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Aliases for MOB2 Gene

Aliases for MOB2 Gene

  • MOB Kinase Activator 2 2 3 5
  • Mps One Binder Kinase Activator-Like 2 3 4
  • HCCA2 3 4
  • MOB2 Mps One Binder Homolog (Yeast) 2
  • MOB2 Mps One Binder Homolog 3
  • Mob2 Homolog 4

External Ids for MOB2 Gene

Previous GeneCards Identifiers for MOB2 Gene

  • GC11M001278

Summaries for MOB2 Gene

GeneCards Summary for MOB2 Gene

MOB2 (MOB Kinase Activator 2) is a Protein Coding gene. An important paralog of this gene is MOB1A.

UniProtKB/Swiss-Prot for MOB2 Gene

  • Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB2 Gene

Genomics for MOB2 Gene

Regulatory Elements for MOB2 Gene

Enhancers for MOB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MOB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MOB2 Gene

Chromosome:
11
Start:
1,469,448 bp from pter
End:
1,501,247 bp from pter
Size:
31,800 bases
Orientation:
Minus strand

Genomic View for MOB2 Gene

Genes around MOB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB2 Gene

Proteins for MOB2 Gene

  • Protein details for MOB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70IA6-MOB2_HUMAN
    Recommended name:
    MOB kinase activator 2
    Protein Accession:
    Q70IA6
    Secondary Accessions:
    • B4DKP3
    • Q96M67

    Protein attributes for MOB2 Gene

    Size:
    237 amino acids
    Molecular mass:
    26927 Da
    Quaternary structure:
    • Binds STK38 and STK38L.

    Alternative splice isoforms for MOB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOB2 Gene

Post-translational modifications for MOB2 Gene

Other Protein References for MOB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MOB2 Gene

Domains & Families for MOB2 Gene

Gene Families for MOB2 Gene

Protein Domains for MOB2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MOB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q70IA6

UniProtKB/Swiss-Prot:

MOB2_HUMAN :
  • Belongs to the MOB1/phocein family.
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB2: view

Function for MOB2 Gene

Molecular function for MOB2 Gene

UniProtKB/Swiss-Prot Function:
Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.

Gene Ontology (GO) - Molecular Function for MOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB2: view

Phenotypes for MOB2 Gene

genes like me logo Genes that share phenotypes with MOB2: view

Animal Models for MOB2 Gene

MGI Knock Outs for MOB2:
  • Mob2 tm1b(KOMP)Wtsi

Animal Model Products

CRISPR Products

miRNA for MOB2 Gene

miRTarBase miRNAs that target MOB2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOB2 Gene

Localization for MOB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOB2 Gene

Nucleus. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOB2 Gene COMPARTMENTS Subcellular localization image for MOB2 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IDA --
GO:0044306 neuron projection terminus IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MOB2: view

Pathways & Interactions for MOB2 Gene

SuperPathways for MOB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0010976 positive regulation of neuron projection development IEA --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with MOB2: view

No data available for Pathways by source and SIGNOR curated interactions for MOB2 Gene

Drugs & Compounds for MOB2 Gene

No Compound Related Data Available

Transcripts for MOB2 Gene

Unigene Clusters for MOB2 Gene

MOB kinase activator 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -
SP6:
SP7: -

Relevant External Links for MOB2 Gene

GeneLoc Exon Structure for
MOB2
ECgene alternative splicing isoforms for
MOB2

Expression for MOB2 Gene

mRNA expression in normal human tissues for MOB2 Gene

Protein differential expression in normal tissues from HIPED for MOB2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.5), Esophagus (6.8), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MOB2 Gene



Protein tissue co-expression partners for MOB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOB2 Gene:

MOB2

SOURCE GeneReport for Unigene cluster for MOB2 Gene:

Hs.370360
genes like me logo Genes that share expression patterns with MOB2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MOB2 Gene

Orthologs for MOB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOB2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MOB2 34
  • 85.34 (n)
  • 85.71 (a)
MOB2 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mob2 34
  • 86.93 (n)
  • 91.38 (a)
Mob2 16
Mob2 35
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MOB2 34
  • 99 (n)
  • 99.25 (a)
MOB2 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mob2 34
  • 87.21 (n)
  • 91.38 (a)
cow
(Bos Taurus)
Mammalia MOB2 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MOB2 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOB2 34
  • 77.82 (n)
  • 81.2 (a)
MOB2 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MOB2 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76042 34
mob2.1 34
  • 79.6 (n)
  • 82.65 (a)
zebrafish
(Danio rerio)
Actinopterygii mob2a 34
  • 74.3 (n)
  • 76.21 (a)
MOB2 (3 of 3) 35
  • 36 (a)
OneToMany
mob2a 35
  • 64 (a)
OneToMany
mob2b 35
  • 74 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010841 34
  • 57.92 (n)
  • 53.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mob2 35
  • 16 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F38H4.10 35
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 35
  • 24 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2588 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
Species where no ortholog for MOB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOB2 Gene

ENSEMBL:
Gene Tree for MOB2 (if available)
TreeFam:
Gene Tree for MOB2 (if available)

Paralogs for MOB2 Gene

Paralogs for MOB2 Gene

(7) SIMAP similar genes for MOB2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOB2: view

Variants for MOB2 Gene

Sequence variations from dbSNP and Humsavar for MOB2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1104767 -- 1,486,382(-) TGCCC(C/T)CAGGA intron-variant
rs1105350 -- 1,483,785(+) CAGCA(C/T)GTAAC intron-variant
rs1105871 -- 1,487,913(+) GAGGA(C/T)GGCCC upstream-variant-2KB
rs1110206 -- 1,486,565(-) CCCGT(C/T)GCCCA utr-variant-5-prime
rs1124566 -- 1,488,720(-) TGGAC(A/G)TTCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MOB2 Gene

Variant ID Type Subtype PubMed ID
dgv10n68 CNV loss 17160897
esv2669189 CNV deletion 23128226
esv2743878 CNV deletion 23290073
nsv951279 CNV deletion 24416366

Variation tolerance for MOB2 Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOB2 Gene

Disorders for MOB2 Gene

Relevant External Links for MOB2

Human Genome Epidemiology (HuGE) Navigator
MOB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOB2

No disorders were found for MOB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOB2 Gene

Publications for MOB2 Gene

  1. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. (PMID: 15067004) Devroe E. … Silver P.A. (J. Biol. Chem. 2004) 2 3 4 22 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Gene expression profile in Alzheimer's brain screened by molecular indexing. (PMID: 11223154) Doyu M. … Kato K. (Brain Res. Mol. Brain Res. 2001) 2 3 65
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 65

Products for MOB2 Gene

Sources for MOB2 Gene

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