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Aliases for MOGAT2 Gene

Aliases for MOGAT2 Gene

  • Monoacylglycerol O-Acyltransferase 2 2 3 4
  • MGAT2 3 4 6
  • Diacylglycerol Acyltransferase 2-Like Protein 5 3 4
  • Diacylglycerol O-Acyltransferase Candidate 5 3 4
  • Acyl-CoA:Monoacylglycerol Acyltransferase 2 3 4
  • DGAT2L5 3 4
  • HMGAT2 3 4
  • HDC5 3 4
  • Acyl CoA:Monoacylglycerol Acyltransferase 2 3
  • 2-Acylglycerol O-Acyltransferase 2 3
  • EC 2.3.1.22 4
  • EC 2.3.1 64
  • DC5 4

External Ids for MOGAT2 Gene

Summaries for MOGAT2 Gene

Entrez Gene Summary for MOGAT2 Gene

  • Dietary fat absorption from the small intestine is facilitated by acyl-CoA:monoacylglycerol transferase (MOGAT; EC 2.3.1.22) and acyl-CoA:diacylglycerol acyltransferase (DGAT; see MIM 604900) activities. MOGAT catalyzes the joining of monoacylglycerol and fatty acyl-CoAs to form diacylglycerol (Yen and Farese, 2003 [PubMed 12621063]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MOGAT2 Gene

MOGAT2 (Monoacylglycerol O-Acyltransferase 2) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include acetyltransferase activity and 2-acylglycerol O-acyltransferase activity. An important paralog of this gene is MOGAT1.

UniProtKB/Swiss-Prot for MOGAT2 Gene

  • Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.

Gene Wiki entry for MOGAT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOGAT2 Gene

Genomics for MOGAT2 Gene

Genomic Location for MOGAT2 Gene

Start:
75,717,819 bp from pter
End:
75,732,958 bp from pter
Size:
15,140 bases
Orientation:
Plus strand

Genomic View for MOGAT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MOGAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOGAT2 Gene

Regulatory Elements for MOGAT2 Gene

Proteins for MOGAT2 Gene

  • Protein details for MOGAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SYC2-MOGT2_HUMAN
    Recommended name:
    2-acylglycerol O-acyltransferase 2
    Protein Accession:
    Q3SYC2
    Secondary Accessions:
    • A8K7I3
    • Q3SYC1
    • Q6ZQZ2
    • Q86UH6
    • Q9H630

    Protein attributes for MOGAT2 Gene

    Size:
    334 amino acids
    Molecular mass:
    38196 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MOGAT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOGAT2 Gene

Proteomics data for MOGAT2 Gene at MOPED

Selected DME Specific Peptides for MOGAT2 Gene

Post-translational modifications for MOGAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MOGAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for MOGAT2 Gene

Protein Domains for MOGAT2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MOGT2_HUMAN
Family:
  • Belongs to the diacylglycerol acyltransferase family.:
    • Q3SYC2
genes like me logo Genes that share domains with MOGAT2: view

No data available for Gene Families for MOGAT2 Gene

Function for MOGAT2 Gene

Molecular function for MOGAT2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=45 uM for sn-1-monooleoylglycerol {ECO:0000269 PubMed:12621063};
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by oleic acid and sphingosine, while it is stimulated by phosphatidylcholine, phosphatidylserine and phosphatidic acid.
UniProtKB/Swiss-Prot Function: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.

Enzyme Numbers (IUBMB) for MOGAT2 Gene

Gene Ontology (GO) - Molecular Function for MOGAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003846 2-acylglycerol O-acyltransferase activity IEA --
GO:0016407 acetyltransferase activity IEA --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
genes like me logo Genes that share ontologies with MOGAT2: view
genes like me logo Genes that share phenotypes with MOGAT2: view

Animal Models for MOGAT2 Gene

MGI Knock Outs for MOGAT2:

miRNA for MOGAT2 Gene

miRTarBase miRNAs that target MOGAT2

No data available for Transcription Factor Targeting and HOMER Transcription for MOGAT2 Gene

Localization for MOGAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOGAT2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOGAT2 Gene COMPARTMENTS Subcellular localization image for MOGAT2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MOGAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 14966132
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MOGAT2: view

Pathways for MOGAT2 Gene

genes like me logo Genes that share pathways with MOGAT2: view

UniProtKB/Swiss-Prot Q3SYC2-MOGT2_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis

Gene Ontology (GO) - Biological Process for MOGAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006071 glycerol metabolic process IEA --
GO:0006629 lipid metabolic process --
GO:0006651 diacylglycerol biosynthetic process IEA --
GO:0019432 triglyceride biosynthetic process IEA --
GO:0050892 intestinal absorption IEA --
genes like me logo Genes that share ontologies with MOGAT2: view

Compounds for MOGAT2 Gene

(2438) HMDB Compounds for MOGAT2 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with MOGAT2: view

Transcripts for MOGAT2 Gene

Unigene Clusters for MOGAT2 Gene

Monoacylglycerol O-acyltransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOGAT2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for MOGAT2 Gene

GeneLoc Exon Structure for
MOGAT2
ECgene alternative splicing isoforms for
MOGAT2

Expression for MOGAT2 Gene

mRNA expression in normal human tissues for MOGAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOGAT2 Gene

This gene is overexpressed in Liver (23.5), Colon - Transverse (13.1), and Small Intestine - Terminal Ileum (12.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MOGAT2 Gene

SOURCE GeneReport for Unigene cluster for MOGAT2 Gene Hs.288568

mRNA Expression by UniProt/SwissProt for MOGAT2 Gene

Q3SYC2-MOGT2_HUMAN
Tissue specificity: Highly expressed in liver, small intestine, colon, stomach and kidney.
genes like me logo Genes that share expressions with MOGAT2: view

Orthologs for MOGAT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOGAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOGAT2 36
  • 99.5 (n)
  • 99.7 (a)
MOGAT2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 70 (a)
OneToMany
-- 37
  • 74 (a)
OneToMany
-- 37
  • 70 (a)
OneToMany
MOGAT2 36
  • 77.11 (n)
  • 66.87 (a)
MOGAT2 37
  • 73 (a)
OneToMany
MOGAT2 37
  • 67 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MOGAT2 36
  • 83.73 (n)
  • 82.04 (a)
MOGAT2 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mogat2 36
  • 82.34 (n)
  • 81.14 (a)
Mogat2 16
Mogat2 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 73 (a)
OneToMany
-- 37
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MOGAT2 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mogat2 36
  • 81.84 (n)
  • 80.84 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 70 (a)
OneToMany
-- 37
  • 63 (a)
OneToMany
MOGAT2 36
  • 69.08 (n)
  • 69.88 (a)
lizard
(Anolis carolinensis)
Reptilia MOGAT2 37
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mogat1 36
  • 64.66 (n)
  • 63.66 (a)
zebrafish
(Danio rerio)
Actinopterygii mogat2 36
  • 63.75 (n)
  • 65.74 (a)
mogat2 37
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005949 36
  • 53.54 (n)
  • 45.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1941 37
  • 35 (a)
ManyToMany
CG1942 36
  • 49.22 (n)
  • 41.69 (a)
CG1942 37
  • 37 (a)
ManyToMany
CG1946 37
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dgat-2 37
  • 43 (a)
ManyToMany
dgtr-1 36
  • 49.24 (n)
  • 45.9 (a)
dgtr-1 37
  • 42 (a)
ManyToMany
K07B1.4 37
  • 39 (a)
ManyToMany
Y53G8B.2 37
  • 42 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DGA1 37
  • 31 (a)
OneToMany
DGA1 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 51 (a)
OneToMany
Species with no ortholog for MOGAT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOGAT2 Gene

ENSEMBL:
Gene Tree for MOGAT2 (if available)
TreeFam:
Gene Tree for MOGAT2 (if available)

Paralogs for MOGAT2 Gene

Paralogs for MOGAT2 Gene

Selected SIMAP similar genes for MOGAT2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOGAT2: view

Variants for MOGAT2 Gene

Sequence variations from dbSNP and Humsavar for MOGAT2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs473013 -- 75,716,982(-) tgaga(A/T)ctcat upstream-variant-2KB
rs473791 -- 75,716,939(-) caaag(A/T)cttcc upstream-variant-2KB
rs519091 -- 75,725,003(-) aattt(G/T)tcatc intron-variant
rs543886 -- 75,724,380(-) TCTGT(A/G)CTAAC intron-variant
rs554202 - 75,717,913(+) TGTTT(A/G)TGCCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MOGAT2 Gene

Variant ID Type Subtype PubMed ID
nsv897924 CNV Gain 21882294
esv1010460 CNV Insertion 20482838

Relevant External Links for MOGAT2 Gene

HapMap Linkage Disequilibrium report
MOGAT2

Disorders for MOGAT2 Gene

No disorders were found for MOGAT2 Gene.

No data available for UniProtKB/Swiss-Prot for MOGAT2 Gene

Publications for MOGAT2 Gene

  1. MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine. (PMID: 12621063) Yen C.-L.E. … Farese R.V. Jr. (J. Biol. Chem. 2003) 3 4
  2. Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity. (PMID: 12824082) Lockwood J.F. … Shi Y. (Am. J. Physiol. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A. … Fries R. (Cytogenet. Genome Res. 2003) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MOGAT2 Gene

Sources for MOGAT2 Gene

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