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Aliases for MORC2 Gene

Aliases for MORC2 Gene

  • MORC Family CW-Type Zinc Finger 2 2 3 5
  • Zinc Finger CW-Type Coiled-Coil Domain Protein 1 3 4
  • ZCWCC1 3 4
  • Zinc Finger, CW-Type With Coiled-Coil Domain 1 2
  • Zinc Finger, CW Type With Coiled-Coil Domain 1 2
  • KIAA0852 4
  • CMT2Z 3
  • ZCW3 3

External Ids for MORC2 Gene

Previous HGNC Symbols for MORC2 Gene

  • ZCWCC1

Previous GeneCards Identifiers for MORC2 Gene

  • GC22M029651
  • GC22M031322
  • GC22M014286

Summaries for MORC2 Gene

Entrez Gene Summary for MORC2 Gene

  • This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

GeneCards Summary for MORC2 Gene

MORC2 (MORC Family CW-Type Zinc Finger 2) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is MORC3.

UniProtKB/Swiss-Prot for MORC2 Gene

  • Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). May act as a transcriptional repressor (PubMed:20225202). Down-regulates CA9 expression (PubMed:20110259).

Gene Wiki entry for MORC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORC2 Gene

Genomics for MORC2 Gene

Regulatory Elements for MORC2 Gene

Genomic Location for MORC2 Gene

Chromosome:
22
Start:
30,925,130 bp from pter
End:
30,968,497 bp from pter
Size:
43,368 bases
Orientation:
Minus strand

Genomic View for MORC2 Gene

Genes around MORC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORC2 Gene

Proteins for MORC2 Gene

  • Protein details for MORC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6X9-MORC2_HUMAN
    Recommended name:
    MORC family CW-type zinc finger protein 2
    Protein Accession:
    Q9Y6X9
    Secondary Accessions:
    • B2RNB1
    • Q9UF28
    • Q9Y6V2

    Protein attributes for MORC2 Gene

    Size:
    1032 amino acids
    Molecular mass:
    117823 Da
    Quaternary structure:
    • Interacts with HDAC4 (PubMed:20110259). Interacts with ACLY (PubMed:24286864).
    SequenceCaution:
    • Sequence=AAC12954.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA74875.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for MORC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MORC2 Gene

Proteomics data for MORC2 Gene at MOPED

Post-translational modifications for MORC2 Gene

  • Ubiquitination at Lys 932
  • Modification sites at PhosphoSitePlus

Other Protein References for MORC2 Gene

No data available for DME Specific Peptides for MORC2 Gene

Domains & Families for MORC2 Gene

Gene Families for MORC2 Gene

Protein Domains for MORC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MORC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6X9

UniProtKB/Swiss-Prot:

MORC2_HUMAN :
  • Contains 1 CW-type zinc finger.
Similarity:
  • Contains 1 CW-type zinc finger.
genes like me logo Genes that share domains with MORC2: view

Function for MORC2 Gene

Molecular function for MORC2 Gene

UniProtKB/Swiss-Prot Function:
Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). May act as a transcriptional repressor (PubMed:20225202). Down-regulates CA9 expression (PubMed:20110259).

Phenotypes for MORC2 Gene

genes like me logo Genes that share phenotypes with MORC2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MORC2 Gene

Localization for MORC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MORC2 Gene

Nucleus. Cytoplasm, cytosol. Note=Mainly located in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MORC2 Gene COMPARTMENTS Subcellular localization image for MORC2 gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MORC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MORC2: view

Pathways & Interactions for MORC2 Gene

SuperPathways for MORC2 Gene

No Data Available

Interacting Proteins for MORC2 Gene

Gene Ontology (GO) - Biological Process for MORC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MORC2 Gene

Drugs & Compounds for MORC2 Gene

No Compound Related Data Available

Transcripts for MORC2 Gene

Unigene Clusters for MORC2 Gene

MORC family CW-type zinc finger 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MORC2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1:
SP2: - -
SP3:

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27a · 27b
SP1:
SP2:
SP3: -

Relevant External Links for MORC2 Gene

GeneLoc Exon Structure for
MORC2
ECgene alternative splicing isoforms for
MORC2

Expression for MORC2 Gene

mRNA expression in normal human tissues for MORC2 Gene

Protein differential expression in normal tissues from HIPED for MORC2 Gene

This gene is overexpressed in Kidney (21.0), Liver (13.3), and Adrenal (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MORC2 Gene



SOURCE GeneReport for Unigene cluster for MORC2 Gene Hs.555918

mRNA Expression by UniProt/SwissProt for MORC2 Gene

Q9Y6X9-MORC2_HUMAN
Tissue specificity: Highly expressed in smooth muscle, pancreas and testis.
genes like me logo Genes that share expression patterns with MORC2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for MORC2 Gene

Orthologs for MORC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MORC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MORC2 35
  • 99.51 (n)
  • 99.79 (a)
MORC2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MORC2 36
  • 87 (a)
OneToOne
MORC2 35
  • 89.31 (n)
  • 92.47 (a)
dog
(Canis familiaris)
Mammalia MORC2 35
  • 90.96 (n)
  • 94.23 (a)
MORC2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Morc2a 35
  • 86.64 (n)
  • 90.5 (a)
Morc2a 16
Morc2a 36
  • 85 (a)
OneToMany
Morc2b 36
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MORC2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MORC2 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Morc2 35
  • 86.76 (n)
  • 91.33 (a)
chicken
(Gallus gallus)
Aves MORC2 35
  • 74.28 (n)
  • 78.51 (a)
MORC2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia morc2 35
  • 66.55 (n)
  • 72.98 (a)
Str.10569 35
zebrafish
(Danio rerio)
Actinopterygii morc2 36
  • 58 (a)
OneToOne
morc2 35
  • 63.48 (n)
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea morc-1 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
OneToOne
Species with no ortholog for MORC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MORC2 Gene

ENSEMBL:
Gene Tree for MORC2 (if available)
TreeFam:
Gene Tree for MORC2 (if available)

Paralogs for MORC2 Gene

Paralogs for MORC2 Gene

(1) SIMAP similar genes for MORC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MORC2: view

Variants for MORC2 Gene

Sequence variations from dbSNP and Humsavar for MORC2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2285918 -- 30,959,368(+) TGGAG(A/C/G)GAAAG intron-variant
rs2285919 -- 30,959,649(+) AAAAA(A/C)CACTT intron-variant
rs2285920 -- 30,961,205(+) TGTGC(A/C/T)CCCTC intron-variant
rs2285921 -- 30,961,285(+) TTAAA(G/T)TACCA intron-variant
rs737927 -- 30,942,483(+) GGAGA(C/T)GTTGG intron-variant

Variation tolerance for MORC2 Gene

Residual Variation Intolerance Score: 2.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MORC2 Gene

HapMap Linkage Disequilibrium report
MORC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MORC2 Gene

Disorders for MORC2 Gene

Relevant External Links for MORC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MORC2

No disorders were found for MORC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MORC2 Gene

Publications for MORC2 Gene

  1. Cytosolic functions of MORC2 in lipogenesis and adipogenesis. (PMID: 24286864) SA!nchez-Solana B. … Kumar R. (Biochim. Biophys. Acta 2014) 3 4 67
  2. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PMID: 14607086) Perry J. … Zhao Y. (Trends Biochem. Sci. 2003) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for MORC2 Gene

Sources for MORC2 Gene

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