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Aliases for MOB1A Gene

Aliases for MOB1A Gene

  • MOB Kinase Activator 1A 2 3
  • Mps One Binder Kinase Activator-Like 1B 3 4
  • Mob1 Homolog 1B 3 4
  • Mob1 Alpha 3 4
  • MOBKL1B 3 4
  • C2orf6 3 4
  • MOBK1B 3 4
  • Mob4B 3 4
  • MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast) 2
  • MOB1, Mps One Binder Kinase Activator-Like 1B 3
  • MOB1 Mps One Binder Homolog A (Yeast) 2
  • Chromosome 2 Open Reading Frame 6 2
  • MOB1 Mps One Binder Homolog A 3
  • MATS1 3
  • Mob1A 4
  • MOB1 3

External Ids for MOB1A Gene

Previous HGNC Symbols for MOB1A Gene

  • C2orf6
  • MOBK1B
  • MOBKL1B

Previous GeneCards Identifiers for MOB1A Gene

  • GC02M074382

Summaries for MOB1A Gene

GeneCards Summary for MOB1A Gene

MOB1A (MOB Kinase Activator 1A) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Hippo signaling pathway. An important paralog of this gene is MOB3A.

UniProtKB/Swiss-Prot for MOB1A Gene

  • Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

Gene Wiki entry for MOB1A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB1A Gene

Genomics for MOB1A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MOB1A Gene

Start:
74,152,528 bp from pter
End:
74,178,898 bp from pter
Size:
26,371 bases
Orientation:
Minus strand

Genomic View for MOB1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MOB1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB1A Gene

No data available for Regulatory Elements for MOB1A Gene

Proteins for MOB1A Gene

  • Protein details for MOB1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8S9-MOB1A_HUMAN
    Recommended name:
    MOB kinase activator 1A
    Protein Accession:
    Q9H8S9
    Secondary Accessions:
    • Q53S34
    • Q9H3T5
    • Q9HAI0
    • Q9NVE2

    Protein attributes for MOB1A Gene

    Size:
    216 amino acids
    Molecular mass:
    25080 Da
    Quaternary structure:
    • Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2.

    Three dimensional structures from OCA and Proteopedia for MOB1A Gene

    Alternative splice isoforms for MOB1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOB1A Gene

Proteomics data for MOB1A Gene at MOPED

Post-translational modifications for MOB1A Gene

  • Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.
  • Ubiquitination at Lys17, Lys30, Lys104, and Lys142
  • Modification sites at PhosphoSitePlus

Other Protein References for MOB1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MOB1A (MOB1A)

No data available for DME Specific Peptides for MOB1A Gene

Domains for MOB1A Gene

Gene Families for MOB1A Gene

HGNC:
  • MOB :MOB kinase activators

Protein Domains for MOB1A Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H8S9

UniProtKB/Swiss-Prot:

MOB1A_HUMAN :
  • Q9H8S9
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB1A: view

No data available for Suggested Antigen Peptide Sequences for MOB1A Gene

Function for MOB1A Gene

Molecular function for MOB1A Gene

UniProtKB/Swiss-Prot Function: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

Gene Ontology (GO) - Molecular Function for MOB1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15197186
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB1A: view
genes like me logo Genes that share phenotypes with MOB1A: view

Animal Model Products

CRISPR Products

miRNA for MOB1A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MOB1A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MOB1A Gene

Localization for MOB1A Gene

Gene Ontology (GO) - Cellular Components for MOB1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with MOB1A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for MOB1A Gene

Pathways for MOB1A Gene

genes like me logo Genes that share pathways with MOB1A: view

Pathways by source for MOB1A Gene

1 Cell Signaling Technology pathway for MOB1A Gene
2 Reactome pathways for MOB1A Gene
1 KEGG pathway for MOB1A Gene

Gene Ontology (GO) - Biological Process for MOB1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035329 hippo signaling TAS --
genes like me logo Genes that share ontologies with MOB1A: view

Transcripts for MOB1A Gene

Unigene Clusters for MOB1A Gene

MOB kinase activator 1A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MOB1A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOB1A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - - - - -
SP8: -

Relevant External Links for MOB1A Gene

GeneLoc Exon Structure for
MOB1A
ECgene alternative splicing isoforms for
MOB1A

Expression for MOB1A Gene

mRNA expression in normal human tissues for MOB1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOB1A Gene

This gene is overexpressed in Whole Blood (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MOB1A Gene

SOURCE GeneReport for Unigene cluster for MOB1A Gene Hs.602092

mRNA Expression by UniProt/SwissProt for MOB1A Gene

Q9H8S9-MOB1A_HUMAN
Tissue specificity: Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver.
genes like me logo Genes that share expressions with MOB1A: view

In Situ Assay Products

Orthologs for MOB1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOB1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOBKL1B 35
  • 99.85 (n)
  • 100 (a)
MOBKL1B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MOB1A 35
  • 95.68 (n)
  • 100 (a)
MOBKL1B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOB1A 35
  • 96.91 (n)
  • 100 (a)
MOB1A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mob1a 35
  • 93.06 (n)
  • 100 (a)
Mob1a 16
Mob1a 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Mob1a 35
  • 92.75 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves LOC429657 35
  • 82.87 (n)
  • 98.61 (a)
MOB1A 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MOB1 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mob1a 35
  • 81.79 (n)
  • 98.15 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100331697 35
  • 79.63 (n)
  • 95.83 (a)
mob1a 36
  • 96 (a)
OneToOne
wufv69d04 35
fruit fly
(Drosophila melanogaster)
Insecta mats 36
  • 85 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL236W 35
  • 55.12 (n)
  • 56.42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 35
  • 55.08 (n)
  • 51.9 (a)
MOB1 36
  • 36 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03795g 35
  • 57.37 (n)
  • 56.32 (a)
rice
(Oryza sativa)
Liliopsida Os10g0396300 35
  • 65.09 (n)
  • 65.88 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01605 35
  • 53.12 (n)
  • 50 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mob1 35
  • 59.94 (n)
  • 57.69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 81 (a)
OneToMany
Species with no ortholog for MOB1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOB1A Gene

ENSEMBL:
Gene Tree for MOB1A (if available)
TreeFam:
Gene Tree for MOB1A (if available)

Paralogs for MOB1A Gene

Paralogs for MOB1A Gene

Selected SIMAP similar genes for MOB1A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MOB1A Gene

genes like me logo Genes that share paralogs with MOB1A: view

Variants for MOB1A Gene

Sequence variations from dbSNP and Humsavar for MOB1A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs828851 -- 74,158,015(-) tacta(A/G)aaatg intron-variant
rs828852 -- 74,156,784(-) GCCTA(C/T)TTTAA intron-variant
rs828891 -- 74,162,821(+) AAGGA(G/T)TGATT intron-variant
rs828892 -- 74,163,468(+) ctcat(C/T)tctac intron-variant
rs828893 -- 74,164,431(+) gagaa(C/T)tgctt intron-variant

Relevant External Links for MOB1A Gene

HapMap Linkage Disequilibrium report
MOB1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MOB1A Gene

Disorders for MOB1A Gene

No disorders were found for MOB1A Gene.

No data available for UniProtKB/Swiss-Prot for MOB1A Gene

Publications for MOB1A Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  2. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  3. Crystal structure of a human Mob1 protein: toward understanding Mob- regulated cell cycle pathways. (PMID: 12962634) Stavridi E.S. … Luca F.C. (Structure 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. (PMID: 15197186) Bichsel S.J. … Hemmings B.A. (J. Biol. Chem. 2004) 3 4

Products for MOB1A Gene

  • Addgene plasmids for MOB1A

Sources for MOB1A Gene

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