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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MNT Gene

protein-coding   GIFtS: 52
GCID: GC17M002287

MNT, MAX dimerization protein

(Previous name: MAX binding protein )
 Explore 13 diseases affiliated with
MNT via our new
 Human Malady Compendium 
Biological research products
for MNT
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
MNT, MAX Dimerization Protein1 2     Class D Basic Helix-Loop-Helix Protein 32 3
ROX1 2 3 5     Myc Antagonist MNT2 3
BHLHd31     Max-Binding Protein MNT2
MAD61 2     Max-Interacting Protein2
MXD61 2     BHLHD33
MAX Binding Protein1 2     Protein ROX3

External Ids:    HGNC: 71881   Entrez Gene: 43352   Ensembl: ENSG000000704447   OMIM: 6030395   UniProtKB: Q995833   

Export aliases for MNT gene to outside databases

Previous GC identifers: GC17M002594 GC17M002238 GC17M002493 GC17M002234 GC17M002183


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MNT:
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific
transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein
has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as
the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an
antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by
binding to DNA binding proteins at its N-terminal Sin3-interaction domain. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MNT_HUMAN, Q99583
Function: Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence
5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'

Gene Wiki entry for MNT


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MNT gene promoter:
         GR   Max1   p53   GR-beta   MyoD   Max   GR-alpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMNT promoter sequence
   Search SABiosciences Chromatin IP Primers for MNT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MNT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

MNT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MNT gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M002287:  view genomic region     (about GC identifiers)

Start:
2,287,354 bp from pter      End:
2,304,412 bp from pter
Size:
17,059 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MNT_HUMAN, Q99583 (See protein sequence)
Recommended Name: Max-binding protein MNT  
Size: 582 amino acids; 62300 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a
heterodimer with MAX
Subcellular location: Nucleus
Secondary accessions: A8K6D1 D3DTI7 Q1ED38

Explore the universe of human proteins at neXtProt for MNT: NX_Q99583

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99583

  • MNT Protein expression data from MOPED and PaxDb:    About this image 
    MNT Protein Expression
    REFSEQ proteins: NP_064706.1  
    ENSEMBL proteins: 
     ENSP00000174618   ENSP00000468574   ENSP00000465195   ENSP00000384177  

    Human Recombinant Protein Products for MNT: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MNT

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    MNT for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MNT for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry Q99583

    ProtoNet protein and cluster: Q99583

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: MNT_HUMAN, Q99583
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MNT_HUMAN, Q99583
    Function: Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence
    5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'

         Genatlas biochemistry entry for MNT:
    Max interactor 2 (interacting with Max to bind Myc-Max recognition sites),MYC family acting as a transcriptional
    repressor in an E.box driver reporter gene repression system through interaction between the N-terminus and SIN3
    corepressor,potentially involved in proliferation and differentiation,not involved in lung cancer

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS9598315
    GO:0003714transcription corepressor activity TAS9598315
         
    MNT for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mnt):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  integument  mortality/aging  no phenotypic analysis 
     reproductive system  skeleton  tumorigenesis 

    MNT for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for MNT: Mnttm1.1Phu Mnttm1.1Awb
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MNT 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MNT
    8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate MNT (see all 117):
    hsa-miR-576-3p hsa-miR-520e hsa-miR-520f hsa-miR-3607-3p hsa-miR-3938 hsa-miR-1321 hsa-miR-15a hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidMNT 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MNT (see all 7)
    OriGene shRNA RFP: MNT
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    Sirion Biotech Custom design and validation of potent shRNA sequences against MNT 

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MNT 

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    Sirion Biotech Customized inducible overexpressing cell line services for MNT

    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MNT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MNT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/11 Interacting proteins for MNT (Q995832, 3 ENSP000001746184) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAXP612443, ENSP000003514904I2D: score=5 STRING: ENSP00000351490
    MLXQ9UH923, ENSP000002469124I2D: score=3 STRING: ENSP00000246912
    MAD1L1Q9Y6D93, ENSP000003825624I2D: score=1 STRING: ENSP00000382562
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    SIN3BO751823, ENSP000003691314I2D: score=1 STRING: ENSP00000369131
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS9184233
    GO:0007275multicellular organismal development TAS9184233
    GO:0007569cell aging IEA--
    GO:0008285negative regulation of cell proliferation TAS9184233

    MNT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MNT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MNT
    1 Novoseek chemical compound relationship for MNT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 15.7 1 17577784 (1)

    Search CenterWatch for drugs/clinical trials and news about MNT 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MNT gene: 
    NM_020310.2  

    Unigene Cluster for MNT:

    MNT, MAX dimerization protein
    Hs.632239  [show with all ESTs]
    Unigene Representative Sequence: NM_020310
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000174618(uc002fur.3) ENST00000575374 ENST00000572892 ENST00000571232
    ENST00000573384 ENST00000575394 ENST00000574559 ENST00000571836 ENST00000404961


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MNT
    8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate MNT (see all 117):
    hsa-miR-576-3p hsa-miR-520e hsa-miR-520f hsa-miR-3607-3p hsa-miR-3938 hsa-miR-1321 hsa-miR-15a hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidMNT 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MNT (see all 7)
    OriGene shRNA RFP: MNT
    OriGene siRNA: MNT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MNT
    Sirion Biotech Custom design and validation of potent shRNA sequences against MNT 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MNT
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    GenScript: all cDNA clones in your preferred vector: MNT (NM_020310)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MNT
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    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MNT
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MNT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MNT

    Additional cDNA sequence: 

    AF318360.1 AK001561.1 AK291596.1 BC033186.1 BC117563.1 X69879.1 X96401.1 

    8 DOTS entries:

    DT.97843165  DT.91901555  DT.40118536  DT.100746856  DT.97782310  DT.120975142  DT.120975159  DT.120975165 

    24/139 AceView cDNA sequences (see all 139):

    CA943880 CR598337 AW452855 AI268304 F03123 BQ675978 BI760613 BQ681300 
    BC033186 BM876168 AF318360 AA721022 BM668013 CD724261 CA950091 AA339431 
    AI679668 BM820333 BM696982 AA934929 AW468019 BX401742 AW500055 CA442808 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MNT (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:        -     -                                   -     -     -     -                                 
    SP2:                                                        -     -                                       
    SP3:                                                              -     -                                 
    SP4:                                                                                                      
    SP5:        -     -     -     -     -     -     -     -     -     -     -                                 


    ECgene alternative splicing isoforms for MNT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MNT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAATAAGCAC
    MNT Expression
    About this image
    See MNT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MNT

    SOURCE GeneReport for Unigene cluster: Hs.632239
        SABiosciences Custom PCR Arrays for MNT

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MNT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MNT gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mnt1 , 5 max binding protein1, 5 89.86(n)1
    94.33(a)1
      11 (45.76 cM)5
    174281  NM_010813.31  NP_034943.31 
     748309205 
    chicken
    (Gallus gallus)
    Aves MNT1 MAX binding protein 69.9(n)
    72.76(a)
      427840  XM_425414.2  XP_425414.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    MNT6
    --
    79(a)
    47(a)
    possible ortholog
    1 ↔ 1
    GL344126.1(62338-65889)
    GL343731.1(233-13163)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.108532 Xenopus laevis transcribed sequence with weak similarity more 76.94(n)    BX847501.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mntb1 MAX binding protein b 62.23(n)
    58.56(a)
      556663  NM_001103111.1  NP_001096581.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mnt6
    Mnt
    15(a)
    1 ↔ 1
    X(3565834-3597318)


    ENSEMBL Gene Tree for MNT (if available)
    TreeFam Gene Tree for MNT (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/296 NCBI SNPs in MNT are shown (see all 296    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1508315031,2
    --2286869(+) CACCCG/TCTGTG 1 -- ds50010--------
    rs1381363671,2
    --2286949(+) ACAAGA/GGTGGC 1 -- ds50010--------
    rs739765231,2
    C--2286990(+) CAGAGG/ATCTGA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1495926291,2
    --2287250(+) ACTATA/GCTGGG 1 -- ds50010--------
    rs1472642251,2
    --2287267(+) GGGTCA/GAGACA 1 -- ds50010--------
    rs1405095741,2
    --2287488(+) ATACAA/GTTCAA 1 -- ut310--------
    rs1858679111,2
    --2287842(+) CTGAAC/TATCAA 1 -- ut310--------
    rs1887365351,2
    --2287910(+) TGTGTA/GTGTGT 1 -- ut310--------
    rs1927827211,2
    --2287973(+) GTGAGA/GACAGA 1 -- ut310--------
    rs1474040671,2
    --2288007(+) GGAGAC/TGCCCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MNT (2287354 - 2304412 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MNT: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MNT
    DNA2.0 Custom Variant and Variant Library Synthesis for MNT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MNT for disorders           About GeneDecksing

    OMIM gene information: 603039    OMIM disorders: --

    13 diseases for MNT:    About MalaCards
    miller-dieker lissencephaly    miller-dieker syndrome    williams-beuren syndrome    tetanus neonatorum
    rheumatic fever    lissencephaly    tetanus    cholestasis
    rabies    medulloblastoma    lung cancer    neuroblastoma
    leukemia

    3 diseases from the University of Copenhagen DISEASES database for MNT:
    Tetanus neonatorum     Rabies     Rheumatic fever

    2 Novoseek disease relationships for MNT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 14749372 (1), 16908182 (1), 17419941 (1), 10446446 (1)
    cancer 0 1 9824157 (1)


    Export disorders for MNT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MNT gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with MNT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human ROX gene: genomic structure and mutation analysis in human breast tumors. (PubMed id 9598315)1, 2, 3 Nigro C.L.... Carrozzo R. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. (PubMed id 9184233)1, 2 Meroni G.... Carrozzo R. (1997)
    4. Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia. (PubMed id 17577784)1, 9 Guo X.L....Ohno R. (2007)
    5. Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes. (PubMed id 19086036)1, 9 Yang H....Lu S.C. (2009)
    6. Mnt takes control as key regulator of the myc/max/mxd network. (PubMed id 17419941)1, 9 Wahlstrom T. and Henriksson M. (2007)
    7. Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? (PubMed id 10918583)1, 9 Meroni G....Reymond A. (2000)
    8. Expression and DNA-binding activity of MYCN/Max and Mnt/Max during induced differentiation of human neuroblastoma cells. (PubMed id 15258910)1, 9 Smith A.G....Henriksson M. (2004)
    9. Identification of Max binding protein as a novel bindi ng protein of Nck1 and characterization of its role in inhibiting human liver ca ncer SK-HEP-1 cells. (PubMed id 22964333)1 Zhou Q....Peng B.G. (2012)
    10. A Myc network accounts for similarities between embry onic stem and cancer cell transcription programs. (PubMed id 20946988)1 Kim J....Orkin S.H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4335 HGNC: 7188 AceView: MNT Ensembl:ENSG00000070444 euGenes: HUgn4335
    ECgene: MNT H-InvDB: MNT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MNT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MNT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MNT gene:
    Search GeneIP for patents involving MNT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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