MOB2 Gene
protein-coding GIFtS: 45
GCID: GC11M001490
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MOB kinase activator 2
| |
Aliases
for MOB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MOB Kinase Activator 21 2 | | HCCA21 2 3 5 | | Mob2 Homolog2 3 | | Mps One Binder Kinase Activator-Like 22 3 | | MOB2 Mps One Binder Homolog2 |
Export aliases for MOB2 gene to outside databasesPrevious GC identifer: GC11M001278 |
Summaries
for MOB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MOB2_HUMAN, Q70IA6Function: Stimulates the autophosphorylation and kinase activity of STK38 and STK38L
|
Genomic Views
for MOB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MOB2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MOB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOB2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5MOB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M001490: view genomic region
(about GC identifiers)
Start:
|
1,490,685 bp from pter |
End:
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1,522,477 bp from pter |
Size:
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31,793 bases |
Orientation:
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minus strand |
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Proteins
for MOB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MOB2_HUMAN, Q70IA6 (See
protein sequence)Recommended Name: MOB kinase activator 2 Size: 237 amino acids; 26927 Da
Subunit: Binds STK38 and STK38L
Subcellular location: Nucleus. Cytoplasm, perinuclear region
Secondary accessions: B4DKP3 Q96M67Alternative splicing: 3 isoforms: Q70IA6-1 Q70IA6-2 Q70IA6-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MOB2: NX_Q70IA6
Post-translational modifications:
Phosphorylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q70IA6
MOB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001165694.1 NP_443731.2
ENSEMBL proteins: ENSP00000328694
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MOB2 for ontologies About GeneDecksing
MOB2 Antibody Products:
Assay Products for MOB2: |
Protein
Domains /
Families
for MOB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MOB2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q70IA6ProtoNet protein and cluster: Q70IA6 1 Blocks protein family: IPB005301 Mob1/phocein family
UniProtKB/Swiss-Prot: MOB2_HUMAN, Q70IA6Similarity: Belongs to the MOB1/phocein family |
Function
for MOB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MOB2_HUMAN, Q70IA6Function: Stimulates the autophosphorylation and kinase activity of STK38 and STK38L
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MOB2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MOB2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for MOB2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOB2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- |
MOB2 for ontologies About GeneDecksing
|
Pathways & Interactions
for MOB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOB2
2 Interacting proteins for MOB2 (Q70IA63) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for MOB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MOB2
Search CenterWatch for drugs/clinical trials and news about MOB2
|
Transcripts
for MOB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MOB2 gene (2 alternative transcripts): NM_001172223.1 NM_053005.4 Unigene Cluster for MOB2: MOB kinase activator 2 Hs.370360 [show with all ESTs]Unigene Representative Sequence: BX5373736 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000531976(uc001lto.2 uc001ltp.1 uc001ltq.2) ENST00000329957(uc010qwz.2)
ENST00000526462 ENST00000526698 ENST00000529380 ENST00000529897
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MOB2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MOB2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MOB2 (NM_053005) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MOB2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOB2 |
Additional cDNA sequence: AB066564.1 AJ580639.1 AK057350.1 AK296658.1 AK300235.1 BC035317.1 BC047291.1 BC058934.1 BC067785.1 BX537373.1 8 DOTS entries: DT.113456 DT.40192510 DT.97844783 DT.95134020 DT.95134015 DT.75102016 DT.100028270 DT.95134018 24/181 AceView cDNA sequences (see all 181): AI380671 BM663806 CA946949 BQ694944 AI673640 BG055686 AA670391 CR607171 CD365072 BM015956 CR591411 BQ230053 CD108611 BU737994 CR592866 AA358209 BM993205 CR623644 BU740291 CA391393 BG340498 BM480305 CB140209 BM547106
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MOB2 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e |
|---|
|
| SP1: | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MOB2
|
Expression
for MOB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MOB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCAGTCCT
About this image
See MOB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MOB2
SOURCE GeneReport for Unigene cluster: Hs.370360
SABiosciences Custom PCR Arrays for MOB2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MOB2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MOB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOB2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB2 |
Orthologs
for MOB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MOB2 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for MOB2 (if available)
TreeFam Gene Tree for MOB2 (if available) |
Paralogs
for MOB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MOB2 gene
- MOB3C2 MOB3A2 MOB3B2 MOB1B2 MOB1A2
7 SIMAP similar genes for MOB2 using alignment to 1 protein entry: MOB2_HUMAN:MOB1B MOB4A MOBKL1A MOB1A MOB3A MOB3B
MOB3C
MOB2 for paralogs About GeneDecksing
|
Genomic Variants
for MOB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MOB2 (1490685 - 1522477 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 40 variations for MOB2
15/17 CNVs (see all 17): 71231 23404 4729 34933 34931 85595 75499 61090 65839 34929 75500 34927 34932 4728 34930
15/21 Indels (see all 21): 85591 85594 71232 11530 75494 75497 44850 71229 43089 24680 85590 75496 44848 44849 75498
2 Inversions: 29453 59689 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MOB2 |
|
Disorders
/ Diseases
for MOB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MOB2 for disorders About MalaCards
MOB2 for disorders About GeneDecksing
OMIM gene information: 611969
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MOB2 (2 documents)
Export disorders for MOB2 gene to outside databases
|
Publications
for MOB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MOB2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with MOB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. (PubMed id 15067004)1, 2, 3, 9 Devroe E.... Silver P.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Gene expression profile in Alzheimer's brain screened by molecular indexing. (PubMed id 11223154)1, 3 Doyu M.... Kato K. (2001)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide pol ymorphisms. (PubMed id 20889853)1 de Miguel-Yanes J.M....Meigs J.B. (2010)
- Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR ki nases. (PubMed id 20624913)1 Kohler R.S....Hergovich A. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
|
External Searches for MOB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MOB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MOB2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MOB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MOB2 gene:
Search GeneIP for patents involving MOB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MOB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MOB2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MOB2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MOB2 | | | OriGene Protein Over-expression Lysate for MOB2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MOB2 | | OriGene 3'-UTR Clone for MOB2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MOB2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MOB2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MOB2 | | OriGene Custom Protein Services for MOB2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MOB2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MOB2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOB2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOB2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MOB2 |
| |  |  |  |  | | | | |
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 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB2 |
|  |  |  | | | | ThermoFisher Antibody for MOB2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOB2 |
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