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Aliases for MON1B Gene

Aliases for MON1B Gene

  • MON1 Homolog B, Secretory Trafficking Associated 2 3 5
  • MON1 Secretory Trafficking Family Member B 2 3
  • HSV-1 Stimulation-Related Gene 1 Protein 3 4
  • HSV-I Stimulating-Related Protein 3 4
  • HSRG1 3 4
  • SAND2 3 4
  • MON1 Homolog B (Yeast) 2
  • MON1 Homolog B 3
  • KIAA0872 4
  • SRG1 3

External Ids for MON1B Gene

Previous GeneCards Identifiers for MON1B Gene

  • GC16P075783
  • GC16P062981

Summaries for MON1B Gene

GeneCards Summary for MON1B Gene

MON1B (MON1 Homolog B, Secretory Trafficking Associated) is a Protein Coding gene. An important paralog of this gene is MON1A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MON1B Gene

Genomics for MON1B Gene

Regulatory Elements for MON1B Gene

Enhancers for MON1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MON1B on UCSC Golden Path with GeneCards custom track

Promoters for MON1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MON1B on UCSC Golden Path with GeneCards custom track

Genomic Location for MON1B Gene

Chromosome:
16
Start:
77,190,835 bp from pter
End:
77,202,405 bp from pter
Size:
11,571 bases
Orientation:
Plus strand

Genomic View for MON1B Gene

Genes around MON1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MON1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MON1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MON1B Gene

Proteins for MON1B Gene

  • Protein details for MON1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L1V2-MON1B_HUMAN
    Recommended name:
    Vacuolar fusion protein MON1 homolog B
    Protein Accession:
    Q7L1V2
    Secondary Accessions:
    • B4DDZ0
    • O94949

    Protein attributes for MON1B Gene

    Size:
    547 amino acids
    Molecular mass:
    59217 Da
    Quaternary structure:
    • Interacts with CCNT2; downregulates CCNT2-mediated activation of viral promoters during herpes simplex virus 1/HHV-1 infection.

    Alternative splice isoforms for MON1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MON1B Gene

Proteomics data for MON1B Gene at MOPED

Post-translational modifications for MON1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MON1B Gene

Domains & Families for MON1B Gene

Suggested Antigen Peptide Sequences for MON1B Gene

Graphical View of Domain Structure for InterPro Entry

Q7L1V2

UniProtKB/Swiss-Prot:

MON1B_HUMAN :
  • Belongs to the MON1/SAND family.
Family:
  • Belongs to the MON1/SAND family.
genes like me logo Genes that share domains with MON1B: view

No data available for Gene Families for MON1B Gene

Function for MON1B Gene

Molecular function for MON1B Gene

UniProtKB/Swiss-Prot Induction:
Induced in fibroblast KMB17 cells by HSV-1.
genes like me logo Genes that share phenotypes with MON1B: view

Animal Model Products

miRNA for MON1B Gene

miRTarBase miRNAs that target MON1B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MON1B Gene

Localization for MON1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MON1B Gene COMPARTMENTS Subcellular localization image for MON1B gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MON1B Gene

Pathways & Interactions for MON1B Gene

SuperPathways for MON1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MON1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport IBA --
GO:0019086 late viral transcription IDA 21509660
genes like me logo Genes that share ontologies with MON1B: view

No data available for Pathways by source and SIGNOR curated interactions for MON1B Gene

Drugs & Compounds for MON1B Gene

No Compound Related Data Available

Transcripts for MON1B Gene

Unigene Clusters for MON1B Gene

MON1 homolog B (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MON1B Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP5: -
SP6: - -
SP7: - -
SP8:
SP9: -

Relevant External Links for MON1B Gene

GeneLoc Exon Structure for
MON1B
ECgene alternative splicing isoforms for
MON1B

Expression for MON1B Gene

mRNA expression in normal human tissues for MON1B Gene

Protein differential expression in normal tissues from HIPED for MON1B Gene

This gene is overexpressed in Breast (33.0) and Peripheral blood mononuclear cells (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MON1B Gene



SOURCE GeneReport for Unigene cluster for MON1B Gene Hs.513743

genes like me logo Genes that share expression patterns with MON1B: view

Protein tissue co-expression partners for MON1B Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MON1B Gene

Orthologs for MON1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MON1B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MON1B 35
  • 88.34 (n)
  • 90.29 (a)
MON1B 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mon1b 35
  • 85.04 (n)
  • 88.46 (a)
Mon1b 16
Mon1b 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MON1B 35
  • 99.45 (n)
  • 99.63 (a)
MON1B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mon1b 35
  • 85.46 (n)
  • 90.64 (a)
cow
(Bos Taurus)
Mammalia MON1B 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MON1B 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MON1B 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MON1B 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11528 35
zebrafish
(Danio rerio)
Actinopterygii Dr.26940 35
wu:fc54b10 35
  • 63.14 (n)
  • 62.07 (a)
MON1B (1 of 2) 36
  • 51 (a)
OneToMany
MON1B (2 of 2) 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11926 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sand-1 36
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MON1 36
  • 18 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G28390 35
  • 44.72 (n)
  • 34.88 (a)
rice
(Oryza sativa)
Liliopsida Os01g0976000 35
  • 43.6 (n)
  • 33.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for MON1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MON1B Gene

ENSEMBL:
Gene Tree for MON1B (if available)
TreeFam:
Gene Tree for MON1B (if available)

Paralogs for MON1B Gene

Paralogs for MON1B Gene

(1) SIMAP similar genes for MON1B Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with MON1B: view

Variants for MON1B Gene

Sequence variations from dbSNP and Humsavar for MON1B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs13337946 -- 77,197,261(+) atgtg(A/G)tggca intron-variant
rs9930541 -- 77,189,128(+) gcaaa(C/G)ctgcc upstream-variant-2KB
rs4887893 -- 77,197,069(+) gagat(G/T)ggaat intron-variant
rs1019565 -- 77,195,862(+) ACTAA(C/T)GACCG intron-variant
rs1019566 -- 77,196,195(+) GAAGG(A/G)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MON1B Gene

Variant ID Type Subtype PubMed ID
dgv2918n71 CNV Gain 21882294
nsv827756 CNV Gain 20364138
esv25858 CNV Loss 19812545
nsv523187 CNV Loss 19592680

Variation tolerance for MON1B Gene

Residual Variation Intolerance Score: 3.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MON1B Gene

Disorders for MON1B Gene

Relevant External Links for MON1B

Genetic Association Database (GAD)
MON1B
Human Genome Epidemiology (HuGE) Navigator
MON1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MON1B

No disorders were found for MON1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MON1B Gene

Publications for MON1B Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. Identification of a novel human MON1/SAND family protein in human fibroblasts induced by herpes simplex virus 1 binding. (PMID: 12828340) Dong S.Z. … Li Q.H. (Acta Virol. 2003) 3 23
  3. Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients. (PMID: 24811271) Kennedy R.B. … Poland G.A. (Immunogenetics 2014) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. HSV-1 stimulation-related protein HSRG1 inhibits viral gene transcriptional elongation by interacting with Cyclin T2. (PMID: 21509660) Wu W. … Li Q. (Sci China Life Sci 2011) 3

Products for MON1B Gene

Sources for MON1B Gene

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