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Aliases for MNX1 Gene

Aliases for MNX1 Gene

  • Motor Neuron And Pancreas Homeobox 1 2 3 5
  • Homeobox Protein HB9 3 4
  • Homeobox HB9 2 3
  • HLXB9 3 4
  • Homeo Box HB9 2
  • HOXHB9 3
  • SCRA1 3
  • HB9 3

External Ids for MNX1 Gene

Previous HGNC Symbols for MNX1 Gene

  • HLXB9

Previous GeneCards Identifiers for MNX1 Gene

  • GC07M156491
  • GC07M156786
  • GC07M150530

Summaries for MNX1 Gene

Entrez Gene Summary for MNX1 Gene

  • This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for MNX1 Gene

MNX1 (Motor Neuron And Pancreas Homeobox 1) is a Protein Coding gene. Diseases associated with MNX1 include Currarino Syndrome and Currarino Triad. Among its related pathways are Regulation of beta-cell development and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXD3.

UniProtKB/Swiss-Prot for MNX1 Gene

  • Putative transcription factor involved in pancreas development and function.

Gene Wiki entry for MNX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MNX1 Gene

Genomics for MNX1 Gene

Regulatory Elements for MNX1 Gene

Enhancers for MNX1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MNX1 on UCSC Golden Path with GeneCards custom track

Promoters for MNX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MNX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MNX1 Gene

156,994,051 bp from pter
157,010,653 bp from pter
16,603 bases
Minus strand

Genomic View for MNX1 Gene

Genes around MNX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MNX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MNX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MNX1 Gene

Proteins for MNX1 Gene

  • Protein details for MNX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Motor neuron and pancreas homeobox protein 1
    Protein Accession:
    Secondary Accessions:
    • F5H401
    • Q9Y648

    Protein attributes for MNX1 Gene

    401 amino acids
    Molecular mass:
    40569 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MNX1 Gene


neXtProt entry for MNX1 Gene

Proteomics data for MNX1 Gene at MOPED

Post-translational modifications for MNX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MNX1

No data available for DME Specific Peptides for MNX1 Gene

Domains & Families for MNX1 Gene

Gene Families for MNX1 Gene

Protein Domains for MNX1 Gene

Suggested Antigen Peptide Sequences for MNX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with MNX1: view

Function for MNX1 Gene

Molecular function for MNX1 Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor involved in pancreas development and function.
genes like me logo Genes that share phenotypes with MNX1: view

Human Phenotype Ontology for MNX1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MNX1 Gene

MGI Knock Outs for MNX1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for MNX1 Gene

Localization for MNX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MNX1 Gene

Subcellular locations from

Jensen Localization Image for MNX1 Gene COMPARTMENTS Subcellular localization image for MNX1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
extracellular 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for MNX1 Gene

Pathways & Interactions for MNX1 Gene

genes like me logo Genes that share pathways with MNX1: view

Pathways by source for MNX1 Gene

Interacting Proteins for MNX1 Gene

SIGNOR curated interactions for MNX1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MNX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0021520 spinal cord motor neuron cell fate specification IBA --
GO:0031018 endocrine pancreas development IBA --
genes like me logo Genes that share ontologies with MNX1: view

Drugs & Compounds for MNX1 Gene

(1) Drugs for MNX1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MNX1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MNX1: view

Transcripts for MNX1 Gene

mRNA/cDNA for MNX1 Gene

Unigene Clusters for MNX1 Gene

Motor neuron and pancreas homeobox 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MNX1 Gene

No ASD Table

Relevant External Links for MNX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MNX1 Gene

mRNA expression in normal human tissues for MNX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MNX1 Gene

This gene is overexpressed in Pancreas (x24.8), Colon - Transverse (x6.1), and Small Intestine - Terminal Ileum (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MNX1 Gene

SOURCE GeneReport for Unigene cluster for MNX1 Gene Hs.37035

mRNA Expression by UniProt/SwissProt for MNX1 Gene

Tissue specificity: Expressed in lymphoid and pancreatic tissues.
genes like me logo Genes that share expression patterns with MNX1: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for MNX1 Gene

Orthologs for MNX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MNX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MNX1 35
  • 88.3 (n)
  • 84.8 (a)
MNX1 36
  • 85 (a)
(Canis familiaris)
Mammalia MNX1 35
  • 86.03 (n)
  • 86.98 (a)
MNX1 36
  • 88 (a)
(Mus musculus)
Mammalia Mnx1 35
  • 82.33 (n)
  • 86.5 (a)
Mnx1 16
Mnx1 36
  • 89 (a)
(Pan troglodytes)
Mammalia MNX1 35
  • 96.73 (n)
  • 96.73 (a)
MNX1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mnx1 35
  • 82.29 (n)
  • 86.47 (a)
(Monodelphis domestica)
Mammalia MNX1 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia MNX1 36
  • 79 (a)
(Gallus gallus)
Aves MNX1 35
  • 84.23 (n)
  • 88.17 (a)
MNX1 36
  • 69 (a)
(Anolis carolinensis)
Reptilia MNX1 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mnx1 35
  • 73.3 (n)
  • 77.18 (a)
African clawed frog
(Xenopus laevis)
Amphibia hlxb9-A 35
(Danio rerio)
Actinopterygii mnx1 35
  • 66.67 (n)
  • 70.41 (a)
mnx1 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta exex 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for MNX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MNX1 Gene

Gene Tree for MNX1 (if available)
Gene Tree for MNX1 (if available)

Paralogs for MNX1 Gene

genes like me logo Genes that share paralogs with MNX1: view

Variants for MNX1 Gene

Sequence variations from dbSNP and Humsavar for MNX1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_017874 Currarino syndrome (CURRAS)
VAR_017875 Currarino syndrome (CURRAS)
VAR_017876 Currarino syndrome (CURRAS)
VAR_017877 Currarino syndrome (CURRAS)
VAR_017878 Currarino syndrome (CURRAS)

Structural Variations from Database of Genomic Variants (DGV) for MNX1 Gene

Variant ID Type Subtype PubMed ID
nsv889569 CNV Loss 21882294
nsv465249 CNV Loss 19166990
nsv6022 CNV Insertion 18451855
nsv889570 CNV Loss 21882294
dgv1150n67 CNV Gain 20364138
dgv7560n71 CNV Loss 21882294
nsv824418 CNV Gain 20364138

Variation tolerance for MNX1 Gene

Gene Damage Index Score: 0.65; 13.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MNX1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MNX1 Gene

Disorders for MNX1 Gene

MalaCards: The human disease database

(26) MalaCards diseases for MNX1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
currarino syndrome
  • currarino triad
currarino triad
  • currarino syndrome
  • meningocele [ambiguous]
  • teratomas
sacrococcygeal teratoma
- elite association - COSMIC cancer census association via MalaCards
Search MNX1 in MalaCards View complete list of genes associated with diseases


  • Currarino syndrome (CURRAS) [MIM:176450]: The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait. {ECO:0000269 PubMed:10631160, ECO:0000269 PubMed:10749657, ECO:0000269 PubMed:19853743, ECO:0000269 PubMed:22820079}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MNX1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MNX1: view

No data available for Genatlas for MNX1 Gene

Publications for MNX1 Gene

  1. A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues. (PMID: 7914194) Harrison K.A. … Kehrl J.H. (J. Biol. Chem. 1994) 3 4 23 67
  2. A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis. (PMID: 9843207) Ross A.J. … Strachan T. (Nat. Genet. 1998) 2 3 23
  3. Ectopic expression of the HLXB9 gene is associated with an altered nuclear position in t(7;12) leukaemias. (PMID: 19212340) Ballabio E. … Tosi S. (Leukemia 2009) 3 23
  4. Three-way complex translocations in infant acute myeloid leukemia with t(7;12)(q36;p13): the incidence and correlation of a HLXB9 overexpression. (PMID: 19446746) Park J. … Kim H.K. (Cancer Genet. Cytogenet. 2009) 3 23
  5. MNX1 (HLXB9) mutations in Currarino patients. (PMID: 19853743) Garcia-Barcelo M.M. … Tam P.K. (J. Pediatr. Surg. 2009) 3 23

Products for MNX1 Gene

Sources for MNX1 Gene