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Aliases for MOB3C Gene

Aliases for MOB3C Gene

  • MOB Kinase Activator 3C 2 3 5
  • Mob1 Homolog 2C 3 4
  • MOBKL2C 3 4
  • MOB1, Mps One Binder Kinase Activator-Like 2C (Yeast) 2
  • MOB1, Mps One Binder Kinase Activator-Like 2C 3
  • Mps One Binder Kinase Activator-Like 2C 4
  • MOB1E 3

External Ids for MOB3C Gene

Previous HGNC Symbols for MOB3C Gene

  • MOBKL2C

Previous GeneCards Identifiers for MOB3C Gene

  • GC01M046443
  • GC01M047075

Summaries for MOB3C Gene

Entrez Gene Summary for MOB3C Gene

  • The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for MOB3C Gene

MOB3C (MOB Kinase Activator 3C) is a Protein Coding gene. An important paralog of this gene is MOB3A.

UniProtKB/Swiss-Prot for MOB3C Gene

  • May regulate the activity of kinases.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB3C Gene

Genomics for MOB3C Gene

Regulatory Elements for MOB3C Gene

Enhancers for MOB3C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F046610 1 ENCODE 11.2 +2.6 2577 7.0 ATF1 PKNOX1 CREB3L1 ZNF133 SIN3A GLIS2 ELK1 ZNF143 FOS SP3 MKNK1 MOB3C GC01P046604
GH01F046594 0.9 Ensembl ENCODE 11.9 +21.8 21785 2.2 SMARCA5 SCRT1 PKNOX1 ATF1 MAX ZBTB40 JUND ZNF318 SCRT2 IKZF1 MKNK1 MOB3C EFCAB14 TEX38 ATPAF1 EFCAB14-AS1 GC01P046604 KNCN
GH01F046675 0.8 ENCODE 10 -59.6 -59585 2.3 SOX13 IRF2 ETV1 TEAD4 ZNF175 CEBPG TEAD1 HLF NR2F1 NR4A1 EFCAB14 MKNK1 MOB3C EFCAB14-AS1 LOC105378698
GH01F046653 0.6 ENCODE 11.3 -36.7 -36705 0.7 OSR2 GATA3 ZBTB48 ZNF580 FEZF1 MNT PRDM1 TCF7L2 EFCAB14 MKNK1 MOB3C NENFP1 LOC105378697
GH01F046516 1.1 Ensembl ENCODE 5 +99.3 99312 2.1 TBP HDGF HDAC1 KLF17 GLIS2 GATA2 SMARCC2 EGR2 SMARCC1 SP3 KNCN MOB3C MKNK1 GC01P046525 DMBX1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MOB3C on UCSC Golden Path with GeneCards custom track

Promoters for MOB3C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000165156 191 1401 ATF1 CREB3L1 SIN3A ELK1 ZNF143 SP3 GLIS1 NBN KDM1A ASH2L

Genomic Location for MOB3C Gene

Chromosome:
1
Start:
46,607,715 bp from pter
End:
46,616,891 bp from pter
Size:
9,177 bases
Orientation:
Minus strand

Genomic View for MOB3C Gene

Genes around MOB3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB3C Gene

Proteins for MOB3C Gene

  • Protein details for MOB3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70IA8-MOB3C_HUMAN
    Recommended name:
    MOB kinase activator 3C
    Protein Accession:
    Q70IA8
    Secondary Accessions:
    • D3DQ22
    • Q0VA98
    • Q5TC10
    • Q5TC11
    • Q8NAZ2
    • Q8NF28

    Protein attributes for MOB3C Gene

    Size:
    216 amino acids
    Molecular mass:
    25623 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC03752.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI14766.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for MOB3C Gene

Post-translational modifications for MOB3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MOB3C Gene

No data available for DME Specific Peptides for MOB3C Gene

Domains & Families for MOB3C Gene

Gene Families for MOB3C Gene

Protein Domains for MOB3C Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MOB3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q70IA8

UniProtKB/Swiss-Prot:

MOB3C_HUMAN :
  • Belongs to the MOB1/phocein family.
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB3C: view

Function for MOB3C Gene

Molecular function for MOB3C Gene

UniProtKB/Swiss-Prot Function:
May regulate the activity of kinases.

Gene Ontology (GO) - Molecular Function for MOB3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB3C: view
genes like me logo Genes that share phenotypes with MOB3C: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOB3C Gene

Localization for MOB3C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOB3C gene
Compartment Confidence
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MOB3C Gene

Pathways & Interactions for MOB3C Gene

SuperPathways for MOB3C Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOB3C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MOB3C Gene

Transcripts for MOB3C Gene

Unigene Clusters for MOB3C Gene

MOB kinase activator 3C:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOB3C Gene

No ASD Table

Relevant External Links for MOB3C Gene

GeneLoc Exon Structure for
MOB3C
ECgene alternative splicing isoforms for
MOB3C

Expression for MOB3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MOB3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MOB3C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.6), Liver, secretome (23.3), and Platelet (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MOB3C Gene



Protein tissue co-expression partners for MOB3C Gene

NURSA nuclear receptor signaling pathways regulating expression of MOB3C Gene:

MOB3C

SOURCE GeneReport for Unigene cluster for MOB3C Gene:

Hs.632401
genes like me logo Genes that share expression patterns with MOB3C: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MOB3C Gene

Orthologs for MOB3C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOB3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOB3C 35
  • 100 (a)
OneToOne
MOBKL2C 34
  • 99.69 (n)
cow
(Bos Taurus)
Mammalia MOB3C 34 35
  • 92.13 (n)
mouse
(Mus musculus)
Mammalia Mob3c 34 16 35
  • 90.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MOB3C 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOB3C 34 35
  • 89.63 (n)
rat
(Rattus norvegicus)
Mammalia Mob3c 34
  • 89.37 (n)
oppossum
(Monodelphis domestica)
Mammalia MOB3C 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOB3C 35
  • 84 (a)
OneToOne
MOBKL2C 34
  • 80.86 (n)
lizard
(Anolis carolinensis)
Reptilia MOB3C 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mob3c 34
  • 72.84 (n)
zebrafish
(Danio rerio)
Actinopterygii mob3c 34 35
  • 73.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mob3 35
  • 65 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T12B3.4 35
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2077 35
  • 66 (a)
OneToMany
Species where no ortholog for MOB3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOB3C Gene

ENSEMBL:
Gene Tree for MOB3C (if available)
TreeFam:
Gene Tree for MOB3C (if available)

Paralogs for MOB3C Gene

Paralogs for MOB3C Gene

(7) SIMAP similar genes for MOB3C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOB3C: view

Variants for MOB3C Gene

Sequence variations from dbSNP and Humsavar for MOB3C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1052301 -- 46,608,175(-) TGCTA(C/G)ATAGA upstream-variant-2KB, utr-variant-3-prime
rs10890408 -- 46,610,826(+) TGATA(A/G)AAGTT intron-variant
rs111321381 -- 46,612,038(+) ATGCC(C/T)GCTCA intron-variant
rs111360479 -- 46,610,575(+) ACAGG(A/G)TTTCT intron-variant
rs111448646 -- 46,613,026(+) GCCAG(C/G/T)GGTAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MOB3C Gene

Variant ID Type Subtype PubMed ID
nsv1009193 CNV gain 25217958
nsv522319 CNV loss 19592680

Variation tolerance for MOB3C Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.50; 71.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOB3C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOB3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOB3C Gene

Disorders for MOB3C Gene

Relevant External Links for MOB3C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOB3C

No disorders were found for MOB3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOB3C Gene

Publications for MOB3C Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64

Products for MOB3C Gene

Sources for MOB3C Gene

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