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Aliases for MOK Gene

Aliases for MOK Gene

  • MOK Protein Kinase 2 3 4
  • Renal Tumor Antigen 1 3 4
  • RAGE-1 3 4
  • RAGE1 3 4
  • RAGE 3 4
  • Renal Cell Carcinoma Antigen 3
  • Renal Tumor Antigen 2
  • EC 2.7.11.22 4
  • STK30 3

External Ids for MOK Gene

Previous HGNC Symbols for MOK Gene

  • RAGE

Previous GeneCards Identifiers for MOK Gene

  • GC14M102690

Summaries for MOK Gene

Entrez Gene Summary for MOK Gene

  • This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for MOK Gene

MOK (MOK Protein Kinase) is a Protein Coding gene. Diseases associated with MOK include kidney cancer and renal cell carcinoma. Among its related pathways are IL-2 Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAK.

UniProtKB/Swiss-Prot for MOK Gene

  • Able to phosphorylate several exogenous substrates and to undergo autophosphorylation.

Gene Wiki entry for MOK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOK Gene

Genomics for MOK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MOK Gene

Chromosome:
14
Start:
102,224,450 bp from pter
End:
102,305,200 bp from pter
Size:
80,751 bases
Orientation:
Minus strand

Genomic View for MOK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MOK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOK Gene

No data available for Regulatory Elements for MOK Gene

Proteins for MOK Gene

  • Protein details for MOK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ07-MOK_HUMAN
    Recommended name:
    MAPK/MAK/MRK overlapping kinase
    Protein Accession:
    Q9UQ07
    Secondary Accessions:
    • B2R6Z4
    • B7Z7P6
    • E7ER76
    • E7ERR8
    • Q92790
    • Q93067

    Protein attributes for MOK Gene

    Size:
    419 amino acids
    Molecular mass:
    48014 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB38087.1; Type=Frameshift; Positions=299; Evidence={ECO:0000305};

    Alternative splice isoforms for MOK Gene

neXtProt entry for MOK Gene

Proteomics data for MOK Gene at MOPED

Post-translational modifications for MOK Gene

Antibody Products

No data available for DME Specific Peptides for MOK Gene

Domains & Families for MOK Gene

Gene Families for MOK Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQ07

UniProtKB/Swiss-Prot:

MOK_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with MOK: view

Function for MOK Gene

Molecular function for MOK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation appears to increase the enzymatic activity.
UniProtKB/Swiss-Prot Function:
Able to phosphorylate several exogenous substrates and to undergo autophosphorylation.

Enzyme Numbers (IUBMB) for MOK Gene

Gene Ontology (GO) - Molecular Function for MOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10421840
GO:0004674 protein serine/threonine kinase activity TAS 10421840
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MOK: view
genes like me logo Genes that share phenotypes with MOK: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MOK

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MOK Gene

Localization for MOK Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOK Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOK Gene COMPARTMENTS Subcellular localization image for MOK gene
Compartment Confidence
endoplasmic reticulum 3
cytosol 2
golgi apparatus 2
nucleus 1

Gene Ontology (GO) - Cellular Components for MOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MOK: view

Pathways & Interactions for MOK Gene

SuperPathways for MOK Gene

Superpath Contained pathways
1 IL-2 Pathway
genes like me logo Genes that share pathways with MOK: view

Pathways by source for MOK Gene

1 Qiagen pathway for MOK Gene

Gene Ontology (GO) - Biological Process for MOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 10421840
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with MOK: view

No data available for SIGNOR curated interactions for MOK Gene

Drugs & Compounds for MOK Gene

(1) Drugs for MOK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for MOK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with MOK: view

Transcripts for MOK Gene

Unigene Clusters for MOK Gene

MOK protein kinase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MOK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5:
SP6: - - - - -
SP7: - - - -
SP8: - - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - - -
SP15: - - - - - - - - - - -
SP16: - - - -
SP17: - - - -
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26: - - -
SP27: - - - - - - - -
SP28: - - - -
SP29:
SP30:
SP31:
SP32:
SP33:
SP34:

ExUns: 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f ^ 17a · 17b ^ 18a · 18b · 18c · 18d ^ 19a · 19b ^ 20a · 20b ·
SP1: - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - - - - - - - - - - - - - - -
SP15: - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - - - - - - -
SP20: - - - - - - - - - - - - - - - -
SP21: - - - - - - - - - -
SP22: - - - - - - - - - - - - -
SP23: - - - - - - - - -
SP24: - - - - - - - - -
SP25: - - - - - - - - - - - - - - - - - - -
SP26:
SP27: - - - - - - - - - - - - - - - - - - - - - - - - -
SP28: - - - - - - - - - - - - - - - - - - - - - - -
SP29: - - - - - -
SP30: - - - -
SP31: - - - - - - -
SP32: - -
SP33:
SP34: - - - - - - - - - - -

ExUns: 20c · 20d · 20e · 20f · 20g · 20h ^ 21a · 21b · 21c · 21d · 21e · 21f ^ 22 ^ 23a · 23b · 23c ^ 24
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6:
SP7:
SP8:
SP9: - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - -
SP12:
SP13:
SP14: - - - -
SP15:
SP16: - - - - - - - - - - - - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22: - - - - - - - - - - - - -
SP23:
SP24:
SP25:
SP26:
SP27: - - - - - - - - - - - - -
SP28:
SP29:
SP30:
SP31:
SP32: - - - - - - - - - - - -
SP33:
SP34:

Relevant External Links for MOK Gene

GeneLoc Exon Structure for
MOK
ECgene alternative splicing isoforms for
MOK

Expression for MOK Gene

mRNA expression in normal human tissues for MOK Gene

mRNA differential expression in normal tissues according to GTEx for MOK Gene

This gene is overexpressed in Testis (x4.4).

SOURCE GeneReport for Unigene cluster for MOK Gene Hs.104119

mRNA Expression by UniProt/SwissProt for MOK Gene

Q9UQ07-MOK_HUMAN
Tissue specificity: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina
genes like me logo Genes that share expression patterns with MOK: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MOK Gene

Orthologs for MOK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MOK 35
  • 83.45 (n)
  • 82.08 (a)
MOK 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOK 35
  • 87.5 (n)
  • 84.62 (a)
MOK 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stk30 35
  • 83.57 (n)
  • 83.73 (a)
Stk30 16
Stk30 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAGE 35
  • 99.36 (n)
  • 99.28 (a)
MOK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mok 35
  • 91.13 (n)
  • 95.71 (a)
oppossum
(Monodelphis domestica)
Mammalia MOK 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MOK 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOK 35
  • 68.75 (n)
  • 64.66 (a)
MOK 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MOK 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mok 35
  • 67.53 (n)
  • 67.44 (a)
Str.2425 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.10381 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002515 35
  • 49.12 (n)
  • 38.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IME2 36
  • 18 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.27829 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToOne
Species with no ortholog for MOK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MOK Gene

ENSEMBL:
Gene Tree for MOK (if available)
TreeFam:
Gene Tree for MOK (if available)

Paralogs for MOK Gene

Paralogs for MOK Gene

genes like me logo Genes that share paralogs with MOK: view

Variants for MOK Gene

Sequence variations from dbSNP and Humsavar for MOK Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs954469 -- 102,257,172(+) TGTGA(A/C)TTAGG intron-variant
rs1052780 -- 102,229,069(-) GCATT(C/T)TAGGG utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1952956 -- 102,236,670(+) cccaa(C/T)agggt intron-variant
rs2183637 -- 102,283,421(+) GTTGC(C/T)GTTAT intron-variant
rs2210315 -- 102,298,483(+) gtttg(C/T)aaatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOK Gene

Variant ID Type Subtype PubMed ID
nsv1429 CNV Loss 18451855
esv22037 CNV Gain 19812545
esv2659155 CNV Deletion 23128226

Variation tolerance for MOK Gene

Residual Variation Intolerance Score: 57.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.38; 90.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOK Gene

HapMap Linkage Disequilibrium report
MOK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOK Gene

Disorders for MOK Gene

MalaCards: The human disease database

(2) MalaCards diseases for MOK Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
kidney cancer
  • renal cell carcinoma
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association
Search MOK in MalaCards View complete list of genes associated with diseases

Relevant External Links for MOK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOK
genes like me logo Genes that share disorders with MOK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOK Gene

Publications for MOK Gene

  1. Depressive status does not alter renal oxidative and immunological parameters during early diabetic nephropathy in rats. (PMID: 19536704) Rincon J. … Mosquera J. (World J. Biol. Psychiatry 2009) 23 67
  2. Amelioration of diabetic tubulointerstitial damage in liver-type fatty acid-binding protein transgenic mice. (PMID: 18854419) Kamijo-Ikemori A. … Kimura K. (Nephrol. Dial. Transplant. 2009) 23 67
  3. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. (PMID: 17417641) Tian J. … Coyle A.J. (Nat. Immunol. 2007) 23 67
  4. Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma. (PMID: 17549666) Stav D. … Sandbank J. (Int. J. Biol. Markers 2007) 23 67
  5. Autocrine S100B effects on astrocytes are mediated via RAGE. (PMID: 17254641) Ponath G. … Rothermundt M. (J. Neuroimmunol. 2007) 23 67

Products for MOK Gene

Sources for MOK Gene

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