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MOB3B Gene

protein-coding   GIFtS: 42
GCID: GC09M027316

MOB Kinase Activator 3B

(Previous names: MOB1, Mps One Binder kinase activator-like 2B (yeast), chromosome...)
(Previous symbols: MOBKL2B, C9orf35)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MOB Kinase Activator 3B1 2     Domain Containing1
MOBKL2B1 2 3     MOB1, Mps One Binder Kinase Activator-Like 2B (Yeast)1
C9orf351 2     Monopolar Spindle 1 Binding1
Mob1 Homolog 2b2 3     MOB1D2
Mps One Binder Kinase Activator-Like 2B2 3     MOB1, Mps One Binder Kinase Activator-Like 2B2
MOB11     Monopolar Spindle 1 Binding, MOB1, Domain Containing2
Chromosome 9 Open Reading Frame 351     

External Ids:    HGNC: 238251   Entrez Gene: 798172   Ensembl: ENSG000001201627   UniProtKB: Q86TA13   

Export aliases for MOB3B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MOB3B Gene:
The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein
kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the
opposite strand as the interferon kappa precursor (IFNK) gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MOB3B Gene:
MOB3B (MOB kinase activator 3B) is a protein-coding gene. An important paralog of this gene is MOB3C.

UniProtKB/Swiss-Prot: MOB3B_HUMAN, Q86TA1
Function: May regulate the activity of kinases (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008413.19  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MOB3B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOB3B promoter sequence
   Search Chromatin IP Primers for MOB3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MOB3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21.2   Ensembl cytogenetic band:  9p21.2   HGNC cytogenetic band: 9p21.1

MOB3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOB3B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M027316:  view genomic region     (about GC identifiers)

Start:
27,325,207 bp from pter      End:
27,529,850 bp from pter
Size:
204,644 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MOB3B_HUMAN, Q86TA1 (See protein sequence)
Recommended Name: MOB kinase activator 3B  
Size: 216 amino acids; 25464 Da
Secondary accessions: Q8NEB4 Q9H8V4

Explore the universe of human proteins at neXtProt for MOB3B: NX_Q86TA1

Explore proteomics data for MOB3B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MOB3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079037.3  
    ENSEMBL proteins: 
     ENSP00000262244  

    MOB3B Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for MOB3B (4 products) 

     
    Search antibodies-online for peptides for MOB3B

    MOB3B Antibody Products:

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    antibodies-online antibodies for MOB3B (33 products) 

    MOB3B Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for MOB3B 
    antibodies-online kits for MOB3B (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MOB: MOB kinase activators

    1 InterPro protein domain:
     IPR005301 Mob1_phocein

    Graphical View of Domain Structure for InterPro Entry Q86TA1

    ProtoNet protein and cluster: Q86TA1

    1 Blocks protein domain: IPB005301 Mob1/phocein family

    UniProtKB/Swiss-Prot: MOB3B_HUMAN, Q86TA1
    Similarity: Belongs to the MOB1/phocein family


    Find genes that share domains with MOB3B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOB3B_HUMAN, Q86TA1
    Function: May regulate the activity of kinases (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with MOB3B           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MOB3B

    miRNA
    Products:
        
    miRTarBase miRNAs that target MOB3B:
    hsa-mir-122-5p (MIRT023324), hsa-mir-128-3p (MIRT021972), hsa-mir-98-5p (MIRT027623), hsa-mir-181a-5p (MIRT025174)

    Block miRNA regulation of human, mouse, rat MOB3B using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat MOB3B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB3B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MOB3B
    Interactions:

        Search GeneGlobe Interaction Network for MOB3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MOB3B (Q86TA11, 2, 3 ENSP000002622444) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NT5C2P499021, 2, 3, ENSP000003394794EBI-751703,EBI-742084 MINT-68246 I2D: score=5 STRING: ENSP00000339479
    PPBPP027752, 3, ENSP000002960284MINT-8263291 I2D: score=2 STRING: ENSP00000296028
    CNKSR2Q8WXI23, ENSP000003688244I2D: score=2 STRING: ENSP00000368824
    MAPK14Q165393, ENSP000002297944I2D: score=3 STRING: ENSP00000229794
    LATS2ENSP000003720354STRING: ENSP00000372035
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MOB3B

    1 PharmGKB related drug/compound annotation for MOB3B gene    About this table
    Drug/compound PharmGKB Annotation
    Tumor necrosis factor alpha (TNF-alpha) inhibitorsCA  



    Find genes that share compounds with MOB3B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MOB3B gene: 
    NM_024761.4  

    Unigene Cluster for MOB3B:

    MOB kinase activator 3B
    Hs.369022  [show with all ESTs]
    Unigene Representative Sequence: NM_024761
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262244(uc003zqn.3) ENST00000603061
    miRNA
    Products:
         
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    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for MOB3B
    OriGene qSTAR qPCR primer pairs in human, mouse for MOB3B
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MOB3B
      QuantiTect SYBR Green Assays in human, mouse, rat MOB3B
      QuantiFast Probe-based Assays in human, mouse, rat MOB3B

    Additional mRNA sequence: 

    AJ580636.1 AK023266.1 AL832572.2 BC033027.1 CR457307.1 

    4 DOTS entries:

    DT.442851  DT.422980  DT.91641026  DT.100735315 

    4 AceView cDNA sequences:

    AU121522 AK022201 AU147316 BM926813 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MOB3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTAACCATT
    MOB3B Expression
    About this image


    MOB3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Skeletal Muscle (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
    MOB3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MOB3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369022
        Custom PCR Arrays for MOB3B
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MOB3B gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mob3b1 , 5 MOB kinase activator 3B1, 5 90.59(n)1
    98.15(a)1
      4 (16.86 cM)5
    2149441  NM_178061.51  NP_835162.11 
     349490745 
    chicken
    (Gallus gallus)
    Aves MOBKL2B1 MOB1, Mps One Binder kinase activator-like 2B (yeast) 82.87(n)
    93.98(a)
      431645  XM_004949594.1  XP_004949651.1 
    lizard
    (Anolis carolinensis)
    Reptilia MOB3B6
    MOB kinase activator 3B
    96(a)
    1 ↔ 1
    2(64416410-64534365)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.142982 Xenopus laevis transcribed sequence with moderate similarity more 76.06(n)    CA971174.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mob1bb6
    MOB kinase activator 1Bb
    53(a)
    many ↔ many
    21(5882661-5895037) ENSDARG00000012953
    fruit fly
    (Drosophila melanogaster)
    Insecta Mob36
    --
    66(a)
    1 → many
    2L(10265336-10266570)
    worm
    (Caenorhabditis elegans)
    Secernentea T12B3.46
    Protein T12B3.4 (T12B3.4) mRNA, complete cds
    48(a)
    1 → many
    IV(7384712-7388938) WBGene00020447
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MOB16
    Component of the mitotic exit network; associates ...
    26(a)
    1 → many
    IX(166415-167444) YIL106W


    ENSEMBL Gene Tree for MOB3B (if available)
    TreeFam Gene Tree for MOB3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MOB3B gene
    MOB3C2  MOB22  MOB3A2  MOB1B2  MOB1A2  
    8 SIMAP similar genes for MOB3B using alignment to 1 protein entry:     MOB3B_HUMAN:
    MOB3A    MOB3C    MOBKL1A    MOB1B    DKFZp686N2312    MOB4A
    MOB1A    MOB2

    Find genes that share paralogs with MOB3B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MOB3B (see all 4310)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1505421441,2
    --27324944(+) ACTGTC/TTAACC 1 -- ds50010--------
    rs1163870181,2
    C,F--27324966(+) AATGAG/CCTGGG 1 -- ds50011Minor allele frequency- C:0.06WA 118
    rs1930462671,2
    C--27325001(+) AACTCA/GCCTTC 1 -- ds50010--------
    rs726173131,2
    --27325018(+) GATCTC/TGCTGG 1 -- ds50010--------
    rs1847475791,2
    C--27325035(+) CAGACA/CGGAGC 1 -- ds50010--------
    rs1496886751,2
    --27325036(+) AGACCG/TGAGCT 1 -- ds50010--------
    rs796001561,2
    C--27325069(+) AGCCAC/TCCATG 1 -- ds50010--------
    rs1131587981,2
    C,F--27325242(+) TTGAAT/AACCCA 1 -- ut312Minor allele frequency- A:0.07CSA WA 119
    rs70490801,2
    C,F,H--27325452(+) ACAGGT/CGAATT 1 -- ut31 ese327Minor allele frequency- C:0.03NS EA NA WA CSA 1989
    rs1477823741,2
    --27325469(+) TTAGAA/GATGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MOB3B (27325207 - 27529850 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MOB3B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MOB3B
    DNA2.0 Custom Variant and Variant Library Synthesis for MOB3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MOB3B gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with MOB3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer. (PubMed id 23376709)1 Kerns S.L....Rosenstein B.S. (J. Urol. 2013)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    7. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study. (PubMed id 20423481)1 Suarez-Gestal M....Gonzalez A. (amp 2010)
    10. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79817 HGNC: 23825 AceView: MOBKL2B.1 Ensembl:ENSG00000120162 euGenes: HUgn79817
    ECgene: MOB3B H-InvDB: MOB3B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MOB3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MOB3B gene:
    Search GeneIP for patents involving MOB3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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