MORC2 Gene
protein-coding GIFtS: 48
GCID: GC22M031322
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MORC family CW-type zinc finger 2(Previous names: zinc finger, CW-type with coiled-coil domain 1, zinc finger,...)
(Previous symbol: ZCWCC1)
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Aliases
for MORC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MORC Family CW-Type Zinc Finger 21 2 | | KIAA08521 3 | | ZCWCC11 2 3 | | Zinc Finger CW-Type Coiled-Coil Domain Protein 12 3 | | ZCW31 2 | | AC004542.C22.11 | | Zinc Finger, CW Type With Coiled-Coil Domain 11 2 | | MORC Family CW-Type Zinc Finger Protein 22 | | Zinc Finger, CW-Type With Coiled-Coil Domain 11 2 | | |
Export aliases for MORC2 gene to outside databasesPrevious GC identifers: GC22M029651 GC22M014286 |
Summaries
for MORC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MORC2_HUMAN, Q9Y6X9Function: May act as a transcriptional repressor. Down-regulates CA9 expression
Gene Wiki entry for MORC2
|
Genomic Views
for MORC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MORC2 gene promoter:
NF-1/L NF-1 CP2 Pax-2 RelA Pax-2a Nkx2-5 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MORC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MORC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.2MORC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M031322: view genomic region
(about GC identifiers)
Start:
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31,322,596 bp from pter |
End:
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31,364,284 bp from pter |
Size:
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41,689 bases |
Orientation:
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minus strand |
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Proteins
for MORC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MORC2_HUMAN, Q9Y6X9 (See
protein sequence)Recommended Name: MORC family CW-type zinc finger protein 2 Size: 1032 amino acids; 117823 Da
Subunit: Interacts with HDAC4
Subcellular location: Nucleus. Cytoplasm, cytosol. Note=Mainly located in the nucleus
Sequence caution: Sequence=AAC12954.1; Type=Erroneous gene model prediction; Sequence=BAA74875.2; Type=Miscellaneousdiscrepancy; Note=Intron retention;
Secondary accessions: B2RNB1 Q9UF28 Q9Y6V2Alternative splicing: 2 isoforms: Q9Y6X9-1 Q9Y6X9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MORC2: NX_Q9Y6X9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y6X9
MORC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055756.1
ENSEMBL proteins: ENSP00000380763 ENSP00000412685 ENSP00000402602 ENSP00000215862
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MORC2 for ontologies About GeneDecksing
MORC2 Antibody Products:
Assay Products for MORC2: |
Protein
Domains /
Families
for MORC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MORC2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y6X9ProtoNet protein and cluster: Q9Y6X9 1 Blocks protein family: IPB011124 CW-type Zn-finger
UniProtKB/Swiss-Prot: MORC2_HUMAN, Q9Y6X9Similarity: Contains 1 CW-type zinc finger |
Function
for MORC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MORC2_HUMAN, Q9Y6X9Function: May act as a transcriptional repressor. Down-regulates CA9 expression
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MORC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MORC2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MORC2 (NM_014941) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MORC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORC2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
MORC2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MORC2:
|
Pathways & Interactions
for MORC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MORC2
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for MORC2 (Q9Y6X93 ENSP000002158624) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for MORC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MORC2
Search CenterWatch for drugs/clinical trials and news about MORC2
|
Transcripts
for MORC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MORC2 gene: NM_014941.1 Unigene Cluster for MORC2: MORC family CW-type zinc finger 2 Hs.555918 [show with all ESTs]Unigene Representative Sequence: AB0206596 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397641 ENST00000429468 ENST00000445980 ENST00000215862(uc003aje.1)
ENST00000469915 ENST00000476152
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MORC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MORC2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MORC2 (NM_014941) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MORC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORC2 |
Additional cDNA sequence: AB020659.1 AL133637.1 AY236964.1 BC019257.1 BC136782.1 CR456469.1 9 DOTS entries: DT.100745725 DT.445979 DT.100027705 DT.100745726 DT.100687928 DT.100745727 DT.100643282 DT.100694589 DT.75101604 24/150 AceView cDNA sequences (see all 150): BM989325 BQ723446 AW028931 AW290945 BC019257 AA846534 BM846374 AI476582 BM709826 AA782720 BU688082 AA300204 AI357355 AI281226 BM973339 BU838928 BM989149 AW276421 AA480159 AW243857 CD251926 BU149482 CA428814 BM667006
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for MORC2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27a | · | 27b |
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for MORC2
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Expression
for MORC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MORC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTTGGTGGT
About this image
See MORC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MORC2
SOURCE GeneReport for Unigene cluster: Hs.555918
UniProtKB/Swiss-Prot: MORC2_HUMAN, Q9Y6X9Tissue specificity: Highly expressed in smooth muscle, pancreas and testis
SABiosciences Custom PCR Arrays for MORC2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MORC2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MORC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MORC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORC2 |
Orthologs
for MORC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MORC2 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for MORC2 (if available)
TreeFam Gene Tree for MORC2 (if available) |
Paralogs
for MORC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MORC2 gene
- MORC32 MORC42 MORC12
1 SIMAP similar gene for MORC2 using alignment to 3 protein entries: MORC2_HUMAN (see all proteins):MORC1
MORC2 for paralogs About GeneDecksing
|
Genomic Variants
for MORC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MORC2 (31322596 - 31364284 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MORC2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MORC2 |
|
Disorders
/ Diseases
for MORC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for MORC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MORC2 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with MORC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Involvement of histone deacetylation in MORC2-mediate d down-regulation of carbonic anhydrase IX. (PubMed id 20110259)1, 2 Shao Y....Li F. (2010)
- Identification and expression analysis of a novel CW- type zinc finger protein MORC2 in cancer cells. (PubMed id 20225202)1, 2 Wang G.L....Li F. (2010)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. (PubMed id 14607086)1, 3 Perry J. and Zhao Y. (2003)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for MORC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MORC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MORC2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing MORC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MORC2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MORC2 gene:
Search GeneIP for patents involving MORC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MORC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MORC2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MORC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MORC2 | | | OriGene Protein Over-expression Lysate for MORC2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MORC2 | | OriGene 3'-UTR Clone for MORC2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MORC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MORC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MORC2 | | OriGene Custom Protein Services for MORC2 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MORC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MORC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MORC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MORC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MORC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MORC2 |
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| | | | Search Tocris compounds for MORC2 |
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 | | | MORC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MORC2 |
|  |  |  | | | | ThermoFisher Antibodies for MORC2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MORC2 |
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