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Aliases for MOGAT1 Gene

Aliases for MOGAT1 Gene

  • Monoacylglycerol O-Acyltransferase 1 2 3 4
  • DGAT2L1 3 4 6
  • MGAT1 3 4 6
  • Diacylglycerol Acyltransferase 2-Like Protein 1 3 4
  • Diacylglycerol O-Acyltransferase Candidate 2 3 4
  • Acyl-CoA:Monoacylglycerol Acyltransferase 1 3 4
  • Diacylglycerol O-Acyltransferase 2 Like 1 2 3
  • EC 2.3.1.22 4 64
  • HDC2 3 4
  • 2-Acylglycerol O-Acyltransferase 1 3
  • EC 2.3.1 64
  • DGAT2L 3
  • DC2 4

External Ids for MOGAT1 Gene

Previous Symbols for MOGAT1 Gene

  • DGAT2L1

Summaries for MOGAT1 Gene

Entrez Gene Summary for MOGAT1 Gene

  • Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 [PubMed 12077311]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MOGAT1 Gene

MOGAT1 (Monoacylglycerol O-Acyltransferase 1) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include 2-acylglycerol O-acyltransferase activity and diacylglycerol O-acyltransferase activity. An important paralog of this gene is MOGAT2.

UniProtKB/Swiss-Prot for MOGAT1 Gene

  • Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOGAT1 Gene

Genomics for MOGAT1 Gene

Genomic Location for MOGAT1 Gene

Start:
222,671,738 bp from pter
End:
222,710,286 bp from pter
Size:
38,549 bases
Orientation:
Plus strand

Genomic View for MOGAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MOGAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOGAT1 Gene

Regulatory Elements for MOGAT1 Gene

Proteins for MOGAT1 Gene

  • Protein details for MOGAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PD6-MOGT1_HUMAN
    Recommended name:
    2-acylglycerol O-acyltransferase 1
    Protein Accession:
    Q96PD6
    Secondary Accessions:
    • Q6IEE5

    Protein attributes for MOGAT1 Gene

    Size:
    335 amino acids
    Molecular mass:
    38812 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX81987.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MOGAT1 Gene

Proteomics data for MOGAT1 Gene at MOPED

Selected DME Specific Peptides for MOGAT1 Gene

Post-translational modifications for MOGAT1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn121, Asn125, and Asn180

Other Protein References for MOGAT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for MOGAT1 Gene

Protein Domains for MOGAT1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MOGT1_HUMAN
Family:
  • Belongs to the diacylglycerol acyltransferase family.:
    • Q96PD6
genes like me logo Genes that share domains with MOGAT1: view

No data available for Gene Families for MOGAT1 Gene

Function for MOGAT1 Gene

Molecular function for MOGAT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol
UniProtKB/Swiss-Prot Function: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity).

Enzyme Numbers (IUBMB) for MOGAT1 Gene

Gene Ontology (GO) - Molecular Function for MOGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003846 2-acylglycerol O-acyltransferase activity IEA --
GO:0004144 diacylglycerol O-acyltransferase activity IEA --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
genes like me logo Genes that share ontologies with MOGAT1: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MOGAT1 Gene

Localization for MOGAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOGAT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOGAT1 Gene COMPARTMENTS Subcellular localization image for MOGAT1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
mitochondrion 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MOGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MOGAT1: view

Pathways for MOGAT1 Gene

genes like me logo Genes that share pathways with MOGAT1: view

UniProtKB/Swiss-Prot Q96PD6-MOGT1_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis

Interacting Proteins for MOGAT1 Gene

Gene Ontology (GO) - Biological Process for MOGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006071 glycerol metabolic process IEA --
GO:0006651 diacylglycerol biosynthetic process IEA --
GO:0019432 triglyceride biosynthetic process IEA --
genes like me logo Genes that share ontologies with MOGAT1: view

Compounds for MOGAT1 Gene

(1226) HMDB Compounds for MOGAT1 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with MOGAT1: view

Transcripts for MOGAT1 Gene

mRNA/cDNA for MOGAT1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MOGAT1 Gene

Monoacylglycerol O-acyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOGAT1 Gene

No ASD Table

Relevant External Links for MOGAT1 Gene

GeneLoc Exon Structure for
MOGAT1
ECgene alternative splicing isoforms for
MOGAT1

Expression for MOGAT1 Gene

mRNA expression in normal human tissues for MOGAT1 Gene

mRNA differential expression in normal tissues according to GTEx for MOGAT1 Gene

This gene is overexpressed in Liver (13.2) and Adipose - Visceral (Omentum) (4.7).

SOURCE GeneReport for Unigene cluster for MOGAT1 Gene Hs.344090

genes like me logo Genes that share expressions with MOGAT1: view

Orthologs for MOGAT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOGAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOGAT1 36
  • 98.91 (n)
  • 97.91 (a)
MOGAT1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MOGAT1 36
  • 83.88 (n)
  • 81.49 (a)
MOGAT1 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOGAT1 36
  • 84.68 (n)
  • 80 (a)
MOGAT1 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mogat1 36
  • 77.41 (n)
  • 72.54 (a)
Mogat1 16
Mogat1 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MOGAT1 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 47 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MOGAT1 36
  • 69.86 (n)
  • 66.01 (a)
MOGAT1 37
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MOGAT1 37
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia dgat2l1-A-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mogat1 36
  • 65.77 (n)
  • 66.17 (a)
Str.8301 36
zebrafish
(Danio rerio)
Actinopterygii Dr.12962 36
mogat3a 36
  • 60.33 (n)
  • 60.22 (a)
mogat3a 37
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1941 37
  • 33 (a)
ManyToMany
CG1942 37
  • 34 (a)
ManyToMany
CG1946 37
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dgat-2 37
  • 39 (a)
ManyToMany
dgtr-1 37
  • 40 (a)
ManyToMany
K07B1.4 37
  • 42 (a)
ManyToMany
Y53G8B.2 37
  • 41 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR140C 36
  • 48.48 (n)
  • 38.87 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DGA1 36
  • 47.84 (n)
  • 39.75 (a)
DGA1 37
  • 30 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11165g 36
  • 48.95 (n)
  • 40.25 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02665 36
  • 49.34 (n)
  • 41.03 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dga1 36
  • 50.23 (n)
  • 41.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToMany
Species with no ortholog for MOGAT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOGAT1 Gene

ENSEMBL:
Gene Tree for MOGAT1 (if available)
TreeFam:
Gene Tree for MOGAT1 (if available)

Paralogs for MOGAT1 Gene

Paralogs for MOGAT1 Gene

Selected SIMAP similar genes for MOGAT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOGAT1: view

Variants for MOGAT1 Gene

Sequence variations from dbSNP and Humsavar for MOGAT1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs951997 -- 222,702,297(+) ACGAT(A/G)TTGAG intron-variant
rs952498 -- 222,680,264(-) TTCAA(A/C)CTGAA intron-variant
rs965535 -- 222,677,351(+) CGAGG(C/T)GGGTG intron-variant
rs1374536 -- 222,702,307(+) GGTGA(C/T)TGATA intron-variant
rs1447108 -- 222,677,512(+) CTGTT(A/G)TATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOGAT1 Gene

Variant ID Type Subtype PubMed ID
nsv834551 CNV Gain+Loss 17160897
esv269856 CNV Insertion 20981092

Relevant External Links for MOGAT1 Gene

HapMap Linkage Disequilibrium report
MOGAT1

Disorders for MOGAT1 Gene

No disorders were found for MOGAT1 Gene.

No data available for UniProtKB/Swiss-Prot for MOGAT1 Gene

Publications for MOGAT1 Gene

  1. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A. … Fries R. (Cytogenet. Genome Res. 2003) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. (PMID: 11481335) Cases S. … Farese R.V. Jr. (J. Biol. Chem. 2001) 3 4
  4. Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. (PMID: 12077311) Yen C.L. … Farese R.V. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3

Products for MOGAT1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MOGAT1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MOGAT1
    • Block miRNA regulation of MOGAT1 using miScript Target Protectors

    Sources for MOGAT1 Gene

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