Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MORF4L1 Gene

Aliases for MORF4L1 Gene

  • Mortality Factor 4 Like 1 2 3
  • MRG15 3 4 6
  • Transcription Factor-Like Protein MRG15 3 4
  • MORF-Related Gene On Chromosome 15 2 3
  • MORF-Related Gene 15 Protein 3 4
  • Protein MSL3-1 3 4
  • Esa1p-Associated Factor 3 Homolog (S. Cerevisiae) 2
  • Esa1p-Associated Factor 3 Homolog 3
  • Mortality Factor 4-Like Protein 1 3
  • HsT17725 3
  • MORFRG15 3
  • FWP006 3
  • S863-6 3
  • MEAF3 3
  • Eaf3 3

External Ids for MORF4L1 Gene

Summaries for MORF4L1 Gene

GeneCards Summary for MORF4L1 Gene

MORF4L1 (Mortality Factor 4 Like 1) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation and RNA Polymerase I Promoter Opening. GO annotations related to this gene include chromatin binding and protein N-terminus binding. An important paralog of this gene is MORF4L2.

UniProtKB/Swiss-Prot for MORF4L1 Gene

  • Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.

Gene Wiki entry for MORF4L1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORF4L1 Gene

Genomics for MORF4L1 Gene

Genomic Location for MORF4L1 Gene

Start:
78,810,487 bp from pter
End:
78,898,133 bp from pter
Size:
87,647 bases
Orientation:
Plus strand

Genomic View for MORF4L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MORF4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORF4L1 Gene

Regulatory Elements for MORF4L1 Gene

Proteins for MORF4L1 Gene

  • Protein details for MORF4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBU8-MO4L1_HUMAN
    Recommended name:
    Mortality factor 4-like protein 1
    Protein Accession:
    Q9UBU8
    Secondary Accessions:
    • B4DKN6
    • B7Z6R1
    • D3DW88
    • O95899
    • Q5QTS1
    • Q6NVX8
    • Q86YT7
    • Q9HBP6
    • Q9NSW5

    Protein attributes for MORF4L1 Gene

    Size:
    362 amino acids
    Molecular mass:
    41474 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the mSin3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with RB1 and KAT8. May also interact with PHF12 and one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors. Interacts with the N-terminus of MRFAP1. Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts with the entire BRCA complex, which contains BRCA1, PALB2, BRCA2 and RAD51. Interacts with PALB2. Forms a complex with MSL1 and NUPR1.
    SequenceCaution:
    • Sequence=AAG17253.1; Type=Frameshift; Positions=348, 360; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MORF4L1 Gene

    Alternative splice isoforms for MORF4L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MORF4L1 Gene

Proteomics data for MORF4L1 Gene at MOPED

Post-translational modifications for MORF4L1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys103, Lys111, Lys117, Lys127, Lys143, Lys198, Lys218, Lys226, Lys240, Lys241, Lys249, Lys339, and Lys51

No data available for DME Specific Peptides for MORF4L1 Gene

Domains for MORF4L1 Gene

Protein Domains for MORF4L1 Gene

UniProtKB/Swiss-Prot:

MO4L1_HUMAN
Domain:
  • Contains 1 MRG domain.:
    • Q9UBU8
genes like me logo Genes that share domains with MORF4L1: view

No data available for Gene Families for MORF4L1 Gene

Function for MORF4L1 Gene

Molecular function for MORF4L1 Gene

UniProtKB/Swiss-Prot Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.

Gene Ontology (GO) - Molecular Function for MORF4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 12963728
GO:0047485 protein N-terminus binding IPI 17577209
genes like me logo Genes that share ontologies with MORF4L1: view
genes like me logo Genes that share phenotypes with MORF4L1: view

Animal Models for MORF4L1 Gene

MGI Knock Outs for MORF4L1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MORF4L1 Gene

Localization for MORF4L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MORF4L1 Gene

Gene Ontology (GO) - Cellular Components for MORF4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0016580 Sin3 complex IDA 14966270
GO:0035267 NuA4 histone acetyltransferase complex IDA 14966270
genes like me logo Genes that share ontologies with MORF4L1: view

Pathways for MORF4L1 Gene

genes like me logo Genes that share pathways with MORF4L1: view

Pathways by source for MORF4L1 Gene

1 Cell Signaling Technology pathway for MORF4L1 Gene

Gene Ontology (GO) - Biological Process for MORF4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IDA 20332121
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with MORF4L1: view

Compounds for MORF4L1 Gene

(1) Novoseek inferred chemical compound relationships for MORF4L1 Gene

Compound -log(P) Hits PubMed IDs
leucine 26.1 3
genes like me logo Genes that share compounds with MORF4L1: view

Transcripts for MORF4L1 Gene

Unigene Clusters for MORF4L1 Gene

Mortality factor 4 like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MORF4L1 Gene

No ASD Table

Relevant External Links for MORF4L1 Gene

GeneLoc Exon Structure for
MORF4L1
ECgene alternative splicing isoforms for
MORF4L1

Expression for MORF4L1 Gene

mRNA expression in normal human tissues for MORF4L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MORF4L1 Gene

SOURCE GeneReport for Unigene cluster for MORF4L1 Gene Hs.374503

genes like me logo Genes that share expressions with MORF4L1: view

Orthologs for MORF4L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MORF4L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MORF4L1 36
  • 99.69 (n)
  • 99.69 (a)
MORF4L1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 75 (a)
OneToMany
-- 37
  • 99 (a)
OneToMany
-- 37
  • 98 (a)
OneToMany
-- 37
  • 58 (a)
OneToMany
MORF4L1 36
  • 90.99 (n)
  • 98.99 (a)
dog
(Canis familiaris)
Mammalia MORF4L1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Morf4l1 36
  • 91.62 (n)
  • 99.72 (a)
Morf4l1 16
Morf4l1 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 96 (a)
ManyToMany
-- 37
  • 59 (a)
ManyToMany
-- 37
  • 64 (a)
ManyToMany
-- 37
  • 59 (a)
ManyToMany
-- 37
  • 57 (a)
ManyToMany
-- 37
  • 20 (a)
ManyToMany
-- 37
  • 20 (a)
ManyToMany
-- 37
  • 18 (a)
ManyToMany
-- 37
  • 19 (a)
ManyToMany
-- 37
  • 19 (a)
ManyToMany
-- 37
  • 54 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
-- 37
  • 51 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 48 (a)
ManyToMany
-- 37
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Morf4l1 36
  • 92.16 (n)
  • 99.38 (a)
chicken
(Gallus gallus)
Aves MORF4L1 37
  • 86 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 62 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii Dr.13950 36
morf4l1 37
  • 88 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta MRG15 37
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cec-7 37
  • 11 (a)
ManyToMany
mrg-1 36
  • 45.66 (n)
  • 33.45 (a)
mrg-1 37
  • 19 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EAF3 37
  • 18 (a)
OneToMany
EAF3 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 48 (a)
ManyToMany
-- 37
  • 37 (a)
ManyToMany
Species with no ortholog for MORF4L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MORF4L1 Gene

ENSEMBL:
Gene Tree for MORF4L1 (if available)
TreeFam:
Gene Tree for MORF4L1 (if available)

Paralogs for MORF4L1 Gene

Paralogs for MORF4L1 Gene

genes like me logo Genes that share paralogs with MORF4L1: view

Variants for MORF4L1 Gene

Sequence variations from dbSNP and Humsavar for MORF4L1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs734287 -- 78,881,558(-) ACCCA(C/T)TGTCC intron-variant
rs1062751 -- 78,897,625(+) ATGCA(C/T)GTTTT utr-variant-3-prime
rs1062752 -- 78,897,644(+) AGACG(C/T)AATGC utr-variant-3-prime
rs1435163 -- 78,893,556(-) TTCTT(G/T)GCAGG synonymous-codon, reference
rs1836556 -- 78,893,535(-) AGCTA(C/T)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MORF4L1 Gene

Variant ID Type Subtype PubMed ID
esv33573 CNV Gain+Loss 17666407
nsv904432 CNV Loss 21882294
nsv522996 CNV Loss 19592680

Relevant External Links for MORF4L1 Gene

HapMap Linkage Disequilibrium report
MORF4L1

Disorders for MORF4L1 Gene

(2) Novoseek inferred disease relationships for MORF4L1 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 46 3
tumors 0 2

Relevant External Links for MORF4L1

Genetic Association Database (GAD)
MORF4L1
Human Genome Epidemiology (HuGE) Navigator
MORF4L1
genes like me logo Genes that share disorders with MORF4L1: view

No data available for UniProtKB/Swiss-Prot for MORF4L1 Gene

Publications for MORF4L1 Gene

  1. MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14. (PMID: 11500496) Leung J.K. … Pereira-Smith O.M. (J. Biol. Chem. 2001) 3 4 23
  2. Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and transducin-like enhancer of Split. (PMID: 12391155) Yochum G.S. … Ayer D.E. (Mol. Cell. Biol. 2002) 3 4 23
  3. MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. (PMID: 12397079) Pardo P.S. … Pereira-Smith O.M. (J. Biol. Chem. 2002) 3 4 23
  4. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PMID: 12963728) Cai Y. … Conaway J.W. (J. Biol. Chem. 2003) 3 4 23
  5. Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain. (PMID: 16407074) Bowman B.R. … Quiocho F.A. (Structure 2006) 3 4 23

Products for MORF4L1 Gene

Sources for MORF4L1 Gene

Back to Top

Content