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Aliases for MON2 Gene

Aliases for MON2 Gene

  • MON2 Homolog (S. Cerevisiae) 2 3
  • MON2 Homolog (Yeast) 2
  • Protein SF21 4
  • KIAA1040 4
  • SF21 4

External Ids for MON2 Gene

Previous GeneCards Identifiers for MON2 Gene

  • GC12P061147
  • GC12P062860
  • GC12P059911

Summaries for MON2 Gene

GeneCards Summary for MON2 Gene

MON2 (MON2 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include ARF guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for MON2 Gene

  • May be required for traffic between late Golgi and early endosomes.

Gene Wiki entry for MON2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MON2 Gene

Genomics for MON2 Gene

Regulatory Elements for MON2 Gene

Genomic Location for MON2 Gene

Start:
62,466,817 bp from pter
End:
62,600,479 bp from pter
Size:
133,663 bases
Orientation:
Plus strand

Genomic View for MON2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MON2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MON2 Gene

Proteins for MON2 Gene

  • Protein details for MON2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3U7-MON2_HUMAN
    Recommended name:
    Protein MON2 homolog
    Protein Accession:
    Q7Z3U7
    Secondary Accessions:
    • A5D8U7
    • A7E2Y0
    • B9EGP5
    • F8VWA6
    • F8W1Z6
    • Q86TA2
    • Q8N3I5
    • Q8NAI0
    • Q8NHE2
    • Q9UPW1

    Protein attributes for MON2 Gene

    Size:
    1717 amino acids
    Molecular mass:
    190359 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA82992.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MON2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MON2 Gene

Proteomics data for MON2 Gene at MOPED

Post-translational modifications for MON2 Gene

  • Ubiquitination at Lys281 and Lys288
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MON2 Gene

Domains for MON2 Gene

Protein Domains for MON2 Gene

Suggested Antigen Peptide Sequences for MON2 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z3U7

UniProtKB/Swiss-Prot:

MON2_HUMAN :
  • Q7Z3U7
Family:
  • Belongs to the MON2 family.
genes like me logo Genes that share domains with MON2: view

No data available for Gene Families for MON2 Gene

Function for MON2 Gene

Molecular function for MON2 Gene

UniProtKB/Swiss-Prot Function: May be required for traffic between late Golgi and early endosomes.

Gene Ontology (GO) - Molecular Function for MON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005086 ARF guanyl-nucleotide exchange factor activity IBA --
GO:0005488 binding --
GO:0005515 protein binding IPI 18418388
genes like me logo Genes that share ontologies with MON2: view

Animal Model Products

CRISPR Products

miRNA for MON2 Gene

miRTarBase miRNAs that target MON2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MON2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MON2 Gene

Localization for MON2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MON2 Gene COMPARTMENTS Subcellular localization image for MON2 gene
Compartment Confidence
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 trans-Golgi network IBA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with MON2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MON2 Gene

Pathways for MON2 Gene

SuperPathways for MON2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006895 Golgi to endosome transport ISS --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IBA --
GO:0030036 actin cytoskeleton organization IBA --
GO:0043547 positive regulation of GTPase activity IBA --
genes like me logo Genes that share ontologies with MON2: view

No data available for Pathways by source for MON2 Gene

Transcripts for MON2 Gene

Unigene Clusters for MON2 Gene

MON2 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MON2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MON2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MON2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1: - -
SP2:
SP3:
SP4: - - - - -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 22b · 22c ^ 23a · 23b ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b
SP1:
SP2: - - -
SP3: - - - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:

Relevant External Links for MON2 Gene

GeneLoc Exon Structure for
MON2
ECgene alternative splicing isoforms for
MON2

Expression for MON2 Gene

mRNA expression in normal human tissues for MON2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MON2 Gene

SOURCE GeneReport for Unigene cluster for MON2 Gene Hs.389378

genes like me logo Genes that share expressions with MON2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MON2 Gene

Orthologs for MON2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MON2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MON2 35
  • 99.77 (n)
  • 99.88 (a)
MON2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MON2 35
  • 93.71 (n)
  • 98.02 (a)
MON2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MON2 35
  • 94.2 (n)
  • 98.19 (a)
MON2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mon2 35
  • 85.96 (n)
  • 94.8 (a)
Mon2 16
Mon2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MON2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MON2 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mon2 35
  • 87.42 (n)
  • 95.31 (a)
chicken
(Gallus gallus)
Aves MON2 35
  • 83.53 (n)
  • 93.88 (a)
MON2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MON2 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mon2 35
  • 78.2 (n)
  • 89.11 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.391 35
zebrafish
(Danio rerio)
Actinopterygii LOC100334806 35
  • 71.34 (n)
  • 85.03 (a)
mon2 36
  • 83 (a)
OneToOne
wufc16c07 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009972 35
  • 54.94 (n)
  • 55.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta mon2 35
  • 54.82 (n)
  • 51.31 (a)
mon2 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mon-2 35
  • 48.28 (n)
  • 35.82 (a)
mon-2 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MON2 36
  • 20 (a)
OneToOne
Species with no ortholog for MON2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MON2 Gene

ENSEMBL:
Gene Tree for MON2 (if available)
TreeFam:
Gene Tree for MON2 (if available)

Paralogs for MON2 Gene

No data available for Paralogs for MON2 Gene

Variants for MON2 Gene

Sequence variations from dbSNP and Humsavar for MON2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs12357 -- 62,592,840(+) CTGCA(A/G)ATAAT utr-variant-3-prime, nc-transcript-variant
rs12510 -- 62,592,922(-) TTTGT(A/T)GATGT utr-variant-3-prime, nc-transcript-variant
rs732372 -- 62,542,974(+) TATAA(C/T)TTTAT intron-variant
rs774534 -- 62,590,299(-) cctgg(C/G)caaca intron-variant
rs810180 -- 62,584,869(-) aactt(C/T)tttcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MON2 Gene

Variant ID Type Subtype PubMed ID
dgv1433n71 CNV Loss 21882294
nsv821671 CNV Loss 15273396
nsv739 CNV Insertion 18451855
esv268651 CNV Insertion 20981092
esv274602 CNV Insertion 20981092
nsv469418 CNV Loss 19166990
esv2745966 CNV Deletion 23290073
esv2658375 CNV Deletion 23128226
nsv740 CNV Insertion 18451855

Relevant External Links for MON2 Gene

HapMap Linkage Disequilibrium report
MON2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MON2 Gene

Disorders for MON2 Gene

(2) University of Copenhagen DISEASES for MON2 Gene

genes like me logo Genes that share disorders with MON2: view

No data available for UniProtKB/Swiss-Prot for MON2 Gene

Publications for MON2 Gene

  1. Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus. (PMID: 16301316) Gillingham A.K. … Munro S. (J. Biol. Chem. 2006) 2 3 4
  2. Mammalian Mon2/Ysl2 regulates endosome-to-Golgi trafficking but possesses no guanine nucleotide exchange activity toward Arl1 GTPase. (PMID: 24285343) Mahajan D. … Lu L. (Sci Rep 2013) 2 3
  3. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3

Products for MON2 Gene

Sources for MON2 Gene

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