|
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mortality factor 4(Previous names: senescence (cellular)-related 1, mortality factor 4 )
(Previous symbols: SEN, SEN1)
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Aliases
for MORF4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mortality Factor 41 2 | | SEN11 2 5 | | SEN1 2 | | CSRB2 5 | | Senescence (Cellular)-Related 11 | | CSR2 |
Export aliases for MORF4 gene to outside databasesPrevious GC identifers: GC04M175456 GC04M175074 GC04M175232 GC04M174911 GC04M174773 GC04M170282 |
Summaries
for MORF4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MORF4:
Cellular senescence, the terminal nondividing state that normal cells enter following completion of their proliferativepotential, is the dominant phenotype in hybrids of normal and immortal cells. Fusions of immortal human cell lineswith each other have led to their assignment to 1 of several complementation groups. MORF4 is a gene on chromosome 4that induces a senescent-like phenotype in cell lines assigned to complementation group B.(supplied by OMIM, Apr 2004)
|
Genomic Views
for MORF4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MORF4 gene promoter:
ATF-2 MEF-2 POU3F2 Tal-1beta MEF-2A POU2F1 POU2F1a COMP1 aMEF-2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MORF4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MORF4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q34.1 Ensembl cytogenetic band: 4q34.1 HGNC cytogenetic band: 4q34.1MORF4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M174538: view genomic region
(about GC identifiers)
Start:
|
174,537,087 bp from pter |
End:
|
174,538,057 bp from pter |
Size:
|
971 bases |
Orientation:
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minus strand |
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Proteins
for MORF4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB: --
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_
MORF4 Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
Antibody Products for MORF4:
Assay Products for MORF4: |
Protein
Domains /
Families
for MORF4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for MORF4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for MORF4:mortality factor 4,expressed in keratinocyte lines,in the TSG4C region,not essential for human keratinocyte immortality
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MORF4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MORF4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 16): MORF4 (NM_001142418) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MORF4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORF4 |
1 GenomeRNAi human phenotype for MORF4:
|
Pathways & Interactions
for MORF4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MORF4
|
Drugs & Compounds
for MORF4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MORF4
Search CenterWatch for drugs/clinical trials and news about MORF4
|
Transcripts
for MORF4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MORF4 gene: NM_006792.2 2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000447135 ENST00000434007
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MORF4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MORF4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 16): MORF4 (NM_001142418) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MORF4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORF4 |
4 AceView cDNA sequences: NM_006792 D82751 BE814292 CD623274
GeneLoc Exon Structure
|
Expression
for MORF4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MORF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for MORF4
SABiosciences Custom PCR Arrays for MORF4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MORF4
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MORF4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MORF4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORF4 |
Orthologs
for MORF4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for MORF4 (if available)
TreeFam Gene Tree for MORF4 (if available) |
Paralogs
for MORF4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MORF4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MORF4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MORF4 for disorders About GeneDecksing
OMIM gene information: 116960
OMIM disorders: --
5  diseases for MORF4: About MalaCardsstaphyloenterotoxemia scrapie apraxia shigellosis
adenocarcinoma
Export disorders for MORF4 gene to outside databases
|
Publications
for MORF4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MORF4 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with MORF4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23. (PubMed id 12407449)1, 3 Bryce S.D....Parkinson E.K. (2002)
- Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. (PubMed id 9891081)1, 3 Bertram M.J.... Pereira-Smith O.M. (1999)
- Genetic analysis of indefinite division in human cell s: evidence for a cell senescence-related gene(s) on human chromosome 4. (PubMed id 2062841)1, 3 Ning Y....Pereira-Smith O.M. (1991)
- Conditional inactivation of MRG15 gene function limit s survival during larval and adult stages of Drosophila melanogaster. (PubMed id 20600782)1 Zhang H....Tower J. (2010)
- The cell senescence inducing gene product MORF4 is re gulated by degradation via the ubiquitin/proteasome pathway. (PubMed id 19769966)1 Tominaga K....Pereira-Smith O.M. (2010)
- Emerging role of the MORF/MRG gene family in various biological processes, including aging. (PubMed id 20536842)1 Chen M....Pereira-Smith O.M. (2010)
- The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging. (PubMed id 17460191)1 Pena A.N. and Pereira-Smith O.M. (2007)
- Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and transducin-like enhancer of Split. (PubMed id 12391155)1 Yochum G.S. and Ayer D.E. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Conservation of the MORF4 related gene family: identification of a new chromo domain subfamily and novel protein motif. (PubMed id 11290425)1 Bertram M.J. and Pereira-Smith O.M. (2001)
|
External Searches for MORF4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MORF4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MORF4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MORF4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MORF4 gene:
Search GeneIP for patents involving MORF4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MORF4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MORF4 | | OriGene shRNA RFP for MORF4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MORF4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MORF4 | | | OriGene Protein Over-expression Lysate for MORF4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MORF4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MORF4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MORF4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MORF4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MORF4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MORF4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MORF4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORF4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MORF4 |
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| | | | Search Tocris compounds for MORF4 |
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 | | | MORF4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for MORF4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORF4 |
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