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Aliases for MOK Gene

Aliases for MOK Gene

  • MOK Protein Kinase 2 3 4 5
  • Renal Tumor Antigen 1 3 4
  • RAGE-1 3 4
  • RAGE1 3 4
  • RAGE 3 4
  • MAPK/MAK/MRK Overlapping Kinase 3
  • Renal Cell Carcinoma Antigen 3
  • Renal Tumor Antigen 2
  • EC 2.7.11.22 4
  • STK30 3

External Ids for MOK Gene

Previous HGNC Symbols for MOK Gene

  • RAGE

Previous GeneCards Identifiers for MOK Gene

  • GC14M102690

Summaries for MOK Gene

Entrez Gene Summary for MOK Gene

  • This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for MOK Gene

MOK (MOK Protein Kinase) is a Protein Coding gene. Diseases associated with MOK include Renal Cell Carcinoma and Kidney Cancer. Among its related pathways are IL-2 Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ICK.

UniProtKB/Swiss-Prot for MOK Gene

  • Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.

Gene Wiki entry for MOK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOK Gene

Genomics for MOK Gene

Regulatory Elements for MOK Gene

Enhancers for MOK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F102262 1.2 Ensembl ENCODE 27.2 +41.4 41387 3.3 ELF3 ZFP64 DMAP1 THRB ZNF48 RARA ZNF121 SCRT2 MIXL1 ZNF202 MOK CINP TECPR2 HSP90AA1 WDR20 GC14P102745 GC14P102750
GH14F102522 1.8 FANTOM5 Ensembl ENCODE 15.9 -220.9 -220894 6.2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 RCOR1 TECPR2 RPL23AP11 MOK ANKRD9 TRAF3 DIO3 ENSG00000271780 RNU6-244P DIO3OS
GH14F102254 1 Ensembl ENCODE 26.6 +49.4 49353 3.1 BCOR BACH1 ZNF316 PRDM10 FOS NFE2 MAFK NFE2L2 MAFG DPF2 MOK HSP90AA1 WDR20 GC14P102745 GC14P102750
GH14F102179 1.2 Ensembl ENCODE 21.4 +123.6 123613 3.6 HDAC1 ATF1 PKNOX1 TBL1XR1 ARNT ZEB1 GATA2 ZNF366 SCRT2 CREM MOK HSP90AA1 WDR20 ZNF839 LOC105370677
GH14F102184 1.2 Ensembl ENCODE 21 +118.7 118700 4.2 PKNOX1 ARID4B SIN3A ZNF121 FOS SP5 ZHX2 PPARG ATF4 SMARCA4 MOK HSP90AA1 WDR20 LOC105370677
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MOK on UCSC Golden Path with GeneCards custom track

Promoters for MOK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000424036 400 2001 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 GLIS2 ELK1 KLF7

Genomic Location for MOK Gene

Chromosome:
14
Start:
102,224,450 bp from pter
End:
102,305,200 bp from pter
Size:
80,751 bases
Orientation:
Minus strand

Genomic View for MOK Gene

Genes around MOK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOK Gene

Proteins for MOK Gene

  • Protein details for MOK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ07-MOK_HUMAN
    Recommended name:
    MAPK/MAK/MRK overlapping kinase
    Protein Accession:
    Q9UQ07
    Secondary Accessions:
    • B2R6Z4
    • B7Z7P6
    • E7ER76
    • E7ERR8
    • Q92790
    • Q93067

    Protein attributes for MOK Gene

    Size:
    419 amino acids
    Molecular mass:
    48014 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB38087.1; Type=Frameshift; Positions=299; Evidence={ECO:0000305};

    Alternative splice isoforms for MOK Gene

neXtProt entry for MOK Gene

Post-translational modifications for MOK Gene

No data available for DME Specific Peptides for MOK Gene

Domains & Families for MOK Gene

Gene Families for MOK Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQ07

UniProtKB/Swiss-Prot:

MOK_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with MOK: view

Function for MOK Gene

Molecular function for MOK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation appears to increase the enzymatic activity.
UniProtKB/Swiss-Prot Function:
Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.

Enzyme Numbers (IUBMB) for MOK Gene

Gene Ontology (GO) - Molecular Function for MOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,TAS 10421840
GO:0004674 protein serine/threonine kinase activity IEA,TAS 10421840
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with MOK: view
genes like me logo Genes that share phenotypes with MOK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MOK

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MOK Gene

Localization for MOK Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOK Gene

Cytoplasm. Cell projection, cilium. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOK gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 3
golgi apparatus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA,TAS --
GO:0005929 cilium ISS --
GO:0042995 cell projection IEA --
GO:0097546 ciliary base ISS --
genes like me logo Genes that share ontologies with MOK: view

Pathways & Interactions for MOK Gene

SuperPathway Contained pathways
1 IL-2 Pathway
genes like me logo Genes that share pathways with MOK: view

Pathways by source for MOK Gene

1 Qiagen pathway for MOK Gene

Gene Ontology (GO) - Biological Process for MOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 10421840
GO:0016310 phosphorylation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with MOK: view

No data available for SIGNOR curated interactions for MOK Gene

Drugs & Compounds for MOK Gene

(1) Drugs for MOK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MOK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MOK: view

Transcripts for MOK Gene

Unigene Clusters for MOK Gene

MOK protein kinase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5:
SP6: - - - - -
SP7: - - - -
SP8: - - - -
SP9:
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SP14: - - - -
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SP16: - - - -
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SP24:
SP25:
SP26: - - -
SP27: - - - - - - - -
SP28: - - - -
SP29:
SP30:
SP31:
SP32:
SP33:
SP34:

ExUns: 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f ^ 17a · 17b ^ 18a · 18b · 18c · 18d ^ 19a · 19b ^ 20a · 20b ·
SP1: - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - - - - - - - - - - - - - - -
SP15: - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - - - - - - -
SP20: - - - - - - - - - - - - - - - -
SP21: - - - - - - - - - -
SP22: - - - - - - - - - - - - -
SP23: - - - - - - - - -
SP24: - - - - - - - - -
SP25: - - - - - - - - - - - - - - - - - - -
SP26:
SP27: - - - - - - - - - - - - - - - - - - - - - - - - -
SP28: - - - - - - - - - - - - - - - - - - - - - - -
SP29: - - - - - -
SP30: - - - -
SP31: - - - - - - -
SP32: - -
SP33:
SP34: - - - - - - - - - - -

ExUns: 20c · 20d · 20e · 20f · 20g · 20h ^ 21a · 21b · 21c · 21d · 21e · 21f ^ 22 ^ 23a · 23b · 23c ^ 24
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6:
SP7:
SP8:
SP9: - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - -
SP12:
SP13:
SP14: - - - -
SP15:
SP16: - - - - - - - - - - - - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22: - - - - - - - - - - - - -
SP23:
SP24:
SP25:
SP26:
SP27: - - - - - - - - - - - - -
SP28:
SP29:
SP30:
SP31:
SP32: - - - - - - - - - - - -
SP33:
SP34:

Relevant External Links for MOK Gene

GeneLoc Exon Structure for
MOK
ECgene alternative splicing isoforms for
MOK

Expression for MOK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MOK Gene

mRNA differential expression in normal tissues according to GTEx for MOK Gene

This gene is overexpressed in Testis (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of MOK Gene:

MOK

SOURCE GeneReport for Unigene cluster for MOK Gene:

Hs.104119

mRNA Expression by UniProt/SwissProt for MOK Gene:

Q9UQ07-MOK_HUMAN
Tissue specificity: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.
genes like me logo Genes that share expression patterns with MOK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MOK Gene

Orthologs for MOK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAGE 34
  • 99.36 (n)
MOK 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mok 34
  • 91.13 (n)
dog
(Canis familiaris)
Mammalia MOK 34 35
  • 87.5 (n)
mouse
(Mus musculus)
Mammalia Stk30 34 35
  • 83.57 (n)
Mok 16
cow
(Bos Taurus)
Mammalia MOK 34 35
  • 83.45 (n)
oppossum
(Monodelphis domestica)
Mammalia MOK 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MOK 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOK 34 35
  • 68.75 (n)
lizard
(Anolis carolinensis)
Reptilia MOK 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mok 34
  • 67.53 (n)
Str.2425 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.10381 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002515 34
  • 49.12 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IME2 35
  • 18 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.27829 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 63 (a)
OneToOne
Species where no ortholog for MOK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MOK Gene

ENSEMBL:
Gene Tree for MOK (if available)
TreeFam:
Gene Tree for MOK (if available)

Paralogs for MOK Gene

Variants for MOK Gene

Sequence variations from dbSNP and Humsavar for MOK Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_042015 A breast pleomorphic lobular carcinoma sample
rs10047840 -- 102,236,864(+) acacc(A/G)ccatc intron-variant
rs10130085 -- 102,230,609(+) ATGCC(A/G)GCCAG intron-variant
rs10131302 -- 102,295,861(+) ctggg(C/T)gtgat intron-variant
rs10133613 -- 102,269,846(+) acacc(C/T)tactc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOK Gene

Variant ID Type Subtype PubMed ID
esv22037 CNV gain 19812545
esv2659155 CNV deletion 23128226
esv3366828 CNV insertion 20981092
esv3635547 CNV gain 21293372
esv3635549 CNV loss 21293372
nsv1429 CNV deletion 18451855
nsv1116755 CNV tandem duplication 24896259
esv3635554 CNV loss 21293372
esv3635553 CNV gain 21293372
esv3635552 CNV loss 21293372
esv3635551 CNV loss 21293372
esv3635550 CNV loss 21293372

Variation tolerance for MOK Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.38; 90.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOK Gene

Disorders for MOK Gene

MalaCards: The human disease database

(2) MalaCards diseases for MOK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
kidney cancer
  • malignant neoplasm of kidney except pelvis
- elite association - COSMIC cancer census association via MalaCards
Search MOK in MalaCards View complete list of genes associated with diseases

Relevant External Links for MOK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOK
genes like me logo Genes that share disorders with MOK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOK Gene

Publications for MOK Gene

  1. Molecular cloning and characterization of a novel member of the MAP kinase superfamily. (PMID: 10421840) Miyata Y. … Nishida E. (Genes Cells 1999) 2 3 4 64
  2. A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma. (PMID: 8781117) Gaugler B. … Van den Eynde B.J. (Immunogenetics 1996) 2 3 4 64
  3. Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma. (PMID: 17549666) Stav D. … Sandbank J. (Int. J. Biol. Markers 2007) 3 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells. (PMID: 15327990) Uesaka T. … Kageyama N. (FEBS Lett. 2004) 3 22 64

Products for MOK Gene

Sources for MOK Gene

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