Aliases for MOAP1 Gene
External Ids for MOAP1 Gene
The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for MOAP1 Gene
MOAP1 (Modulator Of Apoptosis 1) is a Protein Coding gene. Diseases associated with MOAP1 include villonodular synovitis and pigmented villonodular synovitis. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is ZCCHC12.
UniProtKB/Swiss-Prot for MOAP1 Gene
Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.