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Aliases for MOB1B Gene

Aliases for MOB1B Gene

  • MOB Kinase Activator 1B 2 3
  • Mps One Binder Kinase Activator-Like 1A 3 4
  • Mob1 Homolog 1A 3 4
  • MOBKL1A 3 4
  • Mob1A 3 4
  • MOB4A 3 4
  • MOB1, Mps One Binder Kinase Activator-Like 1A (Yeast) 2
  • MOB1, Mps One Binder Kinase Activator-Like 1A 3
  • MOB1 Mps One Binder Homolog B (Yeast) 2
  • MOB1 Mps One Binder Homolog B 3
  • Mob4A Protein 2
  • MATS2 3
  • Mob1B 4

External Ids for MOB1B Gene

Previous HGNC Symbols for MOB1B Gene

  • MOBKL1A

Previous GeneCards Identifiers for MOB1B Gene

  • GC04P071769

Summaries for MOB1B Gene

Entrez Gene Summary for MOB1B Gene

  • The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for MOB1B Gene

MOB1B (MOB Kinase Activator 1B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Hippo signaling pathway. GO annotations related to this gene include kinase binding and kinase activator activity. An important paralog of this gene is MOB3A.

UniProtKB/Swiss-Prot for MOB1B Gene

  • Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Gene Wiki entry for MOB1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB1B Gene

Genomics for MOB1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MOB1B Gene

Start:
70,902,326 bp from pter
End:
71,022,449 bp from pter
Size:
120,124 bases
Orientation:
Plus strand

Genomic View for MOB1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MOB1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB1B Gene

No data available for Regulatory Elements for MOB1B Gene

Proteins for MOB1B Gene

  • Protein details for MOB1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L9L4-MOB1B_HUMAN
    Recommended name:
    MOB kinase activator 1B
    Protein Accession:
    Q7L9L4
    Secondary Accessions:
    • B2R8U6
    • B4DRY3
    • Q8IY23

    Protein attributes for MOB1B Gene

    Size:
    216 amino acids
    Molecular mass:
    25091 Da
    Quaternary structure:
    • Binds STK38L. Interacts with LATS1 and LATS2.

    Alternative splice isoforms for MOB1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOB1B Gene

Proteomics data for MOB1B Gene at MOPED

Post-translational modifications for MOB1B Gene

  • Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.
  • Ubiquitination at Lys17, Lys30, Lys104, and Lys142
  • Modification sites at PhosphoSitePlus

Other Protein References for MOB1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MOB1B (MOB1B)

No data available for DME Specific Peptides for MOB1B Gene

Domains for MOB1B Gene

Gene Families for MOB1B Gene

HGNC:
  • MOB :MOB kinase activators

Protein Domains for MOB1B Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7L9L4

UniProtKB/Swiss-Prot:

MOB1B_HUMAN :
  • Q7L9L4
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB1B: view

No data available for Suggested Antigen Peptide Sequences for MOB1B Gene

Function for MOB1B Gene

Molecular function for MOB1B Gene

UniProtKB/Swiss-Prot Function: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Gene Ontology (GO) - Molecular Function for MOB1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19739119
GO:0019209 kinase activator activity IDA 15197186
GO:0019900 kinase binding IPI 15197186
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB1B: view
genes like me logo Genes that share phenotypes with MOB1B: view

Animal Model Products

CRISPR Products

miRNA for MOB1B Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MOB1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MOB1B Gene

Localization for MOB1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOB1B Gene

Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for MOB1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15067004
GO:0005737 cytoplasm IDA 15067004
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with MOB1B: view

No data available for Subcellular locations from COMPARTMENTS for MOB1B Gene

Pathways for MOB1B Gene

genes like me logo Genes that share pathways with MOB1B: view

Pathways by source for MOB1B Gene

1 Cell Signaling Technology pathway for MOB1B Gene
2 Reactome pathways for MOB1B Gene
1 KEGG pathway for MOB1B Gene

Gene Ontology (GO) - Biological Process for MOB1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035329 hippo signaling TAS --
GO:0042327 positive regulation of phosphorylation IDA 15197186
GO:0046777 protein autophosphorylation IDA 15197186
genes like me logo Genes that share ontologies with MOB1B: view

Transcripts for MOB1B Gene

Unigene Clusters for MOB1B Gene

MOB kinase activator 1B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MOB1B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOB1B Gene

No ASD Table

Relevant External Links for MOB1B Gene

GeneLoc Exon Structure for
MOB1B
ECgene alternative splicing isoforms for
MOB1B

Expression for MOB1B Gene

mRNA expression in normal human tissues for MOB1B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MOB1B Gene

SOURCE GeneReport for Unigene cluster for MOB1B Gene Hs.691454

mRNA Expression by UniProt/SwissProt for MOB1B Gene

Q7L9L4-MOB1B_HUMAN
Tissue specificity: Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.
genes like me logo Genes that share expressions with MOB1B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MOB1B Gene

Orthologs for MOB1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOB1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOB1B 36
  • 100 (a)
OneToOne
MOBKL1A 35
  • 99.85 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia MOB1B 35
  • 94.79 (n)
  • 100 (a)
MOB1B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOB1B 35
  • 95.02 (n)
  • 99.1 (a)
MOB1B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mob1b 35
  • 91.63 (n)
  • 100 (a)
Mob1b 16
Mob1b 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MOB1B 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MOB1B 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mob1b 35
  • 91.47 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves MOB1B 36
  • 97 (a)
OneToOne
MOBKL1A 35
  • 87.2 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia MOB1B 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mob1b 35
  • 81.52 (n)
  • 98.1 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
mob1ba 35
  • 79.62 (n)
  • 97.63 (a)
mob1ba 36
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002066 35
  • 71.15 (n)
  • 86.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta mats 35
  • 70.79 (n)
  • 88.57 (a)
mats 36
  • 85 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 36
  • 34 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3019 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G45550 35
  • 64.9 (n)
  • 68.6 (a)
rice
(Oryza sativa)
Liliopsida Os03g0577200 35
  • 64.55 (n)
  • 68.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
OneToMany
Species with no ortholog for MOB1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOB1B Gene

ENSEMBL:
Gene Tree for MOB1B (if available)
TreeFam:
Gene Tree for MOB1B (if available)

Paralogs for MOB1B Gene

Paralogs for MOB1B Gene

Selected SIMAP similar genes for MOB1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MOB1B: view

Variants for MOB1B Gene

Sequence variations from dbSNP and Humsavar for MOB1B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1385985 -- 70,986,693(-) TTCCA(C/T)GGTAA utr-variant-3-prime
rs1817629 -- 70,985,786(-) TCCCA(G/T)CACTT utr-variant-3-prime
rs1871048 -- 70,902,362(-) GCAGG(C/G)GGAGG utr-variant-5-prime
rs1871049 -- 70,902,189(-) TGGGG(A/T)CTCTC upstream-variant-2KB
rs2035187 -- 70,947,088(-) ACTGG(A/C)TAAGA intron-variant

Relevant External Links for MOB1B Gene

HapMap Linkage Disequilibrium report
MOB1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MOB1B Gene

Disorders for MOB1B Gene

No disorders were found for MOB1B Gene.

No data available for UniProtKB/Swiss-Prot for MOB1B Gene

Publications for MOB1B Gene

  1. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. (PMID: 15067004) Devroe E. … Silver P.A. (J. Biol. Chem. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. (PMID: 18328708) Praskova M. … Avruch J. (Curr. Biol. 2008) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Molecular characterization of human homologs of yeast MOB1. (PMID: 19739119) Chow A. … Yang X. (Int. J. Cancer 2010) 3 4

Products for MOB1B Gene

  • Addgene plasmids for MOB1B

Sources for MOB1B Gene

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