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MOB4 Gene

protein-coding   GIFtS: 47
GCID: GC02P198383

MOB Family Member 4, Phocein

(Previous names: preimplantation protein 3, MOB1, Mps One Binder kinase activator-like...)
(Previous symbols: PREI3, MOBKL3)
  See MOB4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MOB Family Member 4, Phocein1 2     PHOCN2 3
MOBKL31 2 3 5     MOB12 5
PREI31 2 3 5     Mob-Like Protein1
Preimplantation Protein 31 2 3     MOB1, Mps One Binder Kinase Activator-Like 3 (Yeast)1
MOB32 3 5     phocein1
Class II MMOB12 3     MOB-Like Protein Phocein2
Mob1 Homolog 32 3     MOB1, Mps One Binder Kinase Activator-Like 32
Mps One Binder Kinase Activator-Like 32 3     Phocein, Mob-Like Protein2
2C4D2 3     Mob33

External Ids:    HGNC: 172611   Entrez Gene: 258432   Ensembl: ENSG000001155407   OMIM: 6093615   UniProtKB: Q9Y3A33   

Export aliases for MOB4 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MOB4 Gene:
This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart
suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following
zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Naturally occurring read-through transcription occurs between this locus and the neighboring locus
HSPE1.(provided by RefSeq, Feb 2011)

GeneCards Summary for MOB4 Gene:
MOB4 (MOB family member 4, phocein) is a protein-coding gene. Diseases associated with MOB4 include cavernous malformation, and cerebral cavernous malformation. GO annotations related to this gene include kinase binding. An important paralog of this gene is HSPE1-MOB4.

UniProtKB/Swiss-Prot: PHOCN_HUMAN, Q9Y3A3
Function: May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity)

Gene Wiki entry for MOB4 (MOBKL3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MOB4
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MOB4 promoter sequence
   Search Chromatin IP Primers for MOB4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MOB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

MOB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOB4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P198383:  view genomic region     (about GC identifiers)

Start:
198,380,295 bp from pter      End:
198,418,423 bp from pter
Size:
38,129 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PHOCN_HUMAN, Q9Y3A3 (See protein sequence)
Recommended Name: MOB-like protein phocein  
Size: 225 amino acids; 26032 Da
Subunit: Binds STRN4 (By similarity). Interacts with DNM1 and EPS15 (By similarity). Interacts with nucleoside
diphosphate kinase (By similarity). Binds STRN and STRN3. Part of a ternary complex containing MOB4/PHOCN, STRN
and/or STRN3 and PPA2. Interacts with CTTNBP2 (By similarity). Interacts with CTTNBP2NL
Sequence caution: Sequence=AAP97221.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAB45697.1; Type=Frameshift; Positions=168;
Secondary accessions: B4DML0 Q53SE0 Q7Z4Y6 Q9H2P3 Q9H5J1 Q9Y4T8
Alternative splicing: 3 isoforms:  Q9Y3A3-1   Q9Y3A3-2   Q9Y3A3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MOB4: NX_Q9Y3A3

Explore proteomics data for MOB4 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MOB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001094289.1  NP_001191023.1  NP_056202.2  NP_955776.1  

    ENSEMBL proteins: 
     ENSP00000233892   ENSP00000387240   ENSP00000315702   ENSP00000405354   ENSP00000397052  
     ENSP00000387043   ENSP00000387289  

    MOB4 Human Recombinant Protein Products:

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    antibodies-online peptides for MOB4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MOB: MOB kinase activators

    1 InterPro protein domain:
     IPR005301 Mob1_phocein

    Graphical View of Domain Structure for InterPro Entry Q9Y3A3

    ProtoNet protein and cluster: Q9Y3A3

    1 Blocks protein domain: IPB005301 Mob1/phocein family

    UniProtKB/Swiss-Prot: PHOCN_HUMAN, Q9Y3A3
    Similarity: Belongs to the MOB1/phocein family


    Find genes that share domains with MOB4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHOCN_HUMAN, Q9Y3A3
    Function: May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18782753
    GO:0019900kinase binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with MOB4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MOB4:
     Cell cycle / mitosis defect  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MOB4
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    miRNA
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    hsa-mir-18a-5p (MIRT031318), hsa-mir-101-3p (MIRT027305), hsa-mir-1 (MIRT023746)

    Block miRNA regulation of human, mouse, rat MOB4 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PHOCN_HUMAN, Q9Y3A3: Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Golgi apparatus, Golgi
    stack membrane; Peripheral membrane protein. Note=In a perinuclear punctate pattern. Associated with membranes
    and the Golgi stacks

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005794Golgi apparatus IDA11251078
    GO:0016020membrane ----
    GO:0032580Golgi cisterna membrane IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with MOB4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MOB4
    Interactions:

        Search GeneGlobe Interaction Network for MOB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MOB4 (Q9Y3A31, 2, 3 ENSP000003157024) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-68254 I2D: score=5 STRING: ENSP00000311695
    PAICSP222342, 3, ENSP000003825954MINT-65824 I2D: score=5 STRING: ENSP00000382595
    MYL6P606602, 3, ENSP000002934224MINT-65826 I2D: score=4 STRING: ENSP00000293422
    MYO9BQ134592, 3, ENSP000003804444MINT-65828 I2D: score=4 STRING: ENSP00000380444
    CTTNBP2NLQ9P2B41, 3, ENSP000002712774EBI-713935,EBI-1774273 I2D: score=2 STRING: ENSP00000271277
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    Find genes that share ontologies with MOB4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MOB4 (PHOCN)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MOB4 gene (4 alternative transcripts): 
    NM_001100819.2  NM_001204094.1  NM_015387.4  NM_199482.3  

    Unigene Cluster for MOB4:

    MOB family member 4, phocein
    Hs.633165  [show with all ESTs]
    Unigene Representative Sequence: NM_001202485
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233892(uc021vum.1 uc002uum.4 uc021vun.1) ENST00000409916
    ENST00000323303(uc002uun.4 uc010fsn.3 uc010fso.3 uc010zgz.2)
    ENST00000448447 ENST00000497443 ENST00000417097 ENST00000409355 ENST00000409360

    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MOB4
      QuantiFast Probe-based Assays in human, mouse, rat MOB4

    Additional mRNA sequence: 

    AB015441.1 AF093825.1 AF151853.1 AF250319.1 AJ580638.1 AK027043.1 AK289377.1 AK292938.1 
    AK297294.1 AK297514.1 AK307497.1 AL080070.1 BC005237.1 CR457371.1 

    23 DOTS entries:

    DT.97814137  DT.101981122  DT.100819573  DT.91754412  DT.416531  DT.100642204  DT.121018735  DT.100741860 
    DT.91754411  DT.91754410  DT.121018643  DT.121001085  DT.100044970  DT.100044974  DT.100819574  DT.100819575 
    DT.121018744  DT.40110500  DT.86845022  DT.100884127  DT.101986431  DT.121018720  DT.92461973 

    Selected AceView cDNA sequences (see all 780):

    BQ574072 CR602742 AI057092 AW139626 AA315008 AA568481 BM791739 AI652875 
    CK570310 BM452401 AB015441 AI051268 AI925138 X75821 BM709768 NM_002157 
    BI869469 AI867022 AW875837 N91932 BQ013337 AA459269 BF939518 AL527606 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MOB4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
    SP1:                                                                        
    SP2:                    -                                                   
    SP3:                    -     -                 -                           


    ECgene alternative splicing isoforms for MOB4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MOB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MOB4 Expression
    About this image


    MOB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Adrenal Gland (Endocrine System)
    MOB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MOB4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.633165
        Custom PCR Arrays for MOB4
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MOB4 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mob41 , 5 MOB family member 4, phocein1, 5 95.56(n)1
    100(a)1
      1 (28.03 cM)5
    190701  NM_025283.31  NP_079559.21 
     551312315 
    chicken
    (Gallus gallus)
    Aves MOB41 MOB family member 4, phocein 89.89(n)
    99.55(a)
      429007  NM_001031557.1  NP_001026728.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    99(a)
    1 → many
    GL343436.1(652403-663588)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA972145.12   -- 81.56(n)    CA972145.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.119982 Transcribed sequence with strong similarity to protein more 79.02(n)    CK397421.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mob41 Mob4 66.07(n)
    80.72(a)
      35576  NM_001259222.2  NP_001246151.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C30A5.31 C30A5.3 63.43(n)
    69.44(a)
      176158  NM_066397.4  NP_498798.2 


    ENSEMBL Gene Tree for MOB4 (if available)
    TreeFam Gene Tree for MOB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MOB4 gene
    HSPE1-MOB42  
    1 SIMAP similar gene for MOB4 using alignment to 4 protein entries:     PHOCN_HUMAN (see all proteins):
    HSPE1-MOB4

    Find genes that share paralogs with MOB4           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for MOB4
    PGOHUM00000242394 PGOHUM00000242468 PGOHUM00000240088


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Human Gene Mutation Database (HGMD): MOB4
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MOB4
    DNA2.0 Custom Variant and Variant Library Synthesis for MOB4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609361    OMIM disorders: --

    2 diseases for MOB4:    
    About MalaCards
    cavernous malformation    cerebral cavernous malformation


    Find genes that share disorders with MOB4           About GenesLikeMe


    Export disorders for MOB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MOB4 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with MOB4)
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    1. A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes. (PubMed id 11319234)1, 2, 3 Moreno C.S.... Pallas D.C. (J. Biol. Chem. 2001)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    4. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PubMed id 18782753)1, 2 Goudreault M.... Gingras A.C. (Mol. Cell. Proteomics 2009)
    5. Phocein: A potential actor in vesicular trafficking at Purkinje cell dendritic spines. (PubMed id 17853115)1, 3 Bailly Y.J. and Castets F. (Cerebellum 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25843 HGNC: 17261 AceView: HSPE1andPREI3 Ensembl:ENSG00000115540 euGenes: HUgn25843
    ECgene: MOB4 H-InvDB: MOB4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MOB4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MOB4 gene:
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    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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