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MOB3A Gene

protein-coding   GIFtS: 39
GCID: GC19M002072

MOB Kinase Activator 3A

(Previous names: MOB1, Mps One Binder kinase activator-like 2A (yeast))
(Previous symbol: MOBKL2A)
  Search for MOB3A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MOB Kinase Activator 3A1 2     MOB-LAK2 3
MOBKL2A1 2 3     MOB1, Mps One Binder Kinase Activator-Like 2A (Yeast)1
MOB LAK1 2     MOB1C2
Mob1 Homolog 2A2 3     MOB1, Mps One Binder Kinase Activator-Like 2A2
Mps One Binder Kinase Activator-Like 2A2 3     moblak2

External Ids:    HGNC: 298021   Entrez Gene: 1263082   Ensembl: ENSG000001720817   UniProtKB: Q96BX83   

Export aliases for MOB3A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MOB3A Gene:
MOB3A (MOB kinase activator 3A) is a protein-coding gene. An important paralog of this gene is MOB3C.

UniProtKB/Swiss-Prot: MOB3A_HUMAN, Q96BX8
Function: May regulate the activity of kinases (By similarity)

Gene Wiki entry for MOB3A (MOBKL2A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MOB3A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOB3A promoter sequence
   Search Chromatin IP Primers for MOB3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MOB3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

MOB3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOB3A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M002072:  view genomic region     (about GC identifiers)

Start:
2,071,035 bp from pter      End:
2,096,672 bp from pter
Size:
25,638 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MOB3A_HUMAN, Q96BX8 (See protein sequence)
Recommended Name: MOB kinase activator 3A  
Size: 217 amino acids; 25464 Da
Sequence caution: Sequence=AAC27672.1; Type=Erroneous gene model prediction; Sequence=BAB84554.1;
Type=Miscellaneous discrepancy; Note=Chimera. There is an inclusion of DNA from another gene in position 141;
Secondary accessions: B3KTF1 O75249 Q8TF69

Explore the universe of human proteins at neXtProt for MOB3A: NX_Q96BX8

Explore proteomics data for MOB3A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys7
  • Modification sites at PhosphoSitePlus

  • See MOB3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_570719.1  
    ENSEMBL proteins: 
     ENSP00000349575   ENSP00000466249   ENSP00000468628   ENSP00000466199   ENSP00000465662  
     ENSP00000467581   ENSP00000468726   ENSP00000466080  

    MOB3A Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for MOB3A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MOB: MOB kinase activators

    1 InterPro protein domain:
     IPR005301 Mob1_phocein

    Graphical View of Domain Structure for InterPro Entry Q96BX8

    ProtoNet protein and cluster: Q96BX8

    1 Blocks protein domain: IPB005301 Mob1/phocein family

    UniProtKB/Swiss-Prot: MOB3A_HUMAN, Q96BX8
    Similarity: Belongs to the MOB1/phocein family


    Find genes that share domains with MOB3A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOB3A_HUMAN, Q96BX8
    Function: May regulate the activity of kinases (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with MOB3A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MOB3A:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MOB3A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MOB3A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MOB3A
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    miRNA
    Products:
        
    miRTarBase miRNAs that target MOB3A:
    hsa-mir-335-5p (MIRT018721), hsa-mir-186-5p (MIRT045023)

    Block miRNA regulation of human, mouse, rat MOB3A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MOB3A
    SwitchGear 3'UTR luciferase reporter plasmidMOB3A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MOB3A

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    Addgene plasmids for MOB3A 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB3A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--

    Find genes that share ontologies with MOB3A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MOB3A
    Interactions:

        Search GeneGlobe Interaction Network for MOB3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for MOB3A (Q96BX83 ENSP000003495754) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC42P609533I2D: score=2 
    GRB2P629933I2D: score=2 
    LATS2ENSP000003720354STRING: ENSP00000372035
    LATS1ENSP000002533394STRING: ENSP00000253339
    SLMAPENSP000002959514STRING: ENSP00000295951
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MOB3A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MOB3A gene: 
    NM_130807.2  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357066(uc002luu.3 uc002luv.3) ENST00000592143 ENST00000592280
    ENST00000591638 ENST00000591326 ENST00000591236 ENST00000589902 ENST00000586676
    ENST00000588048
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMOB3A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MOB3A
    Predesigned siRNA for gene silencing in human, mouse, rat MOB3A
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    Addgene plasmids for MOB3A 
    Primer
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    OriGene qPCR primer pairs and template standards for MOB3A
    OriGene qSTAR qPCR primer pairs in human, mouse for MOB3A
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MOB3A
      QuantiTect SYBR Green Assays in human, mouse, rat MOB3A
      QuantiFast Probe-based Assays in human, mouse, rat MOB3A

    Selected AceView cDNA sequences (see all 562):

    BQ949307 BQ961866 BF205264 BU729077 BG387839 BF794610 AI625755 CA309374 
    BQ932076 BU543166 CA394240 BE269262 AK095471 BU184330 CA306921 BM461766 
    AI582967 BU176978 BU848640 AA312481 AI421598 BP338446 BU164345 BQ676111 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MOB3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MOB3A Expression
    About this image

    MOB3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MOB3A Protein Expression
        Custom PCR Arrays for MOB3A
    Primer
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    OriGene qPCR primer pairs and template standards for MOB3A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB3A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MOB3A gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mob3a1 , 5 MOB kinase activator 3A1, 5 85.41(n)1
    94.47(a)1
      10 (39.72 cM)5
    2082281  NM_172457.21  NP_766045.21 
     806852565 
    chicken
    (Gallus gallus)
    Aves LOC1008571821 mps one binder kinase activator-like 2A-like 87.26(n)
    91.04(a)
      100857182  XM_003642855.2  XP_003642903.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mob3a1 MOB kinase activator 3A 75.15(n)
    89.35(a)
      496492  NM_001011080.1  NP_001011080.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc69e012 wufc69e01 80.62(n)   325366  BC049527.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mob31 Mob3 63.38(n)
    66.67(a)
      34372  NM_135520.4  NP_609364.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T12B3.41 T12B3.4 60.81(n)
    63.9(a)
      177511  NM_068778.3  NP_501179.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MOB16
    Component of the mitotic exit network; associates ...
    26(a)
    1 → many
    IX(166415-167444) YIL106W


    ENSEMBL Gene Tree for MOB3A (if available)
    TreeFam Gene Tree for MOB3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MOB3A gene
    MOB3C2  MOB3B2  MOB22  MOB1B2  MOB1A2  
    8 SIMAP similar genes for MOB3A using alignment to 7 protein entries:     MOB3A_HUMAN (see all proteins):
    MOB3C    DKFZp686N2312    MOB3B    MOBKL1A    MOB4A    MOB1B
    MOB1A    MOB2

    Find genes that share paralogs with MOB3A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MOB3A (see all 632)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998568881,2
    C--2070535(-) CCTTTC/TTTTTT 1 -- int10--------
    rs1148774311,2
    F--2070572(+) AATAAA/GAAGTT 1 -- int11Minor allele frequency- G:0.02WA 118
    rs2011175611,2
    --2070710(+) CTTCA-/TTTTC 
            
    TTTTC
    1 -- int10--------
    rs1170240391,2
    C,F--2070728(+) TCTTTT/CTTTTT 1 -- int11Minor allele frequency- C:0.04NA 120
    rs1838503191,2
    --2070729(+) CTTTTC/TTTTTT 1 -- int10--------
    rs1481049071,2
    C--2070764(+) TCACAC/TAGGCT 1 -- int10--------
    rs621283651,2
    C--2070785(+) GGTGCG/CATCTC 1 -- int12Minor allele frequency- C:0.00NA CSA 3
    rs1462780781,2
    C--2070812(+) TGCCGC/GCAGGG 1 -- int10--------
    rs2011806941,2
    --2070916(+) AGTAG-/CTGT  
            
    CTAAA
    1 -- int10--------
    rs1390293541,2
    C--2070989(+) CCCCTA/GGGACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for MOB3A (2071035 - 2096672 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MOB3A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MOB3A
    DNA2.0 Custom Variant and Variant Library Synthesis for MOB3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MOB3A gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with MOB3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Molecular characterization of human homologs of yeast MOB1. (PubMed id 19739119)1 Chow A.... Yang X. (Int. J. Cancer 2010)
    9. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (Mol. Syst. Biol. 2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 126308 HGNC: 29802 AceView: AP3D1andMOBKL2A Ensembl:ENSG00000172081 euGenes: HUgn126308
    ECgene: MOB3A H-InvDB: MOB3A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MOB3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MOB3A gene:
    Search GeneIP for patents involving MOB3A

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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