Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MOGAT1 Gene

Aliases for MOGAT1 Gene

  • Monoacylglycerol O-Acyltransferase 1 2 3 4 5
  • Diacylglycerol Acyltransferase 2-Like Protein 1 3 4
  • Diacylglycerol O-Acyltransferase Candidate 2 3 4
  • Acyl-CoA:Monoacylglycerol Acyltransferase 1 3 4
  • Diacylglycerol O-Acyltransferase 2 Like 1 2 3
  • EC 4 63
  • DGAT2L1 3 4
  • MGAT1 3 4
  • HDC2 3 4
  • EC 2.3.1 63
  • DGAT2L 3
  • DC2 4

External Ids for MOGAT1 Gene

Previous HGNC Symbols for MOGAT1 Gene

  • DGAT2L1

Previous GeneCards Identifiers for MOGAT1 Gene

  • GC02P223739
  • GC02P223361
  • GC02P223244
  • GC02P223536
  • GC02P215389

Summaries for MOGAT1 Gene

Entrez Gene Summary for MOGAT1 Gene

  • Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC catalyzes the synthesis of diacylglycerols, the precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 [PubMed 12077311]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MOGAT1 Gene

MOGAT1 (Monoacylglycerol O-Acyltransferase 1) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and triacylglycerol biosynthesis. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and diacylglycerol O-acyltransferase activity. An important paralog of this gene is MOGAT2.

UniProtKB/Swiss-Prot for MOGAT1 Gene

  • Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOGAT1 Gene

Genomics for MOGAT1 Gene

Regulatory Elements for MOGAT1 Gene

Enhancers for MOGAT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MOGAT1 on UCSC Golden Path with GeneCards custom track

Promoters for MOGAT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MOGAT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MOGAT1 Gene

222,671,738 bp from pter
222,709,930 bp from pter
38,193 bases
Plus strand

Genomic View for MOGAT1 Gene

Genes around MOGAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOGAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOGAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOGAT1 Gene

Proteins for MOGAT1 Gene

  • Protein details for MOGAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    2-acylglycerol O-acyltransferase 1
    Protein Accession:
    Secondary Accessions:
    • Q6IEE5

    Protein attributes for MOGAT1 Gene

    335 amino acids
    Molecular mass:
    38812 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAX81987.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MOGAT1 Gene

Proteomics data for MOGAT1 Gene at MOPED

Selected DME Specific Peptides for MOGAT1 Gene

Post-translational modifications for MOGAT1 Gene

  • Glycosylation at Asn 121, Asn 125, and Asn 180
  • Modification sites at PhosphoSitePlus

Other Protein References for MOGAT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MOGAT1 Gene

Gene Families for MOGAT1 Gene

Protein Domains for MOGAT1 Gene


Suggested Antigen Peptide Sequences for MOGAT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the diacylglycerol acyltransferase family.
  • Belongs to the diacylglycerol acyltransferase family.
genes like me logo Genes that share domains with MOGAT1: view

Function for MOGAT1 Gene

Molecular function for MOGAT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity).

Enzyme Numbers (IUBMB) for MOGAT1 Gene

genes like me logo Genes that share phenotypes with MOGAT1: view

Animal Model Products

CRISPR Products

miRNA for MOGAT1 Gene

miRTarBase miRNAs that target MOGAT1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOGAT1 Gene

Localization for MOGAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOGAT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MOGAT1 Gene COMPARTMENTS Subcellular localization image for MOGAT1 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
mitochondrion 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MOGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MOGAT1: view

Pathways & Interactions for MOGAT1 Gene

genes like me logo Genes that share pathways with MOGAT1: view

Pathways by source for MOGAT1 Gene

UniProtKB/Swiss-Prot Q96PD6-MOGT1_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis.

Interacting Proteins for MOGAT1 Gene

Gene Ontology (GO) - Biological Process for MOGAT1 Gene


No data available for SIGNOR curated interactions for MOGAT1 Gene

Drugs & Compounds for MOGAT1 Gene

(2) Drugs for MOGAT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(101) Additional Compounds for MOGAT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
genes like me logo Genes that share compounds with MOGAT1: view

Transcripts for MOGAT1 Gene

mRNA/cDNA for MOGAT1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MOGAT1 Gene

Monoacylglycerol O-acyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOGAT1 Gene

No ASD Table

Relevant External Links for MOGAT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MOGAT1 Gene

mRNA expression in normal human tissues for MOGAT1 Gene

mRNA differential expression in normal tissues according to GTEx for MOGAT1 Gene

This gene is overexpressed in Liver (x13.2) and Adipose - Visceral (Omentum) (x4.7).

SOURCE GeneReport for Unigene cluster for MOGAT1 Gene Hs.344090

genes like me logo Genes that share expression patterns with MOGAT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MOGAT1 Gene

Orthologs for MOGAT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOGAT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MOGAT1 35
  • 83.88 (n)
  • 81.49 (a)
  • 81 (a)
(Canis familiaris)
Mammalia MOGAT1 35
  • 84.68 (n)
  • 80 (a)
  • 80 (a)
(Mus musculus)
Mammalia Mogat1 35
  • 77.41 (n)
  • 72.54 (a)
Mogat1 16
Mogat1 36
  • 73 (a)
(Pan troglodytes)
Mammalia MOGAT1 35
  • 98.91 (n)
  • 97.91 (a)
  • 98 (a)
(Monodelphis domestica)
Mammalia MOGAT1 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
(Gallus gallus)
Aves MOGAT1 35
  • 69.86 (n)
  • 66.01 (a)
  • 63 (a)
(Anolis carolinensis)
Reptilia MOGAT1 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mogat1 35
  • 65.77 (n)
  • 66.17 (a)
Str.8301 35
African clawed frog
(Xenopus laevis)
Amphibia dgat2l1-A-prov 35
(Danio rerio)
Actinopterygii Dr.12962 35
mogat3a 35
  • 60.33 (n)
  • 60.22 (a)
mogat3a 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1941 36
  • 33 (a)
CG1942 36
  • 34 (a)
CG1946 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea dgat-2 36
  • 39 (a)
dgtr-1 36
  • 40 (a)
K07B1.4 36
  • 42 (a)
Y53G8B.2 36
  • 41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR140C 35
  • 48.48 (n)
  • 38.87 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11165g 35
  • 48.95 (n)
  • 40.25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DGA1 35
  • 47.84 (n)
  • 39.75 (a)
DGA1 36
  • 30 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02665 35
  • 49.34 (n)
  • 41.03 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dga1 35
  • 50.23 (n)
  • 41.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for MOGAT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOGAT1 Gene

Gene Tree for MOGAT1 (if available)
Gene Tree for MOGAT1 (if available)

Paralogs for MOGAT1 Gene

Paralogs for MOGAT1 Gene

(7) SIMAP similar genes for MOGAT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOGAT1: view

Variants for MOGAT1 Gene

Sequence variations from dbSNP and Humsavar for MOGAT1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1868024 - 222,694,370(+) TGGTT(C/T)CAGTT reference, missense
rs35959734 - 222,671,822(+) AGCTG(A/G)CGCGG reference, missense
rs951997 -- 222,702,297(+) ACGAT(A/C/G)TTGAG intron-variant
rs952498 -- 222,680,264(-) TTCAA(A/C)CTGAA intron-variant
rs965535 -- 222,677,351(+) CGAGG(C/T)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOGAT1 Gene

Variant ID Type Subtype PubMed ID
nsv834551 CNV Gain+Loss 17160897
esv269856 CNV Insertion 20981092

Variation tolerance for MOGAT1 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.26; 85.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MOGAT1 Gene

Disorders for MOGAT1 Gene

Relevant External Links for MOGAT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MOGAT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOGAT1 Gene

Publications for MOGAT1 Gene

  1. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A. … Fries R. (Cytogenet. Genome Res. 2003) 2 3 4 67
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3
  4. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PMID: 12486725) Kurz M. … Kramer W. (Proteins 2003) 26
  5. Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. (PMID: 12077311) Yen C.L. … Farese R.V. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MOGAT1 Gene

Sources for MOGAT1 Gene