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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MOGAT1 Gene

protein-coding   GIFtS: 45
GCID: GC02P223536

monoacylglycerol O-acyltransferase 1

(Previous name: diacylglycerol O-acyltransferase 2 like 1 )
(Previous symbol: DGAT2L1)
  Search for MOGAT1
in our new
 Human Malady Compendium 
Biological research products
for MOGAT1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Monoacylglycerol O-Acyltransferase 11 2 3     Diacylglycerol O-Acyltransferase Candidate 22 3
DGAT2L11 2 3     HDC21
MGAT11 2 3     EC 2.3.1.223 8
DGAT2L1 2     2-Acylglycerol O-Acyltransferase 12
Diacylglycerol O-Acyltransferase 2 Like 11 2     DC23
Acyl-CoA:Monoacylglycerol Acyltransferase 12 3     EC 2.3.18
Diacylglycerol Acyltransferase 2-Like Protein 12 3     

External Ids:    HGNC: 182101   Entrez Gene: 1162552   Ensembl: ENSG000001240037   OMIM: 6102685   UniProtKB: Q96PD63   

Export aliases for MOGAT1 gene to outside databases

Previous GC identifers: GC02P223739 GC02P223361 GC02P223244 GC02P215389


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MOGAT1:
Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the
precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 (PubMed
12077311)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: MOGT1_HUMAN, Q96PD6
Function: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved
in absorption of dietary fat in the small intestine (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MOGAT1 gene promoter:
         NF-1   NF-1/L   CUTL1   Cdc5   POU2F1   FOXJ2 (long isoform)   POU2F1a   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOGAT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MOGAT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOGAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.1   Ensembl cytogenetic band:  2q36.1   HGNC cytogenetic band: 2q36.2

MOGAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOGAT1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P223536:  view genomic region     (about GC identifiers)

Start:
223,536,457 bp from pter      End:
223,574,649 bp from pter
Size:
38,193 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MOGT1_HUMAN, Q96PD6 (See protein sequence)
Recommended Name: 2-acylglycerol O-acyltransferase 1  
Size: 335 amino acids; 38812 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=AAX81987.1; Type=Erroneous gene model prediction;
Secondary accessions: Q6IEE5

Explore the universe of human proteins at neXtProt for MOGAT1: NX_Q96PD6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96PD6

  • 2 DME Specific Peptides for MOGAT1 (Q96PD6)
     LARRLQT  VLQWVLSFL 

    MOGAT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_477513.2  
    ENSEMBL proteins: 
     ENSP00000406674  

    Human Recombinant Protein Products: 
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    Uscn Proteins for MOGAT1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--


    MOGAT1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MOGAT1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007130 DAGAT

    Graphical View of Domain Structure for InterPro Entry Q96PD6

    ProtoNet protein and cluster: Q96PD6

    UniProtKB/Swiss-Prot: MOGT1_HUMAN, Q96PD6
    Similarity: Belongs to the diacylglycerol acyltransferase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MOGT1_HUMAN, Q96PD6
    Function: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved
    in absorption of dietary fat in the small intestine (By similarity)
    Catalytic activity: Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol

    Enzyme Numbers (IUBMB): EC 2.3.1.221 2 EC 2.3.12

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038462-acylglycerol O-acyltransferase activity IEA--
    GO:0004144diacylglycerol O-acyltransferase activity IEA--


    MOGAT1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1CDP-diacylglycerol biosynthesis I
    triacylglycerol biosynthesis0.50
    Triacylglyceride Synthesis0.17


    2 BioSystems Pathways for MOGAT1 
        Triacylglyceride Synthesis
    triacylglycerol biosynthesis


    UniProtKB/Swiss-Prot: MOGT1_HUMAN, Q96PD6
    Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOGAT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for MOGAT1 (ENSP000004066744) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    LPPR2ENSP000002514734STRING: ENSP00000251473
    LPPR3ENSP000003529624STRING: ENSP00000352962
    LPPR4ENSP000003592044STRING: ENSP00000359204
    PPAP2AENSP000002647754STRING: ENSP00000264775
    PPAP2CENSP000003296974STRING: ENSP00000329697
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006071glycerol metabolic process IEA--
    GO:0006651diacylglycerol biosynthetic process IEA--
    GO:0019432triglyceride biosynthetic process IEA--


    MOGAT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MOGAT1

    10/1226 HMDB Compounds for MOGAT1 (see all 1226)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Arachidonylglycerol2-Arachidonyl glycerol;(all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid (see all 21)53847-30-6--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Search CenterWatch for drugs/clinical trials and news about MOGAT1 / MOGT1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MOGAT1 gene: 
    NM_058165.2  

    Unigene Cluster for MOGAT1:

    Monoacylglycerol O-acyltransferase 1
    Hs.344090
    Unigene Representative Sequence: NM_058165
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000446656(uc010fws.1 uc010fwt.1)

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    Clone
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    Additional cDNA sequence: AF384163.1 

    1 DOTS entry:

    DT.97773568 

    3 AceView cDNA sequences:

    NM_058165 AF384163 BV172268 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MOGAT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGTTTGCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MOGAT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MOGAT1

    SOURCE GeneReport for Unigene cluster: Hs.344090
        SABiosciences Custom PCR Arrays for MOGAT1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOGAT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MOGAT1 gene from 9/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MOGAT11 monoacylglycerol O-acyltransferase 1 69.86(n)
    66.01(a)
      424811  XM_003641754.1  XP_003641802.1 
    lizard
    (Anolis carolinensis)
    Reptilia MOGAT16
    --
    63(a)
    1 ↔ 1
    3(25492054-25508227)
    African clawed frog
    (Xenopus laevis)
    Amphibia dgat2l1-A-prov2 diacylglycerol O-acyltransferase 2 like 1 75.67(n)    BC045058.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.129622 Transcribed sequence with weak similarity to protein more 72.29(n)    BI892166.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG19426
    CG19466
    (see all 3)
    --
    33(a)
    33(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    2R(3600128-3601695)
    2R(3602445-3604286)
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_F59A1.101 Protein F59A1.10 52.48(n)
    46.1(a)
      180160  NM_075068.3  NP_507469.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DGA11 Dga1p 47.6(n)
    39.38(a)
      854419   NP_014888.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G515206
    diacylglycerol O-acyltransferase 2
    24(a)
    possible ortholog
    3(19110596-19112760)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    diacylglycerol O-acyltransferase, putative, expres...
    diacylglycerol O-acyltransferase, putative, expres...
    25(a)
    22(a)
    possible ortholog
    possible ortholog
    2(29593105-29595977)
    6(12808567-12811496)


    ENSEMBL Gene Tree for MOGAT1 (if available)
    TreeFam Gene Tree for MOGAT1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MOGAT1 gene
    MOGAT32  DGAT2L7P2  DGAT22  DGAT2L62  AWAT22  AWAT12  MOGAT22  
    7 SIMAP similar genes for MOGAT1 using alignment to 1 protein entry:     MOGT1_HUMAN:
    MOGAT2    DGAT2    DGAT2L6    MOGAT3    AWAT1    AWAT2
    DGAT2L7P

    MOGAT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/798 NCBI SNPs in MOGAT1 are shown (see all 798    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs64363261,2
    C,F,H,--223534463(+) TGAGGG/TCTCTG 1 -- us2k124Minor allele frequency- T:0.23NS EA NA WA CSA 2352
    rs1920912781,2
    --223534473(+) GCAGAA/GTGCCT 1 -- us2k10--------
    rs64363271,2
    C,--223534495(+) TGTTCA/GTAGTG 1 -- us2k112Minor allele frequency- G:0.24NA WA CSA EA 374
    rs1831252991,2
    --223534917(+) ACTGCA/TCTTGG 1 -- us2k10--------
    rs1166938721,2
    F,--223534937(+) TTGAAC/GCCTAA 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1878767331,2
    --223535278(+) CAAGAA/CAATGA 1 -- us2k10--------
    rs1932916511,2
    --223535355(+) TCCAGA/GTGGCC 1 -- us2k10--------
    rs1841335451,2
    --223535359(+) GGTGGC/TCTGCA 1 -- us2k10--------
    rs1878674211,2
    --223535364(+) CCTGCA/CGGAGC 1 -- us2k10--------
    rs101692231,2
    C,F,A,H,--223535457(+) ATTTTG/ACCATT 1 -- us2k118Minor allele frequency- A:0.27NS EA NA WA CSA 793

    HapMap Linkage Disequilibrium report for MOGAT1 (223536457 - 223574649 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MOGAT1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MOGAT1
    DNA2.0 Custom Variant and Variant Library Synthesis for MOGAT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MOGAT1 for disorders           About MalaCards

    MOGAT1 for disorders           About GeneDecksing

    OMIM gene information: 610268    OMIM disorders: --


    Export disorders for MOGAT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MOGAT1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MOGAT1)
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    1. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PubMed id 14970677)1, 2, 3 Winter A....Fries R. (2003)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. (PubMed id 11481335)1, 2 Cases S.... Farese R.V. Jr. (2001)
    4. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PubMed id 12486725)6 Kurz M....Kramer W. (2003)
    5. Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. (PubMed id 12077311)1 Yen C.L....Farese R.V. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116255 HGNC: 18210 AceView: MOGAT1 Ensembl:ENSG00000124003 euGenes: HUgn116255
    ECgene: MOGAT1 H-InvDB: MOGAT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MOGAT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MOGAT1 gene:
    Search GeneIP for patents involving MOGAT1

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