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Aliases for MOK Gene

Aliases for MOK Gene

  • MOK Protein Kinase 2 3 4 5
  • Renal Tumor Antigen 1 3 4
  • RAGE-1 3 4
  • RAGE1 3 4
  • RAGE 3 4
  • Renal Cell Carcinoma Antigen 3
  • Renal Tumor Antigen 2
  • EC 2.7.11.22 4
  • STK30 3

External Ids for MOK Gene

Previous HGNC Symbols for MOK Gene

  • RAGE

Previous GeneCards Identifiers for MOK Gene

  • GC14M102690

Summaries for MOK Gene

Entrez Gene Summary for MOK Gene

  • This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for MOK Gene

MOK (MOK Protein Kinase) is a Protein Coding gene. Diseases associated with MOK include renal cell carcinoma and kidney cancer. Among its related pathways are IL-2 Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAK.

UniProtKB/Swiss-Prot for MOK Gene

  • Able to phosphorylate several exogenous substrates and to undergo autophosphorylation.

Gene Wiki entry for MOK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOK Gene

Genomics for MOK Gene

Regulatory Elements for MOK Gene

Promoters for MOK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MOK on UCSC Golden Path with GeneCards custom track

Genomic Location for MOK Gene

Chromosome:
14
Start:
102,224,450 bp from pter
End:
102,305,200 bp from pter
Size:
80,751 bases
Orientation:
Minus strand

Genomic View for MOK Gene

Genes around MOK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOK Gene

Proteins for MOK Gene

  • Protein details for MOK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ07-MOK_HUMAN
    Recommended name:
    MAPK/MAK/MRK overlapping kinase
    Protein Accession:
    Q9UQ07
    Secondary Accessions:
    • B2R6Z4
    • B7Z7P6
    • E7ER76
    • E7ERR8
    • Q92790
    • Q93067

    Protein attributes for MOK Gene

    Size:
    419 amino acids
    Molecular mass:
    48014 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB38087.1; Type=Frameshift; Positions=299; Evidence={ECO:0000305};

    Alternative splice isoforms for MOK Gene

neXtProt entry for MOK Gene

Proteomics data for MOK Gene at MOPED

Post-translational modifications for MOK Gene

Antibody Products

No data available for DME Specific Peptides for MOK Gene

Domains & Families for MOK Gene

Gene Families for MOK Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQ07

UniProtKB/Swiss-Prot:

MOK_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with MOK: view

Function for MOK Gene

Molecular function for MOK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation appears to increase the enzymatic activity.
UniProtKB/Swiss-Prot Function:
Able to phosphorylate several exogenous substrates and to undergo autophosphorylation.

Enzyme Numbers (IUBMB) for MOK Gene

Gene Ontology (GO) - Molecular Function for MOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10421840
GO:0004674 protein serine/threonine kinase activity IEA,TAS 10421840
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MOK: view
genes like me logo Genes that share phenotypes with MOK: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MOK Gene

Localization for MOK Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOK Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOK Gene COMPARTMENTS Subcellular localization image for MOK gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 3
golgi apparatus 2
nucleus 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for MOK Gene

Pathways & Interactions for MOK Gene

SuperPathways for MOK Gene

Superpath Contained pathways
1 IL-2 Pathway
genes like me logo Genes that share pathways with MOK: view

Pathways by source for MOK Gene

1 Qiagen pathway for MOK Gene

Gene Ontology (GO) - Biological Process for MOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10421840
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with MOK: view

No data available for SIGNOR curated interactions for MOK Gene

Drugs & Compounds for MOK Gene

(1) Drugs for MOK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MOK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MOK: view

Transcripts for MOK Gene

Unigene Clusters for MOK Gene

MOK protein kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5:
SP6: - - - - -
SP7: - - - -
SP8: - - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - - -
SP15: - - - - - - - - - - -
SP16: - - - -
SP17: - - - -
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26: - - -
SP27: - - - - - - - -
SP28: - - - -
SP29:
SP30:
SP31:
SP32:
SP33:
SP34:

ExUns: 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f ^ 17a · 17b ^ 18a · 18b · 18c · 18d ^ 19a · 19b ^ 20a · 20b ·
SP1: - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - - - - - - - - - - - - - - -
SP15: - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - - - - - - -
SP20: - - - - - - - - - - - - - - - -
SP21: - - - - - - - - - -
SP22: - - - - - - - - - - - - -
SP23: - - - - - - - - -
SP24: - - - - - - - - -
SP25: - - - - - - - - - - - - - - - - - - -
SP26:
SP27: - - - - - - - - - - - - - - - - - - - - - - - - -
SP28: - - - - - - - - - - - - - - - - - - - - - - -
SP29: - - - - - -
SP30: - - - -
SP31: - - - - - - -
SP32: - -
SP33:
SP34: - - - - - - - - - - -

ExUns: 20c · 20d · 20e · 20f · 20g · 20h ^ 21a · 21b · 21c · 21d · 21e · 21f ^ 22 ^ 23a · 23b · 23c ^ 24
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6:
SP7:
SP8:
SP9: - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - -
SP12:
SP13:
SP14: - - - -
SP15:
SP16: - - - - - - - - - - - - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22: - - - - - - - - - - - - -
SP23:
SP24:
SP25:
SP26:
SP27: - - - - - - - - - - - - -
SP28:
SP29:
SP30:
SP31:
SP32: - - - - - - - - - - - -
SP33:
SP34:

Relevant External Links for MOK Gene

GeneLoc Exon Structure for
MOK
ECgene alternative splicing isoforms for
MOK

Expression for MOK Gene

mRNA expression in normal human tissues for MOK Gene

mRNA differential expression in normal tissues according to GTEx for MOK Gene

This gene is overexpressed in Testis (x4.4).

SOURCE GeneReport for Unigene cluster for MOK Gene Hs.104119

mRNA Expression by UniProt/SwissProt for MOK Gene

Q9UQ07-MOK_HUMAN
Tissue specificity: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.
genes like me logo Genes that share expression patterns with MOK: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MOK Gene

Orthologs for MOK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAGE 35
  • 99.36 (n)
  • 99.28 (a)
MOK 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MOK 36
  • 73 (a)
OneToOne
MOK 35
  • 83.45 (n)
  • 82.08 (a)
dog
(Canis familiaris)
Mammalia MOK 36
  • 78 (a)
OneToOne
MOK 35
  • 87.5 (n)
  • 84.62 (a)
mouse
(Mus musculus)
Mammalia Mok 16
Stk30 36
  • 83 (a)
OneToOne
Stk30 35
  • 83.57 (n)
  • 83.73 (a)
oppossum
(Monodelphis domestica)
Mammalia MOK 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MOK 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mok 35
  • 91.13 (n)
  • 95.71 (a)
chicken
(Gallus gallus)
Aves MOK 36
  • 63 (a)
OneToOne
MOK 35
  • 68.75 (n)
  • 64.66 (a)
lizard
(Anolis carolinensis)
Reptilia MOK 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10381 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2425 35
mok 35
  • 67.53 (n)
  • 67.44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002515 35
  • 49.12 (n)
  • 38.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IME2 36
  • 18 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.27829 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToOne
Species with no ortholog for MOK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MOK Gene

ENSEMBL:
Gene Tree for MOK (if available)
TreeFam:
Gene Tree for MOK (if available)

Paralogs for MOK Gene

Paralogs for MOK Gene

genes like me logo Genes that share paralogs with MOK: view

Variants for MOK Gene

Sequence variations from dbSNP and Humsavar for MOK Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2236493 - 102,229,356(+) CCTTC(C/T)GCGGA intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime
rs34114580 - 102,283,487(+) CAAAG(C/G/T)GCTGC nc-transcript-variant, reference, missense
rs34084056 - 102,263,573(+) CATGT(C/T)CATAA nc-transcript-variant, reference, missense
rs34965156 - 102,233,691(+) ACTGT(C/T)TGAAC nc-transcript-variant, reference, missense
rs34299975 - 102,232,659(+) TAGAG(A/G)TATTC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MOK Gene

Variant ID Type Subtype PubMed ID
nsv1429 CNV Loss 18451855
esv22037 CNV Gain 19812545
esv2659155 CNV Deletion 23128226

Variation tolerance for MOK Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.38; 90.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOK Gene

HapMap Linkage Disequilibrium report
MOK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOK Gene

Disorders for MOK Gene

MalaCards: The human disease database

(2) MalaCards diseases for MOK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
kidney cancer
  • malignant neoplasm of kidney except pelvis
- elite association - COSMIC cancer census association via MalaCards
Search MOK in MalaCards View complete list of genes associated with diseases

Relevant External Links for MOK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOK
genes like me logo Genes that share disorders with MOK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOK Gene

Publications for MOK Gene

  1. Molecular cloning and characterization of a novel member of the MAP kinase superfamily. (PMID: 10421840) Miyata Y. … Nishida E. (Genes Cells 1999) 2 3 4 67
  2. Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma. (PMID: 17549666) Stav D. … Sandbank J. (Int. J. Biol. Markers 2007) 3 23
  3. Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells. (PMID: 15327990) Uesaka T. … Kageyama N. (FEBS Lett. 2004) 3 23
  4. mRNA expression of tumor-associated antigens in melanoma tissues and cell lines. (PMID: 12190937) EichmA1ller S. … Schadendorf D. (Exp. Dermatol. 2002) 3 23
  5. Tumor-associated antigens as possible targets for immune therapy in head and neck cancer: comparative mRNA expression analysis of RAGE and GAGE genes. (PMID: 12206267) GAPtte K. … EichmA1ller S. (Acta Otolaryngol. 2002) 3 23

Products for MOK Gene

Sources for MOK Gene

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