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Aliases for MON1A Gene

Aliases for MON1A Gene

  • MON1 Homolog A, Secretory Trafficking Associated 2 3 5
  • MON1 Secretory Trafficking Family Member A 2 3
  • SAND1 3 4
  • MON1 Homolog A (Yeast) 2
  • MON1 Homolog A 3

External Ids for MON1A Gene

Previous GeneCards Identifiers for MON1A Gene

  • GC03M049923

Summaries for MON1A Gene

GeneCards Summary for MON1A Gene

MON1A (MON1 Homolog A, Secretory Trafficking Associated) is a Protein Coding gene. Diseases associated with MON1A include Space Motion Sickness and Pilomyxoid Astrocytoma. An important paralog of this gene is MON1B.

UniProtKB/Swiss-Prot for MON1A Gene

  • Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MON1A Gene

Genomics for MON1A Gene

Regulatory Elements for MON1A Gene

Enhancers for MON1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MON1A on UCSC Golden Path with GeneCards custom track

Promoters for MON1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MON1A on UCSC Golden Path with GeneCards custom track

Genomic Location for MON1A Gene

49,908,862 bp from pter
49,930,357 bp from pter
21,496 bases
Minus strand

Genomic View for MON1A Gene

Genes around MON1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MON1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MON1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MON1A Gene

Proteins for MON1A Gene

  • Protein details for MON1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vacuolar fusion protein MON1 homolog A
    Protein Accession:
    Secondary Accessions:
    • B2RDQ1
    • G5E9N1
    • Q8NAV7
    • Q9BRF3

    Protein attributes for MON1A Gene

    555 amino acids
    Molecular mass:
    62131 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH47022.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MON1A Gene


neXtProt entry for MON1A Gene

Proteomics data for MON1A Gene at MOPED

Post-translational modifications for MON1A Gene

  • Ubiquitination at Lys 166
  • Modification sites at PhosphoSitePlus

Other Protein References for MON1A Gene

No data available for DME Specific Peptides for MON1A Gene

Domains & Families for MON1A Gene

Protein Domains for MON1A Gene


Suggested Antigen Peptide Sequences for MON1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MON1/SAND family.
  • Belongs to the MON1/SAND family.
genes like me logo Genes that share domains with MON1A: view

No data available for Gene Families for MON1A Gene

Function for MON1A Gene

Molecular function for MON1A Gene

UniProtKB/Swiss-Prot Function:
Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity).
genes like me logo Genes that share phenotypes with MON1A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MON1A Gene

Localization for MON1A Gene

Subcellular locations from

Jensen Localization Image for MON1A Gene COMPARTMENTS Subcellular localization image for MON1A gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
extracellular 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MON1A Gene

Pathways & Interactions for MON1A Gene

SuperPathways for MON1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MON1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009306 protein secretion IBA --
genes like me logo Genes that share ontologies with MON1A: view

No data available for Pathways by source and SIGNOR curated interactions for MON1A Gene

Drugs & Compounds for MON1A Gene

No Compound Related Data Available

Transcripts for MON1A Gene

Unigene Clusters for MON1A Gene

MON1 homolog A (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MON1A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9
SP1: - - - - -
SP2: - - - - - - - - - -
SP3: - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - -
SP7: - -

Relevant External Links for MON1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MON1A Gene

mRNA expression in normal human tissues for MON1A Gene

Protein differential expression in normal tissues from HIPED for MON1A Gene

This gene is overexpressed in Testis (29.4), Fetal Brain (9.9), Retina (7.9), and Blymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MON1A Gene

SOURCE GeneReport for Unigene cluster for MON1A Gene Hs.655014

genes like me logo Genes that share expression patterns with MON1A: view

Protein tissue co-expression partners for MON1A Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MON1A Gene

Orthologs for MON1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MON1A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MON1A 35
  • 90.57 (n)
  • 95.32 (a)
MON1A 36
  • 96 (a)
(Canis familiaris)
Mammalia MON1A 35
  • 92.31 (n)
  • 96.94 (a)
MON1A 36
  • 97 (a)
(Mus musculus)
Mammalia Mon1a 35
  • 89.55 (n)
  • 94.23 (a)
Mon1a 16
Mon1a 36
  • 94 (a)
(Pan troglodytes)
Mammalia MON1A 35
  • 99.64 (n)
  • 99.69 (a)
MON1A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mon1a 35
  • 89.88 (n)
  • 94.88 (a)
(Monodelphis domestica)
Mammalia MON1A 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia MON1A 36
  • 84 (a)
(Gallus gallus)
Aves MON1A 35
  • 77.03 (n)
  • 80.26 (a)
MON1A 36
  • 79 (a)
(Anolis carolinensis)
Reptilia MON1A 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mon1a 35
  • 64.63 (n)
  • 67.18 (a)
Str.16768 35
(Danio rerio)
Actinopterygii mon1a 35
  • 65.24 (n)
  • 64.91 (a)
mon1a 36
  • 62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009931 35
  • 50.98 (n)
  • 47.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11926 35
  • 53.73 (n)
  • 46.52 (a)
CG11926 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea sand-1 35
  • 40.98 (n)
  • 30.05 (a)
sand-1 36
  • 26 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR175C 35
  • 47.2 (n)
  • 31.27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MON1 35
  • 38.69 (n)
  • 32.16 (a)
MON1 36
  • 21 (a)
MON1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU09220 35
  • 42.47 (n)
  • 33.65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for MON1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MON1A Gene

Gene Tree for MON1A (if available)
Gene Tree for MON1A (if available)

Paralogs for MON1A Gene

Paralogs for MON1A Gene

(1) SIMAP similar genes for MON1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MON1A: view

Variants for MON1A Gene

Sequence variations from dbSNP and Humsavar for MON1A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs9832356 -- 49,927,353(+) atgaa(A/G)taatc intron-variant
rs6771546 -- 49,931,139(+) GCCAC(C/T)TGTAG upstream-variant-2KB
rs17050885 -- 49,928,252(+) GAAGC(A/C)AACAG intron-variant
rs11278644 -- 49,929,320(+) AATAT(-/GTGTAC)GTTTG intron-variant, upstream-variant-2KB
rs34287901 -- 49,931,614(+) GAGGG(-/AGGA)AGGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MON1A Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV Loss 17160897
nsv876766 CNV Loss 21882294
nsv876767 CNV Loss 21882294
nsv834689 CNV Loss 17160897

Variation tolerance for MON1A Gene

Residual Variation Intolerance Score: 7.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MON1A Gene

Disorders for MON1A Gene

MalaCards: The human disease database

(2) MalaCards diseases for MON1A Gene - From: DISEASES

Disorder Aliases PubMed IDs
space motion sickness
pilomyxoid astrocytoma
- elite association - COSMIC cancer census association via MalaCards
Search MON1A in MalaCards View complete list of genes associated with diseases

Relevant External Links for MON1A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MON1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MON1A Gene

Publications for MON1A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for MON1A Gene

Sources for MON1A Gene