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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MOGS Gene

protein-coding   GIFtS: 61
GCID: GC02M074688

mannosyl-oligosaccharide glucosidase

 Explore 10 diseases affiliated with
MOGS via our new
 Human Malady Compendium 
Biological research products
for MOGS
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mannosyl-Oligosaccharide Glucosidase1 2     Processing A-Glucosidase I2 3
GCS11 2 3 5     EC 3.2.1.1063 8
CWH411 2     CDG2B2 5
DER71 2     Glucosidase I2

External Ids:    HGNC: 248621   Entrez Gene: 78412   Ensembl: ENSG000001152757   OMIM: 6013365   UniProtKB: Q137243   

Export aliases for MOGS gene to outside databases

Previous GC identifers: GC02M074542 GC02M074425


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MOGS:
This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal
alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located
in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of
glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. (provided
by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: MOGS_HUMAN, Q13724
Function: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor
in a highly specific manner

Gene Wiki entry for MOGS (GCS1)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MOGS gene promoter:
         ER-alpha   GR   NF-1/L   Elk-1   NF-1   GCNF   MyoD   GCNF-1   GR-alpha   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOGS promoter sequence
   Search SABiosciences Chromatin IP Primers for MOGS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOGS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.1

MOGS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOGS gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M074688:  view genomic region     (about GC identifiers)

Start:
74,688,184 bp from pter      End:
74,692,537 bp from pter
Size:
4,354 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MOGS_HUMAN, Q13724 (See protein sequence)
Recommended Name: Mannosyl-oligosaccharide glucosidase  
Size: 837 amino acids; 91918 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein
Secondary accessions: A8K938 Q17RN9 Q8TCT5

Explore the universe of human proteins at neXtProt for MOGS: NX_Q13724

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13724

  • 3 DME Specific Peptides for MOGS (Q13724)
     HLDLRCW  LLGGIGYFYG  FFPRGFLWDEGFHQ 

    MOGS Protein expression data from MOPED and PaxDb:    About this image 
    MOGS Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001139630.1  NP_006293.2  

    ENSEMBL proteins: 
     ENSP00000233616   ENSP00000386493   ENSP00000410992   ENSP00000396298   ENSP00000388201  
     ENSP00000439971  
    Reactome Protein details: Q13724
    Human Recombinant Protein Products for MOGS: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MOGS

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005783endoplasmic reticulum TAS7635146
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane TAS7635146
    GO:0016021integral to membrane IEA--

    MOGS for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MOGS for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004888 Glycoside_hydrolase_63
     IPR008928 6-hairpin_glycosidase-like

    Graphical View of Domain Structure for InterPro Entry Q13724

    ProtoNet protein and cluster: Q13724

    1 Blocks protein family: IPB004888 Glycoside hydrolase

    UniProtKB/Swiss-Prot: MOGS_HUMAN, Q13724
    Similarity: Belongs to the glycosyl hydrolase 63 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOGS_HUMAN, Q13724
    Function: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor
    in a highly specific manner
    Catalytic activity: Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide
    Glc(3)Man(9)GlcNAc(2)

         Enzyme Number (IUBMB): EC 3.2.1.1061 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004573mannosyl-oligosaccharide glucosidase activity IEA--
    GO:0015926glucosidase activity TAS7635146
         
    MOGS for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MOGS 

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    hsa-miR-4324 hsa-miR-181c hsa-miR-130a* hsa-miR-23c hsa-miR-181a hsa-miR-181d hsa-miR-23b hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidMOGS 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOGS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation1.00
    Post-translational protein modification0.44
    N-Glycan biosynthesis0.52
    Metabolism of proteins0.15
    2Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum1.00
    3Calnexin/calreticulin cycle
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle0.85
    4Metabolism
    Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for MOGS
        Asparagine N-linked glycosylation
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle
    Metabolism of proteins
    Post-translational protein modification


    3         Kegg Pathways  (Kegg details for MOGS):
        N-Glycan biosynthesis
    Metabolic pathways
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: MOGS_HUMAN, Q13724
    Pathway: Glycan metabolism; N-glycan degradation


    MOGS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOGS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for MOGS (Q137242, 3 ENSP000002336164) via UniProtKB, MINT, STRING, and/or I2D (see all 63)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHGBP050602, 3MINT-64148 I2D: score=5 
    TIMM44O436153, ENSP000002705384I2D: score=5 STRING: ENSP00000270538
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    PSMD3O432423, ENSP000002646394I2D: score=3 STRING: ENSP00000264639
    ALG5Q9Y6733, ENSP000002398914I2D: score=1 STRING: ENSP00000239891
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0006487protein N-linked glycosylation TAS7635146
    GO:0009311oligosaccharide metabolic process IEA--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--

    MOGS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MOGS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MOGS
    7 Novoseek chemical compound relationships for MOGS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    castanospermine 90.1 9 1832085 (1), 12383251 (1), 1402401 (1), 15893367 (1) (see all 7)
    1-deoxynojirimycin 85.7 10 14718372 (3), 1650361 (1), 9271078 (1), 11401481 (1) (see all 5)
    kifunensine 81.7 1 15893367 (1)
    polysaccharide 60 8 7592804 (2), 9234902 (1), 7635146 (1), 8910335 (1) (see all 7)
    mannose 46.5 1 9647663 (1)
    glucose 43.8 8 1828762 (1), 9363442 (1), 1650361 (1), 7635146 (1) (see all 8)
    histidine 15.2 1 9647663 (1)

    Search CenterWatch for drugs/clinical trials and news about MOGS 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MOGS gene (2 alternative transcripts): 
    NM_001146158.1  NM_006302.2  

    Unigene Cluster for MOGS:

    Mannosyl-oligosaccharide glucosidase
    Hs.516119  [show with all ESTs]
    Unigene Representative Sequence: NM_006302
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233616(uc010yrt.2 uc010ffi.3 uc010ffj.3) ENST00000409065
    ENST00000462189(uc010ffh.3) ENST00000448666 ENST00000462443 ENST00000489655
    ENST00000414701 ENST00000486036 ENST00000452063 ENST00000535045(uc010yru.1)


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    hsa-miR-4324 hsa-miR-181c hsa-miR-130a* hsa-miR-23c hsa-miR-181a hsa-miR-181d hsa-miR-23b hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidMOGS 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK292553.1 AK292719.1 AK304655.1 AK307991.1 AK313355.1 BC002804.2 BC028337.1 BC117250.1 
    BC117252.1 BC143934.1 X87237.1 

    19 DOTS entries:

    DT.100783565  DT.451606  DT.95182363  DT.91770816  DT.91770826  DT.100783569  DT.120976867  DT.120976780 
    DT.91770823  DT.102825071  DT.451605  DT.91770813  DT.91846161  DT.91990264  DT.95182385  DT.100783572 
    DT.100823662  DT.95134975  DT.95182362 

    24/134 AceView cDNA sequences (see all 134):

    BQ631735 BM782318 BU858999 BU845915 AW137193 BE501715 CD672611 AU131538 
    BE336935 AA368657 BC028337 AW137195 BP356961 BQ632031 BM563651 BU845735 
    BM920234 BI118022 BP430622 BI462509 AL569755 BX440726 AL561337 BE615799 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MOGS (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
    SP1:                    -     -           -     -                                             
    SP2:                                            -                                             
    SP3:                    -     -     -     -     -                                             
    SP4:                    -     -     -           -                                             
    SP5:                                      -     -                                             


    ECgene alternative splicing isoforms for MOGS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MOGS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCACTCTGGC
    MOGS Expression
    About this image
    See MOGS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MOGS

    SOURCE GeneReport for Unigene cluster: Hs.516119
        SABiosciences Expression via Pathway-Focused PCR Array including MOGS: 

              Glycosylation in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MOGS gene from 9/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mogs1 , 5 mannosyl-oligosaccharide glucosidase1, 5 83.43(n)1
    86.79(a)1
      6 (35.94 cM)5
    573771  NM_020619.21  NP_065644.21 
     831154965 
    lizard
    (Anolis carolinensis)
    Reptilia MOGS6
    --
    53(a)
    1 ↔ 1
    GL344203.1(22424-27941)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.195302 Xenopus laevis transcribed sequence with weak similarity more 75.34(n)    BJ621888.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mogs1 mannosyl-oligosaccharide glucosidase 54.59(n)
    50.12(a)
      567913  NM_001080190.1  NP_001073659.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15971 CG1597 52.43(n)
    47.06(a)
      32073  NM_132479.2  NP_572707.4 
    worm
    (Caenorhabditis elegans)
    Secernentea F13H10.41 Protein F13H10.4 49.29(n)
    45.3(a)
      177998  NM_001129299.1  NP_001122771.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CWH41(YGL027C)4
    CWH411
    Processing alpha glucosidase I, ER type II integral more4
    Cwh41p1
    43.1(n)1
    35.5(a)1
      7(446143-443642)4
    8528571, 4  NP_011488.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GCS11 glucosidase 1 47.26(n)
    41.25(a)
      843070  NM_105416.4  NP_176916.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g09212001 hypothetical protein 48.44(n)
    41.1(a)
      4327748  NM_001051760.2  NP_001045225.2 


    ENSEMBL Gene Tree for MOGS (if available)
    TreeFam Gene Tree for MOGS (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/112 NCBI SNPs in MOGS are shown (see all 112    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs46861,2
    C--74687877(-) CCAAAG/AGAACG 4 -- ds5001 ut31 nc-transcript-variant3Minor allele frequency- A:0.49MN NA 374
    rs1436735451,2
    --74687886(+) GGCCCC/GTCCCT 4 -- ds5001 ut31 nc-transcript-variant0--------
    rs1181560651,2
    C,F--74687960(+) ACCCCC/TGCAGG 4 -- ds5001 ut31 nc-transcript-variant1Minor allele frequency- T:0.02EA 120
    rs1903874941,2
    --74687961(+) CCCCCA/GCAGGA 4 -- nc-transcript-variantds5001 ut310--------
    rs1814706291,2
    --74688051(+) CTGCAC/TTGCAC 4 -- ds50010--------
    rs1857654071,2
    --74688293(+) ATGAGA/GAAGGT 4 -- ds5001 ut310--------
    rs2018235851,2
    --74688403(+) CCCTTC/TAGTAG 6 * ds5001 syn10--------
    rs2008897201,2
    --74688438(+) AGGCTA/GGTCCA 6 T syn1 ds50010--------
    rs2000149451,2
    --74688460(+) GGCGGC/TAGCCC 6 Y C ds5001 mis10--------
    rs355337731,2
    C,F--74688563(-) TCCACG/AGTGAG 4 /S /G mis19Minor allele frequency- A:0.02NA NS EA CSA WA EU 1915

    HapMap Linkage Disequilibrium report for MOGS (74688184 - 74692537 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for MOGS
         3 CNVs: 50556 3366 50558
    Human Gene Mutation Database (HGMD): MOGS

    Locus Specific Mutation Databases (LSDB): MOGS

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MOGS
    DNA2.0 Custom Variant and Variant Library Synthesis for MOGS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MOGS for disorders           About GeneDecksing

    OMIM gene information: 601336   
    OMIM disorders: 606056  
    UniProtKB/Swiss-Prot: MOGS_HUMAN, Q13724
  • Defects in MOGS are the cause of type IIb congenital disorder of glycosylation (CDGIIb) [MIM:606056]; also
  • known as glucosidase I deficiency. CDGIIb is characterized by marked generalized hypotonia and hypomotility of the
    neonate, dysmorphic features, including a prominent occiput, short palpebral fissures, retrognathia, high arched
    palate, generalized edema, and hypoplastic genitalia. Symptoms of the infant included hepatomegaly, hypoventilation,
    feeding problems and seizures. The clinical course was progressive and the infant did not survive more than a few
    months

    10 diseases for MOGS:    About MalaCards
    congenital disorder of glycosylation    glucosidase i deficiency    gaucher's disease    stomach carcinoma
    protein s deficiency    hypotonia    influenza    carcinoma
    immunodeficiency    hiv type 1

    2 Novoseek disease relationships for MOGS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congenital disorders 46.9 1 12145188 (1)
    carcinoma 0 1 10706129 (1)

    GeneTests: MOGS
    Congenital Disorders of Glycosylation


    Export disorders for MOGS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MOGS gene, integrated from 9 sources (see all 85):
    (articles sorted by number of sources associating them with MOGS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of glucosidase I from human hippocampus. (PubMed id 7635146)1, 2, 3, 9 Kalz-Fueller B.... Bause E. (1995)
    2. Processing of N-linked carbohydrate chains in a patient with glucosidase I deficiency (CDG type IIb). (PubMed id 12145188)1, 2, 9 Voelker C.... Bause E. (2002)
    3. A novel disorder caused by defective biosynthesis of N-linked oligosaccharides due to glucosidase I deficiency. (PubMed id 10788335)1, 2, 9 De Praeter C.M....Van Coster R.N. (2000)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Localization of the human glucosidase I gene to chromosome 2p12-p13 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids. (PubMed id 8786151)1, 3 Kalz-Fuller B....Schwanitz G. (1996)
    6. (Arg)3 within the N-terminal domain of glucosidase I contains ER targeting information but is not required absolutely for ER localization. (PubMed id 12626409)1, 9 Hardt B....Bause E. (2003)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7841 HGNC: 24862 AceView: GCS1 Ensembl:ENSG00000115275 euGenes: HUgn7841
    ECgene: MOGS Kegg: 7841 H-InvDB: MOGS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MOGS Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GCS1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MOGS gene:
    Search GeneIP for patents involving MOGS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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