Aliases for MOGS Gene
External Ids for MOGS Gene
Previous GeneCards Identifiers for MOGS Gene
This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for MOGS Gene
MOGS (Mannosyl-Oligosaccharide Glucosidase) is a Protein Coding gene. Diseases associated with MOGS include Congenital Disorder Of Glycosylation, Type Iib and Gcs1-Cdg. Among its related pathways are Protein processing in endoplasmic reticulum and Transport to the Golgi and subsequent modification. GO annotations related to this gene include mannosyl-oligosaccharide glucosidase activity and glucosidase activity.
UniProtKB/Swiss-Prot for MOGS Gene
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.