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Aliases for MOGAT3 Gene

Aliases for MOGAT3 Gene

  • Monoacylglycerol O-Acyltransferase 3 2 3 4
  • MGAT3 3 4 6
  • Diacylglycerol Acyltransferase 2-Like Protein 7 3 4
  • Diacylglycerol O-Acyltransferase Candidate 7 3 4
  • Acyl-CoA:Monoacylglycerol Acyltransferase 3 3 4
  • DGAT2L7 3 4
  • DC7 3 4
  • Acyl Coenzyme A:Monoacylglycerol Acyltransferase 3 3
  • 2-Acylglycerol O-Acyltransferase 3 3
  • EC 2.3.1.20 4
  • EC 2.3.1.22 4
  • HDC7 4

External Ids for MOGAT3 Gene

Summaries for MOGAT3 Gene

Entrez Gene Summary for MOGAT3 Gene

  • Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MOGAT3 Gene

MOGAT3 (Monoacylglycerol O-Acyltransferase 3) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include 2-acylglycerol O-acyltransferase activity and diacylglycerol O-acyltransferase activity. An important paralog of this gene is MOGAT2.

UniProtKB/Swiss-Prot for MOGAT3 Gene

  • Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOGAT3 Gene

Genomics for MOGAT3 Gene

Genomic Location for MOGAT3 Gene

Start:
101,195,007 bp from pter
End:
101,201,021 bp from pter
Size:
6,015 bases
Orientation:
Minus strand

Genomic View for MOGAT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MOGAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOGAT3 Gene

Regulatory Elements for MOGAT3 Gene

Proteins for MOGAT3 Gene

  • Protein details for MOGAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VF5-MOGT3_HUMAN
    Recommended name:
    2-acylglycerol O-acyltransferase 3
    Protein Accession:
    Q86VF5
    Secondary Accessions:
    • Q496A6
    • Q496A7
    • Q496A8
    • Q9UDW7

    Protein attributes for MOGAT3 Gene

    Size:
    341 amino acids
    Molecular mass:
    38730 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD45832.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MOGAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOGAT3 Gene

Proteomics data for MOGAT3 Gene at MOPED

Post-translational modifications for MOGAT3 Gene

Other Protein References for MOGAT3 Gene

No data available for DME Specific Peptides for MOGAT3 Gene

Domains for MOGAT3 Gene

Protein Domains for MOGAT3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MOGAT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VF5

UniProtKB/Swiss-Prot:

MOGT3_HUMAN
Family:
  • Belongs to the diacylglycerol acyltransferase family.:
    • Q86VF5
genes like me logo Genes that share domains with MOGAT3: view

No data available for Gene Families for MOGAT3 Gene

Function for MOGAT3 Gene

Molecular function for MOGAT3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: Vmax=9.3 nmol/min/mg enzyme with diacylglycerol as substrate {ECO:0000269 PubMed:12618427}; Vmax=22.8 nmol/min/mg enzyme with 2-monoacylglycerol as substrate {ECO:0000269 PubMed:12618427};
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
UniProtKB/Swiss-Prot Function: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes.

Enzyme Numbers (IUBMB) for MOGAT3 Gene

Gene Ontology (GO) - Molecular Function for MOGAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003846 2-acylglycerol O-acyltransferase activity IEA --
GO:0004144 diacylglycerol O-acyltransferase activity IEA --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
genes like me logo Genes that share ontologies with MOGAT3: view

Phenotypes for MOGAT3 Gene

GenomeRNAi human phenotypes for MOGAT3:
genes like me logo Genes that share phenotypes with MOGAT3: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MOGAT3 Gene

Localization for MOGAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOGAT3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOGAT3 Gene COMPARTMENTS Subcellular localization image for MOGAT3 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MOGAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MOGAT3: view

Pathways for MOGAT3 Gene

genes like me logo Genes that share pathways with MOGAT3: view

UniProtKB/Swiss-Prot Q86VF5-MOGT3_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis

Interacting Proteins for MOGAT3 Gene

Gene Ontology (GO) - Biological Process for MOGAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006071 glycerol metabolic process IEA --
GO:0019432 triglyceride biosynthetic process IEA --
genes like me logo Genes that share ontologies with MOGAT3: view

Compounds for MOGAT3 Gene

(1226) HMDB Compounds for MOGAT3 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with MOGAT3: view

Transcripts for MOGAT3 Gene

mRNA/cDNA for MOGAT3 Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MOGAT3 Gene

Monoacylglycerol O-acyltransferase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOGAT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2:
SP3: -

Relevant External Links for MOGAT3 Gene

GeneLoc Exon Structure for
MOGAT3
ECgene alternative splicing isoforms for
MOGAT3

Expression for MOGAT3 Gene

mRNA expression in normal human tissues for MOGAT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOGAT3 Gene

This gene is overexpressed in Colon - Transverse (19.8), Small Intestine - Terminal Ileum (16.2), and Liver (13.8).

SOURCE GeneReport for Unigene cluster for MOGAT3 Gene Hs.512217

mRNA Expression by UniProt/SwissProt for MOGAT3 Gene

Q86VF5-MOGT3_HUMAN
Tissue specificity: Selectively expressed in the digestive system. Highly expressed in the ileum, and at lower level in jejunum, duodenum, colon, cecum and the rectum. Not expressed in the stomach and the esophagus and trachea. Expressed at very low level in liver.
genes like me logo Genes that share expressions with MOGAT3: view

No data available for Protein expression for MOGAT3 Gene

Orthologs for MOGAT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MOGAT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOGAT3 35
  • 98.83 (n)
  • 98.83 (a)
MOGAT3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
LOC618076 35
  • 78.69 (n)
  • 72.43 (a)
dog
(Canis familiaris)
Mammalia MOGAT3 35
  • 79.41 (n)
  • 73.7 (a)
MOGAT3 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MOGAT3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MOGAT3 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 44 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia awat1 35
  • 55.35 (n)
  • 50.78 (a)
zebrafish
(Danio rerio)
Actinopterygii atp6v1e1a 36
  • 51 (a)
OneToOne
mogat3b 35
  • 55.66 (n)
  • 53.77 (a)
Species with no ortholog for MOGAT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOGAT3 Gene

ENSEMBL:
Gene Tree for MOGAT3 (if available)
TreeFam:
Gene Tree for MOGAT3 (if available)

Paralogs for MOGAT3 Gene

Paralogs for MOGAT3 Gene

Selected SIMAP similar genes for MOGAT3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOGAT3: view

Variants for MOGAT3 Gene

Sequence variations from dbSNP and Humsavar for MOGAT3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1004242 -- 101,198,004(-) CCCTA(A/G)GCTCC intron-variant
rs2079334 -- 101,195,288(+) CGGCT(C/G)ACTGC downstream-variant-500B
rs2158612 -- 101,198,108(+) CCC(A/C)TGCAG intron-variant
rs3071591 -- 101,202,078(+) GTGGC(-/GAGG/GAGGC)CCCAA upstream-variant-2KB
rs3735337 -- 101,198,582(-) TGACC(A/T)GATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOGAT3 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv831075 CNV Loss 17160897
esv2422376 CNV Duplication 17116639
dgv7409n71 CNV Loss 21882294
esv2752134 CNV Gain 17911159
nsv831076 CNV Loss 17160897
dgv7410n71 CNV Loss 21882294
esv2422326 CNV Duplication 17116639

Relevant External Links for MOGAT3 Gene

HapMap Linkage Disequilibrium report
MOGAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOGAT3 Gene

Disorders for MOGAT3 Gene

No disorders were found for MOGAT3 Gene.

No data available for UniProtKB/Swiss-Prot for MOGAT3 Gene

Publications for MOGAT3 Gene

  1. Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption. (PMID: 12618427) Cheng D. … Feder J.N. (J. Biol. Chem. 2003) 2 3 4 23
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A. … Fries R. (Cytogenet. Genome Res. 2003) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MOGAT3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MOGAT3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MOGAT3
    • Block miRNA regulation of MOGAT3 using miScript Target Protectors

    Sources for MOGAT3 Gene

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