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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MOGAT3 Gene

protein-coding   GIFtS: 51
GCID: GC07M100838

Monoacylglycerol O-Acyltransferase 3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Monoacylglycerol O-Acyltransferase 31 2 3     MGAT32 3
Acyl-CoA:Monoacylglycerol Acyltransferase 32 3     hDC72 3
Diacylglycerol Acyltransferase 2-Like Protein 72 3     2-Acylglycerol O-Acyltransferase 32
Diacylglycerol O-Acyltransferase Candidate 72 3     Acyl Coenzyme A:Monoacylglycerol Acyltransferase 32
DC72 3     EC 2.3.1.203
DGAT2L72 3     EC 2.3.1.223

External Ids:    HGNC: 232491   Entrez Gene: 3466062   Ensembl: ENSG000001063847   OMIM: 6101845   UniProtKB: Q86VF53   

Export aliases for MOGAT3 gene to outside databases

Previous GC identifers: GC07M100400 GC07M100432 GC07M100625 GC07M095431


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MOGAT3 Gene:
Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from
2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 (PubMed 12618427)).(supplied by OMIM, Mar 2008)

GeneCards Summary for MOGAT3 Gene: 
MOGAT3 (monoacylglycerol O-acyltransferase 3) is a protein-coding gene. Diseases associated with MOGAT3 include alcoholism, and among its related super-pathways are triacylglycerol biosynthesis and Metabolism. GO annotations related to this gene include diacylglycerol O-acyltransferase activity and 2-acylglycerol O-acyltransferase activity. An important paralog of this gene is DGAT2.

UniProtKB/Swiss-Prot: MOGT3_HUMAN, Q86VF5
Function: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to
catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates.
Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small
intestine by catalyzing the resynthesis of triacylglycerol in enterocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MOGAT3 gene promoter:
         p53   HTF   Olf-1   HNF-4alpha2   NF-kappaB   FOXL1   HNF-4alpha1   NF-kappaB2   Pax-4a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOGAT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MOGAT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOGAT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22

MOGAT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOGAT3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100838:  view genomic region     (about GC identifiers)

Start:
100,838,288 bp from pter      End:
100,844,302 bp from pter
Size:
6,015 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 100,197,397-100,202,689     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MOGT3_HUMAN, Q86VF5 (See protein sequence)
Recommended Name: 2-acylglycerol O-acyltransferase 3  
Size: 341 amino acids; 38730 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=AAD45832.1; Type=Erroneous gene model prediction;
Secondary accessions: Q496A6 Q496A7 Q496A8 Q9UDW7
Alternative splicing: 3 isoforms:  Q86VF5-1   Q86VF5-2   Q86VF5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MOGAT3: NX_Q86VF5

Explore proteomics data for MOGAT3 at MOPED 

MOGAT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

MOGAT3 Protein Expression

REFSEQ proteins: NP_835470.1  
ENSEMBL proteins: 
 ENSP00000223114   ENSP00000403756   ENSP00000368734  

Human Recombinant Protein Products for MOGAT3: 
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Cloud-Clone Corp. Proteins for MOGAT3 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005789endoplasmic reticulum membrane IEA--
GO:0016021integral to membrane IEA--

MOGAT3 for ontologies           About GeneDecksing



MOGAT3 Antibody Products: 
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LSBio Antibodies in human, mouse, rat for MOGAT3 

Assay Products for MOGAT3: 
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Cloud-Clone Corp. ELISAs for MOGAT3 
Cloud-Clone Corp. CLIAs for MOGAT3


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR007130 DAGAT

Graphical View of Domain Structure for InterPro Entry Q86VF5

ProtoNet protein and cluster: Q86VF5

UniProtKB/Swiss-Prot: MOGT3_HUMAN, Q86VF5
Similarity: Belongs to the diacylglycerol acyltransferase family


MOGAT3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: MOGT3_HUMAN, Q86VF5
Function: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to
catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates.
Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small
intestine by catalyzing the resynthesis of triacylglycerol in enterocytes
Catalytic activity: Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol
Catalytic activity: Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol
Biophysicochemical properties: Kinetic parameters: Vmax=9.3 nmol/min/mg enzyme with diacylglycerol as substrate;
Vmax=22.8 nmol/min/mg enzyme with 2-monoacylglycerol as substrate;

     Enzyme Numbers (IUBMB): EC 2.3.1.201 EC 2.3.1.221

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:00038462-acylglycerol O-acyltransferase activity IEA--
GO:0004144diacylglycerol O-acyltransferase activity IEA--
GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
     
MOGAT3 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for MOGAT3:
 Decreased viability with pacli 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for MOGAT3 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MOGAT3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MOGAT3 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MOGAT3 

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidMOGAT3 3' UTR sequence
Inhib. RNA
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Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for MOGAT3
Sirion Biotech Customized adenovirus for overexpression of MOGAT3

Clone
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OriGene clones in human, mouse for MOGAT3 (see all 5)
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GenScript: all cDNA clones in your preferred vector: MOGAT3 (NM_178176)
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOGAT3


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for MOGAT3 About                                                                                                See pathways by source

SuperPathContained pathways About
1CDP-diacylglycerol biosynthesis I
triacylglycerol biosynthesis0.50
Triacylglyceride Synthesis0.36
2Metabolism
Metabolic pathways0.40
3Fat digestion and absorption
Fat digestion and absorption
4Glycerolipid metabolism
Glycerolipid metabolism

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 BioSystems Pathways for MOGAT3
    Triacylglyceride Synthesis
triacylglycerol biosynthesis


3         Kegg Pathways  (Kegg details for MOGAT3):
    Glycerolipid metabolism
Metabolic pathways
Fat digestion and absorption

UniProtKB/Swiss-Prot: MOGT3_HUMAN, Q86VF5
Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis


MOGAT3 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOGAT3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/30 Interacting proteins for MOGAT3 (ENSP000002231144) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

InteractantInteraction Details
GeneCardExternal ID(s)
TBC1D5ENSP000004029354STRING: ENSP00000402935
CELENSP000003611514STRING: ENSP00000361151
DGAT1ENSP000003322584STRING: ENSP00000332258
DGAT2ENSP000002280274STRING: ENSP00000228027
PNLIPENSP000003582234STRING: ENSP00000358223
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006071glycerol metabolic process IEA--
GO:0019432triglyceride biosynthetic process IEA--

MOGAT3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MOGAT3 (MOGT3)

10/1226 HMDB Compounds for MOGAT3 (see all 1226)    About this table
CompoundSynonyms CAS #PubMed Ids
DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
(2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
(2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
(2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
(2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
(2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
2-Arachidonylglycerol2-Arachidonyl glycerol;(all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid (see all 21)53847-30-6--
2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--

Search CenterWatch for drugs/clinical trials and news about MOGAT3 / MOGT3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MOGAT3 gene: 
NM_178176.2  

Unigene Cluster for MOGAT3:

Monoacylglycerol O-acyltransferase 3
Hs.512217  [show with all ESTs]
Unigene Representative Sequence: AY229854
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000223114(uc003uyc.3 uc010lhr.3) ENST00000440203 ENST00000379423

miRNA
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Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for MOGAT3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOGAT3
Clone
Products:
     
OriGene clones in human, mouse for MOGAT3 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: MOGAT3 (NM_178176)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOGAT3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOGAT3
Sirion Biotech Customized lentivirus for stable overexpression of MOGAT3 
                     Customized lentivirus expression plasmids for stable overexpression of MOGAT3 
Primer
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OriGene qPCR primer pairs and template standards for MOGAT3
OriGene qSTAR qPCR primer pairs in human, mouse for MOGAT3
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MOGAT3
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOGAT3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOGAT3

Additional mRNA sequence: 

AY229854.1 AY358200.1 BC100953.1 BC100954.1 BC100955.1 

2 DOTS entries:

DT.99941420  DT.40273699 

6 AceView cDNA sequences:

AY358200 AI207424 AY229854 BE042458 NM_178176 CA432791 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MOGAT3    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:                                    
SP2:                                    
SP3:                          -         


ECgene alternative splicing isoforms for MOGAT3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MOGAT3 expression in normal human tissues (normalized intensities)      MOGAT3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCTCCAATAA
MOGAT3 Expression
About this image


MOGAT3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/18 selected tissues (see all 18) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 2 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
         lung ; macrophages   
 
 Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
         rectum ; glandular cells   
 
 Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
         small intestine ; glandular cells   
 
 Lung (Respiratory System)    fully expand to see all 2 entries
         bronchus ; respiratory epithelial cells   
 
 Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
         placenta ; decidual cells   

See MOGAT3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MOGAT3

SOURCE GeneReport for Unigene cluster: Hs.512217

UniProtKB/Swiss-Prot: MOGT3_HUMAN, Q86VF5
Tissue specificity: Selectively expressed in the digestive system. Highly expressed in the ileum, and at lower
level in jejunum, duodenum, colon, cecum and the rectum. Not expressed in the stomach and the esophagus and
trachea. Expressed at very low level in liver

    SABiosciences Custom PCR Arrays for MOGAT3
Primer
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOGAT3
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOGAT3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOGAT3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOGAT3 gene from 5/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia MOGAT31 monoacylglycerol O-acyltransferase 3 79.41(n)
73.7(a)
  608245  XM_845212.2  XP_850305.2 
zebrafish
(Danio rerio)
Actinopterygii LOC5651161 diacylglycerol O-acyltransferase 2-like 55.66(n)
53.77(a)
  565116  XM_688413.4  XP_693505.1 
fruit fly
(Drosophila melanogaster)
Insecta CG19416
CG19426
(see all 3)
--
35(a)
35(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
2R(3597379-3599494)
2R(3600128-3601695)
worm
(Caenorhabditis elegans)
Secernentea Y53G8B.26
dgat-26
(see all 4)
Protein F59A1.10
(see all 4)
39(a)
37(a)
(see all 4)
many ↔ many
many ↔ many
(see all 4)
III(3101230-3103957)
V(17660304-17661811)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DGA16
Diacylglycerol acyltransferase, catalyzes the term...
28(a)
1 → many
XV(794076-795332)


ENSEMBL Gene Tree for MOGAT3 (if available)
TreeFam Gene Tree for MOGAT3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MOGAT3 gene
DGAT22  MOGAT12  DGAT2L62  AWAT22  AWAT12  MOGAT22  
6 SIMAP similar genes for MOGAT3 using alignment to 1 protein entry:     MOGT3_HUMAN:
DGAT2    DGAT2L6    AWAT2    AWAT1    MOGAT1    MOGAT2

MOGAT3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/164 SNPs in MOGAT3 are shown (see all 164)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1930578941,2
--100838528(+) TCTCGC/TTCTGT 1 -- int10--------
rs20793341,2
C,F--100838569(+) CGGCTG/CACTGC 1 -- int12Minor allele frequency- C:0.50NA CSA 4
rs132408391,2
C,F,A--100838732(+) CTCAGT/GTGATC 1 -- int14Minor allele frequency- G:0.43NA CSA 7
rs1855770961,2
--100838750(+) CTCGGC/GTTCCC 1 -- int10--------
rs1136466171,2
C,F--100838798(+) GCCTAG/CTACAG 1 -- int11Minor allele frequency- C:0.50WA 2
rs604728731,2
C--100838815(+) TTTTT-/T/T   
   TTTTT
GAGAT
2 -- int1 cds12NA 4
rs1904846311,2
--100839027(+) TGAAGC/TCTCAC 1 -- ut310--------
rs1168159111,2
C,F--100839202(+) CAGGGG/ACTCAG 1 -- ut311Minor allele frequency- A:0.03WA 118
rs1385320051,2
C--100839253(+) GGAAGC/TGGGGA 2 T A mis10--------
rs2010455961,2
--100839260(+) GGGACC/GCCACA 2 G syn10--------

HapMap Linkage Disequilibrium report for MOGAT3 (100838288 - 100844302 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for MOGAT3:    About this table     
Variant IDTypeSubtypePubMed ID
esv2734888CNV Deletion23290073
esv2422376CNV Duplication17116639
esv2422326CNV Duplication17116639
nsv831075CNV Loss17160897
nsv831076CNV Loss17160897
dgv7409n71CNV Loss21882294
dgv7410n71CNV Loss21882294
esv2752134CNV Gain17911159


Human Gene Mutation Database (HGMD): MOGAT3
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 610184    OMIM disorders: --

2 diseases for MOGAT3:    About MalaCards
alcoholism    


MOGAT3 for disorders           About GeneDecksing


Export disorders for MOGAT3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MOGAT3 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with MOGAT3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption. (PubMed id 12618427)1, 2, 3, 9 Cheng D.... Feder J.N. (2003)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PubMed id 14970677)1, 3 Winter A....Fries R. (2003)
  4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  7. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PubMed id 12486725)6 Kurz M....Kramer W. (2003)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  9. Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
  10. Catalytic properties of MGAT3, a putative triacylgycerol synthase. (PubMed id 17170429)9 Cao J....Shi Y. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 346606 HGNC: 23249 AceView: MOGAT3 Ensembl:ENSG00000106384 euGenes: HUgn346606
ECgene: MOGAT3 Kegg: 346606 H-InvDB: MOGAT3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MOGAT3 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MOGAT3 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MOGAT3 gene:
Search GeneIP for patents involving MOGAT3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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