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Aliases for MOGAT2 Gene

Aliases for MOGAT2 Gene

  • Monoacylglycerol O-Acyltransferase 2 2 3 4 5
  • Diacylglycerol Acyltransferase 2-Like Protein 5 3 4
  • Diacylglycerol O-Acyltransferase Candidate 5 3 4
  • Acyl-CoA:Monoacylglycerol Acyltransferase 2 3 4
  • DGAT2L5 3 4
  • MGAT2 3 4
  • HDC5 3 4
  • 2-Acylglycerol O-Acyltransferase 2 3
  • EC 2.3.1.22 4
  • DGAT2L5. 3
  • EC 2.3.1 61
  • HMGAT2 4
  • DC5 4

External Ids for MOGAT2 Gene

Previous GeneCards Identifiers for MOGAT2 Gene

  • GC11P075156
  • GC11P075106
  • GC11P075428
  • GC11P071726

Summaries for MOGAT2 Gene

Entrez Gene Summary for MOGAT2 Gene

  • The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]

GeneCards Summary for MOGAT2 Gene

MOGAT2 (Monoacylglycerol O-Acyltransferase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Fat digestion and absorption. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and 2-acylglycerol O-acyltransferase activity. An important paralog of this gene is MOGAT1.

UniProtKB/Swiss-Prot for MOGAT2 Gene

  • Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.

Gene Wiki entry for MOGAT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOGAT2 Gene

Genomics for MOGAT2 Gene

Regulatory Elements for MOGAT2 Gene

Enhancers for MOGAT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F075748 0.2 Ensembl 12.1 +31.1 31091 0.6 LEF1 PKNOX1 NFRKB FOXA1 GATA3 FOXK2 IKZF1 TRIM24 ZBTB33 MOGAT2 DGAT2 RN7SL786P
GH11F075771 0.7 FANTOM5 ENCODE 11.5 +54.0 54005 0.5 ZNF639 SAP130 NFIA ZBTB11 ARID4B RAD21 DGAT2 ENSG00000254814 MOGAT2 UVRAG ENSG00000254826 LOC283214
GH11F075775 0.7 Ensembl 11.5 +57.7 57682 0.6 CTCF ZMYM3 KDM1A ENSG00000254814 MOGAT2 ENSG00000254826 LOC283214
GH11F075772 1 ENCODE 11.5 +55.5 55453 2.2 HDGF PKNOX1 ARID4B BMI1 RAD21 GTF3C2 ZNF143 ZNF207 ETV6 CREM ENSG00000254814 DGAT2 MOGAT2 RN7SL239P ENSG00000254826 LOC283214
GH11F075777 0.6 Ensembl 11.5 +60.0 59999 1.6 JUND ETV1 JUN PRDM10 ETV6 DGAT2 ENSG00000254814 MOGAT2 ENSG00000254826
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MOGAT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MOGAT2 Gene

Chromosome:
11
Start:
75,717,819 bp from pter
End:
75,732,958 bp from pter
Size:
15,140 bases
Orientation:
Plus strand

Genomic View for MOGAT2 Gene

Genes around MOGAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOGAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOGAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOGAT2 Gene

Proteins for MOGAT2 Gene

  • Protein details for MOGAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SYC2-MOGT2_HUMAN
    Recommended name:
    2-acylglycerol O-acyltransferase 2
    Protein Accession:
    Q3SYC2
    Secondary Accessions:
    • A8K7I3
    • Q3SYC1
    • Q6ZQZ2
    • Q86UH6
    • Q9H630

    Protein attributes for MOGAT2 Gene

    Size:
    334 amino acids
    Molecular mass:
    38196 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MOGAT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOGAT2 Gene

Selected DME Specific Peptides for MOGAT2 Gene

Q3SYC2:
  • PLFHGRGVF
  • PITTVVG

Post-translational modifications for MOGAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MOGAT2 Gene

Domains & Families for MOGAT2 Gene

Gene Families for MOGAT2 Gene

Protein Domains for MOGAT2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MOGAT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3SYC2

UniProtKB/Swiss-Prot:

MOGT2_HUMAN :
  • Belongs to the diacylglycerol acyltransferase family.
Family:
  • Belongs to the diacylglycerol acyltransferase family.
genes like me logo Genes that share domains with MOGAT2: view

Function for MOGAT2 Gene

Molecular function for MOGAT2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=45 uM for sn-1-monooleoylglycerol {ECO:0000269 PubMed:12621063};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by oleic acid and sphingosine, while it is stimulated by phosphatidylcholine, phosphatidylserine and phosphatidic acid.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.

Enzyme Numbers (IUBMB) for MOGAT2 Gene

Gene Ontology (GO) - Molecular Function for MOGAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003846 2-acylglycerol O-acyltransferase activity TAS --
GO:0016407 acetyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IEA --
genes like me logo Genes that share ontologies with MOGAT2: view
genes like me logo Genes that share phenotypes with MOGAT2: view

Animal Models for MOGAT2 Gene

MGI Knock Outs for MOGAT2:

Animal Model Products

miRNA for MOGAT2 Gene

miRTarBase miRNAs that target MOGAT2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOGAT2 Gene

Localization for MOGAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOGAT2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOGAT2 Gene COMPARTMENTS Subcellular localization image for MOGAT2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MOGAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 14966132
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MOGAT2: view

Pathways & Interactions for MOGAT2 Gene

genes like me logo Genes that share pathways with MOGAT2: view

Pathways by source for MOGAT2 Gene

UniProtKB/Swiss-Prot Q3SYC2-MOGT2_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis.

Gene Ontology (GO) - Biological Process for MOGAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006071 glycerol metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006651 diacylglycerol biosynthetic process IEA --
GO:0019432 triglyceride biosynthetic process TAS --
GO:0050892 intestinal absorption IEA --
genes like me logo Genes that share ontologies with MOGAT2: view

No data available for SIGNOR curated interactions for MOGAT2 Gene

Drugs & Compounds for MOGAT2 Gene

(3) Drugs for MOGAT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
oleic acid Approved, Vet_approved Pharma Full agonist, Agonist 0
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(240) Additional Compounds for MOGAT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with MOGAT2: view

Transcripts for MOGAT2 Gene

Unigene Clusters for MOGAT2 Gene

Monoacylglycerol O-acyltransferase 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOGAT2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for MOGAT2 Gene

GeneLoc Exon Structure for
MOGAT2
ECgene alternative splicing isoforms for
MOGAT2

Expression for MOGAT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MOGAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOGAT2 Gene

This gene is overexpressed in Liver (x23.5), Colon - Transverse (x13.1), and Small Intestine - Terminal Ileum (x12.7).

Protein differential expression in normal tissues from HIPED for MOGAT2 Gene

This gene is overexpressed in Rectum (28.3), Fetal gut (22.3), and Colon (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MOGAT2 Gene



Protein tissue co-expression partners for MOGAT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MOGAT2 Gene:

MOGAT2

SOURCE GeneReport for Unigene cluster for MOGAT2 Gene:

Hs.288568

mRNA Expression by UniProt/SwissProt for MOGAT2 Gene:

Q3SYC2-MOGT2_HUMAN
Tissue specificity: Highly expressed in liver, small intestine, colon, stomach and kidney.
genes like me logo Genes that share expression patterns with MOGAT2: view

Primer Products

Orthologs for MOGAT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOGAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOGAT2 34 35
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia MOGAT2 34 35
  • 83.73 (n)
mouse
(Mus musculus)
Mammalia Mogat2 34 16 35
  • 82.34 (n)
rat
(Rattus norvegicus)
Mammalia Mogat2 34
  • 81.84 (n)
cow
(Bos Taurus)
Mammalia MOGAT2 34 35 35
  • 77.11 (n)
-- 35
  • 74 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 73 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MOGAT2 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 70 (a)
OneToMany
MOGAT2 34
  • 69.08 (n)
-- 35
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MOGAT2 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mogat1 34
  • 64.66 (n)
zebrafish
(Danio rerio)
Actinopterygii mogat2 34 35
  • 63.75 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005949 34
  • 53.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1942 34 35
  • 49.22 (n)
CG1946 35
  • 37 (a)
ManyToMany
CG1941 35
  • 35 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dgtr-1 34 35
  • 49.24 (n)
dgat-2 35
  • 43 (a)
ManyToMany
Y53G8B.2 35
  • 42 (a)
ManyToMany
K07B1.4 35
  • 39 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DGA1 35 37
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToMany
Species where no ortholog for MOGAT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOGAT2 Gene

ENSEMBL:
Gene Tree for MOGAT2 (if available)
TreeFam:
Gene Tree for MOGAT2 (if available)

Paralogs for MOGAT2 Gene

Paralogs for MOGAT2 Gene

(7) SIMAP similar genes for MOGAT2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MOGAT2 Gene

genes like me logo Genes that share paralogs with MOGAT2: view

Variants for MOGAT2 Gene

Sequence variations from dbSNP and Humsavar for MOGAT2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10793123 -- 75,723,045(+) CAACC(A/T)CCACC intron-variant
rs10899102 -- 75,718,527(+) CATGC(A/C)TGACC intron-variant, upstream-variant-2KB
rs10899104 -- 75,729,490(+) GGCTG(G/T)TCTCA intron-variant
rs111318777 -- 75,733,174(+) CTTCT(C/G)AGTCT downstream-variant-500B
rs112043376 -- 75,723,398(+) CTGGG(A/C)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOGAT2 Gene

Variant ID Type Subtype PubMed ID
esv1010460 CNV insertion 20482838

Variation tolerance for MOGAT2 Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.56; 72.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOGAT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOGAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOGAT2 Gene

Disorders for MOGAT2 Gene

Relevant External Links for MOGAT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOGAT2

No disorders were found for MOGAT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOGAT2 Gene

Publications for MOGAT2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet. (PMID: 14966132) Cao J. … Shi Y. (J. Biol. Chem. 2004) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A. … Fries R. (Cytogenet. Genome Res. 2003) 2 3 64
  5. MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine. (PMID: 12621063) Yen C.-L.E. … Farese R.V. Jr. (J. Biol. Chem. 2003) 3 4 64

Products for MOGAT2 Gene

Sources for MOGAT2 Gene

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