Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MORC4 Gene

protein-coding   GIFtS: 50
GCID: GC0XM106070

MORC Family CW-Type Zinc Finger 4

(Previous names: zinc finger, CW-type with coiled-coil domain 2, zinc finger,...)
(Previous symbol: ZCWCC2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MORC Family CW-Type Zinc Finger 41 2     Zinc Finger, CW-Type With Coiled-Coil Domain 21
ZCWCC21 2 3     ZCW42
Zinc Finger, CW Type With Coiled-Coil Domain 21 2     dJ75H8.22
Zinc Finger CW-Type Coiled-Coil Domain Protein 22 3     MORC Family CW-Type Zinc Finger Protein 42

External Ids:    HGNC: 234851   Entrez Gene: 797102   Ensembl: ENSG000001331317   UniProtKB: Q8TE763   

Export aliases for MORC4 gene to outside databases

Previous GC identifers: GC0XM105992 GC0XM106183 GC0XM095811


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MORC4 Gene:
In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like
ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear
matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at
low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in
multiple transcript variants encoding distinct proteins. (provided by RefSeq, Jan 2010)

GeneCards Summary for MORC4 Gene: 
MORC4 (MORC family CW-type zinc finger 4) is a protein-coding gene. Diseases associated with MORC4 include diffuse large b-cell lymphoma, and b-cell lymphomas. GO annotations related to this gene include zinc ion binding and ATP binding. An important paralog of this gene is MORC2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011651.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MORC4 gene promoter:
         Olf-1   Lmo2   IRF-1   MZF-1   POU2F1   POU2F1a   c-Myb   Ik-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMORC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MORC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MORC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.3

MORC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORC4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM106070:  view genomic region     (about GC identifiers)

Start:
106,057,101 bp from pter      End:
106,243,474 bp from pter
Size:
186,374 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MORC4_HUMAN, Q8TE76 (See protein sequence)
Recommended Name: MORC family CW-type zinc finger protein 4  
Size: 937 amino acids; 106348 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB13859.1; Type=Erroneous initiation; Sequence=BAB71125.1; Type=Erroneous initiation;
Secondary accessions: A1YR23 A1YR24 H7BXF1 Q5JUK7 Q96MZ2 Q9HAI7
Alternative splicing: 3 isoforms:  Q8TE76-1   Q8TE76-2   Q8TE76-3   

Explore the universe of human proteins at neXtProt for MORC4: NX_Q8TE76

Explore proteomics data for MORC4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TE76

  • MORC4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MORC4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001078823.1  NP_078933.3  

    ENSEMBL proteins: 
     ENSP00000474750   ENSP00000347821   ENSP00000255495   ENSP00000440359  

    Human Recombinant Protein Products for MORC4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MORC4
    GenScript Custom Purified and Recombinant Proteins Services for MORC4
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MORC4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    MORC4 for ontologies           About GeneDecksing



    MORC4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MORC4
    GenScript Custom Superior Antibodies Services for MORC4
    Novus Biologicals MORC4 Antibody
    Abcam antibodies for MORC4
    Cloud-Clone Corp. Antibodies for MORC4 
    Search ThermoFisher Antibodies for MORC4
    Search LSBio for Antibodies for MORC4 

    Assay Products for MORC4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MORC4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MORC4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MORC4 
    Cloud-Clone Corp. CLIAs for MORC4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR003594 HATPase_ATP-bd
     IPR011124 Znf_CW

    Graphical View of Domain Structure for InterPro Entry Q8TE76

    ProtoNet protein and cluster: Q8TE76

    2 Blocks protein domains:
    IPB003594 ATP-binding region
    IPB011124 CW-type Zn-finger


    UniProtKB/Swiss-Prot: MORC4_HUMAN, Q8TE76
    Similarity: Contains 1 CW-type zinc finger


    MORC4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0008270zinc ion binding IEA--
         
    MORC4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MORC4:
     Increased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MORC4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MORC4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MORC4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MORC4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MORC4
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate MORC4 (see all 11):
    hsa-miR-3910 hsa-miR-3140-3p hsa-miR-4297 hsa-miR-3133 hsa-miR-3647-3p hsa-miR-3667-3p hsa-miR-124 hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidMORC4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MORC4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MORC4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MORC4
    Sirion Biotech Customized adenovirus for overexpression of MORC4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MORC4 (see all 12)
    OriGene ORF clones in mouse, rat for MORC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MORC4 (NM_024657)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MORC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORC4
    Sirion Biotech Customized lentivirus for stable overexpression of MORC4 
                         Customized lentivirus expression plasmids for stable overexpression of MORC4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MORC4
    Search LifeMap BioReagents cell lines for MORC4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORC4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MORC4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for MORC4 (Q8TE761, 2, 3 ENSP000003478214) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61656 I2D: score=3 
    STAT3P407631, ENSP000002646574EBI-3940432,EBI-518675 STRING: ENSP00000264657
    UBCENSP000003448184STRING: ENSP00000344818
    GEMIN4ENSP000003217064STRING: ENSP00000321706
    PRKAA1ENSP000003461484STRING: ENSP00000346148
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MORC4

    Search CenterWatch for drugs/clinical trials and news about MORC4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MORC4 gene (2 alternative transcripts): 
    NM_001085354.2  NM_024657.4  

    Unigene Cluster for MORC4:

    MORC family CW-type zinc finger 4
    Hs.496544  [show with all ESTs]
    Unigene Representative Sequence: NM_024657
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000604604 ENST00000355610(uc004emu.4 uc004emv.4) ENST00000255495
    ENST00000478924 ENST00000535534(uc004emw.4)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MORC4
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate MORC4 (see all 11):
    hsa-miR-3910 hsa-miR-3140-3p hsa-miR-4297 hsa-miR-3133 hsa-miR-3647-3p hsa-miR-3667-3p hsa-miR-124 hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidMORC4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MORC4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MORC4
    Clone
    Products:
         
    OriGene clones in human, mouse for MORC4 (see all 12)
    OriGene ORF clones in mouse, rat for MORC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MORC4 (NM_024657)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MORC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORC4
    Sirion Biotech Customized lentivirus for stable overexpression of MORC4 
                         Customized lentivirus expression plasmids for stable overexpression of MORC4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MORC4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MORC4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MORC4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORC4

    Additional mRNA sequence: 

    AK021627.1 AK056235.1 AK300305.1 AY927537.1 BC009313.2 EF125209.1 EF125210.1 

    8 DOTS entries:

    DT.412385  DT.100748195  DT.101975728  DT.121291639  DT.91925193  DT.92427475  DT.92427477  DT.92450621 

    24/86 AceView cDNA sequences (see all 86):

    CA391555 BG676064 BF198070 CA448781 AA099522 CR594041 AI689215 AA873707 
    BX348377 BM021172 AI168751 BX348378 BM978497 BX100548 C01123 AA099523 
    AA644246 AI273680 AA326884 CR613067 BM053037 BQ101064 BE677450 BM023168 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MORC4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b
    SP1:                                                        -                                                                       -               
    SP2:                                                                                                                                                
    SP3:                                                                                                                                                
    SP4:                                                                                                                          -     -               
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for MORC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MORC4 expression in normal human tissues (normalized intensities)      MORC4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCACACTGT
    MORC4 Expression
    About this image


    MORC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Testis (Reproductive System)
     
     Placenta (Extraembryonic Tissues)

    See MORC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MORC4

    SOURCE GeneReport for Unigene cluster: Hs.496544

    UniProtKB/Swiss-Prot: MORC4_HUMAN, Q8TE76
    Tissue specificity: Expressed at low levels in normal tissues, with highest expression levels in placenta and
    testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas

        SABiosciences Custom PCR Arrays for MORC4
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MORC4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MORC4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MORC4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORC4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MORC4 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Morc41 , 5 microrchidia 41, 5 85.94(n)1
    82.42(a)1
      X (61.35 cM)5
    757461  NM_001193309.11  NP_001180238.11 
     1398216325 
    zebrafish
    (Danio rerio)
    Actinopterygii MORC46
    MORC family CW-type zinc finger 4
    57(a)
    1 ↔ 1
    Zv9_NA47(9456-34743)
    worm
    (Caenorhabditis elegans)
    Secernentea morc-16
    Protein MORC-1
    17(a)
    1 → many
    III(5203689-5206911)


    ENSEMBL Gene Tree for MORC4 (if available)
    TreeFam Gene Tree for MORC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MORC4 gene
    MORC22  MORC32  MORC12  
    1 SIMAP similar gene for MORC4 using alignment to 2 protein entries:     MORC4_HUMAN (see all proteins):
    MORC3

    MORC4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/785 SNPs in MORC4 are shown (see all 785)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872454781,2
    --106155302(+) ACCCCC/TCACTC 2 -- ds50010--------
    rs120147621,2
    C,F,H--106155389(+) GAAATT/CCCATT 2 -- ds500118Minor allele frequency- C:0.83NS EA NA 2296
    rs169872251,2
    C,F,H--106155469(+) AATACC/TAAAGC 2 -- ds500111--NA NS EA WA CSA 568
    rs1132657791,2
    C,F--106155525(+) CACCAT/CTTCTA 2 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs1824717581,2
    --106155738(+) TTAATA/GTTGAA 2 -- ut310--------
    rs151231,2
    C--106155763(+) AGGAAG/TATAGG 2 -- ut311Minor allele frequency- T:0.00NA 2
    rs1867566081,2
    --106155795(+) AGTCCC/TACCAC 2 -- ut310--------
    rs1511642641,2
    --106155940(+) ATATCA/TTACAC 2 -- ut310--------
    rs1903780381,2
    C--106156121(+) AGATAA/C/TACAAT 4 -- ut310--------
    rs1391448221,2
    --106156142(+) TCCAGA/GTCATG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MORC4 (106057101 - 106243474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MORC4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv482964CNV Loss15286789
    esv2752312CNV Gain17911159
    nsv519484CNV Gain19592680


    Locus Specific Mutation Databases (LSDB): MORC4
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MORC4
    DNA2.0 Custom Variant and Variant Library Synthesis for MORC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for MORC4:    About MalaCards
    diffuse large b-cell lymphoma    b-cell lymphomas


    MORC4 for disorders           About GeneDecksing


    Export disorders for MORC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MORC4 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with MORC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas. (PubMed id 17608765)1, 2, 9 Liggins A.P....Banham A.H. (2007)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PubMed id 14607086)1, 3 Perry J. and Zhao Y. (2003)
    5. Common genetic variants in the CLDN2 and PRSS1-PRSS2 l oci alter risk for alcohol-related and sporadic pancreatitis. (PubMed id 23143602)1 Whitcomb D.C....Devlin B. (2012)
    6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79710 HGNC: 23485 AceView: ZCWCC2 Ensembl:ENSG00000133131 euGenes: HUgn79710
    ECgene: MORC4 H-InvDB: MORC4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MORC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MORC4 gene:
    Search GeneIP for patents involving MORC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MORC4  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MORC4  
     OriGene qSTAR qPCR primer pairs in human, mouse for MORC4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MORC4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MORC4   OriGene Custom Protein Services for MORC4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MORC4
     QIAGEN SeqTarget long-range PCR primers for resequencing MORC4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MORC4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MORC4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORC4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MORC4
     GenScript Custom Purified and Recombinant Proteins Services for MORC4 GenScript cDNA clones with any tag delivered in your preferred vector for MORC4
     GenScript Custom Assay Services for MORC4 GenScript Custom Superior Antibodies Services for MORC4
     GenScript Custom overexpressing Cell Line Services for MORC4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MORC4 promoter
     Search Chromatin IP Primers for MORC4
     RT2 qPCR Primer Assay in human, mouse, rat MORC4
     Search GNC Networks for MORC4
     SABiosciences Custom PCR Arrays for MORC4
     Search Tocris compounds for MORC4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MORC4 antibodies
     Antibodies for MORC4
     See all of Abcam's Antibodies, Kits and Proteins for MORC4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MORC4
     Antibodies for MORC4
     ELISAs for MORC4
     CLIAs for MORC4
     Search LifeMap BioReagents cell lines for MORC4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORC4
     SwitchGear 3'UTR luciferase reporter plasmids for MORC4
     SwitchGear Promoter luciferase reporter plasmids for MORC4
     Search ThermoFisher Antibodies for MORC4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORC4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MORC4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MORC4
    Customized:
     lentivirus for stable overexpression of MORC4
     lentivirus expression plasmids for stable overexpression of MORC4
     adenovirus for overexpression of MORC4
     Search LSBio for Antibodies for MORC4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MORC4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4