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Aliases for MON1B Gene

Aliases for MON1B Gene

  • MON1 Homolog B, Secretory Trafficking Associated 2 3 5
  • MON1 Secretory Trafficking Family Member B 2 3
  • HSV-1 Stimulation-Related Gene 1 Protein 3 4
  • HSV-I Stimulating-Related Protein 3 4
  • HSRG1 3 4
  • SAND2 3 4
  • Vacuolar Fusion Protein MON1 Homolog B 3
  • MON1 Homolog B (Yeast) 2
  • MON1 Homolog B 3
  • KIAA0872 4
  • SRG1 3

External Ids for MON1B Gene

Previous GeneCards Identifiers for MON1B Gene

  • GC16P075783
  • GC16P062981

Summaries for MON1B Gene

GeneCards Summary for MON1B Gene

MON1B (MON1 Homolog B, Secretory Trafficking Associated) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport. An important paralog of this gene is MON1A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MON1B Gene

Genomics for MON1B Gene

Regulatory Elements for MON1B Gene

Enhancers for MON1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F077211 1.2 Ensembl ENCODE 17.9 +22.4 22438 3.1 PKNOX1 SIN3A GLI4 GLIS2 FOS SP3 YY2 REST ZNF610 SMARCA4 SYCE1L MON1B VN2R10P
GH16F077190 1.1 ENCODE 12.2 +0.6 568 2.6 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 SYCE1L MON1B GC16P077193 PIR54148
GH16F077287 1.2 FANTOM5 Ensembl ENCODE 7.5 +98.6 98599 3.4 SCRT1 JUN BHLHE40 CEBPB MAX USF2 FEZF1 REST NR3C1 EP300 SYCE1L ENSG00000260922 MON1B ADAMTS18 ENSG00000261063 ENSG00000260701
GH16F077166 0.4 ENCODE 11.6 -25.4 -25431 0.7 POLR2A MON1B SYCE1L ENSG00000279856
GH16F077219 0.2 ENCODE 12.4 +28.8 28840 0.8 SYCE1L VN2R10P MON1B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MON1B on UCSC Golden Path with GeneCards custom track

Promoters for MON1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MON1B Gene

77,190,835 bp from pter
77,202,405 bp from pter
11,571 bases
Plus strand

Genomic View for MON1B Gene

Genes around MON1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MON1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MON1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MON1B Gene

Proteins for MON1B Gene

  • Protein details for MON1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vacuolar fusion protein MON1 homolog B
    Protein Accession:
    Secondary Accessions:
    • B4DDZ0
    • O94949

    Protein attributes for MON1B Gene

    547 amino acids
    Molecular mass:
    59217 Da
    Quaternary structure:
    • Interacts with CCNT2; downregulates CCNT2-mediated activation of viral promoters during herpes simplex virus 1/HHV-1 infection.

    Alternative splice isoforms for MON1B Gene


neXtProt entry for MON1B Gene

Post-translational modifications for MON1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MON1B Gene

Domains & Families for MON1B Gene

Suggested Antigen Peptide Sequences for MON1B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MON1/SAND family.
  • Belongs to the MON1/SAND family.
genes like me logo Genes that share domains with MON1B: view

No data available for Gene Families for MON1B Gene

Function for MON1B Gene

Molecular function for MON1B Gene

UniProtKB/Swiss-Prot Induction:
Induced in fibroblast KMB17 cells by HSV-1.

Gene Ontology (GO) - Molecular Function for MON1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20434987
genes like me logo Genes that share ontologies with MON1B: view
genes like me logo Genes that share phenotypes with MON1B: view

Animal Model Products

miRNA for MON1B Gene

miRTarBase miRNAs that target MON1B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MON1B Gene

Localization for MON1B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MON1B gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MON1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21509660
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with MON1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MON1B Gene

Pathways & Interactions for MON1B Gene

genes like me logo Genes that share pathways with MON1B: view

Pathways by source for MON1B Gene

2 Reactome pathways for MON1B Gene

Gene Ontology (GO) - Biological Process for MON1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport IBA --
GO:0019085 early viral transcription IDA 21509660
GO:0019086 late viral transcription IDA 21509660
genes like me logo Genes that share ontologies with MON1B: view

No data available for SIGNOR curated interactions for MON1B Gene

Transcripts for MON1B Gene

Unigene Clusters for MON1B Gene

MON1 homolog B (yeast):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MON1B Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP5: -
SP6: - -
SP7: - -
SP9: -

Relevant External Links for MON1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MON1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MON1B Gene

Protein differential expression in normal tissues from HIPED for MON1B Gene

This gene is overexpressed in Breast (33.0) and Peripheral blood mononuclear cells (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MON1B Gene

Protein tissue co-expression partners for MON1B Gene

NURSA nuclear receptor signaling pathways regulating expression of MON1B Gene:


SOURCE GeneReport for Unigene cluster for MON1B Gene:

genes like me logo Genes that share expression patterns with MON1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MON1B Gene

Orthologs for MON1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MON1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MON1B 34 35
  • 99.45 (n)
(Canis familiaris)
Mammalia MON1B 34 35
  • 88.34 (n)
(Rattus norvegicus)
Mammalia Mon1b 34
  • 85.46 (n)
(Mus musculus)
Mammalia Mon1b 34 16 35
  • 85.04 (n)
(Bos Taurus)
Mammalia MON1B 35
  • 77 (a)
(Monodelphis domestica)
Mammalia MON1B 35
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia MON1B 35
  • 48 (a)
(Anolis carolinensis)
Reptilia MON1B 35
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11528 34
(Danio rerio)
Actinopterygii wu:fc54b10 34
  • 63.14 (n)
MON1B (1 of 2) 35
  • 51 (a)
MON1B (2 of 2) 35
  • 46 (a)
Dr.26940 34
fruit fly
(Drosophila melanogaster)
Insecta CG11926 35
  • 33 (a)
(Caenorhabditis elegans)
Secernentea sand-1 35
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MON1 35
  • 18 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G28390 34
  • 44.72 (n)
(Oryza sativa)
Liliopsida Os01g0976000 34
  • 43.6 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
Species where no ortholog for MON1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MON1B Gene

Gene Tree for MON1B (if available)
Gene Tree for MON1B (if available)

Paralogs for MON1B Gene

Paralogs for MON1B Gene

(1) SIMAP similar genes for MON1B Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with MON1B: view

Variants for MON1B Gene

Sequence variations from dbSNP and Humsavar for MON1B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1019565 -- 77,195,862(+) ACTAA(C/T)GACCG intron-variant
rs1019566 -- 77,196,195(+) GAAGG(A/G)GGCCT intron-variant
rs111427041 -- 77,192,527(+) TGATG(A/G)TCATG intron-variant
rs111432160 -- 77,197,127(+) CCAGC(A/G)CTTTG intron-variant
rs11149970 -- 77,191,821(+) ATTGG(C/G)TGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MON1B Gene

Variant ID Type Subtype PubMed ID
nsv827756 CNV gain 20364138
nsv523187 CNV loss 19592680
nsv1115510 CNV duplication 24896259
nsv1065048 CNV gain 25217958
nsv1056676 CNV loss 25217958
nsv1055234 CNV gain 25217958
esv3639162 CNV gain 21293372
esv25858 CNV loss 19812545
dgv3027n100 CNV gain 25217958
dgv125n111 CNV duplication 26073780

Variation tolerance for MON1B Gene

Residual Variation Intolerance Score: 3.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MON1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MON1B Gene

Disorders for MON1B Gene

Relevant External Links for MON1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MON1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MON1B Gene

Publications for MON1B Gene

  1. Identification of a novel human MON1/SAND family protein in human fibroblasts induced by herpes simplex virus 1 binding. (PMID: 12828340) Dong S.Z. … Li Q.H. (Acta Virol. 2003) 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. HSV-1 stimulation-related protein HSRG1 inhibits viral gene transcriptional elongation by interacting with Cyclin T2. (PMID: 21509660) Wu W. … Li Q. (Sci China Life Sci 2011) 3 4 64
  4. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 46 64
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64

Products for MON1B Gene

Sources for MON1B Gene

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