MOCS2 Gene
protein-coding GIFtS: 59
GCID: GC05M052429
|
|
molybdenum cofactor synthesis 2
| |
Aliases
for MOCS2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Molybdenum Cofactor Synthesis 21 2 | | MOCO1-A2 3 | | MOCO11 2 3 | | MOCO1-B2 3 | | Molybdenum Cofactor Synthesis Protein 2 Large Subunit2 3 | | MOCS2A2 3 | | Molybdenum Cofactor Synthesis Protein 2 Small Subunit2 3 | | MOCS2B2 3 | | Molybdenum Cofactor Synthesis Protein 2A2 3 | | MPT Synthase Large Subunit2 3 | | Molybdenum Cofactor Synthesis Protein 2B2 3 | | MPTS2 5 | | Molybdopterin-Synthase Large Subunit2 3 | | Molybdenum Cofactor Biosynthesis Protein E2 | | Molybdopterin-Synthase Small Subunit2 3 | | Molybdopterin Synthase Catalytic Subunit2 | | Sulfur Carrier Protein MOCS2A2 3 | | Molybdopterin Synthase Sulfur Carrier Subunit2 | | MCBPE2 3 | | EC 2.8.1.123 |
Export aliases for MOCS2 gene to outside databasesPrevious GC identifers: GC05M052558 GC05M053821 GC05M052364 GC05M052409 GC05M049365 |
Summaries
for MOCS2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MOCS2:
Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and thecatalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterinsynthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping openreading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thoughtto be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus thatencode the large and small subunits. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MOC2B_HUMAN, O96007Function: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursorZ into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A intoprecursor Z to generate a dithiolene group
Gene Wiki entry for MOCS2
|
Genomic Views
for MOCS2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MOCS2 gene promoter:
S8 HOXA3 AML1a HNF-1 HNF-1A
Other transcription factors
Search SABiosciences Chromatin IP Primers for MOCS2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOCS2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q11 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11MOCS2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M052429: view genomic region
(about GC identifiers)
Start:
|
52,391,509 bp from pter |
End:
|
52,405,893 bp from pter |
Size:
|
14,385 bases |
Orientation:
|
minus strand |
|
Proteins
for MOCS2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MOC2A_HUMAN, O96033 (See
protein sequence)Recommended Name: Molybdopterin synthase sulfur carrier subunit Size: 88 amino acids; 9755 Da
Subunit: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits (By similarity)
Subcellular location: Cytoplasm, cytosol
Miscellaneous: This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B) from anoverlapping reading frame. Expression of these 2 proteins are related since a mutation that removes the start codon ofthe small subunit (MOCS2A) also impairs expression of the large subunit (MOCS2B)UniProtKB/Swiss-Prot: MOC2B_HUMAN, O96007 (See
protein sequence) Recommended Name: Molybdopterin synthase catalytic subunit Size: 188 amino acids; 20944 Da
Subunit: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits (By similarity)
Subcellular location: Cytoplasm, cytosol
Miscellaneous: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from anoverlapping reading frame. Expression of these 2 proteins are related since a mutation that removes the start codon ofthe small subunit (MOCS2A) also impairs expression of the large subunit (MOCS2B)
1 PDB 3D structure from  and Proteopedia  for MOCS2:4AP8 (3D)
Secondary accessions: Q6IAI3Explore the universe of human proteins at neXtProt for MOCS2: NX_O96007
Post-translational modifications:
C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part ofMOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS31
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O96007
MOCS2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004522.1 NP_789776.1
ENSEMBL proteins: ENSP00000355160 ENSP00000380157 ENSP00000411022 ENSP00000424267 ENSP00000426274 ENSP00000462870 ENSP00000464663 ENSP00000435326 Reactome Protein details: O96007 O96033
Human Recombinant Protein Products for MOCS2:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MOCS2 for ontologies About GeneDecksing
MOCS2 Antibody Products:
Assay Products for MOCS2: |
Protein
Domains /
Families
for MOCS2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MOCS2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O96033Graphical View of Domain Structure for InterPro Entry O96007ProtoNet protein and cluster: O96033 1 Blocks protein family: IPB003749 ThiamineS
UniProtKB/Swiss-Prot: MOC2A_HUMAN, O96033Similarity: Belongs to the moaD family. MOCS2A subfamilyUniProtKB/Swiss-Prot: MOC2B_HUMAN, O96007Similarity: Belongs to the MoaE family. MOCS2B subfamily |
Function
for MOCS2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MOC2A_HUMAN, O96033Function: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthasecomplex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfuratoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by beingthiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred toprecursor Z to form molybdopterin UniProtKB/Swiss-Prot: MOC2B_HUMAN, O96007Function: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursorZ into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A intoprecursor Z to generate a dithiolene groupCatalytic activity: Cyclic pyranopterin monophosphate + 2 [molybdopterin-synthase sulfur-carrierprotein]-Gly-NH-CH(2)-C(O)SH + H(2)O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein] Genatlas biochemistry entry for MOCS2:molybdopterine synthase,converting precursor Z (see MOCS1) to molybdopterine,predominantly expressed in heart andskeletal muscle,catalyzing the second step of the molybdenum cofactor synthesis,including the small MOCS2A and thelarge MOCS2B subunits,transcript by a single bicistronic mRNA with overlapping reading frames
Enzyme Number (IUBMB): EC 2.8.1.121
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0016740 | transferase activity |
IEA | -- | | GO:0030366 | Mo-molybdopterin synthase activity |
TAS | -- | | GO:0042802 | identical protein binding |
IEA | -- |
MOCS2 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MOCS2 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MOCS2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MOCS2 (NM_176806) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MOCS2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOCS2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOCS2 |
|
Pathways & Interactions
for MOCS2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Molybdenum cofactor biosynthesis | | | 2 | Vitamin B5 (pantothenate) metabolism | | | 3 | Metabolism | | | 4 | Folate biosynthesis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for MOCS2
4 
Reactome Pathways for MOCS2
3 
Kegg Pathways (Kegg details for MOCS2):
UniProtKB/Swiss-Prot: MOC2B_HUMAN, O96007Pathway: Cofactor biosynthesis; molybdopterin biosynthesisPathway: Cofactor biosynthesis; molybdopterin biosynthesis
MOCS2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MOCS2
5/6 Interacting proteins for MOCS2 (O960072, 3 O960332, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006766 | vitamin metabolic process |
TAS | -- | | GO:0006767 | water-soluble vitamin metabolic process |
TAS | -- | | GO:0006777 | Mo-molybdopterin cofactor biosynthetic process |
IMP | 10053004 | | GO:0032324 | molybdopterin cofactor biosynthetic process |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
MOCS2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MOCS2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MOCS2 for compounds About GeneDecksing
 Browse Tocris compounds for MOCS2
1 HMDB Compound for MOCS2 About this table
6 Novoseek chemical compound relationships for MOCS2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| molybdopterin |
97.1 |
83 |
11135669 (5), 11042213 (5), 12732628 (5), 12571227 (4) (see all 19) |
| moco |
95.8 |
9 |
11042213 (2), 11135669 (1), 18491921 (1), 10053004 (1) (see all 6) |
| moae |
95.2 |
5 |
12571227 (2), 12732628 (1) |
| molybdenum |
89.8 |
15 |
12732628 (2), 11746050 (1), 16021469 (1), 10053004 (1) (see all 8) |
| pterin |
75.9 |
2 |
12571227 (1), 12754701 (1) |
| sulfur |
64.3 |
6 |
18092812 (1), 12732628 (1), 18491921 (1) |
Search CenterWatch for drugs/clinical trials and news about MOCS2 / MOC2B
|
Transcripts
for MOCS2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MOCS2 gene (2 alternative transcripts): NM_004531.3 NM_176806.2 Unigene Cluster for MOCS2: Molybdenum cofactor synthesis 2 Hs.163645 [show with all ESTs]Unigene Representative Sequence: NM_00453110 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361377 ENST00000396954(uc003joz.3) ENST00000502402 ENST00000450852(uc011cqf.2)
ENST00000510818 ENST00000508922 ENST00000582677 ENST00000584946 ENST00000527216
ENST00000514553
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MOCS2 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MOCS2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MOCS2 (NM_176806) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MOCS2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOCS2 |
Additional cDNA sequence: AF091871.1 AF117815.1 AK312887.1 BC029287.1 BC039720.2 BC046097.1 BC095417.1 CR457172.1 10 DOTS entries: DT.99976248 DT.217911 DT.101984299 DT.100829612 DT.120799520 DT.100795301 DT.100795308 DT.120799506 DT.75107388 DT.101984301 24/273 AceView cDNA sequences (see all 273): AF117815 CD514049 CR615842 BM670346 CD370501 CR598495 BM980076 AA977271 AI056711 CB216737 AI754643 AI016715 BU623157 CR615175 BQ017886 BQ021790 BU179026 BU784450 AA022881 CA776224 AI784567 CB142016 CA411806 AA639963
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MOCS2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | - | | | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MOCS2
|
Expression
for MOCS2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MOCS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTCAAAAG
About this image
See MOCS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MOCS2
SOURCE GeneReport for Unigene cluster: Hs.163645
UniProtKB/Swiss-Prot: MOC2A_HUMAN, O96033Tissue specificity: Widely expressed. Highest levels are found in heart and skeletal muscle. Lower levels are presentin brain, kidney and pancreas. Very low levels are found in lung and peripheral blood leukocytes
UniProtKB/Swiss-Prot: MOC2B_HUMAN, O96007Tissue specificity: Highest levels are found in heart and skeletal muscle. Lower levels are present in brain, kidneyand pancreas. Very low levels are found in lung and peripheral blood leukocytes
SABiosciences Custom PCR Arrays for MOCS2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MOCS2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MOCS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOCS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOCS2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOCS2 |
Orthologs
for MOCS2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MOCS2 gene from 10/30 species (see all 30) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mocs21 , 5 |
molybdenum cofactor synthesis 21, 5 |
85.48(n)1
83.87(a)1 |
|
13 (64.61 cM)5
174341 NM_001113374.11 NP_001106845.11
1148182445 |
chicken
(Gallus gallus) |
Aves |
MOCS21 |
molybdenum cofactor synthesis 2 |
72.15(n)
73.03(a) |
|
427199 XM_001231384.2 XP_001231385.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MOCS26 |
-- |
69(a) |
1 ↔ 1 |
2(3538419-3543080) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.72982 |
Transcribed sequence with weak similarity to protein refNP_004522.1 (H.sapiens) molybdenum cofactor synthesis 2 [Homo sapiens] less |
72.59(n) |
|
BX710094.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.166602 |
Transcribed sequence with weak similarity to protein refNP_004522.1 (H.sapiens) molybdenum cofactor synthesis 2 [Homo sapiens] less |
70.27(n) |
|
BI980051.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG102383
CG425031 |
Mo-molybdopterin cofactor biosynthesis3
CG425031 |
56(a)3
55.72(n)1
57.66(a)1 |
|
96C13
86740211 NM_143083.31 NP_651340.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
T27A3.61 |
Protein T27A3.6 |
49.58(n)
43.67(a) |
|
188966 NM_059362.3 NP_491763.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT2G437601 |
Molybdopterin synthase catalytic subunit |
53.57(n)
51.43(a) |
|
818979 NM_001125046.1 NP_001118518.1 |
rice
(Oryza sativa) |
Liliopsida |
Os02g01403001 |
hypothetical protein |
44.6(n)
42.25(a) |
|
4328260 NM_001052387.2 NP_001045852.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
moaE6 |
molybdopterin synthase, large subunit |
29(a) |
1 ↔ 1 |
Chromosome(818518-818970) |
ENSEMBL Gene Tree for MOCS2 (if available)
TreeFam Gene Tree for MOCS2 (if available) |
Paralogs
for MOCS2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MOCS2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MOCS2 (52391509 - 52405893 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MOCS2
1 CNV: 38027
Human Gene Mutation Database (HGMD): MOCS2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MOCS2 |
|
Disorders
/ Diseases
for MOCS2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MOCS2 for disorders About GeneDecksing
OMIM gene information: 603708
OMIM disorders: 252150
UniProtKB/Swiss-Prot: MOC2B_HUMAN, O96007
Defects in MOCS2 are the cause of molybdenum cofactor deficiency type B (MOCOD type B) [MIM:252150]; anautosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterizedby severe neurological damage, neonatal seizures and early childhood death. The initiator codon is mutated whichresults in a complete loss of the protein Defects in MOCS2 are the cause of molybdenum cofactor deficiency type B (MOCOD type B) [MIM:252150]. MOCODtype B is an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and ischaracterized by severe neurological damage, neonatal seizures and early childhood death
11  diseases for MOCS2: About MalaCardsmolybdenum cofactor deficiency molybdenum cofactor deficiency, type b spastic quadriplegia autosomal recessive disease
verrucous carcinoma oligospermia quadriplegia spasticity
tuberculosis carcinoma mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for MOCS2:Spastic quadriplegia 1 Novoseek disease relationship for MOCS2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| molybdenum cofactor deficiency |
95.4 |
2 |
11746050 (1), 12732628 (1) |
Export disorders for MOCS2 gene to outside databases
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Publications
for MOCS2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for MOCS2 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with MOCS2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The two subunits of human molybdopterin synthase: evidence for a bicistronic messenger RNA with overlapping reading frames. (PubMed id 9889283)1, 2, 3, 9 Sloan J.... Unkles S.E. (1999)
- Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B. (PubMed id 10053004)1, 2, 3, 9 Reiss J....Zabot M.T. (1999)
- Ten novel mutations in the molybdenum cofactor genes MOCS1 and MOCS2 and in vitro characterization of a MOCS2 mutation that abolishes the binding ability of molybdopterin synthase. (PubMed id 16021469)1, 2, 9 Leimkuehler S.... Reiss J. (2005)
- Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency. (PubMed id 12732628)1, 2, 9 Leimkuehler S.... Mendel R.R. (2003)
- A novel MOCS2 mutation reveals coordinated expression of the small and large subunit of molybdopterin synthase. (PubMed id 16737835)1, 2, 9 Hahnewald R.... Reiss J. (2006)
- Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans. (PubMed id 15073332)1, 2, 9 Matthies A....Leimkuhler S. (2004)
- Human molybdopterin synthase gene: identification of a bicistronic transcript with overlapping reading frames. (PubMed id 10053003)1, 2, 9 Stallmeyer B.... Mendel R.R. (1999)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins. (PubMed id 18491921)1, 9 Schmitz J.... Leimkuehler S. (2008)
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External Searches for MOCS2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MOCS2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MOCS2 gene
(According to HUGE)
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Specialized Databases showing MOCS2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for MOCS2 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MOCS2 | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MOCS2 |
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| Patent Information for MOCS2 gene:
Search GeneIP for patents involving MOCS2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MOCS2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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