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Aliases for MON2 Gene

Aliases for MON2 Gene

  • MON2 Homolog, Regulator Of Endosome-To-Golgi Trafficking 2 3 5
  • MON2 Homolog (S. Cerevisiae) 2
  • MON2 Homolog (Yeast) 2
  • Protein SF21 4
  • KIAA1040 4
  • SF21 4

External Ids for MON2 Gene

Previous GeneCards Identifiers for MON2 Gene

  • GC12P061147
  • GC12P062860
  • GC12P059911

Summaries for MON2 Gene

GeneCards Summary for MON2 Gene

MON2 (MON2 Homolog, Regulator Of Endosome-To-Golgi Trafficking) is a Protein Coding gene. GO annotations related to this gene include binding and ARF guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for MON2 Gene

  • May be required for traffic between late Golgi and early endosomes.

Gene Wiki entry for MON2 Gene

Additional gene information for MON2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MON2 Gene

Genomics for MON2 Gene

Regulatory Elements for MON2 Gene

Enhancers for MON2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H062256 2.1 FANTOM5 Ensembl ENCODE dbSUPER 26.5 -207.1 -207087 6 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 MON2 ENSG00000257354 USP15 RPL14P1 FAM19A2 LINC01465 KLF17P1
GH12H062601 1.7 FANTOM5 ENCODE dbSUPER 21.7 +136.7 136720 4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 MON2 ENSG00000257354 USP15 FAM19A2 GC12P062607
GH12H062933 1.4 ENCODE dbSUPER 21.7 +467.7 467716 2 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B MON2 ENSG00000257354 TMEM5 PPM1H GC12M062851 RNU1-83P
GH12H062817 1.5 FANTOM5 Ensembl ENCODE 15.3 +351.3 351269 1 FEZF1 ZNF2 ZNF121 ATF7 ZNF202 REST TSHZ1 ZNF488 ZNF518A ZNF610 RNU1-83P MON2 ENSG00000257354 ENSG00000257568 PPM1H LOC105369795 GC12M062761
GH12H062319 1.1 FANTOM5 ENCODE dbSUPER 15 -147.5 -147525 0 ZNF202 CC2D1A POLR2A ZBTB33 TRIM24 CHAMP1 MON2 ENSG00000257354 USP15 ENSG00000257568 LINC01465 RNU6-595P GC12M062335 FAM19A2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MON2 on UCSC Golden Path with GeneCards custom track

Promoters for MON2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052977 584 3200 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 ZNF143

Genomic Location for MON2 Gene

Chromosome:
12
Start:
62,466,817 bp from pter
End:
62,600,479 bp from pter
Size:
133,663 bases
Orientation:
Plus strand

Genomic View for MON2 Gene

Genes around MON2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MON2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MON2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MON2 Gene

Proteins for MON2 Gene

  • Protein details for MON2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3U7-MON2_HUMAN
    Recommended name:
    Protein MON2 homolog
    Protein Accession:
    Q7Z3U7
    Secondary Accessions:
    • A5D8U7
    • A7E2Y0
    • B9EGP5
    • F8VWA6
    • F8W1Z6
    • Q86TA2
    • Q8N3I5
    • Q8NAI0
    • Q8NHE2
    • Q9UPW1

    Protein attributes for MON2 Gene

    Size:
    1717 amino acids
    Molecular mass:
    190359 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA82992.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MON2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MON2 Gene

Post-translational modifications for MON2 Gene

  • Ubiquitination at Lys281 and posLast=288288
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MON2 Gene

Domains & Families for MON2 Gene

Gene Families for MON2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MON2 Gene

Suggested Antigen Peptide Sequences for MON2 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z3U7

UniProtKB/Swiss-Prot:

MON2_HUMAN :
  • Belongs to the MON2 family.
Family:
  • Belongs to the MON2 family.
genes like me logo Genes that share domains with MON2: view

Function for MON2 Gene

Molecular function for MON2 Gene

UniProtKB/Swiss-Prot Function:
May be required for traffic between late Golgi and early endosomes.

Phenotypes From GWAS Catalog for MON2 Gene

Gene Ontology (GO) - Molecular Function for MON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14743216
genes like me logo Genes that share ontologies with MON2: view

Phenotypes for MON2 Gene

genes like me logo Genes that share phenotypes with MON2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MON2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MON2 Gene

Localization for MON2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MON2 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
endosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with MON2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MON2 Gene

Pathways & Interactions for MON2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006895 Golgi to endosome transport ISS --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with MON2: view

No data available for Pathways by source and SIGNOR curated interactions for MON2 Gene

Drugs & Compounds for MON2 Gene

No Compound Related Data Available

Transcripts for MON2 Gene

Unigene Clusters for MON2 Gene

MON2 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MON2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MON2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1: - -
SP2:
SP3:
SP4: - - - - -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 22b · 22c ^ 23a · 23b ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b
SP1:
SP2: - - -
SP3: - - - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:

Relevant External Links for MON2 Gene

GeneLoc Exon Structure for
MON2
ECgene alternative splicing isoforms for
MON2

Expression for MON2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MON2 Gene

Protein differential expression in normal tissues from HIPED for MON2 Gene

This gene is overexpressed in Bone (51.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MON2 Gene



Protein tissue co-expression partners for MON2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MON2 Gene:

MON2

SOURCE GeneReport for Unigene cluster for MON2 Gene:

Hs.389378

Evidence on tissue expression from TISSUES for MON2 Gene

  • Nervous system(4.6)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MON2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MON2 Gene

Orthologs for MON2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MON2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MON2 33 34
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia MON2 33 34
  • 94.2 (n)
oppossum
(Monodelphis domestica)
Mammalia MON2 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MON2 33 34
  • 93.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MON2 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mon2 33
  • 87.42 (n)
mouse
(Mus musculus)
Mammalia Mon2 33 16 34
  • 85.96 (n)
chicken
(Gallus gallus)
Aves MON2 33 34
  • 83.53 (n)
lizard
(Anolis carolinensis)
Reptilia MON2 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mon2 33
  • 78.2 (n)
zebrafish
(Danio rerio)
Actinopterygii mon2 34
  • 83 (a)
OneToOne
LOC100334806 33
  • 71.34 (n)
wufc16c07 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.391 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009972 33
  • 54.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta mon2 33 34
  • 54.82 (n)
worm
(Caenorhabditis elegans)
Secernentea mon-2 33 34
  • 48.28 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MON2 34
  • 20 (a)
OneToOne
Species where no ortholog for MON2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MON2 Gene

ENSEMBL:
Gene Tree for MON2 (if available)
TreeFam:
Gene Tree for MON2 (if available)

Paralogs for MON2 Gene

No data available for Paralogs for MON2 Gene

Variants for MON2 Gene

Sequence variations from dbSNP and Humsavar for MON2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000014020 -- 62,584,521(+) ACACA(A/G)TGAAA intron-variant
rs1000035362 -- 62,478,440(+) ACTGC(C/T)TATGA intron-variant
rs1000056895 -- 62,578,336(+) CCCCA(A/C)CCTGG intron-variant
rs1000115433 -- 62,522,698(+) GCCAC(C/T)TGGGG intron-variant
rs1000149349 -- 62,584,796(+) GACTA(A/G)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MON2 Gene

Variant ID Type Subtype PubMed ID
dgv822n106 CNV deletion 24896259
esv2658375 CNV deletion 23128226
esv2745966 CNV deletion 23290073
esv3549302 CNV deletion 23714750
esv3629738 CNV loss 21293372
nsv469418 CNV loss 19166990
nsv559156 CNV loss 21841781
nsv739 CNV insertion 18451855
nsv740 CNV insertion 18451855
nsv821671 CNV loss 15273396
nsv952196 CNV duplication 24416366

Variation tolerance for MON2 Gene

Residual Variation Intolerance Score: 5.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.08; 98.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MON2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MON2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MON2 Gene

Disorders for MON2 Gene

Relevant External Links for MON2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MON2

No disorders were found for MON2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MON2 Gene

Publications for MON2 Gene

  1. Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus. (PMID: 16301316) Gillingham AK … Munro S (The Journal of biological chemistry 2006) 2 3 4 60
  2. Mammalian Mon2/Ysl2 regulates endosome-to-Golgi trafficking but possesses no guanine nucleotide exchange activity toward Arl1 GTPase. (PMID: 24285343) Mahajan D … Lu L (Scientific reports 2013) 2 3 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for MON2 Gene

Sources for MON2 Gene

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