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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MOB3B Gene

protein-coding GIFtS: 44
GCID: GC09M027316

MOB kinase activator 3B

(Previous names: MOB1, Mps One Binder kinase activator-like 2B (yeast),...)
(Previous symbols: MOBKL2B, C9orf35)

Explore 8 diseases affiliated with
MOB3B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
MOB Kinase Activator 3B¹ ²		FLJ13204¹
MOBKL2B¹ ² ³		Chromosome 9 Open Reading Frame 35¹
C9orf35¹ ²		MOB1, Mps One Binder Kinase Activator-Like 2B (Yeast)¹
MOB1D¹ ²		MOB1, Mps One Binder Kinase Activator-Like 2B²
Mob1 Homolog 2b² ³		Monopolar Spindle 1 Binding, MOB1, Domain Containing²
Mps One Binder Kinase Activator-Like 2B² ³

External Ids:	HGNC: 23825¹	Entrez Gene: 79817²	Ensembl: ENSG00000120162⁷	UniProtKB: Q86TA1³

Export aliases for MOB3B gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MOB3B:

The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein

kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the

opposite strand as the interferon kappa precursor (IFNK) gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MOB3B_HUMAN, Q86TA1

Function: May regulate the activity of kinases (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for MOB3B
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MOB3B promoter sequence

Search SABiosciences Chromatin IP Primers for MOB3B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOB3B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21.2 Ensembl cytogenetic band: 9p21.2 HGNC cytogenetic band: 9p21.1

MOB3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOB3B gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M027316: view genomic region (about GC identifiers)

Start:	27,325,207 bp from pter	End:	27,529,850 bp from pter
Size:	204,644 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MOB3B_HUMAN, Q86TA1 (See protein sequence)

Recommended Name: MOB kinase activator 3B

Size: 216 amino acids; 25464 Da

Secondary accessions: Q8NEB4 Q9H8V4

Explore the universe of human proteins at neXtProt for MOB3B: NX_Q86TA1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86TA1

MOB3B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_079037.3

ENSEMBL proteins:

ENSP00000262244

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MOB3B for domains About GeneDecksing

1 InterPro domain/family:

IPR005301 Mob1_phocein

Graphical View of Domain Structure for InterPro Entry Q86TA1

ProtoNet protein and cluster: Q86TA1

1 Blocks protein family: IPB005301 Mob1/phocein family

UniProtKB/Swiss-Prot: MOB3B_HUMAN, Q86TA1

Similarity: Belongs to the MOB1/phocein family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MOB3B_HUMAN, Q86TA1

Function: May regulate the activity of kinases (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19060904
GO:0046872	metal ion binding	IEA	--

MOB3B for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MOB3B

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB3B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MOB3B

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/10 Interacting proteins for MOB3B (Q86TA1^{1, 2, 3} ENSP00000262244⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NT5C2	P49902¹^,²^,³, ENSP00000339479⁴	EBI-751703,EBI-742084 MINT-68246 I2D: score=5 STRING: ENSP00000339479
PPBP	P02775²^,³, ENSP00000296028⁴	MINT-8263291 I2D: score=2 STRING: ENSP00000296028
CNKSR2	Q8WXI2³, ENSP00000368824⁴	I2D: score=2 STRING: ENSP00000368824
MAPK14	Q16539³, ENSP00000229794⁴	I2D: score=3 STRING: ENSP00000229794
LATS2	ENSP00000372035⁴	STRING: ENSP00000372035

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MOB3B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MOB3B
1 PharmGKB related drug/compound annotation for MOB3B gene About this table

Drug/compound	PharmGKB Annotation
Tumor necrosis factor alpha (TNF-alpha) inhibitors	CA

Search CenterWatch for drugs/clinical trials and news about MOB3B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MOB3B gene:

NM_024761.4

Unigene Clusters for MOB3B:

MOB kinase activator 3B

Hs.369022 [show with all ESTs], Hs.690014

Unigene Representative Sequences: NM_024761, AK172755

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000262244(uc003zqn.3)

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Additional cDNA sequence: AK172755.1

5 DOTS entries:

DT.442851 DT.422980 DT.91641026 DT.91881446 DT.100735315

4 AceView cDNA sequences:

AK022201 AU121522 AU147316 BM926813

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MOB3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTAACCATT

About this image

MOB3B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MOB3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MOB3B

SOURCE GeneReport for Unigene clusters: Hs.369022 Hs.690014

SABiosciences Custom PCR Arrays for MOB3B

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB3B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOB3B gene from 6/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MOBKL2B¹	MOB1, Mps One Binder kinase activator-like 2B (yeast) less	82.78(n) 94.26(a)		431645 XM_429197.3 XP_429197.3
lizard (Anolis carolinensis)	Reptilia	MOB3B⁶	--	96(a)	1 ↔ 1	2(64477147-64529702)
African clawed frog (Xenopus laevis)	Amphibia	Xl.14298²	Xenopus laevis transcribed sequence with moderate similarity to protein refNP_570719.1 (H.sapiens) MOB-LAK [Homo sapiens] less	76.06(n)		CA971174.1
fruit fly (Drosophila melanogaster)	Insecta	Mob3¹	CG4946-PA	64.27(n) 68.42(a)		34372 NM_135520.3 NP_609364.1
worm (Caenorhabditis elegans)	Secernentea	T12B3.4¹	Protein T12B3.4	64.07(n) 67.32(a)		177511 NM_068778.2 NP_501179.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G20430⁶ AT5G20440⁶	Mob1/phocein family protein	43(a) 42(a)	many ↔ many many ↔ many	5(6904705-6905391) 5(6908646-6909996)

ENSEMBL Gene Tree for MOB3B (if available)
TreeFam Gene Tree for MOB3B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MOB3B gene

MOB3C² MOB2² MOB3A² MOB1B² MOB1A²

8 SIMAP similar genes for MOB3B using alignment to 1 protein entry: MOB3B_HUMAN:

MOB3A MOB3C MOBKL1A MOB1B DKFZp686N2312 MOB4A

MOB1A MOB2

MOB3B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150542144^1,2		--	27324944(+)	`ACTGTC/TTAACC`	1	--	ds500¹		0	--	--	--	--
rs116387018^1,2	F	--	27324966(+)	`AATGAG/CCTGGG`	1	--	ds500¹		1		WA	118
rs193046267^1,2		--	27325001(+)	`AACTCA/GCCTTC`	1	--	ds500¹		0	--	--	--	--
rs72617313^1,2		--	27325018(+)	`GATCTC/TGCTGG`	1	--	ds500¹		0	--	--	--	--
rs184747579^1,2		--	27325035(+)	`CAGACA/CGGAGC`	1	--	ds500¹		0	--	--	--	--
rs149688675^1,2		--	27325036(+)	`AGACCG/TGAGCT`	1	--	ds500¹		0	--	--	--	--
rs79600156^1,2	C	--	27325069(+)	`AGCCAC/TCCATG`	1	--	ds500¹		0	--	--	--	--
rs113158798^1,2		--	27325242(+)	`TTGAAT/AACCCA`	1	--	ut3¹		2		CSA WA	119
rs7049080^1,2	C,F,H	--	27325452(+)	`ACAGGT/CGAATT`	1	--	ut3¹ ese³		27		NS EA NA WA CSA	1989
rs147782374^1,2		--	27325469(+)	`TTAGAA/GATGGA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MOB3B (27325207 - 27529850 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MOB3B: --

SABiosciences Cancer Mutation PCR Assays

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DNA2.0 Custom Variant and Variant Library Synthesis for MOB3B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MOB3B for disorders About GeneDecksing

8 diseases for MOB3B: About MalaCards

amyotrophic lateral sclerosis lateral sclerosis intrahepatic cholangiocarcinoma rheumatoid arthritis

cholangiocarcinoma hepatitis b arthritis hepatitis

Export disorders for MOB3B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MOB3B gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with MOB3B)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Lack of replication of genetic predictors for the rhe umatoid arthritis response to anti-TNF treatments: a prospective case-only stud y. (PubMed id 20423481)¹ Suarez-Gestal M....Gonzalez A. (2010)
A human MAP kinase interactome. (PubMed id 20936779)¹ Bandyopadhyay S....Ideker T. (2010)
Molecular characterization of human homologs of yeast MOB1. (PubMed id 19739119)¹ Chow A....Yang X. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79817	HGNC: 23825	AceView: MOBKL2B.1	Ensembl:ENSG00000120162	euGenes: HUgn79817
ECgene: MOB3B	H-InvDB: MOB3B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MOB3B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MOB3B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MOB3B gene:
Search GeneIP for patents involving MOB3B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

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	OriGene Antibodies for MOB3B		OriGene shRNA RFP for MOB3B
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MOB3B		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MOB3B
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	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MOB3B
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	GenScript Custom Purified and Recombinant Proteins Services for MOB3B		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for MOB3B
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	GenScript Custom overexpressing Cell Line Services for MOB3B		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOB3B

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MOB3B

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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MOB3B Gene

MOB kinase activator 3B

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MOB3B Gene

MOB kinase activator 3B

Aliasesfor MOB3B gene

Summariesfor MOB3B gene

Genomic Viewsfor MOB3B gene

Proteinsfor MOB3B gene

Protein Domains /Familiesfor MOB3B gene

Functionfor MOB3B gene

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Specialized Databases showing MOB3B gene

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Summaries
for MOB3B gene

Genomic Views
for MOB3B gene

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for MOB3B gene

Protein Domains /
Families
for MOB3B gene

Function
for MOB3B gene

Pathways & Interactions
for MOB3B gene

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for MOB3B gene

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for MOB3B gene

Expression
for MOB3B gene

Orthologs
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Intellectual Property
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