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Aliases for MOG Gene

Aliases for MOG Gene

  • Myelin Oligodendrocyte Glycoprotein 2 3 5
  • MOG Ig-AluB 3
  • MOG Alpha-5 3
  • MOG AluA 3
  • MOG AluB 3
  • BTNL11 3
  • MOGIG2 3
  • NRCLP7 3
  • BTN6 3

External Ids for MOG Gene

Previous GeneCards Identifiers for MOG Gene

  • GC06P029682
  • GC06P029395
  • GC06P029732
  • GC06P029624
  • GC06P029431
  • GC06P029808
  • GC06P030070

Summaries for MOG Gene

Entrez Gene Summary for MOG Gene

  • The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for MOG Gene

MOG (Myelin Oligodendrocyte Glycoprotein) is a Protein Coding gene. Diseases associated with MOG include narcolepsy 7 and narcolepsy. Among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. An important paralog of this gene is BTNL8.

UniProtKB/Swiss-Prot for MOG Gene

  • Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.

  • (Microbial infection) Acts as a receptor for rubella virus.

Tocris Summary for MOG Gene

Gene Wiki entry for MOG Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOG Gene

Genomics for MOG Gene

Regulatory Elements for MOG Gene

Genomic Location for MOG Gene

Chromosome:
6
Start:
29,656,981 bp from pter
End:
29,672,372 bp from pter
Size:
15,392 bases
Orientation:
Plus strand

Genomic View for MOG Gene

Genes around MOG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MOG Gene

  • Protein details for MOG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16653-MOG_HUMAN
    Recommended name:
    Myelin-oligodendrocyte glycoprotein
    Protein Accession:
    Q16653
    Secondary Accessions:
    • A6NDR4
    • A6NNJ9
    • A8MY31
    • B0UZR9
    • E9PGF0
    • F8W9D5
    • O00713
    • O00714
    • O00715
    • Q13054
    • Q13055
    • Q14855
    • Q29ZN8
    • Q56UY0
    • Q5JNX7
    • Q5JNY1
    • Q5JNY2
    • Q5JNY4
    • Q5SSB5
    • Q5SSB6
    • Q5STL9
    • Q5STM0
    • Q5STM1
    • Q5STM2
    • Q5STM5
    • Q5SUK5
    • Q5SUK7
    • Q5SUK8
    • Q5SUK9
    • Q5SUL0
    • Q5SUL1
    • Q8IYG5
    • Q92891
    • Q92892
    • Q92893
    • Q92894
    • Q92895
    • Q93053
    • Q96KU9
    • Q96KV0
    • Q96KV1
    • Q99605

    Protein attributes for MOG Gene

    Size:
    247 amino acids
    Molecular mass:
    28193 Da
    Quaternary structure:
    • Homodimer (By similarity). May form heterodimers between the different isoforms (By similarity).
    • (Microbial infection) Interacts with rubella virus E2 glycoprotein.

    Three dimensional structures from OCA and Proteopedia for MOG Gene

    Alternative splice isoforms for MOG Gene

neXtProt entry for MOG Gene

Proteomics data for MOG Gene at MOPED

Post-translational modifications for MOG Gene

  • Glycosylation at Asn 60
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for MOG Gene

Domains & Families for MOG Gene

Gene Families for MOG Gene

Protein Domains for MOG Gene

Graphical View of Domain Structure for InterPro Entry

Q16653

UniProtKB/Swiss-Prot:

MOG_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with MOG: view

Function for MOG Gene

Molecular function for MOG Gene

GENATLAS Biochemistry:
myelin oligodendrocyte glycoprotein,26-28kDa,associated with multiple sclerosis susceptibility
UniProtKB/Swiss-Prot Function:
Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for rubella virus.
genes like me logo Genes that share phenotypes with MOG: view

Human Phenotype Ontology for MOG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MOG Gene

MGI Knock Outs for MOG:

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for MOG Gene

Localization for MOG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOG Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 5: Cell membrane; Multi-pass membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Cell membrane; Single-pass type I membrane protein.
Isoform 4: Cell membrane; Single-pass type I membrane protein.
Isoform 6: Cell membrane; Single-pass type I membrane protein.
Isoform 7: Cell membrane; Single-pass type I membrane protein.
Isoform 8: Cell membrane; Single-pass type I membrane protein.
Isoform 9: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOG Gene COMPARTMENTS Subcellular localization image for MOG gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045121 membrane raft IEA --
genes like me logo Genes that share ontologies with MOG: view

Pathways & Interactions for MOG Gene

genes like me logo Genes that share pathways with MOG: view

Pathways by source for MOG Gene

Interacting Proteins for MOG Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366095%0d%0a9606.ENSP00000368752%0d%0a
Selected Interacting proteins: ENSP00000366095 Q16653-MOG_HUMAN for MOG Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with MOG: view

No data available for SIGNOR curated interactions for MOG Gene

Drugs & Compounds for MOG Gene

(8) Drugs for MOG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(12) Additional Compounds for MOG Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
B2
115687-05-3
Etifoxine hydrochloride
56776-32-0
MOG (35-55)
149635-73-4
Nogo-66 (1-40)
475221-20-6
PLP (139-151)
122018-58-0
genes like me logo Genes that share compounds with MOG: view

Transcripts for MOG Gene

Unigene Clusters for MOG Gene

Myelin oligodendrocyte glycoprotein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOG Gene

No ASD Table

Relevant External Links for MOG Gene

GeneLoc Exon Structure for
MOG
ECgene alternative splicing isoforms for
MOG

Expression for MOG Gene

mRNA expression in normal human tissues for MOG Gene

mRNA differential expression in normal tissues according to GTEx for MOG Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x16.2), Brain - Substantia nigra (x8.3), and Brain - Hippocampus (x5.2).

Protein differential expression in normal tissues from HIPED for MOG Gene

This gene is overexpressed in Spinal cord (46.5) and Frontal cortex (20.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MOG Gene



SOURCE GeneReport for Unigene cluster for MOG Gene Hs.141308

mRNA Expression by UniProt/SwissProt for MOG Gene

Q16653-MOG_HUMAN
Tissue specificity: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
genes like me logo Genes that share expression patterns with MOG: view

Protein tissue co-expression partners for MOG Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for MOG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MOG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOG 35
  • 99.33 (n)
  • 99.19 (a)
MOG 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MOG 36
  • 89 (a)
OneToOne
MOG 35
  • 89.5 (n)
  • 94.06 (a)
dog
(Canis familiaris)
Mammalia MOG 35
  • 85.69 (n)
  • 89.95 (a)
MOG 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mog 36
  • 85 (a)
OneToOne
Mog 16
Mog 35
  • 83.81 (n)
  • 86.23 (a)
oppossum
(Monodelphis domestica)
Mammalia MOG 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MOG 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mog 35
  • 83.94 (n)
  • 89.09 (a)
chicken
(Gallus gallus)
Aves LOC100858529 35
  • 56.21 (n)
  • 43.22 (a)
Species with no ortholog for MOG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MOG Gene

ENSEMBL:
Gene Tree for MOG (if available)
TreeFam:
Gene Tree for MOG (if available)

Paralogs for MOG Gene

Pseudogenes.org Pseudogenes for MOG Gene

genes like me logo Genes that share paralogs with MOG: view

Variants for MOG Gene

Sequence variations from dbSNP and Humsavar for MOG Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2857766 - 29,666,226(+) TCACT(C/G)TTGGC reference, missense
rs3130253 - 29,666,235(+) GCCTC(A/G/T)TCTTC reference, missense
VAR_066415 Narcolepsy 7 (NRCLP7)
rs29228 -- 29,655,962(-) TTCTG(C/T)TTTTG upstream-variant-2KB
rs926828 -- 29,670,648(+) GTGGG(A/G)AAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOG Gene

Variant ID Type Subtype PubMed ID
dgv1908e1 CNV Complex 17122850

Variation tolerance for MOG Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.10; 75.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOG Gene

HapMap Linkage Disequilibrium report
MOG
Human Gene Mutation Database (HGMD)
MOG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOG Gene

Disorders for MOG Gene

MalaCards: The human disease database

(21) MalaCards diseases for MOG Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
narcolepsy 7
  • narcolepsy-cataplexy syndrome 7
narcolepsy
  • narcolepsy, without cataplexy
rubella
  • german measles
central nervous system disease
  • central nervous system diseases
nervous system disease
  • nervous system diseases
- elite association - COSMIC cancer census association via MalaCards
Search MOG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MOG_HUMAN
  • Narcolepsy 7 (NRCLP7) [MIM:614250]: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. {ECO:0000269 PubMed:21907016}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MOG

Genetic Association Database (GAD)
MOG
Human Genome Epidemiology (HuGE) Navigator
MOG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOG
genes like me logo Genes that share disorders with MOG: view

No data available for Genatlas for MOG Gene

Publications for MOG Gene

  1. Myelin/oligodendrocyte glycoprotein is alternatively spliced in humans but not mice. (PMID: 8915905) Ballenthin P.A. … Gardinier M.V. (J. Neurosci. Res. 1996) 3 4 23 67
  2. Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. (PMID: 19687098) McLaughlin K.A. … Wucherpfennig K.W. (J. Immunol. 2009) 3 23
  3. Myelin oligodendrocyte glycoprotein antibodies and multiple sclerosis in healthy young adults. (PMID: 18753473) Wang H. … Ascherio A. (Neurology 2008) 3 23
  4. A sequence variation in the MOG gene is involved in multiple sclerosis susceptibility in Italy. (PMID: 17928868) D'Alfonso S. … Momigliano-Richiardi P. (Genes Immun. 2008) 3 23
  5. SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. (PMID: 17971048) Burfoot R.K. … Rubio J.P. (Tissue Antigens 2008) 3 23

Products for MOG Gene

Sources for MOG Gene

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