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Aliases for MOBP Gene

Aliases for MOBP Gene

  • Myelin-Associated Oligodendrocyte Basic Protein 2 3

External Ids for MOBP Gene

Previous GeneCards Identifiers for MOBP Gene

  • GC03U990052
  • GC03P038742
  • GC03P039322
  • GC03P039504
  • GC03P039469
  • GC03P039484

Summaries for MOBP Gene

GeneCards Summary for MOBP Gene

MOBP (Myelin-Associated Oligodendrocyte Basic Protein) is a Protein Coding gene. Diseases associated with MOBP include substance abuse and multiple sclerosis, disease progression, modifier of. GO annotations related to this gene include Rab GTPase binding and structural constituent of myelin sheath.

UniProtKB/Swiss-Prot for MOBP Gene

  • May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOBP Gene

Genomics for MOBP Gene

Regulatory Elements for MOBP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MOBP Gene

Chromosome:
3
Start:
39,467,198 bp from pter
End:
39,529,497 bp from pter
Size:
62,300 bases
Orientation:
Plus strand

Genomic View for MOBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MOBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOBP Gene

Proteins for MOBP Gene

  • Protein details for MOBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13875-MOBP_HUMAN
    Recommended name:
    Myelin-associated oligodendrocyte basic protein
    Protein Accession:
    Q13875
    Secondary Accessions:
    • A8K2C2
    • G5E945
    • Q13874
    • Q6DHZ6
    • Q8TBJ1

    Protein attributes for MOBP Gene

    Size:
    183 amino acids
    Molecular mass:
    20959 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MOBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOBP Gene

Proteomics data for MOBP Gene at MOPED

Post-translational modifications for MOBP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for MOBP Gene

Domains & Families for MOBP Gene

Protein Domains for MOBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MOBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MOBP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MOBP Gene

Function for MOBP Gene

Molecular function for MOBP Gene

GENATLAS Biochemistry:
myelin-associated oligodendrocytic basic protein,with two isoforms
UniProtKB/Swiss-Prot Function:
May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.

Gene Ontology (GO) - Molecular Function for MOBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019911 structural constituent of myelin sheath IEA --
genes like me logo Genes that share ontologies with MOBP: view

Phenotypes for MOBP Gene

MGI mutant phenotypes for MOBP:
inferred from 2 alleles
GenomeRNAi human phenotypes for MOBP:
genes like me logo Genes that share phenotypes with MOBP: view

Animal Models for MOBP Gene

MGI Knock Outs for MOBP:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MOBP Gene

Localization for MOBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOBP Gene

Cytoplasm, perinuclear region. Note=Present in the major dense line of CNS myelin. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOBP Gene COMPARTMENTS Subcellular localization image for MOBP gene
Compartment Confidence
mitochondrion 2

Gene Ontology (GO) - Cellular Components for MOBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0043209 myelin sheath IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MOBP: view

Pathways & Interactions for MOBP Gene

SuperPathways for MOBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with MOBP: view

No data available for Pathways by source and SIGNOR curated interactions for MOBP Gene

Drugs & Compounds for MOBP Gene

(1) Drugs for MOBP Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cocaine Approved, Illicit Pharma 441

(1) Additional Compounds for MOBP Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2,3-Cyclic nucleotide
genes like me logo Genes that share compounds with MOBP: view

Transcripts for MOBP Gene

Unigene Clusters for MOBP Gene

Myelin-associated oligodendrocyte basic protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MOBP Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g
SP1: - - - - -
SP2: - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - -
SP8: - - - - - - - - - -
SP9:
SP10: - - - - - - - - - - - - -
SP11: - - - - - -
SP12: - - -
SP13: - - - - - - - - - - -
SP14:

Relevant External Links for MOBP Gene

GeneLoc Exon Structure for
MOBP
ECgene alternative splicing isoforms for
MOBP

Expression for MOBP Gene

mRNA expression in normal human tissues for MOBP Gene

mRNA differential expression in normal tissues according to GTEx for MOBP Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x23.2), Brain - Substantia nigra (x7.9), and Brain - Hippocampus (x4.6).

Protein differential expression in normal tissues from HIPED for MOBP Gene

This gene is overexpressed in Brain (50.3), Frontal cortex (11.9), and Spinal cord (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MOBP Gene



SOURCE GeneReport for Unigene cluster for MOBP Gene Hs.121333

genes like me logo Genes that share expression patterns with MOBP: view

Protein tissue co-expression partners for MOBP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MOBP Gene

Orthologs for MOBP Gene

This gene was present in the common ancestor of mammals.

Orthologs for MOBP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MOBP 35
  • 86.67 (n)
  • 89.33 (a)
MOBP 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOBP 35
  • 90.62 (n)
  • 91.25 (a)
MOBP 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mobp 35
  • 83.83 (n)
  • 84.62 (a)
Mobp 16
Mobp 36
  • 41 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MOBP 35
  • 99.64 (n)
  • 99.45 (a)
MOBP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mobp 35
  • 81.48 (n)
  • 87.65 (a)
Species with no ortholog for MOBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MOBP Gene

ENSEMBL:
Gene Tree for MOBP (if available)
TreeFam:
Gene Tree for MOBP (if available)

Paralogs for MOBP Gene

(1) SIMAP similar genes for MOBP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MOBP: view

No data available for Paralogs for MOBP Gene

Variants for MOBP Gene

Sequence variations from dbSNP and Humsavar for MOBP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2542 -- 39,525,858(+) TCTCT(G/T)TAGAA nc-transcript-variant
rs2677 -- 39,525,056(+) ATAAT(G/T)CAATA nc-transcript-variant
rs481523 -- 39,477,849(+) aaaat(A/T)aaaaa intron-variant
rs481718 -- 39,527,470(+) GTTTC(G/T)CTCTT nc-transcript-variant
rs482495 -- 39,498,924(+) GAGTG(A/G)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOBP Gene

Variant ID Type Subtype PubMed ID
nsv520957 CNV Loss 19592680
esv2425951 CNV Deletion 19546169
esv2725179 CNV Deletion 23290073
nsv236980 CNV Loss 16902084
esv1395867 CNV Insertion 17803354
esv1680226 CNV Insertion 17803354
dgv1450e1 CNV Complex 17122850

Variation tolerance for MOBP Gene

Gene Damage Index Score: 0.28; 6.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOBP Gene

HapMap Linkage Disequilibrium report
MOBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOBP Gene

Disorders for MOBP Gene

MalaCards: The human disease database

(3) MalaCards diseases for MOBP Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
substance abuse
  • substance abuse problem
multiple sclerosis, disease progression, modifier of
  • multiple sclerosis 1
schizophrenia
  • schizophrenia 12
- elite association
Search MOBP in MalaCards View complete list of genes associated with diseases

Relevant External Links for MOBP

Genetic Association Database (GAD)
MOBP
Human Genome Epidemiology (HuGE) Navigator
MOBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOBP
genes like me logo Genes that share disorders with MOBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOBP Gene

Publications for MOBP Gene

  1. Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin. (PMID: 7989345) Yamamoto Y. … Sakoda S. (J. Biol. Chem. 1994) 2 23 67
  2. The myelin-associated oligodendrocytic basic protein (MOBP) as a relevant primary target autoantigen in multiple sclerosis. (PMID: 19683076) Kaushansky N. … Ben-Nun A. (Autoimmun Rev 2010) 23 67
  3. Immune responses to JC virus in patients with multiple sclerosis treated with natalizumab: a cross-sectional and longitudinal study. (PMID: 20117055) Jilek S. … Du Pasquier R.A. (Lancet Neurol 2010) 23 67
  4. Discoidin domain receptor 1, a tyrosine kinase receptor, is upregulated in an experimental model of remyelination and during oligodendrocyte differentiation in vitro. (PMID: 18836851) Franco-Pons N. … Vilella E. (J. Mol. Neurosci. 2009) 23 67
  5. Cathepsin G is differentially expressed in primary human antigen-presenting cells. (PMID: 19036358) Stoeckle C. … Burster T. (Cell. Immunol. 2009) 23 67

Products for MOBP Gene

Sources for MOBP Gene

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