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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MOK Gene

protein-coding   GIFtS: 52
GCID: GC14M102690

MOK protein kinase

(Previous name: renal tumor antigen )
(Previous symbol: RAGE)
 Explore 14 diseases affiliated with
MOK via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MOK    

Aliases
for MOK gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
MOK Protein Kinase1 2 3     Renal Tumor Antigen1
RAGE1 2 3 5     MAPK/MAK/MRK Overlapping Kinase2
RAGE11 2 3     Renal Cell Carcinoma Antigen2
Renal Tumor Antigen 12 3     EC 2.7.11.223
RAGE-12 3     

External Ids:    HGNC: 98331   Entrez Gene: 58912   Ensembl: ENSG000000808237   OMIM: 6057625   UniProtKB: Q9UQ073   

Export aliases for MOK gene to outside databases


Summaries
for MOK gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MOK:
This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor
2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role
in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced
transcript variants encoding different isoforms have been observed for this gene. (provided by RefSeq, Dec 2012)

UniProtKB/Swiss-Prot: MOK_HUMAN, Q9UQ07
Function: Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (By similarity)

Gene Wiki entry for MOK (RAGE)


Genomic Views
for MOK gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MOK
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MOK promoter sequence
   Search SABiosciences Chromatin IP Primers for MOK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32

MOK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOK gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M102690:  view genomic region     (about GC identifiers)

Start:
 102,690,837 bp from pter      End:
 102,771,537 bp from pter
Size:
 80,701 bases      Orientation:
 minus strand

Proteins
for MOK gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MOK_HUMAN, Q9UQ07 (See protein sequence)
Recommended Name: MAPK/MAK/MRK overlapping kinase  
Size: 419 amino acids; 48014 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAB38087.1; Type=Frameshift; Positions=299;
Secondary accessions: Q92790 Q93067
Alternative splicing: 4 isoforms:  Q9UQ07-1   Q9UQ07-2   Q9UQ07-3   Q9UQ07-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MOK: NX_Q9UQ07

Post-translational modifications:

  • Autophosphorylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UQ07

    • MOK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258940.1  NP_055041.1  

    ENSEMBL proteins: 
     ENSP00000453401   ENSP00000453449   ENSP00000453950   ENSP00000429348   ENSP00000453224  
     ENSP00000453762   ENSP00000452978   ENSP00000429469   ENSP00000355304   ENSP00000454098  
     ENSP00000429672   ENSP00000428942   ENSP00000430416   ENSP00000454203   ENSP00000453799  
     ENSP00000430775   ENSP00000454829   ENSP00000429570   ENSP00000429511   ENSP00000429428  
     ENSP00000428206   ENSP00000427884   ENSP00000428957   ENSP00000193029  

    Human Recombinant Protein Products: 
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    Uscn Proteins for MOK

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--


    MOK for ontologies           About GeneDecksing



    MOK Antibody Products: 
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    Uscn ELISAs and CLIAs for MOK

    Protein Domains /
    Families
    for MOK gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MOK for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9UQ07

    ProtoNet protein and cluster: Q9UQ07

    UniProtKB/Swiss-Prot: MOK_HUMAN, Q9UQ07
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MOK gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MOK_HUMAN, Q9UQ07
    Function: Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Phosphorylation appears to increase the enzymatic activity (By similarity)

    Enzyme Number (IUBMB): EC 2.7.11.221

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOK
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MOK
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for MOK

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10421840
    GO:0004674protein serine/threonine kinase activity TAS10421840
    GO:0004693cyclin-dependent protein kinase activity IEA--
    GO:0005524ATP binding IEA--


    MOK for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for MOK:
     Decreased cilium length after   Decreased focal adhesion (FA)   Synthetic lethal with paclitax 

    Animal Models:
         1 MGI phenotypic allele for Stk30 (no phenotypes)

    MOK for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MOK gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for MOK (Q9UQ072, 3 ENSP000003553044) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8261824 I2D: score=2 
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    MYCP011063, ENSP000003672074I2D: score=2 STRING: ENSP00000367207
    S100PP258153, ENSP000002963704I2D: score=1 STRING: ENSP00000296370
    CCNB1P146353, ENSP000002564424I2D: score=2 STRING: ENSP00000256442
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS10421840
    GO:0007165signal transduction TAS10421840


    MOK for ontologies           About GeneDecksing



    Drugs & Compounds
    for MOK gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MOK
    Search CenterWatch for drugs/clinical trials and news about MOK 

    Transcripts
    for MOK gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MOK gene (2 alternative transcripts): 
    NM_001272011.1  NM_014226.2  

    Unigene Cluster for MOK:

    MOK protein kinase
    Hs.104119  [show with all ESTs]
    Unigene Representative Sequence: U46194
    18/42 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 42):
    ENST00000559512 ENST00000559138(uc001ylh.3) ENST00000559838 ENST00000557823
    ENST00000561150 ENST00000521249 ENST00000521766 ENST00000517966(uc001ylj.3)
    ENST00000523485 ENST00000519569(uc001yln.3) ENST00000523231 ENST00000524370(uc001ylk.3 uc001yll.3)
    ENST00000522874 ENST00000518686 ENST00000361847(uc001ylm.3 uc010txv.2)
    ENST00000522867 ENST00000520266 ENST00000519058

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOK
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    Inhib. RNA
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOK

    Additional cDNA sequence: 

    AB022694.1 AK302349.1 AK312778.1 U46191.1 U46192.1 U46193.1 U46194.1 

    24/43 DOTS entries (see all 43):

    DT.214754  DT.214751  DT.100874857  DT.97848384  DT.100874854  DT.95136679  DT.95147163  DT.100874843 
    DT.100874849  DT.92428680  DT.95137604  DT.100874855  DT.92428666  DT.92428682  DT.95232244  DT.100874859 
    DT.92428674  DT.92428677  DT.92428681  DT.100029026  DT.100874848  DT.100874862  DT.120782321  DT.100029021 

    24/218 AceView cDNA sequences (see all 218):

    BM857292 CN484088 BM915381 BM971562 U46192 AW439064 BQ083058 BG110433 
    BM717539 BM853786 BM822914 BC053536 U46191 CB124721 U46194 AK131542 
    CA430276 BI826453 BM830160 CB140901 CA440903 AI026766 CB126651 CB124917 

    GeneLoc Exon Structure

    5/34 Alternative Splicing Database (ASD) splice patterns (SP) for MOK (see all 34)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^
    SP1:                                            -                                   -     -                 -     -     -     -     -     -     -     -     -   
    SP2:                                            -                                                           -     -     -     -     -     -     -     -     -   
    SP3:                                            -                                   -     -                 -     -     -     -     -     -     -     -     -   
    SP4:                                            -     -     -                       -     -                 -     -     -     -     -     -     -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f ^ 17a · 17b ^ 18a · 18b · 18c · 18d ^ 19a · 19b ^ 20a · 20b ·
    SP1:  -     -     -     -     -     -     -     -     -     -     -           -     -     -     -     -     -                                                   
    SP2:  -     -     -     -     -     -     -     -     -     -     -           -     -     -     -     -     -                                                   
    SP3:  -     -     -     -     -     -     -     -     -     -     -                                                                                             
    SP4:  -     -     -     -     -     -     -     -     -     -     -                                                                                             
    SP5:  -     -           -     -     -     -     -     -     -     -           -     -     -     -     -     -                             -     -               

    ExUns: 20c · 20d · 20e · 20f · 20g · 20h ^ 21a · 21b · 21c · 21d · 21e · 21f ^ 22 ^ 23a · 23b · 23c ^ 24
    SP1:              -     -     -     -                                                                     
    SP2:              -     -     -     -                                                                     
    SP3:              -     -     -     -                                                                     
    SP4:              -     -     -     -                                                                     
    SP5:              -     -     -     -                                                                     


    ECgene alternative splicing isoforms for MOK

    Expression
    for MOK gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MOK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTTACCAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MOK expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MOK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MOK

    SOURCE GeneReport for Unigene cluster: Hs.104119

    UniProtKB/Swiss-Prot: MOK_HUMAN, Q9UQ07
    Tissue specificity: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver
    and skeletal muscle. Detected in retina

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    In Situ
    Assay Products:     
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    Orthologs
    for MOK gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MOK gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RAGE1 renal tumor antigen 76.05(n)
    76.82(a)    		   428910  XM_426466.3  XP_426466.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MOK6
    		 --
    		 64(a)
    		 1 ↔ 1
    		 GL343232.1(1814966-1825604)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.103812 Xenopus laevis transcribed sequence with moderate similarity more 76.49(n)    CB592375.1 
    mosquito
    (Anopheles gambiae)    		 Insecta AgaP_AGAP0025151 AGAP002515-PA 49.29(n)
    39.36(a)    		   1273447  XM_312423.4  XP_312423.4 
    wheat
    (Triticum aestivum)    		 Liliopsida Ta.278292 Triticum aestivum transcribed sequence with weak similarity more 74.41(n)    CD867230.1 


    ENSEMBL Gene Tree for MOK (if available)
    TreeFam Gene Tree for MOK (if available) 

    Paralogs
    for MOK gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MOK gene
    CDKL12  CDKL22  CDKL52  CDKL32  MAK2  CDKL42  ICK2  
    18/63 SIMAP similar genes for MOK using alignment to 13 protein entries:     MOK_HUMAN (see all proteins) (see all similar genes):
    RAGE    MAPK8    MAPK4    NEK9    CDK7    DKFZp564L2416
    DYRK1A    MAK    NLK    FGFR1    CCRK    CDK16
    CDK17    ICK    MAPK1    MAPK14    BRAF    CDK3

    MOK for paralogs           About GeneDecksing



    Genomic Variants
    for MOK gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1388 NCBI SNPs in MOK are shown (see all 1388)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1864709861,2
    		--102694693(+) CCGAGA/GACACG 1 -- int10--------
    rs1176347961,2
    		--102694823(+) GAAGTC/GGGGAG 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1405530571,2
    		--102694893(+) TCAGCC/TGGGCG 1 -- int10--------
    rs1115175201,2
    		--102694909(+) GTGCAT/CGCACG 1 -- int13Minor allele frequency- C:0.09CSA WA EA 240
    rs1475643121,2
    		--102694917(+) CGTAA-/TTCCCA 1 -- int10--------
    rs1913621011,2
    		--102694997(+) CGCCAC/TTGCAC 1 -- int10--------
    rs1154423971,2
    		F,--102695007(+) CTCCAA/TCCTGG 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1160115691,2
    		F,--102695020(+) AATGAA/GCGAAA 1 -- int11Minor allele frequency- G:0.03WA 118
    rs118472791,2
    		C,H,--102695178(+) TACTGT/CAACGA 1 -- ut312Minor allele frequency- C:0.11NA WA 120
    rs1455559851,2
    		--102695200(+) TTAATA/GAAAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MOK (102690837 - 102771537 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MOK: --
    Human Gene Mutation Database (HGMD): MOK

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MOK
    DNA2.0 Custom Variant and Variant Library Synthesis for MOK

    Disorders / Diseases
    for MOK gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MOK for disorders           About GeneDecksing

    OMIM gene information: 605762    OMIM disorders: --

    14 diseases for MOK:    About MalaCards
    renal cell carcinoma    clear cell renal cell carcinoma    carcinoma    embryonal carcinoma
    nephropathy    kidney cancer    lung adenocarcinoma    renal carcinoma
    thyroid carcinoma    thyroiditis    adenocarcinoma    myeloma
    melanoma    malaria

    3 Novoseek disease relationships for MOK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 46.9 1 9865739 (1)
    tumors 22.8 8 8056452 (1), 10037196 (1), 12206267 (1), 9865739 (1) (see all 6)
    cancer 0 1 10741395 (1)


    Export disorders for MOK gene to outside databases

    Publications
    for MOK gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MOK gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with MOK)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel member of the MAP kinase superfamily. (PubMed id 10421840)1, 2, 3 Miyata Y.... Nishida E. (1999)
    2. A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma. (PubMed id 8781117)1, 2, 3 Gaugler B....Van den Eynde B.J. (1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells. (PubMed id 15327990)1, 9 Uesaka T. and Kageyama N. (2004)
    5. Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma. (PubMed id 17549666)1, 9 Stav D....Sandbank J. (2007)
    6. Tumor-associated antigens as possible targets for immune therapy in head and neck cancer: comparative mRNA expression analysis of RAGE and GAGE genes. (PubMed id 12206267)1, 9 Gotte K....Eichmuller S. (2002)
    7. mRNA expression of tumor-associated antigens in melanoma tissues and cell lines. (PubMed id 12190937)1, 9 Eichmuller S....Schadendorf D. (2002)
    8. Overexpression of renal tumor antigen is associated wi th tumor invasion and poor prognosis of hepatocellular carcinoma. (PubMed id 21717246)1 Cha H.J....Choi K.Y. (2012)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. S100B attenuates microglia activation in gliomas: pos sible role of STAT3 pathway. (PubMed id 21264954)1 Zhang L....Badie B. (2011)

    External Searches for MOK gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MOK gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5891 HGNC: 9833 AceView: RAGE Ensembl:ENSG00000080823 euGenes: HUgn5891
    ECgene: MOK H-InvDB: MOK

    Other Databases showing MOK gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MOK gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MOK Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MOK gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MOK gene:
    Search GeneIP for patents involving MOK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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