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Aliases for MORC1 Gene

Aliases for MORC1 Gene

  • MORC Family CW-Type Zinc Finger 1 2 3
  • Cancer/Testis Antigen 33 2 3 4
  • MORC 3 4
  • CT33 3 4
  • MORC Family CW-Type Zinc Finger Protein 1 3
  • Microrchidia, Mouse, Homolog Of 3
  • Microrchidia (Mouse) Homolog 2
  • Microrchidia Homolog (Mouse) 2
  • ZCW6 3

External Ids for MORC1 Gene

Previous HGNC Symbols for MORC1 Gene

  • MORC

Previous GeneCards Identifiers for MORC1 Gene

  • GC03M110160
  • GC03M108677
  • GC03M106050

Summaries for MORC1 Gene

Entrez Gene Summary for MORC1 Gene

  • This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]

GeneCards Summary for MORC1 Gene

MORC1 (MORC Family CW-Type Zinc Finger 1) is a Protein Coding gene. An important paralog of this gene is MORC2.

UniProtKB/Swiss-Prot for MORC1 Gene

  • Required for spermatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORC1 Gene

Genomics for MORC1 Gene

Regulatory Elements for MORC1 Gene

Genomic Location for MORC1 Gene

Start:
108,957,967 bp from pter
End:
109,118,146 bp from pter
Size:
160,180 bases
Orientation:
Minus strand

Genomic View for MORC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MORC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORC1 Gene

Proteins for MORC1 Gene

  • Protein details for MORC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VD1-MORC1_HUMAN
    Recommended name:
    MORC family CW-type zinc finger protein 1
    Protein Accession:
    Q86VD1
    Secondary Accessions:
    • B4DYX1
    • E7ERX1
    • Q7L8E2
    • Q9NSG7
    • Q9Y6D4

    Protein attributes for MORC1 Gene

    Size:
    984 amino acids
    Molecular mass:
    112881 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MORC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MORC1 Gene

Proteomics data for MORC1 Gene at MOPED

Post-translational modifications for MORC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MORC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MORC1 Gene

Domains for MORC1 Gene

Protein Domains for MORC1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MORC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VD1

UniProtKB/Swiss-Prot:

MORC1_HUMAN :
  • Q86VD1
Similarity:
  • Contains 1 CW-type zinc finger.
genes like me logo Genes that share domains with MORC1: view

No data available for Gene Families for MORC1 Gene

Function for MORC1 Gene

Molecular function for MORC1 Gene

UniProtKB/Swiss-Prot Function: Required for spermatogenesis.

Gene Ontology (GO) - Molecular Function for MORC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MORC1: view

Phenotypes for MORC1 Gene

genes like me logo Genes that share phenotypes with MORC1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MORC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MORC1 Gene

Localization for MORC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MORC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MORC1 Gene COMPARTMENTS Subcellular localization image for MORC1 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MORC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MORC1: view

Pathways for MORC1 Gene

SuperPathways for MORC1 Gene

No Data Available

Interacting Proteins for MORC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000232603%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000232603 for MORC1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for MORC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MORC1: view

No data available for Pathways by source for MORC1 Gene

Transcripts for MORC1 Gene

mRNA/cDNA for MORC1 Gene

(13) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(9) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MORC1 Gene

MORC family CW-type zinc finger 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MORC1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MORC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MORC1 Gene

No ASD Table

Relevant External Links for MORC1 Gene

GeneLoc Exon Structure for
MORC1
ECgene alternative splicing isoforms for
MORC1

Expression for MORC1 Gene

mRNA expression in normal human tissues for MORC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MORC1 Gene

This gene is overexpressed in Testis (41.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MORC1 Gene

SOURCE GeneReport for Unigene cluster for MORC1 Gene Hs.591296

genes like me logo Genes that share expressions with MORC1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MORC1 Gene

Orthologs for MORC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MORC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MORC1 35
  • 99.19 (n)
  • 98.48 (a)
MORC1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MORC1 35
  • 84.58 (n)
  • 78.37 (a)
MORC1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MORC1 35
  • 83.02 (n)
  • 75.77 (a)
MORC1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Morc1 35
  • 77.36 (n)
  • 68.89 (a)
Morc1 16
Morc1 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MORC1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 27 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Morc1 35
  • 77.8 (n)
  • 69.79 (a)
lizard
(Anolis carolinensis)
Reptilia MORC1 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea morc-1 36
  • 22 (a)
OneToMany
Species with no ortholog for MORC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MORC1 Gene

ENSEMBL:
Gene Tree for MORC1 (if available)
TreeFam:
Gene Tree for MORC1 (if available)

Paralogs for MORC1 Gene

Paralogs for MORC1 Gene

Selected SIMAP similar genes for MORC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MORC1: view

Variants for MORC1 Gene

Sequence variations from dbSNP and Humsavar for MORC1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs895738 -- 109,063,313(+) CTATA(C/T)GCTCC intron-variant
rs921172 -- 109,051,543(+) AATAT(A/G)TGAAT intron-variant
rs921173 -- 108,974,963(+) CTCTA(C/T)AAATT intron-variant
rs921174 -- 108,975,004(+) GGCCA(C/T)TTCCA intron-variant
rs982253 -- 109,050,341(+) CCGAG(A/T)TCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MORC1 Gene

Variant ID Type Subtype PubMed ID
nsv522119 CNV Gain 19592680
nsv829662 CNV Gain 17160897
nsv829663 CNV Gain 17160897
nsv877327 CNV Loss 21882294
nsv829664 CNV Gain 17160897
nsv3938 CNV Loss 18451855
nsv877328 CNV Loss 21882294
esv6452 CNV Gain 19470904
esv2665202 CNV Deletion 23128226
esv2669479 CNV Deletion 23128226
nsv522072 CNV Loss 19592680
nsv518111 CNV Loss 19592680
nsv819011 CNV Gain 19587683

Relevant External Links for MORC1 Gene

HapMap Linkage Disequilibrium report
MORC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MORC1 Gene

Disorders for MORC1 Gene

Relevant External Links for MORC1

Genetic Association Database (GAD)
MORC1
Human Genome Epidemiology (HuGE) Navigator
MORC1
genes like me logo Genes that share disorders with MORC1: view

No data available for UniProtKB/Swiss-Prot for MORC1 Gene

Publications for MORC1 Gene

  1. New gene family defined by MORC, a nuclear protein required for mouse spermatogenesis. (PMID: 10369865) Inoue N. … Zinn A.R. (Hum. Mol. Genet. 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits. (PMID: 24204828) Zheng J.S. … Lai C.Q. (PLoS ONE 2013) 3

Products for MORC1 Gene

Sources for MORC1 Gene

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