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MON1A Gene

protein-coding   GIFtS: 52
GCID: GC03M049946

MON1 Secretory Trafficking Family Member A

(Previous name: MON1 homolog A (yeast))
  See MON1A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MON1 Secretory Trafficking Family Member A1 2
SAND12 3
MON1 Homolog A (Yeast)1
MON1 Homolog A2
Vacuolar Fusion Protein MON1 Homolog A2

External Ids:    HGNC: 282071   Entrez Gene: 843152   Ensembl: ENSG000001640777   OMIM: 6114645   UniProtKB: Q86VX93   

Export aliases for MON1A gene to outside databases

Previous GC identifer: GC03M049923


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MON1A Gene:
MON1A (MON1 secretory trafficking family member A) is a protein-coding gene. Diseases associated with MON1A include syringomyelia. An important paralog of this gene is MON1B.

UniProtKB/Swiss-Prot: MON1A_HUMAN, Q86VX9
Function: Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic
trafficking to lysosomes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MON1A gene promoter:
         STAT1   STAT4   STAT1beta   Tal-1beta   STAT1alpha   E47   Gfi-1   AREB6   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMON1A promoter sequence
   Search Chromatin IP Primers for MON1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MON1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

MON1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MON1A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049946:  view genomic region     (about GC identifiers)

Start:
49,946,302 bp from pter      End:
49,967,606 bp from pter
Size:
21,305 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MON1A_HUMAN, Q86VX9 (See protein sequence)
Recommended Name: Vacuolar fusion protein MON1 homolog A  
Size: 555 amino acids; 62131 Da
Sequence caution: Sequence=AAH47022.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RDQ1 G5E9N1 Q8NAV7 Q9BRF3
Alternative splicing: 4 isoforms:  Q86VX9-1   Q86VX9-2   Q86VX9-3   Q86VX9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MON1A: NX_Q86VX9

Explore proteomics data for MON1A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys166
  • Modification sites at PhosphoSitePlus

  • See MON1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135973.1  NP_115731.2  

    ENSEMBL proteins: 
     ENSP00000296473   ENSP00000404793   ENSP00000399613  

    MON1A Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MON1A

     
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    Search eBioscience for ELISAs for MON1A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004353 Vacuolar_fusion_protein_MON1

    Graphical View of Domain Structure for InterPro Entry Q86VX9

    ProtoNet protein and cluster: Q86VX9

    UniProtKB/Swiss-Prot: MON1A_HUMAN, Q86VX9
    Similarity: Belongs to the MON1/SAND family


    Find genes that share domains with MON1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MON1A_HUMAN, Q86VX9
    Function: Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic
    trafficking to lysosomes (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for MON1A:

     Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MON1A
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    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate MON1A:
    hsa-miR-2114 hsa-miR-155
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MON1A

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MON1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    cytoskeleton1
    endoplasmic reticulum1
    endosome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MON1A
    Interactions:

        Search GeneGlobe Interaction Network for MON1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MON1A (Q86VX92, 3 ENSP000002964734) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2877075 I2D: score=3 STRING: ENSP00000344782
    MAPK6Q166592, 3MINT-8261494 I2D: score=2 
    RGS2P412202, 3MINT-8268856 I2D: score=2 
    TAB1Q157502, 3MINT-8260207 I2D: score=2 
    PAN3Q58A453, ENSP000002823914I2D: score=6 STRING: ENSP00000282391
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006879cellular iron ion homeostasis ----
    GO:0009306protein secretion ----
    GO:0015031protein transport ----

    Find genes that share ontologies with MON1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MON1A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MON1A gene (2 alternative transcripts): 
    NM_001142501.1  NM_032355.3  

    Unigene Cluster for MON1A:

    MON1 homolog A (yeast)
    Hs.655014  [show with all ESTs]
    Unigene Representative Sequence: NM_032355
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296473(uc003cxz.3 uc003cya.3) ENST00000455683 ENST00000417270
    ENST00000486107(uc003cyb.2) ENST00000484985 ENST00000483022 ENST00000493206
    ENST00000473451(uc010hlb.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MON1A using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MON1A:
    hsa-miR-2114 hsa-miR-155
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MON1A
    Clone
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    OriGene ORF clones in mouse, rat for MON1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MON1A (NM_032355)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MON1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MON1A
    Primer
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    OriGene qPCR primer pairs and template standards for MON1A
    OriGene qSTAR qPCR primer pairs in human, mouse for MON1A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MON1A
      QuantiTect SYBR Green Assays in human, mouse, rat MON1A
      QuantiFast Probe-based Assays in human, mouse, rat MON1A

    Additional mRNA sequence: 

    AK074404.1 AK315630.1 BC006299.2 BC009459.1 BC047022.1 

    5 DOTS entries:

    DT.444803  DT.100022801  DT.91698873  DT.95271890  DT.91698865 

    Selected AceView cDNA sequences (see all 102):

    BC009459 NM_032355 CD671586 CR626253 AA827387 BC006299 BI838292 AK092018 
    BE793894 BC047022 CR598615 BU902545 BI084332 AX747314 BM927576 BU624538 
    BQ920648 BM919930 BX390046 BX342303 BE794741 BM801023 BX405011 AI910822 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MON1A (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9
    SP1:                          -     -     -     -     -                                                         
    SP2:                          -     -     -     -     -           -     -     -     -     -                     
    SP3:                          -     -     -     -                                                               
    SP4:                                                  -                                                         
    SP5:                          -     -     -     -     -           -     -     -     -     -                     


    ECgene alternative splicing isoforms for MON1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MON1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTACAGCC
    MON1A Expression
    About this image

    MON1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MON1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655014
        Custom PCR Arrays for MON1A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MON1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MON1A gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mon1a1 , 5 MON1 homolog A (yeast)1, 5 89.55(n)1
    94.23(a)1
      9 (59.07 cM)5
    728251  NM_028369.31  NP_082645.11 
     1078881295 
    chicken
    (Gallus gallus)
    Aves MON1A1 MON1 homolog A (yeast) 77.03(n)
    80.26(a)
      415929  XM_003641966.2  XP_003642014.1 
    lizard
    (Anolis carolinensis)
    Reptilia MON1A6
    MON1 secretory trafficking family member A
    73(a)
    1 ↔ 1
    2(147975937-147993932)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.167682 Transcribed sequence with moderate similarity to protein more 75.33(n)    AL849442.2 
    zebrafish
    (Danio rerio)
    Actinopterygii mon1a1 MON1 homolog A (yeast) 65.24(n)
    64.91(a)
      100073333  NM_001098770.1  NP_001092240.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG119261 CG11926 53.73(n)
    46.52(a)
      33689  NM_135024.2  NP_608868.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sand-11 sand-1 40.98(n)
    30.05(a)
      177318  NM_068390.6  NP_500791.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MON1(YGL124C)4
    MON11
    Protein required for fusion of cvt-vesicles and autophagosomes more4
    MON11
    38.69(n)1
    32.16(a)1
      7(276714-274780)4
    8527531, 4  NP_011391.21  NP_011391.14 


    ENSEMBL Gene Tree for MON1A (if available)
    TreeFam Gene Tree for MON1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MON1A gene
    MON1B2  
    1 SIMAP similar gene for MON1A using alignment to 1 protein entry:     MON1A_HUMAN:
    MON1B

    Find genes that share paralogs with MON1A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MON1A (see all 400)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1408673721,2
    C--49945862(+) TACCAA/GGGCTC 2 -- int10--------
    rs1431135971,2
    C--49945879(+) CCCCCA/GTTTTG 2 -- int10--------
    rs799201571,2
    F--49945950(+) CACAGC/TGAGGG 2 -- int11Minor allele frequency- T:0.02WA 118
    rs580259241,2
    C--49945996(+) AGCAGG/AGGGCC 2 -- int14Minor allele frequency- A:0.09NA WA EA 360
    rs2000084291,2
    --49946018(+) TGATA-/AGAGAGG 2 -- int10--------
    rs1886622391,2
    --49946086(+) TGCCTA/GAGAAC 2 -- int10--------
    rs2015434331,2
    --49946449(+) CCATCA/GATAGG 4 R * stop-lost0--------
    rs2009761091,2
    C--49946481(-) GGAAGA/CCCGCC 4 D A mis10--------
    rs2006193391,2
    F--49946577(+) CAAAGG/ACGCCT 4 /A /V mis11Minor allele frequency- A:0.01EU 647
    rs1928210951,2
    C--49946579(+) AAGGCA/GCCTGT 4 G syn10--------

    HapMap Linkage Disequilibrium report for MON1A (49946302 - 49967606 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MON1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876767CNV Loss21882294
    nsv876766CNV Loss21882294
    nsv834688CNV Loss17160897
    nsv834689CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MON1A
    DNA2.0 Custom Variant and Variant Library Synthesis for MON1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611464    OMIM disorders: --

    1 disease for MON1A:    
    About MalaCards
    syringomyelia

    1 disease from the University of Copenhagen DISEASES database for MON1A:
    Syringomyelia

    Find genes that share disorders with MON1A           About GenesLikeMe

    Genetic Association Database (GAD): MON1A
    Human Genome Epidemiology (HuGE) Navigator: MON1A (1 document)

    Export disorders for MON1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MON1A gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with MON1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Mon1a protein acts in trafficking through the secretory apparatus. (PubMed id 22665492)1 Bagley D.C....Ward D.M. (J. Biol. Chem. 2012)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    6. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    7. Identification of the switch in early-to-late endosome transition. (PubMed id 20434987)1 Poteryaev D....Spang A. (Cell 2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84315 HGNC: 28207 AceView: MGC13272 Ensembl:ENSG00000164077 euGenes: HUgn84315
    ECgene: MON1A H-InvDB: MON1A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MON1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MON1A gene:
    Search GeneIP for patents involving MON1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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