Aliases for MOGS Gene
External Ids for MOGS Gene
Previous GeneCards Identifiers for MOGS Gene
This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for MOGS Gene
MOGS (Mannosyl-Oligosaccharide Glucosidase) is a Protein Coding gene. Diseases associated with MOGS include Congenital Disorder Of Glycosylation, Type Iib and Synchronous Multifocal Osteogenic Sarcoma. Among its related pathways are Transport to the Golgi and subsequent modification and Calnexin/calreticulin cycle. GO annotations related to this gene include mannosyl-oligosaccharide glucosidase activity and glucosidase activity.
UniProtKB/Swiss-Prot for MOGS Gene
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.