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MORF4L1 Gene

protein-coding   GIFtS: 57
GCID: GC15P079102

Mortality Factor 4 Like 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mortality Factor 4 Like 11 2     Eaf32
MRG152 3 5     HsT177252
MORF-Related Gene On Chromosome 151 2     MEAF32
Protein MSL3-12 3     MORFRG152
Transcription Factor-Like Protein MRG152 3     S863-62
MORF-Related Gene 15 Protein2 3     Esa1p-Associated Factor 3 Homolog2
Esa1p-Associated Factor 3 Homolog (S. Cerevisiae)1     Mortality Factor 4-Like Protein 12

External Ids:    HGNC: 169891   Entrez Gene: 109332   Ensembl: ENSG000001857877   OMIM: 6073035   UniProtKB: Q9UBU83   

Export aliases for MORF4L1 gene to outside databases

Previous GC identifers: GC15P072322 GC15P076678 GC15P076881 GC15P076952 GC15P079132


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MORF4L1 Gene:
MORF4L1 (mortality factor 4 like 1) is a protein-coding gene. GO annotations related to this gene include chromatin binding and protein N-terminus binding. An important paralog of this gene is MORF4L2.

UniProtKB/Swiss-Prot: MO4L1_HUMAN, Q9UBU8
Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional
activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may
both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins
which positively regulate transcription. This complex may be required for the activation of transcriptional
programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth
arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities
seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play
a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex
which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous
recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and
RAD51, but not BRCA1, to DNA-damage foci

Gene Wiki entry for MORF4L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MORF4L1 gene promoter:
         Spz1   p53   Ik-3   FOXC1   POU2F1   POU2F1a   Zic1   ARP-1   ATF   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMORF4L1 promoter sequence
   Search Chromatin IP Primers for MORF4L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MORF4L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q25.1

MORF4L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORF4L1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P079102:  view genomic region     (about GC identifiers)

Start:
79,102,829 bp from pter      End:
79,190,475 bp from pter
Size:
87,647 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MO4L1_HUMAN, Q9UBU8 (See protein sequence)
Recommended Name: Mortality factor 4-like protein 1  
Size: 362 amino acids; 41474 Da
Subunit: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60
and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin,
ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts
with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes
which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of
the mSin3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and
RBBP7/RbAp46. Interacts with RB1 and KAT8. May also interact with PHF12 and one or more as yet undefined members
of the TLE (transducin-like enhancer of split) family of transcriptional repressors. Interacts with the
N-terminus of MRFAP1. Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts with the entire BRCA
complex, which contains BRCA1, PALB2, BRCA2 and RAD51. Interacts with PALB2. Forms a complex with MSL1 and NUPR1
Sequence caution: Sequence=AAG17253.1; Type=Frameshift; Positions=348, 360;
5 PDB 3D structures from and Proteopedia for MORF4L1:
2AQL (3D)        2EFI (3D)        2F5J (3D)        2F5K (3D)        2LKM (3D)    
Secondary accessions: B4DKN6 B7Z6R1 D3DW88 O95899 Q5QTS1 Q6NVX8 Q86YT7 Q9HBP6 Q9NSW5
Alternative splicing: 3 isoforms:  Q9UBU8-1   Q9UBU8-2   Q9UBU8-3   

Explore the universe of human proteins at neXtProt for MORF4L1: NX_Q9UBU8

Explore proteomics data for MORF4L1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys103, Lys111, Lys117, Lys127, Lys143, Lys198, Lys218, Lys226, Lys240, Lys241,
                                 Lys249, Lys339
  • Modification sites at PhosphoSitePlus

  • See MORF4L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001252532.1  NP_001252533.1  NP_001252534.1  NP_006782.1  NP_996670.1  

    ENSEMBL proteins: 
     ENSP00000368850   ENSP00000408880   ENSP00000331310   ENSP00000454191   ENSP00000453231  
     ENSP00000453738   ENSP00000452717   ENSP00000452808   ENSP00000453351   ENSP00000453432  
     ENSP00000453625   ENSP00000454030   ENSP00000453972  
    Reactome Protein details: Q9UBU8

    MORF4L1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MORF4L1

     
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    MORF4L1 Antibody Products:

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    Abcam antibodies for MORF4L1
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    LSBio Antibodies in human, mouse, rat for MORF4L1

    MORF4L1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MORF4L1
    Cloud-Clone Corp. CLIAs for MORF4L1
    Search eBioscience for ELISAs for MORF4L1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR008676 MRG
     IPR026541 MRG_dom
     IPR016197 Chromodomain-like
     IPR025995 Tudor-knot
     IPR017398 EAF3/MRG15

    Graphical View of Domain Structure for InterPro Entry Q9UBU8

    ProtoNet protein and cluster: Q9UBU8

    2 Blocks protein domains:
    IPB000953 Chromo domain
    IPB008676 MRG


    UniProtKB/Swiss-Prot: MO4L1_HUMAN, Q9UBU8
    Similarity: Contains 1 MRG domain


    Find genes that share domains with MORF4L1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MO4L1_HUMAN, Q9UBU8
    Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional
    activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may
    both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins
    which positively regulate transcription. This complex may be required for the activation of transcriptional
    programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth
    arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities
    seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play
    a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex
    which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous
    recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and
    RAD51, but not BRCA1, to DNA-damage foci

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI14506250
    GO:0047485protein N-terminus binding IPI17577209
         
    Find genes that share ontologies with MORF4L1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MORF4L1:
     Increased number of cells in m 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Morf4l1):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     respiratory system 

    Find genes that share phenotypes with MORF4L1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Morf4l1tm1Kto for MORF4L1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MORF4L1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MORF4L1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MORF4L1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MORF4L1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MORF4L1:
    hsa-mir-222-3p (MIRT046737), hsa-mir-142-3p (MIRT021617), hsa-mir-9-5p (MIRT021448), hsa-mir-615-3p (MIRT039724), hsa-mir-16-5p (MIRT032039), hsa-mir-29c-3p (MIRT020406), hsa-mir-148b-3p (MIRT019410)

    Block miRNA regulation of human, mouse, rat MORF4L1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MORF4L1 (see all 31):
    hsa-miR-124* hsa-miR-142-3p hsa-miR-1226 hsa-miR-495 hsa-miR-106a hsa-miR-1271 hsa-miR-517b hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidMORF4L1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat MORF4L1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): MORF4L1 (NM_006791)
    Sino Biological Human cDNA Clone for MORF4L1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MORF4L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORF4L1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORF4L1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MO4L1_HUMAN, Q9UBU8: Nucleus

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0016580Sin3 complex IDA14966270
    GO:0035267NuA4 histone acetyltransferase complex IDA14966270

    Find genes that share ontologies with MORF4L1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MORF4L1 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34
    2Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with MORF4L1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MORF4L1
        Chromatin Regulation / Acetylation


    1 Reactome Pathway for MORF4L1
        HATs acetylate histones


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MORF4L1
    Interactions:

        GeneGlobe Interaction Network for MORF4L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MORF4L1 (Q9UBU82, 3 ENSP000003313104) via UniProtKB, MINT, STRING, and/or I2D (see all 906)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST1H4CP628053, ENSP000003670344I2D: score=2 STRING: ENSP00000367034
    HIST1H4DP628053, ENSP000003432824I2D: score=2 STRING: ENSP00000343282
    HIST1H4EP628053, ENSP000003536244I2D: score=2 STRING: ENSP00000353624
    HIST1H4HP628053, ENSP000002893524I2D: score=2 STRING: ENSP00000289352
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination IDA--
    GO:0006325chromatin organization TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0008283cell proliferation IEA--

    Find genes that share ontologies with MORF4L1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MORF4L1 (MO4L1)

    1 Novoseek inferred chemical compound relationship for MORF4L1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 26.1 4 11500496 (2), 12397079 (1)



    Find genes that share compounds with MORF4L1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MORF4L1 gene (5 alternative transcripts): 
    NM_001265603.1  NM_001265604.1  NM_001265605.1  NM_006791.3  NM_206839.2  

    Unigene Cluster for MORF4L1:

    Mortality factor 4 like 1
    Hs.374503  [show with all ESTs]
    Unigene Representative Sequence: NM_206839
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000379535 ENST00000559697 ENST00000426013(uc002bem.3 uc010une.2)
    ENST00000331268(uc002bel.3) ENST00000557961 ENST00000559930 ENST00000558746
    ENST00000558893(uc010blj.1) ENST00000558830 ENST00000558522(uc010bli.1)
    ENST00000559619 ENST00000559345 ENST00000561171 ENST00000558502 ENST00000559258
    ENST00000559690 ENST00000559158 ENST00000560422
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    Selected qRT-PCR Assays for microRNAs that regulate MORF4L1 (see all 31):
    hsa-miR-124* hsa-miR-142-3p hsa-miR-1226 hsa-miR-495 hsa-miR-106a hsa-miR-1271 hsa-miR-517b hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidMORF4L1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MORF4L1
      QuantiFast Probe-based Assays in human, mouse, rat MORF4L1

    Additional mRNA sequence: 

    AF070664.1 AF100615.1 AF109188.1 AF131847.1 AF161546.1 AF167173.1 AF218011.1 AK098485.1 
    AK296650.1 AK300789.1 AK310702.1 AL137697.1 AY148481.1 BC002936.2 BC022845.2 BC067826.1 
    BC121092.1 BC121093.1 BC141840.1 

    Selected DOTS entries (see all 56):

    DT.100722399  DT.100891602  DT.100891590  DT.100891587  DT.100891561  DT.91784109  DT.100891566  DT.102838436 
    DT.121068697  DT.95341884  DT.100891585  DT.95164056  DT.100891599  DT.100891605  DT.95164037  DT.97809450 
    DT.100891606  DT.121336510  DT.100891578  DT.100891584  DT.100891595  DT.121336540  DT.95294104  DT.100891592 

    Selected AceView cDNA sequences (see all 1004):

    W78205 AA039813 CA412864 BQ069274 BQ921679 BM556610 BU187949 T08274 
    BX281371 AA875881 AW273394 BM550693 BE907020 N42881 CD243861 AW771715 
    AY148481 AA081760 BQ230045 BU634339 BG575515 W51928 F37070 BM565616 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MORF4L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGACGCAA
    MORF4L1 Expression
    About this image


    MORF4L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule
    MORF4L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MORF4L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.374503
        Custom PCR Arrays for MORF4L1
    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MORF4L1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Morf4l11 , 5 mortality factor 4 like 11, 5 91.62(n)1
    99.72(a)1
      9 (47.42 cM)5
    217611  NM_001039147.21  NP_001034236.11 
     900916715 
    chicken
    (Gallus gallus)
    Aves MORF4L16
    Gallus gallus mortality factor 4 like 1 (MORF4L1),...
    86(a)
    1 → many
    10(19142325-19164790)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    65(a)
    62(a)
    many ↔ many
    many ↔ many
    GL343835.1(85152-90372)
    GL343392.1(127921-131583)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA973721.12   -- 81.47(n)    CA973721.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.139502 Transcribed sequence with moderate similarity to protein more 81.34(n)    CA472651.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MRG156
    MRG15
    37(a)
    1 → many
    3R(11102162-11103831)
    worm
    (Caenorhabditis elegans)
    Secernentea mrg-11 mrg-1 45.66(n)
    33.45(a)
      176702  NM_067274.3  NP_499675.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EAF3(YPR023C)4 Esa1p-associated factor, nonessential component of more   --   16(610031-608826) 856134  NP_015348.1 


    ENSEMBL Gene Tree for MORF4L1 (if available)
    TreeFam Gene Tree for MORF4L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MORF4L1 gene
    MORF4L22  
    1 SIMAP similar gene for MORF4L1 using alignment to 12 protein entries:     MO4L1_HUMAN (see all proteins):
    MORF4L2

    Find genes that share paralogs with MORF4L1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for MORF4L1 (see all 9)
    PGOHUM00000242175 PGOHUM00000239350 PGOHUM00000248380 PGOHUM00000244349 PGOHUM00000245210


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MORF4L1 (see all 802)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1396235071,2
    --79163171(+) TGGTGG/TGGTGG 3 -- us2k10--------
    rs747374301,2
    C--79163284(+) AGCCCC/TTTCCT 3 -- us2k10--------
    rs745453381,2
    C--79163331(+) TAAAAA/TCCATG 5 -- us2k10--------
    rs1893527421,2
    --79163394(+) AGACAG/TGTTGG 5 -- us2k10--------
    rs1476708251,2
    C--79163399(+) GGTTGA/GACAAG 5 -- us2k10--------
    rs1821930261,2
    --79163532(+) TAAATA/GGAGAG 5 -- us2k10--------
    rs1423260311,2
    --79163549(+) GGAATC/TGGTGG 5 -- us2k10--------
    rs1466015781,2
    --79163556(+) GTGGGG/TTGTGG 5 -- us2k10--------
    rs734776631,2
    C--79163565(+) GGAACC/GCGGGC 5 -- us2k12Minor allele frequency- G:0.05WA 120
    rs47787381,2
    C,F,A,H--79163602(+) GACAGA/GCTGGG 5 -- us2k110Minor allele frequency- G:0.45NA WA CSA EA 372

    HapMap Linkage Disequilibrium report for MORF4L1 (79102829 - 79190475 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MORF4L1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522996CNV Loss19592680
    nsv904432CNV Loss21882294
    esv33573CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607303    OMIM disorders: --


    Find genes that share disorders with MORF4L1           About GenesLikeMe

    2 Novoseek inferred disease relationships for MORF4L1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 46 3 11500496 (2), 17008723 (1)
    tumors 0 2 17008723 (1), 11500496 (1)

    Genetic Association Database (GAD): MORF4L1
    Human Genome Epidemiology (HuGE) Navigator: MORF4L1 (2 documents)

    Export disorders for MORF4L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MORF4L1 gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with MORF4L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. (PubMed id 12397079)1, 2, 9 Pardo P.S.... Pereira-Smith O.M. (J. Biol. Chem. 2002)
    2. MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14. (PubMed id 11500496)1, 2, 9 Leung J.K....Pereira-Smith O.M. (J. Biol. Chem. 2001)
    3. Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and transducin-like enhancer of Split. (PubMed id 12391155)1, 2, 9 Yochum G.S. and Ayer D.E. (Mol. Cell. Biol. 2002)
    4. The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14. (PubMed id 17008723)1, 2, 9 Zhang P.... Ding J. (Protein Sci. 2006)
    5. MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks. (PubMed id 20332121)1, 2, 9 Hayakawa T.... Andreassen P.R. (J. Cell Sci. 2010)
    6. Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain. (PubMed id 16407074)1, 2, 9 Bowman B.R.... Quiocho F.A. (Structure 2006)
    7. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PubMed id 12963728)1, 2, 9 Cai Y.... Conaway J.W. (J. Biol. Chem. 2003)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10933 HGNC: 16989 AceView: MORF4L1 Ensembl:ENSG00000185787 euGenes: HUgn10933
    ECgene: MORF4L1 H-InvDB: MORF4L1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MORF4L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MORF4L1 gene:
    Search GeneIP for patents involving MORF4L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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