Aliases for MNT Gene
External Ids for MNT Gene
Previous GeneCards Identifiers for MNT Gene
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]
GeneCards Summary for MNT Gene
MNT (MAX Network Transcriptional Repressor) is a Protein Coding gene. Diseases associated with MNT include Retinitis Pigmentosa, Y-Linked and Wolfram Syndrome 2. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity.
UniProtKB/Swiss-Prot for MNT Gene
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5-CACGTG-3 and, with higher affinity, to 5-CACGCG-3.