MORC4 Gene
protein-coding GIFtS : 50
GCID: GC0X M106183
MORC family CW-type zinc finger 4 (Previous names: zinc finger, CW-type with coiled-coil domain 2, zinc finger,... ) (Previous symbol: ZCWCC2 )
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Aliasesfor MORC4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases MORC Family CW-Type Zinc Finger 4 1 2 FLJ115651 ZCWCC21 2 3 Zinc Finger, CW-Type With Coiled-Coil Domain 21 ZCW41 2 DJ75H8.21 Zinc Finger, CW Type With Coiled-Coil Domain 21 2 MORC Family CW-Type Zinc Finger Protein 42 Zinc Finger CW-Type Coiled-Coil Domain Protein 22 3
Export aliases for MORC4 gene to outside databases Previous GC identifers: GC0XM105992 GC0XM106070 GC0XM095811
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Summariesfor MORC4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MORC4 : In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. (provided by RefSeq, Jan 2010)
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Genomic Viewsfor MORC4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_011651.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MORC4 gene promoter: Olf-1 Lmo2 IRF-1 MZF-1 POU2F1 POU2F1a c-Myb Ik-1 c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for MORC4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MORC4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq22.3 Ensembl cytogenetic band: Xq22.3 HGNC cytogenetic band: Xq22.3 MORC4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM106183: view genomic region
(about GC identifiers )
Start:
106,183,964 bp from pter
End:
106,243,474 bp from pter
Size:
59,511 bases
Orientation:
minus strand
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Proteinsfor MORC4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MORC4_HUMAN, Q8TE76 (See
protein sequence )Recommended Name: MORC family CW-type zinc finger protein 4 Size : 937 amino acids; 106348 Da
Subcellular location : Nucleus (Probable)
Sequence caution : Sequence=BAB13859.1; Type=Erroneous initiation; Sequence=BAB71125.1; Type=Erroneous initiation;
Secondary accessions : A1YR23 A1YR24 H7BXF1 Q5JUK7 Q96MZ2 Q9HAI7Alternative splicing : 3 isoforms : Q8TE76-1 Q8TE76-2 Q8TE76-3 Explore the universe of human proteins at neXtProt for MORC4: NX_Q8TE76 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8TE76 MORC4 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001078823.1 NP_078933.3 ENSEMBL proteins: ENSP00000347821 ENSP00000255495 ENSP00000440359 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
MORC4 for ontologies About GeneDecksing MORC4 Antibody Products: Assay Products for MORC4:
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Protein
Domains / Familiesfor MORC4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MORC4 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8TE76 ProtoNet protein and cluster: Q8TE76
2 Blocks protein families : IPB003594 ATP-binding region IPB011124 CW-type Zn-finger UniProtKB/Swiss-Prot: MORC4_HUMAN, Q8TE76 Similarity : Contains 1 CW-type zinc finger
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Functionfor MORC4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MORC4 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MORC4 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): MORC4 (NM_024657 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MORC4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MORC4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORC4
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
MORC4 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for MORC4 :
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Pathways & Interactionsfor MORC4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MORC4 STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)5/6 Interacting proteins for MORC4 (Q8TE76 1 , 2 , 3 ENSP00000347821 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 6 )About this table
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Drugs & Compoundsfor MORC4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MORC4 Search CenterWatch for drugs/clinical trials and news about MORC4
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Transcriptsfor MORC4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MORC4 gene (2 alternative transcripts): NM_001085354.2 NM_024657.4 Unigene Cluster for MORC4:
MORC family CW-type zinc finger 4 Hs.496544 [show with all ESTs ] Unigene Representative Sequence: NM_024657 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000355610 (uc004emu.4 uc004emv.4 ) ENST00000255495 ENST00000478924 ENST00000535534 (uc004emw.4 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MORC4 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MORC4 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): MORC4 (NM_024657 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MORC4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MORC4
Additional cDNA sequence: AK021627.1 AK056235.1 AK300305.1 AY927537.1 BC009313.2 EF125209.1 EF125210.1
8 DOTS entries : DT.412385 DT.100748195
DT.101975728 DT.121291639 DT.91925193 DT.92427475 DT.92427477 DT.92450621 24/86 AceView cDNA sequences (see all 86 ):
BF198070 BG676064 BQ101064 CR594041 AA326884 BE677450 AI168751 BX348377 AA099522 BM021172 CA448781 BX100548 BX348378 AA873707 CR613067 BM978497 BM053037 BM023168 AA644246 C01123 AI689215 CA391555 AA099523 AI273680 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for MORC4 About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b SP1 :                   -                         -       SP2 :                                                 SP3 :                                                 SP4 :                                         -   -       SP5 :                                                
ECgene alternative splicing isoforms for MORC4
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Expression for MORC4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MORC4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCCACACTGT
About this image MORC4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See MORC4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MORC4 SOURCE GeneReport for Unigene cluster: Hs.496544 UniProtKB/Swiss-Prot: MORC4_HUMAN, Q8TE76 Tissue specificity : Expressed at low levels in normal tissues, with highest expression levels in placenta and testis.Expression is significantly increased in subset of diffuse large B-cell lymphomas SABiosciences Custom PCR Arrays for MORC4 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MORC4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MORC4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MORC4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MORC4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORC4
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Orthologsfor MORC4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for MORC4 gene from 3/10 species (see all 10 ) About this table
ENSEMBL Gene Tree for MORC4 (if available)TreeFam Gene Tree for MORC4 (if available)
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Paralogsfor MORC4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MORC4 gene MORC2 2 MORC3 2 MORC1 2 1 SIMAP similar gene for MORC4 using alignment to 2 protein entries: MORC4_HUMAN (see all proteins ):MORC3
MORC4 for paralogs About GeneDecksing
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Genomic Variantsfor MORC4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MORC4 (106183964 - 106243474 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for MORC4 2 CNVs : 8310 0251 Locus Specific Mutation Databases (LSDB): MORC4
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MORC4
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Disorders
/ Diseasesfor MORC4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MORC4 for disorders About GeneDecksing 2 diseases for MORC4 : About MalaCards diffuse large b-cell lymphoma b-cell lymphomas Export disorders for MORC4 gene to outside databases
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Publicationsfor MORC4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MORC4 gene integrated from 9 sources : (articles sorted by number of sources associating them with MORC4) Utopia : connect your pdf to the dynamic world of online information
MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas. (PubMed id 17608765) 1 , 2 , 9 Liggins A.P....Banham A.H. (2007) The DNA sequence of the human X chromosome. (PubMed id 15772651) 1 , 2 Ross M.T.... Bentley D.R. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PubMed id 14607086) 1 , 3 Perry J. and Zhao Y. (2003) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. (PubMed id 15790807) 1 Cheng J....Gingeras T.R. (2005) Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748) 1 Colland F....Gauthier J.M. (2004)
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External Searches for MORC4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MORC4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MORC4 gene
(According to HUGE )
About This Section --
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Specialized Databases showing MORC4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MORC4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MORC4 gene: Search GeneIP for patents involving MORC4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MORC4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MORC4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MORC4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MORC4 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MORC4 OriGene 3'-UTR Clone for MORC4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MORC4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MORC4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MORC4 OriGene Custom Protein Services for MORC4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MORC4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MORC4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MORC4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MORC4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MORC4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MORC4
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MORC4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORC4
Search ThermoFisher Antibodies for MORC4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MORC4
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Aliases for MORC4
Databases for MORC4
Disorders / Diseases for MORC4
Domains / Families for MORC4
Drugs / Compounds for MORC4
Expression for MORC4
Function for MORC4
Genomic Views for MORC4
Intellectual Property for MORC4
Orthologs for MORC4
Paralogs for MORC4
Pathways / Interactions for MORC4
Products for MORC4
Proteins for MORC4
Publications for MORC4
Search Box for MORC4
Summaries for MORC4
Transcripts for MORC4
Variants for MORC4
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