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MOG Gene

protein-coding   GIFtS: 61
GCID: GC06P029624

Myelin Oligodendrocyte Glycoprotein

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myelin Oligodendrocyte Glycoprotein1 2     MOGIG22
NRCLP72 5     MOG Alpha-52
BTN62     MOG Ig-AluB2
BTNL112     Myelin-Oligodendrocyte Glycoprotein2

External Ids:    HGNC: 71971   Entrez Gene: 43402   Ensembl: ENSG000002046557   OMIM: 1594655   UniProtKB: Q166533   

Export aliases for MOG gene to outside databases

Previous GC identifers: GC06P029682 GC06P029395 GC06P029732 GC06P029431


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MOG Gene:
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost
surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated
demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell
communication. Alternatively spliced transcript variants encoding different isoforms have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for MOG Gene:
MOG (myelin oligodendrocyte glycoprotein) is a protein-coding gene. Diseases associated with MOG include allergic encephalomyelitis, and primary progressive multiple sclerosis. An important paralog of this gene is BTN3A2.

UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
Function: Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be
involved in completion and/or maintenance of the myelin sheath and in cell-cell communication

Gene Wiki entry for MOG (Myelin oligodendrocyte glycoprotein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MOG gene promoter:
         CREB   deltaCREB   MRF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOG promoter sequence
   Search Chromatin IP Primers for MOG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MOG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

MOG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOG gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P029624:  view genomic region     (about GC identifiers)

Start:
29,624,758 bp from pter      End:
29,640,149 bp from pter
Size:
15,392 bases      Orientation:
plus strand

Selected alternative locations (see all 7):
Chr6+,NT_167249 965,314-980,702      Chr6+,NT_167245 928,111-943,503      Chr6+,NT_113891.2 1,143,559-1,158,951     
Chr6+,NT_167244 928,284-943,674      Chr6+,NT_167248 928,077-943,469      Chr6+,NT_167246 927,718-943,106     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653 (See protein sequence)
Recommended Name: Myelin-oligodendrocyte glycoprotein precursor  
Size: 247 amino acids; 28193 Da
Subunit: Homodimer (By similarity). May form heterodimers between the different isoforms
Caution: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG)
1 PDB 3D structure from and Proteopedia for MOG:
1Q70 (3D)    
Secondary accessions: A6NDR4 A6NNJ9 A8MY31 B0UZR9 E9PGF0 F8W9D5 O00713 O00714 O00715 Q13054
Q13055 Q14855 Q29ZN8 Q56UY0 Q5JNX7 Q5JNY1 Q5JNY2 Q5JNY4 Q5SSB5 Q5SSB6 Q5STL9 Q5STM0 Q5STM1
Q5STM5 Q5SUK7 Q5SUK8 Q5SUK9 Q5SUL0 Q5SUL1 Q92891 Q92892 Q92893 Q92894 Q92895 Q93053 Q96KU9
Q96KV0 Q96KV1 Q99605
Alternative splicing: 12 isoforms:  Q16653-1   Q16653-2   Q16653-3   Q16653-4   Q16653-5   Q16653-6   Q16653-7   Q16653-8   
Q16653-9   Q16653-10   Q16653-11   Q16653-12   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for MOG: NX_Q16653

Explore proteomics data for MOG at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn60
  • Modification sites at PhosphoSitePlus

  • See MOG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001008229.1  NP_001008230.1  NP_001163889.1  NP_002424.3  NP_996532.2  NP_996533.2  NP_996534.2  NP_996535.2  
    NP_996537.3  

    ENSEMBL proteins: 
     ENSP00000366115   ENSP00000366101   ENSP00000366085   ENSP00000366091   ENSP00000379932  
     ENSP00000418090   ENSP00000420350   ENSP00000409394   ENSP00000366088   ENSP00000366095  
     ENSP00000379929   ENSP00000417405   ENSP00000410866   ENSP00000418872   ENSP00000366086  
     ENSP00000366100   ENSP00000431709  

    MOG Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for MOG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTN: Butyrophilins
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR016663 Myelin-oligodendrocyte_glycop
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q16653

    ProtoNet protein and cluster: Q16653

    1 Blocks protein domain: IPB003596 Immunoglobulin V-type

    UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    MOG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOG_HUMAN, Q16653
    Function: Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be
    involved in completion and/or maintenance of the myelin sheath and in cell-cell communication

         Genatlas biochemistry entry for MOG:
    myelin oligodendrocyte glycoprotein,26-28kDa,associated with multiple sclerosis susceptibility

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    MOG for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MOG:
     Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mog):
     behavior/neurological  cellular  growth/size/body  hematopoietic system  immune system 
     muscle  nervous system  vision/eye 

    MOG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mogtm1Reid for MOG

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MOG
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MOG
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    Selected qRT-PCR Assays for microRNAs that regulate MOG (see all 19):
    hsa-miR-3673 hsa-miR-29c hsa-miR-29a hsa-miR-1297 hsa-miR-1255a hsa-miR-891b hsa-miR-613 hsa-miR-26b
    SwitchGear 3'UTR luciferase reporter plasmidMOG 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MOG

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    GenScript: all cDNA clones in your preferred vector (see all 9): MOG (NM_002433)
    Sino Biological Human cDNA Clone for MOG
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOG

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MOG_HUMAN, Q16653: Isoform 1: Cell membrane; Multi-pass membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 5: Cell membrane; Multi-pass membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 4: Cell membrane; Single-pass type I membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 6: Cell membrane; Single-pass type I membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 7: Cell membrane; Single-pass type I membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 8: Cell membrane; Single-pass type I membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 9: Cell membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    extracellular2
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    MOG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MOG
    Interactions:

        Search GeneGlobe Interaction Network for MOG

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for MOG (Q166533 ENSP000003660954) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRNPP041563I2D: score=3 
    GRB2P629933I2D: score=2 
    OTUD4Q018043I2D: score=2 
    DLG4P783523I2D: score=1 
    GRIN2BQ132243I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007417central nervous system development TAS1373175
    GO:0034126positive regulation of MyD88-dependent toll-like receptor signaling pathway ISS--

    MOG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MOG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PLP (139-151)Encephalitogenic myelin proteolipid fragment[122018-58-0]
    ONO 2506Inhibits S100B synthesis; neuroprotective[185517-21-9]
    C3bot (154-182)Neurotrophic fragment of clostridial C3 protein[1246280-79-4]
    MOG (35-55)Encephalitogenic myelin oligodendrocyte glycoprotein fragment[149635-73-4]
    Nogo-66 (1-40)Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration[475221-20-6]

    Selected Novoseek inferred chemical compound relationships for MOG gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',3'-cyclic nucleotide 71.4 4 10739571 (1), 19473295 (1), 16109311 (1), 15765008 (1)
    glyceryl monooleate 62 10 2155836 (4), 1665456 (3), 11837661 (1)
    glatiramer acetate 42.6 8 8965116 (3), 14512144 (1)
    nitrendipine 22.1 2 1665456 (2)
    oxygen 3.06 1 17640057 (1)
    calcium 2.87 2 1665456 (1), 15634682 (1)
    glucose 1.98 3 2155836 (2)
    oleic acid 0 3 11837661 (1), 2155836 (1)
    phosphoinositide 0 3 2155836 (2)
    nitric oxide 0 1 19301098 (1)



    MOG for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MOG gene (10 alternative transcripts): 
    NM_001008228.2  NM_001008229.2  NM_001170418.1  NM_002433.4  NM_206809.3  NM_206810.3  NM_206811.3  NM_206812.3  
    NM_206814.5  NM_206813.4  

    Unigene Cluster for MOG:

    Myelin oligodendrocyte glycoprotein
    Hs.141308  [show with all ESTs]
    Unigene Representative Sequence: NM_206809
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000376917(uc003nna.3 uc011dlt.2 uc011dlv.2 uc011dlu.2 uc003nne.3 uc003nnf.3 uc003nng.3 uc003nni.3 uc003nnh.3 uc003nnj.3 uc003nnk.3)
    ENST00000376903 ENST00000376888 ENST00000376894(uc003nmy.2) ENST00000469353
    ENST00000396704 ENST00000483013 ENST00000490427 ENST00000416766 ENST00000376891
    ENST00000376898 ENST00000396701 ENST00000494692 ENST00000431798 ENST00000476244
    ENST00000469603 ENST00000485211 ENST00000376889
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate MOG (see all 19):
    hsa-miR-3673 hsa-miR-29c hsa-miR-29a hsa-miR-1297 hsa-miR-1255a hsa-miR-891b hsa-miR-613 hsa-miR-26b
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    Additional mRNA sequence: 

    AB209815.1 AK295213.1 AK308949.1 AK312892.1 AY566846.1 AY566847.1 AY566848.1 AY566851.1 
    AY566852.1 AY566853.1 AY566854.1 U18798.1 U18799.1 U18800.2 U18801.1 U18803.1 
    U18840.1 U18843.1 U64564.1 U64565.1 U64566.1 U64567.1 U64568.1 U64569.1 
    U64570.1 U64571.1 X74511.1 

    17 DOTS entries:

    DT.100021881  DT.97776718  DT.100758942  DT.86852541  DT.95374215  DT.92423560  DT.451713  DT.101957614 
    DT.92423563  DT.121305358  DT.121305379  DT.95374216  DT.100758944  DT.100038778  DT.100890108  DT.95115608 
    DT.99947945 

    Selected AceView cDNA sequences (see all 29):

    NM_206809 U64567 NM_002433 U64565 CR598447 BC035938 CR623648 U18801 
    U18843 NM_206813 X74511 U64570 U64569 NM_206812 U64568 NM_206811 
    NM_206810 U18798 U18803 U64566 U64571 U18840 U18799 NM_206814 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MOG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGCTTTAG
    MOG Expression
    About this image


    MOG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Thalamus
             Oligodendrocyte-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Spinal Cord White Matter
             Oligodendrocyte-like cells
     
     Oligodendrocytes (Nervous System)
             Oligodendrocyte-like cells
    MOG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MOG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.141308

    UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
    Tissue specificity: Found exclusively in the CNS, where it is localized on the surface of myelin and
    oligodendrocyte cytoplasmic membranes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MOG gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mog1 , 5 myelin oligodendrocyte glycoprotein1, 5 83.81(n)1
    86.23(a)1
      17 (19.16 cM)5
    174411  NM_010814.21  NP_034944.21 
     370107465 
    chicken
    (Gallus gallus)
    Aves LOC1008585291 myelin-oligodendrocyte glycoprotein-like 56.21(n)
    43.22(a)
      100858529  XM_003642236.2  XP_003642284.2 


    ENSEMBL Gene Tree for MOG (if available)
    TreeFam Gene Tree for MOG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MOG gene
    BTN3A22  BTN2A12  BTNL82  ERMAP2  BTN2A22  BTN3A32  BTN3A12  BTNL22  
    BTN1A12  BTNL32  BTNL92  
    11 SIMAP similar genes for MOG using alignment to 8 protein entries:     MOG_HUMAN (see all proteins):
    BTN1A1    BTN2A2    BTN3A1    BTN2A1    BTNL9    BTN3A2
    BTN3A3    BTNL3    BTNL2    BTNL10    CD276

    MOG for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MOG
    PGOHUM00000244015


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MOG (see all 494)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0664154
    Narcolepsy 7 (NRCLP7)4--see VAR_0664152 S C mis40--------
    rs1498518041,2
    C--29543327(+) GCTTCA/GGCCTC 9 -- us2k10--------
    rs1448709501,2
    --29543355(+) CAGGCA/GTGAGC 9 -- us2k10--------
    rs1151567231,2
    C,F--29543651(+) CCCTAG/CTGGTG 9 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1490367221,2
    C--29543727(+) AATAGC/TTTAAT 9 -- us2k10--------
    rs1924090371,2
    --29543830(+) TTTTTA/TATTGT 9 -- us2k10--------
    rs94685691,2
    C,F,H--29543882(+) GGCTCG/AGCAGG 9 -- us2k15Minor allele frequency- A:0.01NS EA WA 538
    rs603305201,2
    C--29544087(+) AAAAA-/ACCCCT 9 -- us2k10--------
    rs292541,2
    C,F,H--29544161(-) AGTCAA/GGATTG 9 -- us2k120Minor allele frequency- G:0.06NS EA NA 2522
    rs1838518881,2
    --29544259(+) ACTCAA/GCTGAC 9 -- us2k10--------

    HapMap Linkage Disequilibrium report for MOG (29624758 - 29640149 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MOG:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1908e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): MOG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MOG
    DNA2.0 Custom Variant and Variant Library Synthesis for MOG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 159465   
    OMIM disorders: 614250  
    UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
  • Narcolepsy 7 (NRCLP7) [MIM:614250]: Neurological disabling sleep disorder, characterized by excessive
    daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy,
    hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions,
    which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a
    sporadically occurring disorder but familial clustering has been observed. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • Selected diseases for MOG (see all 49):    
    About MalaCards
    allergic encephalomyelitis    primary progressive multiple sclerosis    narcolepsy 7    pediatric multiple sclerosis
    viral encephalitis    subacute sclerosing panencephalitis    optic neuritis    nervous system disease
    guillain-barre syndrome    neuritis    central nervous system disease    acute disseminated encephalomyelitis
    narcolepsy 1    multiple sclerosis    narcolepsy    neuromyelitis optica
    relapsing-remitting multiple sclerosis    adrenoleukodystrophy    encephalomyelitis    myasthenia gravis

    5 diseases from the University of Copenhagen DISEASES database for MOG:
    Multiple sclerosis     Optic neuritis     Acute disseminated encephalomyelitis     Hypersensitivity reaction type II disease
    Neuromyelitis optica

    MOG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for MOG gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    multiple sclerosis 88.7 104 12149493 (3), 7593547 (3), 9394837 (2), 10545390 (2) (see all 77)
    encephalomyelitis 86.1 32 11128602 (2), 1991822 (1), 8367453 (1), 12667650 (1) (see all 30)
    demyelination 84.4 50 11536329 (3), 1695240 (2), 15259003 (2), 11128602 (2) (see all 39)
    demyelinating diseases 77.4 14 8220243 (2), 20033986 (1), 12355425 (1), 17294606 (1) (see all 9)
    autoimmune response 66.7 15 9394837 (3), 8965116 (1), 11128602 (1), 11403222 (1) (see all 5)
    multiple sclerosis relapsing-remitting 58.2 1 17628700 (1)
    autoimmune diseases 58 4 11724443 (1), 20033986 (1), 9210466 (1), 11428934 (1)
    neurological disorders 54.2 14 9083925 (2), 8965116 (1), 9394837 (1), 12911279 (1) (see all 10)
    optic neuritis 53.1 2 12732654 (2)
    mimicry 49.3 6 11536329 (2), 14688379 (2), 14597104 (1), 14978022 (1)

    Genetic Association Database (GAD): MOG
    Human Genome Epidemiology (HuGE) Navigator: MOG (27 documents)

    Export disorders for MOG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MOG gene, integrated from 10 sources (see all 264):
    (articles sorted by number of sources associating them with MOG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Myelin/oligodendrocyte glycoprotein is alternatively spliced in humans but not mice. (PubMed id 8915905)1, 2, 9 Ballenthin P.A. and Gardinier M.V. (J. Neurosci. Res. 1996)
    2. A sequence variation in the MOG gene is involved in multiple sclerosis susceptibility in Italy. (PubMed id 17928868)1, 4, 9 D'Alfonso S....Momigliano-Richiardi P. (Genes Immun. 2008)
    3. Genetic study of the myelin oligodendrocyte glycoprotein (MOG) gene in schizophrenia. (PubMed id 15660663)1, 4, 9 Zai G....Kennedy J.L. (Genes Brain Behav. 2005)
    4. Myelin oligodendrocyte gene polymorphisms and childhood multiple sclerosis. (PubMed id 12149493)1, 4, 9 Ohlenbusch A....Hanefeld F. (Pediatr. Res. 2002)
    5. Characterization of cDNA and genomic clones encoding human myelin oligodendrocyte glycoprotein. (PubMed id 7790876)1, 2, 9 Hilton A.A.... Bernard C.C.A. (J. Neurochem. 1995)
    6. Characterization and expression of the cDNA coding for the human myelin/oligodendrocyte glycoprotein. (PubMed id 7964757)1, 2, 9 Pham-Dinh D.... Dautigny A. (J. Neurochem. 1994)
    7. Structure of the human myelin/oligodendrocyte glycoprotein gene and multiple alternative spliced isoforms. (PubMed id 8666381)1, 2, 9 Pham-Dinh D.... Dautigny A. (Genomics 1995)
    8. The human myelin oligodendrocyte glycoprotein (MOG) gene: complete nucleotide sequence and structural characterization. (PubMed id 8530032)1, 2, 9 Roth M.-P.... Coppin H. (Genomics 1995)
    9. SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. (PubMed id 17971048)1, 4, 9 Burfoot R.K....Rubio J.P. (Tissue Antigens 2008)
    10. A conformational study of the human and rat encephalitogenic myelin oligodendrocyte glycoprotein peptides 35-55. (PubMed id 9210466)1, 2, 9 Albouz-Abo S.... von Itzstein M. (Eur. J. Biochem. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4340 HGNC: 7197 AceView: MOG Ensembl:ENSG00000204655 euGenes: HUgn4340
    ECgene: MOG H-InvDB: MOG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MOG Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Myelin_oligodendrocyte_glycoprotein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MOG gene:
    Search GeneIP for patents involving MOG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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