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Aliases for MORC1 Gene

Aliases for MORC1 Gene

  • MORC Family CW-Type Zinc Finger 1 2 3 5
  • Cancer/Testis Antigen 33 2 3 4
  • MORC 3 4
  • CT33 3 4
  • MORC Family CW-Type Zinc Finger Protein 1 3
  • Microrchidia, Mouse, Homolog Of 3
  • Microrchidia (Mouse) Homolog 2
  • Microrchidia Homolog (Mouse) 2
  • ZCW6 3

External Ids for MORC1 Gene

Previous HGNC Symbols for MORC1 Gene

  • MORC

Previous GeneCards Identifiers for MORC1 Gene

  • GC03M110160
  • GC03M108677
  • GC03M106050

Summaries for MORC1 Gene

Entrez Gene Summary for MORC1 Gene

  • This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]

GeneCards Summary for MORC1 Gene

MORC1 (MORC Family CW-Type Zinc Finger 1) is a Protein Coding gene. Diseases associated with MORC1 include Suppurative Thyroiditis. An important paralog of this gene is MORC2.

UniProtKB/Swiss-Prot for MORC1 Gene

  • Required for spermatogenesis.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MORC1 Gene

Genomics for MORC1 Gene

Regulatory Elements for MORC1 Gene

Enhancers for MORC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G109071 0.8 Ensembl dbSUPER 22 +46.0 46046 1.0 MEF2D CTCF PKNOX1 RAD21 EP300 MORC1 MORC1-AS1 ENSG00000221633 GC03M109019
GH03G109082 1.1 Ensembl ENCODE 10.5 +36.0 36046 0.2 CTCF PKNOX1 ZNF384 EBF1 RAD21 RELA CBX5 ELK1 EED ZNF143 MORC1 MORC1-AS1 ENSG00000221633 GC03M109019
GH03G109059 0.7 Ensembl 11.6 +58.8 58846 0.2 MTA2 BACH1 JUNB BMI1 DPF2 EP300 TBX21 JUND CBX5 IKZF1 MORC1 GC03M109019 ENSG00000221633 MORC1-AS1
GH03G109132 0.7 ENCODE 10.7 -15.4 -15369 1.9 SP3 TAF1 MAX RAD21 YY1 FOXA1 JUND ATF3 HNF4G HNF4A MORC1-AS1 MORC1 FLJ22763 ENSG00000261364
GH03G109070 0.6 Ensembl dbSUPER 10.4 +47.6 47646 0.6 NFE2 ENSG00000221633 MORC1-AS1 MORC1 GC03M109019
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MORC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MORC1 Gene

Chromosome:
3
Start:
108,958,239 bp from pter
End:
109,118,146 bp from pter
Size:
159,908 bases
Orientation:
Minus strand

Genomic View for MORC1 Gene

Genes around MORC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MORC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MORC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MORC1 Gene

Proteins for MORC1 Gene

  • Protein details for MORC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VD1-MORC1_HUMAN
    Recommended name:
    MORC family CW-type zinc finger protein 1
    Protein Accession:
    Q86VD1
    Secondary Accessions:
    • B4DYX1
    • E7ERX1
    • Q7L8E2
    • Q9NSG7
    • Q9Y6D4

    Protein attributes for MORC1 Gene

    Size:
    984 amino acids
    Molecular mass:
    112881 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MORC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MORC1 Gene

Post-translational modifications for MORC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MORC1 Gene

Domains & Families for MORC1 Gene

Gene Families for MORC1 Gene

Protein Domains for MORC1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MORC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MORC1: view

No data available for UniProtKB/Swiss-Prot for MORC1 Gene

Function for MORC1 Gene

Molecular function for MORC1 Gene

UniProtKB/Swiss-Prot Function:
Required for spermatogenesis.

Gene Ontology (GO) - Molecular Function for MORC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MORC1: view
genes like me logo Genes that share phenotypes with MORC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MORC1 Gene

Localization for MORC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MORC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MORC1 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MORC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with MORC1: view

Pathways & Interactions for MORC1 Gene

SuperPathways for MORC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MORC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis TAS,IEA --
GO:0010529 negative regulation of transposition IEA --
GO:0030154 cell differentiation IEA --
GO:0040029 regulation of gene expression, epigenetic IEA --
genes like me logo Genes that share ontologies with MORC1: view

No data available for Pathways by source and SIGNOR curated interactions for MORC1 Gene

Drugs & Compounds for MORC1 Gene

No Compound Related Data Available

Transcripts for MORC1 Gene

mRNA/cDNA for MORC1 Gene

(10) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MORC1 Gene

MORC family CW-type zinc finger 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MORC1 Gene

No ASD Table

Relevant External Links for MORC1 Gene

GeneLoc Exon Structure for
MORC1
ECgene alternative splicing isoforms for
MORC1

Expression for MORC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MORC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MORC1 Gene

This gene is overexpressed in Testis (x41.6).

Protein differential expression in normal tissues from HIPED for MORC1 Gene

This gene is overexpressed in Neutrophil (34.3), Monocytes (15.2), and Plasma (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MORC1 Gene



Protein tissue co-expression partners for MORC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MORC1 Gene:

MORC1

SOURCE GeneReport for Unigene cluster for MORC1 Gene:

Hs.591296
genes like me logo Genes that share expression patterns with MORC1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MORC1 Gene

Orthologs for MORC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MORC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MORC1 34 35
  • 99.19 (n)
cow
(Bos Taurus)
Mammalia MORC1 34 35
  • 84.58 (n)
dog
(Canis familiaris)
Mammalia MORC1 34 35
  • 83.02 (n)
rat
(Rattus norvegicus)
Mammalia Morc1 34
  • 77.8 (n)
mouse
(Mus musculus)
Mammalia Morc1 34 16 35
  • 77.36 (n)
oppossum
(Monodelphis domestica)
Mammalia MORC1 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 27 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia MORC1 35
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea morc-1 35
  • 22 (a)
OneToMany
Species where no ortholog for MORC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MORC1 Gene

ENSEMBL:
Gene Tree for MORC1 (if available)
TreeFam:
Gene Tree for MORC1 (if available)

Paralogs for MORC1 Gene

Paralogs for MORC1 Gene

(1) SIMAP similar genes for MORC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MORC1: view

Variants for MORC1 Gene

Sequence variations from dbSNP and Humsavar for MORC1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000006707 -- 108,971,897(+) GCCTC(A/G)CAATC intron-variant
rs1000020163 -- 109,012,808(+) TGTAA(A/G)TATTA intron-variant
rs1000038007 -- 109,054,795(+) TACTC(C/T)TGGAC reference, synonymous-codon
rs1000055954 -- 109,011,046(+) GATAG(A/G)TATAT intron-variant
rs1000071325 -- 109,100,623(+) CTTGG(A/G)TCAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MORC1 Gene

Variant ID Type Subtype PubMed ID
dgv1400e212 CNV loss 25503493
dgv4836n100 CNV gain 25217958
esv2665202 CNV deletion 23128226
esv2669479 CNV deletion 23128226
esv3597338 CNV loss 21293372
esv3597339 CNV loss 21293372
esv3597340 CNV loss 21293372
esv3597341 CNV loss 21293372
esv6452 CNV gain 19470904
nsv3938 CNV deletion 18451855
nsv474889 CNV novel sequence insertion 20440878
nsv518111 CNV loss 19592680
nsv522072 CNV loss 19592680
nsv522119 CNV gain 19592680
nsv819011 CNV gain 19587683
nsv829662 CNV gain 17160897
nsv829663 CNV gain 17160897
nsv829664 CNV gain 17160897

Variation tolerance for MORC1 Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.60; 91.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MORC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MORC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MORC1 Gene

Disorders for MORC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MORC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
suppurative thyroiditis
  • acute suppurative thyroiditis
- elite association - COSMIC cancer census association via MalaCards
Search MORC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MORC1

Genetic Association Database (GAD)
MORC1
Human Genome Epidemiology (HuGE) Navigator
MORC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MORC1
genes like me logo Genes that share disorders with MORC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MORC1 Gene

Publications for MORC1 Gene

  1. New gene family defined by MORC, a nuclear protein required for mouse spermatogenesis. (PMID: 10369865) Inoue N. … Zinn A.R. (Hum. Mol. Genet. 1999) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Genome-wide diet-gene interaction analyses for risk of colorectal cancer. (PMID: 24743840) Figueiredo J.C. … . (PLoS Genet. 2014) 3 64

Products for MORC1 Gene

Sources for MORC1 Gene

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