Aliases for MORC2 Gene
External Ids for MORC2 Gene
Previous HGNC Symbols for MORC2 Gene
Previous GeneCards Identifiers for MORC2 Gene
This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
GeneCards Summary for MORC2 Gene
MORC2 (MORC Family CW-Type Zinc Finger 2) is a Protein Coding gene. Diseases associated with MORC2 include Charcot-Marie-Tooth Disease 2Z and Autosomal Dominant Charcot-Marie-Tooth Disease Type 2Z. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is MORC1.
UniProtKB/Swiss-Prot for MORC2 Gene
Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). May act as a transcriptional repressor (PubMed:20225202). Down-regulates CA9 expression (PubMed:20110259).