MNX1 Gene

Aliases
for MNX1 gene

Previous GC identifers: GC07M156491 GC07M150530

Summaries
for MNX1 gene

Genomic Views
for MNX1 gene

RefSeq DNA sequence:

NC_000007.13  NC_018918.1  NT_007741.14  NT_079596.2  

SwitchGear Promoter luciferase reporter plasmids (see all 3): MNX1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MNX1

MNX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M156786:  view genomic region     (about GC identifiers)

Proteins
for MNX1 gene

Explore the universe of human proteins at neXtProt for MNX1: NX_P50219

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: MNX1 OriGene Protein Over-expression Lysate: MNX1 OriGene Custom Protein Services for MNX1
	GenScript Custom Purified and Recombinant Proteins Services for MNX1
	Novus Biologicals MNX1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MNX1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MNX1
	Browse R&D Systems for Antibodies
	OriGene Antibodies: MNX1 OriGene Custom Antibody Services for MNX1
	GenScript Custom Superior Antibodies Services for MNX1
	Novus Biologicals MNX1 Antibodies
	Abcam antibodies for MNX1
	Uscn Antibodies for MNX1
	ThermoFisher Antibodies for MNX1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MNX1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MNX1

Protein Domains /
Families
for MNX1 gene

ProtoNet protein and cluster: P50219

Function
for MNX1 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MNX1
		8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate MNX1 (see all 25):
		hsa-miR-498 hsa-miR-181c hsa-miR-300 hsa-miR-200a hsa-miR-410 hsa-miR-520a-5p hsa-miR-1297 hsa-miR-141
		SwitchGear 3'UTR luciferase reporter plasmid: MNX1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MNX1 OriGene shRNA RFP: MNX1 OriGene siRNA: MNX1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MNX1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MNX1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MNX1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MNX1 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MNX1 (NM_005515)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MNX1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MNX1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MNX1
		Search LifeMap BioReagents cell lines for MNX1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MNX1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 6 alleles) (MGI details for Mnx1)

Pathways & Interactions
for MNX1 gene

	Super-pathway	contained gene-specific pathways
1	Regulation of beta-cell development	Maturity onset diabetes of the young 0.56

1         Kegg Pathway  (Kegg details for MNX1)

Maturity onset diabetes of the young

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

Drugs & Compounds
for MNX1 gene

Transcripts
for MNX1 gene

Expression
for MNX1 gene

MNX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAAATTATT

10/15 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 15)
	Tissue Anatomical Compartment Cell			Category (developmental path)
	PancreasIslets of LangerhansMature Beta Cells			Pancreas
	PancreasPrepancreatic Dorsal Foregut EndodermPre-Pancreatic Foregut Endoderm Cells			Pancreas
	PancreasVentral Pancreatic BudPancreatic Progenitor Cells			Pancreas
	Spinal CordMotor Neural Progenitor DomainMotor Neural Progenitor Cells			Motor Neurons
	Spinal CordMotor Neural Progenitor DomainMotor Neurons			Motor Neurons
	Gut TubeDorsal Foregut EndodermDorsal Foregut Endoderm Cells			Endoderm
	Gut TubeVentral Foregut EndodermVentral Foregut Endoderm Cells			Endoderm
	LimbLimb BudZone Of Polarizing Activity Cells			Mesoderm
	PancreasDorsal Pancreatic BudBeta/Delta Progenitor Cells			Pancreas
	PancreasDorsal Pancreatic BudImmature Beta Progenitor Cells			Pancreas
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 10/25 LifeMap Cells (see all 25)
	Name			Category
	Fetal spinal cord stem cells (NSI-566) (Fetal Stem / Progenitor Cell)			Spinal Cord
	Motor neuron-like cells (Generation of motor ...)			Motor Neurons, Spinal Cord
	Indolactam V-induced cells (Derivation of pancre...)
	Posterior foregut endoderm-like cells (Generation of beta c...)
	Motor neuron-like cells (Generation of motor ...)
	Motor neuron progenitors (Generation of motor ...)
	Motor neuron-like cells (Generation of motor ...)
	GFP positive cells (Generation of motor ...)
	Neuronal progenitors (Generation of motor ...)
	Motor neuron-like and Interneuron-like cells (Generation of motor ...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MNX1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MNX1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MNX1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MNX1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MNX1

Orthologs
for MNX1 gene

Paralogs
for MNX1 gene

Paralogs for MNX1 gene

NKX1-2²  MEOX1²  EVX1²  MEOX2²  EVX2²  NKX1-1²  GBX1²  GBX2²  

18/39 SIMAP similar genes for MNX1 using alignment to 4 protein entries:     MNX1_HUMAN (see all proteins) (see all similar genes):

homeobox gene    HMX2    HOX B6    HOXA4    DLX6    MSX1

NKX2-5    HOXB8    HOXC13    MEOX1    CDX2    HHEX

HOXB1    PHOX2B    PAX6    BARX2    NKX6-1    NOBOX

MNX1 for paralogs           About GeneDecksing

Genomic Variants
for MNX1 gene

10/117 NCBI SNPs in MNX1 are shown (see all 117)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs102247701,2	C,	--	156026769(+)	GGCGCG/AGAGGT	2	--	ds5001		3		NA WA	240
rs10472401,2	C	--	156027140(-)	GGAGCC/TGCCAT	2	--	ut31 ese3		3		MN NA	188
rs1162649131,2	C,F,	--	156027250(+)	GGGTCG/TGTTCT	2	--	ut31		1		WA	118
rs665870431,2	C,	--	156027340(+)	GGTCTC/TCCTCT	2	--	ut31		3		WA NA	240
rs678907171,2	C	--	156027408(-)	CGCGGC/-CTCCG	2	--	ut31		1		NA	2
rs285527201,2	C,F,	--	156028255(+)	CTCAGG/TATGTT	2	--	int1		8		NA WA CSA	250
rs22702101,2	C,F,A,H,	--	156028440(-)	CATCTA/GGCGCT	2	--	int1		24		EA NS NA WA CSA	3822
rs2008641271,2	C	--	156028924(-)	CTAGAA/CAAAAA	2	--	int1		0	--	--	--	--
rs287001511,2	C,F,	--	156029630(+)	GAGGCG/ACAGGC	2	--	int1		6		NA WA	424
rs132211181,2	C,F,A,H,	--	156029981(+)	CCAACA/GGGCAG	2	--	int1		16		NS EA NA WA CSA	1790

HapMap Linkage Disequilibrium report for MNX1 (156786745 - 156803347 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for MNX1: --
Human Gene Mutation Database (HGMD): MNX1

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MNX1

DNA2.0 Custom Variant and Variant Library Synthesis for MNX1

Disorders / Diseases
for MNX1 gene

20/34 diseases for MNX1

10/11 Novoseek disease relationships for MNX1 gene (see all 11)    About this table

Publications
for MNX1 gene

PubMed articles for MNX1 gene, integrated from 9 sources (see all 69): (articles sorted by number of sources associating them with MNX1)

Utopia: connect your pdf to the dynamic world of online information

1. A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues. (PubMed id 7914194)^{1, 2, 9} Harrison K.A.... Kehrl J.H. (1994)
2. Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene. (PubMed id 10749657)^{1, 2, 9} Hagan D.M.... Lindsay S. (2000)
3. MNX1 (HLXB9) mutations in Currarino patients. (PubMed id 19853743)^{1, 2, 9} Garcia-BarcelA^ M.M....Tam P.K. (2009)
4. A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis. (PubMed id 9843207)^{1, 3, 9} Ross A.J....Strachan T. (1998)
5. Novel mutations in the MNX1 gene in two families with Currarino syndrome and variable phenotype. (PubMed id 22820079)^{1, 2} Markljung E....Nordenskjold A. (2012)
6. Involvement of the HLXB9 homeobox gene in Currarino syndrome. (PubMed id 10631160)^{1, 2} Belloni E.... Scherer S.W. (2000)
7. A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36. (PubMed id 10329000)^{1, 2} Heus H.C.... Heutink P. (1999)
8. HLXB9 activates IL6 in Hodgkin lymphoma cell lines and is regulated by PI3K signalling involving E2F3. (PubMed id 15772702)^{1, 9} Nagel S....MacLeod R.A. (2005)
9. Three-way complex translocations in infant acute myeloid leukemia with t(7;12)(q36;p13): the incidence and correlation of a HLXB9 overexpression. (PubMed id 19446746)^{1, 9} Park J....Kim H.K. (2009)
10. High incidence of t(7;12)(q36;p13) in infant AML but not in infant ALL, with a dismal outcome and ectopic expression of HLXB9. (PubMed id 16646086)^{1, 9} von Bergh A.R....Beverloo H.B. (2006)

External Searches for MNX1 gene

Genome Databases showing MNX1 gene

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Specialized Databases showing MNX1 gene

Products
for MNX1 gene