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MORC3 Gene

protein-coding   GIFtS: 51
GCID: GC21P037692

MORC Family CW-Type Zinc Finger 3

(Previous names: zinc finger, CW-type with coiled-coil domain 3, zinc finger,...)
(Previous symbol: ZCWCC3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MORC Family CW-Type Zinc Finger 31 2     NXP22 5
ZCWCC31 2 3     ZCW52
Zinc Finger, CW Type With Coiled-Coil Domain 31 2     MORC Family CW-Type Zinc Finger Protein 32
Zinc Finger, CW-Type With Coiled-Coil Domain 31 2     Nuclear Matrix Protein NXP22
Zinc Finger CW-Type Coiled-Coil Domain Protein 32 3     KIAA01363

External Ids:    HGNC: 235721   Entrez Gene: 235152   Ensembl: ENSG000001592567   OMIM: 6100785   UniProtKB: Q141493   

Export aliases for MORC3 gene to outside databases

Previous GC identifers: GC21P036615 GC21P023168


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MORC3 Gene:
This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and
has a predicted coiled-coil domain. (provided by RefSeq, Jul 2008)

GeneCards Summary for MORC3 Gene:
MORC3 (MORC family CW-type zinc finger 3) is a protein-coding gene. Diseases associated with MORC3 include polymyositis, and alopecia. An important paralog of this gene is MORC2.

Gene Wiki entry for MORC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MORC3 gene promoter:
         E2F-4   E2F-3a   E2F-5   p300   NCX/Ncx   Nkx2-2   Egr-1   E2F-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMORC3 promoter sequence
   Search Chromatin IP Primers for MORC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MORC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.13   Ensembl cytogenetic band:  21q22.12   HGNC cytogenetic band: 21q22.13

MORC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORC3 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P037692:  view genomic region     (about GC identifiers)

Start:
37,692,487 bp from pter      End:
37,758,446 bp from pter
Size:
65,960 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MORC3_HUMAN, Q14149 (See protein sequence)
Recommended Name: MORC family CW-type zinc finger protein 3  
Size: 939 amino acids; 107113 Da
Sequence caution: Sequence=BAA09485.2; Type=Erroneous initiation; Sequence=BAA89432.1; Type=Erroneous initiation;
Secondary accessions: A8KA92 Q9UEZ2

Explore the universe of human proteins at neXtProt for MORC3: NX_Q14149

Explore proteomics data for MORC3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys280, Lys293, Lys377, Lys404, Lys432, Lys710, Lys825, Lys891
  • Modification sites at PhosphoSitePlus

  • See MORC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056173.1  
    ENSEMBL proteins: 
     ENSP00000383333   ENSP00000449467   ENSP00000447562   ENSP00000448357   ENSP00000449966  

    MORC3 Human Recombinant Protein Products:

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    Novus Biologicals MORC3 Lysates
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    Cloud-Clone Corp. Proteins for MORC3

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    Abcam antibodies for MORC3
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    LSBio Antibodies in human, mouse, rat for MORC3

    MORC3 Assay Products:

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    Cloud-Clone Corp. ELISAs for MORC3
    Cloud-Clone Corp. CLIAs for MORC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003594 HATPase_ATP-bd
     IPR011124 Znf_CW

    Graphical View of Domain Structure for InterPro Entry Q14149

    ProtoNet protein and cluster: Q14149

    2 Blocks protein domains:
    IPB003594 ATP-binding region
    IPB011124 CW-type Zn-finger


    UniProtKB/Swiss-Prot: MORC3_HUMAN, Q14149
    Similarity: Contains 1 CW-type zinc finger


    MORC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0008270zinc ion binding IEA--
         
    MORC3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MORC3:
     Increased G2M DNA content, inc  Synthetic lethal with imatinib 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Morc3):
     embryogenesis  mortality/aging 

    MORC3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MORC3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MORC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MORC3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MORC3

    miRNA
    Products:
        
    miRTarBase miRNAs that target MORC3:
    hsa-mir-21-5p (MIRT030797), hsa-mir-101-3p (MIRT027287), hsa-mir-32-5p (MIRT028275), hsa-mir-197-3p (MIRT048085), hsa-mir-155-5p (MIRT020644)

    Block miRNA regulation of human, mouse, rat MORC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MORC3 (see all 16):
    hsa-miR-520d-5p hsa-miR-25 hsa-miR-20b* hsa-miR-4275 hsa-miR-542-3p hsa-miR-3908 hsa-miR-3148 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidMORC3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat MORC3

    Gene Editing
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    OriGene ORF clones in mouse, rat for MORC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MORC3 (NM_015358)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MORC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORC3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MORC3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    mitochondrion2
    cytosol1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm ----
    GO:0016235aggresome ----
    GO:0016605PML body IDA17332504
    GO:0045111intermediate filament cytoskeleton ----

    MORC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including MORC3: 
              Cellular Senescence in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MORC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for MORC3 (ENSP000003833334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO2ENSP000004059654STRING: ENSP00000405965
    UBCENSP000003448184STRING: ENSP00000344818
    RAD23AENSP000003213654STRING: ENSP00000321365
    KPNA2ENSP000003324554STRING: ENSP00000332455
    EEDENSP000002633604STRING: ENSP00000263360
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA17332504
    GO:0007569cell aging IDA17332504
    GO:0009791post-embryonic development IEA--
    GO:0018105peptidyl-serine phosphorylation IDA17332504
    GO:0048147negative regulation of fibroblast proliferation IDA17332504

    MORC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MORC3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MORC3 gene: 
    NM_015358.2  

    Unigene Cluster for MORC3:

    MORC family CW-type zinc finger 3
    Hs.421150  [show with all ESTs]
    Unigene Representative Sequence: NM_015358
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492336 ENST00000400485(uc002yvi.3) ENST00000487909 ENST00000485933
    ENST00000485299 ENST00000484028 ENST00000546482 ENST00000549948 ENST00000551788
    ENST00000551367 ENST00000552581 ENST00000547657
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MORC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MORC3 (see all 16):
    hsa-miR-520d-5p hsa-miR-25 hsa-miR-20b* hsa-miR-4275 hsa-miR-542-3p hsa-miR-3908 hsa-miR-3148 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidMORC3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MORC3
    Predesigned siRNA for gene silencing in human, mouse, rat MORC3
    Clone
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    OriGene clones in human, mouse for MORC3 (see all 7)
    OriGene ORF clones in mouse, rat for MORC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MORC3 (NM_015358)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MORC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORC3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MORC3
    OriGene qSTAR qPCR primer pairs in human, mouse for MORC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MORC3
      QuantiTect SYBR Green Assays in human, mouse, rat MORC3
      QuantiFast Probe-based Assays in human, mouse, rat MORC3

    Additional mRNA sequence: 

    AK025327.1 AK292957.1 AK295133.1 BC007311.1 BC042609.1 BC058002.1 BC094779.1 BC132731.1 
    BC144116.1 D50926.2 

    7 DOTS entries:

    DT.445709  DT.100713994  DT.404045  DT.100020225  DT.121133770  DT.91800440  DT.97787021 

    Selected AceView cDNA sequences (see all 135):

    AI174673 BQ086298 CK903659 AA731639 CK820166 H79433 BM142238 BX098157 
    BE466631 BM454503 BM459928 AI284157 AA319241 BC007311 NM_015358 AW338098 
    BE350814 AI160405 BC042609 BQ102383 BM142262 AA337224 BM800232 AW615142 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MORC3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18
    SP1:                                            -                             -                                         -                                       
    SP2:                                      -     -     -     -     -           -                                                                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for MORC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MORC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAATTTTTT
    MORC3 Expression
    About this image

    MORC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MORC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.421150
        Pathway & Disease-focused RT2 Profiler PCR Array including MORC3: 
              Cellular Senescence in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MORC3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Morc31 , 5 microrchidia 31, 5 82.82(n)1
    83.6(a)1
      16 (54.88 cM)5
    3384671  NM_001045529.31  NP_001038994.21 
     938321215 
    chicken
    (Gallus gallus)
    Aves MORC31 MORC family CW-type zinc finger 3 72.26(n)
    72.26(a)
      418513  NM_001257224.1  NP_001244153.1 
    lizard
    (Anolis carolinensis)
    Reptilia MORC36
    MORC family CW-type zinc finger 3
    65(a)
    1 ↔ 1
    3(141445338-141483572)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.40652 Xenopus laevis transcribed sequence with moderate similarity more 75(n)    BU904373.1 
    zebrafish
    (Danio rerio)
    Actinopterygii morc3a1 MORC family CW-type zinc finger 3a 59.68(n)
    57.31(a)
      553447  NM_001089366.1  NP_001082835.1 
    worm
    (Caenorhabditis elegans)
    Secernentea morc-16
    Protein MORC-1 (morc-1) mRNA, complete cds
    19(a)
    1 → many
    III(5203689-5206911) WBGene00022531


    ENSEMBL Gene Tree for MORC3 (if available)
    TreeFam Gene Tree for MORC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MORC3 gene
    MORC22  MORC42  MORC12  
    1 SIMAP similar gene for MORC3 using alignment to 6 protein entries:     MORC3_HUMAN (see all proteins):
    MORC4

    MORC3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MORC3 (see all 1267)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898749561,2
    --37690546(+) GAGGCA/GGGCGG 1 -- us2k10--------
    rs99790131,2
    C--37690776(+) aaaaaG/Aaaaaa 1 -- us2k1 trp31Minor allele frequency- A:0.00NA 2
    rs99787561,2
    C--37690777(+) aaaagA/Gaaaaa 1 -- us2k1 trp31Minor allele frequency- G:0.00NA 2
    rs354270651,2
    C--37690777(+) AAAAG-/AAAAAA 1 -- us2k10--------
    rs1153808561,2
    C,F--37690794(+) ATTCTC/TTTTTG 1 -- us2k11Minor allele frequency- T:0.11WA 118
    rs1439043441,2
    C--37690863(+) TGAGAA/TCATGG 1 -- us2k10--------
    rs1468926451,2
    C--37690885(+) CTCAGC/TCTCCC 1 -- us2k10--------
    rs2186211,2
    C--37691007(-) cagccC/Gggaca 1 -- us2k14Minor allele frequency- G:0.14NA WA CSA 7
    rs1826082371,2
    --37691074(+) TTCTCC/TTGCCT 1 -- us2k10--------
    rs1410015371,2
    C--37691159(+) GGTTTC/TGCCAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MORC3 (37692487 - 37758446 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MORC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671533CNV Deletion23128226
    esv2659831CNV Deletion23128226
    esv33578CNV Loss17666407
    nsv3505CNV Loss18451855
    nsv913734CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MORC3
    DNA2.0 Custom Variant and Variant Library Synthesis for MORC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610078    OMIM disorders: --

    6 diseases for MORC3:    About MalaCards
    polymyositis    alopecia    dermatomyositis    myopathy
    lymphoblastic leukemia    leukemia


    MORC3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MORC3

    Export disorders for MORC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MORC3 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with MORC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PubMed id 14607086)1, 3 Perry J. and Zhao Y. (Trends Biochem. Sci. 2003)
    3. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    4. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T.... Nomura N. (DNA Res. 1995)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1I^. (PubMed id 24037894)1 Fiorentino D.F....Casciola-Rosen L. (Arthritis Rheum. 2013)
    7. Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis. (PubMed id 22546500)1 Ceribelli A....Satoh M. (amp 2012)
    8. Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy. (PubMed id 22258483)1 Ichimura Y....Fujimoto M. (Ann. Rheum. Dis. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23515 HGNC: 23572 AceView: ZCWCC3 Ensembl:ENSG00000159256 euGenes: HUgn23515
    ECgene: MORC3 H-InvDB: MORC3

    (According to HUGE)
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    HUGE: KIAA0136

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MORC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MORC3 gene:
    Search GeneIP for patents involving MORC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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