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Aliases for MOB1B Gene

Aliases for MOB1B Gene

  • MOB Kinase Activator 1B 2 3 5
  • Mps One Binder Kinase Activator-Like 1A 3 4
  • Mob1 Homolog 1A 3 4
  • MOBKL1A 3 4
  • Mob1A 3 4
  • MOB4A 3 4
  • MOB1, Mps One Binder Kinase Activator-Like 1A (Yeast) 2
  • MOB1, Mps One Binder Kinase Activator-Like 1A 3
  • MOB1 Mps One Binder Homolog B (Yeast) 2
  • MOB1 Mps One Binder Homolog B 3
  • Mob4A Protein 2
  • MATS2 3
  • Mob1B 4

External Ids for MOB1B Gene

Previous HGNC Symbols for MOB1B Gene

  • MOBKL1A

Previous GeneCards Identifiers for MOB1B Gene

  • GC04P071769

Summaries for MOB1B Gene

Entrez Gene Summary for MOB1B Gene

  • The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for MOB1B Gene

MOB1B (MOB Kinase Activator 1B) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling and Hippo signaling pathway -multiple species. GO annotations related to this gene include kinase binding and kinase activator activity. An important paralog of this gene is MOB1A.

UniProtKB/Swiss-Prot for MOB1B Gene

  • Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Gene Wiki entry for MOB1B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB1B Gene

Genomics for MOB1B Gene

Regulatory Elements for MOB1B Gene

Enhancers for MOB1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G070901 1.5 FANTOM5 ENCODE 17.6 +1.1 1060 3.0 HNRNPUL1 PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 MOB1B DCK GRSF1 UTP3 JCHAIN
GH04G070926 0.9 Ensembl ENCODE 12.7 +24.3 24254 0.5 PKNOX1 ZNF146 ZNF280D MTA2 ZBED1 NR2F1 IKZF1 EED ETV6 IKZF2 MOB1B DCK
GH04G070923 0.9 Ensembl ENCODE 12.7 +22.2 22209 0.4 SOX13 SCRT1 ZNF362 JUNB FEZF1 ZNF384 ZNF324 ZNF121 PRDM6 SCRT2 MOB1B DCK
GH04G070992 1.7 FANTOM5 ENCODE dbSUPER 4.8 +93.3 93266 6.2 PKNOX1 MLX ARNT AGO1 ARID4B SIN3A FEZF1 ZBTB7B SLC30A9 ZNF766 DCK RUFY3 MOB1B JCHAIN GC04M071034
GH04G071186 1.3 Ensembl ENCODE dbSUPER 5.1 +286.1 286113 3.9 ARNT ZNF2 RAD21 YY1 GLIS2 ZNF366 ZSCAN5C FOS PRDM6 ZNF341 MOB1B SLC4A4 ENSG00000249170
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MOB1B on UCSC Golden Path with GeneCards custom track

Promoters for MOB1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000169031 826 2401 HNRNPUL1 PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1

Genomic Location for MOB1B Gene

Chromosome:
4
Start:
70,901,974 bp from pter
End:
71,022,449 bp from pter
Size:
120,476 bases
Orientation:
Plus strand

Genomic View for MOB1B Gene

Genes around MOB1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB1B Gene

Proteins for MOB1B Gene

  • Protein details for MOB1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L9L4-MOB1B_HUMAN
    Recommended name:
    MOB kinase activator 1B
    Protein Accession:
    Q7L9L4
    Secondary Accessions:
    • B2R8U6
    • B4DRY3
    • Q8IY23

    Protein attributes for MOB1B Gene

    Size:
    216 amino acids
    Molecular mass:
    25091 Da
    Quaternary structure:
    • Binds STK38L. Interacts with LATS1 and LATS2.

    Alternative splice isoforms for MOB1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOB1B Gene

Post-translational modifications for MOB1B Gene

  • Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MOB1B Gene

No data available for DME Specific Peptides for MOB1B Gene

Domains & Families for MOB1B Gene

Gene Families for MOB1B Gene

Protein Domains for MOB1B Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7L9L4

UniProtKB/Swiss-Prot:

MOB1B_HUMAN :
  • Belongs to the MOB1/phocein family.
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB1B: view

Function for MOB1B Gene

Molecular function for MOB1B Gene

UniProtKB/Swiss-Prot Function:
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Gene Ontology (GO) - Molecular Function for MOB1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19739119
GO:0019209 kinase activator activity IDA 15197186
GO:0019900 kinase binding IPI 15197186
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB1B: view
genes like me logo Genes that share phenotypes with MOB1B: view

Animal Model Products

CRISPR Products

miRNA for MOB1B Gene

miRTarBase miRNAs that target MOB1B

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MOB1B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOB1B Gene

Localization for MOB1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOB1B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOB1B gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MOB1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 15067004
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IDA 15067004
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with MOB1B: view

Pathways & Interactions for MOB1B Gene

genes like me logo Genes that share pathways with MOB1B: view

Pathways by source for MOB1B Gene

2 Cell Signaling Technology pathways for MOB1B Gene
2 Reactome pathways for MOB1B Gene

SIGNOR curated interactions for MOB1B Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MOB1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031952 regulation of protein autophosphorylation IDA 15197186
GO:0035329 hippo signaling TAS --
GO:0042327 positive regulation of phosphorylation IEA --
genes like me logo Genes that share ontologies with MOB1B: view

Drugs & Compounds for MOB1B Gene

No Compound Related Data Available

Transcripts for MOB1B Gene

Unigene Clusters for MOB1B Gene

MOB kinase activator 1B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MOB1B

Alternative Splicing Database (ASD) splice patterns (SP) for MOB1B Gene

No ASD Table

Relevant External Links for MOB1B Gene

GeneLoc Exon Structure for
MOB1B
ECgene alternative splicing isoforms for
MOB1B

Expression for MOB1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOB1B Gene

Protein differential expression in normal tissues from HIPED for MOB1B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.5), Monocytes (12.1), Tlymphocyte (12.1), and Blymphocyte (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MOB1B Gene



Protein tissue co-expression partners for MOB1B Gene

NURSA nuclear receptor signaling pathways regulating expression of MOB1B Gene:

MOB1B

SOURCE GeneReport for Unigene cluster for MOB1B Gene:

Hs.691454

mRNA Expression by UniProt/SwissProt for MOB1B Gene:

Q7L9L4-MOB1B_HUMAN
Tissue specificity: Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.

Evidence on tissue expression from TISSUES for MOB1B Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with MOB1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOB1B Gene

Orthologs for MOB1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOB1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOB1B 35
  • 100 (a)
OneToOne
MOBKL1A 34
  • 99.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MOB1B 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOB1B 34 35
  • 95.02 (n)
cow
(Bos Taurus)
Mammalia MOB1B 34 35
  • 94.79 (n)
oppossum
(Monodelphis domestica)
Mammalia MOB1B 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mob1b 34 16 35
  • 91.63 (n)
rat
(Rattus norvegicus)
Mammalia Mob1b 34
  • 91.47 (n)
chicken
(Gallus gallus)
Aves MOB1B 35
  • 97 (a)
OneToOne
MOBKL1A 34
  • 87.2 (n)
lizard
(Anolis carolinensis)
Reptilia MOB1B 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mob1b 34
  • 81.52 (n)
zebrafish
(Danio rerio)
Actinopterygii mob1ba 34 35
  • 79.62 (n)
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002066 34
  • 71.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta mats 34 35
  • 70.79 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 35
  • 34 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G45550 34
  • 64.9 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3019 34
rice
(Oryza sativa)
Liliopsida Os03g0577200 34
  • 64.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 79 (a)
OneToMany
Species where no ortholog for MOB1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOB1B Gene

ENSEMBL:
Gene Tree for MOB1B (if available)
TreeFam:
Gene Tree for MOB1B (if available)

Paralogs for MOB1B Gene

Paralogs for MOB1B Gene

(8) SIMAP similar genes for MOB1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MOB1B: view

Variants for MOB1B Gene

Sequence variations from dbSNP and Humsavar for MOB1B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000074886 -- 70,935,347(+) CCATC(C/T)GAAGA intron-variant
rs1000087094 -- 70,956,083(+) ATTTG(A/G)TGTTT intron-variant
rs1000096731 -- 70,930,869(+) GGGGA(A/G)CATTG intron-variant
rs1000125119 -- 70,962,757(+) ATTTT(A/G/T)GGAGG intron-variant
rs1000151489 -- 70,971,334(+) ATCTC(A/G)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MOB1B Gene

Variant ID Type Subtype PubMed ID
esv2727796 CNV deletion 23290073
esv3600942 CNV loss 21293372
esv3600943 CNV loss 21293372
nsv1012495 CNV gain 25217958
nsv1109615 CNV deletion 24896259
nsv1136873 CNV deletion 24896259
nsv594651 CNV loss 21841781
nsv594652 CNV loss 21841781
nsv829966 CNV loss 17160897

Variation tolerance for MOB1B Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOB1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOB1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOB1B Gene

Disorders for MOB1B Gene

Relevant External Links for MOB1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOB1B

No disorders were found for MOB1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOB1B Gene

Publications for MOB1B Gene

  1. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. (PMID: 15067004) Devroe E. … Silver P.A. (J. Biol. Chem. 2004) 2 3 4 64
  2. Molecular characterization of human homologs of yeast MOB1. (PMID: 19739119) Chow A. … Yang X. (Int. J. Cancer 2010) 3 4 64
  3. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. (PMID: 18328708) Praskova M. … Avruch J. (Curr. Biol. 2008) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MOB1B Gene

  • Addgene plasmids for MOB1B

Sources for MOB1B Gene

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