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MOK Gene

protein-coding   GIFtS: 51
GCID: GC14M102690

MOK Protein Kinase

(Previous name: renal tumor antigen)
(Previous symbol: RAGE)
  See MOK-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
MOK Protein Kinase1 2 3     Renal Tumor Antigen1
RAGE1 2 3 5     MAPK/MAK/MRK Overlapping Kinase2
Renal Tumor Antigen 12 3     Renal Cell Carcinoma Antigen2
RAGE-12 3     EC 2.7.11.223
RAGE12 3     

External Ids:    HGNC: 98331   Entrez Gene: 58912   Ensembl: ENSG000000808237   OMIM: 6057625   UniProtKB: Q9UQ073   
ORGUL members:         

Export aliases for MOK gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MOK Gene:
This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription
factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may
play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple
alternatively spliced transcript variants encoding different isoforms have been observed for this gene. (provided
by RefSeq, Dec 2012)

GeneCards Summary for MOK Gene:
MOK (MOK protein kinase) is a protein-coding gene. Diseases associated with MOK include renal cell carcinoma. GO annotations related to this gene include protein serine/threonine kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is MAK.

UniProtKB/Swiss-Prot: MOK_HUMAN, Q9UQ07
Function: Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (By similarity)

Gene Wiki entry for MOK (RAGE) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MOK
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MOK promoter sequence
   Search Chromatin IP Primers for MOK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MOK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32

MOK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOK gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M102690:  view genomic region     (about GC identifiers)

Start:
102,690,837 bp from pter      End:
102,771,537 bp from pter
Size:
80,701 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MOK_HUMAN, Q9UQ07 (See protein sequence)
Recommended Name: MAPK/MAK/MRK overlapping kinase  
Size: 419 amino acids; 48014 Da
Sequence caution: Sequence=AAB38087.1; Type=Frameshift; Positions=299;
Secondary accessions: Q92790 Q93067
Alternative splicing: 4 isoforms:  Q9UQ07-1   Q9UQ07-2   Q9UQ07-3   Q9UQ07-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MOK: NX_Q9UQ07

Explore proteomics data for MOK at MOPED

Post-translational modifications: 

  • Autophosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MOK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258940.1  NP_055041.1  

    ENSEMBL proteins: 
     ENSP00000453401   ENSP00000453449   ENSP00000453950   ENSP00000429348   ENSP00000453224  
     ENSP00000453762   ENSP00000452978   ENSP00000429469   ENSP00000355304   ENSP00000454098  
     ENSP00000429672   ENSP00000428942   ENSP00000430416   ENSP00000454203   ENSP00000453799  
     ENSP00000430775   ENSP00000454829   ENSP00000429570   ENSP00000429511   ENSP00000429428  
     ENSP00000428206   ENSP00000427884   ENSP00000428957   ENSP00000193029  

    MOK Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals MOK Proteins
    Novus Biologicals MOK Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MOK 

    MOK Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MOK
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    MOK Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MOK 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: MOK protein kinase
    RCK family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9UQ07

    ProtoNet protein and cluster: Q9UQ07

    UniProtKB/Swiss-Prot: MOK_HUMAN, Q9UQ07
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MOK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOK_HUMAN, Q9UQ07
    Function: Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Phosphorylation appears to increase the enzymatic activity (By similarity)

         Enzyme Number (IUBMB): EC 2.7.11.221

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10421840
    GO:0004674protein serine/threonine kinase activity TAS10421840
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with MOK           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for MOK:
     Decreased cilium length after   Decreased focal adhesion (FA)   Synthetic lethal with paclitax 

         1 MGI phenotypic allele for Stk30 (no phenotypes)

    Find genes that share phenotypes with MOK           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MOK
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MOK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MOK

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MOK

    Gene Editing
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    Sino Biological Human cDNA Clone for MOK
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOK
    Addgene plasmids for MOK 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MOK_HUMAN, Q9UQ07: Cytoplasm (By similarity)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with MOK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MOK
        HMGB1 Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MOK
    Interactions:

        Search GeneGlobe Interaction Network for MOK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MOK (Q9UQ072, 3 ENSP000003553044) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8261824 I2D: score=2 
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    MYCP011063, ENSP000003672074I2D: score=2 STRING: ENSP00000367207
    S100PP258153, ENSP000002963704I2D: score=1 STRING: ENSP00000296370
    CCNB1P146353, ENSP000002564424I2D: score=2 STRING: ENSP00000256442
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS10421840
    GO:0007165signal transduction TAS10421840

    Find genes that share ontologies with MOK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MOK



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MOK gene (2 alternative transcripts): 
    NM_001272011.1  NM_014226.2  

    Unigene Cluster for MOK:

    MOK protein kinase
    Hs.104119  [show with all ESTs]
    Unigene Representative Sequence: NR_073540
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 41):
    ENST00000559512 ENST00000559138(uc001ylh.3) ENST00000559838 ENST00000557823
    ENST00000561150 ENST00000521249 ENST00000521766 ENST00000517966(uc001ylj.3)
    ENST00000523485 ENST00000519569(uc001yln.3) ENST00000523231 ENST00000524370(uc001ylk.3 uc001yll.3)
    ENST00000522874 ENST00000518686 ENST00000361847(uc001ylm.3 uc010txv.2)
    ENST00000522867 ENST00000520266 ENST00000519058
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MOK using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MOK
    SwitchGear 3'UTR luciferase reporter plasmidMOK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MOK
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MOK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOK
    Addgene plasmids for MOK 
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      QuantiTect SYBR Green Assays in human, mouse, rat MOK
      QuantiFast Probe-based Assays in human, mouse, rat MOK

    Additional mRNA sequence: 

    AB022694.1 AK302349.1 AK312778.1 NR_073540.1 NR_073541.1 NR_073542.1 NR_073543.1 U46191.1 
    U46192.1 U46193.1 U46194.1 

    Selected DOTS entries (see all 43):

    DT.214754  DT.214751  DT.100874857  DT.97848384  DT.100874854  DT.95136679  DT.95147163  DT.100874843 
    DT.100874849  DT.92428680  DT.95137604  DT.100874855  DT.92428666  DT.92428682  DT.95232244  DT.100874859 
    DT.92428674  DT.92428677  DT.92428681  DT.100029026  DT.100874848  DT.100874862  DT.120782321  DT.100029021 

    Selected AceView cDNA sequences (see all 218):

    AI745403 AI208165 BM856848 CB126651 BM854235 BM854244 CB148478 AA382408 
    BE385929 CB136859 BP371213 AB022694 AI200094 BM857292 BQ009254 CR592213 
    AW439064 CB126380 BM453870 BQ083058 CB126269 BI259017 CA440903 BC026069 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MOK (see all 34)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^
    SP1:                                            -                                   -     -                 -     -     -     -     -     -     -     -     -   
    SP2:                                            -                                                           -     -     -     -     -     -     -     -     -   
    SP3:                                            -                                   -     -                 -     -     -     -     -     -     -     -     -   
    SP4:                                            -     -     -                       -     -                 -     -     -     -     -     -     -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f ^ 17a · 17b ^ 18a · 18b · 18c · 18d ^ 19a · 19b ^ 20a · 20b ·
    SP1:  -     -     -     -     -     -     -     -     -     -     -           -     -     -     -     -     -                                                   
    SP2:  -     -     -     -     -     -     -     -     -     -     -           -     -     -     -     -     -                                                   
    SP3:  -     -     -     -     -     -     -     -     -     -     -                                                                                             
    SP4:  -     -     -     -     -     -     -     -     -     -     -                                                                                             
    SP5:  -     -           -     -     -     -     -     -     -     -           -     -     -     -     -     -                             -     -               

    ExUns: 20c · 20d · 20e · 20f · 20g · 20h ^ 21a · 21b · 21c · 21d · 21e · 21f ^ 22 ^ 23a · 23b · 23c ^ 24
    SP1:              -     -     -     -                                                                     
    SP2:              -     -     -     -                                                                     
    SP3:              -     -     -     -                                                                     
    SP4:              -     -     -     -                                                                     
    SP5:              -     -     -     -                                                                     


    ECgene alternative splicing isoforms for MOK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MOK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTACCAGT
    MOK Expression
    About this image

    MOK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MOK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.104119

    UniProtKB/Swiss-Prot: MOK_HUMAN, Q9UQ07
    Tissue specificity: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta,
    liver and skeletal muscle. Detected in retina

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MOK gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk301 , 5 serine/threonine kinase 301, 5 83.57(n)1
    83.73(a)1
      12 (60.81 cM)5
    264481  NM_011973.21  NP_036103.11 
     1108077985 
    chicken
    (Gallus gallus)
    Aves MOK1 MOK protein kinase 68.75(n)
    64.66(a)
      428910  XM_004936326.1  XP_004936383.1 
    lizard
    (Anolis carolinensis)
    Reptilia MOK6
    MOK protein kinase
    62(a)
    1 ↔ 1
    GL343232.1(1812223-1826315)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.103812 Xenopus laevis transcribed sequence with moderate similarity more 76.49(n)    CB592375.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0025151 AgaP_AGAP002515 49.12(n)
    38.95(a)
      1273447  XM_312423.5  XP_312423.5 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IME26
    Serine/threonine protein kinase involved in activa...
    18(a)
    1 → many
    X(221390-223327) YJL106W
    wheat
    (Triticum aestivum)
    Liliopsida Ta.278292 Triticum aestivum transcribed sequence with weak similarity more 74.41(n)    CD867230.1 


    ENSEMBL Gene Tree for MOK (if available)
    TreeFam Gene Tree for MOK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MOK gene
    MAK2  ICK2  
    Selected SIMAP similar genes for MOK using alignment to 13 protein entries:     MOK_HUMAN (see all proteins) (see all similar genes):
    RAGE    MAPK8    MAPK4    NEK9    CDK7    DKFZp564L2416
    DYRK1A    MAK    NLK    FGFR1    CCRK    CDK16
    CDK17    ICK    MAPK1    MAPK14    BRAF    CDK3

    Find genes that share paralogs with MOK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MOK (see all 1751)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0420154
    A breast pleomorphic lobular carcinoma sample4--see VAR_0420152 E D mis40--------
    rs1903989041,2
    --82886430(+) TTCTGA/GGTCTC 4 -- us2k10--------
    rs1399071841,2
    C--82886466(+) TGCACC/GCTTCA 4 -- us2k10--------
    rs1452908451,2
    C--82886606(+) TCATCC/TGTTAC 4 -- us2k10--------
    rs1826994981,2
    --82886936(+) TGCAGA/GGCTGT 4 -- us2k10--------
    rs1476534221,2
    --82886967(+) AGAGCC/TGGGAC 4 -- us2k10--------
    rs1404553871,2
    --82886968(+) GAGCCA/GGGACC 4 -- us2k10--------
    rs1497217311,2
    C--82887042(+) CTGTGC/TGGCAG 4 -- us2k10--------
    rs1149217271,2
    C,F--82887053(+) CTGCCG/ATCACC 4 -- us2k12Minor allele frequency- A:0.06WA NA 238
    rs1454941561,2
    C--82887187(+) CTTCAC/GCTGTA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for MOK (102690837 - 102771537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MOK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659155CNV Deletion23128226
    nsv1429CNV Loss18451855
    esv22037CNV Gain19812545

    Human Gene Mutation Database (HGMD): MOK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MOK
    DNA2.0 Custom Variant and Variant Library Synthesis for MOK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605762    OMIM disorders: --

    1 disease for MOK:    
    About MalaCards
    renal cell carcinoma


    Find genes that share disorders with MOK           About GenesLikeMe

    3 Novoseek inferred disease relationships for MOK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 46.9 1 9865739 (1)
    tumors 22.8 8 8056452 (1), 10037196 (1), 12206267 (1), 9865739 (1) (see all 6)
    cancer 0 1 10741395 (1)


    Export disorders for MOK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MOK gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with MOK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel member of the MAP kinase superfamily. (PubMed id 10421840)1, 2, 3 Miyata Y.... Nishida E. (Genes Cells 1999)
    2. A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma. (PubMed id 8781117)1, 2, 3 Gaugler B....Van den Eynde B.J. (Immunogenetics 1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells. (PubMed id 15327990)1, 9 Uesaka T. and Kageyama N. (FEBS Lett. 2004)
    5. Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma. (PubMed id 17549666)1, 9 Stav D....Sandbank J. (Int. J. Biol. Markers 2007)
    6. Tumor-associated antigens as possible targets for immune therapy in head and neck cancer: comparative mRNA expression analysis of RAGE and GAGE genes. (PubMed id 12206267)1, 9 GAPtte K....EichmA1ller S. (Acta Otolaryngol. 2002)
    7. mRNA expression of tumor-associated antigens in melanoma tissues and cell lines. (PubMed id 12190937)1, 9 EichmA1ller S....Schadendorf D. (Exp. Dermatol. 2002)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Overexpression of renal tumor antigen is associated with tumor invasion and poor prognosis of hepatocellular carcinoma. (PubMed id 21717246)1 Cha H.J....Choi K.Y. (Ann. Surg. Oncol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5891 HGNC: 9833 AceView: RAGE Ensembl:ENSG00000080823 euGenes: HUgn5891
    ECgene: MOK H-InvDB: MOK

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MOK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MOK gene:
    Search GeneIP for patents involving MOK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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