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Aliases for MOB3A Gene

Aliases for MOB3A Gene

  • MOB Kinase Activator 3A 2 3 5
  • Mps One Binder Kinase Activator-Like 2A 3 4
  • Mob1 Homolog 2A 3 4
  • MOB LAK 2 3
  • MOBKL2A 3 4
  • MOB-LAK 3 4
  • MOB1, Mps One Binder Kinase Activator-Like 2A (Yeast) 2
  • MOB1, Mps One Binder Kinase Activator-Like 2A 3
  • Moblak 3
  • MOB1C 3

External Ids for MOB3A Gene

Previous HGNC Symbols for MOB3A Gene

  • MOBKL2A

Summaries for MOB3A Gene

GeneCards Summary for MOB3A Gene

MOB3A (MOB Kinase Activator 3A) is a Protein Coding gene. An important paralog of this gene is MOB3B.

UniProtKB/Swiss-Prot for MOB3A Gene

  • May regulate the activity of kinases.

Gene Wiki entry for MOB3A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB3A Gene

Genomics for MOB3A Gene

Regulatory Elements for MOB3A Gene

Enhancers for MOB3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F002079 0.8 FANTOM5 ENCODE 11 +7.8 7821 18.9 MLX CREB3L1 DMAP1 YBX1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 SF3A2 CIRBP MKNK2 LINC01775 ENSG00000267063 ZNF77 C19orf24 BTBD2 SCAMP4 RPS15
GH19F002038 0.9 FANTOM5 ENCODE 9.6 +45.6 45648 24.2 MLX CREB3L1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MKNK2 ENSG00000261526 CIRBP SF3A2 SCAMP4 RPS15 ZNF77 LOC100288123 C19orf35 MOB3A
GH19F002072 0.8 Ensembl ENCODE 7 +22.4 22396 3.6 BCOR HDGF PKNOX1 CEBPB ELF1 ZBTB40 ZNF121 POLR2A TARDBP ZBTB33 IZUMO4 MOB3A LSM7 GC19P002080 GC19M002058
GH19F002064 0.8 FANTOM5 ENCODE 6.5 +30.6 30567 4.2 DRAP1 TFAP4 MXI1 ZNF792 SAP130 ZNF133 ARID4B ZNF384 ZNF48 RARA BTBD2 KLF16 MOB3A MKNK2 GC19M002058 GC19P002080
GH19F001772 0.4 ENCODE 6 +323.1 323090 1.4 SCRT1 GTF2F1 JUN MAX KLF17 NR3C1 EP300 HIC1 JUND SCRT2 ATP8B3 MIR1909 REXO1 UQCR11 TCF3 RNU6-1223P MOB3A LOC101928543 GC19M001748
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MOB3A on UCSC Golden Path with GeneCards custom track

Promoters for MOB3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001646014 873 3201 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for MOB3A Gene

Chromosome:
19
Start:
2,071,032 bp from pter
End:
2,096,673 bp from pter
Size:
25,642 bases
Orientation:
Minus strand

Genomic View for MOB3A Gene

Genes around MOB3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB3A Gene

Proteins for MOB3A Gene

  • Protein details for MOB3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BX8-MOB3A_HUMAN
    Recommended name:
    MOB kinase activator 3A
    Protein Accession:
    Q96BX8
    Secondary Accessions:
    • B3KTF1
    • O75249
    • Q8TF69

    Protein attributes for MOB3A Gene

    Size:
    217 amino acids
    Molecular mass:
    25464 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC27672.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB84554.1; Type=Miscellaneous discrepancy; Note=Chimera. There is an inclusion of DNA from another gene in position 141.; Evidence={ECO:0000305};

neXtProt entry for MOB3A Gene

Post-translational modifications for MOB3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MOB3A Gene

Domains & Families for MOB3A Gene

Gene Families for MOB3A Gene

Protein Domains for MOB3A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MOB3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BX8

UniProtKB/Swiss-Prot:

MOB3A_HUMAN :
  • Belongs to the MOB1/phocein family.
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB3A: view

Function for MOB3A Gene

Molecular function for MOB3A Gene

UniProtKB/Swiss-Prot Function:
May regulate the activity of kinases.

Gene Ontology (GO) - Molecular Function for MOB3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB3A: view
genes like me logo Genes that share phenotypes with MOB3A: view

Animal Model Products

miRNA for MOB3A Gene

miRTarBase miRNAs that target MOB3A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOB3A Gene

Localization for MOB3A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOB3A Gene COMPARTMENTS Subcellular localization image for MOB3A gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MOB3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
genes like me logo Genes that share ontologies with MOB3A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MOB3A Gene

Pathways & Interactions for MOB3A Gene

SuperPathways for MOB3A Gene

No Data Available

Interacting Proteins for MOB3A Gene

Gene Ontology (GO) - Biological Process for MOB3A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MOB3A Gene

Transcripts for MOB3A Gene

Unigene Clusters for MOB3A Gene

MOB kinase activator 3A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOB3A Gene

No ASD Table

Relevant External Links for MOB3A Gene

GeneLoc Exon Structure for
MOB3A
ECgene alternative splicing isoforms for
MOB3A

Expression for MOB3A Gene

mRNA expression in normal human tissues for MOB3A Gene

mRNA differential expression in normal tissues according to GTEx for MOB3A Gene

This gene is overexpressed in Whole Blood (x14.4).

Protein differential expression in normal tissues from HIPED for MOB3A Gene

This gene is overexpressed in Tlymphocyte (13.2), Lymph node (8.6), and Bone (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MOB3A Gene



Protein tissue co-expression partners for MOB3A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOB3A Gene:

MOB3A

SOURCE GeneReport for Unigene cluster for MOB3A Gene:

Hs.744938
genes like me logo Genes that share expression patterns with MOB3A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MOB3A Gene

Orthologs for MOB3A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOB3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOB3A 34 35
  • 99.23 (n)
dog
(Canis familiaris)
Mammalia MOB3A 34 35
  • 92.17 (n)
oppossum
(Monodelphis domestica)
Mammalia MOB3A 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MOB3A 34 35
  • 89.79 (n)
rat
(Rattus norvegicus)
Mammalia Mob3a 34
  • 88.02 (n)
mouse
(Mus musculus)
Mammalia Mob3a 34 16 35
  • 85.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MOB3A 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOB3A 35
  • 90 (a)
OneToOne
LOC100857182 34
  • 87.26 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mob3a 34
  • 75.15 (n)
zebrafish
(Danio rerio)
Actinopterygii mob3a 34 35
  • 80.19 (n)
wufc69e01 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3035 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007872 34
  • 65.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mob3 34 35
  • 63.38 (n)
worm
(Caenorhabditis elegans)
Secernentea T12B3.4 34 35
  • 60.81 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2077 35
  • 69 (a)
OneToMany
Species where no ortholog for MOB3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOB3A Gene

ENSEMBL:
Gene Tree for MOB3A (if available)
TreeFam:
Gene Tree for MOB3A (if available)

Paralogs for MOB3A Gene

Paralogs for MOB3A Gene

genes like me logo Genes that share paralogs with MOB3A: view

Variants for MOB3A Gene

Sequence variations from dbSNP and Humsavar for MOB3A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000393 -- 2,075,667(+) CCGAG(A/T)CACAA intron-variant
rs1004320 -- 2,082,679(-) GCAGC(A/G)CTGGC intron-variant
rs10403009 -- 2,079,300(+) ATGCC(A/G)GTCAC intron-variant
rs10403078 -- 2,081,524(+) caaag(G/T)ttgca intron-variant
rs10405969 -- 2,081,723(+) tacta(A/C)aaata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOB3A Gene

Variant ID Type Subtype PubMed ID
esv26236 CNV gain 19812545
esv2663238 CNV deletion 23128226
esv2672429 CNV deletion 23128226
esv3583203 CNV loss 25503493
esv3643418 CNV loss 21293372
esv3893156 CNV loss 25118596
nsv458325 CNV loss 19166990
nsv470107 CNV loss 18288195
nsv578380 CNV loss 21841781

Variation tolerance for MOB3A Gene

Residual Variation Intolerance Score: 53.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOB3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOB3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOB3A Gene

Disorders for MOB3A Gene

Relevant External Links for MOB3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOB3A

No disorders were found for MOB3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOB3A Gene

Publications for MOB3A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for MOB3A Gene

Sources for MOB3A Gene

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