L2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MORF4L2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MORF4L2:
    hsa-mir-100-5p (MIRT048476), hsa-mir-142-3p (MIRT021637), hsa-mir-20a-5p (MIRT050589), hsa-mir-652-3p (MIRT039553), hsa-mir-17-5p (MIRT050967), hsa-mir-505-3p (MIRT041000)

    Block miRNA regulation of human, mouse, rat MORF4L2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MORF4L2 (see all 55):
    hsa-miR-4317 hsa-miR-3678-3p hsa-miR-323-3p hsa-miR-29a hsa-miR-105 hsa-miR-1276 hsa-miR-3658 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidMORF4L2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MORF4L2
    Predesigned siRNA for gene silencing in human, mouse, rat MORF4L2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MORF4L2

    Clone
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    OriGene clones in human, mouse for MORF4L2 (see all 92)
    OriGene ORF clones in mouse, rat for MORF4L2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 16): MORF4L2 (NM_001142418)
    Sino Biological Human cDNA Clone for MORF4L2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MORF4L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORF4L2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MORF4L2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MORF4L2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORF4L2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MO4L2_HUMAN, Q15014: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with MORF4L2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MORF4L2 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34


    Find genes that share SuperPaths with MORF4L2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for MORF4L2
        HATs acetylate histones


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MORF4L2
    Interactions:

        GeneGlobe Interaction Network for MORF4L2

    Selected Interacting proteins for MORF4L2 (Q150141, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 637)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MORF4L1Q9UBU82, 3MINT-7945693 MINT-8076071 I2D: score=1 
    RUVBL1Q9Y2652, 3MINT-7945693 MINT-8076071 I2D: score=1 
    RUVBL2Q9Y2302, 3MINT-7945693 MINT-8076071 I2D: score=1 
    HDAC1Q135472, 3MINT-7945693 I2D: score=4 
    ACTL6AO960192, 3MINT-7945693 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth ----
    GO:0006281DNA repair IEA--
    GO:0006325chromatin organization TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0016568chromatin modification IEA--

    Find genes that share ontologies with MORF4L2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MORF4L2 (MO4L2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MORF4L2 gene (16 alternative transcripts): 
    NM_001142418.1  NM_001142419.1  NM_001142420.1  NM_001142421.1  NM_001142422.1  NM_001142423.1  NM_001142424.1  NM_001142425.1  
    NM_001142426.1  NM_001142427.1  NM_001142428.1  NM_001142429.1  NM_001142430.1  NM_001142431.1  NM_001142432.1  NM_012286.2  

    Unigene Cluster for MORF4L2:

    Mortality factor 4 like 2
    Hs.326387  [show with all ESTs]
    Unigene Representative Sequence: BC035249
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360458 ENST00000441076 ENST00000434230 ENST00000418819 ENST00000442614
    ENST00000492116 ENST00000422355 ENST00000474653 ENST00000467755 ENST00000498064
    ENST00000488331 ENST00000433176(uc004elc.3 uc004ele.3 uc004elf.3 uc011msa.2 uc011msb.2 uc011msc.2 uc011msd.2 uc004eld.3)
    ENST00000422154(uc004elb.3 uc004ekx.3 uc004eky.3 uc010nos.3 uc004ekz.3 uc011mry.2 uc011mrz.2)
    ENST00000451301(uc004ela.3) ENST00000423833(uc004ekw.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat MORF4L2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MORF4L2 (see all 55):
    hsa-miR-4317 hsa-miR-3678-3p hsa-miR-323-3p hsa-miR-29a hsa-miR-105 hsa-miR-1276 hsa-miR-3658 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidMORF4L2 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 16): MORF4L2 (NM_001142418)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORF4L2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MORF4L2
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      QuantiTect SYBR Green Assays in human, mouse, rat MORF4L2
      QuantiFast Probe-based Assays in human, mouse, rat MORF4L2

    Additional mRNA sequence: 

    AB050778.1 AB050779.1 AF100620.1 AF167174.1 AK056012.1 AK095298.1 AK126115.1 AK126427.1 
    AK223504.1 AK302083.1 BC035249.1 BC050731.1 BC056899.1 BC093013.1 D14812.1 

    Selected DOTS entries (see all 49):

    DT.87017524  DT.100888283  DT.100888281  DT.91831219  DT.101985584  DT.97794474  DT.92463009  DT.100888287 
    DT.100888302  DT.102837771  DT.92463014  DT.95105395  DT.121281302  DT.100888303  DT.100888289  DT.97855549 
    DT.95079818  DT.40116312  DT.95338171  DT.95105332  DT.40209820  DT.92463016  DT.121281189  DT.121281242 

    Selected AceView cDNA sequences (see all 1092):

    CR625600 BQ421899 AI884357 CB144155 BQ940031 BG166115 BU741317 BP343293 
    AA580303 AI700608 AL542010 BQ878235 BQ420320 BM469132 BQ889460 AA309095 
    AI202482 AW073756 AU107287 CR599829 D14812 CA952438 CF141661 BQ722011 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MORF4L2 (see all 24)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ·
    SP1:                          -     -     -     -     -     -     -     -     -     -     -           -     -                                                   
    SP2:                          -     -     -     -     -     -     -     -     -     -     -           -     -           -     -                                 
    SP3:                                                                          -     -     -           -     -           -     -                                 
    SP4:                                                                          -     -     -           -     -                                                   
    SP5:                                                                          -     -     -           -     -           -                                       

    ExUns: 7c · 7d · 7e · 7f · 7g · 7h · 7i · 7j · 7k · 7l · 7m · 7n · 7o · 7p
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for MORF4L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MORF4L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGAGGCAA
    MORF4L2 Expression
    About this image


    MORF4L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    MORF4L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MORF4L2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.326387
        Custom PCR Arrays for MORF4L2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MORF4L2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Morf4l21 , 5 mortality factor 4 like 21, 5 87.73(n)1
    95.14(a)1
      X (59.10 cM)5
    563971  NM_001168226.11  NP_001161698.11 
     1367329425 
    chicken
    (Gallus gallus)
    Aves MORF4L16
    Gallus gallus mortality factor 4 like 1 (MORF4L1),...
    51(a)
    1 → many
    10(19142325-19164790)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    70(a)
    69(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343835.1(85152-90372)
    GL343392.1(127921-131583)
    zebrafish
    (Danio rerio)
    Actinopterygii morf4l16
    mortality factor 4 like 1
    53(a)
    1 → many
    18(19814734-19826018) ENSDARG00000041155
    fruit fly
    (Drosophila melanogaster)
    Insecta MRG156
    MRG15
    25(a)
    1 → many
    3R(11102162-11103831)
    worm
    (Caenorhabditis elegans)
    Secernentea cec-76
    mrg-16
    Protein CEC-7, isoform a (cec-7) mRNA, complete cd...
    Protein MRG-1, isoform a (mrg-1) mRNA, complete cd...
    9(a)
    14(a)
    many ↔ many
    many ↔ many
    III(12875206-12877577) WBGene00012551
    III(12871268-12874654) WBGene00003406
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EAF36
    Esa1p-associated factor, nonessential component of...
    12(a)
    1 → many
    XVI(608826-610031) YPR023C


    ENSEMBL Gene Tree for MORF4L2 (if available)
    TreeFam Gene Tree for MORF4L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MORF4L2 gene
    MORF4L12  
    1 SIMAP similar gene for MORF4L2 using alignment to 5 protein entries:     MO4L2_HUMAN (see all proteins):
    MORF4L1

    Find genes that share paralogs with MORF4L2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MORF4L2
    PGOHUM00000245911


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MORF4L2 (see all 153)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs173425881,2
    C,F,H--102930301(+) TACATC/GATTCT 16 -- int113Minor allele frequency- N:0.00NA EA NS WA 1054
    rs1847334431,2
    --102930309(+) TCTTAC/TTTGCA 16 -- int10--------
    rs31791291,2
    C--102930429(-) TCAAAG/ACAAGT 16 -- ut311Minor allele frequency- A:0.00NA 2
    rs10645531,2
    C--102930667(-) TATGGT/GGCTTG 16 -- ut312Minor allele frequency- G:0.41MN NA 186
    rs589982501,2
    C--102930672(+) ACCAT-/AAAAAA 16 -- ut311Minor allele frequency- A:0.00CSA 2
    rs8741,2
    C,F,H--102930960(-) TGTTTT/CCCGTT 16 -- ut31 ese317Minor allele frequency- C:0.31MN NS EA NA 2328
    rs1891546781,2
    --102931006(+) TTAAAA/GAACAT 16 -- ut310--------
    rs1480094141,2
    F--102931304(+) CATTGG/CAGCAT 32 /P /A mis11Minor allele frequency- C:0.00NA 4550
    rs1997410091,2
    C--102931383(+) ATCACA/GTTGAA 32 N syn10--------
    rs1417167161,2
    C--102931422(+) TTAACC/TGCATA 32 A syn11Minor allele frequency- T:0.00NA 4536

    HapMap Linkage Disequilibrium report for MORF4L2 (102930424 - 102943086 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MORF4L2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MORF4L2
    DNA2.0 Custom Variant and Variant Library Synthesis for MORF4L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300409    OMIM disorders: --

    1 disease for MORF4L2:    
    About MalaCards
    cervix uteri carcinoma in situ

    1 disease from the University of Copenhagen DISEASES database for MORF4L2:
    Cervix uteri carcinoma in situ

    Find genes that share disorders with MORF4L2           About GenesLikeMe


    Export disorders for MORF4L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MORF4L2 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with MORF4L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. (PubMed id 9891081)1, 2, 3 Bertram M.J.... Pereira-Smith O.M. (Mol. Cell. Biol. 1999)
    2. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2, 3 Nomura N.... Tabata S. (DNA Res. 1994)
    3. MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. (PubMed id 14506250)1, 2, 9 Tominaga K....Pereira-Smith O.M. (J. Biol. Chem. 2003)
    4. Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and transducin-like enhancer of Split. (PubMed id 12391155)1, 2, 9 Yochum G.S. and Ayer D.E. (Mol. Cell. Biol. 2002)
    5. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PubMed id 12963728)1, 2, 9 Cai Y.... Conaway J.W. (J. Biol. Chem. 2003)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9643 HGNC: 16849 AceView: MORF4L2 Ensembl:ENSG00000123562 euGenes: HUgn9643
    ECgene: MORF4L2 H-InvDB: MORF4L2

    (According to HUGE)
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    HUGE: KIAA0026

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MORF4L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MORF4L2 gene:
    Search GeneIP for patents involving MORF4L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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