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Aliases for MOAP1 Gene

Aliases for MOAP1 Gene

  • Modulator Of Apoptosis 1 2 3 5
  • Paraneoplastic Ma Antigen Family Member 4 2 3
  • Paraneoplastic Antigen Ma4 3 4
  • MAP-1 3 4
  • PNMA4 3 4
  • MAP1 3 4
  • Paraneoplastic Antigen Like 4 3

External Ids for MOAP1 Gene

Previous GeneCards Identifiers for MOAP1 Gene

  • GC14M087465
  • GC14M091638
  • GC14M092718
  • GC14M093648
  • GC14M073828

Summaries for MOAP1 Gene

Entrez Gene Summary for MOAP1 Gene

  • The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for MOAP1 Gene

MOAP1 (Modulator Of Apoptosis 1) is a Protein Coding gene. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is PNMA1.

UniProtKB/Swiss-Prot for MOAP1 Gene

  • Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.

Gene Wiki entry for MOAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOAP1 Gene

Genomics for MOAP1 Gene

Regulatory Elements for MOAP1 Gene

Enhancers for MOAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MOAP1 on UCSC Golden Path with GeneCards custom track

Promoters for MOAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MOAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MOAP1 Gene

Chromosome:
14
Start:
93,182,196 bp from pter
End:
93,184,928 bp from pter
Size:
2,733 bases
Orientation:
Minus strand

Genomic View for MOAP1 Gene

Genes around MOAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOAP1 Gene

Proteins for MOAP1 Gene

  • Protein details for MOAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BY2-MOAP1_HUMAN
    Recommended name:
    Modulator of apoptosis 1
    Protein Accession:
    Q96BY2
    Secondary Accessions:
    • B2RDF6
    • Q9H833
    • Q9HAS1

    Protein attributes for MOAP1 Gene

    Size:
    351 amino acids
    Molecular mass:
    39513 Da
    Quaternary structure:
    • Homodimer. Under normal circumstances, held in an inactive conformation by an intramolecular interaction. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to BAX. Binds also to BCL2 and BCLX. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization. Interacts with TRIM39. Interacts with RASSF6 (By similarity).
    SequenceCaution:
    • Sequence=BAB14788.1; Type=Frameshift; Positions=102; Evidence={ECO:0000305};

neXtProt entry for MOAP1 Gene

Post-translational modifications for MOAP1 Gene

  • Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39.
  • Ubiquitination at Lys 63, Lys 253, Lys 278, and Lys 305
  • Modification sites at PhosphoSitePlus

Other Protein References for MOAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MAP1

No data available for DME Specific Peptides for MOAP1 Gene

Domains & Families for MOAP1 Gene

Gene Families for MOAP1 Gene

Protein Domains for MOAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MOAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BY2

UniProtKB/Swiss-Prot:

MOAP1_HUMAN :
  • The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction.
  • Belongs to the PNMA family.
Domain:
  • The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction.
Family:
  • Belongs to the PNMA family.
genes like me logo Genes that share domains with MOAP1: view

Function for MOAP1 Gene

Molecular function for MOAP1 Gene

UniProtKB/Swiss-Prot Function:
Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.

Gene Ontology (GO) - Molecular Function for MOAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 11060313
GO:0031625 ubiquitin protein ligase binding IPI 19100260
genes like me logo Genes that share ontologies with MOAP1: view
genes like me logo Genes that share phenotypes with MOAP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOAP1 Gene

Localization for MOAP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MOAP1 Gene COMPARTMENTS Subcellular localization image for MOAP1 gene
Compartment Confidence
cytosol 5
mitochondrion 5
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MOAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA 19100260
GO:0005741 mitochondrial outer membrane IDA 16199525
GO:0005829 cytosol IDA 19100260
genes like me logo Genes that share ontologies with MOAP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MOAP1 Gene

Pathways & Interactions for MOAP1 Gene

genes like me logo Genes that share pathways with MOAP1: view

Pathways by source for MOAP1 Gene

1 GeneGo (Thomson Reuters) pathway for MOAP1 Gene

Gene Ontology (GO) - Biological Process for MOAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway IMP 16199525
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IMP 16199525
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP 16199525
GO:0043065 positive regulation of apoptotic process IMP 15949439
GO:0090200 positive regulation of release of cytochrome c from mitochondria IMP 16199525
genes like me logo Genes that share ontologies with MOAP1: view

No data available for SIGNOR curated interactions for MOAP1 Gene

Drugs & Compounds for MOAP1 Gene

No Compound Related Data Available

Transcripts for MOAP1 Gene

mRNA/cDNA for MOAP1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(206) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MOAP1 Gene

Modulator of apoptosis 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOAP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for MOAP1 Gene

GeneLoc Exon Structure for
MOAP1
ECgene alternative splicing isoforms for
MOAP1

Expression for MOAP1 Gene

mRNA expression in normal human tissues for MOAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOAP1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for MOAP1 Gene

This gene is overexpressed in Testis (27.9), Adipocyte (25.8), and Ovary (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MOAP1 Gene



Protein tissue co-expression partners for MOAP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOAP1 Gene:

MOAP1

SOURCE GeneReport for Unigene cluster for MOAP1 Gene:

Hs.24719

mRNA Expression by UniProt/SwissProt for MOAP1 Gene:

Q96BY2-MOAP1_HUMAN
Tissue specificity: Widely expressed, with high levels in heart and brain.
genes like me logo Genes that share expression patterns with MOAP1: view

Primer Products

Orthologs for MOAP1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MOAP1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Moap1 34
  • 80.57 (n)
  • 77.14 (a)
Moap1 16
Moap1 35
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MOAP1 34
  • 99.34 (n)
  • 99.15 (a)
MOAP1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Moap1 34
  • 80.48 (n)
  • 76.57 (a)
Species where no ortholog for MOAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MOAP1 Gene

ENSEMBL:
Gene Tree for MOAP1 (if available)
TreeFam:
Gene Tree for MOAP1 (if available)

Paralogs for MOAP1 Gene

(9) SIMAP similar genes for MOAP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOAP1: view

Variants for MOAP1 Gene

Sequence variations from dbSNP and Humsavar for MOAP1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1128801 -- 93,182,856(-) GCCTT(C/G)CAGGT utr-variant-3-prime
rs112648887 -- 93,182,906(+) GCCTG(A/G)GTGAC utr-variant-3-prime
rs113142191 -- 93,182,911(+) GGTGA(C/T)AGAGC utr-variant-3-prime
rs147018899 -- 93,182,024(+) TGCTT(C/T)GGTAG downstream-variant-500B
rs150416159 -- 93,182,667(+) TCTCA(C/T)GCCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MOAP1 Gene

Variant ID Type Subtype PubMed ID
esv3635350 CNV gain 21293372
nsv819426 CNV loss 19587683

Variation tolerance for MOAP1 Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MOAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOAP1 Gene

Disorders for MOAP1 Gene

Relevant External Links for MOAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MOAP1

No disorders were found for MOAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOAP1 Gene

Publications for MOAP1 Gene

  1. The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death. (PMID: 15949439) Baksh S. … Neel B.G. (Mol. Cell 2005) 3 4 22 65
  2. MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains. (PMID: 11060313) Tan K.O. … Yu V.C. (J. Biol. Chem. 2001) 2 3 4 65
  3. The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. (PMID: 22529100) Huang N.J. … Kornbluth S. (J. Cell Biol. 2012) 3 4 65
  4. TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process. (PMID: 19100260) Lee S.S. … Yu V.C. (Exp. Cell Res. 2009) 3 4 65
  5. Dynamics of RASSF1A/MOAP-1 association with death receptors. (PMID: 18474619) Foley C.J. … Baksh S. (Mol. Cell. Biol. 2008) 3 22 65

Products for MOAP1 Gene

Sources for MOAP1 Gene

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