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Aliases for MOB4 Gene

Aliases for MOB4 Gene

  • MOB Family Member 4, Phocein 2 3 5
  • Preimplantation Protein 3 2 3 4
  • Mps One Binder Kinase Activator-Like 3 3 4
  • Phocein, Mob-Like Protein 2 3
  • Class II MMOB1 3 4
  • Mob1 Homolog 3 3 4
  • MOBKL3 3 4
  • PREI3 3 4
  • PHOCN 3 4
  • 2C4D 3 4
  • MOB3 3 4
  • MOB1, Mps One Binder Kinase Activator-Like 3 (Yeast) 2
  • MOB1, Mps One Binder Kinase Activator-Like 3 3
  • MOB-Like Protein Phocein 3
  • Phocein 2
  • CGI-95 3
  • MOB1 3

External Ids for MOB4 Gene

Previous HGNC Symbols for MOB4 Gene

  • PREI3
  • MOBKL3

Previous GeneCards Identifiers for MOB4 Gene

  • GC02P198383

Summaries for MOB4 Gene

Entrez Gene Summary for MOB4 Gene

  • This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011]

GeneCards Summary for MOB4 Gene

MOB4 (MOB Family Member 4, Phocein) is a Protein Coding gene. Diseases associated with MOB4 include Myeloproliferative Syndrome, Transient and Cerebral Cavernous Malformations 3. GO annotations related to this gene include kinase binding. An important paralog of this gene is HSPE1-MOB4.

UniProtKB/Swiss-Prot for MOB4 Gene

  • May play a role in membrane trafficking, specifically in membrane budding reactions.

Gene Wiki entry for MOB4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB4 Gene

Genomics for MOB4 Gene

Regulatory Elements for MOB4 Gene

Enhancers for MOB4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G197203 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.9 -304.3 -304286 15.7 HDGF PKNOX1 FOXA2 WRNIP1 YY1 TCF12 GATA2 FOS JUNB TBX21 ANKRD44 ANKRD44-IT1 LOC105373824 MOB4 COQ10B SF3B1 MARS2 HSPD1 LOC105373826 LOC101927596
GH02G197194 1.4 Ensembl ENCODE dbSUPER 6.6 -317.3 -317292 8.4 HDGF TBP TBL1XR1 WRNIP1 SIN3A ZBTB40 TCF12 GATA2 EGR1 CBX5 ANKRD44-IT1 LOC105373824 ANKRD44 SF3B1 RNU6-1029P ENSG00000202434 MOB4 CCDC150 LOC101927596 LOC105373826
GH02G197292 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.3 -219.9 -219921 6.7 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 BMI1 ZBTB7B CBX5 ZNF207 RELB ANKRD44 LOC101927596 COQ10B SF3B1 MOB4 ANKRD44-IT1 GC02P197264
GH02G197180 0.6 dbSUPER 5.2 -332.9 -332855 3.7 FOSL1 FOS HNF4A ZNF24 MAFK ZBTB40 ANKRD44-IT1 LOC105373824 ANKRD44 ENSG00000202434 SF3B1 MOB4 LOC101927596 GC02P197128
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MOB4 on UCSC Golden Path with GeneCards custom track

Promoters for MOB4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MOB4 Gene

197,515,571 bp from pter
197,553,699 bp from pter
38,129 bases
Plus strand

Genomic View for MOB4 Gene

Genes around MOB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB4 Gene

Proteins for MOB4 Gene

  • Protein details for MOB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MOB-like protein phocein
    Protein Accession:
    Secondary Accessions:
    • B4DML0
    • Q53SE0
    • Q7Z4Y6
    • Q9H2P3
    • Q9H5J1
    • Q9Y4T8

    Protein attributes for MOB4 Gene

    225 amino acids
    Molecular mass:
    26032 Da
    Quaternary structure:
    • Binds STRN4 (By similarity). Interacts with DNM1 and EPS15 (By similarity). Interacts with nucleoside diphosphate kinase (By similarity). Binds STRN and STRN3. Part of a ternary complex containing MOB4/PHOCN, STRN and/or STRN3 and PPA2. Interacts with CTTNBP2 (By similarity). Interacts with CTTNBP2NL.
    • Sequence=AAP97221.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB45697.1; Type=Frameshift; Positions=168; Evidence={ECO:0000305};

    Alternative splice isoforms for MOB4 Gene


neXtProt entry for MOB4 Gene

Post-translational modifications for MOB4 Gene

No data available for DME Specific Peptides for MOB4 Gene

Domains & Families for MOB4 Gene

Gene Families for MOB4 Gene

Protein Domains for MOB4 Gene


Suggested Antigen Peptide Sequences for MOB4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MOB1/phocein family.
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB4: view

Function for MOB4 Gene

Molecular function for MOB4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in membrane trafficking, specifically in membrane budding reactions.

Gene Ontology (GO) - Molecular Function for MOB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18782753
GO:0019900 kinase binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB4: view
genes like me logo Genes that share phenotypes with MOB4: view

Animal Model Products

miRNA for MOB4 Gene

miRTarBase miRNAs that target MOB4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MOB4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOB4 Gene

Localization for MOB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOB4 Gene

Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Note=In a perinuclear punctate pattern. Associated with membranes and the Golgi stacks.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOB4 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MOB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005794 Golgi apparatus IDA,IEA 11251078
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with MOB4: view

Pathways & Interactions for MOB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with MOB4: view

No data available for Pathways by source and SIGNOR curated interactions for MOB4 Gene

Drugs & Compounds for MOB4 Gene

No Compound Related Data Available

Transcripts for MOB4 Gene

Unigene Clusters for MOB4 Gene

MOB family member 4, phocein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MOB4

Alternative Splicing Database (ASD) splice patterns (SP) for MOB4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP2: -
SP3: - - -

Relevant External Links for MOB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MOB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOB4 Gene

This gene is overexpressed in Adrenal Gland (x9.2).

Protein differential expression in normal tissues from HIPED for MOB4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MOB4 Gene

Protein tissue co-expression partners for MOB4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOB4 Gene:


SOURCE GeneReport for Unigene cluster for MOB4 Gene:


Evidence on tissue expression from TISSUES for MOB4 Gene

  • Nervous system(4.9)
  • Adrenal gland(4.3)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with MOB4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOB4 Gene

Orthologs for MOB4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MOBKL3 34 35
  • 100 (n)
(Canis familiaris)
Mammalia -- 35
  • 100 (a)
MOB4 34
  • 96.15 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 100 (a)
(Bos Taurus)
Mammalia MOBKL3 34 35
  • 96.44 (n)
(Mus musculus)
Mammalia Mob4 34 16 35
  • 95.56 (n)
(Rattus norvegicus)
Mammalia Mob4 34
  • 95.41 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
(Gallus gallus)
Aves MOB4 34 35
  • 89.89 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mob4 34
  • 87.41 (n)
Str.6283 34
(Danio rerio)
Actinopterygii mob4 34 35
  • 77.78 (n)
Dr.11998 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4156 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007306 34
  • 68.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mob4 34 35
  • 66.07 (n)
(Caenorhabditis elegans)
Secernentea C30A5.3 34 35
  • 63.43 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5204 35
  • 72 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07674 34
  • 44.34 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4050 34
Species where no ortholog for MOB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOB4 Gene

Gene Tree for MOB4 (if available)
Gene Tree for MOB4 (if available)

Paralogs for MOB4 Gene

Paralogs for MOB4 Gene

(1) SIMAP similar genes for MOB4 Gene using alignment to 4 proteins: Pseudogenes for MOB4 Gene

genes like me logo Genes that share paralogs with MOB4: view

Variants for MOB4 Gene

Sequence variations from dbSNP and Humsavar for MOB4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000030238 -- 197,521,807(+) AACAA(A/T)TGCTG intron-variant
rs1000084624 -- 197,532,820(+) GAAGA(C/T)TGGGT intron-variant
rs1000153737 -- 197,536,496(+) GCCTG(G/T)GTTTT intron-variant
rs1000250120 -- 197,516,361(+) GTAGG(A/C)GTGAG intron-variant
rs1000308524 -- 197,542,764(+) CTGCT(A/G)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOB4 Gene

Variant ID Type Subtype PubMed ID
esv3443077 CNV insertion 20981092
nsv1014881 CNV gain 25217958
nsv584156 CNV gain 21841781
nsv963758 CNV duplication 23825009
nsv979162 CNV duplication 23825009

Variation tolerance for MOB4 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOB4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOB4 Gene

Disorders for MOB4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MOB4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
myeloproliferative syndrome, transient
  • transient myeloproliferative syndrome
cerebral cavernous malformations 3
  • cerebral cavernous malformation 3
central nervous system hemangioma
  • hemangioma of cns
- elite association - COSMIC cancer census association via MalaCards
Search MOB4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MOB4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MOB4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOB4 Gene

Publications for MOB4 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes. (PMID: 11319234) Moreno C.S. … Pallas D.C. (J. Biol. Chem. 2001) 2 3 4 64
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  4. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M. … Gingras A.C. (Mol. Cell. Proteomics 2009) 3 4 64
  5. Phocein: A potential actor in vesicular trafficking at Purkinje cell dendritic spines. (PMID: 17853115) Bailly Y.J. … Castets F. (Cerebellum 2007) 2 3 64

Products for MOB4 Gene

  • Addgene plasmids for MOB4

Sources for MOB4 Gene

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