MON1B Gene
protein-coding GIFtS: 49
GCID: GC16P077224
|
|
MON1 homolog B (yeast)
| |
Aliases
for MON1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MON1 Homolog B (Yeast)1 2 | | HSV-1 Stimulation-Related Gene 1 Protein2 3 | | HSRG11 2 3 | | HSV-I Stimulating-Related Protein2 3 | | SAND21 2 3 | | SRG12 5 | | KIAA08721 3 5 | | Vacuolar Fusion Protein MON1 Homolog B2 |
Export aliases for MON1B gene to outside databasesPrevious GC identifers: GC16P075783 GC16P062981 |
Summaries
for MON1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for MON1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MON1B gene promoter:
AhR NRSF form 1 CUTL1 NRSF form 2 C/EBPalpha Arnt E47 CHOP-10 FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MON1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MON1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q23.1 Ensembl cytogenetic band: 16q23.1 HGNC cytogenetic band: 16q23.1MON1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P077224: view genomic region
(about GC identifiers)
Start:
|
77,224,732 bp from pter |
End:
|
77,236,302 bp from pter |
Size:
|
11,571 bases |
Orientation:
|
plus strand |
|
Proteins
for MON1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MON1B_HUMAN, Q7L1V2 (See
protein sequence)Recommended Name: Vacuolar fusion protein MON1 homolog B Size: 547 amino acids; 59217 Da
Secondary accessions: O94949Explore the universe of human proteins at neXtProt for MON1B: NX_Q7L1V2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7L1V2
MON1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055755.1
ENSEMBL proteins: ENSP00000456038 ENSP00000248248 ENSP00000457858 ENSP00000455376 ENSP00000457542 ENSP00000455641 ENSP00000404053 ENSP00000444881 ENSP00000324833
Human Recombinant Protein Products:
MON1B Antibody Products:
Assay Products for MON1B: |
Protein
Domains /
Families
for MON1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MON1B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7L1V2ProtoNet protein and cluster: Q7L1V2 1 Blocks protein family: IPB004353 Saccharomyces cerevisiae 73.5kDa hypothetical protein signature
UniProtKB/Swiss-Prot: MON1B_HUMAN, Q7L1V2Similarity: Belongs to the MON1/SAND family |
Function
for MON1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MON1B_HUMAN, Q7L1V2Induction: Induced in fibroblast KMB17 cells by HSV-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MON1B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MON1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MON1B (NM_014940) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MON1B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MON1B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MON1B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
MON1B for ontologies About GeneDecksing
|
Pathways & Interactions
for MON1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MON1B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/9 Interacting proteins for MON1B (Q7L1V21, 3 ENSP000002482484) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
|
Drugs & Compounds
for MON1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MON1B
Search CenterWatch for drugs/clinical trials and news about MON1B
|
Transcripts
for MON1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MON1B gene: NM_014940.2 Unigene Cluster for MON1B: MON1 homolog B (yeast) Hs.513743 [show with all ESTs]Unigene Representative Sequence: AB02067911 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000569610 ENST00000248248(uc002fez.3 uc010vnf.2 uc010vng.2)
ENST00000567291 ENST00000563612 ENST00000563279 ENST00000566963 ENST00000564006
ENST00000439557 ENST00000545553 ENST00000566455(uc002ffa.3) ENST00000320859
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MON1B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MON1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MON1B (NM_014940) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MON1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MON1B |
Additional cDNA sequence: AB020679.1 AF442486.1 AK023374.1 AK023896.1 AK293392.1 AK296467.1 BC024277.1 8 DOTS entries: DT.454740 DT.97845873 DT.100736117 DT.410177 DT.97837739 DT.120666081 DT.120666109 DT.95375547 24/254 AceView cDNA sequences (see all 254): AA258904 AA411034 BU501529 BQ647666 BX457718 BE464728 BM469754 AI422836 BQ071055 CA488947 BM837466 BC024277 NM_014940 AW002072 BP341212 BX345691 BU507596 BQ417312 AI298133 BM541667 BU185253 AI275496 AA025370 AA418719
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MON1B (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | · | 3f | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MON1B
|
Expression
for MON1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MON1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGTGCTGAAA
About this image
See MON1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MON1B
SOURCE GeneReport for Unigene cluster: Hs.513743
SABiosciences Custom PCR Arrays for MON1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MON1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MON1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MON1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MON1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MON1B |
Orthologs
for MON1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MON1B gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
MON1B6 |
-- |
63(a) |
1 ↔ 1 |
2(69101034-69109712) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.115282 |
Transcribed sequence with weak similarity to protein more |
74.42(n) |
|
BQ388616.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.269402 |
Transcribed sequence with weak similarity to protein more |
78.3(n) |
|
57081199 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG119266 |
-- |
32(a) |
1 → many |
2L(4850641-4852640) |
worm
(Caenorhabditis elegans) |
Secernentea |
sand-16 |
SAND endocytosis protein family member (sand-1) |
25(a) |
1 → many |
IV(5366857-5368858) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT2G283906 |
SAND family protein |
23(a) |
1 → many |
2(12139580-12143465) |
rice
(Oryza sativa) |
Liliopsida |
-- |
vacuolar fusion protein MON1 homolog A, putative, ... |
21(a) |
1 → many |
1(43119037-43124677) |
ENSEMBL Gene Tree for MON1B (if available)
TreeFam Gene Tree for MON1B (if available) |
Paralogs
for MON1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MON1B gene
- MON1A2
1 SIMAP similar gene for MON1B using alignment to 9 protein entries: MON1B_HUMAN (see all proteins):MON1A
MON1B for paralogs About GeneDecksing
|
Genomic Variants
for MON1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MON1B (77224732 - 77236302 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MON1B
1 CNV: 72619 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MON1B |
|
Disorders
/ Diseases
for MON1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MON1B for disorders About GeneDecksing
OMIM gene information: 608954
OMIM disorders: --
4  diseases for MON1B: About MalaCardsdetrusor sphincter dyssynergia herpes simplex cholesterol malaria
Human Genome Epidemiology (HuGE) Navigator: MON1B (3 documents)
Export disorders for MON1B gene to outside databases
|
Publications
for MON1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MON1B gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with MON1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
- Identification of a novel human MON1/SAND family protein in human fibroblasts induced by herpes simplex virus 1 binding. (PubMed id 12828340)1, 2, 9 Dong S.Z.... Li Q.H. (2003)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)
- Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)1 Dastani Z....Genest J. (2010)
- Protein encoded by HSV-1 stimulation-related gene 1 (HSRG1) interacts with and inhibits SV40 large T antigen. (PubMed id 17109635)1 Guo H.X....Li Q.H. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for MON1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MON1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MON1B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing MON1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MON1B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MON1B gene:
Search GeneIP for patents involving MON1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MON1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MON1B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MON1B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MON1B | | | OriGene Protein Over-expression Lysate for MON1B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MON1B | | OriGene 3'-UTR Clone for MON1B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MON1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MON1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MON1B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | | Search Tocris compounds for MON1B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MON1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MON1B |
|  |  |  | | | | Search ThermoFisher Antibodies for MON1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MON1B |
|
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