Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MOGS Gene

protein-coding   GIFtS: 62
GCID: GC02M074688

Mannosyl-Oligosaccharide Glucosidase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mannosyl-Oligosaccharide Glucosidase1 2     EC 3.2.1.1063 8
Processing A-Glucosidase I1 2 3     CDG2B2 5
GCS12 3 5     CWH412
Glucosidase I1 2     DER72

External Ids:    HGNC: 248621   Entrez Gene: 78412   Ensembl: ENSG000001152757   OMIM: 6013365   UniProtKB: Q137243   

Export aliases for MOGS gene to outside databases

Previous GC identifers: GC02M074542 GC02M074425


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MOGS Gene:
This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the
distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein
is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital
disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Mar 2009)

GeneCards Summary for MOGS Gene: 
MOGS (mannosyl-oligosaccharide glucosidase) is a protein-coding gene. Diseases associated with MOGS include congenital disorder of glycosylation, and gaucher's disease, and among its related super-pathways are WNT ligand biogenesis and trafficking and Calnexin/calreticulin cycle. GO annotations related to this gene include glucosidase activity and mannosyl-oligosaccharide glucosidase activity.

UniProtKB/Swiss-Prot: MOGS_HUMAN, Q13724
Function: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide
precursor in a highly specific manner

Gene Wiki entry for MOGS (GCS1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MOGS gene promoter:
         ER-alpha   GR   NF-1/L   Elk-1   NF-1   GCNF   MyoD   GCNF-1   GR-alpha   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOGS promoter sequence
   Search SABiosciences Chromatin IP Primers for MOGS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOGS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.1

MOGS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOGS gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M074688:  view genomic region     (about GC identifiers)

Start:
74,688,184 bp from pter      End:
74,692,537 bp from pter
Size:
4,354 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MOGS_HUMAN, Q13724 (See protein sequence)
Recommended Name: Mannosyl-oligosaccharide glucosidase  
Size: 837 amino acids; 91918 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein
Secondary accessions: A8K938 F5H6D0 Q17RN9 Q8TCT5
Alternative splicing: 2 isoforms:  Q13724-1   Q13724-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for MOGS: NX_Q13724

Explore proteomics data for MOGS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13724

  • 3 DME Specific Peptides for MOGS (Q13724)
     HLDLRCW  LLGGIGYFYG  FFPRGFLWDEGFHQ 

    MOGS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MOGS Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001139630.1  NP_006293.2  

    ENSEMBL proteins: 
     ENSP00000233616   ENSP00000386493   ENSP00000410992   ENSP00000396298   ENSP00000388201  
     ENSP00000439971  
    Reactome Protein details: Q13724
    Human Recombinant Protein Products for MOGS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MOGS
    GenScript Custom Purified and Recombinant Proteins Services for MOGS
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MOGS 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS7635146
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane TAS7635146
    GO:0016021integral to membrane IEA--

    MOGS for ontologies           About GeneDecksing



    MOGS Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MOGS
    GenScript Custom Superior Antibodies Services for MOGS
    Novus Biologicals MOGS Antibodies
    Abcam antibodies for MOGS
    Cloud-Clone Corp. Antibodies for MOGS 
    ThermoFisher Antibodies for MOGS
    LSBio Antibodies in human, mouse, rat for MOGS 

    Assay Products for MOGS: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MOGS
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MOGS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MOGS 
    Cloud-Clone Corp. CLIAs for MOGS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR004888 Glycoside_hydrolase_63
     IPR008928 6-hairpin_glycosidase-like

    Graphical View of Domain Structure for InterPro Entry Q13724

    ProtoNet protein and cluster: Q13724

    1 Blocks protein domain: IPB004888 Glycoside hydrolase

    UniProtKB/Swiss-Prot: MOGS_HUMAN, Q13724
    Similarity: Belongs to the glycosyl hydrolase 63 family


    MOGS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOGS_HUMAN, Q13724
    Function: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide
    precursor in a highly specific manner
    Catalytic activity: Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide
    Glc(3)Man(9)GlcNAc(2)

         Enzyme Number (IUBMB): EC 3.2.1.1061 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004573mannosyl-oligosaccharide glucosidase activity IEA--
    GO:0015926glucosidase activity TAS7635146
         
    MOGS for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MOGS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MOGS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MOGS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MOGS 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOGS
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate MOGS (see all 14):
    hsa-miR-4324 hsa-miR-181c hsa-miR-130a* hsa-miR-23c hsa-miR-181a hsa-miR-181d hsa-miR-23b hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidMOGS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MOGS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOGS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MOGS
    Sirion Biotech Customized adenovirus for overexpression of MOGS

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MOGS (see all 12)
    OriGene ORF clones in mouse, rat for MOGS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MOGS (NM_006302)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOGS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOGS
    Sirion Biotech Customized lentivirus for stable overexpression of MOGS 
                         Customized lentivirus expression plasmids for stable overexpression of MOGS 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MOGS
    Search LifeMap BioReagents cell lines for MOGS
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOGS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MOGS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    N-Glycan biosynthesis0.52
    WNT ligand biogenesis and trafficking0.77
    Post-translational protein modification0.44
    Signaling by Wnt0.62
    Metabolism of proteins0.35
    2Calnexin/calreticulin cycle
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle0.85
    3Signaling by GPCR
    Signal Transduction0.55
    4Metabolism
    Metabolic pathways0.40
    5Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/7        Reactome Pathways for MOGS (see all 7)
        Signaling by Wnt
    Asparagine N-linked glycosylation
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle
    Signal Transduction
    Metabolism of proteins


    3         Kegg Pathways  (Kegg details for MOGS):
        N-Glycan biosynthesis
    Metabolic pathways
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: MOGS_HUMAN, Q13724
    Pathway: Glycan metabolism; N-glycan degradation


    MOGS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOGS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for MOGS (Q137242, 3 ENSP000002336164) via UniProtKB, MINT, STRING, and/or I2D (see all 63)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHGBP050602, 3MINT-64148 I2D: score=5 
    TIMM44O436153, ENSP000002705384I2D: score=5 STRING: ENSP00000270538
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    PSMD3O432423, ENSP000002646394I2D: score=3 STRING: ENSP00000264639
    ALG5Q9Y6733, ENSP000002398914I2D: score=1 STRING: ENSP00000239891
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0006487protein N-linked glycosylation TAS7635146
    GO:0009311oligosaccharide metabolic process IEA--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--

    MOGS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MOGS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MOGS

    7 Novoseek inferred chemical compound relationships for MOGS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    castanospermine 90.1 9 1832085 (1), 12383251 (1), 1402401 (1), 15893367 (1) (see all 7)
    1-deoxynojirimycin 85.7 10 14718372 (3), 1650361 (1), 9271078 (1), 11401481 (1) (see all 5)
    kifunensine 81.7 1 15893367 (1)
    polysaccharide 60 8 7592804 (2), 9234902 (1), 7635146 (1), 8910335 (1) (see all 7)
    mannose 46.5 1 9647663 (1)
    glucose 43.8 8 1828762 (1), 9363442 (1), 1650361 (1), 7635146 (1) (see all 8)
    histidine 15.2 1 9647663 (1)

    Search CenterWatch for drugs/clinical trials and news about MOGS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MOGS gene (2 alternative transcripts): 
    NM_001146158.1  NM_006302.2  

    Unigene Cluster for MOGS:

    Mannosyl-oligosaccharide glucosidase
    Hs.516119  [show with all ESTs]
    Unigene Representative Sequence: NM_006302
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233616(uc010yrt.2 uc010ffi.3 uc010ffj.3) ENST00000409065
    ENST00000462189(uc010ffh.3) ENST00000448666 ENST00000462443 ENST00000489655
    ENST00000414701 ENST00000486036 ENST00000452063 ENST00000535045(uc010yru.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOGS
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate MOGS (see all 14):
    hsa-miR-4324 hsa-miR-181c hsa-miR-130a* hsa-miR-23c hsa-miR-181a hsa-miR-181d hsa-miR-23b hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidMOGS 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MOGS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOGS
    Clone
    Products:
         
    OriGene clones in human, mouse for MOGS (see all 12)
    OriGene ORF clones in mouse, rat for MOGS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MOGS (NM_006302)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOGS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOGS
    Sirion Biotech Customized lentivirus for stable overexpression of MOGS 
                         Customized lentivirus expression plasmids for stable overexpression of MOGS 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MOGS
    OriGene qSTAR qPCR primer pairs in human, mouse for MOGS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MOGS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOGS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOGS

    Additional mRNA sequence: 

    AK292553.1 AK292719.1 AK304655.1 AK307991.1 AK313355.1 BC002804.2 BC028337.1 BC117250.1 
    BC117252.1 BC143934.1 X87237.1 

    18 DOTS entries:

    DT.100783565  DT.451606  DT.95182363  DT.91770826  DT.100783569  DT.120976867  DT.120976780  DT.91770823 
    DT.102825071  DT.451605  DT.91770813  DT.91990264  DT.95182385  DT.100823662  DT.91846161  DT.95134975 
    DT.95182362  DT.100783572 

    24/134 AceView cDNA sequences (see all 134):

    BM782318 BQ632031 AA368657 BU845915 CD672611 AW137195 BC028337 BE501715 
    BM563651 BU858999 BQ631735 AU131538 BP356961 BU845735 BM920234 BE336935 
    AW137193 AL561337 BE615799 BE727041 BM823966 AL578532 AL543078 W30951 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MOGS (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
    SP1:                    -     -           -     -                                             
    SP2:                                            -                                             
    SP3:                    -     -     -     -     -                                             
    SP4:                    -     -     -           -                                             
    SP5:                                      -     -                                             


    ECgene alternative splicing isoforms for MOGS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MOGS expression in normal human tissues (normalized intensities)      MOGS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACTCTGGC
    MOGS Expression
    About this image


    MOGS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             lung ; pneumocytes   

    See MOGS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MOGS

    SOURCE GeneReport for Unigene cluster: Hs.516119
        SABiosciences Expression via Pathway-Focused PCR Array including MOGS: 
              Glycosylation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MOGS
    OriGene qSTAR qPCR primer pairs in human, mouse for MOGS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MOGS
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOGS
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOGS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOGS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MOGS gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mogs1 , 5 mannosyl-oligosaccharide glucosidase1, 5 83.43(n)1
    86.79(a)1
      6 (35.94 cM)5
    573771  NM_020619.21  NP_065644.21 
     831154965 
    lizard
    (Anolis carolinensis)
    Reptilia MOGS6
    Uncharacterized protein
    52(a)
    1 ↔ 1
    GL344203.1(19304-30311)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.195302 Xenopus laevis transcribed sequence with weak similarity more 75.34(n)    BJ621888.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mogs1 mannosyl-oligosaccharide glucosidase 54.59(n)
    50.12(a)
      567913  NM_001080190.1  NP_001073659.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15971 CG1597 52.43(n)
    47.06(a)
      32073  NM_132479.2  NP_572707.4 
    worm
    (Caenorhabditis elegans)
    Secernentea F13H10.41 Protein F13H10.4 49.29(n)
    45.3(a)
      177998  NM_001129299.1  NP_001122771.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CWH41(YGL027C)4
    CWH411
    Processing alpha glucosidase I, ER type II integral more4
    Cwh41p1
    43.1(n)1
    35.5(a)1
      7(446143-443642)4
    8528571, 4  NP_011488.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GCS11 glucosidase 1 47.26(n)
    41.25(a)
      843070  NM_105416.4  NP_176916.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g09212001 hypothetical protein 48.44(n)
    41.1(a)
      4327748  NM_001051760.2  NP_001045225.2 


    ENSEMBL Gene Tree for MOGS (if available)
    TreeFam Gene Tree for MOGS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MOGS gene
    1 SIMAP similar gene for MOGS using alignment to 5 protein entries:     MOGS_HUMAN (see all proteins):
    GCS1

    MOGS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/191 SNPs in MOGS are shown (see all 191)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0189674
    Type IIb congenital disorder of glycosylation (CDGIIb)4--see VAR_0189672 F L mis40--------
    VAR_0189664
    Type IIb congenital disorder of glycosylation (CDGIIb)4--see VAR_0189662 R T mis40--------
    rs1997140631,2
    --74558954(+) TGCCAC/GATCTG 2 -- ds50010--------
    rs617334701,2
    C,F--74559022(+) GGGCTG/ATCTTC 2 -- ds50013Minor allele frequency- A:0.03NS NA EU 5173
    rs46861,2
    C--74559118(-) CCAAAG/AGAACG 2 -- ds50013Minor allele frequency- A:0.49MN NA 374
    rs1436735451,2
    --74559127(+) GGCCCC/GTCCCT 2 -- ds50010--------
    rs1181560651,2
    C,F--74559201(+) ACCCCC/TGCAGG 2 -- ds50011Minor allele frequency- T:0.02EA 120
    rs1903874941,2
    --74559202(+) CCCCCA/GCAGGA 2 -- ds50010--------
    rs1814706291,2
    --74559292(+) CTGCAC/TTGCAC 2 -- ds50010--------
    rs1857654071,2
    --74559534(+) ATGAGA/GAAGGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MOGS (74688184 - 74692537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MOGS:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv458185CNV Loss19166990
    nsv515851CNV Loss19592680
    dgv4166n71CNV Loss21882294
    dgv1199e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): MOGS

    Locus Specific Mutation Databases (LSDB): MOGS
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MOGS
    DNA2.0 Custom Variant and Variant Library Synthesis for MOGS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601336   
    OMIM disorders: 606056  
    UniProtKB/Swiss-Prot: MOGS_HUMAN, Q13724
  • Type IIb congenital disorder of glycosylation (CDGIIb) [MIM:606056]: Characterized by marked generalized
    hypotonia and hypomotility of the neonate, dysmorphic features, including a prominent occiput, short palpebral
    fissures, retrognathia, high arched palate, generalized edema, and hypoplastic genitalia. Symptoms of the infant
    included hepatomegaly, hypoventilation, feeding problems and seizures. The clinical course was progressive and
    the infant did not survive more than a few months. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 6 diseases for MOGS:    About MalaCards
    congenital disorder of glycosylation    gaucher's disease    hiv type 1    protein s deficiency
    hypotonia    influenza


    MOGS for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for MOGS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congenital disorders 46.9 1 12145188 (1)
    carcinoma 0 1 10706129 (1)

    GeneTests: MOGS
    GeneReviews: MOGS

    Export disorders for MOGS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MOGS gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with MOGS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of glucosidase I from human hippocampus. (PubMed id 7635146)1, 2, 3, 9 Kalz-Fueller B.... Bause E. (1995)
    2. Processing of N-linked carbohydrate chains in a patient with glucosidase I deficiency (CDG type IIb). (PubMed id 12145188)1, 2, 9 Voelker C.... Bause E. (2002)
    3. A novel disorder caused by defective biosynthesis of N-linked oligosaccharides due to glucosidase I deficiency. (PubMed id 10788335)1, 2, 9 De Praeter C.M....Van Coster R.N. (2000)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Localization of the human glucosidase I gene to chromosome 2p12-p13 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids. (PubMed id 8786151)1, 3 Kalz-Fuller B....Schwanitz G. (1996)
    6. (Arg)3 within the N-terminal domain of glucosidase I contains ER targeting information but is not required absolutely for ER localization. (PubMed id 12626409)1, 9 Hardt B....Bause E. (2003)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. SGTA recognizes a noncanonical ubiquitin-like domain i n the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degra dation. (PubMed id 23246001)1 Xu Y....Ye Y. (2012)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7841 HGNC: 24862 AceView: GCS1 Ensembl:ENSG00000115275 euGenes: HUgn7841
    ECgene: MOGS Kegg: 7841 H-InvDB: MOGS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MOGS Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GCS1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MOGS gene:
    Search GeneIP for patents involving MOGS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MOGS  
     OriGene qPCR primer pairs and template standards for MOGS   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MOGS  
     OriGene qSTAR qPCR primer pairs in human, mouse for MOGS   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MOGS   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MOGS   OriGene Custom Protein Services for MOGS  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MOGS
     QIAGEN SeqTarget long-range PCR primers for resequencing MOGS
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOGS
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOGS
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOGS
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOGS
     GenScript Custom Purified and Recombinant Proteins Services for MOGS GenScript cDNA clones with any tag delivered in your preferred vector for MOGS
     GenScript Custom Assay Services for MOGS GenScript Custom Superior Antibodies Services for MOGS
     GenScript Custom overexpressing Cell Line Services for MOGS CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MOGS promoter
     Search Chromatin IP Primers for MOGS
     RT2 qPCR Primer Assay in human, mouse, rat MOGS
     Search GNC Networks for MOGS
     SABiosciences PCR Arrays including human, mouse, rat MOGS
     Search Tocris compounds for MOGS
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MOGS antibodies
     Antibodies for MOGS
     See all of Abcam's Antibodies, Kits and Proteins for MOGS
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MOGS
     Antibodies for MOGS
     ELISAs for MOGS
     CLIAs for MOGS
     Search LifeMap BioReagents cell lines for MOGS
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOGS
     SwitchGear 3'UTR luciferase reporter plasmids for MOGS
     SwitchGear Promoter luciferase reporter plasmids for MOGS
     ThermoFisher Antibodies for MOGS
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOGS
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MOGS
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MOGS
    Customized:
     lentivirus for stable overexpression of MOGS
     lentivirus expression plasmids for stable overexpression of MOGS
     adenovirus for overexpression of MOGS
     LSBio Antibodies in human, mouse, rat for MOGS
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MOGS gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4