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Aliases for MOGAT2 Gene

Aliases for MOGAT2 Gene

  • Monoacylglycerol O-Acyltransferase 2 2 3 4 5
  • Diacylglycerol Acyltransferase 2-Like Protein 5 3 4
  • Diacylglycerol O-Acyltransferase Candidate 5 3 4
  • Acyl-CoA:Monoacylglycerol Acyltransferase 2 3 4
  • DGAT2L5 3 4
  • MGAT2 3 4
  • HDC5 3 4
  • EC 2.3.1.22 4
  • DGAT2L5. 3
  • EC 2.3.1 63
  • HMGAT2 4
  • DC5 4

External Ids for MOGAT2 Gene

Previous GeneCards Identifiers for MOGAT2 Gene

  • GC11P075156
  • GC11P075106
  • GC11P075428
  • GC11P071726

Summaries for MOGAT2 Gene

Entrez Gene Summary for MOGAT2 Gene

  • The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]

GeneCards Summary for MOGAT2 Gene

MOGAT2 (Monoacylglycerol O-Acyltransferase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and 2-acylglycerol O-acyltransferase activity. An important paralog of this gene is MOGAT1.

UniProtKB/Swiss-Prot for MOGAT2 Gene

  • Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.

Gene Wiki entry for MOGAT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOGAT2 Gene

Genomics for MOGAT2 Gene

Regulatory Elements for MOGAT2 Gene

Promoters for MOGAT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MOGAT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MOGAT2 Gene

Chromosome:
11
Start:
75,717,819 bp from pter
End:
75,732,958 bp from pter
Size:
15,140 bases
Orientation:
Plus strand

Genomic View for MOGAT2 Gene

Genes around MOGAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOGAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOGAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOGAT2 Gene

Proteins for MOGAT2 Gene

  • Protein details for MOGAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SYC2-MOGT2_HUMAN
    Recommended name:
    2-acylglycerol O-acyltransferase 2
    Protein Accession:
    Q3SYC2
    Secondary Accessions:
    • A8K7I3
    • Q3SYC1
    • Q6ZQZ2
    • Q86UH6
    • Q9H630

    Protein attributes for MOGAT2 Gene

    Size:
    334 amino acids
    Molecular mass:
    38196 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MOGAT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOGAT2 Gene

Proteomics data for MOGAT2 Gene at MOPED

Selected DME Specific Peptides for MOGAT2 Gene

Post-translational modifications for MOGAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MOGAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for MOGAT2 Gene

Gene Families for MOGAT2 Gene

Protein Domains for MOGAT2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MOGAT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3SYC2

UniProtKB/Swiss-Prot:

MOGT2_HUMAN :
  • Belongs to the diacylglycerol acyltransferase family.
Family:
  • Belongs to the diacylglycerol acyltransferase family.
genes like me logo Genes that share domains with MOGAT2: view

Function for MOGAT2 Gene

Molecular function for MOGAT2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=45 uM for sn-1-monooleoylglycerol {ECO:0000269 PubMed:12621063};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by oleic acid and sphingosine, while it is stimulated by phosphatidylcholine, phosphatidylserine and phosphatidic acid.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.

Enzyme Numbers (IUBMB) for MOGAT2 Gene

genes like me logo Genes that share phenotypes with MOGAT2: view

Animal Models for MOGAT2 Gene

MGI Knock Outs for MOGAT2:

Animal Model Products

CRISPR Products

miRNA for MOGAT2 Gene

miRTarBase miRNAs that target MOGAT2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOGAT2 Gene

Localization for MOGAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOGAT2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOGAT2 Gene COMPARTMENTS Subcellular localization image for MOGAT2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for MOGAT2 Gene

Pathways & Interactions for MOGAT2 Gene

genes like me logo Genes that share pathways with MOGAT2: view

UniProtKB/Swiss-Prot Q3SYC2-MOGT2_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis.

Gene Ontology (GO) - Biological Process for MOGAT2 Gene

None

No data available for SIGNOR curated interactions for MOGAT2 Gene

Drugs & Compounds for MOGAT2 Gene

(3) Drugs for MOGAT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
oleic acid Experimental Pharma Full agonist, Agonist 0
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(240) Additional Compounds for MOGAT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with MOGAT2: view

Transcripts for MOGAT2 Gene

Unigene Clusters for MOGAT2 Gene

Monoacylglycerol O-acyltransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOGAT2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for MOGAT2 Gene

GeneLoc Exon Structure for
MOGAT2
ECgene alternative splicing isoforms for
MOGAT2

Expression for MOGAT2 Gene

mRNA expression in normal human tissues for MOGAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOGAT2 Gene

This gene is overexpressed in Liver (x23.5), Colon - Transverse (x13.1), and Small Intestine - Terminal Ileum (x12.7).

Protein differential expression in normal tissues from HIPED for MOGAT2 Gene

This gene is overexpressed in Rectum (28.3), Fetal gut (22.3), and Colon (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MOGAT2 Gene



SOURCE GeneReport for Unigene cluster for MOGAT2 Gene Hs.288568

mRNA Expression by UniProt/SwissProt for MOGAT2 Gene

Q3SYC2-MOGT2_HUMAN
Tissue specificity: Highly expressed in liver, small intestine, colon, stomach and kidney.
genes like me logo Genes that share expression patterns with MOGAT2: view

Protein tissue co-expression partners for MOGAT2 Gene

Primer Products

In Situ Assay Products

Orthologs for MOGAT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOGAT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MOGAT2 35
  • 77.11 (n)
  • 66.87 (a)
-- 36
  • 70 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
MOGAT2 36
  • 73 (a)
OneToMany
MOGAT2 36
  • 67 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MOGAT2 35
  • 83.73 (n)
  • 82.04 (a)
MOGAT2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mogat2 35
  • 82.34 (n)
  • 81.14 (a)
Mogat2 16
Mogat2 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MOGAT2 35
  • 99.5 (n)
  • 99.7 (a)
MOGAT2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mogat2 35
  • 81.84 (n)
  • 80.84 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MOGAT2 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOGAT2 35
  • 69.08 (n)
  • 69.88 (a)
-- 36
  • 70 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MOGAT2 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mogat1 35
  • 64.66 (n)
  • 63.66 (a)
zebrafish
(Danio rerio)
Actinopterygii mogat2 35
  • 63.75 (n)
  • 65.74 (a)
mogat2 36
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005949 35
  • 53.54 (n)
  • 45.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1942 35
  • 49.22 (n)
  • 41.69 (a)
CG1941 36
  • 35 (a)
ManyToMany
CG1942 36
  • 37 (a)
ManyToMany
CG1946 36
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dgtr-1 35
  • 49.24 (n)
  • 45.9 (a)
dgat-2 36
  • 43 (a)
ManyToMany
dgtr-1 36
  • 42 (a)
ManyToMany
K07B1.4 36
  • 39 (a)
ManyToMany
Y53G8B.2 36
  • 42 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DGA1 36
  • 31 (a)
OneToMany
DGA1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
Species with no ortholog for MOGAT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOGAT2 Gene

ENSEMBL:
Gene Tree for MOGAT2 (if available)
TreeFam:
Gene Tree for MOGAT2 (if available)

Paralogs for MOGAT2 Gene

Paralogs for MOGAT2 Gene

(7) SIMAP similar genes for MOGAT2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOGAT2: view

Variants for MOGAT2 Gene

Sequence variations from dbSNP and Humsavar for MOGAT2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_027390 -
rs12281468 - 75,731,219(+) GCTGT(A/G)CAACC downstream-variant-500B, reference, missense
rs34582952 - 75,728,081(+) CAGGC(A/C)TGGAT nc-transcript-variant, reference, missense
rs519091 -- 75,725,003(-) aattt(G/T)tcatc intron-variant
rs543886 -- 75,724,380(-) TCTGT(A/G)CTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOGAT2 Gene

Variant ID Type Subtype PubMed ID
nsv897924 CNV Gain 21882294
esv1010460 CNV Insertion 20482838

Variation tolerance for MOGAT2 Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.56; 72.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOGAT2 Gene

HapMap Linkage Disequilibrium report
MOGAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOGAT2 Gene

Disorders for MOGAT2 Gene

Relevant External Links for MOGAT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOGAT2

No disorders were found for MOGAT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOGAT2 Gene

Publications for MOGAT2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet. (PMID: 14966132) Cao J. … Shi Y. (J. Biol. Chem. 2004) 3 23
  3. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A. … Fries R. (Cytogenet. Genome Res. 2003) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Monoacylglycerol acyltransferase-2 is a tetrameric enzyme that selectively heterodimerizes with diacylglycerol acyltransferase-1. (PMID: 24573674) Zhang J. … Shi Y. (J. Biol. Chem. 2014) 3

Products for MOGAT2 Gene

Sources for MOGAT2 Gene

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