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Aliases for MON2 Gene

Aliases for MON2 Gene

  • MON2 Homolog, Regulator Of Endosome-To-Golgi Trafficking 2 3
  • MON2 Homolog (S. Cerevisiae) 2
  • MON2 Homolog (Yeast) 2
  • Protein SF21 4
  • KIAA1040 4
  • SF21 4

External Ids for MON2 Gene

Previous GeneCards Identifiers for MON2 Gene

  • GC12P061147
  • GC12P062860
  • GC12P059911

Summaries for MON2 Gene

GeneCards Summary for MON2 Gene

MON2 (MON2 Homolog, Regulator Of Endosome-To-Golgi Trafficking) is a Protein Coding gene. GO annotations related to this gene include binding and ARF guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for MON2 Gene

  • May be required for traffic between late Golgi and early endosomes.

Gene Wiki entry for MON2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MON2 Gene

Genomics for MON2 Gene

Regulatory Elements for MON2 Gene

Genomic Location for MON2 Gene

Chromosome:
12
Start:
62,466,817 bp from pter
End:
62,600,479 bp from pter
Size:
133,663 bases
Orientation:
Plus strand

Genomic View for MON2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MON2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MON2 Gene

Proteins for MON2 Gene

  • Protein details for MON2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3U7-MON2_HUMAN
    Recommended name:
    Protein MON2 homolog
    Protein Accession:
    Q7Z3U7
    Secondary Accessions:
    • A5D8U7
    • A7E2Y0
    • B9EGP5
    • F8VWA6
    • F8W1Z6
    • Q86TA2
    • Q8N3I5
    • Q8NAI0
    • Q8NHE2
    • Q9UPW1

    Protein attributes for MON2 Gene

    Size:
    1717 amino acids
    Molecular mass:
    190359 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA82992.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MON2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MON2 Gene

Proteomics data for MON2 Gene at MOPED

Post-translational modifications for MON2 Gene

  • Ubiquitination at Lys 281 and Lys 288
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MON2 Gene

Domains & Families for MON2 Gene

Protein Domains for MON2 Gene

Suggested Antigen Peptide Sequences for MON2 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z3U7

UniProtKB/Swiss-Prot:

MON2_HUMAN :
  • Belongs to the MON2 family.
Family:
  • Belongs to the MON2 family.
genes like me logo Genes that share domains with MON2: view

No data available for Gene Families for MON2 Gene

Function for MON2 Gene

Molecular function for MON2 Gene

UniProtKB/Swiss-Prot Function:
May be required for traffic between late Golgi and early endosomes.

Gene Ontology (GO) - Molecular Function for MON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005086 ARF guanyl-nucleotide exchange factor activity IBA --
GO:0005488 binding --
GO:0005515 protein binding IPI 18418388
genes like me logo Genes that share ontologies with MON2: view

Phenotypes for MON2 Gene

GenomeRNAi human phenotypes for MON2:
genes like me logo Genes that share phenotypes with MON2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MON2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MON2 Gene

Localization for MON2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MON2 Gene COMPARTMENTS Subcellular localization image for MON2 gene
Compartment Confidence
extracellular 5
golgi apparatus 3
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for MON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 trans-Golgi network IBA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with MON2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MON2 Gene

Pathways & Interactions for MON2 Gene

SuperPathways for MON2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006895 Golgi to endosome transport ISS --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IBA --
GO:0043547 positive regulation of GTPase activity IBA --
genes like me logo Genes that share ontologies with MON2: view

No data available for Pathways by source and SIGNOR curated interactions for MON2 Gene

Drugs & Compounds for MON2 Gene

No Compound Related Data Available

Transcripts for MON2 Gene

Unigene Clusters for MON2 Gene

MON2 homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MON2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MON2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1: - -
SP2:
SP3:
SP4: - - - - -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 22b · 22c ^ 23a · 23b ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b
SP1:
SP2: - - -
SP3: - - - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:

Relevant External Links for MON2 Gene

GeneLoc Exon Structure for
MON2
ECgene alternative splicing isoforms for
MON2

Expression for MON2 Gene

mRNA expression in normal human tissues for MON2 Gene

Protein differential expression in normal tissues from HIPED for MON2 Gene

This gene is overexpressed in Bone (51.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MON2 Gene



SOURCE GeneReport for Unigene cluster for MON2 Gene Hs.389378

genes like me logo Genes that share expression patterns with MON2: view

Protein tissue co-expression partners for MON2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MON2 Gene

Orthologs for MON2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MON2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MON2 35
  • 93.71 (n)
  • 98.02 (a)
MON2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MON2 35
  • 94.2 (n)
  • 98.19 (a)
MON2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mon2 35
  • 85.96 (n)
  • 94.8 (a)
Mon2 16
Mon2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MON2 35
  • 99.77 (n)
  • 99.88 (a)
MON2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mon2 35
  • 87.42 (n)
  • 95.31 (a)
oppossum
(Monodelphis domestica)
Mammalia MON2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MON2 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves MON2 35
  • 83.53 (n)
  • 93.88 (a)
MON2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MON2 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mon2 35
  • 78.2 (n)
  • 89.11 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100334806 35
  • 71.34 (n)
  • 85.03 (a)
wufc16c07 35
mon2 36
  • 83 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.391 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009972 35
  • 54.94 (n)
  • 55.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta mon2 35
  • 54.82 (n)
  • 51.31 (a)
mon2 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mon-2 35
  • 48.28 (n)
  • 35.82 (a)
mon-2 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MON2 36
  • 20 (a)
OneToOne
Species with no ortholog for MON2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MON2 Gene

ENSEMBL:
Gene Tree for MON2 (if available)
TreeFam:
Gene Tree for MON2 (if available)

Paralogs for MON2 Gene

No data available for Paralogs for MON2 Gene

Variants for MON2 Gene

Sequence variations from dbSNP and Humsavar for MON2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs12357 -- 62,592,840(+) CTGCA(A/G)ATAAT utr-variant-3-prime, nc-transcript-variant
rs12510 -- 62,592,922(-) TTTGT(A/T)GATGT utr-variant-3-prime, nc-transcript-variant
rs732372 -- 62,542,974(+) TATAA(C/T)TTTAT intron-variant
rs774534 -- 62,590,299(-) cctgg(C/G)caaca intron-variant
rs810180 -- 62,584,869(-) aactt(C/T)tttcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MON2 Gene

Variant ID Type Subtype PubMed ID
dgv1433n71 CNV Loss 21882294
nsv821671 CNV Loss 15273396
nsv739 CNV Insertion 18451855
esv268651 CNV Insertion 20981092
esv274602 CNV Insertion 20981092
nsv469418 CNV Loss 19166990
esv2745966 CNV Deletion 23290073
esv2658375 CNV Deletion 23128226
nsv740 CNV Insertion 18451855

Variation tolerance for MON2 Gene

Residual Variation Intolerance Score: 5.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.08; 98.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MON2 Gene

HapMap Linkage Disequilibrium report
MON2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MON2 Gene

Disorders for MON2 Gene

Relevant External Links for MON2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MON2
genes like me logo Genes that share disorders with MON2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MON2 Gene

Publications for MON2 Gene

  1. Mammalian Mon2/Ysl2 regulates endosome-to-Golgi trafficking but possesses no guanine nucleotide exchange activity toward Arl1 GTPase. (PMID: 24285343) Mahajan D. … Lu L. (Sci Rep 2013) 2 67
  2. Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus. (PMID: 16301316) Gillingham A.K. … Munro S. (J. Biol. Chem. 2006) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for MON2 Gene

Sources for MON2 Gene

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