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MOGS Gene

protein-coding   GIFtS: 63
GCID: GC02M074688

Mannosyl-Oligosaccharide Glucosidase

  See MOGS-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mannosyl-Oligosaccharide Glucosidase1 2     EC 3.2.1.1063 8
Processing A-Glucosidase I1 2 3     CDG2B2 5
GCS12 3 5     CWH412
Glucosidase I1 2     DER72

External Ids:    HGNC: 248621   Entrez Gene: 78412   Ensembl: ENSG000001152757   OMIM: 6013365   UniProtKB: Q137243   

Export aliases for MOGS gene to outside databases

Previous GC identifers: GC02M074542 GC02M074425


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MOGS Gene:
This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the
distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein
is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital
disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Mar 2009)

GeneCards Summary for MOGS Gene:
MOGS (mannosyl-oligosaccharide glucosidase) is a protein-coding gene. Diseases associated with MOGS include congenital disorder of glycosylation type 2b, and diamond-blackfan anemia 1. GO annotations related to this gene include glucosidase activity and mannosyl-oligosaccharide glucosidase activity.

UniProtKB/Swiss-Prot: MOGS_HUMAN, Q13724
Function: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide
precursor in a highly specific manner

Gene Wiki entry for MOGS (GCS1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MOGS gene promoter:
         ER-alpha   GR   NF-1/L   Elk-1   NF-1   GCNF   MyoD   GCNF-1   GR-alpha   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOGS promoter sequence
   Search Chromatin IP Primers for MOGS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MOGS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.1

MOGS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOGS gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M074688:  view genomic region     (about GC identifiers)

Start:
74,688,184 bp from pter      End:
74,692,537 bp from pter
Size:
4,354 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MOGS_HUMAN, Q13724 (See protein sequence)
Recommended Name: Mannosyl-oligosaccharide glucosidase  
Size: 837 amino acids; 91918 Da
Secondary accessions: A8K938 F5H6D0 Q17RN9 Q8TCT5
Alternative splicing: 2 isoforms:  Q13724-1   Q13724-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for MOGS: NX_Q13724

Explore proteomics data for MOGS at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys576
  • Glycosylation2 at Asn657
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for MOGS (Q13724)
     HLDLRCW  LLGGIGYFYG  FFPRGFLWDEGFHQ 


    See MOGS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139630.1  NP_006293.2  

    ENSEMBL proteins: 
     ENSP00000233616   ENSP00000386493   ENSP00000410992   ENSP00000396298   ENSP00000388201  
     ENSP00000439971  
    Reactome Protein details: Q13724

    MOGS Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MOGS
    GenScript Custom Purified and Recombinant Proteins Services for MOGS
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MOGS

     
    Search eBioscience for Proteins for MOGS 

    MOGS Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals MOGS Antibodies
    Abcam antibodies for MOGS
    Cloud-Clone Corp. Antibodies for MOGS
    ThermoFisher Antibodies for MOGS
    LSBio Antibodies in human, mouse, rat for MOGS

    MOGS Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MOGS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MOGS
    Cloud-Clone Corp. CLIAs for MOGS
    Search eBioscience for ELISAs for MOGS 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004888 Glycoside_hydrolase_63
     IPR008928 6-hairpin_glycosidase-like

    Graphical View of Domain Structure for InterPro Entry Q13724

    ProtoNet protein and cluster: Q13724

    1 Blocks protein domain: IPB004888 Glycoside hydrolase

    UniProtKB/Swiss-Prot: MOGS_HUMAN, Q13724
    Similarity: Belongs to the glycosyl hydrolase 63 family


    Find genes that share domains with MOGS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOGS_HUMAN, Q13724
    Function: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide
    precursor in a highly specific manner
    Catalytic activity: Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide
    Glc(3)Man(9)GlcNAc(2)

         Enzyme Number (IUBMB): EC 3.2.1.1061 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004573mannosyl-oligosaccharide glucosidase activity IEA--
    GO:0015926glucosidase activity TAS7635146
         
    Find genes that share ontologies with MOGS           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MOGS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MOGS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MOGS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MOGS

    miRNA
    Products:
        
    miRTarBase miRNAs that target MOGS:
    hsa-mir-378a-5p (MIRT043996), hsa-mir-615-3p (MIRT039951), hsa-mir-877-3p (MIRT037160), hsa-mir-423-3p (MIRT042520), hsa-mir-124-3p (MIRT022588)

    Block miRNA regulation of human, mouse, rat MOGS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MOGS (see all 14):
    hsa-miR-4324 hsa-miR-181c hsa-miR-130a* hsa-miR-23c hsa-miR-181a hsa-miR-181d hsa-miR-23b hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidMOGS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MOGS
    Predesigned siRNA for gene silencing in human, mouse, rat MOGS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MOGS

    Clone
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    OriGene clones in human, mouse for MOGS (see all 13)
    OriGene ORF clones in mouse, rat for MOGS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MOGS (NM_006302)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOGS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOGS

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MOGS
    Browse ESI BIO Cell Lines and PureStem Progenitors for MOGS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOGS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MOGS_HUMAN, Q13724: Endoplasmic reticulum membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus2
    cytosol1
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS7635146
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane TAS7635146
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with MOGS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MOGS About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Metabolism of proteins0.30
    N-Glycan biosynthesis0.49
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle0.00
    Post-translational protein modification0.43
    2Metabolism
    Metabolic pathways0.38
    3Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with MOGS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for MOGS
        N-glycan trimming in the ER and Calnexin/Calreticulin cycle


    3 Kegg Pathways  (Kegg details for MOGS):
        N-Glycan biosynthesis
    Metabolic pathways
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: MOGS_HUMAN, Q13724
    Pathway: Glycan metabolism; N-glycan degradation

        Pathway & Disease-focused RT2 Profiler PCR Array including MOGS: 

              Glycosylation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MOGS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MOGS (Q137242, 3 ENSP000002336164) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHGBP050602, 3MINT-64148 I2D: score=5 
    TIMM44O436153, ENSP000002705384I2D: score=5 STRING: ENSP00000270538
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    PSMD3O432423, ENSP000002646394I2D: score=3 STRING: ENSP00000264639
    ALG5Q9Y6733, ENSP000002398914I2D: score=1 STRING: ENSP00000239891
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0006487protein N-linked glycosylation TAS7635146
    GO:0009311oligosaccharide metabolic process IEA--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--

    Find genes that share ontologies with MOGS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MOGS

    7 Novoseek inferred chemical compound relationships for MOGS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    castanospermine 90.1 9 1832085 (1), 12383251 (1), 1402401 (1), 15893367 (1) (see all 7)
    1-deoxynojirimycin 85.7 10 14718372 (3), 1650361 (1), 9271078 (1), 11401481 (1) (see all 5)
    kifunensine 81.7 1 15893367 (1)
    polysaccharide 60 8 7592804 (2), 9234902 (1), 7635146 (1), 8910335 (1) (see all 7)
    mannose 46.5 1 9647663 (1)
    glucose 43.8 8 1828762 (1), 9363442 (1), 1650361 (1), 7635146 (1) (see all 8)
    histidine 15.2 1 9647663 (1)



    Find genes that share compounds with MOGS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MOGS gene (2 alternative transcripts): 
    NM_001146158.1  NM_006302.2  

    Unigene Cluster for MOGS:

    Mannosyl-oligosaccharide glucosidase
    Hs.516119  [show with all ESTs]
    Unigene Representative Sequence: NM_006302
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233616(uc010yrt.2 uc010ffi.3 uc010ffj.3) ENST00000409065
    ENST00000462189(uc010ffh.3) ENST00000448666 ENST00000462443 ENST00000489655
    ENST00000414701 ENST00000486036 ENST00000452063 ENST00000535045(uc010yru.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MOGS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MOGS (see all 14):
    hsa-miR-4324 hsa-miR-181c hsa-miR-130a* hsa-miR-23c hsa-miR-181a hsa-miR-181d hsa-miR-23b hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidMOGS 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MOGS
    Predesigned siRNA for gene silencing in human, mouse, rat MOGS
    Clone
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    OriGene clones in human, mouse for MOGS (see all 13)
    OriGene ORF clones in mouse, rat for MOGS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MOGS (NM_006302)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOGS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOGS
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MOGS
    OriGene qSTAR qPCR primer pairs in human, mouse for MOGS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MOGS
      QuantiTect SYBR Green Assays in human, mouse, rat MOGS
      QuantiFast Probe-based Assays in human, mouse, rat MOGS

    Additional mRNA sequence: 

    AK292553.1 AK292719.1 AK304655.1 AK307991.1 AK313355.1 BC002804.2 BC028337.1 BC117250.1 
    BC117252.1 BC143934.1 X87237.1 

    18 DOTS entries:

    DT.100783565  DT.451606  DT.95182363  DT.91770826  DT.100783569  DT.120976867  DT.120976780  DT.91770823 
    DT.102825071  DT.451605  DT.91770813  DT.91990264  DT.95182385  DT.100823662  DT.91846161  DT.95134975 
    DT.95182362  DT.100783572 

    Selected AceView cDNA sequences (see all 134):

    BM782318 BM563651 BE336935 AA368657 AW137193 BU858999 BC028337 BE501715 
    BU845915 BQ631735 BU845735 BP356961 BQ632031 AU131538 BM920234 AW137195 
    CD672611 AL559501 BI561027 W30951 BI911603 BE728995 BM548856 BM043755 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MOGS (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
    SP1:                    -     -           -     -                                             
    SP2:                                            -                                             
    SP3:                    -     -     -     -     -                                             
    SP4:                    -     -     -           -                                             
    SP5:                                      -     -                                             


    ECgene alternative splicing isoforms for MOGS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MOGS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACTCTGGC
    MOGS Expression
    About this image


    MOGS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    MOGS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MOGS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516119
        Pathway & Disease-focused RT2 Profiler PCR Array including MOGS: 
              Glycosylation in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for MOGS
    OriGene qSTAR qPCR primer pairs in human, mouse for MOGS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MOGS
    QuantiTect SYBR Green Assays in human, mouse, rat MOGS
    QuantiFast Probe-based Assays in human, mouse, rat MOGS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOGS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MOGS gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mogs1 , 5 mannosyl-oligosaccharide glucosidase1, 5 83.43(n)1
    86.79(a)1
      6 (35.94 cM)5
    573771  NM_020619.21  NP_065644.21 
     831154965 
    lizard
    (Anolis carolinensis)
    Reptilia MOGS6
    mannosyl-oligosaccharide glucosidase
    52(a)
    1 ↔ 1
    GL344203.1(19304-30311)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.195302 Xenopus laevis transcribed sequence with weak similarity more 75.34(n)    BJ621888.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mogs1 mannosyl-oligosaccharide glucosidase 54.1(n)
    49.69(a)
      567913  NM_001080190.1  NP_001073659.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15971 CG1597 52.29(n)
    47.06(a)
      32073  NM_132479.2  NP_572707.4 
    worm
    (Caenorhabditis elegans)
    Secernentea F13H10.41 F13H10.4 45.91(n)
    40.28(a)
      177998  NM_001129299.2  NP_001122771.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CWH41(YGL027C)4 Processing alpha glucosidase I, ER type II integral more   --   7(446143-443642) 852857  NP_011488.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GCS11 GCS1 46.79(n)
    41.28(a)
      843070  NM_105416.4  NP_176916.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g09212001 Os01g0921200 48.46(n)
    42.41(a)
      4327748  NM_001051760.2  NP_001045225.2 


    ENSEMBL Gene Tree for MOGS (if available)
    TreeFam Gene Tree for MOGS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MOGS gene
    1 SIMAP similar gene for MOGS using alignment to 5 protein entries:     MOGS_HUMAN (see all proteins):
    GCS1

    Find genes that share paralogs with MOGS           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MOGS (see all 191)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0189674
    Type IIb congenital disorder of glycosylation (CDGIIb)4--see VAR_0189672 F L mis40--------
    VAR_0189664
    Type IIb congenital disorder of glycosylation (CDGIIb)4--see VAR_0189662 R T mis40--------
    rs1997140631,2
    --74558954(+) TGCCAC/GATCTG 2 -- ds50010--------
    rs617334701,2
    C,F--74559022(+) GGGCTG/ATCTTC 2 -- ds50013Minor allele frequency- A:0.03NS NA EU 5173
    rs46861,2
    C--74559118(-) CCAAAG/AGAACG 2 -- ds50013Minor allele frequency- A:0.49MN NA 374
    rs1436735451,2
    --74559127(+) GGCCCC/GTCCCT 2 -- ds50010--------
    rs1181560651,2
    C,F--74559201(+) ACCCCC/TGCAGG 2 -- ds50011Minor allele frequency- T:0.02EA 120
    rs1903874941,2
    --74559202(+) CCCCCA/GCAGGA 2 -- ds50010--------
    rs1814706291,2
    --74559292(+) CTGCAC/TTGCAC 2 -- ds50010--------
    rs1857654071,2
    --74559534(+) ATGAGA/GAAGGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MOGS (74688184 - 74692537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MOGS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458185CNV Loss19166990
    nsv515851CNV Loss19592680
    dgv4166n71CNV Loss21882294
    dgv1199e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): MOGS
    Locus Specific Mutation Databases (LSDB): MOGS

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MOGS
    DNA2.0 Custom Variant and Variant Library Synthesis for MOGS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601336   
    OMIM disorders: 606056  
    UniProtKB/Swiss-Prot: MOGS_HUMAN, Q13724
  • Type IIb congenital disorder of glycosylation (CDGIIb) [MIM:606056]: Characterized by marked generalized
    hypotonia and hypomotility of the neonate, dysmorphic features, including a prominent occiput, short palpebral
    fissures, retrognathia, high arched palate, generalized edema, and hypoplastic genitalia. Symptoms of the infant
    included hepatomegaly, hypoventilation, feeding problems and seizures. The clinical course was progressive and
    the infant did not survive more than a few months. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 2 diseases for MOGS:    
    About MalaCards
    congenital disorder of glycosylation type 2b    diamond-blackfan anemia 1


    Find genes that share disorders with MOGS           About GenesLikeMe

    2 Novoseek inferred disease relationships for MOGS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congenital disorders 46.9 1 12145188 (1)
    carcinoma 0 1 10706129 (1)

    GeneTests: MOGS
    GeneReviews: MOGS

    Export disorders for MOGS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MOGS gene, integrated from 10 sources (see all 88):
    (articles sorted by number of sources associating them with MOGS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of glucosidase I from human hippocampus. (PubMed id 7635146)1, 2, 3, 9 Kalz-Fueller B.... Bause E. (Eur. J. Biochem. 1995)
    2. Processing of N-linked carbohydrate chains in a patient with glucosidase I deficiency (CDG type IIb). (PubMed id 12145188)1, 2, 9 Voelker C.... Bause E. (Glycobiology 2002)
    3. A novel disorder caused by defective biosynthesis of N-linked oligosaccharides due to glucosidase I deficiency. (PubMed id 10788335)1, 2, 9 De Praeter C.M....Van Coster R.N. (Am. J. Hum. Genet. 2000)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Localization of the human glucosidase I gene to chromosome 2p12-p13 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids. (PubMed id 8786151)1, 3 Kalz-FA1ller B....Schwanitz G. (Genomics 1996)
    6. (Arg)3 within the N-terminal domain of glucosidase I contains ER targeting information but is not required absolutely for ER localization. (PubMed id 12626409)1, 9 Hardt B....Bause E. (Glycobiology 2003)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. (PubMed id 23246001)1 Xu Y....Ye Y. (Cell Rep 2012)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7841 HGNC: 24862 AceView: GCS1 Ensembl:ENSG00000115275 euGenes: HUgn7841
    ECgene: MOGS Kegg: 7841 H-InvDB: MOGS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MOGS Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=GCS1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MOGS gene:
    Search GeneIP for patents involving MOGS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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