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MOAP1 Gene

protein-coding   GIFtS: 56
GCID: GC14M093648

Modulator Of Apoptosis 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Modulator Of Apoptosis 11 2     Paraneoplastic Antigen Ma42 3
MAP12 3 5     MAP-12 3
PNMA42 3 5     Paraneoplastic Antigen Like 42
Paraneoplastic Ma Antigen Family Member 41 2     

External Ids:    HGNC: 166581   Entrez Gene: 641122   Ensembl: ENSG000001659437   OMIM: 6094855   UniProtKB: Q96BY23   

Export aliases for MOAP1 gene to outside databases

Previous GC identifers: GC14M087465 GC14M091638 GC14M092718 GC14M073828


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MOAP1 Gene:
The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This
protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When
overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for MOAP1 Gene:
MOAP1 (modulator of apoptosis 1) is a protein-coding gene. Diseases associated with MOAP1 include villonodular synovitis, and synovitis. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is PNMA6A.

UniProtKB/Swiss-Prot: MOAP1_HUMAN, Q96BY2
Function: Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX
conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation

Gene Wiki entry for MOAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  NT_187601.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the MOAP1 gene promoter:
         AML1a   ATF-2   NF-kappaB   FOXL1   AREB6   IRF-2   NF-kappaB2   Meis-1a   NF-kappaB1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMOAP1 promoter sequence
   Search Chromatin IP Primers for MOAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MOAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q32.12

MOAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOAP1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M093648:  view genomic region     (about GC identifiers)

Start:
93,648,541 bp from pter      End:
93,651,273 bp from pter
Size:
2,733 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MOAP1_HUMAN, Q96BY2 (See protein sequence)
Recommended Name: Modulator of apoptosis 1  
Size: 351 amino acids; 39513 Da
Subunit: Homodimer. Under normal circumstances, held in an inactive conformation by an intramolecular interaction.
Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to BAX.
Binds also to BCL2 and BCLX. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective
cognate ligand, after internalization. Interacts with TRIM39. Interacts with RASSF6 (By similarity)
Sequence caution: Sequence=BAB14788.1; Type=Frameshift; Positions=102;
Secondary accessions: B2RDF6 Q9H833 Q9HAS1

Explore the universe of human proteins at neXtProt for MOAP1: NX_Q96BY2

Explore proteomics data for MOAP1 at MOPED

Post-translational modifications: 

  • Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM391
  • Ubiquitination2 at Lys63, Lys253, Lys278, Lys305
  • Modification sites at PhosphoSitePlus

  • See MOAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071434.2  
    ENSEMBL proteins: 
     ENSP00000298894   ENSP00000451594  

    MOAP1 Human Recombinant Protein Products:

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    Novus Biologicals MOAP1 Proteins
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    MOAP1 Antibody Products:

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    MOAP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MOAP1
    Cloud-Clone Corp. CLIAs for MOAP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PNMA: Paraneoplastic Ma antigens

    2 InterPro protein domains:
     IPR026523 PNMA
     IPR026528 PNMA1/MOAP1

    Graphical View of Domain Structure for InterPro Entry Q96BY2

    ProtoNet protein and cluster: Q96BY2

    UniProtKB/Swiss-Prot: MOAP1_HUMAN, Q96BY2
    Domain: The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains
    (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction
    Similarity: Belongs to the PNMA family


    MOAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOAP1_HUMAN, Q96BY2
    Function: Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX
    conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11060313
    GO:0031625ubiquitin protein ligase binding IPI19100260
    GO:0042803protein homodimerization activity ----
         
    MOAP1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MOAP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MOAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MOAP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MOAP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MOAP1:
    hsa-mir-1228-3p (MIRT006333), hsa-mir-192-5p (MIRT026155), hsa-mir-21-5p (MIRT030749), hsa-mir-215-5p (MIRT024361)

    Block miRNA regulation of human, mouse, rat MOAP1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate MOAP1:
    hsa-miR-2052 hsa-miR-1179 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidMOAP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MOAP1
    Predesigned siRNA for gene silencing in human, mouse, rat MOAP1

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    GenScript: all cDNA clones in your preferred vector: MOAP1 (NM_022151)
    Sino Biological Human cDNA Clone for MOAP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MOAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOAP1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for MOAP1 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOAP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA19100260
    GO:0005741mitochondrial outer membrane IDA16199525
    GO:0005829cytosol IDA19100260

    MOAP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MOAP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins
    Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MOAP1
        Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins



        Pathway & Disease-focused RT2 Profiler PCR Array including MOAP1: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MOAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MOAP1 (Q96BY22, 3 ENSP000002988944) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-67008 I2D: score=5 STRING: ENSP00000311695
    DPPA2Q7Z7J52, 3MINT-66426 I2D: score=4 
    ENSG00000224994Q9HCM93, ENSP000004119494I2D: score=1 STRING: ENSP00000411949
    ENSG00000206495Q9HCM93I2D: score=1 
    ENSG00000226437Q9HCM93I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001844protein insertion into mitochondrial membrane involved in apoptotic signaling pathway IMP16199525
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process ----
    GO:0006921cellular component disassembly involved in execution phase of apoptosis ----
    GO:0008625extrinsic apoptotic signaling pathway via death domain receptors IMP16199525
    GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage IMP16199525

    MOAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MOAP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MOAP1 gene: 
    NM_022151.4  

    Unigene Cluster for MOAP1:

    Modulator of apoptosis 1
    Hs.24719  [show with all ESTs]
    Unigene Representative Sequence: NM_022151
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298894(uc001ybj.3) ENST00000556883
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate MOAP1:
    hsa-miR-2052 hsa-miR-1179 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidMOAP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MOAP1
    Predesigned siRNA for gene silencing in human, mouse, rat MOAP1
    Clone
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    GenScript: all cDNA clones in your preferred vector: MOAP1 (NM_022151)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MOAP1
    Primer
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    OriGene qPCR primer pairs and template standards for MOAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for MOAP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MOAP1
      QuantiTect SYBR Green Assays in human, mouse, rat MOAP1
      QuantiFast Probe-based Assays in human, mouse, rat MOAP1

    Additional mRNA sequence: 

    AF305550.1 AK024029.1 AK315522.1 BC015044.1 

    14 DOTS entries:

    DT.95088181  DT.87015957  DT.100841779  DT.120754327  DT.95171656  DT.120754371  DT.97778834  DT.100026605 
    DT.100841776  DT.100708682  DT.95171661  DT.100715877  DT.120754375  DT.100769154 

    Selected AceView cDNA sequences (see all 206):

    AI754688 AI537972 AW515914 AI174575 Z43268 AF305550 AI888832 BM453621 
    CD558170 BM693135 CR612994 AA349914 Z39339 CA435843 AI478157 CK823404 
    AI742946 CR622098 AW264495 AI890802 BX367820 CB152893 BQ020135 BC015044 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MOAP1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for MOAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MOAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGATCATT
    MOAP1 Expression
    About this image


    MOAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Cerebral Cortex
    MOAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MOAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.24719

    UniProtKB/Swiss-Prot: MOAP1_HUMAN, Q96BY2
    Tissue specificity: Ubiquitously expressed with higher levels in heart and brain

        Pathway & Disease-focused RT2 Profiler PCR Array including MOAP1: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MOAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MOAP1 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Moap11 , 5 modulator of apoptosis 11, 5 80.57(n)1
    77.14(a)1
      12 (52.14 cM)5
    641131  NM_022323.71  NP_071718.11 
     1027422305 


    ENSEMBL Gene Tree for MOAP1 (if available)
    TreeFam Gene Tree for MOAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MOAP1 gene
    PNMA6A2  PNMA52  PNMA12  PNMA6D2  PNMA22  PNMAL22  PNMA6C2  PNMA32  
    ZCCHC122  ZCCHC182  PNMAL12  PNMA6B2  
    9 SIMAP similar genes for MOAP1 using alignment to 1 protein entry:     MOAP1_HUMAN:
    PNMA1    PNMA5    PNMA2    PNMA3    PNMA6A    PNMA6B
    PNMA6C    PNMA6D    PNMAL1

    MOAP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MOAP1 (see all 22)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478429041,2
    --93648183(+) TATACC/TGCTCA 1 -- ds50010--------
    rs1828737591,2
    --93648305(+) CACTGA/GTACAT 1 -- ds50010--------
    rs1414157541,2
    --93648344(+) GTCTTA/GTTTCA 1 -- ds50010--------
    rs171289151,2
    C--93648360(+) TTGTTT/CTACTG 1 -- ds50014Minor allele frequency- C:0.02NA WA 260
    rs1470188991,2
    --93648369(+) TGCTTC/TGGTAG 1 -- ds50010--------
    rs1866841761,2
    --93648370(+) GCTTCA/GGTAGA 1 -- ds50010--------
    rs171289161,2
    C,F,H--93648378(+) AGAAGG/TTCCCT 1 -- ds500119Minor allele frequency- T:0.22NA NS EA WA 2480
    rs1381043951,2
    C--93648578(+) TCACAA/CCTATA 1 -- ut310--------
    rs1408539041,2
    --93648687(+) TCTCAG/TCATTC 1 -- ut310--------
    rs1135231651,2
    C--93648755(+) ATAACTTAAT/
            
    ATCTT
    1 -- ut311Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for MOAP1 (93648541 - 93651273 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MOAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv902205CNV Loss21882294
    nsv819426CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MOAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for MOAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609485    OMIM disorders: --

    12 diseases for MOAP1:    
    About MalaCards
    villonodular synovitis    synovitis    pigmented villonodular synovitis    fanconi's anemia
    cholera    medulloblastoma    influenza    glaucoma
    retinoblastoma    ataxia    endometriosis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for MOAP1:
    Pigmented villonodular synovitis

    MOAP1 for disorders           About GeneDecksing


    Export disorders for MOAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MOAP1 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with MOAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains. (PubMed id 11060313)1, 2, 3 Tan K.O....Yu V.C. (J. Biol. Chem. 2001)
    2. The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death. (PubMed id 15949439)1, 2, 9 Baksh S.... Neel B.G. (Mol. Cell 2005)
    3. The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. (PubMed id 22529100)1, 2 Huang N.J.... Kornbluth S. (J. Cell Biol. 2012)
    4. TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process. (PubMed id 19100260)1, 2 Lee S.S.... Yu V.C. (Exp. Cell Res. 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. MAP-1 is a mitochondrial effector of Bax. (PubMed id 16199525)1, 9 Tan K.O....Yu V.C. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    8. Dynamics of RASSF1A/MOAP-1 association with death receptors. (PubMed id 18474619)1, 9 Foley C.J....Baksh S. (Mol. Cell. Biol. 2008)
    9. Genome-wide association study link novel loci to endometriosis. (PubMed id 23472165)1 Albertsen H.M....Ward K. (PLoS ONE 2013)
    10. miR-1228 prevents cellular apoptosis through targeting of MOAP1 protein. (PubMed id 22434376)1 Yan B. and Zhao J.L. (Apoptosis 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64112 HGNC: 16658 AceView: MOAP1 Ensembl:ENSG00000165943 euGenes: HUgn64112
    ECgene: MOAP1 H-InvDB: MOAP1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MOAP1 Pharmacogenomics, SNPs, Pathways

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