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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MOCOS Gene

protein-coding   GIFtS: 55
GCID: GC18P033767

Molybdenum Cofactor Sulfurase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Molybdenum Cofactor Sulfurase1 2     HMCS2
MCS2 3 5     EC 2.8.1.93
MoCo Sulfurase2 3     hMCS3
MOS2 3     

External Ids:    HGNC: 182341   Entrez Gene: 550342   Ensembl: ENSG000000756437   OMIM: 6132745   UniProtKB: Q96EN83   

Export aliases for MOCOS gene to outside databases

Previous GC identifers: GC18P032019 GC18P032021 GC18P030626


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MOCOS Gene:
MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH; MIM 607633) and aldehyde oxidase (AOX1;
MIM 602841), which is required for their enzymatic activities (Ichida et al., 2001 (PubMed 11302742)).(supplied
by OMIM, Feb 2010)

GeneCards Summary for MOCOS Gene: 
MOCOS (molybdenum cofactor sulfurase) is a protein-coding gene. Diseases associated with MOCOS include xanthinuria type 2, and inflammatory bowel disease, and among its related super-pathways are Metabolism of water-soluble vitamins and cofactors and molybdenum cofactor biosynthesis. GO annotations related to this gene include molybdenum ion binding and pyridoxal phosphate binding. An important paralog of this gene is MARC2.

UniProtKB/Swiss-Prot: MOCOS_HUMAN, Q96EN8
Function: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase
(XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom
in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime

Gene Wiki entry for MOCOS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.2  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MOCOS gene promoter:
         c-Fos   AP-1   NRSF form 1   Lmo2   NRSF form 2   POU2F1   Ik-2   POU2F1a   ARP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOCOS promoter sequence
   Search SABiosciences Chromatin IP Primers for MOCOS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOCOS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12   Ensembl cytogenetic band:  18q12.2   HGNC cytogenetic band: 18q12

MOCOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOCOS gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P033767:  view genomic region     (about GC identifiers)

Start:
33,767,480 bp from pter      End:
33,852,120 bp from pter
Size:
84,641 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MOCOS_HUMAN, Q96EN8 (See protein sequence)
Recommended Name: Molybdenum cofactor sulfurase  
Size: 888 amino acids; 98120 Da
Cofactor: Pyridoxal phosphate (By similarity)
Secondary accessions: Q53GP5 Q8N3A4 Q9NWM7

Explore the universe of human proteins at neXtProt for MOCOS: NX_Q96EN8

Explore proteomics data for MOCOS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96EN8

  • MOCOS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MOCOS Protein Expression
    REFSEQ proteins: NP_060417.2  
    ENSEMBL proteins: 
     ENSP00000261326  
    Reactome Protein details: Q96EN8
    Human Recombinant Protein Products for MOCOS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MOCOS
    OriGene Protein Over-expression Lysate for MOCOS
    OriGene MassSpec for MOCOS 
    OriGene Custom Protein Services for MOCOS
    GenScript Custom Purified and Recombinant Proteins Services for MOCOS
    Novus Biologicals MOCOS Protein
    Novus Biologicals MOCOS Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MOCOS 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--

    MOCOS for ontologies           About GeneDecksing



    MOCOS Antibody Products: 
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    Novus Biologicals MOCOS Antibodies
    Abcam antibodies for MOCOS
    Cloud-Clone Corp. Antibodies for MOCOS 
    ThermoFisher Antibodies for MOCOS
    Search LSBio for Antibodies for MOCOS 

    Assay Products for MOCOS: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MOCOS
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MOCOS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MOCOS 
    Cloud-Clone Corp. CLIAs for MOCOS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR005303 MOSC_N
     IPR005302 MoCF_Sase_C
     IPR015422 PyrdxlP-dep_Trfase_major_sub2
     IPR015424 PyrdxlP-dep_Trfase
     IPR011037 Pyrv_Knase-like_insert_dom

    Graphical View of Domain Structure for InterPro Entry Q96EN8

    ProtoNet protein and cluster: Q96EN8

    2 Blocks protein domains:
    IPB000192 Aminotransferase
    IPB005302 MOSC domain


    UniProtKB/Swiss-Prot: MOCOS_HUMAN, Q96EN8
    Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily
    Similarity: Contains 1 MOSC domain


    MOCOS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOCOS_HUMAN, Q96EN8
    Function: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase
    (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom
    in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime
    Catalytic activity: Molybdenum cofactor + L-cysteine + 2 H(+) = thio-molybdenum cofactor + L-alanine + H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=15 uM for benzamidoxime; Vmax=0.24 nmol/min/mg enzyme;

         Enzyme Number (IUBMB): EC 2.8.1.91

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0008265Mo-molybdopterin cofactor sulfurase activity TAS--
    GO:0016740transferase activity IEA--
    GO:0030151molybdenum ion binding IEA--
    GO:0030170pyridoxal phosphate binding IEA--
         
    MOCOS for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MOCOS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MOCOS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MOCOS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MOCOS 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOCOS
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MOCOS
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MOCOS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOCOS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MOCOS
    Sirion Biotech Customized adenovirus for overexpression of MOCOS

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MOCOS (see all 6)
    OriGene ORF clones in mouse, rat for MOCOS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MOCOS (NM_017947)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOCOS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOCOS
    Sirion Biotech Customized lentivirus for stable overexpression of MOCOS 
                         Customized lentivirus expression plasmids for stable overexpression of MOCOS 

    Cell Line
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    Search LifeMap BioReagents cell lines for MOCOS
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOCOS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MOCOS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors1.00
    Metabolism of vitamins and cofactors1.00
    2Molybdenum cofactor biosynthesis
    Molybdenum cofactor biosynthesis0.67
    3Metabolism
    Metabolism0.40
    4thio-molybdenum cofactor biosynthesis
    thio-molybdenum cofactor biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MOCOS
        thio-molybdenum cofactor biosynthesis

    4        Reactome Pathways for MOCOS
        Molybdenum cofactor biosynthesis
    Metabolism
    Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors



    MOCOS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOCOS

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for MOCOS (Q96EN83 ENSP000002613264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    PARVAQ9NVD73I2D: score=1 
    GPHNENSP000003030194STRING: ENSP00000303019
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006777Mo-molybdopterin cofactor biosynthetic process IEA--
    GO:0008152metabolic process ----
    GO:0032324molybdopterin cofactor biosynthetic process TAS--

    MOCOS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MOCOS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MOCOS

    3 HMDB Compounds for MOCOS    About this table
    CompoundSynonyms CAS #PubMed Ids
    MolybdenumMo (see all 7)7439-98-7--
    MolybdopterinMoCo (see all 6)73508-07-3--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--

    1 DrugBank Compound for MOCOS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor16784786 11886751 15561708 11553608

    4 Novoseek inferred chemical compound relationships for MOCOS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    moco 89.2 2 17368066 (2)
    molybdenum 81.8 13 11886751 (3), 11302742 (2), 17368066 (2), 16973608 (2) (see all 5)
    sulfur 56.1 3 11302742 (1), 17368066 (1)
    cysteine 31.5 2 11886751 (1), 17368066 (1)

    Search CenterWatch for drugs/clinical trials and news about MOCOS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MOCOS gene: 
    NM_017947.2  

    Unigene Cluster for MOCOS:

    Molybdenum cofactor sulfurase
    Hs.405028  [show with all ESTs]
    Unigene Representative Sequence: NM_017947
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261326(uc002kzq.4) ENST00000588132
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOCOS
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MOCOS
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MOCOS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOCOS
    Clone
    Products:
         
    OriGene clones in human, mouse for MOCOS (see all 6)
    OriGene ORF clones in mouse, rat for MOCOS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MOCOS (NM_017947)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOCOS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOCOS
    Sirion Biotech Customized lentivirus for stable overexpression of MOCOS 
                         Customized lentivirus expression plasmids for stable overexpression of MOCOS 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MOCOS
    OriGene qSTAR qPCR primer pairs in human, mouse for MOCOS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MOCOS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOCOS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOCOS

    Additional mRNA sequence: 

    AK000740.1 AK222886.1 AL834481.1 BC012079.1 

    2 DOTS entries:

    DT.40297105  DT.95262122 

    24/37 AceView cDNA sequences (see all 37):

    AL834481 BI253752 BU633672 BC012079 BU601942 CF264922 BV199123 AA689533 
    BI335548 BX280861 BI333663 BQ931455 AK000740 BQ015014 BM798406 BI260498 
    BG437910 BI334738 BU153039 NM_017947 BQ229917 BP355720 BE549243 CF529964 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MOCOS expression in normal human tissues (normalized intensities)      MOCOS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MOCOS Expression
    About this image


    MOCOS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Myoblasts Mandibular Arch Muscles
             Human Skeletal Muscle Myoblast (HSkMM)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
             Umbilical cord blood-derived endothelial progenitor cells
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Uterus (Reproductive System)
             CERVIX   
     
     Lower Urinary Tract (Urinary System)
             Human Urothelial Cells (HUC)   

    See MOCOS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MOCOS

    SOURCE GeneReport for Unigene cluster: Hs.405028
        SABiosciences Custom PCR Arrays for MOCOS
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MOCOS
    OriGene qSTAR qPCR primer pairs in human, mouse for MOCOS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MOCOS
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOCOS
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOCOS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOCOS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MOCOS gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mocos1 , 5 molybdenum cofactor sulfurase1, 5 80.2(n)1
    76.78(a)1
      18 (13.18 cM)5
    685911  NM_026779.11  NP_081055.11 
     246536915 
    chicken
    (Gallus gallus)
    Aves MOCOS1 molybdenum cofactor sulfurase 65.95(n)
    64.56(a)
      420964  XM_419048.3  XP_419048.3 
    lizard
    (Anolis carolinensis)
    Reptilia MOCOS6
    Uncharacterized protein
    55(a)
    1 ↔ 1
    6(57059385-57092492)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX760843.12   -- 71.18(n)    BX760843.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570578482   -- 76.74(n)    57057848 
    fruit fly
    (Drosophila melanogaster)
    Insecta mal1 maroon-like 51.41(n)
    46.52(a)
      33045  NM_078699.2  NP_523423.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mocs-11 Protein MOCS-1 46.15(n)
    40.62(a)
      187534  NM_078151.2  NP_510552.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ABA31 Molybdenum cofactor sulfurase 46.4(n)
    39.06(a)
      838224  NM_101519.2  NP_564001.1 


    ENSEMBL Gene Tree for MOCOS (if available)
    TreeFam Gene Tree for MOCOS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MOCOS gene
    MARC22  MARC12  

    MOCOS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1966 SNPs in MOCOS are shown (see all 1966)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0275284
    Xanthinuria 2 (XU2)4--see VAR_0275282 A P mis40--------
    VAR_0275334
    Xanthinuria 2 (XU2)4--see VAR_0275332 T I mis40--------
    VAR_0458994
    Xanthinuria 2 (XU2)4--see VAR_0458992 R C mis40--------
    rs1491980611,2
    C,Funtested133795659(+) ACACCA/G/TGGGAG 2 R G mis12NA EU 5869
    rs1498245481,2
    C--33765593(+) TGCCCG/TTGTGC 1 -- us2k10--------
    rs1479178071,2
    --33765607(+) TTATTC/TTGCCT 1 -- us2k10--------
    rs1883026481,2
    --33765652(+) CCTCCC/TAGATC 1 -- us2k10--------
    rs1400927901,2
    C--33765686(+) CAGGAC/GAGGTA 1 -- us2k10--------
    rs1808218481,2
    --33765991(+) CTGAGC/GAATAT 1 -- us2k10--------
    rs6078561,2
    C,F,O,A,H--33766007(+) CCTGGG/CCATGG 1 -- us2k117Minor allele frequency- C:0.46MN EA NS NA WA 2824

    HapMap Linkage Disequilibrium report for MOCOS (33767480 - 33852120 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MOCOS:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv987550CNV Deletion20482838
    esv2667651CNV Deletion23128226
    esv268498CNV Insertion20981092
    nsv130568CNV Loss16902084
    nsv522803CNV Loss19592680
    nsv909539CNV Gain21882294


    Human Gene Mutation Database (HGMD): MOCOS
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MOCOS
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613274    OMIM disorders: --

    UniProtKB/Swiss-Prot: MOCOS_HUMAN, Q96EN8
  • Xanthinuria 2 (XU2) [MIM:603592]: A disorder characterized by excretion of very large amounts of xanthine
    in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. In
    addition, patients suffering of xanthinuria 2 cannot metabolize allopurinol into oxypurinol due to dual
    deficiency of xanthine dehydrogenase and aldehyde oxidase. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 2 diseases for MOCOS:    About MalaCards
    xanthinuria type 2    inflammatory bowel disease


    MOCOS for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MOCOS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xanthinuria, type ii 99 6 11302742 (3), 17368066 (1)

    Genetic Association Database (GAD): MOCOS
    Human Genome Epidemiology (HuGE) Navigator: MOCOS (1 document)

    Export disorders for MOCOS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MOCOS gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with MOCOS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation of human molybdenum cofactor sulfurase gene is responsible to classical xanthinuria type II. (PubMed id 11302742)1, 2, 3, 9 Ichida K.... Nishino T. (2001)
    2. Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the human molybdenum cofactor sulfurase (HMCS) associated with type II classical xanthinuria. (PubMed id 17368066)1, 2, 9 Peretz H.... Landau D. (2007)
    3. Novel pharmacogenetic markers for treatment outcome i n azathioprine-treated inflammatory bowel disease. (PubMed id 19500084)1, 4, 9 Smith M.A....Sanderson J.D. (2009)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Identification of a new point mutation in the human molybdenum cofactor sulferase gene that is responsible for xanthinuria type II. (PubMed id 14624414)1, 2 Yamamoto T.... Hada T. (2003)
    7. MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases. (PubMed id 11886751)7, 9 Anantharaman V. and Aravind L. (2002)
    8. Identification of the missing component in the mitochondrial benzamidoxime prodrug converting system as a novel molybdenum enzyme. (PubMed id 16973608)2, 9 Havemeyer A.... Clement B. (2006)
    9. Polymorphism of genes involved in purine metabolism (X DH, AOX1, MOCOS) in kidney transplant recipients receiving azathioprine. (PubMed id 22495427)1 Kurzawski M....Drozdzik M. (2012)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55034 HGNC: 18234 AceView: MOCOS Ensembl:ENSG00000075643 euGenes: HUgn55034
    ECgene: MOCOS H-InvDB: MOCOS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MOCOS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MOCOS gene:
    Search GeneIP for patents involving MOCOS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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