Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MOB1A Gene

protein-coding   GIFtS: 51
GCID: GC02M074382

MOB Kinase Activator 1A

(Previous names: chromosome 2 open reading frame 6, MOB1, Mps One Binder...)
(Previous symbols: C2orf6, MOBK1B, MOBKL1B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MOB Kinase Activator 1A1 2     MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast)1
C2orf61 2 3     MATS12
MOBK1B1 2 3     MOB12
MOBKL1B1 2 3     Mob4B2
Mob1 Alpha2 3     MOB1 Mps One Binder Homolog A2
Mob1 Homolog 1B2 3     MOB1, Mps One Binder Kinase Activator-Like 1B2
Mps One Binder Kinase Activator-Like 1B2 3     MOB4B3
Chromosome 2 Open Reading Frame 61     Mob1A3
MOB1 Mps One Binder Homolog A (Yeast)1     

External Ids:    HGNC: 160151   Entrez Gene: 552332   Ensembl: ENSG000001149787   OMIM: 6092815   UniProtKB: Q9H8S93   

Export aliases for MOB1A gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MOB1A Gene: 
MOB1A (MOB kinase activator 1A) is a protein-coding gene. Diseases associated with MOB1A include colorectal cancer, and thyroiditis, and among its related super-pathways are Signaling by GPCR. GO annotations related to this gene include protein binding and metal ion binding. An important paralog of this gene is MOB3C.

UniProtKB/Swiss-Prot: MOB1A_HUMAN, Q9H8S9
Function: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and
tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a
kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and
activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1
oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to
regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase
activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38

Gene Wiki entry for MOB1A (MOBKL1B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MOB1A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOB1A promoter sequence
   Search SABiosciences Chromatin IP Primers for MOB1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOB1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.1

MOB1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOB1A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M074382:  view genomic region     (about GC identifiers)

Start:
74,382,165 bp from pter      End:
74,406,025 bp from pter
Size:
23,861 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MOB1A_HUMAN, Q9H8S9 (See protein sequence)
Recommended Name: MOB kinase activator 1A  
Size: 216 amino acids; 25080 Da
Subunit: Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and
STK3/MST2
2 PDB 3D structures from and Proteopedia for MOB1A:
1PI1 (3D)        4JIZ (3D)    
Secondary accessions: Q53S34 Q9H3T5 Q9HAI0 Q9NVE2
Alternative splicing: 2 isoforms:  Q9H8S9-1   Q9H8S9-2   (May be due to an intron retention)

Explore the universe of human proteins at neXtProt for MOB1A: NX_Q9H8S9

Explore proteomics data for MOB1A at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H8S9

  • MOB1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MOB1A Protein Expression
    REFSEQ proteins: NP_060691.2  
    ENSEMBL proteins: 
     ENSP00000379364   ENSP00000386782  
    Reactome Protein details: Q9H8S9
    Human Recombinant Protein Products for MOB1A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MOB1A
    OriGene Protein Over-expression Lysate for MOB1A
    OriGene MassSpec for MOB1A 
    OriGene Custom Protein Services for MOB1A
    GenScript Custom Purified and Recombinant Proteins Services for MOB1A
    Novus Biologicals MOB1A Proteins
    Novus Biologicals MOB1A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    MOB1A for ontologies           About GeneDecksing



    MOB1A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MOB1A 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MOB1A
    GenScript Custom Superior Antibodies Services for MOB1A
    Abcam antibodies for MOB1A
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for MOB1A
    LSBio Antibodies in human, mouse, rat for MOB1A 

    Assay Products for MOB1A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MOB1A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MOB1A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MOB: MOB kinase activators

    1 InterPro protein domain:
     IPR005301 Mob1_phocein

    Graphical View of Domain Structure for InterPro Entry Q9H8S9

    ProtoNet protein and cluster: Q9H8S9

    1 Blocks protein domain: IPB005301 Mob1/phocein family

    UniProtKB/Swiss-Prot: MOB1A_HUMAN, Q9H8S9
    Similarity: Belongs to the MOB1/phocein family


    MOB1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOB1A_HUMAN, Q9H8S9
    Function: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and
    tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a
    kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and
    activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1
    oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to
    regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase
    activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15197186
    GO:0046872metal ion binding IEA--
         
    MOB1A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MOB1A:
     Increased gamma-H2AX phosphory 

         13 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mob1a):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  hearing/vestibular/ear  integument  limbs/digits/tail  mortality/aging 
     nervous system  skeleton  tumorigenesis 

    MOB1A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MOB1A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MOB1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MOB1A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MOB1A 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOB1A
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MOB1A
    SwitchGear 3'UTR luciferase reporter plasmidMOB1A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MOB1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOB1A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MOB1A
    Sirion Biotech Customized adenovirus for overexpression of MOB1A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MOB1A (see all 7)
    OriGene ORF clones in mouse, rat for MOB1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MOB1A
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOB1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOB1A
    Sirion Biotech Customized lentivirus for stable overexpression of MOB1A 
                         Customized lentivirus expression plasmids for stable overexpression of MOB1A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MOB1A
    Search LifeMap BioReagents cell lines for MOB1A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB1A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MOB1A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signal Transduction0.55
    2Signaling by Hippo
    Signaling by Hippo
    3Hippo signaling pathway
    Hippo signaling pathway
    4Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MOB1A
        Wnt / Hedgehog / Notch

    2        Reactome Pathways for MOB1A
        Signaling by Hippo
    Signal Transduction


    1         Kegg Pathway  (Kegg details for MOB1A):
        Hippo signaling pathway


    MOB1A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOB1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/58 Interacting proteins for MOB1A (Q9H8S91, 2, 3 ENSP000003793644) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-68190 I2D: score=5 STRING: ENSP00000311695
    STK38Q152081, 3, ENSP000002298124EBI-748229,EBI-458376 I2D: score=2 STRING: ENSP00000229812
    LATS1O958351, 3, ENSP000002533394EBI-748229,EBI-444209 I2D: score=1 STRING: ENSP00000253339
    LATS2Q9NRM71, 3, ENSP000003720354EBI-748229,EBI-3506895 I2D: score=1 STRING: ENSP00000372035
    KXD1Q9BQD32, 3, ENSP000002223074MINT-67233 I2D: score=4 STRING: ENSP00000222307
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035329hippo signaling cascade TAS--

    MOB1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MOB1A

    Search CenterWatch for drugs/clinical trials and news about MOB1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MOB1A gene: 
    NM_018221.3  

    Unigene Cluster for MOB1A:

    MOB kinase activator 1A
    Hs.602092  [show with all ESTs]
    Unigene Representative Sequence: AK123865
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396049(uc002skh.4) ENST00000497054 ENST00000495286 ENST00000463975(uc002ski.2)
    ENST00000488006 ENST00000494600 ENST00000409969
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MOB1A
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MOB1A
    SwitchGear 3'UTR luciferase reporter plasmidMOB1A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MOB1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOB1A
    Clone
    Products:
         
    OriGene clones in human, mouse for MOB1A (see all 7)
    OriGene ORF clones in mouse, rat for MOB1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MOB1A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOB1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOB1A
    Sirion Biotech Customized lentivirus for stable overexpression of MOB1A 
                         Customized lentivirus expression plasmids for stable overexpression of MOB1A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MOB1A
    OriGene qSTAR qPCR primer pairs in human, mouse for MOB1A
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat MOB1A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOB1A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOB1A

    Additional mRNA sequence: 

    AB016839.1 AJ577474.1 AK001650.1 AK021657.1 AK023321.1 AK123865.1 AL122062.1 BC003398.1 

    18 DOTS entries:

    DT.75147897  DT.95266547  DT.91647641  DT.120938020  DT.100655804  DT.100655806  DT.424949  DT.92452595 
    DT.120937983  DT.91665813  DT.95266540  DT.87015892  DT.92452592  DT.92452593  DT.95266554  DT.99953352 
    DT.100655803  DT.87005796 

    24/461 AceView cDNA sequences (see all 461):

    AA987966 BU618595 BM986942 BM976529 BP369401 BM551597 AK123865 BU628898 
    AA868061 CA429626 AA188376 AI921405 CA407037 AA883296 AA148989 BQ000981 
    CA429713 AA113246 BG286606 BU539769 CA314713 BG257976 AA492533 BU539055 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MOB1A (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b
    SP1:                    -     -     -                                         -                                 
    SP2:                    -     -     -                                         -                                 
    SP3:                    -     -     -                                         -     -     -     -               
    SP4:                                -                                         -                                 
    SP5:                    -     -     -                                                                           


    ECgene alternative splicing isoforms for MOB1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MOB1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGTGTACA
    MOB1A Expression
    About this image


    See MOB1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MOB1A

    SOURCE GeneReport for Unigene cluster: Hs.602092

    UniProtKB/Swiss-Prot: MOB1A_HUMAN, Q9H8S9
    Tissue specificity: Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle,
    testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver

        SABiosciences Custom PCR Arrays for MOB1A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MOB1A
    OriGene qSTAR qPCR primer pairs in human, mouse for MOB1A
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat MOB1A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOB1A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOB1A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MOB1A gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mob1a1 , 5 MOB kinase activator 1A1, 5 93.06(n)1
    100(a)1
      6 (35.94 cM)5
    2321571  NM_145571.21  NP_663546.11 
     833260165 
    chicken
    (Gallus gallus)
    Aves LOC4296571 mps one binder kinase activator-like 1B-like 82.87(n)
    98.61(a)
      429657  XM_427212.3  XP_427212.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia MOB12 MOB1 protein 81.52(n)    AY319763.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufv69d042 wufv69d04 79.45(n)   334574  BC045979.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mats6
    mob as tumor suppressor
    85(a)
    1 → many
    3R(18246877-18248568)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MOB11 Mob1p 55.07(n)
    51.69(a)
      854700   NP_012160.2 
    soybean
    (Glycine max)
    eudicotyledons 445011632   -- 73.75(n)  
    rice
    (Oryza sativa)
    Liliopsida Os10g03963001 hypothetical protein 65.09(n)
    65.88(a)
      4348552  NM_001071066.1  NP_001064531.2 


    ENSEMBL Gene Tree for MOB1A (if available)
    TreeFam Gene Tree for MOB1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MOB1A gene
    MOB3C2  MOB3B2  MOB22  MOB3A2  MOB1B2  
    8 SIMAP similar genes for MOB1A using alignment to 2 protein entries:     MOB1A_HUMAN (see all proteins):
    MOB4A    MOB1B    MOBKL1A    MOB3A    DKFZp686N2312    MOB3C
    MOB3B    MOB2

    MOB1A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MOB1A
    PGOHUM00000248654 PGOHUM00000241707


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/606 SNPs in MOB1A are shown (see all 606)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494974031,2
    C--74382721(+) AAGAG-/ACAATAA 1 -- int10--------
    rs67401661,2
    C,F,A--74382735(+) ACATAG/CAAGTA 1 -- int1 ese35Minor allele frequency- C:0.33WA NA CSA 125
    rs1829895371,2
    --74382875(+) TAATAC/TTTTGG 1 -- int10--------
    rs113297381,2
    C--74383049(+) CCCTG-/TAAAAA 1 -- int10--------
    rs1156425561,2
    C,F--74383079(+) CCACAC/TGTCAT 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1455286281,2
    C--74383080(+) CACACA/GTCATA 1 -- int10--------
    rs1858608001,2
    C--74383235(+) TATTCA/GTAAAA 1 -- ut310--------
    rs1914108951,2
    --74383387(+) AGTAAA/GTGAGT 1 -- ut310--------
    rs1402263931,2
    --74383453(+) AAGTAC/TGACTA 1 -- ut310--------
    rs115406401,2
    C,F,H--74383630(-) GCTATC/TTGTTA 1 -- ut3116Minor allele frequency- T:0.19NS EA NA WA 2338

    HapMap Linkage Disequilibrium report for MOB1A (74382165 - 74406025 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MOB1A: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MOB1A
    DNA2.0 Custom Variant and Variant Library Synthesis for MOB1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609281    OMIM disorders: --

    3 diseases for MOB1A:    About MalaCards
    colorectal cancer    thyroiditis    prostatitis


    MOB1A for disorders           About GeneDecksing


    Export disorders for MOB1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MOB1A gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with MOB1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of human homologs of yeast MOB1. (PubMed id 19739119)1, 2 Chow A....Yang X. (2010)
    2. Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR ki nases. (PubMed id 20624913)1, 3 Kohler R.S....Hergovich A. (2010)
    3. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. (PubMed id 18328708)1, 2 Praskova M....Avruch J. (2008)
    4. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. (PubMed id 18362890)1, 2 Hirabayashi S....Hata Y. (2008)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. (PubMed id 15197186)1, 2 Bichsel S.J.... Hemmings B.A. (2004)
    9. Crystal structure of a human Mob1 protein: toward understanding Mob- regulated cell cycle pathways. (PubMed id 12962634)1, 2 Stavridi E.S.... Luca F.C. (2003)
    10. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55233 HGNC: 16015 AceView: MOBK1B Ensembl:ENSG00000114978 euGenes: HUgn55233
    ECgene: MOB1A Kegg: 55233 H-InvDB: MOB1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MOB1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MOB1A gene:
    Search GeneIP for patents involving MOB1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MOB1A  
     OriGene qPCR primer pairs and template standards for MOB1A   OriGene Protein Over-expression Lysate for MOB1A  
     OriGene MassSpec something-or-other for MOB1A   OriGene clones in human, mouse for MOB1A  
     OriGene qSTAR qPCR primer pairs in human, mouse for MOB1A   OriGene Purified Protein for MOB1A  
     OriGene ORF clones in mouse, rat for MOB1A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MOB1A   OriGene Custom Protein Services for MOB1A  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MOB1A
     QIAGEN SeqTarget long-range PCR primers for resequencing MOB1A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MOB1A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MOB1A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MOB1A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MOB1A
     GenScript Custom Purified and Recombinant Proteins Services for MOB1A GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for MOB1A
     GenScript Custom Assay Services for MOB1A GenScript Custom Superior Antibodies Services for MOB1A
     GenScript Custom overexpressing Cell Line Services for MOB1A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for MOB1A 

     Search Regulatory tfbs for MOB1A
     Search Chromatin IP Primers for MOB1A
     Search RT2 qPCR Primer Assays in human, mouse, rat MOB1A
     Search GNC Networks for MOB1A
     SABiosciences Custom PCR Arrays for MOB1A
     Search Tocris compounds for MOB1A
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MOB1A proteins
     MOB1A lysates
     Antibodies for MOB1A
     See all of Abcam's Antibodies, Kits and Proteins for MOB1A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for MOB1A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOB1A
     SwitchGear 3'UTR luciferase reporter plasmids for MOB1A
     SwitchGear Promoter luciferase reporter plasmids for MOB1A
     ThermoFisher Antibodies for MOB1A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOB1A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MOB1A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MOB1A
    Customized:
     lentivirus for stable overexpression of MOB1A
     lentivirus expression plasmids for stable overexpression of MOB1A
     adenovirus for overexpression of MOB1A
     LSBio Antibodies in human, mouse, rat for MOB1A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MOB1A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4