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Aliases for MORC3 Gene

Aliases for MORC3 Gene

  • MORC Family CW-Type Zinc Finger 3 2 3
  • Zinc Finger CW-Type Coiled-Coil Domain Protein 3 3 4
  • Zinc Finger, CW-Type With Coiled-Coil Domain 3 2 3
  • Zinc Finger, CW Type With Coiled-Coil Domain 3 2 3
  • ZCWCC3 3 4
  • NXP2 3 6
  • MORC Family CW-Type Zinc Finger Protein 3 3
  • Nuclear Matrix Protein NXP2 3
  • KIAA0136 4
  • ZCW5 3

External Ids for MORC3 Gene

Previous HGNC Symbols for MORC3 Gene

  • ZCWCC3

Previous GeneCards Identifiers for MORC3 Gene

  • GC21P036615
  • GC21P037692
  • GC21P023168

Summaries for MORC3 Gene

Entrez Gene Summary for MORC3 Gene

  • This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and has a predicted coiled-coil domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for MORC3 Gene

MORC3 (MORC Family CW-Type Zinc Finger 3) is a Protein Coding gene. An important paralog of this gene is MORC2.

Gene Wiki entry for MORC3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORC3 Gene

Genomics for MORC3 Gene

Regulatory Elements for MORC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MORC3 Gene

Start:
36,320,189 bp from pter
End:
36,386,148 bp from pter
Size:
65,960 bases
Orientation:
Plus strand

Genomic View for MORC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MORC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORC3 Gene

Proteins for MORC3 Gene

  • Protein details for MORC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14149-MORC3_HUMAN
    Recommended name:
    MORC family CW-type zinc finger protein 3
    Protein Accession:
    Q14149
    Secondary Accessions:
    • A8KA92
    • Q9UEZ2

    Protein attributes for MORC3 Gene

    Size:
    939 amino acids
    Molecular mass:
    107113 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA09485.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA89432.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MORC3 Gene

neXtProt entry for MORC3 Gene

Proteomics data for MORC3 Gene at MOPED

Post-translational modifications for MORC3 Gene

  • Ubiquitination at Lys280, Lys293, Lys377, Lys404, Lys432, Lys710, Lys825, and Lys891
  • Modification sites at PhosphoSitePlus

Other Protein References for MORC3 Gene

No data available for DME Specific Peptides for MORC3 Gene

Domains for MORC3 Gene

Protein Domains for MORC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q14149

UniProtKB/Swiss-Prot:

MORC3_HUMAN :
  • Q14149
Similarity:
  • Contains 1 CW-type zinc finger.
genes like me logo Genes that share domains with MORC3: view

No data available for Gene Families for MORC3 Gene

Function for MORC3 Gene

Gene Ontology (GO) - Molecular Function for MORC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MORC3: view

Phenotypes for MORC3 Gene

genes like me logo Genes that share phenotypes with MORC3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MORC3 Gene

Localization for MORC3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MORC3 Gene COMPARTMENTS Subcellular localization image for MORC3 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MORC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0016605 PML body IDA 17332504
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with MORC3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MORC3 Gene

Pathways for MORC3 Gene

SuperPathways for MORC3 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for MORC3 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000383333%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000405965%0d%0a9606.ENSP00000360120%0d%0a9606.ENSP00000343701%0d%0a
Selected Interacting proteins: ENSP00000383333 for MORC3 Gene via STRING

Gene Ontology (GO) - Biological Process for MORC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 17332504
GO:0007569 cell aging IDA 17332504
GO:0009791 post-embryonic development IEA --
GO:0018105 peptidyl-serine phosphorylation IDA 17332504
GO:0048147 negative regulation of fibroblast proliferation IDA 17332504
genes like me logo Genes that share ontologies with MORC3: view

No data available for Pathways by source for MORC3 Gene

Transcripts for MORC3 Gene

Unigene Clusters for MORC3 Gene

MORC family CW-type zinc finger 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MORC3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MORC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18
SP1: - - -
SP2: - - - - - -
SP3:
SP4:
SP5:

Relevant External Links for MORC3 Gene

GeneLoc Exon Structure for
MORC3
ECgene alternative splicing isoforms for
MORC3

Expression for MORC3 Gene

mRNA expression in normal human tissues for MORC3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MORC3 Gene

SOURCE GeneReport for Unigene cluster for MORC3 Gene Hs.421150

genes like me logo Genes that share expressions with MORC3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MORC3 Gene

Orthologs for MORC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MORC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MORC3 35
  • 99.75 (n)
  • 99.68 (a)
MORC3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MORC3 35
  • 87.92 (n)
  • 86.99 (a)
MORC3 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MORC3 35
  • 90.26 (n)
  • 90.62 (a)
MORC3 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Morc3 35
  • 82.82 (n)
  • 83.6 (a)
Morc3 16
Morc3 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MORC3 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MORC3 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Morc3 35
  • 81.24 (n)
  • 81.04 (a)
chicken
(Gallus gallus)
Aves MORC3 35
  • 72.26 (n)
  • 72.26 (a)
MORC3 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MORC3 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4065 35
tropical clawed frog
(Silurana tropicalis)
Amphibia morc3 35
  • 61.98 (n)
  • 60.94 (a)
Str.11041 35
zebrafish
(Danio rerio)
Actinopterygii morc3a 35
  • 59.68 (n)
  • 57.31 (a)
morc3a 36
  • 41 (a)
OneToMany
morc3b 36
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea morc-1 36
  • 19 (a)
OneToMany
Species with no ortholog for MORC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MORC3 Gene

ENSEMBL:
Gene Tree for MORC3 (if available)
TreeFam:
Gene Tree for MORC3 (if available)

Paralogs for MORC3 Gene

Paralogs for MORC3 Gene

Selected SIMAP similar genes for MORC3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MORC3: view

Variants for MORC3 Gene

Sequence variations from dbSNP and Humsavar for MORC3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs9108 -- 36,376,454(+) ATATA(C/T)AGTAT utr-variant-3-prime
rs218620 -- 36,346,449(-) cacac(A/G)aagca intron-variant
rs218621 -- 36,318,709(-) cagcc(C/G)ggaca upstream-variant-2KB
rs218622 -- 36,351,252(-) atctc(C/T)accaa intron-variant
rs1063308 -- 36,375,309(+) GTTAT(A/G)TAAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MORC3 Gene

Variant ID Type Subtype PubMed ID
esv33578 CNV Loss 17666407
nsv913734 CNV Gain 21882294
esv2659831 CNV Deletion 23128226
esv2671533 CNV Deletion 23128226
nsv3505 CNV Loss 18451855

Relevant External Links for MORC3 Gene

HapMap Linkage Disequilibrium report
MORC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MORC3 Gene

Disorders for MORC3 Gene

Relevant External Links for MORC3

Genetic Association Database (GAD)
MORC3
genes like me logo Genes that share disorders with MORC3: view

No data available for UniProtKB/Swiss-Prot for MORC3 Gene

Publications for MORC3 Gene

  1. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PMID: 14607086) Perry J. … Zhao Y. (Trends Biochem. Sci. 2003) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 3 4
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  5. The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains. (PMID: 11927593) Kimura Y. … Osumi T. (J. Biol. Chem. 2002) 3

Products for MORC3 Gene

Sources for MORC3 Gene

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