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Aliases for MOGAT3 Gene

Aliases for MOGAT3 Gene

  • Monoacylglycerol O-Acyltransferase 3 2 3 4 5
  • Diacylglycerol Acyltransferase 2-Like Protein 7 3 4
  • Diacylglycerol O-Acyltransferase Candidate 7 3 4
  • Acyl-CoA:Monoacylglycerol Acyltransferase 3 3 4
  • MGAT3 3 4
  • DC7 3 4
  • Acyl Coenzyme A:Monoacylglycerol Acyltransferase 3 3
  • EC 2.3.1.20 4
  • EC 2.3.1.22 4
  • DGAT2L7 4
  • DGAT2L2 3
  • HDC7 4

External Ids for MOGAT3 Gene

Previous GeneCards Identifiers for MOGAT3 Gene

  • GC07M100400
  • GC07M100432
  • GC07M100625
  • GC07M100838
  • GC07M095431

Summaries for MOGAT3 Gene

Entrez Gene Summary for MOGAT3 Gene

  • Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MOGAT3 Gene

MOGAT3 (Monoacylglycerol O-Acyltransferase 3) is a Protein Coding gene. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and diacylglycerol O-acyltransferase activity. An important paralog of this gene is MOGAT2.

UniProtKB/Swiss-Prot for MOGAT3 Gene

  • Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOGAT3 Gene

Genomics for MOGAT3 Gene

Regulatory Elements for MOGAT3 Gene

Promoters for MOGAT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MOGAT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MOGAT3 Gene

Chromosome:
7
Start:
101,195,007 bp from pter
End:
101,201,060 bp from pter
Size:
6,054 bases
Orientation:
Minus strand

Genomic View for MOGAT3 Gene

Genes around MOGAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOGAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOGAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOGAT3 Gene

Proteins for MOGAT3 Gene

  • Protein details for MOGAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VF5-MOGT3_HUMAN
    Recommended name:
    2-acylglycerol O-acyltransferase 3
    Protein Accession:
    Q86VF5
    Secondary Accessions:
    • Q496A6
    • Q496A7
    • Q496A8
    • Q9UDW7

    Protein attributes for MOGAT3 Gene

    Size:
    341 amino acids
    Molecular mass:
    38730 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD45832.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MOGAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOGAT3 Gene

Proteomics data for MOGAT3 Gene at MOPED

Post-translational modifications for MOGAT3 Gene

Other Protein References for MOGAT3 Gene

No data available for DME Specific Peptides for MOGAT3 Gene

Domains & Families for MOGAT3 Gene

Gene Families for MOGAT3 Gene

Protein Domains for MOGAT3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MOGAT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VF5

UniProtKB/Swiss-Prot:

MOGT3_HUMAN :
  • Belongs to the diacylglycerol acyltransferase family.
Family:
  • Belongs to the diacylglycerol acyltransferase family.
genes like me logo Genes that share domains with MOGAT3: view

Function for MOGAT3 Gene

Molecular function for MOGAT3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Vmax=9.3 nmol/min/mg enzyme with diacylglycerol as substrate {ECO:0000269 PubMed:12618427}; Vmax=22.8 nmol/min/mg enzyme with 2-monoacylglycerol as substrate {ECO:0000269 PubMed:12618427};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes.

Enzyme Numbers (IUBMB) for MOGAT3 Gene

genes like me logo Genes that share phenotypes with MOGAT3: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MOGAT3 Gene

Localization for MOGAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOGAT3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOGAT3 Gene COMPARTMENTS Subcellular localization image for MOGAT3 gene
Compartment Confidence
endoplasmic reticulum 3
mitochondrion 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for MOGAT3 Gene

Pathways & Interactions for MOGAT3 Gene

genes like me logo Genes that share pathways with MOGAT3: view

UniProtKB/Swiss-Prot Q86VF5-MOGT3_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis.

Interacting Proteins for MOGAT3 Gene

Gene Ontology (GO) - Biological Process for MOGAT3 Gene

None

No data available for SIGNOR curated interactions for MOGAT3 Gene

Drugs & Compounds for MOGAT3 Gene

(2) Drugs for MOGAT3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(101) Additional Compounds for MOGAT3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with MOGAT3: view

Transcripts for MOGAT3 Gene

mRNA/cDNA for MOGAT3 Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MOGAT3 Gene

Monoacylglycerol O-acyltransferase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOGAT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2:
SP3: -

Relevant External Links for MOGAT3 Gene

GeneLoc Exon Structure for
MOGAT3
ECgene alternative splicing isoforms for
MOGAT3

Expression for MOGAT3 Gene

mRNA expression in normal human tissues for MOGAT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOGAT3 Gene

This gene is overexpressed in Colon - Transverse (x19.8), Small Intestine - Terminal Ileum (x16.2), and Liver (x13.8).

SOURCE GeneReport for Unigene cluster for MOGAT3 Gene Hs.512217

mRNA Expression by UniProt/SwissProt for MOGAT3 Gene

Q86VF5-MOGT3_HUMAN
Tissue specificity: Selectively expressed in the digestive system. Highly expressed in the ileum, and at lower level in jejunum, duodenum, colon, cecum and the rectum. Not expressed in the stomach and the esophagus and trachea. Expressed at very low level in liver.
genes like me logo Genes that share expression patterns with MOGAT3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MOGAT3 Gene

Orthologs for MOGAT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MOGAT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC618076 35
  • 78.69 (n)
  • 72.43 (a)
-- 36
  • 67 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MOGAT3 35
  • 79.41 (n)
  • 73.7 (a)
MOGAT3 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MOGAT3 35
  • 98.83 (n)
  • 98.83 (a)
MOGAT3 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MOGAT3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MOGAT3 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 44 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia awat1 35
  • 55.35 (n)
  • 50.78 (a)
zebrafish
(Danio rerio)
Actinopterygii mogat3b 35
  • 55.66 (n)
  • 53.77 (a)
atp6v1e1a 36
  • 51 (a)
OneToOne
Species with no ortholog for MOGAT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOGAT3 Gene

ENSEMBL:
Gene Tree for MOGAT3 (if available)
TreeFam:
Gene Tree for MOGAT3 (if available)

Paralogs for MOGAT3 Gene

Paralogs for MOGAT3 Gene

(6) SIMAP similar genes for MOGAT3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOGAT3: view

Variants for MOGAT3 Gene

Sequence variations from dbSNP and Humsavar for MOGAT3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1004242 -- 101,198,004(-) CCCTA(A/G)GCTCC intron-variant
rs2158612 -- 101,198,108(+) CCC(A/C)TGCAG intron-variant
rs3735337 -- 101,198,582(-) TGACC(A/T)GATGT intron-variant
rs3832504 -- 101,198,547(-) CCCCC(-/C)ATAAT intron-variant
rs3071591 -- 101,202,078(+) GTGGC(-/GAGG/GAGGC)CCCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MOGAT3 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv831075 CNV Loss 17160897
esv2422376 CNV Duplication 17116639
dgv7409n71 CNV Loss 21882294
esv2752134 CNV Gain 17911159
nsv831076 CNV Loss 17160897
dgv7410n71 CNV Loss 21882294
esv2422326 CNV Duplication 17116639

Variation tolerance for MOGAT3 Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOGAT3 Gene

HapMap Linkage Disequilibrium report
MOGAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOGAT3 Gene

Disorders for MOGAT3 Gene

Relevant External Links for MOGAT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOGAT3

No disorders were found for MOGAT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOGAT3 Gene

Publications for MOGAT3 Gene

  1. Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption. (PMID: 12618427) Cheng D. … Feder J.N. (J. Biol. Chem. 2003) 2 3 4 23 67
  2. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A. … Fries R. (Cytogenet. Genome Res. 2003) 2 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Comparative genomics and proteomics of vertebrate diacylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT). (PMID: 20374941) Holmes R.S. (Comp. Biochem. Physiol. Part D Genomics Proteomics 2010) 23
  5. Catalytic properties of MGAT3, a putative triacylgycerol synthase. (PMID: 17170429) Cao J. … Shi Y. (J. Lipid Res. 2007) 23

Products for MOGAT3 Gene

Sources for MOGAT3 Gene

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