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MOGAT2 Gene

protein-coding   GIFtS: 55
GCID: GC11P075428

Monoacylglycerol O-Acyltransferase 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Monoacylglycerol O-Acyltransferase 21 2 3     hMGAT22 3
MGAT22 3 5     2-Acylglycerol O-Acyltransferase 22
Acyl-CoA:Monoacylglycerol Acyltransferase 22 3     Acyl CoA:Monoacylglycerol Acyltransferase 22
Diacylglycerol Acyltransferase 2-Like Protein 52 3     DC53
Diacylglycerol O-Acyltransferase Candidate 52 3     EC 2.3.1.223
DGAT2L52 3     EC 2.3.18
hDC52 3     

External Ids:    HGNC: 232481   Entrez Gene: 801682   Ensembl: ENSG000001663917   OMIM: 6102705   UniProtKB: Q3SYC23   

Export aliases for MOGAT2 gene to outside databases

Previous GC identifers: GC11P075156 GC11P075106 GC11P071726


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MOGAT2 Gene:
Dietary fat absorption from the small intestine is facilitated by acyl-CoA:monoacylglycerol transferase (MOGAT; EC
2.3.1.22) and acyl-CoA:diacylglycerol acyltransferase (DGAT; see MIM 604900) activities. MOGAT catalyzes the
joining of monoacylglycerol and fatty acyl-CoAs to form diacylglycerol (Yen and Farese, 2003 (PubMed
12621063)).(supplied by OMIM, Mar 2008)

GeneCards Summary for MOGAT2 Gene:
MOGAT2 (monoacylglycerol O-acyltransferase 2) is a protein-coding gene. GO annotations related to this gene include acetyltransferase activity and 2-acylglycerol O-acyltransferase activity. An important paralog of this gene is MOGAT3.

UniProtKB/Swiss-Prot: MOGT2_HUMAN, Q3SYC2
Function: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference
toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a
central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol
in enterocytes. May play a role in diet-induced obesity

Gene Wiki entry for MOGAT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MOGAT2 gene promoter:
         NF-1/L   NF-1   AML1a   ATF-2   Nkx5-1   PPAR-gamma1   GATA-6   PPAR-gamma2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOGAT2 promoter sequence
   Search Chromatin IP Primers for MOGAT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MOGAT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5   Ensembl cytogenetic band:  11q13.5   HGNC cytogenetic band: 11q13.5

MOGAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOGAT2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P075428:  view genomic region     (about GC identifiers)

Start:
75,428,864 bp from pter      End:
75,444,003 bp from pter
Size:
15,140 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MOGT2_HUMAN, Q3SYC2 (See protein sequence)
Recommended Name: 2-acylglycerol O-acyltransferase 2  
Size: 334 amino acids; 38196 Da
Secondary accessions: A8K7I3 Q3SYC1 Q6ZQZ2 Q86UH6 Q9H630
Alternative splicing: 3 isoforms:  Q3SYC2-1   Q3SYC2-2   Q3SYC2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MOGAT2: NX_Q3SYC2

Explore proteomics data for MOGAT2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for MOGAT2 (Q3SYC2)
     PITTVVG  PLFHGRGVF 


    See MOGAT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079374.2  
    ENSEMBL proteins: 
     ENSP00000198801   ENSP00000436537   ENSP00000436283  

    MOGAT2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007130 DAGAT

    Graphical View of Domain Structure for InterPro Entry Q3SYC2

    ProtoNet protein and cluster: Q3SYC2

    UniProtKB/Swiss-Prot: MOGT2_HUMAN, Q3SYC2
    Similarity: Belongs to the diacylglycerol acyltransferase family


    Find genes that share domains with MOGAT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOGT2_HUMAN, Q3SYC2
    Function: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference
    toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a
    central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol
    in enterocytes. May play a role in diet-induced obesity
    Catalytic activity: Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol
    Enzyme regulation: Inhibited by oleic acid and sphingosine, while it is stimulated by phosphatidylcholine,
    phosphatidylserine and phosphatidic acid (By similarity)
    Biophysicochemical properties: Kinetic parameters: KM=45 uM for sn-1-monooleoylglycerol;

         Enzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.221

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038462-acylglycerol O-acyltransferase activity IEA--
    GO:0016407acetyltransferase activity IEA--
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    Find genes that share ontologies with MOGAT2           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mogat2):
     adipose tissue  digestive/alimentary  growth/size/body  homeostasis/metabolism  liver/biliary system 

    Find genes that share phenotypes with MOGAT2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MOGAT2: Mogat2tm1.1Ryyo Mogat2tm1Far

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MOGAT2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MOGT2_HUMAN, Q3SYC2: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular2
    golgi apparatus2
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA14966132
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MOGAT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MOGAT2 About    
    See pathways by source

    SuperPathContained pathways About
    1triacylglycerol biosynthesis
    Triacylglyceride Synthesis0.36
    2Fat digestion and absorption
    Fat digestion and absorption


    Find genes that share SuperPaths with MOGAT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MOGAT2
        Triacylglyceride Synthesis


    1 Kegg Pathway  (Kegg details for MOGAT2):
        Fat digestion and absorption

    UniProtKB/Swiss-Prot: MOGT2_HUMAN, Q3SYC2
    Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MOGAT2
    Interactions:

        Search GeneGlobe Interaction Network for MOGAT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MOGAT2 (Q3SYC23 ENSP000001988014) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCDO007673, ENSP000003593804I2D: score=1 STRING: ENSP00000359380
    LPIN3Q9BQK83, ENSP000003623544I2D: score=1 STRING: ENSP00000362354
    NAPBQ9H1153I2D: score=2 
    COG3Q96JB23I2D: score=1 
    DNAJA1P316893I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006071glycerol metabolic process IEA--
    GO:0006629lipid metabolic process ----
    GO:0006651diacylglycerol biosynthetic process IEA--
    GO:0019432triglyceride biosynthetic process IEA--
    GO:0050892intestinal absorption IEA--

    Find genes that share ontologies with MOGAT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MOGAT2 (MOGT2)

    Selected HMDB Compounds for MOGAT2 (see all 2438)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Arachidonylglycerol2-Arachidonyl glycerol;(all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid (see all 21)53847-30-6--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MOGAT2 gene: 
    NM_025098.2  

    Unigene Cluster for MOGAT2:

    Monoacylglycerol O-acyltransferase 2
    Hs.288568  [show with all ESTs]
    Unigene Representative Sequence: AK128620
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000198801(uc010rru.2) ENST00000525093(uc001oww.1) ENST00000526712(uc010rrv.2)

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    Additional mRNA sequence: 

    AK000245.1 AK026297.1 AK128620.1 AK291998.1 AY157608.1 BC103876.1 BC103877.1 BC103878.1 
    Z11852.1 

    5 DOTS entries:

    DT.101979655  DT.100741159  DT.91973467  DT.92068044  DT.102820712 

    Selected AceView cDNA sequences (see all 27):

    NM_025098 AK128620 AY157608 AK000245 BG674053 BM819465 BX482703 AA722886 
    AK026297 BF374574 BF374729 AW852653 AW841567 CD632454 AW852902 AW810630 
    BF374587 CD632453 AW176389 BF374606 BG980610 AW809961 D25664 BG980611 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MOGAT2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:              -                             -               
    SP2:              -                             -               
    SP3:                                            -               
    SP4:              -                                             


    ECgene alternative splicing isoforms for MOGAT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MOGAT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATGCCATA
    MOGAT2 Expression
    About this image


    MOGAT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Proximal Tubule Cells Proximal Tubule
             Proximal Tubule
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Stem Cell line 5
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
    MOGAT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MOGAT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.288568

    UniProtKB/Swiss-Prot: MOGT2_HUMAN, Q3SYC2
    Tissue specificity: Highly expressed in liver, small intestine, colon, stomach and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MOGAT2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mogat21 , 5 monoacylglycerol O-acyltransferase 21, 5 82.34(n)1
    81.14(a)1
      7 (54.03 cM)5
    2335491  NM_177448.41  NP_803231.11 
     992190845 
    chicken
    (Gallus gallus)
    Aves MOGAT21 monoacylglycerol O-acyltransferase 2 69.08(n)
    69.88(a)
      426437  XM_004938991.1  XP_004939048.1 
    lizard
    (Anolis carolinensis)
    Reptilia MOGAT26
    monoacylglycerol O-acyltransferase 2
    62(a)
    1 ↔ 1
    GL343298.1(1211312-1248794)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mogat11 monoacylglycerol O-acyltransferase 1 64.66(n)
    63.66(a)
      100145079  XM_002941166.2  XP_002941212.2 
    zebrafish
    (Danio rerio)
    Actinopterygii mogat21 monoacylglycerol O-acyltransferase 2 63.75(n)
    65.74(a)
      450063  NM_001006083.1  NP_001006083.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG19421 CG1942 49.22(n)
    41.69(a)
      35719  NM_136474.2  NP_610318.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dgtr-11 dgtr-1 49.24(n)
    45.9(a)
      189077  NM_072248.4  NP_504649.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DGA1(YOR245C)4 Diacylglycerol acyltransferase, catalyzes the terminal more   --   15(795332-794076) 854419  NP_014888.1 


    ENSEMBL Gene Tree for MOGAT2 (if available)
    TreeFam Gene Tree for MOGAT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MOGAT2 gene
    MOGAT32  DGAT22  MOGAT12  DGAT2L62  AWAT22  AWAT12  
    7 SIMAP similar genes for MOGAT2 using alignment to 1 protein entry:     MOGT2_HUMAN:
    MOGAT1    DGAT2    MOGAT3    AWAT1    AWAT2    DGAT2L6
    DGAT2L7P

    Find genes that share paralogs with MOGAT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MOGAT2 (see all 432)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122949691,2
    C,F,H--75427074(+) agttgT/Ctagga 1 -- us2k16Minor allele frequency- C:0.07NS EA WA 540
    rs1153523561,2
    F--75427250(+) GAAATG/ATGTAT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs794813411,2
    F--75427261(+) AGATGT/AGTACT 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1454063981,2
    --75427279(+) ATGTAA/CAGGAA 1 -- us2k10--------
    rs1472732791,2
    --75427313(+) ATAGCC/TAGAAA 1 -- us2k10--------
    rs6951551,2
    C,F,A,H--75427612(+) TGTCCA/GCTTAG 1 -- us2k133Minor allele frequency- G:0.19NS EA NA WA CSA 3026
    rs1862167261,2
    --75427618(+) CTTAGG/TATTTG 1 -- us2k10--------
    rs1408901761,2
    --75427621(+) AGGATC/TTGTGC 1 -- us2k10--------
    rs1891283721,2
    --75427676(+) AAAAGA/GAGGGA 1 -- us2k10--------
    rs1498289341,2
    --75427792(+) TTACCC/TTTTAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MOGAT2 (75428864 - 75444003 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MOGAT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1010460CNV Insertion20482838
    nsv897924CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MOGAT2
    DNA2.0 Custom Variant and Variant Library Synthesis for MOGAT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610270    OMIM disorders: --


    Find genes that share disorders with MOGAT2           About GenesLikeMe


    Export disorders for MOGAT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MOGAT2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with MOGAT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity. (PubMed id 12824082)1, 2 Lockwood J.F.... Shi Y. (Am. J. Physiol. 2003)
    4. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PubMed id 14970677)1, 3 Winter A....Fries R. (Cytogenet. Genome Res. 2003)
    5. MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine. (PubMed id 12621063)1, 2 Yen C.-L.E. and Farese R.V. Jr. (J. Biol. Chem. 2003)
    6. A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet. (PubMed id 14966132)1, 9 Cao J....Shi Y. (J. Biol. Chem. 2004)
    7. Intestine-specific expression of MOGAT2 partially restores metabolic efficiency in Mogat2-deficient mice. (PubMed id 23536640)1 Gao Y....Yen C.L. (J. Lipid Res. 2013)
    8. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PubMed id 12486725)6 Kurz M....Kramer W. (Proteins 2003)
    9. Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2. (PubMed id 12576479)1 Cao J....Shi Y. (J. Biol. Chem. 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80168 HGNC: 23248 AceView: MOGAT2 Ensembl:ENSG00000166391 euGenes: HUgn80168
    ECgene: MOGAT2 Kegg: 80168 H-InvDB: MOGAT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MOGAT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MOGAT2 gene:
    Search GeneIP for patents involving MOGAT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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