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MOB1A Gene

protein-coding   GIFtS: 52
GCID: GC02M074382

MOB Kinase Activator 1A

(Previous names: chromosome 2 open reading frame 6, MOB1, Mps One Binder...)
(Previous symbols: C2orf6, MOBK1B, MOBKL1B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
MOB Kinase Activator 1A1 2     MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast)1
C2orf61 2 3     MATS12
MOBK1B1 2 3     MOB12
MOBKL1B1 2 3     Mob4B2
Mob1 Alpha2 3     MOB1 Mps One Binder Homolog A2
Mob1 Homolog 1B2 3     MOB1, Mps One Binder Kinase Activator-Like 1B2
Mps One Binder Kinase Activator-Like 1B2 3     MOB4B3
Chromosome 2 Open Reading Frame 61     Mob1A3
MOB1 Mps One Binder Homolog A (Yeast)1     

External Ids:    HGNC: 160151   Entrez Gene: 552332   Ensembl: ENSG000001149787   OMIM: 6092815   UniProtKB: Q9H8S93   
ORGUL members:         

Export aliases for MOB1A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MOB1A Gene:
MOB1A (MOB kinase activator 1A) is a protein-coding gene. Diseases associated with MOB1A include hepatitis c virus, and hepatitis c. An important paralog of this gene is MOB3C.

UniProtKB/Swiss-Prot: MOB1A_HUMAN, Q9H8S9
Function: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and
tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a
kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and
activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1
oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to
regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase
activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38

Gene Wiki entry for MOB1A (MOBKL1B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MOB1A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOB1A promoter sequence
   Search Chromatin IP Primers for MOB1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MOB1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.1

MOB1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOB1A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M074382:  view genomic region     (about GC identifiers)

Start:
74,379,655 bp from pter      End:
74,406,025 bp from pter
Size:
26,371 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MOB1A_HUMAN, Q9H8S9 (See protein sequence)
Recommended Name: MOB kinase activator 1A  
Size: 216 amino acids; 25080 Da
Subunit: Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and
STK3/MST2
2 PDB 3D structures from and Proteopedia for MOB1A:
1PI1 (3D)        4JIZ (3D)    
Secondary accessions: Q53S34 Q9H3T5 Q9HAI0 Q9NVE2
Alternative splicing: 2 isoforms:  Q9H8S9-1   Q9H8S9-2   (May be due to an intron retention)

Explore the universe of human proteins at neXtProt for MOB1A: NX_Q9H8S9

Explore proteomics data for MOB1A at MOPED

Post-translational modifications: 

  • Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS11
  • Ubiquitination2 at Lys17, Lys30, Lys104, Lys142
  • Modification sites at PhosphoSitePlus

  • See MOB1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060691.2  
    ENSEMBL proteins: 
     ENSP00000379364   ENSP00000386782  
    Reactome Protein details: Q9H8S9

    MOB1A Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MOB: MOB kinase activators

    1 InterPro protein domain:
     IPR005301 Mob1_phocein

    Graphical View of Domain Structure for InterPro Entry Q9H8S9

    ProtoNet protein and cluster: Q9H8S9

    1 Blocks protein domain: IPB005301 Mob1/phocein family

    UniProtKB/Swiss-Prot: MOB1A_HUMAN, Q9H8S9
    Similarity: Belongs to the MOB1/phocein family


    MOB1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOB1A_HUMAN, Q9H8S9
    Function: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and
    tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a
    kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and
    activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1
    oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to
    regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase
    activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15197186
    GO:0046872metal ion binding IEA--
         
    MOB1A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MOB1A:
     Increased gamma-H2AX phosphory 

         13 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mob1a):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  hearing/vestibular/ear  integument  limbs/digits/tail  mortality/aging 
     nervous system  skeleton  tumorigenesis 

    MOB1A for phenotypes           About GeneDecksing

    Animal Models:
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    hsa-mir-128-3p (MIRT021885), hsa-mir-93-5p (MIRT048766), hsa-mir-181a-5p (MIRT025110), hsa-let-7b-5p (MIRT032205)

    Block miRNA regulation of human, mouse, rat MOB1A using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidMOB1A 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA--

    MOB1A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MOB1A About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signal Transduction0.58
    2Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    3Signaling by Hippo
    Signaling by Hippo
    4Hippo signaling pathway
    Hippo signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MOB1A
        Wnt / Hedgehog / Notch

    1 Reactome Pathway for MOB1A
        Signaling by Hippo


    1 Kegg Pathway  (Kegg details for MOB1A):
        Hippo signaling pathway


    MOB1A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MOB1A
    Interactions:

        Search GeneGlobe Interaction Network for MOB1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MOB1A (Q9H8S91, 2, 3 ENSP000003793644) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-68190 I2D: score=5 STRING: ENSP00000311695
    STK38Q152081, 3, ENSP000002298124EBI-748229,EBI-458376 I2D: score=2 STRING: ENSP00000229812
    LATS1O958351, 3, ENSP000002533394EBI-748229,EBI-444209 I2D: score=1 STRING: ENSP00000253339
    STK38LQ9Y2H11, 3, ENSP000003736844EBI-748229,EBI-991501 I2D: score=8 STRING: ENSP00000373684
    LATS2Q9NRM71, 3, ENSP000003720354EBI-748229,EBI-3506895 I2D: score=1 STRING: ENSP00000372035
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035329hippo signaling TAS--

    MOB1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MOB1A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MOB1A gene: 
    NM_018221.3  

    Unigene Cluster for MOB1A:

    MOB kinase activator 1A
    Hs.602092  [show with all ESTs]
    Unigene Representative Sequence: AK123865
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396049(uc002skh.4) ENST00000497054 ENST00000495286 ENST00000463975(uc002ski.2)
    ENST00000488006 ENST00000494600 ENST00000409969
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MOB1A
      QuantiFast Probe-based Assays in human, mouse, rat MOB1A

    Additional mRNA sequence: 

    AB016839.1 AJ577474.1 AK001650.1 AK021657.1 AK023321.1 AK123865.1 AL122062.1 BC003398.1 

    18 DOTS entries:

    DT.75147897  DT.95266547  DT.91647641  DT.120938020  DT.100655804  DT.100655806  DT.424949  DT.92452595 
    DT.120937983  DT.91665813  DT.95266540  DT.87015892  DT.92452592  DT.92452593  DT.95266554  DT.99953352 
    DT.100655803  DT.87005796 

    Selected AceView cDNA sequences (see all 461):

    BU624946 BM454591 BM976529 AI806745 BG771348 BC003398 AA492533 Z44113 
    AA825917 CK903995 BU618595 BU623780 CA748530 AA923504 BU152863 AI673292 
    AI655298 AI434784 AL044116 AA604351 BQ773872 BM975460 AW262789 BG257976 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MOB1A (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b
    SP1:                    -     -     -                                         -                                 
    SP2:                    -     -     -                                         -                                 
    SP3:                    -     -     -                                         -     -     -     -               
    SP4:                                -                                         -                                 
    SP5:                    -     -     -                                                                           


    ECgene alternative splicing isoforms for MOB1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MOB1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGTGTACA
    MOB1A Expression
    About this image


    MOB1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Esophagus (Gastrointestinal Tract)
     
     Spleen (Hematopoietic System)
    MOB1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MOB1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.602092

    UniProtKB/Swiss-Prot: MOB1A_HUMAN, Q9H8S9
    Tissue specificity: Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle,
    testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MOB1A gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mob1a1 , 5 MOB kinase activator 1A1, 5 93.06(n)1
    100(a)1
      6 (35.94 cM)5
    2321571  NM_145571.21  NP_663546.11 
     833260165 
    chicken
    (Gallus gallus)
    Aves LOC4296571 mps one binder kinase activator-like 1B-like 82.87(n)
    98.61(a)
      429657  XM_427212.4  XP_427212.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia MOB12 MOB1 protein 81.52(n)    AY319763.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufv69d042 wufv69d04 79.45(n)   334574  BC045979.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mats6
    mob as tumor suppressor
    85(a)
    1 → many
    3R(18246877-18248568)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MOB11 MOB1 55.08(n)
    51.9(a)
      854700   NP_012160.2 
    soybean
    (Glycine max)
    eudicotyledons 445011632   -- 73.75(n)  
    rice
    (Oryza sativa)
    Liliopsida Os10g03963001 Os10g0396300 65.09(n)
    65.88(a)
      4348552  NM_001071066.1  NP_001064531.2 


    ENSEMBL Gene Tree for MOB1A (if available)
    TreeFam Gene Tree for MOB1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MOB1A gene
    MOB3C2  MOB3B2  MOB22  MOB3A2  MOB1B2  
    8 SIMAP similar genes for MOB1A using alignment to 2 protein entries:     MOB1A_HUMAN (see all proteins):
    MOB4A    MOB1B    MOBKL1A    MOB3A    DKFZp686N2312    MOB3C
    MOB3B    MOB2

    MOB1A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MOB1A
    PGOHUM00000248654 PGOHUM00000241707


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MOB1A (see all 606)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494974031,2
    C--74382721(+) AAGAG-/ACAATAA 1 -- int10--------
    rs67401661,2
    C,F,A--74382735(+) ACATAG/CAAGTA 1 -- int1 ese35Minor allele frequency- C:0.33WA NA CSA 125
    rs1829895371,2
    --74382875(+) TAATAC/TTTTGG 1 -- int10--------
    rs113297381,2
    C--74383049(+) CCCTG-/TAAAAA 1 -- int10--------
    rs1156425561,2
    C,F--74383079(+) CCACAC/TGTCAT 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1455286281,2
    C--74383080(+) CACACA/GTCATA 1 -- int10--------
    rs1858608001,2
    C--74383235(+) TATTCA/GTAAAA 1 -- ut310--------
    rs1914108951,2
    --74383387(+) AGTAAA/GTGAGT 1 -- ut310--------
    rs1402263931,2
    --74383453(+) AAGTAC/TGACTA 1 -- ut310--------
    rs115406401,2
    C,F,H--74383630(-) GCTATC/TTGTTA 1 -- ut3116Minor allele frequency- T:0.19NS EA NA WA 2338

    HapMap Linkage Disequilibrium report for MOB1A (74379655 - 74406025 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MOB1A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MOB1A
    DNA2.0 Custom Variant and Variant Library Synthesis for MOB1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609281    OMIM disorders: --

    6 diseases for MOB1A:    
    About MalaCards
    hepatitis c virus    hepatitis c    colorectal cancer    thyroiditis
    hepatitis    prostatitis


    MOB1A for disorders           About GeneDecksing


    Export disorders for MOB1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MOB1A gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with MOB1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of human homologs of yeast MOB1. (PubMed id 19739119)1, 2 Chow A.... Yang X. (Int. J. Cancer 2010)
    2. Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases. (PubMed id 20624913)1, 3 Kohler R.S....Hergovich A. (Mol. Cell. Biol. 2010)
    3. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. (PubMed id 18328708)1, 2 Praskova M.... Avruch J. (Curr. Biol. 2008)
    4. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. (PubMed id 18362890)1, 2 Hirabayashi S.... Hata Y. (Oncogene 2008)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. (PubMed id 15197186)1, 2 Bichsel S.J.... Hemmings B.A. (J. Biol. Chem. 2004)
    9. Crystal structure of a human Mob1 protein: toward understanding Mob- regulated cell cycle pathways. (PubMed id 12962634)1, 2 Stavridi E.S.... Luca F.C. (Structure 2003)
    10. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55233 HGNC: 16015 AceView: MOBK1B Ensembl:ENSG00000114978 euGenes: HUgn55233
    ECgene: MOB1A Kegg: 55233 H-InvDB: MOB1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MOB1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MOB1A gene:
    Search GeneIP for patents involving MOB1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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