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Aliases for MORC2 Gene

Aliases for MORC2 Gene

  • MORC Family CW-Type Zinc Finger 2 2 3 5
  • Zinc Finger CW-Type Coiled-Coil Domain Protein 1 3 4
  • ZCWCC1 3 4
  • Zinc Finger, CW-Type With Coiled-Coil Domain 1 2
  • Zinc Finger, CW Type With Coiled-Coil Domain 1 2
  • MORC Family CW-Type Zinc Finger Protein 2 3
  • KIAA0852 4
  • CMT2Z 3
  • ZCW3 3

External Ids for MORC2 Gene

Previous HGNC Symbols for MORC2 Gene

  • ZCWCC1

Previous GeneCards Identifiers for MORC2 Gene

  • GC22M029651
  • GC22M031322
  • GC22M014286

Summaries for MORC2 Gene

Entrez Gene Summary for MORC2 Gene

  • This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

GeneCards Summary for MORC2 Gene

MORC2 (MORC Family CW-Type Zinc Finger 2) is a Protein Coding gene. Diseases associated with MORC2 include Charcot-Marie-Tooth Disease, Axonal, Type 2Z and Charcot-Marie-Tooth Disease. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is MORC1.

UniProtKB/Swiss-Prot for MORC2 Gene

  • Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). May act as a transcriptional repressor (PubMed:20225202). Down-regulates CA9 expression (PubMed:20110259).

Gene Wiki entry for MORC2 Gene

Additional gene information for MORC2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORC2 Gene

Genomics for MORC2 Gene

Regulatory Elements for MORC2 Gene

Enhancers for MORC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H030234 2 FANTOM5 Ensembl ENCODE dbSUPER 46.4 +721.8 721767 24 PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B ZNF416 ZNF143 FOS SP5 REST TUG1 SF3A1 EWSR1 MORC2 PES1 RNF215 TBC1D10A THOC5 HORMAD2-AS1 LIF
GH22H031097 1.6 Ensembl ENCODE dbSUPER 30.4 -134.6 -134555 10 PKNOX1 FOXA2 ARNT ARID4B YY1 ZNF143 FOS DEK SP3 SP5 TUG1 MORC2 RNF185 SELENOM EIF4ENIF1 PATZ1 RNF215 PLA2G3 ENSG00000214125 DEPDC5
GH22H031077 1.6 Ensembl ENCODE dbSUPER 23.5 -114.4 -114401 10 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 TUG1 MORC2 SELENOM SMTN SF3A1 INPP5J TBC1D10A PRR14L PES1 DEPDC5
GH22H031159 1.1 ENCODE 33.1 -192.2 -192154 2 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 TUG1 MORC2 SF3A1 PES1 PRR14L DEPDC5 TBC1D10A LOC91370 RPS17P16 SFI1
GH22H031658 1.4 ENCODE dbSUPER 25.6 -692.6 -692550 5 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 TUG1 RTCB MORC2 PRR14L DEPDC5 RNF185 RPS17P16 EIF4ENIF1 ENSG00000240591 PISD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MORC2 on UCSC Golden Path with GeneCards custom track

Promoters for MORC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000145288 -803 2201 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF143

Genomic Location for MORC2 Gene

Chromosome:
22
Start:
30,925,130 bp from pter
End:
30,968,497 bp from pter
Size:
43,368 bases
Orientation:
Minus strand

Genomic View for MORC2 Gene

Genes around MORC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORC2 Gene

Proteins for MORC2 Gene

  • Protein details for MORC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6X9-MORC2_HUMAN
    Recommended name:
    MORC family CW-type zinc finger protein 2
    Protein Accession:
    Q9Y6X9
    Secondary Accessions:
    • B2RNB1
    • Q9UF28
    • Q9Y6V2

    Protein attributes for MORC2 Gene

    Size:
    1032 amino acids
    Molecular mass:
    117823 Da
    Quaternary structure:
    • Interacts with HDAC4 (PubMed:20110259). Interacts with ACLY (PubMed:24286864).
    SequenceCaution:
    • Sequence=AAC12954.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA74875.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for MORC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MORC2 Gene

Post-translational modifications for MORC2 Gene

  • Ubiquitination at Lys932
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MORC2 Gene

Domains & Families for MORC2 Gene

Gene Families for MORC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MORC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MORC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MORC2: view

No data available for UniProtKB/Swiss-Prot for MORC2 Gene

Function for MORC2 Gene

Molecular function for MORC2 Gene

UniProtKB/Swiss-Prot Function:
Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). May act as a transcriptional repressor (PubMed:20225202). Down-regulates CA9 expression (PubMed:20110259).

Phenotypes From GWAS Catalog for MORC2 Gene

Gene Ontology (GO) - Molecular Function for MORC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MORC2: view

Phenotypes for MORC2 Gene

genes like me logo Genes that share phenotypes with MORC2: view

Human Phenotype Ontology for MORC2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MORC2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MORC2 Gene

Localization for MORC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MORC2 Gene

Nucleus. Cytoplasm, cytosol. Note=Mainly located in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MORC2 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MORC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,IEA --
genes like me logo Genes that share ontologies with MORC2: view

Pathways & Interactions for MORC2 Gene

SuperPathways for MORC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MORC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
genes like me logo Genes that share ontologies with MORC2: view

No data available for Pathways by source and SIGNOR curated interactions for MORC2 Gene

Drugs & Compounds for MORC2 Gene

No Compound Related Data Available

Transcripts for MORC2 Gene

Unigene Clusters for MORC2 Gene

MORC family CW-type zinc finger 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MORC2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MORC2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1:
SP2: - -
SP3:

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27a · 27b
SP1:
SP2:
SP3: -

Relevant External Links for MORC2 Gene

GeneLoc Exon Structure for
MORC2
ECgene alternative splicing isoforms for
MORC2

Expression for MORC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MORC2 Gene

Protein differential expression in normal tissues from HIPED for MORC2 Gene

This gene is overexpressed in Kidney (21.0), Liver (13.3), and Adrenal (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MORC2 Gene



NURSA nuclear receptor signaling pathways regulating expression of MORC2 Gene:

MORC2

SOURCE GeneReport for Unigene cluster for MORC2 Gene:

Hs.555918

mRNA Expression by UniProt/SwissProt for MORC2 Gene:

Q9Y6X9-MORC2_HUMAN
Tissue specificity: Highly expressed in smooth muscle, pancreas and testis.

Evidence on tissue expression from TISSUES for MORC2 Gene

  • Nervous system(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with MORC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MORC2 Gene

Orthologs for MORC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MORC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MORC2 33 34
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia MORC2 33 34
  • 90.96 (n)
cow
(Bos Taurus)
Mammalia MORC2 33 34
  • 89.31 (n)
rat
(Rattus norvegicus)
Mammalia Morc2 33
  • 86.76 (n)
mouse
(Mus musculus)
Mammalia Morc2a 33 16 34
  • 86.64 (n)
Morc2b 34
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MORC2 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MORC2 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves MORC2 33 34
  • 74.28 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
OneToMany
-- 34
  • 71 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia morc2 33
  • 66.55 (n)
Str.10569 33
zebrafish
(Danio rerio)
Actinopterygii morc2 33 34
  • 63.48 (n)
worm
(Caenorhabditis elegans)
Secernentea morc-1 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 59 (a)
OneToOne
Species where no ortholog for MORC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MORC2 Gene

ENSEMBL:
Gene Tree for MORC2 (if available)
TreeFam:
Gene Tree for MORC2 (if available)

Paralogs for MORC2 Gene

Paralogs for MORC2 Gene

(1) SIMAP similar genes for MORC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MORC2: view

Variants for MORC2 Gene

Sequence variations from dbSNP and Humsavar for MORC2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs749060708 Charcot-Marie-Tooth disease 2Z (CMT2Z) [MIM:616688] 30,949,783(+) AATCT(C/G)AGTAG reference, missense
rs864309503 Pathogenic, Charcot-Marie-Tooth disease 2Z (CMT2Z) [MIM:616688] 30,941,503(-) ATCCC(C/T)GGATG reference, missense
rs864309504 Pathogenic, Charcot-Marie-Tooth disease 2Z (CMT2Z) [MIM:616688] 30,949,809(-) GAAGT(C/T)GGCCA reference, missense
VAR_076456 Charcot-Marie-Tooth disease 2Z (CMT2Z) [MIM:616688]
VAR_076460 Charcot-Marie-Tooth disease 2Z (CMT2Z) [MIM:616688]

Structural Variations from Database of Genomic Variants (DGV) for MORC2 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259

Variation tolerance for MORC2 Gene

Residual Variation Intolerance Score: 2.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MORC2 Gene

Human Gene Mutation Database (HGMD)
MORC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MORC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MORC2 Gene

Disorders for MORC2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MORC2 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, axonal, type 2z
  • charcot-marie-tooth disease axonal type 2z
charcot-marie-tooth disease
  • charcot marie tooth muscular atrophy
tooth disease
  • dental disorder
charcot-marie-tooth disease, type 2e
  • charcot-marie-tooth disease, type 2y
- elite association - COSMIC cancer census association via MalaCards
Search MORC2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MORC2_HUMAN
  • Charcot-Marie-Tooth disease 2Z (CMT2Z) [MIM:616688]: An autosomal dominant, axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. {ECO:0000269 PubMed:26497905, ECO:0000269 PubMed:26659848}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MORC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MORC2
genes like me logo Genes that share disorders with MORC2: view

No data available for Genatlas for MORC2 Gene

Publications for MORC2 Gene

  1. MORC2 mutations cause axonal Charcot-Marie-Tooth disease with pyramidal signs. (PMID: 26659848) Albulym OM … Nicholson GA (Annals of neurology 2016) 3 4 60
  2. Mutations in the MORC2 gene cause axonal Charcot-Marie-Tooth disease. (PMID: 26497905) Sevilla T … Espinós C (Brain : a journal of neurology 2016) 3 4 60
  3. Cytosolic functions of MORC2 in lipogenesis and adipogenesis. (PMID: 24286864) Sánchez-Solana B … Kumar R (Biochimica et biophysica acta 2014) 3 4 60
  4. Identification and expression analysis of a novel CW-type zinc finger protein MORC2 in cancer cells. (PMID: 20225202) Wang GL … Li F (Anatomical record (Hoboken, N.J. : 2007) 2010) 3 4 60
  5. Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX. (PMID: 20110259) Shao Y … Li F (Nucleic acids research 2010) 3 4 60

Products for MORC2 Gene

Sources for MORC2 Gene

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