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Aliases for MOB2 Gene

Aliases for MOB2 Gene

  • MOB Kinase Activator 2 2 3
  • Mps One Binder Kinase Activator-Like 2 3 4
  • HCCA2 3 4
  • MOB2 Mps One Binder Homolog (Yeast) 2
  • MOB2 Mps One Binder Homolog 3
  • Mob2 Homolog 4

External Ids for MOB2 Gene

Previous GeneCards Identifiers for MOB2 Gene

  • GC11M001278

Summaries for MOB2 Gene

GeneCards Summary for MOB2 Gene

MOB2 (MOB Kinase Activator 2) is a Protein Coding gene. An important paralog of this gene is MOB3A.

UniProtKB/Swiss-Prot for MOB2 Gene

  • Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB2 Gene

Genomics for MOB2 Gene

Genomic Location for MOB2 Gene

Chromosome:
11
Start:
1,469,448 bp from pter
End:
1,501,247 bp from pter
Size:
31,800 bases
Orientation:
Minus strand

Genomic View for MOB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MOB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB2 Gene

No data available for Regulatory Elements for MOB2 Gene

Proteins for MOB2 Gene

  • Protein details for MOB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70IA6-MOB2_HUMAN
    Recommended name:
    MOB kinase activator 2
    Protein Accession:
    Q70IA6
    Secondary Accessions:
    • B4DKP3
    • Q96M67

    Protein attributes for MOB2 Gene

    Size:
    237 amino acids
    Molecular mass:
    26927 Da
    Quaternary structure:
    • Binds STK38 and STK38L

    Alternative splice isoforms for MOB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOB2 Gene

Proteomics data for MOB2 Gene at MOPED

Post-translational modifications for MOB2 Gene

Other Protein References for MOB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MOB2 Gene

Domains & Families for MOB2 Gene

Gene Families for MOB2 Gene

Protein Domains for MOB2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MOB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q70IA6

UniProtKB/Swiss-Prot:

MOB2_HUMAN :
  • Belongs to the MOB1/phocein family.
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB2: view

Function for MOB2 Gene

Molecular function for MOB2 Gene

UniProtKB/Swiss-Prot Function:
Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.

Gene Ontology (GO) - Molecular Function for MOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB2: view

Phenotypes for MOB2 Gene

genes like me logo Genes that share phenotypes with MOB2: view

Animal Model Products

CRISPR Products

miRNA for MOB2 Gene

miRTarBase miRNAs that target MOB2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MOB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MOB2 Gene

Localization for MOB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOB2 Gene

Nucleus. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOB2 Gene COMPARTMENTS Subcellular localization image for MOB2 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0044306 neuron projection terminus IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MOB2: view

Pathways & Interactions for MOB2 Gene

SuperPathways for MOB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0010976 positive regulation of neuron projection development IEA --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with MOB2: view

No data available for Pathways by source and SIGNOR curated interactions for MOB2 Gene

Drugs & Compounds for MOB2 Gene

No Compound Related Data Available

Transcripts for MOB2 Gene

Unigene Clusters for MOB2 Gene

MOB kinase activator 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MOB2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -
SP6:
SP7: -

Relevant External Links for MOB2 Gene

GeneLoc Exon Structure for
MOB2
ECgene alternative splicing isoforms for
MOB2

Expression for MOB2 Gene

mRNA expression in normal human tissues for MOB2 Gene

Protein differential expression in normal tissues from HIPED for MOB2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.5), Esophagus (6.8), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MOB2 Gene



SOURCE GeneReport for Unigene cluster for MOB2 Gene Hs.370360

genes like me logo Genes that share expression patterns with MOB2: view

Protein tissue co-expression partners for MOB2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MOB2 Gene

Orthologs for MOB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOB2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MOB2 35
  • 85.34 (n)
  • 85.71 (a)
MOB2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mob2 35
  • 86.93 (n)
  • 91.38 (a)
Mob2 16
Mob2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MOB2 35
  • 99 (n)
  • 99.25 (a)
MOB2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mob2 35
  • 87.21 (n)
  • 91.38 (a)
cow
(Bos Taurus)
Mammalia MOB2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MOB2 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOB2 35
  • 77.82 (n)
  • 81.2 (a)
MOB2 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MOB2 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76042 35
mob2.1 35
  • 79.6 (n)
  • 82.65 (a)
zebrafish
(Danio rerio)
Actinopterygii mob2a 35
  • 74.3 (n)
  • 76.21 (a)
MOB2 (3 of 3) 36
  • 36 (a)
OneToMany
mob2a 36
  • 64 (a)
OneToMany
mob2b 36
  • 74 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010841 35
  • 57.92 (n)
  • 53.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mob2 36
  • 16 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F38H4.10 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2588 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for MOB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOB2 Gene

ENSEMBL:
Gene Tree for MOB2 (if available)
TreeFam:
Gene Tree for MOB2 (if available)

Paralogs for MOB2 Gene

Paralogs for MOB2 Gene

(7) SIMAP similar genes for MOB2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOB2: view

Variants for MOB2 Gene

Sequence variations from dbSNP and Humsavar for MOB2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs9440 -- 1,469,866(-) GTCTC(C/T)GTGCA utr-variant-3-prime
rs1104767 -- 1,486,382(-) TGCCC(C/T)CAGGA intron-variant
rs1105350 -- 1,483,785(+) CAGCA(C/T)GTAAC intron-variant
rs1105871 -- 1,487,913(+) GAGGA(C/T)GGCCC upstream-variant-2KB
rs1110206 -- 1,486,565(-) CCCGT(C/T)GCCCA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MOB2 Gene

Variant ID Type Subtype PubMed ID
esv2743878 CNV Deletion 23290073
esv2669189 CNV Deletion 23128226
dgv963n71 CNV Loss 21882294
dgv968n71 CNV Loss 21882294
dgv971n71 CNV Loss 21882294
dgv973n71 CNV Loss 21882294
nsv896691 CNV Loss 21882294
dgv10n68 CNV Loss 17160897
dgv974n71 CNV Loss 21882294
dgv976n71 CNV Loss 21882294
nsv896707 CNV Loss 21882294
nsv896708 CNV Loss 21882294
nsv896709 CNV Loss 21882294
esv2743938 CNV Deletion 23290073
esv2743939 CNV Deletion 23290073
esv25033 CNV Gain 19812545
esv1249924 CNV Deletion 17803354
esv2743940 CNV Deletion 23290073
nsv7640 CNV Insertion 18451855
esv2665572 CNV Deletion 23128226
esv989291 CNV Insertion 20482838
esv1440409 CNV Deletion 17803354
esv2743941 CNV Deletion 23290073
esv2743943 CNV Deletion 23290073
dgv977n71 CNV Loss 21882294
esv1374218 CNV Deletion 17803354
esv2743944 CNV Deletion 23290073
dgv978n71 CNV Loss 21882294
nsv7641 CNV Insertion 18451855
esv2743945 CNV Deletion 23290073
esv2743946 CNV Deletion 23290073
esv991273 CNV Deletion 20482838
nsv517817 CNV Loss 19592680
dgv979n71 CNV Loss 21882294
dgv980n71 CNV Loss 21882294
nsv467643 CNV Loss 19166990
dgv981n71 CNV Loss 21882294
nsv467644 CNV Loss 19166990
esv2743947 CNV Deletion 23290073
dgv982n71 CNV Loss 21882294
esv2743948 CNV Deletion 23290073
esv2743949 CNV Deletion 23290073
esv2506963 CNV Loss 19546169
esv2563178 CNV Deletion 19546169
dgv185e199 CNV Deletion 23128226
esv2743950 CNV Deletion 23290073
esv26436 CNV Loss 19812545
nsv896726 CNV Loss 21882294
nsv511489 CNV Loss 21212237
esv2743951 CNV Deletion 23290073
nsv820621 CNV Deletion 20802225
esv26626 CNV Loss 19812545
nsv512203 CNV Loss 21212237
esv2177310 CNV Deletion 18987734
esv4459 CNV Deletion 18987735
esv2743952 CNV Deletion 23290073
esv8209 CNV Loss 19470904
nsv38977 CNV Loss 16902084
esv1027347 CNV Deletion 17803354
nsv896727 CNV Gain 21882294
esv2743954 CNV Deletion 23290073
esv29845 CNV Loss 19812545
esv1927342 CNV Deletion 18987734
esv2743955 CNV Deletion 23290073
esv2743956 CNV Deletion 23290073
nsv896728 CNV Gain 21882294
esv7747 OTHER Inversion 19470904
nsv435977 OTHER Inversion 17901297
nsv832049 CNV Loss 17160897
esv2214914 CNV Deletion 18987734
esv24126 CNV Loss 19812545
esv2743957 CNV Deletion 23290073
esv2179135 CNV Deletion 18987734
nsv896729 CNV Loss 21882294
nsv896730 CNV Loss 21882294
esv2743958 CNV Deletion 23290073
esv1323796 CNV Deletion 17803354
esv2743959 CNV Deletion 23290073
esv2743960 CNV Deletion 23290073
nsv896731 CNV Loss 21882294
esv2743961 CNV Deletion 23290073
esv2743962 CNV Deletion 23290073
nsv896732 CNV Loss 21882294
esv2743963 CNV Deletion 23290073
esv2678678 CNV Deletion 23128226
nsv467645 CNV Gain 19166990
nsv896733 CNV Loss 21882294
esv2403037 CNV Deletion 18987734
nsv7642 CNV Insertion 18451855
nsv896734 CNV Loss 21882294
nsv896735 CNV Loss 21882294
nsv896736 CNV Loss 21882294
esv1293972 CNV Insertion 17803354

Variation tolerance for MOB2 Gene

Residual Variation Intolerance Score: 57.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOB2 Gene

HapMap Linkage Disequilibrium report
MOB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOB2 Gene

Disorders for MOB2 Gene

Relevant External Links for MOB2

Human Genome Epidemiology (HuGE) Navigator
MOB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOB2
genes like me logo Genes that share disorders with MOB2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOB2 Gene

Publications for MOB2 Gene

  1. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. (PMID: 15067004) Devroe E. … Silver P.A. (J. Biol. Chem. 2004) 2 23 67
  2. Gene expression profile in Alzheimer's brain screened by molecular indexing. (PMID: 11223154) Doyu M. … Kato K. (Brain Res. Mol. Brain Res. 2001) 2 67
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 67
  4. Regulation of DNA damage responses and cell cycle progression by hMOB2. (PMID: 25460043) Gomez V. … Hergovich A. (Cell. Signal. 2015) 67
  5. Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. (PMID: 24366813) Hauri S. … Gstaiger M. (Mol. Syst. Biol. 2013) 67

Products for MOB2 Gene

Sources for MOB2 Gene

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