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Aliases for MOB3B Gene

Aliases for MOB3B Gene

  • MOB Kinase Activator 3B 2 3 5
  • Monopolar Spindle 1 Binding, MOB1, Domain Containing 2 3
  • Mps One Binder Kinase Activator-Like 2B 3 4
  • Mob1 Homolog 2b 3 4
  • MOBKL2B 3 4
  • MOB1, Mps One Binder Kinase Activator-Like 2B (Yeast) 2
  • MOB1, Mps One Binder Kinase Activator-Like 2B 3
  • Chromosome 9 Open Reading Frame 35 2
  • C9orf35 3
  • MOB1D 3

External Ids for MOB3B Gene

Previous HGNC Symbols for MOB3B Gene

  • C9orf35

Summaries for MOB3B Gene

Entrez Gene Summary for MOB3B Gene

  • The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the opposite strand as the interferon kappa precursor (IFNK) gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MOB3B Gene

MOB3B (MOB Kinase Activator 3B) is a Protein Coding gene. An important paralog of this gene is MOB3A.

UniProtKB/Swiss-Prot for MOB3B Gene

  • May regulate the activity of kinases.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB3B Gene

Genomics for MOB3B Gene

Regulatory Elements for MOB3B Gene

Enhancers for MOB3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G027365 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.3 +160.6 160580 8.5 TBP HDGF PKNOX1 ZSCAN4 FEZF1 RCOR1 FOS RELB ETV6 IKZF2 MOB3B IFT74 ENSG00000237734 EQTN IFNK C9orf72 PLAA GC09M027375
GH09G027538 1.4 Ensembl ENCODE dbSUPER 19.3 -10.1 -10062 2.8 ELF3 FOXA2 PKNOX1 RFX5 YY1 RARA RCOR1 FOS RELB CREM MOB3B C9orf72 EQTN
GH09G027332 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14 +196.4 196431 1.3 CTCF TEAD4 ZNF384 CHD7 ZNF2 RAD21 ZNF207 SMC3 DEK ZNF263 MOB3B IFNK EQTN IFT74 C9orf72 GC09M027375
GH09G027458 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +67.4 67445 7.3 HDAC1 PKNOX1 FOXA2 TAL1 JUN FOSL1 TCF12 FOXM1 FOXK2 NCOR1 C9orf72 MOB3B ENSG00000237734 IFNK EQTN LOC105376001
GH09G027351 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +177.9 177900 1.6 PKNOX1 EED ETV6 RELB IKZF2 MTA2 BHLHE40 DPF2 TBX21 EP300 IFT74 MOB3B IFNK C9orf72 PLAA GC09M027375 EQTN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MOB3B on UCSC Golden Path with GeneCards custom track

Promoters for MOB3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234205 852 2001 PKNOX1 SIN3A ZNF48 GLIS2 ZNF207 ZNF143 ZNF263 SP3 REST SMARCB1

Genomic Location for MOB3B Gene

27,325,209 bp from pter
27,529,852 bp from pter
204,644 bases
Minus strand

Genomic View for MOB3B Gene

Genes around MOB3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB3B Gene

Proteins for MOB3B Gene

  • Protein details for MOB3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MOB kinase activator 3B
    Protein Accession:
    Secondary Accessions:
    • Q8NEB4
    • Q9H8V4

    Protein attributes for MOB3B Gene

    216 amino acids
    Molecular mass:
    25464 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MOB3B Gene

Post-translational modifications for MOB3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MOB3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MOB3B Gene

Domains & Families for MOB3B Gene

Gene Families for MOB3B Gene

Protein Domains for MOB3B Gene


Suggested Antigen Peptide Sequences for MOB3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MOB1/phocein family.
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB3B: view

Function for MOB3B Gene

Molecular function for MOB3B Gene

UniProtKB/Swiss-Prot Function:
May regulate the activity of kinases.

Gene Ontology (GO) - Molecular Function for MOB3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB3B: view
genes like me logo Genes that share phenotypes with MOB3B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOB3B Gene

Localization for MOB3B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOB3B gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MOB3B Gene

Pathways & Interactions for MOB3B Gene

SuperPathways for MOB3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOB3B Gene


No data available for Pathways by source and SIGNOR curated interactions for MOB3B Gene

Drugs & Compounds for MOB3B Gene

(1) Drugs for MOB3B Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with MOB3B: view

Transcripts for MOB3B Gene

mRNA/cDNA for MOB3B Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOB3B Gene

No ASD Table

Relevant External Links for MOB3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MOB3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOB3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOB3B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.9).

Protein differential expression in normal tissues from HIPED for MOB3B Gene

This gene is overexpressed in Ovary (22.2), Retina (20.0), Fetal gut (9.5), and Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MOB3B Gene

NURSA nuclear receptor signaling pathways regulating expression of MOB3B Gene:


SOURCE GeneReport for Unigene cluster for MOB3B Gene:


Evidence on tissue expression from TISSUES for MOB3B Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with MOB3B: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOB3B Gene

Orthologs for MOB3B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOB3B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MOB3B 35
  • 100 (a)
  • 99.85 (n)
(Monodelphis domestica)
Mammalia MOB3B 35
  • 99 (a)
(Canis familiaris)
Mammalia MOB3B 34 35
  • 95.52 (n)
(Bos Taurus)
Mammalia MOB3B 34 35
  • 92.28 (n)
(Rattus norvegicus)
Mammalia Mob3b 34
  • 91.51 (n)
(Mus musculus)
Mammalia Mob3b 34 16 35
  • 90.59 (n)
(Ornithorhynchus anatinus)
Mammalia MOB3B 35
  • 85 (a)
(Gallus gallus)
Aves MOB3B 35
  • 94 (a)
  • 82.87 (n)
(Anolis carolinensis)
Reptilia MOB3B 35
  • 96 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14298 34
(Danio rerio)
Actinopterygii mob1bb 35
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mob3 35
  • 66 (a)
(Caenorhabditis elegans)
Secernentea T12B3.4 35
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 35
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2077 35
  • 68 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9757 34
Species where no ortholog for MOB3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MOB3B Gene

Gene Tree for MOB3B (if available)
Gene Tree for MOB3B (if available)

Paralogs for MOB3B Gene

Paralogs for MOB3B Gene

(8) SIMAP similar genes for MOB3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOB3B: view

Variants for MOB3B Gene

Sequence variations from dbSNP and Humsavar for MOB3B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000014305 -- 27,473,564(+) ACACA(A/G)GGACC intron-variant
rs1000015435 -- 27,369,123(+) ATGAA(A/C/T)TTCAT intron-variant
rs1000034664 -- 27,474,269(+) TGGGT(C/G)CTTTT intron-variant
rs1000059670 -- 27,424,700(+) GATAA(C/T)GCAAT intron-variant
rs1000073314 -- 27,332,751(+) CATCT(C/T)TACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOB3B Gene

Variant ID Type Subtype PubMed ID
dgv480e215 CNV deletion 23714750
esv1113815 CNV insertion 17803354
esv2131938 CNV deletion 18987734
esv2664439 CNV deletion 23128226
esv2738322 CNV deletion 23290073
esv2738323 CNV deletion 23290073
esv3428618 CNV insertion 20981092
esv3573190 CNV loss 25503493
esv3620129 CNV loss 21293372
esv3620130 CNV loss 21293372
nsv1015259 CNV gain 25217958
nsv1019688 CNV loss 25217958
nsv466337 CNV loss 19166990
nsv473199 CNV novel sequence insertion 20440878
nsv613949 CNV loss 21841781

Variation tolerance for MOB3B Gene

Residual Variation Intolerance Score: 30.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOB3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOB3B Gene

Disorders for MOB3B Gene

Relevant External Links for MOB3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MOB3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOB3B Gene

Publications for MOB3B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics. (PMID: 26130958) Kim E.A. … Kim W.J. (J. Korean Med. Sci. 2015) 3 64
  5. A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer. (PMID: 23376709) Kerns S.L. … Rosenstein B.S. (J. Urol. 2013) 3 64

Products for MOB3B Gene

Sources for MOB3B Gene

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