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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MORC4 Gene

protein-coding   GIFtS: 50
GCID: GC0XM106183

MORC family CW-type zinc finger 4

(Previous names: zinc finger, CW-type with coiled-coil domain 2, zinc finger,...)
(Previous symbol: ZCWCC2)
 Explore 2 diseases affiliated with
MORC4 via our new
 Human Malady Compendium 
Biological research products
for MORC4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
MORC Family CW-Type Zinc Finger 41 2     FLJ115651
ZCWCC21 2 3     Zinc Finger, CW-Type With Coiled-Coil Domain 21
ZCW41 2     DJ75H8.21
Zinc Finger, CW Type With Coiled-Coil Domain 21 2     MORC Family CW-Type Zinc Finger Protein 42
Zinc Finger CW-Type Coiled-Coil Domain Protein 22 3     

External Ids:    HGNC: 234851   Entrez Gene: 797102   Ensembl: ENSG000001331317   UniProtKB: Q8TE763   

Export aliases for MORC4 gene to outside databases

Previous GC identifers: GC0XM105992 GC0XM106070 GC0XM095811


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MORC4:
In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding
region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding
domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal
tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript
variants encoding distinct proteins. (provided by RefSeq, Jan 2010)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MORC4 gene promoter:
         Olf-1   Lmo2   IRF-1   MZF-1   POU2F1   POU2F1a   c-Myb   Ik-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMORC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MORC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MORC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.3

MORC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORC4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM106183:  view genomic region     (about GC identifiers)

Start:
106,183,964 bp from pter      End:
106,243,474 bp from pter
Size:
59,511 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MORC4_HUMAN, Q8TE76 (See protein sequence)
Recommended Name: MORC family CW-type zinc finger protein 4  
Size: 937 amino acids; 106348 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB13859.1; Type=Erroneous initiation; Sequence=BAB71125.1; Type=Erroneous initiation;
Secondary accessions: A1YR23 A1YR24 H7BXF1 Q5JUK7 Q96MZ2 Q9HAI7
Alternative splicing: 3 isoforms:  Q8TE76-1   Q8TE76-2   Q8TE76-3   

Explore the universe of human proteins at neXtProt for MORC4: NX_Q8TE76

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TE76

  • MORC4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001078823.1  NP_078933.3  

    ENSEMBL proteins: 
     ENSP00000347821   ENSP00000255495   ENSP00000440359  

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    Uscn Proteins for MORC4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    MORC4 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MORC4 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003594 ATPase-like_ATP-bd
     IPR011124 Znf_CW

    Graphical View of Domain Structure for InterPro Entry Q8TE76

    ProtoNet protein and cluster: Q8TE76

    2 Blocks protein families:
    IPB003594 ATP-binding region
    IPB011124 CW-type Zn-finger


    UniProtKB/Swiss-Prot: MORC4_HUMAN, Q8TE76
    Similarity: Contains 1 CW-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    hsa-miR-3910 hsa-miR-3140-3p hsa-miR-4297 hsa-miR-3133 hsa-miR-3647-3p hsa-miR-3667-3p hsa-miR-124 hsa-miR-9*
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    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0008270zinc ion binding IEA--


    MORC4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MORC4:
     Increased Salmonella enterica  


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MORC4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for MORC4 (Q8TE761, 2, 3 ENSP000003478214) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61656 I2D: score=3 
    STAT3P407631, ENSP000002646574EBI-3940432,EBI-518675 STRING: ENSP00000264657
    UBCENSP000003448184STRING: ENSP00000344818
    GEMIN4ENSP000003217064STRING: ENSP00000321706
    PRKAA1ENSP000003461484STRING: ENSP00000346148
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MORC4
    Search CenterWatch for drugs/clinical trials and news about MORC4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MORC4 gene (2 alternative transcripts): 
    NM_001085354.2  NM_024657.4  

    Unigene Cluster for MORC4:

    MORC family CW-type zinc finger 4
    Hs.496544  [show with all ESTs]
    Unigene Representative Sequence: NM_024657
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355610(uc004emu.4 uc004emv.4) ENST00000255495 ENST00000478924
    ENST00000535534(uc004emw.4)

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    hsa-miR-3910 hsa-miR-3140-3p hsa-miR-4297 hsa-miR-3133 hsa-miR-3647-3p hsa-miR-3667-3p hsa-miR-124 hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidMORC4 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK021627.1 AK056235.1 AK300305.1 AY927537.1 BC009313.2 EF125209.1 EF125210.1 

    8 DOTS entries:

    DT.412385  DT.100748195  DT.101975728  DT.121291639  DT.91925193  DT.92427475  DT.92427477  DT.92450621 

    24/86 AceView cDNA sequences (see all 86):

    BF198070 BG676064 BQ101064 CR594041 AA326884 BE677450 AI168751 BX348377 
    AA099522 BM021172 CA448781 BX100548 BX348378 AA873707 CR613067 BM978497 
    BM053037 BM023168 AA644246 C01123 AI689215 CA391555 AA099523 AI273680 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MORC4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b
    SP1:                                                        -                                                                       -               
    SP2:                                                                                                                                                
    SP3:                                                                                                                                                
    SP4:                                                                                                                          -     -               
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for MORC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MORC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCACACTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    MORC4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MORC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MORC4

    SOURCE GeneReport for Unigene cluster: Hs.496544

    UniProtKB/Swiss-Prot: MORC4_HUMAN, Q8TE76
    Tissue specificity: Expressed at low levels in normal tissues, with highest expression levels in placenta and testis.
    Expression is significantly increased in subset of diffuse large B-cell lymphomas

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MORC4 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1527746
    zgc:152774
    57(a)
    1 ↔ 1
    Zv9_NA47(9456-34743)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G362706
    AT4G362806
    (see all 7)
    ATP binding protein
    histidine kinase-like ATPase domain-containing pro...
    (see all 7)
    24(a)
    24(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    4(17161024-17165241)
    4(17165331-17169375)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 6)
    ATP-binding region, ATPase-like domain containing ...
    ATP-binding region, ATPase-like domain containing ...
    (see all 6)
    26(a)
    22(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    10(5611556-5626984)
    4(14076101-14085810)


    ENSEMBL Gene Tree for MORC4 (if available)
    TreeFam Gene Tree for MORC4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MORC4 gene
    MORC22  MORC32  MORC12  
    1 SIMAP similar gene for MORC4 using alignment to 2 protein entries:     MORC4_HUMAN (see all proteins):
    MORC3

    MORC4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/593 NCBI SNPs in MORC4 are shown (see all 593    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872454781,2
    --106183583(+) ACCCCC/TCACTC 2 -- ds50010--------
    rs120147621,2
    C,F,H,--106183670(+) GAAATT/CCCATT 2 -- ds500118Minor allele frequency- C:0.83NS EA NA 2296
    rs169872251,2
    C,F,H,--106183750(+) AATACC/TAAAGC 2 -- ds500111--NA NS EA WA CSA 568
    rs1132657791,2
    --106183806(+) CACCAT/CTTCTA 2 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs1824717581,2
    --106184019(+) TTAATA/GTTGAA 2 -- ut310--------
    rs151231,2
    C--106184044(+) AGGAAG/TATAGG 2 -- ut311Minor allele frequency- T:0.00NA 2
    rs1867566081,2
    --106184076(+) AGTCCC/TACCAC 2 -- ut310--------
    rs1511642641,2
    --106184221(+) ATATCA/TTACAC 2 -- ut310--------
    rs1903780381,2
    --106184402(+) AGATAC/TACAAT 2 -- ut310--------
    rs1391448221,2
    --106184423(+) TCCAGA/GTCATG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MORC4 (106183964 - 106243474 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for MORC4
         2 CNVs: 8310 0251
    Locus Specific Mutation Databases (LSDB): MORC4

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MORC4
    DNA2.0 Custom Variant and Variant Library Synthesis for MORC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MORC4 for disorders           About GeneDecksing

    2 diseases for MORC4:    About MalaCards
    diffuse large b-cell lymphoma    b-cell lymphomas


    Export disorders for MORC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MORC4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MORC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas. (PubMed id 17608765)1, 2, 9 Liggins A.P....Banham A.H. (2007)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PubMed id 14607086)1, 3 Perry J. and Zhao Y. (2003)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. (PubMed id 15790807)1 Cheng J....Gingeras T.R. (2005)
    9. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79710 HGNC: 23485 AceView: ZCWCC2 Ensembl:ENSG00000133131 euGenes: HUgn79710
    ECgene: MORC4 H-InvDB: MORC4

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MORC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for MORC4 gene:
    Search GeneIP for patents involving MORC4

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