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MORC2 Gene

protein-coding   GIFtS: 50
GCID: GC22M031322

MORC Family CW-Type Zinc Finger 2

(Previous names: zinc finger, CW-type with coiled-coil domain 1, zinc finger,...)
(Previous symbol: ZCWCC1)
  Search for MORC2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MORC Family CW-Type Zinc Finger 21 2     Zinc Finger CW-Type Coiled-Coil Domain Protein 12 3
ZCWCC11 2 3     ZCW32
Zinc Finger, CW Type With Coiled-Coil Domain 11 2     MORC Family CW-Type Zinc Finger Protein 22
Zinc Finger, CW-Type With Coiled-Coil Domain 11 2     KIAA08523

External Ids:    HGNC: 235731   Entrez Gene: 228802   Ensembl: ENSG000001334227   UniProtKB: Q9Y6X93   

Export aliases for MORC2 gene to outside databases

Previous GC identifers: GC22M029651 GC22M014286


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MORC2 Gene:
MORC2 (MORC family CW-type zinc finger 2) is a protein-coding gene. An important paralog of this gene is MORC3.

UniProtKB/Swiss-Prot: MORC2_HUMAN, Q9Y6X9
Function: May act as a transcriptional repressor. Down-regulates CA9 expression

Gene Wiki entry for MORC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MORC2 gene promoter:
         NF-1/L   NF-1   CP2   Pax-2   RelA   Pax-2a   Nkx2-5   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MORC2 promoter sequence
   Search Chromatin IP Primers for MORC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MORC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

MORC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORC2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M031322:  view genomic region     (about GC identifiers)

Start:
31,321,117 bp from pter      End:
31,364,284 bp from pter
Size:
43,168 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MORC2_HUMAN, Q9Y6X9 (See protein sequence)
Recommended Name: MORC family CW-type zinc finger protein 2  
Size: 1032 amino acids; 117823 Da
Subunit: Interacts with HDAC4
Sequence caution: Sequence=AAC12954.1; Type=Erroneous gene model prediction; Sequence=BAA74875.2;
Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: B2RNB1 Q9UF28 Q9Y6V2
Alternative splicing: 2 isoforms:  Q9Y6X9-1   Q9Y6X9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MORC2: NX_Q9Y6X9

Explore proteomics data for MORC2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys932
  • Modification sites at PhosphoSitePlus

  • See MORC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055756.1  
    ENSEMBL proteins: 
     ENSP00000380763   ENSP00000412685   ENSP00000402602   ENSP00000215862  

    MORC2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003594 HATPase_ATP-bd
     IPR011124 Znf_CW

    Graphical View of Domain Structure for InterPro Entry Q9Y6X9

    ProtoNet protein and cluster: Q9Y6X9

    1 Blocks protein domain: IPB011124 CW-type Zn-finger

    UniProtKB/Swiss-Prot: MORC2_HUMAN, Q9Y6X9
    Similarity: Contains 1 CW-type zinc finger


    MORC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MORC2_HUMAN, Q9Y6X9
    Function: May act as a transcriptional repressor. Down-regulates CA9 expression

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0008270zinc ion binding IEA--
    GO:0030246carbohydrate binding ----
         
    MORC2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MORC2:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MORC2
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    miRNA
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    miRTarBase miRNAs that target MORC2:
    hsa-mir-125a-5p (MIRT045739), hsa-mir-615-3p (MIRT039847)

    Block miRNA regulation of human, mouse, rat MORC2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MORC2:
    hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidMORC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MORC2
    Predesigned siRNA for gene silencing in human, mouse, rat MORC2

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORC2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MORC2_HUMAN, Q9Y6X9: Nucleus. Cytoplasm, cytosol. Note=Mainly located in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--

    MORC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MORC2
    Interactions:

        Search GeneGlobe Interaction Network for MORC2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for MORC2 (Q9Y6X93 ENSP000002158624) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC4P565243, ENSP000002646064I2D: score=1 STRING: ENSP00000264606
    NCOA3Q9Y6Q93, ENSP000003610664I2D: score=1 STRING: ENSP00000361066
    SUMO2ENSP000004059654STRING: ENSP00000405965
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MORC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MORC2 gene: 
    NM_014941.1  

    Unigene Cluster for MORC2:

    MORC family CW-type zinc finger 2
    Hs.555918  [show with all ESTs]
    Unigene Representative Sequence: AB020659
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397641 ENST00000429468 ENST00000445980 ENST00000215862(uc003aje.1)
    ENST00000469915 ENST00000476152
    miRNA
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    Block miRNA regulation of human, mouse, rat MORC2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MORC2:
    hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidMORC2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MORC2
    Predesigned siRNA for gene silencing in human, mouse, rat MORC2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MORC2
      QuantiTect SYBR Green Assays in human, mouse, rat MORC2
      QuantiFast Probe-based Assays in human, mouse, rat MORC2

    Additional mRNA sequence: 

    AB020659.1 AL133637.1 AY236964.1 BC019257.1 BC136782.1 CR456469.1 

    9 DOTS entries:

    DT.100745725  DT.445979  DT.100027705  DT.100745726  DT.100687928  DT.100745727  DT.100643282  DT.100694589 
    DT.75101604 

    Selected AceView cDNA sequences (see all 150):

    AA480159 AI281226 CA426876 BM846374 BQ640129 BQ576129 AA846534 AW276421 
    BX109736 CN482341 BU584680 AB020659 BU838928 BU739709 AA594487 AI912418 
    BQ006828 BM698298 AI476582 BU733868 BQ892777 BU739401 CR456469 AI419948 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MORC2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                                                                                                                                                            
    SP2:              -     -                                                                                                                                       
    SP3:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26a · 26b ^ 27a · 27b
    SP1:                                    
    SP2:                                    
    SP3:                    -               


    ECgene alternative splicing isoforms for MORC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MORC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTGGTGGT
    MORC2 Expression
    About this image

    MORC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MORC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.555918

    UniProtKB/Swiss-Prot: MORC2_HUMAN, Q9Y6X9
    Tissue specificity: Highly expressed in smooth muscle, pancreas and testis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MORC2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Morc2a1 , 5 microrchidia 2A1, 5 86.64(n)1
    90.5(a)1
      11 (2.56 cM)5
    745221  NM_001159288.11  NP_001152760.11 
     36497595 
    chicken
    (Gallus gallus)
    Aves MORC21 MORC family CW-type zinc finger 2 74.28(n)
    78.51(a)
      100858829  XM_004934417.1  XP_004934474.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    72(a)
    71(a)
    1 ↔ many
    1 ↔ many
    5(150133853-150135713)
    GL343417.1(252126-268798)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.105692 Transcribed sequence with moderate similarity to protein more 76.17(n)    BX688066.1 
    zebrafish
    (Danio rerio)
    Actinopterygii morc21 MORC family CW-type zinc finger 2 63.48(n)
    67(a)
      445488  NM_001003994.1  NP_001003994.1 
    worm
    (Caenorhabditis elegans)
    Secernentea morc-16
    Protein MORC-1 (morc-1) mRNA, complete cds
    20(a)
    1 → many
    III(5203689-5206911) WBGene00022531


    ENSEMBL Gene Tree for MORC2 (if available)
    TreeFam Gene Tree for MORC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MORC2 gene
    MORC32  MORC42  MORC12  
    1 SIMAP similar gene for MORC2 using alignment to 3 protein entries:     MORC2_HUMAN (see all proteins):
    MORC1

    MORC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MORC2 (see all 766)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1461448691,2
    --14284776(+) CAGGAC/GCAACT 1 -- ds50010--------
    rs1822787761,2
    --14284888(+) GGGGAA/CGTCTC 1 -- ds50010--------
    rs1118519031,2
    C,F--14284945(+) GTCAGC/TCCTGC 1 -- ds50012Minor allele frequency- T:0.05CSA WA 119
    rs1401895441,2
    --14285025(+) GGCTTA/GGCAAC 1 -- ds50010--------
    rs1889250711,2
    --14285126(+) GCACAA/GCATCT 1 -- ds50010--------
    rs1931364481,2
    --14285235(+) GGTGCA/GACCAC 1 -- ut310--------
    rs1134718631,2
    C--14285266(+) CTCCCA/CCTGCA 1 -- ut310--------
    rs1998019961,2
    --14285338(+) TTGGTA/GATGAG 2 I syn10--------
    rs1491107601,2
    F--14285341(+) GTGATG/AAGGTC 2 /L syn11Minor allele frequency- A:0.00NA 4552
    rs123300401,2
    H--14285358(+) GTAGGC/GGTCCA 2 P A mis1 ese34Minor allele frequency- G:0.00NS EA 394

    HapMap Linkage Disequilibrium report for MORC2 (31321117 - 31364284 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MORC2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MORC2
    DNA2.0 Custom Variant and Variant Library Synthesis for MORC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MORC2 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with MORC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Involvement of histone deacetylation in MORC2-mediated down- regulation of carbonic anhydrase IX. (PubMed id 20110259)1, 2 Shao Y.... Li F. (Nucleic Acids Res. 2010)
    2. Identification and expression analysis of a novel CW-type zinc finger protein MORC2 in cancer cells. (PubMed id 20225202)1, 2 Wang G.L.... Li F. (Anat. Rec. 2010)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    6. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PubMed id 14607086)1, 3 Perry J. and Zhao Y. (Trends Biochem. Sci. 2003)
    7. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    8. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    9. Cytosolic functions of MORC2 in lipogenesis and adipogenesis. (PubMed id 24286864)1 SA!nchez-Solana B....Kumar R. (Biochim. Biophys. Acta 2014)
    10. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22880 HGNC: 23573 AceView: ZCWCC1 Ensembl:ENSG00000133422 euGenes: HUgn22880
    ECgene: MORC2 H-InvDB: MORC2

    (According to HUGE)
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    HUGE: KIAA0852

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MORC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MORC2 gene:
    Search GeneIP for patents involving MORC2

    GeneCards and IP:
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