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Aliases for MON1A Gene

Aliases for MON1A Gene

  • MON1 Secretory Trafficking Family Member A 2 3
  • SAND1 3 4
  • Vacuolar Fusion Protein MON1 Homolog A 3
  • MON1 Homolog A (Yeast) 2
  • MON1 Homolog A 3

External Ids for MON1A Gene

Previous GeneCards Identifiers for MON1A Gene

  • GC03M049923

Summaries for MON1A Gene

GeneCards Summary for MON1A Gene

MON1A (MON1 Secretory Trafficking Family Member A) is a Protein Coding gene. Diseases associated with MON1A include syringomyelia. An important paralog of this gene is MON1B.

UniProtKB/Swiss-Prot for MON1A Gene

  • Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MON1A Gene

Genomics for MON1A Gene

Regulatory Elements for MON1A Gene

Genomic Location for MON1A Gene

Start:
49,908,862 bp from pter
End:
49,930,173 bp from pter
Size:
21,312 bases
Orientation:
Minus strand

Genomic View for MON1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MON1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MON1A Gene

Proteins for MON1A Gene

  • Protein details for MON1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VX9-MON1A_HUMAN
    Recommended name:
    Vacuolar fusion protein MON1 homolog A
    Protein Accession:
    Q86VX9
    Secondary Accessions:
    • B2RDQ1
    • G5E9N1
    • Q8NAV7
    • Q9BRF3

    Protein attributes for MON1A Gene

    Size:
    555 amino acids
    Molecular mass:
    62131 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47022.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MON1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MON1A Gene

Proteomics data for MON1A Gene at MOPED

Post-translational modifications for MON1A Gene

  • Ubiquitination at Lys166
  • Modification sites at PhosphoSitePlus

Other Protein References for MON1A Gene

Antibody Products

No data available for DME Specific Peptides for MON1A Gene

Domains for MON1A Gene

Protein Domains for MON1A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MON1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VX9

UniProtKB/Swiss-Prot:

MON1A_HUMAN :
  • Q86VX9
Family:
  • Belongs to the MON1/SAND family.
genes like me logo Genes that share domains with MON1A: view

No data available for Gene Families for MON1A Gene

Function for MON1A Gene

Molecular function for MON1A Gene

UniProtKB/Swiss-Prot Function:
Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity).

Phenotypes for MON1A Gene

GenomeRNAi human phenotypes for MON1A:
genes like me logo Genes that share phenotypes with MON1A: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MON1A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MON1A Gene

Localization for MON1A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MON1A Gene COMPARTMENTS Subcellular localization image for MON1A gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MON1A Gene

Pathways for MON1A Gene

SuperPathways for MON1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MON1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006879 cellular iron ion homeostasis --
GO:0009306 protein secretion --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with MON1A: view

No data available for Pathways by source for MON1A Gene

Transcripts for MON1A Gene

Unigene Clusters for MON1A Gene

MON1 homolog A (yeast):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MON1A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MON1A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9
SP1: - - - - -
SP2: - - - - - - - - - -
SP3: - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - -
SP7: - -

Relevant External Links for MON1A Gene

GeneLoc Exon Structure for
MON1A
ECgene alternative splicing isoforms for
MON1A

Expression for MON1A Gene

mRNA expression in normal human tissues for MON1A Gene

Protein differential expression in normal tissues for MON1A Gene

This gene is overexpressed in Testis (29.4), Fetal Brain (9.9), Retina (7.9), and Blymphocyte (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MON1A Gene

SOURCE GeneReport for Unigene cluster for MON1A Gene Hs.655014

genes like me logo Genes that share expressions with MON1A: view

Expression partners for MON1A Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MON1A Gene

Orthologs for MON1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MON1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MON1A 35
  • 90.57 (n)
  • 95.32 (a)
MON1A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MON1A 35
  • 92.31 (n)
  • 96.94 (a)
MON1A 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mon1a 35
  • 89.55 (n)
  • 94.23 (a)
Mon1a 16
Mon1a 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MON1A 35
  • 99.64 (n)
  • 99.69 (a)
MON1A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mon1a 35
  • 89.88 (n)
  • 94.88 (a)
oppossum
(Monodelphis domestica)
Mammalia MON1A 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MON1A 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves MON1A 35
  • 77.03 (n)
  • 80.26 (a)
MON1A 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MON1A 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mon1a 35
  • 64.63 (n)
  • 67.18 (a)
Str.16768 35
zebrafish
(Danio rerio)
Actinopterygii mon1a 35
  • 65.24 (n)
  • 64.91 (a)
mon1a 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009931 35
  • 50.98 (n)
  • 47.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11926 35
  • 53.73 (n)
  • 46.52 (a)
CG11926 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sand-1 35
  • 40.98 (n)
  • 30.05 (a)
sand-1 36
  • 26 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR175C 35
  • 47.2 (n)
  • 31.27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MON1 35
  • 38.69 (n)
  • 32.16 (a)
MON1 36
  • 21 (a)
OneToMany
MON1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU09220 35
  • 42.47 (n)
  • 33.65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for MON1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MON1A Gene

ENSEMBL:
Gene Tree for MON1A (if available)
TreeFam:
Gene Tree for MON1A (if available)

Paralogs for MON1A Gene

Paralogs for MON1A Gene

Selected SIMAP similar genes for MON1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MON1A: view

Variants for MON1A Gene

Sequence variations from dbSNP and Humsavar for MON1A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs868891 -- 49,911,638(-) AAGCC(C/T)GTGTA intron-variant, synonymous-codon, reference
rs1043591 -- 49,909,041(-) CGCCT(C/T)TTCAT reference, synonymous-codon
rs2352984 -- 49,911,295(+) CTCTC(C/T)CCAAA intron-variant
rs3177083 -- 49,908,870(-) GAAGA(A/C)ACTTG utr-variant-3-prime
rs6771546 -- 49,931,139(+) GCCAC(C/T)TGTAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MON1A Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV Loss 17160897
nsv876766 CNV Loss 21882294
nsv876767 CNV Loss 21882294
nsv834689 CNV Loss 17160897

Relevant External Links for MON1A Gene

HapMap Linkage Disequilibrium report
MON1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MON1A Gene

Disorders for MON1A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MON1A Gene in MalaCards »

(1) Diseases for MON1A Gene including...

(1) University of Copenhagen DISEASES for MON1A Gene

Relevant External Links for MON1A

Genetic Association Database (GAD)
MON1A
Human Genome Epidemiology (HuGE) Navigator
MON1A
genes like me logo Genes that share disorders with MON1A: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for MON1A Gene

Publications for MON1A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3
  4. Identification of the switch in early-to-late endosome transition. (PMID: 20434987) Poteryaev D. … Spang A. (Cell 2010) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for MON1A Gene

Sources for MON1A Gene

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