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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MOB3C Gene

protein-coding   GIFtS: 41
GCID: GC01M047075

MOB kinase activator 3C

(Previous names: MOB1, Mps One Binder kinase activator-like 2C (yeast) )
(Previous symbol: MOBKL2C)
  Search for MOB3C
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MOB3C    

Aliases
for MOB3C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
MOB Kinase Activator 3C1 2     MOB1, Mps One Binder Kinase Activator-Like 2C (Yeast)1
MOBKL2C1 2 3     MOB1, Mps One Binder Kinase Activator-Like 2C2
MOB1E1 2     Mps One Binder Kinase Activator-Like 2C3
Mob1 Homolog 2C2 3     

External Ids:    HGNC: 298001   Entrez Gene: 1489322   Ensembl: ENSG000001429617   UniProtKB: Q70IA83   

Export aliases for MOB3C gene to outside databases

Previous GC identifer: GC01M046443


Summaries
for MOB3C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MOB3C:
The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase
essential for spindle pole body duplication and mitotic checkpoint regulation. Alternatively spliced transcript
variants encoding distinct isoforms have been observed. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MOB3C_HUMAN, Q70IA8
Function: May regulate the activity of kinases (By similarity)




Genomic Views
for MOB3C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MOB3C
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MOB3C promoter sequence
   Search SABiosciences Chromatin IP Primers for MOB3C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOB3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p34.1

MOB3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOB3C gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M047075:  view genomic region     (about GC identifiers)

Start:
 47,073,387 bp from pter      End:
 47,082,563 bp from pter
Size:
 9,177 bases      Orientation:
 minus strand

Proteins
for MOB3C gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MOB3C_HUMAN, Q70IA8 (See protein sequence)
Recommended Name: MOB kinase activator 3C  
Size: 216 amino acids; 25623 Da
Sequence caution: Sequence=BAC03434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAC03752.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI14766.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D3DQ22 Q0VA98 Q5TC10 Q5TC11 Q8NAZ2 Q8NF28

Explore the universe of human proteins at neXtProt for MOB3C: NX_Q70IA8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q70IA8

    • MOB3C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_660322.2  NP_958805.1  

    ENSEMBL proteins: 
     ENSP00000271139   ENSP00000361008   ENSP00000315113  

    Human Recombinant Protein Products: 
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    Novus Biologicals MOB3C Lysates
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    Uscn Proteins for MOB3C


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    Uscn ELISAs and CLIAs for MOB3C

    Protein Domains /
    Families
    for MOB3C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MOB3C for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005301 Mob1_phocein

    Graphical View of Domain Structure for InterPro Entry Q70IA8

    ProtoNet protein and cluster: Q70IA8

    1 Blocks protein family: IPB005301 Mob1/phocein family

    UniProtKB/Swiss-Prot: MOB3C_HUMAN, Q70IA8
    Similarity: Belongs to the MOB1/phocein family


    Function
    for MOB3C gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MOB3C_HUMAN, Q70IA8
    Function: May regulate the activity of kinases (By similarity)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: MOB3C 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MOB3C (see all 7)
    OriGene shRNA RFP: MOB3C
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOB3C

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MOB3C (see all 4)
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    Cell Line
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    Search LifeMap BioReagents cell lines for MOB3C

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB3C

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--


    MOB3C for ontologies           About GeneDecksing



    Pathways & Interactions
    for MOB3C gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOB3C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for MOB3C (ENSP000002711394) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGLENSP000002947244STRING: ENSP00000294724
    ARHGEF10LENSP000003550604STRING: ENSP00000355060
    ATPAF1ENSP000003610054STRING: ENSP00000361005
    C1orf146ENSP000003594014STRING: ENSP00000359401
    C7orf57ENSP000003355004STRING: ENSP00000335500
    About this table

    Drugs & Compounds
    for MOB3C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MOB3C
    Search CenterWatch for drugs/clinical trials and news about MOB3C 

    Transcripts
    for MOB3C gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MOB3C gene (2 alternative transcripts): 
    NM_145279.4  NM_201403.2  

    Unigene Cluster for MOB3C:

    MOB kinase activator 3C
    Hs.632401  [show with all ESTs]
    Unigene Representative Sequence: NM_201403
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000271139(uc001cqe.4) ENST00000371940 ENST00000477318 ENST00000319928(uc001cqf.4)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOB3C
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MOB3C
    SwitchGear 3'UTR luciferase reporter plasmid: MOB3C 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MOB3C (see all 7)
    OriGene shRNA RFP: MOB3C
    OriGene siRNA: MOB3C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOB3C
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOB3C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOB3C

    Additional cDNA sequence: 

    AJ580637.1 AK091808.1 BC026078.2 BC121169.2 

    4 DOTS entries:

    DT.446849  DT.100694573  DT.40253763  DT.100768306 

    24/101 AceView cDNA sequences (see all 101):

    AI168118 CK299274 BM351999 BM994197 AK090453 AI400347 BM129727 CD672610 
    AI718901 BM980803 AI015655 CR599319 AI200492 NM_145279 BQ694103 AA972947 
    AA428947 BG058561 BF967872 BQ186330 CA449532 CK819657 CA313205 BQ011135 

    GeneLoc Exon Structure


    Expression
    for MOB3C gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MOB3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGATTCTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MOB3C expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MOB3C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MOB3C

    SOURCE GeneReport for Unigene cluster: Hs.632401
        SABiosciences Custom PCR Arrays for MOB3C
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MOB3C
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOB3C
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOB3C
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB3C

    Orthologs
    for MOB3C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MOB3C gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MOBKL2C1 MOB1, Mps One Binder kinase activator-like 2C (yeast) 80.61(n)
    84.09(a)    		   424615  XM_422452.3  XP_422452.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MOB3C6
    		 --
    		 81(a)
    		 1 ↔ 1
    		 4(112690969-112698580)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia AL962935.22   -- 74.13(n)    AL962935.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii mob3c1 MOB kinase activator 3C 73.15(n)
    80.56(a)    		   431738  NM_001002191.1  NP_001002191.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mob36
    		 --
    		 63(a)
    		 1 → many
    		 2L(10265336-10266570)
    worm
    (Caenorhabditis elegans)    		 Secernentea T12B3.46
    		 Protein T12B3.4
    		 44(a)
    		 1 → many
    		 IV(7384701-7388927)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G204306
    AT5G204406
    		 Mob1/phocein family protein
    		 45(a)
    39(a)
    		 many ↔ many
    many ↔ many
    		 5(6904705-6905391)
    5(6908646-6909996)


    ENSEMBL Gene Tree for MOB3C (if available)
    TreeFam Gene Tree for MOB3C (if available) 

    Paralogs
    for MOB3C gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MOB3C gene
    MOB22  MOB3A2  MOB3B2  MOB1B2  MOB1A2  
    7 SIMAP similar genes for MOB3C using alignment to 1 protein entry:     MOB3C_HUMAN:
    MOB3A    MOB3B    MOB1A    MOB1B    MOB4A    MOBKL1A
    MOB2

    MOB3C for paralogs           About GeneDecksing



    Genomic Variants
    for MOB3C gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/215 NCBI SNPs in MOB3C are shown (see all 215)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs118030691,2
    		H--45190630(+) CTCCCC/TTTCTC 2 -- ut31 trp30--------
    rs793299781,2
    		C,--45191318(+) GCGGGG/TCAGGA 4 T P mis10--------
    rs586927091,2
    		C,--45191571(+) TGAGAC/TGGAGT 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1113604791,2
    		--45191736(+) ACAGGG/ATTTCT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs125642871,2
    		H--45191998(+) ACGACC/ATAAAC 2 -- int14Minor allele frequency- A:0.00NS EA 416
    rs776940751,2
    		F,--45193069(+) TTCTCC/TCCTCA 2 -- int11Minor allele frequency- T:0.03WA 118
    rs746297281,2
    		--45193153(+) GGCTGA/GGCCCA 2 -- int10--------
    rs563881791,2
    		C,--45193957(+) AAATGG/CGGATG 2 -- int11Minor allele frequency- C:0.50WA 2
    rs785434911,2
    		F,--45193993(+) TGTCTA/GTATCA 2 -- int11Minor allele frequency- G:0.02EA 120
    rs1147572191,2
    		C,F,--45195943(+) GGCACA/GTATTT 2 -- int11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for MOB3C (47073387 - 47082563 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MOB3C: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MOB3C
    DNA2.0 Custom Variant and Variant Library Synthesis for MOB3C

    Disorders / Diseases
    for MOB3C gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for MOB3C gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MOB3C gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MOB3C)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    5. Molecular characterization of human homologs of yeast MOB1. (PubMed id 19739119)1 Chow A....Yang X. (2010)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    External Searches for MOB3C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MOB3C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 148932 HGNC: 29800 AceView: MOBKL2C Ensembl:ENSG00000142961 euGenes: HUgn148932
    ECgene: MOB3C H-InvDB: MOB3C

    Other Databases showing MOB3C gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MOB3C gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MOB3C Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MOB3C gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for MOB3C gene:
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    In Situ Hybridization Assays from
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     MOB3C Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MOB3C
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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