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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MORF4L1 Gene

protein-coding   GIFtS: 55
GCID: GC15P079102

Mortality Factor 4 Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mortality Factor 4 Like 11 2     Eaf32
MRG152 3 5     HsT177252
MORF-Related Gene On Chromosome 151 2     MEAF32
Protein MSL3-12 3     MORFRG152
Transcription Factor-Like Protein MRG152 3     S863-62
MORF-Related Gene 15 Protein2 3     Esa1p-Associated Factor 3 Homolog2
Esa1p-Associated Factor 3 Homolog (S. Cerevisiae)1     Mortality Factor 4-Like Protein 12

External Ids:    HGNC: 169891   Entrez Gene: 109332   Ensembl: ENSG000001857877   OMIM: 6073035   UniProtKB: Q9UBU83   

Export aliases for MORF4L1 gene to outside databases

Previous GC identifers: GC15P072322 GC15P076678 GC15P076881 GC15P076952 GC15P079132


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MORF4L1 Gene: 
MORF4L1 (mortality factor 4 like 1) is a protein-coding gene. Diseases associated with MORF4L1 include paraneoplastic cerebellar degeneration, and cerebellar degeneration. GO annotations related to this gene include protein binding and protein N-terminus binding. An important paralog of this gene is MORF4L2.

UniProtKB/Swiss-Prot: MO4L1_HUMAN, Q9UBU8
Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional
activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may
both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins
which positively regulate transcription. This complex may be required for the activation of transcriptional
programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth
arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities
seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play
a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex
which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous
recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and
RAD51, but not BRCA1, to DNA-damage foci

Gene Wiki entry for MORF4L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MORF4L1 gene promoter:
         Spz1   p53   Ik-3   FOXC1   POU2F1   POU2F1a   Zic1   ARP-1   ATF   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMORF4L1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MORF4L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MORF4L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q25.1

MORF4L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORF4L1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P079102:  view genomic region     (about GC identifiers)

Start:
79,102,829 bp from pter      End:
79,190,475 bp from pter
Size:
87,647 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MO4L1_HUMAN, Q9UBU8 (See protein sequence)
Recommended Name: Mortality factor 4-like protein 1  
Size: 362 amino acids; 41474 Da
Subunit: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60
and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin,
ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts
with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes
which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of
the mSin3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and
RBBP7/RbAp46. Interacts with RB1 and KAT8. May also interact with PHF12 and one or more as yet undefined members
of the TLE (transducin-like enhancer of split) family of transcriptional repressors. Interacts with the
N-terminus of MRFAP1. Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts with the entire BRCA
complex, which contains BRCA1, PALB2, BRCA2 and RAD51. Interacts with PALB2. Forms a complex with MSL1 and NUPR1
Subcellular location: Nucleus
Sequence caution: Sequence=AAG17253.1; Type=Frameshift; Positions=348, 360;
5 PDB 3D structures from and Proteopedia for MORF4L1:
2AQL (3D)        2EFI (3D)        2F5J (3D)        2F5K (3D)        2LKM (3D)    
Secondary accessions: B4DKN6 B7Z6R1 D3DW88 O95899 Q5QTS1 Q6NVX8 Q86YT7 Q9HBP6 Q9NSW5
Alternative splicing: 3 isoforms:  Q9UBU8-1   Q9UBU8-2   Q9UBU8-3   

Explore the universe of human proteins at neXtProt for MORF4L1: NX_Q9UBU8

Explore proteomics data for MORF4L1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBU8

  • MORF4L1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MORF4L1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001252532.1  NP_001252533.1  NP_001252534.1  NP_006782.1  NP_996670.1  

    ENSEMBL proteins: 
     ENSP00000368850   ENSP00000408880   ENSP00000331310   ENSP00000454191   ENSP00000453231  
     ENSP00000453738   ENSP00000452717   ENSP00000452808   ENSP00000453351   ENSP00000453432  
     ENSP00000453625   ENSP00000454030   ENSP00000453972  

    Human Recombinant Protein Products for MORF4L1: 
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    Cloud-Clone Corp. Proteins for MORF4L1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0016580Sin3 complex IDA14966270
    GO:0035267NuA4 histone acetyltransferase complex IDA14966270

    MORF4L1 for ontologies           About GeneDecksing



    MORF4L1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR008676 MRG
     IPR026541 MRG_dom
     IPR016197 Chromodomain-like
     IPR025995 Tudor-knot
     IPR017398 EAF3/MRG15

    Graphical View of Domain Structure for InterPro Entry Q9UBU8

    ProtoNet protein and cluster: Q9UBU8

    2 Blocks protein domains:
    IPB000953 Chromo domain
    IPB008676 MRG


    UniProtKB/Swiss-Prot: MO4L1_HUMAN, Q9UBU8
    Similarity: Contains 1 MRG domain


    MORF4L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MO4L1_HUMAN, Q9UBU8
    Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional
    activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may
    both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins
    which positively regulate transcription. This complex may be required for the activation of transcriptional
    programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth
    arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities
    seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play
    a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex
    which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous
    recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and
    RAD51, but not BRCA1, to DNA-damage foci

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI14506250
    GO:0047485protein N-terminus binding IPI17577209
         
    MORF4L1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MORF4L1:
     Increased number of cells in m 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Morf4l1):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     respiratory system 

    MORF4L1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Morf4l1tm1Kto for MORF4L1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MORF4L1 
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    miRNA
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    hsa-miR-124* hsa-miR-142-3p hsa-miR-1226 hsa-miR-495 hsa-miR-106a hsa-miR-1271 hsa-miR-517b hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidMORF4L1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORF4L1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MORF4L1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MORF4L1
        Chromatin Regulation / Acetylation



    MORF4L1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MORF4L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/777 Interacting proteins for MORF4L1 (Q9UBU82, 3 ENSP000003313104) via UniProtKB, MINT, STRING, and/or I2D (see all 777)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination IDA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0008283cell proliferation IEA--
    GO:0016575histone deacetylation IDA14966270

    MORF4L1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MORF4L1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MORF4L1 (MO4L1)

    1 Novoseek inferred chemical compound relationship for MORF4L1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 26.1 4 11500496 (2), 12397079 (1)

    Search CenterWatch for drugs/clinical trials and news about MORF4L1 / MO4L1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MORF4L1 gene (5 alternative transcripts): 
    NM_001265603.1  NM_001265604.1  NM_001265605.1  NM_006791.3  NM_206839.2  

    Unigene Cluster for MORF4L1:

    Mortality factor 4 like 1
    Hs.374503  [show with all ESTs]
    Unigene Representative Sequence: NM_206839
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000379535 ENST00000559697 ENST00000426013(uc002bem.3 uc010une.2)
    ENST00000331268(uc002bel.3) ENST00000557961 ENST00000559930 ENST00000558746
    ENST00000558893(uc010blj.1) ENST00000558830 ENST00000558522(uc010bli.1)
    ENST00000559619 ENST00000559345 ENST00000561171 ENST00000558502 ENST00000559258
    ENST00000559690 ENST00000559158 ENST00000560422
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    Additional mRNA sequence: 

    AF070664.1 AF100615.1 AF109188.1 AF131847.1 AF161546.1 AF167173.1 AF218011.1 AK098485.1 
    AK296650.1 AK300789.1 AK310702.1 AL137697.1 AY148481.1 BC002936.2 BC022845.2 BC067826.1 
    BC121092.1 BC121093.1 BC141840.1 

    24/56 DOTS entries (see all 56):

    DT.100722399  DT.100891602  DT.100891590  DT.100891587  DT.100891561  DT.91784109  DT.100891566  DT.102838436 
    DT.121068697  DT.95341884  DT.100891585  DT.95164056  DT.100891599  DT.100891605  DT.95164037  DT.97809450 
    DT.100891606  DT.121336510  DT.100891578  DT.100891584  DT.100891595  DT.121336540  DT.95294104  DT.100891592 

    24/1004 AceView cDNA sequences (see all 1004):

    AW273394 BU790454 AA296557 AA053034 CD359955 AA678557 AI250692 BM789552 
    BQ230464 AW069880 BM507358 AA047710 AA984650 BE907020 BI861000 AA875881 
    AW408255 BU186874 CR617357 BM706375 N42881 BM752593 BQ654089 NM_006791 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MORF4L1 expression in normal human tissues (normalized intensities)      MORF4L1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGACGCAA
    MORF4L1 Expression
    About this image


    MORF4L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule

    See MORF4L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MORF4L1

    SOURCE GeneReport for Unigene cluster: Hs.374503
        SABiosciences Custom PCR Arrays for MORF4L1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MORF4L1 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Morf4l11 , 5 mortality factor 4 like 11, 5 91.62(n)1
    99.72(a)1
      9 (47.42 cM)5
    217611  NM_001039147.21  NP_001034236.11 
     900916715 
    chicken
    (Gallus gallus)
    Aves MORF4L16
    mortality factor 4 like 1 isoform 1
    86(a)
    1 → many
    10(19142325-19164790)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    93(a)
    77(a)
    (see all 3)
    many → 1
    possible ortholog
    (see all 3)
    GL343642.1(172846-187211)
    GL343835.1(85152-90372)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA973721.12   -- 81.47(n)    CA973721.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.139502 Transcribed sequence with moderate similarity to protein more 81.34(n)    CA472651.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MRG151 CG6363-PA 54.36(n)
    50.47(a)
      41850  NM_142185.2  NP_650442.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mrg-11 Protein MRG-1 46.76(n)
    32.99(a)
      176702  NM_001129255.1  NP_001122727.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EAF3(YPR023C)4 Esa1p-associated factor, nonessential component of more   --   16(610031-608826) 856134  NP_015348.1 


    ENSEMBL Gene Tree for MORF4L1 (if available)
    TreeFam Gene Tree for MORF4L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MORF4L1 gene
    MORF4L22  
    1 SIMAP similar gene for MORF4L1 using alignment to 12 protein entries:     MO4L1_HUMAN (see all proteins):
    MORF4L2

    MORF4L1 for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for MORF4L1 (see all 9)
    PGOHUM00000242175 PGOHUM00000239350 PGOHUM00000248380 PGOHUM00000244349 PGOHUM00000245210


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/802 SNPs in MORF4L1 are shown (see all 802)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1396235071,2
    --79163171(+) TGGTGG/TGGTGG 3 -- us2k10--------
    rs747374301,2
    C--79163284(+) AGCCCC/TTTCCT 3 -- us2k10--------
    rs745453381,2
    C--79163331(+) TAAAAA/TCCATG 5 -- us2k10--------
    rs1893527421,2
    --79163394(+) AGACAG/TGTTGG 5 -- us2k10--------
    rs1476708251,2
    C--79163399(+) GGTTGA/GACAAG 5 -- us2k10--------
    rs1821930261,2
    --79163532(+) TAAATA/GGAGAG 5 -- us2k10--------
    rs1423260311,2
    --79163549(+) GGAATC/TGGTGG 5 -- us2k10--------
    rs1466015781,2
    --79163556(+) GTGGGG/TTGTGG 5 -- us2k10--------
    rs734776631,2
    C--79163565(+) GGAACC/GCGGGC 5 -- us2k12Minor allele frequency- G:0.05WA 120
    rs47787381,2
    C,F,A,H--79163602(+) GACAGA/GCTGGG 5 -- us2k110Minor allele frequency- G:0.45NA WA CSA EA 372

    HapMap Linkage Disequilibrium report for MORF4L1 (79102829 - 79190475 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MORF4L1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv522996CNV Loss19592680
    nsv904432CNV Loss21882294
    esv33573CNV Gain+Loss17666407

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607303    OMIM disorders: --

    5 diseases for MORF4L1:    About MalaCards
    paraneoplastic cerebellar degeneration    cerebellar degeneration    eaf    retinoblastoma
    breast cancer


    MORF4L1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for MORF4L1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 46 3 11500496 (2), 17008723 (1)
    tumors 0 2 17008723 (1), 11500496 (1)

    Genetic Association Database (GAD): MORF4L1
    Human Genome Epidemiology (HuGE) Navigator: MORF4L1 (2 documents)

    Export disorders for MORF4L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MORF4L1 gene, integrated from 9 sources (see all 65):
    (articles sorted by number of sources associating them with MORF4L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. (PubMed id 12397079)1, 2, 9 Pardo P.S.... Pereira-Smith O.M. (2002)
    2. MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14. (PubMed id 11500496)1, 2, 9 Leung J.K....Pereira-Smith O.M. (2001)
    3. Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and transducin-like enhancer of Split. (PubMed id 12391155)1, 2, 9 Yochum G.S. and Ayer D.E. (2002)
    4. The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14. (PubMed id 17008723)1, 2, 9 Zhang P.... Ding J. (2006)
    5. MRG15 binds directly to PALB2 and stimulates homology -directed repair of chromosomal breaks. (PubMed id 20332121)1, 2, 9 Hayakawa T....Andreassen P.R. (2010)
    6. Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain. (PubMed id 16407074)1, 2, 9 Bowman B.R.... Quiocho F.A. (2006)
    7. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PubMed id 12963728)1, 2, 9 Cai Y.... Conaway J.W. (2003)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    9. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10933 HGNC: 16989 AceView: MORF4L1 Ensembl:ENSG00000185787 euGenes: HUgn10933
    ECgene: MORF4L1 H-InvDB: MORF4L1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MORF4L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MORF4L1 gene:
    Search GeneIP for patents involving MORF4L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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