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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MOB4 Gene

protein-coding   GIFtS: 47
GCID: GC02P198383

MOB family member 4, phocein

(Previous names: preimplantation protein 3, MOB1, Mps One Binder kinase...)
(Previous symbols: PREI3, MOBKL3)
 Explore 4 diseases affiliated with
MOB4 via our new
 Human Malady Compendium 
Biological research products
for MOB4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
MOB Family Member 4, Phocein1 2     Mps One Binder Kinase Activator-Like 32 3
MOB31 2 3 5     MOB12 5
MOBKL31 2 3 5     CGI-951
PREI31 2 3 5     DKFZP564M1121
Preimplantation Protein 31 2 3     MOB1, Mps One Binder Kinase Activator-Like 3 (Yeast)1
2C4D1 2 3     MOB-Like Protein Phocein2
PHOCN1 2 3     MOB1, Mps One Binder Kinase Activator-Like 32
Class II MMOB12 3     Phocein, Mob-Like Protein2
Mob1 Homolog 32 3     Mob33

External Ids:    HGNC: 172611   Entrez Gene: 258432   Ensembl: ENSG000001155407   OMIM: 6093615   UniProtKB: Q9Y3A33   

Export aliases for MOB4 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MOB4:
This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest
that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene
activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally
occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.(provided by RefSeq,
Feb 2011)

UniProtKB/Swiss-Prot: PHOCN_HUMAN, Q9Y3A3
Function: May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity)

Gene Wiki entry for MOB4 (MOBKL3)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MOB4
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MOB4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MOB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

MOB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOB4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P198383:  view genomic region     (about GC identifiers)

Start:
198,380,295 bp from pter      End:
198,418,423 bp from pter
Size:
38,129 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PHOCN_HUMAN, Q9Y3A3 (See protein sequence)
Recommended Name: MOB-like protein phocein  
Size: 225 amino acids; 26032 Da
Subunit: Binds STRN4 (By similarity). Interacts with DNM1 and EPS15 (By similarity). Interacts with nucleoside
diphosphate kinase (By similarity). Binds STRN and STRN3. Part of a ternary complex containing MOB4/PHOCN, STRN and/or
STRN3 and PPA2
Subcellular location: Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Golgi apparatus, Golgi
stack membrane; Peripheral membrane protein. Note=In a perinuclear punctate pattern. Associated with membranes and the
Golgi stacks
Sequence caution: Sequence=AAP97221.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAB45697.1; Type=Frameshift; Positions=168;
Secondary accessions: B4DML0 Q53SE0 Q7Z4Y6 Q9H2P3 Q9H5J1 Q9Y4T8
Alternative splicing: 3 isoforms:  Q9Y3A3-1   Q9Y3A3-2   Q9Y3A3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MOB4: NX_Q9Y3A3

Post-translational modifications:

  • Phosphorylated on serine residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y3A3

  • MOB4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001094289.1  NP_001191023.1  NP_056202.2  NP_955776.1  

    ENSEMBL proteins: 
     ENSP00000233892   ENSP00000387240   ENSP00000315702   ENSP00000405354   ENSP00000397052  
     ENSP00000387043   ENSP00000387289  

    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MOB4

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm ISS--
    GO:0005794Golgi apparatus IDA11251078
    GO:0032580Golgi cisterna membrane IEA--
    GO:0048471perinuclear region of cytoplasm IEA--


    MOB4 for ontologies           About GeneDecksing



    MOB4 Antibody Products: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MOB4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005301 Mob1_phocein

    Graphical View of Domain Structure for InterPro Entry Q9Y3A3

    ProtoNet protein and cluster: Q9Y3A3

    1 Blocks protein family: IPB005301 Mob1/phocein family

    UniProtKB/Swiss-Prot: PHOCN_HUMAN, Q9Y3A3
    Similarity: Belongs to the MOB1/phocein family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PHOCN_HUMAN, Q9Y3A3
    Function: May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity)

    miRNA
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    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19156129
    GO:0019900kinase binding IEA--
    GO:0046872metal ion binding IEA--


    MOB4 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MOB4:
     Cell cycle / mitosis defect  Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/87 Interacting proteins for MOB4 (Q9Y3A31, 2, 3 ENSP000003157024) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-68254 I2D: score=5 STRING: ENSP00000311695
    MED31Q9Y3C72, 3, ENSP000002257284MINT-65842 I2D: score=5 STRING: ENSP00000225728
    PAICSP222342, 3, ENSP000003825954MINT-65824 I2D: score=5 STRING: ENSP00000382595
    EGLN2Q96KS02, 3MINT-65838 I2D: score=4 
    MYL6P606602, 3, ENSP000002934224MINT-65826 I2D: score=4 STRING: ENSP00000293422
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--


    MOB4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MOB4
    Search CenterWatch for drugs/clinical trials and news about MOB4 / PHOCN 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MOB4 gene (4 alternative transcripts): 
    NM_001100819.2  NM_001204094.1  NM_015387.4  NM_199482.3  

    Unigene Cluster for MOB4:

    MOB family member 4, phocein
    Hs.633165  [show with all ESTs]
    Unigene Representative Sequence: NM_001202485
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233892(uc021vum.1 uc002uum.4 uc021vun.1) ENST00000409916
    ENST00000323303(uc002uun.4 uc010fsn.3 uc010fso.3 uc010zgz.2)
    ENST00000448447 ENST00000497443 ENST00000417097 ENST00000409355 ENST00000409360


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    Inhib. RNA
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    Additional cDNA sequence: 

    AB015441.1 AF093825.1 AF151853.1 AF250319.1 AJ580638.1 AK027043.1 AK289377.1 AK292938.1 
    AK297294.1 AK297514.1 AK307497.1 AL080070.1 BC005237.1 CR457371.1 

    16 DOTS entries:

    DT.97814137  DT.100819573  DT.101981122  DT.416531  DT.91754412  DT.121018735  DT.100741860  DT.100642204 
    DT.91754411  DT.91754410  DT.121018643  DT.121001085  DT.100044970  DT.100819575  DT.40110500  DT.100819574 

    24/780 AceView cDNA sequences (see all 780):

    AI016008 AA313990 AA459269 AW005438 AA962519 BE908962 AI184152 AL527606 
    AI042038 BM474351 BM559301 AI564285 AI052005 Z43461 AI091691 AW090017 
    BG180939 BM661622 BU192128 BE272055 AA004221 AA460995 AW006187 AI925138 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MOB4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
    SP1:                                                                        
    SP2:                    -                                                   
    SP3:                    -     -                 -                           


    ECgene alternative splicing isoforms for MOB4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MOB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MOB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MOB4

    SOURCE GeneReport for Unigene cluster: Hs.633165
        SABiosciences Custom PCR Arrays for MOB4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MOB4 gene from 7/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mob41 , 5 MOB family member 4, phocein1, 5 95.56(n)1
    100(a)1
      1 (28.03 cM)5
    190701  NM_025283.31  NP_079559.21 
     551312315 
    chicken
    (Gallus gallus)
    Aves MOB41 MOB family member 4, phocein 89.89(n)
    99.55(a)
      429007  NM_001031557.1  NP_001026728.1 
    lizard
    (Anolis carolinensis)
    Reptilia MOB46
    --
    99(a)
    1 ↔ 1
    GL343436.1(652403-663588)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA972145.12   -- 81.56(n)    CA972145.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.119982 Transcribed sequence with strong similarity to protein more 79.02(n)    CK397421.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mob41 CG3403-PA 66.07(n)
    80.72(a)
      35576  NM_136385.3  NP_610229.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C30A5.31 Protein C30A5.3 63.43(n)
    69.44(a)
      176158  NM_066397.3  NP_498798.2 


    ENSEMBL Gene Tree for MOB4 (if available)
    TreeFam Gene Tree for MOB4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MOB4 gene

    MOB4 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for MOB4
    PGOHUM00000242394 PGOHUM00000242468 PGOHUM00000240088


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/624 NCBI SNPs in MOB4 are shown (see all 624    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1147717891,2
    C,F,--198378323(+) TATTGC/TCTTTA 2 -- int1 us2k11Minor allele frequency- T:0.02WA 118
    rs571292171,2
    C,F,--198378388(+) GTTATT/CGTTGA 2 -- int1 us2k13Minor allele frequency- C:0.20WA CSA 122
    rs75906971,2
    C,F,H,--198378546(+) TAAAGA/GACAAG 2 -- int1 us2k118Minor allele frequency- G:0.15NS EA NA WA 2346
    rs1826485371,2
    --198378600(+) TTTATC/TGGACT 2 -- int1 us2k10--------
    rs1446971871,2
    --198378619(+) ACAACA/GAATGT 2 -- us2k1 int10--------
    rs1385119011,2
    --198378637(+) GTTCCC/TGAATT 2 -- int1 us2k10--------
    rs1164423951,2
    --198378644(+) AATTTA/GACACC 2 -- int1 us2k11Minor allele frequency- G:0.01WA 118
    rs1402407371,2
    --198378661(+) TTCACA/GTTTTT 2 -- us2k1 int10--------
    rs750216001,2
    --198378854(+) GACTCT/CGCTAT 4 -- int1 us2k12Minor allele frequency- C:0.09CSA WA 120
    rs1504711451,2
    --198379052(+) GTGACC/TGGTTG 5 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for MOB4 (198380295 - 198418423 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MOB4: --
    Human Gene Mutation Database (HGMD): MOB4

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MOB4 for disorders           About GeneDecksing

    OMIM gene information: 609361    OMIM disorders: --

    4 diseases for MOB4:    About MalaCards
    cerebral cavernous malformations    cavernous malformation    cerebral cavernous malformations 3    cerebritis


    Export disorders for MOB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MOB4 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with MOB4)
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    1. A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes. (PubMed id 11319234)1, 2, 3 Moreno C.S....Pallas D.C. (2001)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    4. Phocein: A potential actor in vesicular trafficking a t Purkinje cell dendritic spines. (PubMed id 17853115)1, 3 Bailly Y.J. and Castets F. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25843 HGNC: 17261 AceView: HSPE1andPREI3 Ensembl:ENSG00000115540 euGenes: HUgn25843
    ECgene: MOB4 H-InvDB: MOB4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MOB4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MOB4 gene:
    Search GeneIP for patents involving MOB4

    GeneCards and IP:
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