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Aliases for MOGS Gene

Aliases for MOGS Gene

  • Mannosyl-Oligosaccharide Glucosidase 2 3 5
  • Processing A-Glucosidase I 2 3 4
  • Glucosidase I 2 3
  • EC 4 58
  • GCS1 3 4
  • CDG2B 3
  • CWH41 3
  • DER7 3

External Ids for MOGS Gene

Previous GeneCards Identifiers for MOGS Gene

  • GC02M074542
  • GC02M074688
  • GC02M074425

Summaries for MOGS Gene

Entrez Gene Summary for MOGS Gene

  • This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for MOGS Gene

MOGS (Mannosyl-Oligosaccharide Glucosidase) is a Protein Coding gene. Diseases associated with MOGS include Congenital Disorder Of Glycosylation, Type Iib and Synchronous Multifocal Osteogenic Sarcoma. Among its related pathways are Protein processing in endoplasmic reticulum and Transport to the Golgi and subsequent modification. GO annotations related to this gene include mannosyl-oligosaccharide glucosidase activity and glucosidase activity.

UniProtKB/Swiss-Prot for MOGS Gene

  • Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.

Gene Wiki entry for MOGS Gene

Additional gene information for MOGS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOGS Gene

Genomics for MOGS Gene

Regulatory Elements for MOGS Gene

Enhancers for MOGS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H074739 1.5 FANTOM5 Ensembl ENCODE 17.1 -275.6 -275607 3.6 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 BRCA1 GTF3C2 FOS DEK ENSG00000273245 MOGS SEMA4F DUSP11 PCGF1 AUP1 TTC31 DGUOK-AS1 CCDC142 M1AP
GH02H074196 1.2 ENCODE 17.1 +266.7 266663 3.9 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 INO80B PCGF1 ENSG00000273245 DUSP11 WBP1 ALMS1 DGUOK-AS1 AUP1 SEMA4F TTC31
GH02H074177 1.1 ENCODE 17.1 +286.9 286894 2.3 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 SP3 SP5 DUSP11 BOLA3-AS1 ENSG00000273245 AUP1 TTC31 DGUOK-AS1 LOC107985899 INO80B MOGS PCGF1
GH02H074289 1 Ensembl ENCODE 17.3 +174.4 174379 2.2 HDGF TRIM22 ZIC2 NFIC NONO BCL11A POLR2A IKZF1 TARDBP NBN ENSG00000270571 MOGS TTC31 DUSP11 AUP1 ENSG00000273245 PCGF1 CCDC142 SLC4A5 MOB1A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MOGS on UCSC Golden Path with GeneCards custom track

Promoters for MOGS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119167 10 1601 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207

Genomic Locations for MOGS Gene

Genomic Locations for MOGS Gene
4,354 bases
Minus strand

Genomic View for MOGS Gene

Genes around MOGS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOGS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOGS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOGS Gene

Proteins for MOGS Gene

  • Protein details for MOGS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mannosyl-oligosaccharide glucosidase
    Protein Accession:
    Secondary Accessions:
    • A8K938
    • F5H6D0
    • Q17RN9
    • Q8TCT5

    Protein attributes for MOGS Gene

    837 amino acids
    Molecular mass:
    91918 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MOGS Gene


neXtProt entry for MOGS Gene

Selected DME Specific Peptides for MOGS Gene


Post-translational modifications for MOGS Gene

Domains & Families for MOGS Gene

Gene Families for MOGS Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 63 family.
  • Belongs to the glycosyl hydrolase 63 family.
genes like me logo Genes that share domains with MOGS: view

Function for MOGS Gene

Molecular function for MOGS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2).
UniProtKB/Swiss-Prot Function:
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.

Enzyme Numbers (IUBMB) for MOGS Gene

Gene Ontology (GO) - Molecular Function for MOGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004573 mannosyl-oligosaccharide glucosidase activity TAS --
GO:0015926 glucosidase activity TAS 7635146
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with MOGS: view
genes like me logo Genes that share phenotypes with MOGS: view

Human Phenotype Ontology for MOGS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MOGS Gene

MGI Knock Outs for MOGS:
  • Mogs tm1.1(KOMP)Vlcg
  • Mogs tm1(KOMP)Vlcg

Animal Model Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for MOGS Gene

Localization for MOGS Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOGS Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOGS gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
plasma membrane 2
lysosome 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MOGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS,IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane TAS,IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with MOGS: view

Pathways & Interactions for MOGS Gene

genes like me logo Genes that share pathways with MOGS: view

UniProtKB/Swiss-Prot Q13724-MOGS_HUMAN

  • Pathway: Glycan metabolism; N-glycan degradation.

Gene Ontology (GO) - Biological Process for MOGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0006487 protein N-linked glycosylation TAS 7635146
GO:0008152 metabolic process IEA --
GO:0009311 oligosaccharide metabolic process IEA --
genes like me logo Genes that share ontologies with MOGS: view

No data available for SIGNOR curated interactions for MOGS Gene

Drugs & Compounds for MOGS Gene

(8) Drugs for MOGS Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-glucose Approved Pharma 0
Water Approved Pharma 0
Castanospermine Experimental Pharma 0

(1) Additional Compounds for MOGS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for MOGS Gene

Compound Action Cas Number
Castanospermine 79831-76-8
genes like me logo Genes that share compounds with MOGS: view

Drug Products

Transcripts for MOGS Gene

Unigene Clusters for MOGS Gene

Mannosyl-oligosaccharide glucosidase:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOGS Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - - -
SP2: -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6: -

Relevant External Links for MOGS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MOGS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOGS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MOGS Gene

This gene is overexpressed in Nasal epithelium (31.0) and Placenta (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MOGS Gene

Protein tissue co-expression partners for MOGS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOGS Gene:


SOURCE GeneReport for Unigene cluster for MOGS Gene:


Evidence on tissue expression from TISSUES for MOGS Gene

  • Nervous system(4.6)
  • Liver(4.5)
  • Kidney(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MOGS Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • digestive
  • immune
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • chin
  • cranial nerve
  • eye
  • eyelid
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • skull
  • chest wall
  • clavicle
  • diaphragm
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • liver
  • pelvis
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • hair
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with MOGS: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MOGS Gene

Orthologs for MOGS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOGS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MOGS 33 34
  • 99.64 (n)
(Canis familiaris)
Mammalia MOGS 33 34
  • 88.98 (n)
(Bos Taurus)
Mammalia MOGS 33 34
  • 86.58 (n)
(Mus musculus)
Mammalia Mogs 33 16 34
  • 83.43 (n)
(Rattus norvegicus)
Mammalia Gcs1 33
  • 82.91 (n)
(Monodelphis domestica)
Mammalia MOGS 34
  • 71 (a)
(Anolis carolinensis)
Reptilia MOGS 34
  • 52 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19530 33
(Danio rerio)
Actinopterygii mogs 33 34
  • 54.1 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1597 33 34
  • 52.29 (n)
(Caenorhabditis elegans)
Secernentea F13H10.4 33 34
  • 45.91 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CWH41 34 36
  • 28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GCS1 33
  • 46.79 (n)
(Oryza sativa)
Liliopsida Os01g0921200 33
  • 48.46 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for MOGS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MOGS Gene

Gene Tree for MOGS (if available)
Gene Tree for MOGS (if available)

Paralogs for MOGS Gene

(1) SIMAP similar genes for MOGS Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MOGS: view

No data available for Paralogs for MOGS Gene

Variants for MOGS Gene

Sequence variations from dbSNP and Humsavar for MOGS Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs121909291 Pathogenic, Type IIb congenital disorder of glycosylation (CDGIIb) [MIM:606056] 74,462,332(-) TGGGA(A/C/G)GGAGC reference, missense
rs121909292 Pathogenic, Type IIb congenital disorder of glycosylation (CDGIIb) [MIM:606056] 74,461,835(-) GAGTC(C/T)TTGCA reference, missense
rs587777323 Pathogenic 74,464,705(+) GCCCT(A/G)CTGCG intron-variant, reference, stop-gained
rs863225089 Likely pathogenic 74,464,919(-) GACCC(A/G)CAGCC reference, missense, utr-variant-5-prime
rs13405869 Likely benign 74,461,757(+) GGGCC(A/G)ACCCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MOGS Gene

Variant ID Type Subtype PubMed ID
nsv582214 CNV loss 21841781
nsv515851 CNV loss 19592680
nsv458185 CNV loss 19166990
esv2759061 CNV loss 17122850

Variation tolerance for MOGS Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOGS Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOGS Gene

Disorders for MOGS Gene

MalaCards: The human disease database

(3) MalaCards diseases for MOGS Gene - From: HGMD, OMIM, ClinVar, Orphanet, Swiss-Prot, and DISEASES

Disorder Aliases PubMed IDs
congenital disorder of glycosylation, type iib
  • mogs-cdg
synchronous multifocal osteogenic sarcoma
  • synchronous multifocal osteosarcoma
multifocal osteogenic sarcoma
  • multifocal osteosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search MOGS in MalaCards View complete list of genes associated with diseases


  • Type IIb congenital disorder of glycosylation (CDGIIb) [MIM:606056]: Characterized by marked generalized hypotonia and hypomotility of the neonate, dysmorphic features, including a prominent occiput, short palpebral fissures, retrognathia, high arched palate, generalized edema, and hypoplastic genitalia. Symptoms of the infant included hepatomegaly, hypoventilation, feeding problems and seizures. The clinical course was progressive and the infant did not survive more than a few months. {ECO:0000269 PubMed:10788335}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MOGS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MOGS: view

No data available for Genatlas for MOGS Gene

Publications for MOGS Gene

  1. Cloning and expression of glucosidase I from human hippocampus. (PMID: 7635146) Kalz-Füller B … Bause E (European journal of biochemistry 1995) 2 3 4 22 60
  2. Processing of N-linked carbohydrate chains in a patient with glucosidase I deficiency (CDG type IIb). (PMID: 12145188) Völker C … Bause E (Glycobiology 2002) 3 4 22 60
  3. A novel disorder caused by defective biosynthesis of N-linked oligosaccharides due to glucosidase I deficiency. (PMID: 10788335) De Praeter CM … Van Coster RN (American journal of human genetics 2000) 3 4 22 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. (Arg)3 within the N-terminal domain of glucosidase I contains ER targeting information but is not required absolutely for ER localization. (PMID: 12626409) Hardt B … Bause E (Glycobiology 2003) 3 22 60

Products for MOGS Gene

Sources for MOGS Gene

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