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Aliases for MOB1A Gene

Aliases for MOB1A Gene

  • MOB Kinase Activator 1A 2 3 5
  • Mps One Binder Kinase Activator-Like 1B 3 4
  • Mob1 Homolog 1B 3 4
  • Mob1 Alpha 3 4
  • MOBKL1B 3 4
  • C2orf6 3 4
  • MOBK1B 3 4
  • Mob4B 3 4
  • MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast) 2
  • MOB1, Mps One Binder Kinase Activator-Like 1B 3
  • MOB1 Mps One Binder Homolog A (Yeast) 2
  • Chromosome 2 Open Reading Frame 6 2
  • MOB1 Mps One Binder Homolog A 3
  • MATS1 3
  • Mob1A 4
  • MOB1 3

External Ids for MOB1A Gene

Previous HGNC Symbols for MOB1A Gene

  • C2orf6
  • MOBK1B
  • MOBKL1B

Previous GeneCards Identifiers for MOB1A Gene

  • GC02M074382

Summaries for MOB1A Gene

Entrez Gene Summary for MOB1A Gene

  • The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for MOB1A Gene

MOB1A (MOB Kinase Activator 1A) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Hippo signaling pathway. An important paralog of this gene is MOB3A.

UniProtKB/Swiss-Prot for MOB1A Gene

  • Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

Gene Wiki entry for MOB1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB1A Gene

Genomics for MOB1A Gene

Regulatory Elements for MOB1A Gene

Promoters for MOB1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MOB1A on UCSC Golden Path with GeneCards custom track

Genomic Location for MOB1A Gene

Chromosome:
2
Start:
74,152,528 bp from pter
End:
74,178,898 bp from pter
Size:
26,371 bases
Orientation:
Minus strand

Genomic View for MOB1A Gene

Genes around MOB1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB1A Gene

Proteins for MOB1A Gene

  • Protein details for MOB1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8S9-MOB1A_HUMAN
    Recommended name:
    MOB kinase activator 1A
    Protein Accession:
    Q9H8S9
    Secondary Accessions:
    • Q53S34
    • Q9H3T5
    • Q9HAI0
    • Q9NVE2

    Protein attributes for MOB1A Gene

    Size:
    216 amino acids
    Molecular mass:
    25080 Da
    Quaternary structure:
    • Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2.

    Three dimensional structures from OCA and Proteopedia for MOB1A Gene

    Alternative splice isoforms for MOB1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOB1A Gene

Proteomics data for MOB1A Gene at MOPED

Post-translational modifications for MOB1A Gene

  • Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MOB1A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MOB1A (MOB1A)

No data available for DME Specific Peptides for MOB1A Gene

Domains & Families for MOB1A Gene

Gene Families for MOB1A Gene

Protein Domains for MOB1A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MOB1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H8S9

UniProtKB/Swiss-Prot:

MOB1A_HUMAN :
  • Belongs to the MOB1/phocein family.
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB1A: view

Function for MOB1A Gene

Molecular function for MOB1A Gene

UniProtKB/Swiss-Prot Function:
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

Gene Ontology (GO) - Molecular Function for MOB1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15197186
genes like me logo Genes that share ontologies with MOB1A: view
genes like me logo Genes that share phenotypes with MOB1A: view

Animal Models for MOB1A Gene

MGI Knock Outs for MOB1A:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOB1A Gene

Localization for MOB1A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOB1A Gene COMPARTMENTS Subcellular localization image for MOB1A gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MOB1A Gene

Pathways & Interactions for MOB1A Gene

genes like me logo Genes that share pathways with MOB1A: view

Pathways by source for MOB1A Gene

2 Reactome pathways for MOB1A Gene
1 KEGG pathway for MOB1A Gene

SIGNOR curated interactions for MOB1A Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MOB1A Gene

None

Drugs & Compounds for MOB1A Gene

No Compound Related Data Available

Transcripts for MOB1A Gene

Unigene Clusters for MOB1A Gene

MOB kinase activator 1A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOB1A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - - - - -
SP8: -

Relevant External Links for MOB1A Gene

GeneLoc Exon Structure for
MOB1A
ECgene alternative splicing isoforms for
MOB1A

Expression for MOB1A Gene

mRNA expression in normal human tissues for MOB1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOB1A Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for MOB1A Gene

This gene is overexpressed in Spleen (15.9), Ovary (15.7), and Breast (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MOB1A Gene



SOURCE GeneReport for Unigene cluster for MOB1A Gene Hs.602092

mRNA Expression by UniProt/SwissProt for MOB1A Gene

Q9H8S9-MOB1A_HUMAN
Tissue specificity: Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver.
genes like me logo Genes that share expression patterns with MOB1A: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for MOB1A Gene

Orthologs for MOB1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOB1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MOB1A 35
  • 95.68 (n)
  • 100 (a)
MOBKL1B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOB1A 35
  • 96.91 (n)
  • 100 (a)
MOB1A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mob1a 35
  • 93.06 (n)
  • 100 (a)
Mob1a 16
Mob1a 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MOBKL1B 35
  • 99.85 (n)
  • 100 (a)
MOBKL1B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mob1a 35
  • 92.75 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC429657 35
  • 82.87 (n)
  • 98.61 (a)
MOB1A 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mob1a 35
  • 81.79 (n)
  • 98.15 (a)
African clawed frog
(Xenopus laevis)
Amphibia MOB1 35
zebrafish
(Danio rerio)
Actinopterygii LOC100331697 35
  • 79.63 (n)
  • 95.83 (a)
wufv69d04 35
mob1a 36
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mats 36
  • 85 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL236W 35
  • 55.12 (n)
  • 56.42 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03795g 35
  • 57.37 (n)
  • 56.32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 35
  • 55.08 (n)
  • 51.9 (a)
MOB1 36
  • 36 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os10g0396300 35
  • 65.09 (n)
  • 65.88 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01605 35
  • 53.12 (n)
  • 50 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mob1 35
  • 59.94 (n)
  • 57.69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 81 (a)
OneToMany
Species with no ortholog for MOB1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOB1A Gene

ENSEMBL:
Gene Tree for MOB1A (if available)
TreeFam:
Gene Tree for MOB1A (if available)

Paralogs for MOB1A Gene

Paralogs for MOB1A Gene

(8) SIMAP similar genes for MOB1A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MOB1A Gene

genes like me logo Genes that share paralogs with MOB1A: view

Variants for MOB1A Gene

Sequence variations from dbSNP and Humsavar for MOB1A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs828851 -- 74,158,015(-) tacta(A/G)aaatg intron-variant
rs828852 -- 74,156,784(-) GCCTA(C/T)TTTAA intron-variant
rs828891 -- 74,162,821(+) AAGGA(G/T)TGATT intron-variant
rs828892 -- 74,163,468(+) ctcat(C/T)tctac intron-variant
rs828893 -- 74,164,431(+) gagaa(C/T)tgctt intron-variant

Variation tolerance for MOB1A Gene

Residual Variation Intolerance Score: 41.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOB1A Gene

HapMap Linkage Disequilibrium report
MOB1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MOB1A Gene

Disorders for MOB1A Gene

Relevant External Links for MOB1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOB1A

No disorders were found for MOB1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOB1A Gene

Publications for MOB1A Gene

  1. Molecular characterization of human homologs of yeast MOB1. (PMID: 19739119) Chow A. … Yang X. (Int. J. Cancer 2010) 3 4 67
  2. Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases. (PMID: 20624913) Kohler R.S. … Hergovich A. (Mol. Cell. Biol. 2010) 2 3
  3. A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes. (PMID: 11319234) Moreno C.S. … Pallas D.C. (J. Biol. Chem. 2001) 2 3
  4. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. (PMID: 25670202) Rashidian J. … Luo K. (Sci Signal 2015) 3
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3

Products for MOB1A Gene

Sources for MOB1A Gene

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