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Aliases for MOB3B Gene

Aliases for MOB3B Gene

  • MOB Kinase Activator 3B 2 3 5
  • Mps One Binder Kinase Activator-Like 2B 3 4
  • Mob1 Homolog 2b 3 4
  • MOBKL2B 3 4
  • MOB1, Mps One Binder Kinase Activator-Like 2B (Yeast) 2
  • Monopolar Spindle 1 Binding, MOB1, Domain Containing 3
  • MOB1, Mps One Binder Kinase Activator-Like 2B 3
  • Chromosome 9 Open Reading Frame 35 2
  • Monopolar Spindle 1 Binding 2
  • Domain Containing 2
  • C9orf35 3
  • MOB1D 3
  • MOB1 2

External Ids for MOB3B Gene

Previous HGNC Symbols for MOB3B Gene

  • MOBKL2B
  • C9orf35

Summaries for MOB3B Gene

Entrez Gene Summary for MOB3B Gene

  • The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the opposite strand as the interferon kappa precursor (IFNK) gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MOB3B Gene

MOB3B (MOB Kinase Activator 3B) is a Protein Coding gene. An important paralog of this gene is MOB1A.

UniProtKB/Swiss-Prot for MOB3B Gene

  • May regulate the activity of kinases.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB3B Gene

Genomics for MOB3B Gene

Regulatory Elements for MOB3B Gene

Enhancers for MOB3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MOB3B on UCSC Golden Path with GeneCards custom track

Promoters for MOB3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MOB3B on UCSC Golden Path with GeneCards custom track

Genomic Location for MOB3B Gene

Chromosome:
9
Start:
27,325,209 bp from pter
End:
27,529,852 bp from pter
Size:
204,644 bases
Orientation:
Minus strand

Genomic View for MOB3B Gene

Genes around MOB3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB3B Gene

Proteins for MOB3B Gene

  • Protein details for MOB3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TA1-MOB3B_HUMAN
    Recommended name:
    MOB kinase activator 3B
    Protein Accession:
    Q86TA1
    Secondary Accessions:
    • Q8NEB4
    • Q9H8V4

    Protein attributes for MOB3B Gene

    Size:
    216 amino acids
    Molecular mass:
    25464 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MOB3B Gene

Proteomics data for MOB3B Gene at MOPED

Post-translational modifications for MOB3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MOB3B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MOB3B Gene

Domains & Families for MOB3B Gene

Gene Families for MOB3B Gene

Protein Domains for MOB3B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MOB3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TA1

UniProtKB/Swiss-Prot:

MOB3B_HUMAN :
  • Belongs to the MOB1/phocein family.
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB3B: view

Function for MOB3B Gene

Molecular function for MOB3B Gene

UniProtKB/Swiss-Prot Function:
May regulate the activity of kinases.

Gene Ontology (GO) - Molecular Function for MOB3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MOB3B: view
genes like me logo Genes that share phenotypes with MOB3B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOB3B Gene

Localization for MOB3B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOB3B Gene COMPARTMENTS Subcellular localization image for MOB3B gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MOB3B Gene

Pathways & Interactions for MOB3B Gene

SuperPathways for MOB3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOB3B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MOB3B Gene

Drugs & Compounds for MOB3B Gene

(1) Drugs for MOB3B Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with MOB3B: view

Transcripts for MOB3B Gene

mRNA/cDNA for MOB3B Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MOB3B Gene

No ASD Table

Relevant External Links for MOB3B Gene

GeneLoc Exon Structure for
MOB3B
ECgene alternative splicing isoforms for
MOB3B

Expression for MOB3B Gene

mRNA expression in normal human tissues for MOB3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOB3B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.9).

Protein differential expression in normal tissues from HIPED for MOB3B Gene

This gene is overexpressed in Ovary (22.2), Retina (20.0), Fetal gut (9.5), and Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MOB3B Gene



SOURCE GeneReport for Unigene cluster for MOB3B Gene Hs.369022

genes like me logo Genes that share expression patterns with MOB3B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MOB3B Gene

Orthologs for MOB3B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOB3B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MOB3B 35
  • 92.28 (n)
  • 99.54 (a)
MOB3B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOB3B 35
  • 95.52 (n)
  • 99.07 (a)
MOB3B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mob3b 35
  • 90.59 (n)
  • 98.15 (a)
Mob3b 16
Mob3b 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MOBKL2B 35
  • 99.85 (n)
  • 100 (a)
MOB3B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mob3b 35
  • 91.51 (n)
  • 98.61 (a)
oppossum
(Monodelphis domestica)
Mammalia MOB3B 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MOB3B 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOBKL2B 35
  • 82.87 (n)
  • 93.98 (a)
MOB3B 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MOB3B 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14298 35
zebrafish
(Danio rerio)
Actinopterygii mob1bb 36
  • 53 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Mob3 36
  • 66 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T12B3.4 36
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 36
  • 26 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9757 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2077 36
  • 68 (a)
OneToMany
Species with no ortholog for MOB3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MOB3B Gene

ENSEMBL:
Gene Tree for MOB3B (if available)
TreeFam:
Gene Tree for MOB3B (if available)

Paralogs for MOB3B Gene

Paralogs for MOB3B Gene

(8) SIMAP similar genes for MOB3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOB3B: view

Variants for MOB3B Gene

Sequence variations from dbSNP and Humsavar for MOB3B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs700793 -- 27,521,531(-) AAAAA(C/T)AGATA intron-variant
rs700794 -- 27,521,255(-) ATATT(A/G)TATTC intron-variant
rs700795 -- 27,520,510(-) ATGTA(C/T)CTCAA intron-variant
rs700796 -- 27,518,962(-) GTATT(G/T)CTTGG intron-variant
rs725804 -- 27,458,941(+) TGAGG(A/C)TGTCT intron-variant

Variation tolerance for MOB3B Gene

Residual Variation Intolerance Score: 30.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MOB3B Gene

Disorders for MOB3B Gene

Relevant External Links for MOB3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOB3B

No disorders were found for MOB3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOB3B Gene

Publications for MOB3B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer. (PMID: 23376709) Kerns S.L. … Rosenstein B.S. (J. Urol. 2013) 3
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. Molecular characterization of human homologs of yeast MOB1. (PMID: 19739119) Chow A. … Yang X. (Int. J. Cancer 2010) 3

Products for MOB3B Gene

Sources for MOB3B Gene

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