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Aliases for MORC3 Gene

Aliases for MORC3 Gene

  • MORC Family CW-Type Zinc Finger 3 2 3 5
  • Zinc Finger CW-Type Coiled-Coil Domain Protein 3 3 4
  • Zinc Finger, CW-Type With Coiled-Coil Domain 3 2 3
  • Zinc Finger, CW Type With Coiled-Coil Domain 3 2 3
  • Nuclear Matrix Protein 2 3 4
  • ZCWCC3 3 4
  • NXP2 3 4
  • Nuclear Matrix Protein NXP2 3
  • KIAA0136 4
  • ZCW5 3

External Ids for MORC3 Gene

Previous HGNC Symbols for MORC3 Gene

  • ZCWCC3

Previous GeneCards Identifiers for MORC3 Gene

  • GC21P036615
  • GC21P037692
  • GC21P023168

Summaries for MORC3 Gene

Entrez Gene Summary for MORC3 Gene

  • This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]

GeneCards Summary for MORC3 Gene

MORC3 (MORC Family CW-Type Zinc Finger 3) is a Protein Coding gene. Diseases associated with MORC3 include Dermatomyositis and Childhood Type Dermatomyositis. An important paralog of this gene is MORC4.

UniProtKB/Swiss-Prot for MORC3 Gene

  • Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233).

Gene Wiki entry for MORC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORC3 Gene

Genomics for MORC3 Gene

Regulatory Elements for MORC3 Gene

Enhancers for MORC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MORC3 on UCSC Golden Path with GeneCards custom track

Promoters for MORC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MORC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MORC3 Gene

Chromosome:
21
Start:
36,320,189 bp from pter
End:
36,386,148 bp from pter
Size:
65,960 bases
Orientation:
Plus strand

Genomic View for MORC3 Gene

Genes around MORC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORC3 Gene

Proteins for MORC3 Gene

  • Protein details for MORC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14149-MORC3_HUMAN
    Recommended name:
    MORC family CW-type zinc finger protein 3
    Protein Accession:
    Q14149
    Secondary Accessions:
    • A8KA92
    • Q9UEZ2

    Protein attributes for MORC3 Gene

    Size:
    939 amino acids
    Molecular mass:
    107113 Da
    Quaternary structure:
    • Homodimer (PubMed:17332504). The sumoylated form interacts with PML (via SUMO-interacting motif) (PubMed:20501696, PubMed:17332504). Interacts with PT53 (PubMed:17332504). Interacts with influenza A virus PA and PB1 polymerase subunits during infection (PubMed:26202233).
    SequenceCaution:
    • Sequence=BAA09485.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA89432.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MORC3 Gene

neXtProt entry for MORC3 Gene

Proteomics data for MORC3 Gene at MOPED

Post-translational modifications for MORC3 Gene

  • Sumoylation is involved in interaction with PML and localization to PML nuclear bodies.
  • Ubiquitination at Lys 280, Lys 293, Lys 377, Lys 404, Lys 432, Lys 710, Lys 825, and Lys 891
  • Modification sites at PhosphoSitePlus

Other Protein References for MORC3 Gene

No data available for DME Specific Peptides for MORC3 Gene

Domains & Families for MORC3 Gene

Gene Families for MORC3 Gene

Protein Domains for MORC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q14149

UniProtKB/Swiss-Prot:

MORC3_HUMAN :
  • Contains 1 CW-type zinc finger.
Similarity:
  • Contains 1 CW-type zinc finger.
genes like me logo Genes that share domains with MORC3: view

Function for MORC3 Gene

Molecular function for MORC3 Gene

UniProtKB/Swiss-Prot Function:
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233).
genes like me logo Genes that share phenotypes with MORC3: view

Animal Models for MORC3 Gene

MGI Knock Outs for MORC3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MORC3 Gene

Localization for MORC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MORC3 Gene

Nucleus, nucleoplasm. Nucleus matrix. Nucleus, PML body. Note=Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent. {ECO:0000269 PubMed:20501696}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MORC3 Gene COMPARTMENTS Subcellular localization image for MORC3 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MORC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016605 PML body IEA,IDA 17332504
genes like me logo Genes that share ontologies with MORC3: view

Pathways & Interactions for MORC3 Gene

SuperPathways for MORC3 Gene

No Data Available

Interacting Proteins for MORC3 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000383333%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000405965%0d%0a9606.ENSP00000360120%0d%0a9606.ENSP00000343701%0d%0a
Selected Interacting proteins: ENSP00000383333 for MORC3 Gene via STRING

Gene Ontology (GO) - Biological Process for MORC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 17332504
GO:0007569 cell aging IDA 17332504
GO:0018105 peptidyl-serine phosphorylation IDA 17332504
GO:0048147 negative regulation of fibroblast proliferation IDA 17332504
GO:0050821 protein stabilization IDA 17332504
genes like me logo Genes that share ontologies with MORC3: view

No data available for Pathways by source and SIGNOR curated interactions for MORC3 Gene

Drugs & Compounds for MORC3 Gene

No Compound Related Data Available

Transcripts for MORC3 Gene

Unigene Clusters for MORC3 Gene

MORC family CW-type zinc finger 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MORC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18
SP1: - - -
SP2: - - - - - -
SP3:
SP4:
SP5:

Relevant External Links for MORC3 Gene

GeneLoc Exon Structure for
MORC3
ECgene alternative splicing isoforms for
MORC3

Expression for MORC3 Gene

mRNA expression in normal human tissues for MORC3 Gene

Protein differential expression in normal tissues from HIPED for MORC3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.9), Plasma (8.7), and Monocytes (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MORC3 Gene



SOURCE GeneReport for Unigene cluster for MORC3 Gene Hs.421150

mRNA Expression by UniProt/SwissProt for MORC3 Gene

Q14149-MORC3_HUMAN
Tissue specificity: Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney.
genes like me logo Genes that share expression patterns with MORC3: view

Protein tissue co-expression partners for MORC3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MORC3 Gene

Orthologs for MORC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MORC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MORC3 35
  • 87.92 (n)
  • 86.99 (a)
MORC3 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MORC3 35
  • 90.26 (n)
  • 90.62 (a)
MORC3 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Morc3 35
  • 82.82 (n)
  • 83.6 (a)
Morc3 16
Morc3 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MORC3 35
  • 99.75 (n)
  • 99.68 (a)
MORC3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Morc3 35
  • 81.24 (n)
  • 81.04 (a)
oppossum
(Monodelphis domestica)
Mammalia MORC3 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MORC3 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves MORC3 35
  • 72.26 (n)
  • 72.26 (a)
MORC3 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MORC3 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia morc3 35
  • 61.98 (n)
  • 60.94 (a)
Str.11041 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4065 35
zebrafish
(Danio rerio)
Actinopterygii morc3a 35
  • 59.68 (n)
  • 57.31 (a)
morc3a 36
  • 41 (a)
OneToMany
morc3b 36
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea morc-1 36
  • 19 (a)
OneToMany
Species with no ortholog for MORC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MORC3 Gene

ENSEMBL:
Gene Tree for MORC3 (if available)
TreeFam:
Gene Tree for MORC3 (if available)

Paralogs for MORC3 Gene

Paralogs for MORC3 Gene

(1) SIMAP similar genes for MORC3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MORC3: view

Variants for MORC3 Gene

Sequence variations from dbSNP and Humsavar for MORC3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2282106 -- 36,321,545(+) CTTTT(A/T)TTCTT intron-variant, upstream-variant-2KB
rs2282107 -- 36,335,283(+) ATCAT(A/C)GATGG intron-variant
rs2282108 -- 36,335,470(+) gccac(C/T)gctcc intron-variant
rs2297254 -- 36,338,517(+) ACCCT(A/G)TCTCT intron-variant
rs4816530 -- 36,327,943(+) atgat(C/G)ttggc intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MORC3 Gene

Variant ID Type Subtype PubMed ID
esv33578 CNV Loss 17666407
nsv913734 CNV Gain 21882294
esv2659831 CNV Deletion 23128226
esv2671533 CNV Deletion 23128226
nsv3505 CNV Loss 18451855

Variation tolerance for MORC3 Gene

Residual Variation Intolerance Score: 11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MORC3 Gene

Disorders for MORC3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MORC3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dermatomyositis
  • amyopathic dermatomyositis
childhood type dermatomyositis
  • childhood dermatomyositis
- elite association - COSMIC cancer census association via MalaCards
Search MORC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MORC3

Genetic Association Database (GAD)
MORC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MORC3
genes like me logo Genes that share disorders with MORC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MORC3 Gene

Publications for MORC3 Gene

  1. The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication. (PMID: 26202233) Ver L.S. … Ortin J. (J. Virol. 2015) 3 4 67
  2. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PMID: 14607086) Perry J. … Zhao Y. (Trends Biochem. Sci. 2003) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Interstitial lung disease in an adult patient with dermatomyositis and anti-NXP2 autoantibody. (PMID: 26028648) Gossez M. … Fabien N. (Eur Respir Rev 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for MORC3 Gene

Sources for MORC3 Gene

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