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Aliases for MOB2 Gene

Aliases for MOB2 Gene

  • MOB Kinase Activator 2 2 3 5
  • Mps One Binder Kinase Activator-Like 2 3 4
  • HCCA2 3 4
  • MOB2 Mps One Binder Homolog (Yeast) 2
  • MOB2 Mps One Binder Homolog 3
  • Mob2 Homolog 4

External Ids for MOB2 Gene

Previous GeneCards Identifiers for MOB2 Gene

  • GC11M001278

Summaries for MOB2 Gene

GeneCards Summary for MOB2 Gene

MOB2 (MOB Kinase Activator 2) is a Protein Coding gene. An important paralog of this gene is MOB1A.

UniProtKB/Swiss-Prot for MOB2 Gene

  • Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB2 Gene

Genomics for MOB2 Gene

Regulatory Elements for MOB2 Gene

Enhancers for MOB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G001557 1.4 Ensembl ENCODE dbSUPER 19.9 -57.5 -57485 4.5 NFIB SIN3A KLF17 YY1 GLIS2 RCOR1 FOS EGR2 USF2 CEBPB KRTAP5-AS1 MOB2 KRTAP5-1 KRTAP5-2 GC11M001556 GC11M001565
GH11G001458 1.2 Ensembl ENCODE dbSUPER 20.2 +42.0 41959 2.1 CTCF MAZ KLF1 RAD21 HIC1 ZFHX2 ZNF316 EGR1 ZNF341 GLIS1 MOB2 KRTAP5-AS1 LOC105376514 PIR38157 GC11M001469
GH11G001530 0.9 ENCODE dbSUPER 21.2 -31.0 -31010 3.1 ZNF263 CTCF KLF1 MAZ SP3 ZNF687 MNT ZIC2 RAD21 GLIS2 MOB2 KRTAP5-AS1 TOLLIP-AS1 TOLLIP KRTAP5-5 GATD1 GC11P001533 GC11M001525
GH11G001545 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.2 -46.6 -46599 4.2 ATF1 SIN3A ETS1 GLIS2 KLF7 SP3 REST MEF2D MYNN GLIS1 KRTAP5-AS1 MOB2 TNNI2 TNNT3 DUSP8 BRSK2 KRTAP5-3 LOC101927562 GC11P001533
GH11G001382 1.5 FANTOM5 Ensembl ENCODE 10.7 +118.1 118057 1.7 PKNOX1 KLF17 GLIS2 EGR1 RELB CREM EGR2 SP3 ZEB2 ZNF398 TOLLIP-AS1 TOLLIP MOB2 DUSP8 BRSK2 IFITM10 GC11P001384 GC11M001373
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MOB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MOB2 Gene

Chromosome:
11
Start:
1,469,448 bp from pter
End:
1,501,247 bp from pter
Size:
31,800 bases
Orientation:
Minus strand

Genomic View for MOB2 Gene

Genes around MOB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB2 Gene

Proteins for MOB2 Gene

  • Protein details for MOB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70IA6-MOB2_HUMAN
    Recommended name:
    MOB kinase activator 2
    Protein Accession:
    Q70IA6
    Secondary Accessions:
    • B4DKP3
    • Q96M67

    Protein attributes for MOB2 Gene

    Size:
    237 amino acids
    Molecular mass:
    26927 Da
    Quaternary structure:
    • Binds STK38 and STK38L.

    Alternative splice isoforms for MOB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOB2 Gene

Post-translational modifications for MOB2 Gene

Other Protein References for MOB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MOB2 Gene

Domains & Families for MOB2 Gene

Gene Families for MOB2 Gene

Protein Domains for MOB2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MOB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q70IA6

UniProtKB/Swiss-Prot:

MOB2_HUMAN :
  • Belongs to the MOB1/phocein family.
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB2: view

Function for MOB2 Gene

Molecular function for MOB2 Gene

UniProtKB/Swiss-Prot Function:
Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.

Gene Ontology (GO) - Molecular Function for MOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24366813
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB2: view

Phenotypes for MOB2 Gene

genes like me logo Genes that share phenotypes with MOB2: view

Animal Models for MOB2 Gene

MGI Knock Outs for MOB2:
  • Mob2 tm1b(KOMP)Wtsi

Animal Model Products

miRNA for MOB2 Gene

miRTarBase miRNAs that target MOB2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOB2 Gene

Localization for MOB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOB2 Gene

Nucleus. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOB2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0044306 neuron projection terminus IEA --
genes like me logo Genes that share ontologies with MOB2: view

Pathways & Interactions for MOB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0010976 positive regulation of neuron projection development IEA --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with MOB2: view

No data available for Pathways by source and SIGNOR curated interactions for MOB2 Gene

Transcripts for MOB2 Gene

Unigene Clusters for MOB2 Gene

MOB kinase activator 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -
SP6:
SP7: -

Relevant External Links for MOB2 Gene

GeneLoc Exon Structure for
MOB2
ECgene alternative splicing isoforms for
MOB2

Expression for MOB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOB2 Gene

Protein differential expression in normal tissues from HIPED for MOB2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.5), Esophagus (6.8), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MOB2 Gene



Protein tissue co-expression partners for MOB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOB2 Gene:

MOB2

SOURCE GeneReport for Unigene cluster for MOB2 Gene:

Hs.370360

Evidence on tissue expression from TISSUES for MOB2 Gene

  • Nervous system(4.6)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with MOB2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOB2 Gene

Orthologs for MOB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOB2 34 35
  • 99 (n)
rat
(Rattus norvegicus)
Mammalia Mob2 34
  • 87.21 (n)
cow
(Bos Taurus)
Mammalia MOB2 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mob2 34 16 35
  • 86.93 (n)
dog
(Canis familiaris)
Mammalia MOB2 34 35
  • 85.34 (n)
oppossum
(Monodelphis domestica)
Mammalia MOB2 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOB2 35 34
  • 77.82 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MOB2 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mob2.1 34
  • 79.6 (n)
MGC76042 34
zebrafish
(Danio rerio)
Actinopterygii mob2a 35 34
  • 74.3 (n)
OneToMany
mob2b 35
  • 74 (a)
OneToMany
MOB2 (3 of 3) 35
  • 36 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010841 34
  • 57.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mob2 35
  • 16 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F38H4.10 35
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2588 34
Species where no ortholog for MOB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOB2 Gene

ENSEMBL:
Gene Tree for MOB2 (if available)
TreeFam:
Gene Tree for MOB2 (if available)

Paralogs for MOB2 Gene

Paralogs for MOB2 Gene

(7) SIMAP similar genes for MOB2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOB2: view

Variants for MOB2 Gene

Sequence variations from dbSNP and Humsavar for MOB2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000403535 -- 1,484,117(+) CAGGA(A/G)TGGGG intron-variant
rs1000447345 -- 1,470,606(+) GCCAC(C/T)CTCAG intron-variant, upstream-variant-2KB
rs1000487310 -- 1,485,687(+) CTGGC(G/T)GTGCC intron-variant
rs1000612841 -- 1,481,413(+) CAGCC(A/T)GGCCT intron-variant
rs1000676990 -- 1,475,570(+) GATTA(C/T)AGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOB2 Gene

Variant ID Type Subtype PubMed ID
dgv10n68 CNV loss 17160897
esv2669189 CNV deletion 23128226
esv2743878 CNV deletion 23290073
nsv951279 CNV deletion 24416366

Variation tolerance for MOB2 Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOB2 Gene

Disorders for MOB2 Gene

Relevant External Links for MOB2

Human Genome Epidemiology (HuGE) Navigator
MOB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOB2

No disorders were found for MOB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOB2 Gene

Publications for MOB2 Gene

  1. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. (PMID: 15067004) Devroe E. … Silver P.A. (J. Biol. Chem. 2004) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Gene expression profile in Alzheimer's brain screened by molecular indexing. (PMID: 11223154) Doyu M. … Kato K. (Brain Res. Mol. Brain Res. 2001) 2 3 64
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64

Products for MOB2 Gene

Sources for MOB2 Gene

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