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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MOCOS Gene

protein-coding   GIFtS: 54
GCID: GC18P033767

molybdenum cofactor sulfurase
 Explore 3 diseases affiliated with
MOCOS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MOCOS    

Aliases
for MOCOS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Molybdenum Cofactor Sulfurase1 2     MoCo Sulfurase2 3
MOS1 2 3     FLJ207331
MCS2 3 5     EC 2.8.1.93
HMCS1 2     HMCS1 2

External Ids:    HGNC: 182341   Entrez Gene: 550342   Ensembl: ENSG000000756437   OMIM: 6132745   UniProtKB: Q96EN83   

Export aliases for MOCOS gene to outside databases

Previous GC identifers: GC18P032019 GC18P032021 GC18P030626


Summaries
for MOCOS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MOCOS:
MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH; MIM 607633) and aldehyde oxidase (AOX1; MIM
602841), which is required for their enzymatic activities (Ichida et al., 2001 (PubMed 11302742)).(supplied by OMIM,
Feb 2010)

UniProtKB/Swiss-Prot: MOCOS_HUMAN, Q96EN8
Function: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and
aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime

Gene Wiki entry for MOCOS


Genomic Views
for MOCOS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MOCOS gene promoter:
         c-Fos   AP-1   NRSF form 1   Lmo2   NRSF form 2   POU2F1   Ik-2   POU2F1a   ARP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MOCOS promoter sequence
   Search SABiosciences Chromatin IP Primers for MOCOS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOCOS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12   Ensembl cytogenetic band:  18q12.2   HGNC cytogenetic band: 18q12

MOCOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOCOS gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P033767:  view genomic region     (about GC identifiers)

Start:
 33,767,480 bp from pter      End:
 33,852,120 bp from pter
Size:
 84,641 bases      Orientation:
 plus strand

Proteins
for MOCOS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MOCOS_HUMAN, Q96EN8 (See protein sequence)
Recommended Name: Molybdenum cofactor sulfurase  
Size: 888 amino acids; 98120 Da
Cofactor: Pyridoxal phosphate (By similarity)
Secondary accessions: Q53GP5 Q8N3A4 Q9NWM7

Explore the universe of human proteins at neXtProt for MOCOS: NX_Q96EN8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96EN8

    • MOCOS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060417.2  
    ENSEMBL proteins: 
     ENSP00000261326  
    Reactome Protein details: Q96EN8
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MOCOS
    OriGene Protein Over-expression Lysate: MOCOS
    OriGene Custom Protein Services for MOCOS 
    GenScript Custom Purified and Recombinant Proteins Services for MOCOS
    Novus Biologicals MOCOS Protein
    Novus Biologicals MOCOS Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MOCOS

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--


    MOCOS for ontologies           About GeneDecksing



    MOCOS Antibody Products: 
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    Uscn Antibodies for MOCOS
    ThermoFisher Antibodies for MOCOS

    Assay Products for MOCOS: 
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    Uscn ELISAs and CLIAs for MOCOS

    Protein Domains /
    Families
    for MOCOS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MOCOS for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR005303 MOSC_N
     IPR005302 MoCF_Sase_C
     IPR015422 PyrdxlP-dep_Trfase_major_sub2
     IPR015424 PyrdxlP-dep_Trfase
     IPR011037 Pyrv_Knase-like_insert_dom

    Graphical View of Domain Structure for InterPro Entry Q96EN8

    ProtoNet protein and cluster: Q96EN8

    2 Blocks protein families:
    IPB000192 Aminotransferase
    IPB005302 MOSC domain


    UniProtKB/Swiss-Prot: MOCOS_HUMAN, Q96EN8
    Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily
    Similarity: Contains 1 MOSC domain


    Function
    for MOCOS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MOCOS_HUMAN, Q96EN8
    Function: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and
    aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.
    In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime
    Catalytic activity: Molybdenum cofactor + L-cysteine + 2 H(+) = thio-molybdenum cofactor + L-alanine + H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=15 uM for benzamidoxime; Vmax=0.24 nmol/min/mg enzyme;

    Enzyme Number (IUBMB): EC 2.8.1.91

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOCOS
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MOCOS
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MOCOS (see all 7)
    OriGene shRNA RFP: MOCOS
    OriGene siRNA: MOCOS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOCOS

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MOCOS

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MOCOS (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MOCOS
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MOCOS (NM_017947)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOCOS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOCOS 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MOCOS
    Search LifeMap BioReagents cell lines for MOCOS

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOCOS

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008265Mo-molybdopterin cofactor sulfurase activity TAS--
    GO:0016740transferase activity IEA--
    GO:0030151molybdenum ion binding IEA--
    GO:0030170pyridoxal phosphate binding IEA--


    MOCOS for ontologies           About GeneDecksing



    Pathways & Interactions
    for MOCOS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Vitamin B5 (pantothenate) metabolism
    		Metabolism of vitamins and cofactors0.21
    		Metabolism of water-soluble vitamins and cofactors0.21
    2Metabolism
    		Metabolism1.00
    3thio-molybdenum cofactor biosynthesis
    		thio-molybdenum cofactor biosynthesis1.00
    4Molybdenum cofactor biosynthesis
    		Molybdenum cofactor biosynthesis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for MOCOS 
        thio-molybdenum cofactor biosynthesis

    4        Reactome Pathways for MOCOS
        Molybdenum cofactor biosynthesis
    Metabolism
    Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors



    MOCOS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOCOS

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for MOCOS (Q96EN83 ENSP000002613264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    PARVAQ9NVD73I2D: score=1 
    GPHNENSP000003030194STRING: ENSP00000303019
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006777Mo-molybdopterin cofactor biosynthetic process IEA--
    GO:0032324molybdopterin cofactor biosynthetic process TAS--
    GO:0043545molybdopterin cofactor metabolic process IMP11302742


    MOCOS for ontologies           About GeneDecksing



    Drugs & Compounds
    for MOCOS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MOCOS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MOCOS

    3 HMDB Compounds for MOCOS    About this table
    CompoundSynonyms CAS #PubMed Ids
    MolybdenumMo (see all 7)7439-98-7--
    MolybdopterinMoCo (see all 6)73508-07-3--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--

    1 DrugBank Compound for MOCOS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor16784786 11886751 15561708 11553608

    4 Novoseek chemical compound relationships for MOCOS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    moco 89.2 2 17368066 (2)
    molybdenum 81.8 13 11886751 (3), 11302742 (2), 17368066 (2), 16973608 (2) (see all 5)
    sulfur 56.1 3 11302742 (1), 17368066 (1)
    cysteine 31.5 2 11886751 (1), 17368066 (1)

    Search CenterWatch for drugs/clinical trials and news about MOCOS 

    Transcripts
    for MOCOS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MOCOS gene: 
    NM_017947.2  

    Unigene Cluster for MOCOS:

    Molybdenum cofactor sulfurase
    Hs.405028  [show with all ESTs]
    Unigene Representative Sequence: NM_017947
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261326(uc002kzq.4) ENST00000588132

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOCOS
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MOCOS
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MOCOS (see all 7)
    OriGene shRNA RFP: MOCOS
    OriGene siRNA: MOCOS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOCOS
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MOCOS
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MOCOS (NM_017947)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOCOS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOCOS 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MOCOS
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MOCOS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOCOS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOCOS

    Additional cDNA sequence: 

    AK000740.1 AK222886.1 AL834481.1 BC012079.1 

    2 DOTS entries:

    DT.40297105  DT.95262122 

    24/37 AceView cDNA sequences (see all 37):

    BI334738 BG437910 BQ931455 CF264922 BX280861 BM798406 BC012079 BQ229917 
    BI260498 BI253752 BI333663 BV199123 AA689533 NM_017947 BU633672 AK000740 
    BU601942 AL834481 BU153039 BI335548 BQ015014 BG220971 BQ013643 BE549243 

    GeneLoc Exon Structure


    Expression
    for MOCOS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MOCOS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MOCOS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleMature Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage

    See MOCOS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MOCOS

    SOURCE GeneReport for Unigene cluster: Hs.405028
        SABiosciences Custom PCR Arrays for MOCOS
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOCOS

    Orthologs
    for MOCOS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MOCOS gene from 9/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mocos1 , 5 molybdenum cofactor sulfurase1, 5 80.2(n)1
    76.78(a)1    		   18 (13.18 cM)5
    685911  NM_026779.11  NP_081055.11 
     246536915 
    chicken
    (Gallus gallus)    		 Aves MOCOS1 molybdenum cofactor sulfurase 65.95(n)
    64.56(a)    		   420964  XM_419048.3  XP_419048.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    MOCOS6
    		 --
    		 70(a)
    55(a)
    		 possible ortholog
    1 ↔ 1
    		 GL344100.1(50054-61934)
    6(57059385-57091345)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX760843.12   -- 71.18(n)    BX760843.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii 570578482   -- 76.74(n)    57057848 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mal1 maroon-like 51.41(n)
    46.52(a)    		   33045  NM_078699.2  NP_523423.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea mocs-11 Protein MOCS-1 46.15(n)
    40.62(a)    		   187534  NM_078151.2  NP_510552.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ABA31 Molybdenum cofactor sulfurase 46.4(n)
    39.06(a)    		   838224  NM_101519.2  NP_564001.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 5)    		 expressed protein
    molybdenum cofactor sulfurase, putative, expressed...
    (see all 5)    		 9(a)
    35(a)
    (see all 5)    		 possible ortholog
    1 ↔ 1
    (see all 5)    		 3(31708833-31714769)
    6(27748133-27755344)


    ENSEMBL Gene Tree for MOCOS (if available)
    TreeFam Gene Tree for MOCOS (if available) 

    Paralogs
    for MOCOS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MOCOS gene
    MARC22  MARC12  

    MOCOS for paralogs           About GeneDecksing



    Genomic Variants
    for MOCOS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1568 NCBI SNPs in MOCOS are shown (see all 1568)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1491980611,2
    		C,Fother33795659(+) ACACCA/G/TGGGAG 3 R G W mis12NA EU 5869
    rs1498245481,2
    		--33765593(+) TGCCCG/TTGTGC 1 -- us2k10--------
    rs1479178071,2
    		--33765607(+) TTATTC/TTGCCT 1 -- us2k10--------
    rs1883026481,2
    		--33765652(+) CCTCCC/TAGATC 1 -- us2k10--------
    rs1400927901,2
    		--33765686(+) CAGGAC/GAGGTA 1 -- us2k10--------
    rs1808218481,2
    		--33765991(+) CTGAGC/GAATAT 1 -- us2k10--------
    rs6078561,2
    		C,F,O,A,H,--33766007(+) CCTGGG/CCATGG 1 -- us2k117Minor allele frequency- C:0.46MN EA NS NA WA 2824
    rs1847123691,2
    		--33766195(+) CTAGGA/GCATCT 1 -- us2k10--------
    rs739467881,2
    		C,F,--33766367(+) GAGTTA/GTCTCC 1 -- us2k14Minor allele frequency- G:0.10WA NA 242
    rs1450990091,2
    		--33766596(+) CGCTCA/CGCACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MOCOS (33767480 - 33852120 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MOCOS
         1 CNV: 5903
    Human Gene Mutation Database (HGMD): MOCOS

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MOCOS
    DNA2.0 Custom Variant and Variant Library Synthesis for MOCOS

    Disorders / Diseases
    for MOCOS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MOCOS for disorders           About GeneDecksing

    OMIM gene information: 613274    OMIM disorders: --

    UniProtKB/Swiss-Prot: MOCOS_HUMAN, Q96EN8
  • Defects in MOCOS are the cause of xanthinuria type 2 (XU2) [MIM:603592]. Xanthinuria is characterized by
    • excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is
    strikingly diminished in serum and urine. In addition, patient suffering of XU2 cannot metabolize allopurinol into
    oxypurinol due to dual deficiency of xanthine dehydrogenase and aldehyde oxidase

    3 diseases for MOCOS:    About MalaCards
    xanthinuria    xanthinuria type 2    inflammatory bowel disease

    1 Novoseek disease relationship for MOCOS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xanthinuria, type ii 99 6 11302742 (3), 17368066 (1)

    Human Genome Epidemiology (HuGE) Navigator: MOCOS (1 document)

    Export disorders for MOCOS gene to outside databases

    Publications
    for MOCOS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MOCOS gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with MOCOS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation of human molybdenum cofactor sulfurase gene is responsible to classical xanthinuria type II. (PubMed id 11302742)1, 2, 3, 9 Ichida K.... Nishino T. (2001)
    2. Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the human molybdenum cofactor sulfurase (HMCS) associated with type II classical xanthinuria. (PubMed id 17368066)1, 2, 9 Peretz H.... Landau D. (2007)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification of a new point mutation in the human molybdenum cofactor sulferase gene that is responsible for xanthinuria type II. (PubMed id 14624414)1, 2 Yamamoto T.... Hada T. (2003)
    6. MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases. (PubMed id 11886751)7, 9 Anantharaman V. and Aravind L. (2002)
    7. Novel pharmacogenetic markers for treatment outcome i n azathioprine-treated inflammatory bowel disease. (PubMed id 19500084)1, 9 Smith M.A....Sanderson J.D. (2009)
    8. Identification of the missing component in the mitochondrial benzamidoxime prodrug converting system as a novel molybdenum enzyme. (PubMed id 16973608)2, 9 Havemeyer A.... Clement B. (2006)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    External Searches for MOCOS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MOCOS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55034 HGNC: 18234 AceView: MOCOS Ensembl:ENSG00000075643 euGenes: HUgn55034
    ECgene: MOCOS H-InvDB: MOCOS

    Other Databases showing MOCOS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MOCOS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MOCOS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MOCOS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MOCOS gene:
    Search GeneIP for patents involving MOCOS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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