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MNT Gene

protein-coding   GIFtS: 55
GCID: GC17M002287

MAX Network Transcriptional Repressor

(Previous names: MAX binding protein, MNT, MAX dimerization protein)
  See MNT-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MAX Network Transcriptional Repressor1 2     bHLHd32 3
ROX2 3 5     Myc Antagonist1
MAX Binding Protein1 2     MAD62
MNT, MAX Dimerization Protein1 2     MXD62
Max-Interacting Protein1 2     Max-Binding Protein MNT2
Class D Basic Helix-Loop-Helix Protein 32 3     BHLHD33
Myc Antagonist MNT2 3     Protein ROX3

External Ids:    HGNC: 71881   Entrez Gene: 43352   Ensembl: ENSG000000704447   OMIM: 6030395   UniProtKB: Q995833   

Export aliases for MNT gene to outside databases

Previous GC identifers: GC17M002594 GC17M002238 GC17M002493 GC17M002234 GC17M002183


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MNT Gene:
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific
transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This
protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence
CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a
transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This
protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.
(provided by RefSeq, Jul 2008)

GeneCards Summary for MNT Gene:
MNT (MAX network transcriptional repressor) is a protein-coding gene. Diseases associated with MNT include tetanus neonatorum. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: MNT_HUMAN, Q99583
Function: Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence
5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'

Gene Wiki entry for MNT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MNT gene promoter:
         GR   Max1   p53   GR-beta   MyoD   Max   GR-alpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMNT promoter sequence
   Search Chromatin IP Primers for MNT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MNT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

MNT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MNT gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M002287:  view genomic region     (about GC identifiers)

Start:
2,287,354 bp from pter      End:
2,304,412 bp from pter
Size:
17,059 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MNT_HUMAN, Q99583 (See protein sequence)
Recommended Name: Max-binding protein MNT  
Size: 582 amino acids; 62300 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a
heterodimer with MAX
Secondary accessions: A8K6D1 D3DTI7 Q1ED38

Explore the universe of human proteins at neXtProt for MNT: NX_Q99583

Explore proteomics data for MNT at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MNT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064706.1  
    ENSEMBL proteins: 
     ENSP00000174618   ENSP00000476269  

    MNT Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for MNT

     
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    antibodies-online proteins for MNT (4 products) 

     
    antibodies-online peptides for MNT

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    antibodies-online antibodies for MNT (20 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MXD: MAX dimerization proteins
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q99583

    ProtoNet protein and cluster: Q99583

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: MNT_HUMAN, Q99583
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with MNT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MNT_HUMAN, Q99583
    Function: Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence
    5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'

         Genatlas biochemistry entry for MNT:
    Max interactor 2 (interacting with Max to bind Myc-Max recognition sites),MYC family acting as a transcriptional
    repressor in an E.box driver reporter gene repression system through interaction between the N-terminus and SIN3
    corepressor,potentially involved in proliferation and differentiation,not involved in lung cancer

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS9598315
    GO:0003714transcription corepressor activity TAS9598315
         
    Find genes that share ontologies with MNT           About GenesLikeMe


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mnt):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  integument  mortality/aging  no phenotypic analysis 
     reproductive system  skeleton  tumorigenesis 

    Find genes that share phenotypes with MNT           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MNT: Mnttm1.1Phu Mnttm1.1Awb

       genOway: Develop your customized and physiologically relevant rodent model for MNT

    miRNA
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    miRTarBase miRNAs that target MNT:
    hsa-mir-210-3p (MIRT004672), hsa-mir-17-5p (MIRT050948), hsa-mir-331-3p (MIRT043556)

    Block miRNA regulation of human, mouse, rat MNT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MNT (see all 117):
    hsa-miR-576-3p hsa-miR-520e hsa-miR-520f hsa-miR-3607-3p hsa-miR-3938 hsa-miR-1321 hsa-miR-15a hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidMNT 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MNT
    Predesigned siRNA for gene silencing in human, mouse, rat MNT

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MNT (NM_020310)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MNT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MNT

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MNT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MNT_HUMAN, Q99583: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endosome1
    extracellular1
    lysosome1
    vacuole1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with MNT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MNT
    Interactions:

        GeneGlobe Interaction Network for MNT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for MNT (Q995832, 3 ENSP000001746184) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAXP612443, ENSP000003514904I2D: score=5 STRING: ENSP00000351490
    MLXQ9UH923, ENSP000002469124I2D: score=3 STRING: ENSP00000246912
    MAD1L1Q9Y6D93, ENSP000003825624I2D: score=1 STRING: ENSP00000382562
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    SIN3BO751823, ENSP000003691314I2D: score=1 STRING: ENSP00000369131
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS9184233
    GO:0007275multicellular organismal development TAS9184233
    GO:0007569cell aging IEA--
    GO:0008285negative regulation of cell proliferation TAS9184233

    Find genes that share ontologies with MNT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MNT

    1 Novoseek inferred chemical compound relationship for MNT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 15.7 1 17577784 (1)



    Find genes that share compounds with MNT           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MNT gene: 
    NM_020310.2  

    Unigene Cluster for MNT:

    MNT, MAX dimerization protein
    Hs.632239  [show with all ESTs]
    Unigene Representative Sequence: NM_020310
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000174618(uc002fur.3) ENST00000575374 ENST00000572892 ENST00000571232
    ENST00000573384 ENST00000575394 ENST00000575402 ENST00000574559 ENST00000571836

    miRNA
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    Block miRNA regulation of human, mouse, rat MNT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MNT (see all 117):
    hsa-miR-576-3p hsa-miR-520e hsa-miR-520f hsa-miR-3607-3p hsa-miR-3938 hsa-miR-1321 hsa-miR-15a hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidMNT 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MNT
    Clone
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    OriGene ORF clones in mouse, rat for MNT
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    GenScript: all cDNA clones in your preferred vector: MNT (NM_020310)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MNT
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MNT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MNT
      QuantiTect SYBR Green Assays in human, mouse, rat MNT
      QuantiFast Probe-based Assays in human, mouse, rat MNT

    Additional mRNA sequence: 

    AF318360.1 AK001561.1 AK291596.1 BC033186.1 BC117563.1 X69879.1 X96401.1 

    8 DOTS entries:

    DT.97843165  DT.91901555  DT.40118536  DT.100746856  DT.97782310  DT.120975142  DT.120975159  DT.120975165 

    Selected AceView cDNA sequences (see all 139):

    CR598337 BQ681300 CA950091 AI268304 BM820333 F03123 BM876168 AW468019 
    AW452855 BQ675978 BM668013 AI679668 AA934929 BC033186 AA721022 BI760613 
    BM696982 CA943880 CD724261 AA339431 AF318360 AA627801 AW500055 AU130337 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MNT (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:        -     -                                   -     -     -     -                                 
    SP2:                                                        -     -                                       
    SP3:                                                              -     -                                 
    SP4:                                                                                                      
    SP5:        -     -     -     -     -     -     -     -     -     -     -                                 


    ECgene alternative splicing isoforms for MNT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MNT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATAAGCAC
    MNT Expression
    About this image


    MNT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    MNT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MNT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632239
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MNT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MNT gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mnt1 , 5 max binding protein1, 5 89.86(n)1
    94.33(a)1
      11 (45.76 cM)5
    174281  NM_010813.31  NP_034943.31 
     748309205 
    chicken
    (Gallus gallus)
    Aves MNT1 MAX binding protein 69.16(n)
    70.83(a)
      427840  XM_425414.3  XP_425414.2 
    lizard
    (Anolis carolinensis)
    Reptilia MNT6
    MAX network transcriptional repressor
    77(a)
    1 ↔ 1
    GL344126.1(62338-65889)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.108532 Xenopus laevis transcribed sequence with weak similarity more 76.94(n)    BX847501.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mntb6
    MAX binding protein b
    50(a)
    1 ↔ 1
    21(38297383-38344313) ENSDARG00000073988
    fruit fly
    (Drosophila melanogaster)
    Insecta Mnt6
    Mnt
    16(a)
    1 ↔ 1
    X(3565834-3597318)


    ENSEMBL Gene Tree for MNT (if available)
    TreeFam Gene Tree for MNT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MNT (see all 412)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1508315031,2
    --2286869(+) CACCCG/TCTGTG 1 -- ds50010--------
    rs1381363671,2
    --2286949(+) ACAAGA/GGTGGC 1 -- ds50010--------
    rs739765231,2
    C,F--2286990(+) CAGAGG/ATCTGA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1495926291,2
    C--2287250(+) ACTATA/GCTGGG 1 -- ds50010--------
    rs1472642251,2
    C--2287267(+) GGGTCA/GAGACA 1 -- ds50010--------
    rs1405095741,2
    C--2287488(+) ATACAA/GTTCAA 1 -- ut310--------
    rs1858679111,2
    --2287842(+) CTGAAC/TATCAA 1 -- ut310--------
    rs1382472441,2
    C--2287891(+) CGTGC-/GT/GTG
    T
    /GTGTGT
    CGTGT
    3 -- ut31 cds10--------
    rs671696791,2
    C--2287892(+) GTGCG-/GT    
       
    /GTGT
    TGTGT
    2 -- ut310--------
    rs1887365351,2
    --2287910(+) TGTGTA/GTGTGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MNT (2287354 - 2304412 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MNT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv907532CNV Loss21882294
    dgv3036n71CNV Loss21882294
    nsv833336CNV Loss17160897
    nsv470569CNV Loss18288195
    nsv907537CNV Loss21882294
    nsv833338CNV Loss17160897
    nsv907530CNV Loss21882294
    nsv517489CNV Loss19592680
    nsv907529CNV Gain21882294
    nsv469765CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MNT
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603039    OMIM disorders: --

    1 disease for MNT:    
    About MalaCards
    tetanus neonatorum

    3 diseases from the University of Copenhagen DISEASES database for MNT:
    Tetanus neonatorum     Rabies     Rheumatic fever

    Find genes that share disorders with MNT           About GenesLikeMe

    2 Novoseek inferred disease relationships for MNT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 14749372 (1), 16908182 (1), 17419941 (1), 10446446 (1)
    cancer 0 1 9824157 (1)


    Export disorders for MNT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MNT gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with MNT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human ROX gene: genomic structure and mutation analysis in human breast tumors. (PubMed id 9598315)1, 2, 3 Nigro C.L.... Carrozzo R. (Genomics 1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. (PubMed id 9184233)1, 2 Meroni G.... Carrozzo R. (EMBO J. 1997)
    4. Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia. (PubMed id 17577784)1, 9 Guo X.L....Ohno R. (amp 2007)
    5. Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes. (PubMed id 19086036)1, 9 Yang H....Lu S.C. (Hepatology 2009)
    6. Mnt takes control as key regulator of the myc/max/mxd network. (PubMed id 17419941)1, 9 WahlstrAPm T. and Henriksson M. (Adv. Cancer Res. 2007)
    7. Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? (PubMed id 10918583)1, 9 Meroni G....Reymond A. (Oncogene 2000)
    8. Expression and DNA-binding activity of MYCN/Max and Mnt/Max during induced differentiation of human neuroblastoma cells. (PubMed id 15258910)1, 9 Smith A.G....Henriksson M. (J. Cell. Biochem. 2004)
    9. Chromatin dynamics at the hTERT promoter during transcriptional activation and repression by c-Myc and Mnt in Xenopus leavis oocytes. (PubMed id 23860446)1 WahlstrAPm T....Arsenian Henriksson M. (Exp. Cell Res. 2013)
    10. Identification of Max binding protein as a novel binding protein of Nck1 and characterization of its role in inhibiting human liver cancer SK-HEP-1 cells. (PubMed id 22964333)1 Zhou Q....Peng B.G. (Chin. Med. J. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4335 HGNC: 7188 AceView: MNT Ensembl:ENSG00000070444 euGenes: HUgn4335
    ECgene: MNT H-InvDB: MNT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MNT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MNT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MNT gene:
    Search GeneIP for patents involving MNT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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