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Aliases for MOB4 Gene

Aliases for MOB4 Gene

  • MOB Family Member 4, Phocein 2 3 5
  • Preimplantation Protein 3 2 3 4
  • Mps One Binder Kinase Activator-Like 3 3 4
  • Class II MMOB1 3 4
  • Mob1 Homolog 3 3 4
  • Phocein 2 2
  • MOBKL3 3 4
  • PREI3 3 4
  • PHOCN 3 4
  • 2C4D 3 4
  • MOB3 3 4
  • MOB1, Mps One Binder Kinase Activator-Like 3 (Yeast) 2
  • MOB1, Mps One Binder Kinase Activator-Like 3 3
  • Phocein, Mob-Like Protein 3
  • Mob-Like Protein 2
  • CGI-95 3
  • MOB1 3

External Ids for MOB4 Gene

Previous HGNC Symbols for MOB4 Gene

  • PREI3
  • MOBKL3

Previous GeneCards Identifiers for MOB4 Gene

  • GC02P198383

Summaries for MOB4 Gene

Entrez Gene Summary for MOB4 Gene

  • This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011]

GeneCards Summary for MOB4 Gene

MOB4 (MOB Family Member 4, Phocein) is a Protein Coding gene. GO annotations related to this gene include kinase binding. An important paralog of this gene is HSPE1-MOB4.

UniProtKB/Swiss-Prot for MOB4 Gene

  • May play a role in membrane trafficking, specifically in membrane budding reactions.

Gene Wiki entry for MOB4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB4 Gene

Genomics for MOB4 Gene

Regulatory Elements for MOB4 Gene

Promoters for MOB4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MOB4 on UCSC Golden Path with GeneCards custom track

Genomic Location for MOB4 Gene

Chromosome:
2
Start:
197,515,571 bp from pter
End:
197,553,699 bp from pter
Size:
38,129 bases
Orientation:
Plus strand

Genomic View for MOB4 Gene

Genes around MOB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB4 Gene

Proteins for MOB4 Gene

  • Protein details for MOB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3A3-PHOCN_HUMAN
    Recommended name:
    MOB-like protein phocein
    Protein Accession:
    Q9Y3A3
    Secondary Accessions:
    • B4DML0
    • Q53SE0
    • Q7Z4Y6
    • Q9H2P3
    • Q9H5J1
    • Q9Y4T8

    Protein attributes for MOB4 Gene

    Size:
    225 amino acids
    Molecular mass:
    26032 Da
    Quaternary structure:
    • Binds STRN4 (By similarity). Interacts with DNM1 and EPS15 (By similarity). Interacts with nucleoside diphosphate kinase (By similarity). Binds STRN and STRN3. Part of a ternary complex containing MOB4/PHOCN, STRN and/or STRN3 and PPA2. Interacts with CTTNBP2 (By similarity). Interacts with CTTNBP2NL.
    SequenceCaution:
    • Sequence=AAP97221.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB45697.1; Type=Frameshift; Positions=168; Evidence={ECO:0000305};

    Alternative splice isoforms for MOB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOB4 Gene

Proteomics data for MOB4 Gene at MOPED

Post-translational modifications for MOB4 Gene

No data available for DME Specific Peptides for MOB4 Gene

Domains & Families for MOB4 Gene

Gene Families for MOB4 Gene

Protein Domains for MOB4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MOB4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3A3

UniProtKB/Swiss-Prot:

PHOCN_HUMAN :
  • Belongs to the MOB1/phocein family.
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB4: view

Function for MOB4 Gene

Molecular function for MOB4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in membrane trafficking, specifically in membrane budding reactions.

Gene Ontology (GO) - Molecular Function for MOB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18782753
GO:0019900 kinase binding IEA --
genes like me logo Genes that share ontologies with MOB4: view
genes like me logo Genes that share phenotypes with MOB4: view

Animal Model Products

miRNA for MOB4 Gene

miRTarBase miRNAs that target MOB4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOB4 Gene

Localization for MOB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOB4 Gene

Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=In a perinuclear punctate pattern. Associated with membranes and the Golgi stacks.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOB4 Gene COMPARTMENTS Subcellular localization image for MOB4 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MOB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
GO:0043025 neuronal cell body IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MOB4: view

Pathways & Interactions for MOB4 Gene

SuperPathways for MOB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOB4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MOB4 Gene

Drugs & Compounds for MOB4 Gene

No Compound Related Data Available

Transcripts for MOB4 Gene

Unigene Clusters for MOB4 Gene

MOB family member 4, phocein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOB4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1:
SP2: -
SP3: - - -

Relevant External Links for MOB4 Gene

GeneLoc Exon Structure for
MOB4
ECgene alternative splicing isoforms for
MOB4

Expression for MOB4 Gene

mRNA expression in normal human tissues for MOB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOB4 Gene

This gene is overexpressed in Adrenal Gland (x9.2).

Protein differential expression in normal tissues from HIPED for MOB4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MOB4 Gene



SOURCE GeneReport for Unigene cluster for MOB4 Gene Hs.633165

genes like me logo Genes that share expression patterns with MOB4: view

Protein tissue co-expression partners for MOB4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MOB4 Gene

Orthologs for MOB4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOBKL3 35
  • 100 (n)
  • 100 (a)
MOBKL3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MOBKL3 36
  • 100 (a)
OneToMany
MOBKL3 35
  • 96.44 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia MOB4 35
  • 96.15 (n)
  • 100 (a)
-- 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mob4 16
Mob4 36
  • 100 (a)
OneToOne
Mob4 35
  • 95.56 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 100 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mob4 35
  • 95.41 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves MOB4 35
  • 89.89 (n)
  • 99.55 (a)
MOB4 36
  • 99 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 99 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mob4 35
  • 87.41 (n)
  • 96.89 (a)
Str.6283 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4156 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11998 35
mob4 35
  • 77.78 (n)
  • 93.78 (a)
mob4 36
  • 93 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007306 35
  • 68.32 (n)
  • 81.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mob4 36
  • 79 (a)
OneToMany
Mob4 35
  • 66.07 (n)
  • 80.72 (a)
worm
(Caenorhabditis elegans)
Secernentea C30A5.3 36
  • 67 (a)
OneToMany
C30A5.3 35
  • 63.43 (n)
  • 69.44 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07674 35
  • 44.34 (n)
  • 36.84 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4050 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5204 36
  • 72 (a)
OneToMany
Species with no ortholog for MOB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOB4 Gene

ENSEMBL:
Gene Tree for MOB4 (if available)
TreeFam:
Gene Tree for MOB4 (if available)

Paralogs for MOB4 Gene

Paralogs for MOB4 Gene

(1) SIMAP similar genes for MOB4 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MOB4 Gene

genes like me logo Genes that share paralogs with MOB4: view

Variants for MOB4 Gene

Variation tolerance for MOB4 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOB4 Gene

HapMap Linkage Disequilibrium report
MOB4
Human Gene Mutation Database (HGMD)
MOB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MOB4 Gene

Disorders for MOB4 Gene

Relevant External Links for MOB4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOB4

No disorders were found for MOB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOB4 Gene

Publications for MOB4 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Phocein: A potential actor in vesicular trafficking at Purkinje cell dendritic spines. (PMID: 17853115) Bailly Y.J. … Castets F. (Cerebellum 2007) 2 3
  3. A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes. (PMID: 11319234) Moreno C.S. … Pallas D.C. (J. Biol. Chem. 2001) 2 3
  4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MOB4 Gene

Sources for MOB4 Gene

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