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Aliases for MOBP Gene

Aliases for MOBP Gene

  • Myelin-Associated Oligodendrocyte Basic Protein 2 3 5

External Ids for MOBP Gene

Previous GeneCards Identifiers for MOBP Gene

  • GC03U990052
  • GC03P038742
  • GC03P039322
  • GC03P039504
  • GC03P039469
  • GC03P039484

Summaries for MOBP Gene

GeneCards Summary for MOBP Gene

MOBP (Myelin-Associated Oligodendrocyte Basic Protein) is a Protein Coding gene. Diseases associated with MOBP include Substance Abuse and Corticobasal Degeneration. GO annotations related to this gene include Rab GTPase binding and structural constituent of myelin sheath. An important paralog of this gene is MYRIP.

UniProtKB/Swiss-Prot for MOBP Gene

  • May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.

Additional gene information for MOBP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOBP Gene

Genomics for MOBP Gene

Regulatory Elements for MOBP Gene

Enhancers for MOBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H039145 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -316.1 -316102 10.7 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF207 GORASP1 SNORA62 TTC21A CX3CR1 OXSR1 WDR48 CSRNP1 XIRP1 MOBP ACVR2B-AS1
GH03H039490 0.6 dbSUPER 27.4 +25.3 25313 4 ATF1 ZNF629 CREB1 ATF7 CREM ATF2 MOBP RPSA NFU1P1
GH03H039458 0.9 FANTOM5 dbSUPER 18.2 -8.4 -8366 0.3 ZNF316 NFYB MAFG EMSY MOBP CX3CR1 RPSA SNORA6 TTC21A LOC105377038
GH03H039461 0.4 dbSUPER 37.6 -1.9 -1895 7 EZH2 MOBP CX3CR1 RPSA LOC105377038
GH03H039479 0.5 dbSUPER 28.3 +13.6 13577 3.1 ZNF316 MAFG MAFK MOBP RPSA NFU1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MOBP on UCSC Golden Path with GeneCards custom track

Genomic Locations for MOBP Gene

Genomic Locations for MOBP Gene
chr3:39,467,198-39,529,497
(GRCh38/hg38)
Size:
62,300 bases
Orientation:
Plus strand
chr3:39,508,689-39,570,970
(GRCh37/hg19)

Genomic View for MOBP Gene

Genes around MOBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOBP Gene

Proteins for MOBP Gene

  • Protein details for MOBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13875-MOBP_HUMAN
    Recommended name:
    Myelin-associated oligodendrocyte basic protein
    Protein Accession:
    Q13875
    Secondary Accessions:
    • A8K2C2
    • G5E945
    • Q13874
    • Q6DHZ6
    • Q8TBJ1

    Protein attributes for MOBP Gene

    Size:
    183 amino acids
    Molecular mass:
    20959 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MOBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOBP Gene

Post-translational modifications for MOBP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MOBP Gene

Domains & Families for MOBP Gene

Gene Families for MOBP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MOBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MOBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MOBP: view

No data available for UniProtKB/Swiss-Prot for MOBP Gene

Function for MOBP Gene

Molecular function for MOBP Gene

GENATLAS Biochemistry:
myelin-associated oligodendrocytic basic protein,with two isoforms
UniProtKB/Swiss-Prot Function:
May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.

Phenotypes From GWAS Catalog for MOBP Gene

Gene Ontology (GO) - Molecular Function for MOBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0017022 myosin binding IBA --
GO:0017137 Rab GTPase binding IBA --
GO:0019911 structural constituent of myelin sheath IEA --
genes like me logo Genes that share ontologies with MOBP: view

Phenotypes for MOBP Gene

genes like me logo Genes that share phenotypes with MOBP: view

Animal Models for MOBP Gene

MGI Knock Outs for MOBP:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOBP Gene

Localization for MOBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOBP Gene

Cytoplasm, perinuclear region. Note=Present in the major dense line of CNS myelin. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOBP gene
Compartment Confidence
cytoskeleton 3
mitochondrion 3
cytosol 3
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MOBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0030864 cortical actin cytoskeleton IBA --
GO:0043209 myelin sheath IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MOBP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MOBP Gene

Pathways & Interactions for MOBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS,IEA --
GO:0030050 vesicle transport along actin filament IBA --
genes like me logo Genes that share ontologies with MOBP: view

No data available for Pathways by source and SIGNOR curated interactions for MOBP Gene

Drugs & Compounds for MOBP Gene

(1) Drugs for MOBP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MOBP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MOBP: view

Transcripts for MOBP Gene

Unigene Clusters for MOBP Gene

Myelin-associated oligodendrocyte basic protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOBP Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g
SP1: - - - - -
SP2: - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - -
SP8: - - - - - - - - - -
SP9:
SP10: - - - - - - - - - - - - -
SP11: - - - - - -
SP12: - - -
SP13: - - - - - - - - - - -
SP14:

Relevant External Links for MOBP Gene

GeneLoc Exon Structure for
MOBP
ECgene alternative splicing isoforms for
MOBP

Expression for MOBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOBP Gene

mRNA differential expression in normal tissues according to GTEx for MOBP Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x23.2), Brain - Substantia nigra (x7.9), and Brain - Hippocampus (x4.6).

Protein differential expression in normal tissues from HIPED for MOBP Gene

This gene is overexpressed in Brain (50.3), Frontal cortex (11.9), and Spinal cord (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MOBP Gene



Protein tissue co-expression partners for MOBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOBP Gene:

MOBP

SOURCE GeneReport for Unigene cluster for MOBP Gene:

Hs.121333

Evidence on tissue expression from TISSUES for MOBP Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with MOBP: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOBP Gene

Orthologs for MOBP Gene

This gene was present in the common ancestor of mammals.

Orthologs for MOBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOBP 33 34
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia MOBP 33 34
  • 90.62 (n)
cow
(Bos Taurus)
Mammalia MOBP 33 34
  • 86.67 (n)
mouse
(Mus musculus)
Mammalia Mobp 33 16 34
  • 83.83 (n)
rat
(Rattus norvegicus)
Mammalia Mobp 33
  • 81.48 (n)
Species where no ortholog for MOBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MOBP Gene

ENSEMBL:
Gene Tree for MOBP (if available)
TreeFam:
Gene Tree for MOBP (if available)

Paralogs for MOBP Gene

Paralogs for MOBP Gene

(1) SIMAP similar genes for MOBP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MOBP: view

Variants for MOBP Gene

Sequence variations from dbSNP and Humsavar for MOBP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000008865 -- 39,522,550(+) GCCAT(C/T)ATGCT intron-variant
rs1000039002 -- 39,528,224(+) TGTCC(C/T)TACAG nc-transcript-variant
rs1000055228 -- 39,526,534(+) AGCTA(C/T)TCTGT nc-transcript-variant
rs1000173231 -- 39,475,504(+) CTCTA(A/G)TAGTG intron-variant
rs1000182677 -- 39,516,095(+) CAACA(A/G)GGAAC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MOBP Gene

Variant ID Type Subtype PubMed ID
nsv520957 CNV loss 19592680
nsv236980 CNV deletion 16902084
nsv1125397 OTHER inversion 24896259
esv3568706 CNV loss 25503493
esv2759142 CNV gain 17122850
esv2725179 CNV deletion 23290073
esv2425951 CNV deletion 19546169
esv1680226 CNV insertion 17803354
esv1395867 CNV insertion 17803354

Variation tolerance for MOBP Gene

Gene Damage Index Score: 0.28; 6.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOBP Gene

Disorders for MOBP Gene

MalaCards: The human disease database

(4) MalaCards diseases for MOBP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
substance abuse
  • substance-related disorders
corticobasal degeneration
  • cbgd
schizophrenia
  • schizophrenia 12
multiple sclerosis, disease progression, modifier of
  • multiple sclerosis 1
- elite association - COSMIC cancer census association via MalaCards
Search MOBP in MalaCards View complete list of genes associated with diseases

Relevant External Links for MOBP

Genetic Association Database (GAD)
MOBP
Human Genome Epidemiology (HuGE) Navigator
MOBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOBP
genes like me logo Genes that share disorders with MOBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOBP Gene

Publications for MOBP Gene

  1. Cloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin. (PMID: 7989345) Yamamoto Y … Sakoda S (The Journal of biological chemistry 1994) 2 3 4 22 60
  2. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. (PMID: 21685912) Höglinger GU … Schellenberg GD (Nature genetics 2011) 3 45 60
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need AC … Goldstein DB (Human molecular genetics 2009) 3 45 60
  5. Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia. (PMID: 17964117) Mitkus SN … Lipska BK (Schizophrenia research 2008) 3 22 60

Products for MOBP Gene

Sources for MOBP Gene

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