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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MOK Gene

protein-coding   GIFtS: 52
GCID: GC14M102690

MOK Protein Kinase

(Previous name: renal tumor antigen)
(Previous symbol: RAGE)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MOK Protein Kinase1 2 3     Renal Tumor Antigen1
RAGE1 2 3 5     MAPK/MAK/MRK Overlapping Kinase2
Renal Tumor Antigen 12 3     Renal Cell Carcinoma Antigen2
RAGE-12 3     EC 2.7.11.223
RAGE12 3     

External Ids:    HGNC: 98331   Entrez Gene: 58912   Ensembl: ENSG000000808237   OMIM: 6057625   UniProtKB: Q9UQ073   

Export aliases for MOK gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MOK Gene:
This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription
factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may
play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple
alternatively spliced transcript variants encoding different isoforms have been observed for this gene. (provided
by RefSeq, Dec 2012)

GeneCards Summary for MOK Gene: 
MOK (MOK protein kinase) is a protein-coding gene. Diseases associated with MOK include renal cell carcinoma, and kidney cancer. GO annotations related to this gene include protein serine/threonine kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is MAK.

UniProtKB/Swiss-Prot: MOK_HUMAN, Q9UQ07
Function: Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (By similarity)

Gene Wiki entry for MOK (RAGE) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MOK
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MOK promoter sequence
   Search SABiosciences Chromatin IP Primers for MOK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32

MOK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOK gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M102690:  view genomic region     (about GC identifiers)

Start:
102,690,837 bp from pter      End:
102,771,537 bp from pter
Size:
80,701 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MOK_HUMAN, Q9UQ07 (See protein sequence)
Recommended Name: MAPK/MAK/MRK overlapping kinase  
Size: 419 amino acids; 48014 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAB38087.1; Type=Frameshift; Positions=299;
Secondary accessions: Q92790 Q93067
Alternative splicing: 4 isoforms:  Q9UQ07-1   Q9UQ07-2   Q9UQ07-3   Q9UQ07-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MOK: NX_Q9UQ07

Explore proteomics data for MOK at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UQ07

  • MOK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MOK Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001258940.1  NP_055041.1  

    ENSEMBL proteins: 
     ENSP00000453401   ENSP00000453449   ENSP00000453950   ENSP00000429348   ENSP00000453224  
     ENSP00000453762   ENSP00000452978   ENSP00000429469   ENSP00000355304   ENSP00000454098  
     ENSP00000429672   ENSP00000428942   ENSP00000430416   ENSP00000454203   ENSP00000453799  
     ENSP00000430775   ENSP00000454829   ENSP00000429570   ENSP00000429511   ENSP00000429428  
     ENSP00000428206   ENSP00000427884   ENSP00000428957   ENSP00000193029  

    Human Recombinant Protein Products for MOK: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for MOK
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    Novus Biologicals MOK Proteins
    Novus Biologicals MOK Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    MOK for ontologies           About GeneDecksing



    MOK Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: MOK protein kinase 
    RCK family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9UQ07

    ProtoNet protein and cluster: Q9UQ07

    UniProtKB/Swiss-Prot: MOK_HUMAN, Q9UQ07
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    MOK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOK_HUMAN, Q9UQ07
    Function: Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Phosphorylation appears to increase the enzymatic activity (By similarity)

         Enzyme Number (IUBMB): EC 2.7.11.221

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10421840
    GO:0004674protein serine/threonine kinase activity TAS10421840
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    MOK for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MOK:
     Decreased cilium length after   Decreased focal adhesion (FA)   Synthetic lethal with paclitax 

         1 MGI phenotypic allele for Stk30 (no phenotypes)

    MOK for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MOK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MOK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MOK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MOK 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOK
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MOK
    SwitchGear 3'UTR luciferase reporter plasmidMOK 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MOK

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for MOK (Q9UQ072, 3 ENSP000003553044) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8261824 I2D: score=2 
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    MYCP011063, ENSP000003672074I2D: score=2 STRING: ENSP00000367207
    S100PP258153, ENSP000002963704I2D: score=1 STRING: ENSP00000296370
    CCNB1P146353, ENSP000002564424I2D: score=2 STRING: ENSP00000256442
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS10421840
    GO:0007165signal transduction TAS10421840

    MOK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MOK

    Search CenterWatch for drugs/clinical trials and news about MOK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MOK gene (2 alternative transcripts): 
    NM_001272011.1  NM_014226.2  

    Unigene Cluster for MOK:

    MOK protein kinase
    Hs.104119  [show with all ESTs]
    Unigene Representative Sequence: NR_073540
    18/41 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 41):
    ENST00000559512 ENST00000559138(uc001ylh.3) ENST00000559838 ENST00000557823
    ENST00000561150 ENST00000521249 ENST00000521766 ENST00000517966(uc001ylj.3)
    ENST00000523485 ENST00000519569(uc001yln.3) ENST00000523231 ENST00000524370(uc001ylk.3 uc001yll.3)
    ENST00000522874 ENST00000518686 ENST00000361847(uc001ylm.3 uc010txv.2)
    ENST00000522867 ENST00000520266 ENST00000519058
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOK
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MOK
    SwitchGear 3'UTR luciferase reporter plasmidMOK 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MOK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOK
    Clone
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    OriGene ORF clones in mouse, rat for MOK
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOK
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    Sirion Biotech Customized lentivirus for stable overexpression of MOK 
                         Customized lentivirus expression plasmids for stable overexpression of MOK 
    Primer
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    OriGene qPCR primer pairs and template standards for MOK
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOK

    Additional mRNA sequence: 

    AB022694.1 AK302349.1 AK312778.1 NR_073540.1 NR_073541.1 NR_073542.1 NR_073543.1 U46191.1 
    U46192.1 U46193.1 U46194.1 

    24/43 DOTS entries (see all 43):

    DT.214754  DT.214751  DT.100874857  DT.97848384  DT.100874854  DT.95136679  DT.95147163  DT.100874843 
    DT.100874849  DT.92428680  DT.95137604  DT.100874855  DT.92428666  DT.92428682  DT.95232244  DT.100874859 
    DT.92428674  DT.92428677  DT.92428681  DT.100029026  DT.100874848  DT.100874862  DT.120782321  DT.100029021 

    24/218 AceView cDNA sequences (see all 218):

    CA427336 NM_014226 CB111659 BM853786 BI762914 CN484088 U46193 BM554085 
    BE548321 BG110433 BC053536 BI259017 CB141683 AI026766 AI208165 BC026069 
    BM856848 CA440903 U46191 CB126380 CB124917 CA430276 BM717539 AK131542 

    GeneLoc Exon Structure

    5/34 Alternative Splicing Database (ASD) splice patterns (SP) for MOK (see all 34)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^
    SP1:                                            -                                   -     -                 -     -     -     -     -     -     -     -     -   
    SP2:                                            -                                                           -     -     -     -     -     -     -     -     -   
    SP3:                                            -                                   -     -                 -     -     -     -     -     -     -     -     -   
    SP4:                                            -     -     -                       -     -                 -     -     -     -     -     -     -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f ^ 17a · 17b ^ 18a · 18b · 18c · 18d ^ 19a · 19b ^ 20a · 20b ·
    SP1:  -     -     -     -     -     -     -     -     -     -     -           -     -     -     -     -     -                                                   
    SP2:  -     -     -     -     -     -     -     -     -     -     -           -     -     -     -     -     -                                                   
    SP3:  -     -     -     -     -     -     -     -     -     -     -                                                                                             
    SP4:  -     -     -     -     -     -     -     -     -     -     -                                                                                             
    SP5:  -     -           -     -     -     -     -     -     -     -           -     -     -     -     -     -                             -     -               

    ExUns: 20c · 20d · 20e · 20f · 20g · 20h ^ 21a · 21b · 21c · 21d · 21e · 21f ^ 22 ^ 23a · 23b · 23c ^ 24
    SP1:              -     -     -     -                                                                     
    SP2:              -     -     -     -                                                                     
    SP3:              -     -     -     -                                                                     
    SP4:              -     -     -     -                                                                     
    SP5:              -     -     -     -                                                                     


    ECgene alternative splicing isoforms for MOK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MOK expression in normal human tissues (normalized intensities)      MOK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTACCAGT
    MOK Expression
    About this image


    MOK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)
             Human Skeletal Muscle Myoblast (HSkMM)   
     
     Fibroblast (Endocrine System)
             Human Prostate Fibroblasts (HPrF)   
     
     Epithelium (Respiratory System)
             bronchial epithelia   
     
     Prostate (Endocrine System)
             Human Prostate Fibroblasts (HPrF)   
     
     Uncategorized (Uncategorized)
             PureStem Progenitor ES-198

    See MOK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MOK

    SOURCE GeneReport for Unigene cluster: Hs.104119

    UniProtKB/Swiss-Prot: MOK_HUMAN, Q9UQ07
    Tissue specificity: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta,
    liver and skeletal muscle. Detected in retina

        SABiosciences Custom PCR Arrays for MOK
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MOK gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Stk301 , 5 serine/threonine kinase 301, 5 83.57(n)1
    83.73(a)1
      12 (60.81 cM)5
    264481  NM_011973.21  NP_036103.11 
     1108077985 
    chicken
    (Gallus gallus)
    Aves RAGE1 renal tumor antigen 76.05(n)
    76.82(a)
      428910  XM_426466.3  XP_426466.3 
    lizard
    (Anolis carolinensis)
    Reptilia MOK6
    MOK protein kinase
    64(a)
    1 ↔ 1
    GL343232.1(1812223-1826315)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.103812 Xenopus laevis transcribed sequence with moderate similarity more 76.49(n)    CB592375.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0025151 AGAP002515-PA 49.29(n)
    39.36(a)
      1273447  XM_312423.4  XP_312423.4 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IME26
    Serine/threonine protein kinase involved in activa...
    17(a)
    1 → many
    X(221390-223327)
    wheat
    (Triticum aestivum)
    Liliopsida Ta.278292 Triticum aestivum transcribed sequence with weak similarity more 74.41(n)    CD867230.1 


    ENSEMBL Gene Tree for MOK (if available)
    TreeFam Gene Tree for MOK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MOK gene
    MAK2  ICK2  
    18/63 SIMAP similar genes for MOK using alignment to 13 protein entries:     MOK_HUMAN (see all proteins) (see all similar genes):
    RAGE    MAPK8    MAPK4    NEK9    CDK7    DKFZp564L2416
    DYRK1A    MAK    NLK    FGFR1    CCRK    CDK16
    CDK17    ICK    MAPK1    MAPK14    BRAF    CDK3

    MOK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1751 SNPs in MOK are shown (see all 1751)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0420154
    A breast pleomorphic lobular carcinoma sample4--see VAR_0420152 E D mis40--------
    rs1903989041,2
    --82886430(+) TTCTGA/GGTCTC 4 -- us2k10--------
    rs1399071841,2
    C--82886466(+) TGCACC/GCTTCA 4 -- us2k10--------
    rs1452908451,2
    C--82886606(+) TCATCC/TGTTAC 4 -- us2k10--------
    rs1826994981,2
    --82886936(+) TGCAGA/GGCTGT 4 -- us2k10--------
    rs1476534221,2
    --82886967(+) AGAGCC/TGGGAC 4 -- us2k10--------
    rs1404553871,2
    --82886968(+) GAGCCA/GGGACC 4 -- us2k10--------
    rs1497217311,2
    C--82887042(+) CTGTGC/TGGCAG 4 -- us2k10--------
    rs1149217271,2
    C,F--82887053(+) CTGCCG/ATCACC 4 -- us2k12Minor allele frequency- A:0.06WA NA 238
    rs1454941561,2
    C--82887187(+) CTTCAC/GCTGTA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for MOK (102690837 - 102771537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MOK:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2659155CNV Deletion23128226
    nsv1429CNV Loss18451855
    esv22037CNV Gain19812545


    Human Gene Mutation Database (HGMD): MOK
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MOK
    DNA2.0 Custom Variant and Variant Library Synthesis for MOK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605762    OMIM disorders: --

    9 diseases for MOK:    About MalaCards
    renal cell carcinoma    kidney cancer    clear cell renal cell carcinoma    lung adenocarcinoma
    myeloma    thyroiditis    adenocarcinoma    melanoma
    hepatocellular carcinoma


    MOK for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for MOK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 46.9 1 9865739 (1)
    tumors 22.8 8 8056452 (1), 10037196 (1), 12206267 (1), 9865739 (1) (see all 6)
    cancer 0 1 10741395 (1)


    Export disorders for MOK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MOK gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with MOK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel member of the MAP kinase superfamily. (PubMed id 10421840)1, 2, 3 Miyata Y.... Nishida E. (1999)
    2. A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma. (PubMed id 8781117)1, 2, 3 Gaugler B....Van den Eynde B.J. (1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells. (PubMed id 15327990)1, 9 Uesaka T. and Kageyama N. (2004)
    5. Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma. (PubMed id 17549666)1, 9 Stav D....Sandbank J. (2007)
    6. Tumor-associated antigens as possible targets for immune therapy in head and neck cancer: comparative mRNA expression analysis of RAGE and GAGE genes. (PubMed id 12206267)1, 9 Gotte K....Eichmuller S. (2002)
    7. mRNA expression of tumor-associated antigens in melanoma tissues and cell lines. (PubMed id 12190937)1, 9 Eichmuller S....Schadendorf D. (2002)
    8. Overexpression of renal tumor antigen is associated wi th tumor invasion and poor prognosis of hepatocellular carcinoma. (PubMed id 21717246)1 Cha H.J....Choi K.Y. (2012)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. S100B attenuates microglia activation in gliomas: pos sible role of STAT3 pathway. (PubMed id 21264954)1 Zhang L....Badie B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5891 HGNC: 9833 AceView: RAGE Ensembl:ENSG00000080823 euGenes: HUgn5891
    ECgene: MOK H-InvDB: MOK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MOK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MOK gene:
    Search GeneIP for patents involving MOK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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