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Aliases for MOGS Gene

Aliases for MOGS Gene

  • Mannosyl-Oligosaccharide Glucosidase 2 3 5
  • Processing A-Glucosidase I 2 3 4
  • Glucosidase I 2 3
  • EC 3.2.1.106 4 63
  • GCS1 3 4
  • CDG2B 3
  • CWH41 3
  • DER7 3

External Ids for MOGS Gene

Previous GeneCards Identifiers for MOGS Gene

  • GC02M074542
  • GC02M074688
  • GC02M074425

Summaries for MOGS Gene

Entrez Gene Summary for MOGS Gene

  • This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for MOGS Gene

MOGS (Mannosyl-Oligosaccharide Glucosidase) is a Protein Coding gene. Diseases associated with MOGS include congenital disorder of glycosylation, type iib and gcs1-cdg. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include mannosyl-oligosaccharide glucosidase activity and glucosidase activity.

UniProtKB/Swiss-Prot for MOGS Gene

  • Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.

Gene Wiki entry for MOGS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOGS Gene

Genomics for MOGS Gene

Regulatory Elements for MOGS Gene

Promoters for MOGS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MOGS on UCSC Golden Path with GeneCards custom track

Genomic Location for MOGS Gene

Chromosome:
2
Start:
74,461,057 bp from pter
End:
74,465,410 bp from pter
Size:
4,354 bases
Orientation:
Minus strand

Genomic View for MOGS Gene

Genes around MOGS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOGS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOGS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOGS Gene

Proteins for MOGS Gene

  • Protein details for MOGS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13724-MOGS_HUMAN
    Recommended name:
    Mannosyl-oligosaccharide glucosidase
    Protein Accession:
    Q13724
    Secondary Accessions:
    • A8K938
    • F5H6D0
    • Q17RN9
    • Q8TCT5

    Protein attributes for MOGS Gene

    Size:
    837 amino acids
    Molecular mass:
    91918 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MOGS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOGS Gene

Proteomics data for MOGS Gene at MOPED

Selected DME Specific Peptides for MOGS Gene

Post-translational modifications for MOGS Gene

Other Protein References for MOGS Gene

Domains & Families for MOGS Gene

Graphical View of Domain Structure for InterPro Entry

Q13724

UniProtKB/Swiss-Prot:

MOGS_HUMAN :
  • Belongs to the glycosyl hydrolase 63 family.
Family:
  • Belongs to the glycosyl hydrolase 63 family.
genes like me logo Genes that share domains with MOGS: view

No data available for Gene Families for MOGS Gene

Function for MOGS Gene

Molecular function for MOGS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2).
UniProtKB/Swiss-Prot Function:
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.

Enzyme Numbers (IUBMB) for MOGS Gene

Gene Ontology (GO) - Molecular Function for MOGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004573 mannosyl-oligosaccharide glucosidase activity IBA,TAS --
genes like me logo Genes that share ontologies with MOGS: view
genes like me logo Genes that share phenotypes with MOGS: view

Human Phenotype Ontology for MOGS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MOGS Gene

MGI Knock Outs for MOGS:
  • Mogs tm1(KOMP)Vlcg

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for MOGS Gene

Localization for MOGS Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOGS Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOGS Gene COMPARTMENTS Subcellular localization image for MOGS gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 2
lysosome 2
vacuole 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MOGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with MOGS: view

Pathways & Interactions for MOGS Gene

genes like me logo Genes that share pathways with MOGS: view

UniProtKB/Swiss-Prot Q13724-MOGS_HUMAN

  • Pathway: Glycan metabolism; N-glycan degradation.

Gene Ontology (GO) - Biological Process for MOGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with MOGS: view

No data available for SIGNOR curated interactions for MOGS Gene

Drugs & Compounds for MOGS Gene

(3) Drugs for MOGS Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for MOGS Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Glucose
  • Roferose ST
  • (+)-Glucose
  • Anhydrous dextrose
  • Cerelose
  • Cerelose 2001
50-99-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with MOGS: view

Transcripts for MOGS Gene

Unigene Clusters for MOGS Gene

Mannosyl-oligosaccharide glucosidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOGS Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - - -
SP2: -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6: -

Relevant External Links for MOGS Gene

GeneLoc Exon Structure for
MOGS
ECgene alternative splicing isoforms for
MOGS

Expression for MOGS Gene

mRNA expression in normal human tissues for MOGS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MOGS Gene

This gene is overexpressed in Nasal epithelium (31.0) and Placenta (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MOGS Gene



SOURCE GeneReport for Unigene cluster for MOGS Gene Hs.516119

genes like me logo Genes that share expression patterns with MOGS: view

Protein tissue co-expression partners for MOGS Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MOGS Gene

Orthologs for MOGS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOGS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MOGS 35
  • 86.58 (n)
  • 87.23 (a)
MOGS 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOGS 35
  • 88.98 (n)
  • 90.16 (a)
MOGS 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mogs 35
  • 83.43 (n)
  • 86.79 (a)
Mogs 16
Mogs 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MOGS 35
  • 99.64 (n)
  • 99.4 (a)
MOGS 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gcs1 35
  • 82.91 (n)
  • 85.47 (a)
oppossum
(Monodelphis domestica)
Mammalia MOGS 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MOGS 36
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19530 35
zebrafish
(Danio rerio)
Actinopterygii mogs 35
  • 54.1 (n)
  • 49.69 (a)
mogs 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1597 35
  • 52.29 (n)
  • 47.06 (a)
CG1597 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F13H10.4 35
  • 45.91 (n)
  • 40.28 (a)
F13H10.4 36
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CWH41 36
  • 28 (a)
OneToOne
CWH41 38
thale cress
(Arabidopsis thaliana)
eudicotyledons GCS1 35
  • 46.79 (n)
  • 41.28 (a)
rice
(Oryza sativa)
Liliopsida Os01g0921200 35
  • 48.46 (n)
  • 42.41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for MOGS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MOGS Gene

ENSEMBL:
Gene Tree for MOGS (if available)
TreeFam:
Gene Tree for MOGS (if available)

Paralogs for MOGS Gene

(1) SIMAP similar genes for MOGS Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MOGS: view

No data available for Paralogs for MOGS Gene

Variants for MOGS Gene

Sequence variations from dbSNP and Humsavar for MOGS Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_018966 Type IIb congenital disorder of glycosylation (CDGIIb)
VAR_018967 Type IIb congenital disorder of glycosylation (CDGIIb)
rs1063587 - 74,463,260(-) CCAGT(C/G)AACTT reference, missense
rs1063588 - 74,463,251(-) TTGGT(A/G)ACTTC reference, missense
rs3213671 - 74,463,302(-) AGGTT(A/G)GGGCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MOGS Gene

Variant ID Type Subtype PubMed ID
dgv1199e1 CNV Complex 17122850
nsv458185 CNV Loss 19166990
nsv515851 CNV Loss 19592680
dgv4166n71 CNV Loss 21882294

Variation tolerance for MOGS Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOGS Gene

HapMap Linkage Disequilibrium report
MOGS
Human Gene Mutation Database (HGMD)
MOGS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOGS Gene

Disorders for MOGS Gene

MalaCards: The human disease database

(6) MalaCards diseases for MOGS Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, and DISEASES

Disorder Aliases PubMed IDs
congenital disorder of glycosylation, type iib
  • type iib congenital disorder of glycosylation
gcs1-cdg
  • congenital disorder of glycosylation, type iib
synchronous multifocal osteogenic sarcoma
  • synchronous multifocal osteosarcoma
multifocal osteogenic sarcoma
  • multifocal osteosarcoma
sporotrichosis
  • rose gardener's disease
- elite association - COSMIC cancer census association via MalaCards
Search MOGS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MOGS_HUMAN
  • Type IIb congenital disorder of glycosylation (CDGIIb) [MIM:606056]: Characterized by marked generalized hypotonia and hypomotility of the neonate, dysmorphic features, including a prominent occiput, short palpebral fissures, retrognathia, high arched palate, generalized edema, and hypoplastic genitalia. Symptoms of the infant included hepatomegaly, hypoventilation, feeding problems and seizures. The clinical course was progressive and the infant did not survive more than a few months. {ECO:0000269 PubMed:10788335}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MOGS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOGS
genes like me logo Genes that share disorders with MOGS: view

No data available for Genatlas for MOGS Gene

Publications for MOGS Gene

  1. Cloning and expression of glucosidase I from human hippocampus. (PMID: 7635146) Kalz-Fueller B. … Bause E. (Eur. J. Biochem. 1995) 2 3 4 23 67
  2. (Arg)3 within the N-terminal domain of glucosidase I contains ER targeting information but is not required absolutely for ER localization. (PMID: 12626409) Hardt B. … Bause E. (Glycobiology 2003) 3 23
  3. Processing of N-linked carbohydrate chains in a patient with glucosidase I deficiency (CDG type IIb). (PMID: 12145188) Voelker C. … Bause E. (Glycobiology 2002) 3 23
  4. A novel disorder caused by defective biosynthesis of N-linked oligosaccharides due to glucosidase I deficiency. (PMID: 10788335) De Praeter C.M. … Van Coster R.N. (Am. J. Hum. Genet. 2000) 3 23
  5. Localization of the human glucosidase I gene to chromosome 2p12-p13 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids. (PMID: 8786151) Kalz-FA1ller B. … Schwanitz G. (Genomics 1996) 2 3

Products for MOGS Gene

Sources for MOGS Gene

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