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Aliases for MORC4 Gene

Aliases for MORC4 Gene

  • MORC Family CW-Type Zinc Finger 4 2 3 5
  • Zinc Finger CW-Type Coiled-Coil Domain Protein 2 3 4
  • Zinc Finger, CW Type With Coiled-Coil Domain 2 2 3
  • ZCWCC2 3 4
  • Zinc Finger, CW-Type With Coiled-Coil Domain 2 2
  • DJ75H8.2 3
  • ZCW4 3

External Ids for MORC4 Gene

Previous HGNC Symbols for MORC4 Gene

  • ZCWCC2

Previous GeneCards Identifiers for MORC4 Gene

  • GC0XM105992
  • GC0XM106070
  • GC0XM106183
  • GC0XM095811

Summaries for MORC4 Gene

Entrez Gene Summary for MORC4 Gene

  • In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]

GeneCards Summary for MORC4 Gene

MORC4 (MORC Family CW-Type Zinc Finger 4) is a Protein Coding gene. Diseases associated with MORC4 include b-cell lymphomas. An important paralog of this gene is MORC3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORC4 Gene

Genomics for MORC4 Gene

Regulatory Elements for MORC4 Gene

Promoters for MORC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MORC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for MORC4 Gene

Chromosome:
X
Start:
106,813,871 bp from pter
End:
107,000,244 bp from pter
Size:
186,374 bases
Orientation:
Minus strand

Genomic View for MORC4 Gene

Genes around MORC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORC4 Gene

Proteins for MORC4 Gene

  • Protein details for MORC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE76-MORC4_HUMAN
    Recommended name:
    MORC family CW-type zinc finger protein 4
    Protein Accession:
    Q8TE76
    Secondary Accessions:
    • A1YR23
    • A1YR24
    • H7BXF1
    • Q5JUK7
    • Q96MZ2
    • Q9HAI7

    Protein attributes for MORC4 Gene

    Size:
    937 amino acids
    Molecular mass:
    106348 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13859.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71125.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MORC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MORC4 Gene

Proteomics data for MORC4 Gene at MOPED

Post-translational modifications for MORC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MORC4 Gene

No data available for DME Specific Peptides for MORC4 Gene

Domains & Families for MORC4 Gene

Gene Families for MORC4 Gene

Protein Domains for MORC4 Gene

Suggested Antigen Peptide Sequences for MORC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TE76

UniProtKB/Swiss-Prot:

MORC4_HUMAN :
  • Contains 1 CW-type zinc finger.
Similarity:
  • Contains 1 CW-type zinc finger.
genes like me logo Genes that share domains with MORC4: view

Function for MORC4 Gene

Gene Ontology (GO) - Molecular Function for MORC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with MORC4: view

Phenotypes for MORC4 Gene

genes like me logo Genes that share phenotypes with MORC4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MORC4 Gene

Localization for MORC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MORC4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MORC4 Gene COMPARTMENTS Subcellular localization image for MORC4 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for MORC4 Gene

Pathways & Interactions for MORC4 Gene

SuperPathways for MORC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MORC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MORC4 Gene

Drugs & Compounds for MORC4 Gene

No Compound Related Data Available

Transcripts for MORC4 Gene

Unigene Clusters for MORC4 Gene

MORC family CW-type zinc finger 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MORC4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b
SP1: - -
SP2:
SP3:
SP4: - -
SP5:

Relevant External Links for MORC4 Gene

GeneLoc Exon Structure for
MORC4
ECgene alternative splicing isoforms for
MORC4

Expression for MORC4 Gene

mRNA expression in normal human tissues for MORC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MORC4 Gene

This gene is overexpressed in Fetal gut (41.4), Pancreas (19.1), and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MORC4 Gene



SOURCE GeneReport for Unigene cluster for MORC4 Gene Hs.496544

mRNA Expression by UniProt/SwissProt for MORC4 Gene

Q8TE76-MORC4_HUMAN
Tissue specificity: Expressed at low levels in normal tissues, with highest expression levels in placenta and testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas.
genes like me logo Genes that share expression patterns with MORC4: view

Protein tissue co-expression partners for MORC4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MORC4 Gene

Orthologs for MORC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MORC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MORC4 35
  • 91.2 (n)
  • 89.32 (a)
-- 36
  • 96 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MORC4 35
  • 90.08 (n)
  • 90.04 (a)
MORC4 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Morc4 35
  • 85.94 (n)
  • 82.09 (a)
Morc4 16
Morc4 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Morc4 35
  • 85.01 (n)
  • 81.34 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia MORC4 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MORC4 36
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MORC4 36
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea morc-1 36
  • 19 (a)
OneToMany
Species with no ortholog for MORC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MORC4 Gene

ENSEMBL:
Gene Tree for MORC4 (if available)
TreeFam:
Gene Tree for MORC4 (if available)

Paralogs for MORC4 Gene

Paralogs for MORC4 Gene

(1) SIMAP similar genes for MORC4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MORC4: view

Variants for MORC4 Gene

Sequence variations from dbSNP and Humsavar for MORC4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs6622126 - 106,956,972(+) CATCA(A/G)TGAGT reference, missense
rs3827464 - 106,942,934(-) ACCAA(C/T)GCCAG reference, missense
rs15123 -- 106,940,814(+) AGGAA(G/T)ATAGG utr-variant-3-prime
rs716116 -- 106,983,461(+) AGGAA(A/G)AATAC intron-variant
rs1318418 -- 106,984,027(+) cacgg(G/T)ggctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MORC4 Gene

Variant ID Type Subtype PubMed ID
esv2752312 CNV Gain 17911159
nsv482964 CNV Loss 15286789
nsv519484 CNV Gain 19592680

Variation tolerance for MORC4 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MORC4 Gene

HapMap Linkage Disequilibrium report
MORC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MORC4 Gene

Disorders for MORC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MORC4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
b-cell lymphomas
  • b-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search MORC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MORC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MORC4
genes like me logo Genes that share disorders with MORC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MORC4 Gene

Publications for MORC4 Gene

  1. MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas. (PMID: 17608765) Liggins A.P. … Banham A.H. (Br. J. Haematol. 2007) 3 4 23 67
  2. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PMID: 14607086) Perry J. … Zhao Y. (Trends Biochem. Sci. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study. (PMID: 25253127) Derikx M.H. … Rosendahl J. (Gut 2014) 3
  5. Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease. (PMID: 23946598) SAPderman J. … Almer S. (World J. Gastroenterol. 2013) 3

Products for MORC4 Gene

Sources for MORC4 Gene

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