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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MOCS3 Gene

protein-coding   GIFtS: 54
GCID: GC20P049575

molybdenum cofactor synthesis 3

 Explore 6 diseases affiliated with
MOCS3 via our new
 Human Malady Compendium 
Biological research products
for MOCS3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Molybdenum Cofactor Synthesis 31 2     DJ914P20.31
UBA41 2 3     Adenylyltransferase And Sulfurtransferase MOCS32
Molybdenum Cofactor Synthesis Protein 32 3     UBA4, Ubiquitin-Activating Enzyme E1 Homolog2
Molybdopterin Synthase Sulfurylase2 3     Ubiquitin-Like Modifier Activating Enzyme 42
MPT Synthase Sulfurylase2 3     

External Ids:    HGNC: 157651   Entrez Gene: 273042   Ensembl: ENSG000001242177   OMIM: 6092775   UniProtKB: O953963   

Export aliases for MOCS3 gene to outside databases

Previous GC identifers: GC20P049303 GC20P050213 GC20P050260 GC20P049008 GC20P046323


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MOCS3:
Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene
adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no
introns. A pseudogene of this gene is present on chromosome 14. (provided by RefSeq, Nov 2012)

UniProtKB/Swiss-Prot: MOCS3_HUMAN, O95396
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and
tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal
thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as
acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to
form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated
from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient
disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for
thiocarboxylation reactions

Gene Wiki entry for MOCS3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MOCS3 gene promoter:
         Max1   STAT5A   Roaz   C/EBPalpha   NRF-2   HOXA5   COMP1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOCS3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MOCS3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOCS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.13

MOCS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOCS3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P049575:  view genomic region     (about GC identifiers)

Start:
49,575,363 bp from pter      End:
49,577,820 bp from pter
Size:
2,458 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MOCS3_HUMAN, O95396 (See protein sequence)
Recommended Name: Adenylyltransferase and sulfurtransferase MOCS3  
Size: 460 amino acids; 49669 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with NFS1
Subcellular location: Cytoplasm, cytosol
1 PDB 3D structure from and Proteopedia for MOCS3:
3I2V (3D)    

Explore the universe of human proteins at neXtProt for MOCS3: NX_O95396

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95396

  • MOCS3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055299.1  
    ENSEMBL proteins: 
     ENSP00000244051  
    Reactome Protein details: O95396
    Human Recombinant Protein Products: 
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    Novus Biologicals MOCS3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MOCS3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    MOCS3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MOCS3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MOCS3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001763 Rhodanese-like_dom
     IPR009036 Molybdenum_cofac_synth_MoeB
     IPR000594 ThiF_NAD_FAD-bd
     IPR007901 MoeZ_MoeB
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry O95396

    ProtoNet protein and cluster: O95396

    3 Blocks protein families:
    IPB000594 UBA/THIF-type NAD/FAD binding fold
    IPB001763 Rhodanese-like
    IPB007901 MoeZ/MoeB


    UniProtKB/Swiss-Prot: MOCS3_HUMAN, O95396
    Similarity: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily
    Similarity: Contains 1 rhodanese domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MOCS3_HUMAN, O95396
    Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and
    tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal
    thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as
    acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to
    form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated
    from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient
    disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for
    thiocarboxylation reactions
    Catalytic activity: ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate +
    [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP
    Catalytic activity: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine
    desulfurase]-S-sulfanyl-L-cysteine = AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH +
    cysteine desulfurase
    Biophysicochemical properties: Kinetic parameters: KM=0.25 mM for thiosulfate; KM=0.28 mM for cyanide;

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    hsa-miR-4330 hsa-miR-330-3p hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidMOCS3 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004792thiosulfate sulfurtransferase activity IMP17459099
    GO:0005515protein binding IPI18650437
    GO:0005524ATP binding IEA--
    GO:0016779nucleotidyltransferase activity IDA19017811
    GO:0016783sulfurtransferase activity TAS--


    MOCS3 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Molybdenum cofactor biosynthesis
    Molybdenum cofactor biosynthesis1.00
    Sulfur relay system0.33
    molybdenum cofactor biosynthesis0.67
    2Vitamin B5 (pantothenate) metabolism
    Metabolism of vitamins and cofactors0.21
    Metabolism of water-soluble vitamins and cofactors0.21
    3Metabolism
    Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for MOCS3 
        molybdenum cofactor biosynthesis

    4        Reactome Pathways for MOCS3
        Molybdenum cofactor biosynthesis
    Metabolism
    Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors


    1         Kegg Pathway  (Kegg details for MOCS3):
        Sulfur relay system

    UniProtKB/Swiss-Prot: MOCS3_HUMAN, O95396
    Pathway: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis
    Pathway: Cofactor biosynthesis; molybdopterin biosynthesis


    MOCS3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MOCS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/77 Interacting proteins for MOCS3 (O953963 ENSP000002440514) via UniProtKB, MINT, STRING, and/or I2D (see all 77)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC6Q5RKV63, ENSP000003985974I2D: score=3 STRING: ENSP00000398597
    COQ5Q5HYK33, ENSP000002885324I2D: score=2 STRING: ENSP00000288532
    EEF1A1P681043, ENSP000003300544I2D: score=2 STRING: ENSP00000330054
    NTMT1Q9BV863, ENSP000003615584I2D: score=2 STRING: ENSP00000361558
    ELP3Q9H9T33, ENSP000002563984I2D: score=1 STRING: ENSP00000256398
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002098tRNA wobble uridine modification IDA19017811
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006777Mo-molybdopterin cofactor biosynthetic process IDA15073332
    GO:0018192enzyme active site formation via L-cysteine persulfide IDA15910006


    MOCS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MOCS3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MOCS3

    1 HMDB Compound for MOCS3    About this table
    CompoundSynonyms CAS #PubMed Ids
    MolybdopterinMoCo (see all 6)73508-07-3--
    4 Novoseek chemical compound relationships for MOCS3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    molybdopterin 89.6 4 15073332 (2), 17459099 (1)
    molybdenum 83.1 2 17459099 (1), 18491921 (1)
    thiosulfate 81.4 7 17459099 (4), 15073332 (1), 18491921 (1)
    sulfur 58.3 6 17459099 (3), 18491921 (2), 15073332 (1)

    Search CenterWatch for drugs/clinical trials and news about MOCS3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MOCS3 gene: 
    NM_014484.4  

    Unigene Cluster for MOCS3:

    Molybdenum cofactor synthesis 3
    Hs.159410  [show with all ESTs]
    Unigene Representative Sequence: NM_014484
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000244051(uc002xvy.1)

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    Additional cDNA sequence: 

    AF102544.1 BC015939.2 

    2 DOTS entries:

    DT.421455  DT.91643224 

    24/48 AceView cDNA sequences (see all 48):

    BM463656 Z39705 BM549033 CA398234 AF102544 AA344580 CR599749 NM_014484 
    CA398233 BF983991 AW515066 AI942426 BC015939 BE884637 BG121538 AI570446 
    BQ067918 BQ013686 BG699802 W52284 CA488671 BX438946 BU189287 BI826026 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MOCS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTGTCAGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MOCS3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MOCS3

    SOURCE GeneReport for Unigene cluster: Hs.159410
        SABiosciences Expression via Pathway-Focused PCR Array including MOCS3: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOCS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for MOCS3 gene from 11/36 species (see all 36)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mocs31 , 5 molybdenum cofactor synthesis 31, 5 77.97(n)1
    79.78(a)1
      2 (88.50 cM)5
    693721  NM_001160330.11  NP_001153802.11 
     1682306225 
    chicken
    (Gallus gallus)
    Aves MOCS31 molybdenum cofactor synthesis 3 64.63(n)
    65.14(a)
      769390  XM_001232655.2  XP_001232656.1 
    lizard
    (Anolis carolinensis)
    Reptilia MOCS36
    --
    67(a)
    1 ↔ 1
    GL343226.1(2008941-2010158)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL871169.22   -- 70.29(n)    AL871169.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BC042324.12   -- 73.6(n)   393095  BC042324.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG130901 , 3 Mo-molybdopterin cofactor biosynthesis
    Mo-molybdopterin more3
    CG130901
    49(a)3
    53.23(n)1
    51.48(a)1
      29D43
    341871  NM_135396.21  NP_609240.21 
    worm
    (Caenorhabditis elegans)
    Secernentea F42G8.63
    moc-31
    molybdenum/thiazole biosynthesis cofactor3
    Protein MOC-31
    45(a)3
    49.58(n)1
    46.95(a)1
      IV(8130708-8131897)3
    1776071  NM_068958.41  NP_501359.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBA4(YHR111W)4
    UBA41
    Protein that activates Urm1p before its conjugation more4
    Uba4p1
    46.65(n)1
    41.75(a)1
      8(333072-334394)4
    8565111, 4  NP_011979.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CNX51 sulfurtransferase MOCS3 48.42(n)
    44.14(a)
      835604  NM_124895.2  NP_200324.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05254001 hypothetical protein 52.75(n)
    45.22(a)
      4329515  NM_001053527.1  NP_001046992.1 


    ENSEMBL Gene Tree for MOCS3 (if available)
    TreeFam Gene Tree for MOCS3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MOCS3 gene
    UBA52  

    MOCS3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MOCS3
    PGOHUM00000248388 PGOHUM00000248197


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/37 NCBI SNPs in MOCS3 are shown (see all 37    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1468943311,2
    C,--49577076(+) CACCTC/TCCCCA 1 -- ut310--------
    rs115427541,2
    C--49577149(+) TAAGAA/GATTCT 1 -- ut312Minor allele frequency- G:0.00NA 4
    rs1855273481,2
    --49577367(+) CCTCCA/GCCTCC 1 -- ut310--------
    rs1126529981,2
    C,--49577425(+) ACAGGC/TGCACG 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs1417785691,2
    --49577492(+) GTCAGG/TCTGGT 1 -- ut310--------
    rs1470864781,2
    --49577530(+) TGCCTC/TGACTT 1 -- ut310--------
    rs742746271,2
    C,--49577558(+) ACAGGC/TGTGAG 1 -- ut313Minor allele frequency- T:0.10NA EA 242
    rs21435381,2
    --49577656(+) TGTTTC/TCTTAA 1 -- ut310--------
    rs114698241,2
    C,--49577863(+) TTTAC-/TTAACATT 1 -- ut310--------
    rs1380074181,2
    --49577945(+) TGTGAA/GTGCCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MOCS3 (49575363 - 49577820 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MOCS3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MOCS3
    DNA2.0 Custom Variant and Variant Library Synthesis for MOCS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MOCS3 for disorders           About GeneDecksing

    OMIM gene information: 609277    OMIM disorders: --

    6 diseases for MOCS3:    About MalaCards
    molybdenum cofactor deficiency    choanal atresia    encephalomalacia    tuberculosis
    malaria    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for MOCS3:
    Choanal atresia

    Export disorders for MOCS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MOCS3 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with MOCS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry. (PubMed id 15910006)1, 2, 3 Matthies A.... Leimkuehler S. (2005)
    2. Site-directed mutagenesis of the active site loop of the rhodanese- like domain of the human molybdopterin synthase sulfurase MOCS3. Major differences in substrate specificity between eukaryotic and bacterial homologs. (PubMed id 17459099)1, 2, 9 Krepinsky K. and Leimkuehler S. (2007)
    3. Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans. (PubMed id 15073332)1, 2, 9 Matthies A....Leimkuhler S. (2004)
    4. A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis. (PubMed id 18650437)1, 2 Marelja Z.... Leimkuehler S. (2008)
    5. A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. (PubMed id 19017811)1, 2 Schlieker C.D....Ploegh H.L. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    8. The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins. (PubMed id 18491921)1, 9 Schmitz J.... Leimkuehler S. (2008)
    9. Mutations in the molybdenum cofactor biosynthetic genes MOCS1, MOCS2, and GEPH. (PubMed id 12754701)1, 9 Reiss J. and Johnson J.L. (2003)
    10. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27304 HGNC: 15765 AceView: MOCS3 Ensembl:ENSG00000124217 euGenes: HUgn27304
    ECgene: MOCS3 Kegg: 27304 H-InvDB: MOCS3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MOCS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MOCS3 gene:
    Search GeneIP for patents involving MOCS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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