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MORC1 Gene

protein-coding   GIFtS: 49
GCID: GC03M108677

MORC Family CW-Type Zinc Finger 1

(Previous names: microrchidia (mouse) homolog, microrchidia homolog (mouse))
(Previous symbol: MORC)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MORC Family CW-Type Zinc Finger 11 2     Microrchidia Homolog (Mouse)1
MORC1 2 3     ZCW62
Cancer/Testis Antigen 331 2 3     Microrchidia, Mouse, Homolog Of2
CT332 3     MORC Family CW-Type Zinc Finger Protein 12
Microrchidia (Mouse) Homolog1     

External Ids:    HGNC: 71981   Entrez Gene: 271362   Ensembl: ENSG000001144877   OMIM: 6032055   UniProtKB: Q86VD13   

Export aliases for MORC1 gene to outside databases

Previous GC identifers: GC03M110160 GC03M106050


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MORC1 Gene:
This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies
support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent
defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting
entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells.
(provided by RefSeq, Jan 2009)

GeneCards Summary for MORC1 Gene:
MORC1 (MORC family CW-type zinc finger 1) is a protein-coding gene. An important paralog of this gene is MORC2.

UniProtKB/Swiss-Prot: MORC1_HUMAN, Q86VD1
Function: Required for spermatogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MORC1 gene promoter:
         AML1a   MEF-2   CUTL1   POU6F1 (c2)   LUN-1   MEF-2A   S8   FOXJ2 (long isoform)   FOXJ2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMORC1 promoter sequence
   Search Chromatin IP Primers for MORC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MORC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13   Ensembl cytogenetic band:  3q13.13   HGNC cytogenetic band: 3q13

MORC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MORC1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M108677:  view genomic region     (about GC identifiers)

Start:
108,677,086 bp from pter      End:
108,836,993 bp from pter
Size:
159,908 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MORC1_HUMAN, Q86VD1 (See protein sequence)
Recommended Name: MORC family CW-type zinc finger protein 1  
Size: 984 amino acids; 112881 Da
Secondary accessions: Q7L8E2 Q9NSG7 Q9Y6D4

Explore the universe of human proteins at neXtProt for MORC1: NX_Q86VD1

Explore proteomics data for MORC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MORC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055244.3  
    ENSEMBL proteins: 
     ENSP00000232603   ENSP00000417282  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003594 HATPase_ATP-bd
     IPR011124 Znf_CW

    Graphical View of Domain Structure for InterPro Entry Q86VD1

    ProtoNet protein and cluster: Q86VD1

    1 Blocks protein domain: IPB011124 CW-type Zn-finger

    UniProtKB/Swiss-Prot: MORC1_HUMAN, Q86VD1
    Similarity: Contains 1 CW-type zinc finger


    Find genes that share domains with MORC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MORC1_HUMAN, Q86VD1
    Function: Required for spermatogenesis (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with MORC1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MORC1:
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MORC1
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    SwitchGear 3'UTR luciferase reporter plasmidMORC1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MORC1_HUMAN, Q86VD1: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with MORC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MORC1
    Interactions:

        Search GeneGlobe Interaction Network for MORC1

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with MORC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MORC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MORC1 gene: 
    NM_014429.3  

    Unigene Cluster for MORC1:

    MORC family CW-type zinc finger 1
    Hs.591296  [show with all ESTs]
    Unigene Representative Sequence: NM_014429
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000232603(uc003dxl.3 uc011bhn.2) ENST00000483760
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate MORC1:
    hsa-miR-33a* hsa-miR-4307 hsa-miR-576-5p hsa-miR-186 hsa-miR-4263
    SwitchGear 3'UTR luciferase reporter plasmidMORC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MORC1
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      QuantiFast Probe-based Assays in human, mouse, rat MORC1

    Additional mRNA sequence: 

    AF084946.1 AK302642.1 AL353955.1 BC028680.1 BC050307.1 

    1 DOTS entry:

    DT.91756133 

    13 AceView cDNA sequences:

    BC050307 CD557956 BC028680 NM_014429 BG772896 BG202992 BG195280 AL353955 
    BG183322 BG718629 AF084946 BG186982 BG206664 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MORC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGCTACTG
    MORC1 Expression
    About this image


    MORC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gonad
             Primordial Germ Cells Allantois
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Placenta (Extraembryonic Tissues)
             Primordial Germ Cells Allantois
    MORC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MORC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591296
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MORC1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Morc11 , 5 microrchidia 11, 5 77.36(n)1
    68.89(a)1
      16 (30.75 cM)5
    174501  NM_010816.11  NP_034946.11 
     484312375 
    lizard
    (Anolis carolinensis)
    Reptilia MORC16
    MORC family CW-type zinc finger 1
    43(a)
    1 ↔ 1
    3(168862538-168950135)
    worm
    (Caenorhabditis elegans)
    Secernentea morc-16
    Protein MORC-1 (morc-1) mRNA, complete cds
    22(a)
    1 → many
    III(5203689-5206911) WBGene00022531


    ENSEMBL Gene Tree for MORC1 (if available)
    TreeFam Gene Tree for MORC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MORC1 gene
    MORC22  MORC32  MORC42  
    1 SIMAP similar gene for MORC1 using alignment to 2 protein entries:     MORC1_HUMAN (see all proteins):
    MORC2

    Find genes that share paralogs with MORC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MORC1 (see all 3292)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs27157361,2
    C,F,Auntested1108697020(-) TTGGCA/C/TGGGCG 1 -- int16NA CSA WA 128
    rs717154541,2
    C--106095813(+) GTATG-/CACA  
            
    CACAC
    1 -- int10--------
    rs284312181,2
    C,F--108676743(+) TAATAA/CGGAGC 1 -- ds50014Minor allele frequency- C:0.14NA WA 242
    rs1850137231,2
    --108676862(+) CAACAG/TCAGCA 1 -- ds50010--------
    rs749826811,2
    C--108676917(+) ATATAC/TGGTTT 1 -- ds50010--------
    rs1142099261,2
    F--108676931(+) AGATAT/CTGATT 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs25939311,2
    C,F,A,H--108676951(+) TTTACG/AAGGAA 1 -- ds500117Minor allele frequency- A:0.14NS EA NA CSA WA 2090
    rs1895401741,2
    --108677073(+) TAAATC/TAAAAT 1 -- ds50010--------
    rs27157611,2
    C,F,A--108677113(-) AAACAG/ATAAAA 1 -- ut3110Minor allele frequency- A:0.31NA CSA WA EA 507
    rs732006441,2
    C,F--108677195(+) TTACGT/CATATG 1 -- ut311Minor allele frequency- C:0.05NA 120

    HapMap Linkage Disequilibrium report for MORC1 (108677086 - 108836993 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MORC1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665202CNV Deletion23128226
    esv2669479CNV Deletion23128226
    nsv522072CNV Loss19592680
    nsv518111CNV Loss19592680
    nsv3938CNV Loss18451855
    nsv877327CNV Loss21882294
    nsv877328CNV Loss21882294
    esv6452CNV Gain19470904
    nsv829662CNV Gain17160897
    nsv829663CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MORC1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603205    OMIM disorders: --


    Find genes that share disorders with MORC1           About GenesLikeMe

    Genetic Association Database (GAD): MORC1
    Human Genome Epidemiology (HuGE) Navigator: MORC1 (1 document)

    Export disorders for MORC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MORC1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MORC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. New gene family defined by MORC, a nuclear protein required for mouse spermatogenesis. (PubMed id 10369865)1, 2, 3 Inoue N.... Zinn A.R. (Hum. Mol. Genet. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Assignment of microrchidia (Morc) to mouse chromosome 16 by interspecific backcross linkage analysis and human chromosome 3q13 using somatic cell hybrids and in situ hybridization. (PubMed id 11060461)1 Inoue N....Watson M.L. (Cytogenet. Cell Genet. 2000)
    9. Involvement of histone deacetylation in MORC2-mediated down- regulation of carbonic anhydrase IX. (PubMed id 20110259)9 Shao Y.... Li F. (Nucleic Acids Res. 2010)
    10. Identification and expression analysis of a novel CW-type zinc finger protein MORC2 in cancer cells. (PubMed id 20225202)9 Wang G.L.... Li F. (Anat. Rec. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27136 HGNC: 7198 AceView: MORC Ensembl:ENSG00000114487 euGenes: HUgn27136
    ECgene: MORC1 H-InvDB: MORC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MORC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MORC1 gene:
    Search GeneIP for patents involving MORC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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