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Aliases for MORF4 Gene

Aliases for MORF4 Gene

  • Mortality Factor 4 (Pseudogene) 2 3
  • Senescence (Cellular)-Related 1 2 3
  • CSRB 3 6
  • SEN1 3 6
  • Mortality Factor 4 Like 1 Pseudogene 3
  • Senescence-Related, Cellular, 1 3
  • Mortality Factor 4 2
  • CSR 3
  • SEN 3

External Ids for MORF4 Gene

Previous HGNC Symbols for MORF4 Gene

  • SEN
  • SEN1

Previous GeneCards Identifiers for MORF4 Gene

  • GC04M175456
  • GC04M175074
  • GC04M175232
  • GC04M174911
  • GC04M174773
  • GC04M174538
  • GC04M170282

Summaries for MORF4 Gene

Entrez Gene Summary for MORF4 Gene

  • Cellular senescence, the terminal nondividing state that normal cells enter following completion of their proliferative potential, is the dominant phenotype in hybrids of normal and immortal cells. Fusions of immortal human cell lines with each other have led to their assignment to 1 of several complementation groups. MORF4 is a gene on chromosome 4 that induces a senescent-like phenotype in cell lines assigned to complementation group B.[supplied by OMIM, Apr 2004]

GeneCards Summary for MORF4 Gene

MORF4 (Mortality Factor 4 (Pseudogene)) is a Pseudogene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORF4 Gene

Genomics for MORF4 Gene

Regulatory Elements for MORF4 Gene

Genomic Location for MORF4 Gene

173,615,936 bp from pter
173,616,906 bp from pter
971 bases
Minus strand

Genomic View for MORF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MORF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORF4 Gene

Proteins for MORF4 Gene

Post-translational modifications for MORF4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MORF4 Gene

Domains for MORF4 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MORF4 Gene

Function for MORF4 Gene

Molecular function for MORF4 Gene

GENATLAS Biochemistry:
mortality factor 4,expressed in keratinocyte lines,in the TSG4C region,not essential for human keratinocyte immortality

Phenotypes for MORF4 Gene

GenomeRNAi human phenotypes for MORF4:
genes like me logo Genes that share phenotypes with MORF4: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MORF4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MORF4 Gene

Localization for MORF4 Gene

Subcellular locations from

Jensen Localization Image for MORF4 Gene COMPARTMENTS Subcellular localization image for MORF4 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MORF4 Gene

Pathways for MORF4 Gene

genes like me logo Genes that share pathways with MORF4: view

Pathways by source for MORF4 Gene

Interacting Proteins for MORF4 Gene

Gene Ontology (GO) - Biological Process for MORF4 Gene


Transcripts for MORF4 Gene

mRNA/cDNA for MORF4 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MORF4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MORF4 Gene

No ASD Table

Relevant External Links for MORF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MORF4 Gene

mRNA expression in normal human tissues for MORF4 Gene

genes like me logo Genes that share expressions with MORF4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MORF4 Gene

Orthologs for MORF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MORF4 Gene

Organism Taxonomy Gene Similarity Type Details
fruit fly
(Drosophila melanogaster)
Insecta MRG15 37
  • 50 (a)
Species with no ortholog for MORF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MORF4 Gene

Gene Tree for MORF4 (if available)
Gene Tree for MORF4 (if available)

Paralogs for MORF4 Gene

No data available for Paralogs for MORF4 Gene

Variants for MORF4 Gene

Relevant External Links for MORF4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MORF4 Gene

Disorders for MORF4 Gene

(1) University of Copenhagen DISEASES for MORF4 Gene

Relevant External Links for MORF4

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with MORF4: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for MORF4 Gene

Publications for MORF4 Gene

  1. A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23. (PMID: 12407449) Bryce S.D. … Parkinson E.K. (Neoplasia 2002) 2 3
  2. Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on human chromosome 4. (PMID: 2062841) Ning Y. … Pereira-Smith O.M. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3
  3. Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. (PMID: 9891081) Bertram M.J. … Pereira-Smith O.M. (Mol. Cell. Biol. 1999) 2 3
  4. Genetic and functional analyses exclude mortality factor 4 (MORF4) as a keratinocyte senescence gene. (PMID: 10232582) Bryce S.D. … Parkinson E.K. (Cancer Res. 1999) 3
  5. Genetic approaches to the study of replicative senescence. (PMID: 10705034) Ran Q. … Pereira-Smith O.M. (Exp. Gerontol. 2000) 3

Products for MORF4 Gene

Sources for MORF4 Gene

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