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Aliases for MNT Gene

Aliases for MNT Gene

  • MAX Network Transcriptional Repressor 2 3 5
  • Class D Basic Helix-Loop-Helix Protein 3 3 4
  • MNT, MAX Dimerization Protein 2 3
  • Max-Interacting Protein 2 3
  • MAX Binding Protein 2 3
  • Myc Antagonist MNT 3 4
  • BHLHd3 3 4
  • ROX 3 4
  • Max-Binding Protein MNT 3
  • Myc Antagonist 2
  • Protein ROX 4
  • MAD6 3
  • MXD6 3

External Ids for MNT Gene

Previous GeneCards Identifiers for MNT Gene

  • GC17M002594
  • GC17M002238
  • GC17M002493
  • GC17M002234
  • GC17M002183
  • GC17M002287

Summaries for MNT Gene

Entrez Gene Summary for MNT Gene

  • The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for MNT Gene

MNT (MAX Network Transcriptional Repressor) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for MNT Gene

  • Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5-CACGTG-3 and, with higher affinity, to 5-CACGCG-3.

Gene Wiki entry for MNT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MNT Gene

Genomics for MNT Gene

Regulatory Elements for MNT Gene

Enhancers for MNT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F002374 0.2 ENCODE 21.1 +25.9 25880 1.9 MAFF REST NR3C1 MAFK SGSM2 MNT ENSG00000263345 TSR1 METTL16 GC17M002372
GH17F002390 0.8 FANTOM5 ENCODE 18.5 +2.1 2107 18.6 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 METTL16 SMYD4 ENSG00000263345 SMG6 MNT EIF4A1P9 SAMD11P1 ENSG00000262869 OR1E3 OR1D2
GH17F002357 1.2 Ensembl ENCODE 16.8 +41.9 41862 2.8 TBP PKNOX1 INSM2 ZNF76 KLF17 GLIS2 ZNF366 SCRT2 FOS SMARCC1 SGSM2 MNT TSR1 SNORD91A SNORD91B SMG6 SRR HIC1 OVCA2 METTL16
GH17F002369 0.2 ENCODE 16.7 +31.1 31142 1.3 CTCF ZNF692 SCRT2 ZBTB40 RAD21 MNT SGSM2 TSR1 SNORD91A SNORD91B ENSG00000263345 LOC101927864 GC17M002359
GH17F002481 1.3 FANTOM5 Ensembl ENCODE 11.1 -81.3 -81251 1.0 SCRT1 NFIA SCRT2 NR2F6 RARA METTL16 MNT SMG6 RAP1GAP2 GC17M002465 GC17M002467 GC17P002507 ENSG00000280280
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MNT on UCSC Golden Path with GeneCards custom track

Promoters for MNT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001339073 418 3801 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for MNT Gene

Chromosome:
17
Start:
2,384,060 bp from pter
End:
2,401,118 bp from pter
Size:
17,059 bases
Orientation:
Minus strand

Genomic View for MNT Gene

Genes around MNT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MNT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MNT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MNT Gene

Proteins for MNT Gene

  • Protein details for MNT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99583-MNT_HUMAN
    Recommended name:
    Max-binding protein MNT
    Protein Accession:
    Q99583
    Secondary Accessions:
    • A8K6D1
    • D3DTI7
    • Q1ED38

    Protein attributes for MNT Gene

    Size:
    582 amino acids
    Molecular mass:
    62300 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.

neXtProt entry for MNT Gene

Post-translational modifications for MNT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MNT Gene

No data available for DME Specific Peptides for MNT Gene

Domains & Families for MNT Gene

Protein Domains for MNT Gene

Suggested Antigen Peptide Sequences for MNT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99583

UniProtKB/Swiss-Prot:

MNT_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MNT: view

Function for MNT Gene

Molecular function for MNT Gene

GENATLAS Biochemistry:
Max interactor 2 (interacting with Max to bind Myc-Max recognition sites),MYC family acting as a transcriptional repressor in an E.box driver reporter gene repression system through interaction between the N-terminus and SIN3 corepressor,potentially involved in proliferation and differentiation,not involved in lung cancer
UniProtKB/Swiss-Prot Function:
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5-CACGTG-3 and, with higher affinity, to 5-CACGCG-3.

Gene Ontology (GO) - Molecular Function for MNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 9184233
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 9184233
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9184233
genes like me logo Genes that share ontologies with MNT: view
genes like me logo Genes that share phenotypes with MNT: view

Animal Models for MNT Gene

MGI Knock Outs for MNT:

Animal Model Products

miRNA for MNT Gene

miRTarBase miRNAs that target MNT

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MNT Gene

Localization for MNT Gene

Subcellular locations from UniProtKB/Swiss-Prot for MNT Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MNT Gene COMPARTMENTS Subcellular localization image for MNT gene
Compartment Confidence
nucleus 5
cytosol 2
endosome 1
extracellular 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with MNT: view

Pathways & Interactions for MNT Gene

SuperPathways for MNT Gene

No Data Available

Gene Ontology (GO) - Biological Process for MNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 9184233
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9184233
GO:0007275 multicellular organism development TAS 9184233
genes like me logo Genes that share ontologies with MNT: view

No data available for Pathways by source and SIGNOR curated interactions for MNT Gene

Drugs & Compounds for MNT Gene

(1) Drugs for MNT Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MNT: view

Transcripts for MNT Gene

Unigene Clusters for MNT Gene

MNT, MAX dimerization protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MNT Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - - - -
SP2: - -
SP3: - -
SP4:
SP5: - - - - - - - - - - -
SP6: -
SP7:

Relevant External Links for MNT Gene

GeneLoc Exon Structure for
MNT
ECgene alternative splicing isoforms for
MNT

Expression for MNT Gene

mRNA expression in normal human tissues for MNT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MNT Gene

This gene is overexpressed in Esophagus (41.8) and Lymph node (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MNT Gene



Protein tissue co-expression partners for MNT Gene

NURSA nuclear receptor signaling pathways regulating expression of MNT Gene:

MNT

SOURCE GeneReport for Unigene cluster for MNT Gene:

Hs.632239
genes like me logo Genes that share expression patterns with MNT: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MNT Gene

Orthologs for MNT Gene

This gene was present in the common ancestor of animals.

Orthologs for MNT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MNT 34 35
  • 98.91 (n)
mouse
(Mus musculus)
Mammalia Mnt 34 16 35
  • 89.86 (n)
dog
(Canis familiaris)
Mammalia MNT 34 35
  • 89.24 (n)
cow
(Bos Taurus)
Mammalia MNT 34 35
  • 89.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MNT 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MNT 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves MNT 34 35
  • 69.16 (n)
lizard
(Anolis carolinensis)
Reptilia MNT 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mnt 34
  • 64.42 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10853 34
zebrafish
(Danio rerio)
Actinopterygii mntb 35
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mnt 35
  • 16 (a)
OneToOne
Species where no ortholog for MNT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MNT Gene

ENSEMBL:
Gene Tree for MNT (if available)
TreeFam:
Gene Tree for MNT (if available)

Paralogs for MNT Gene

No data available for Paralogs for MNT Gene

Variants for MNT Gene

Sequence variations from dbSNP and Humsavar for MNT Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111531212 -- 2,395,833(+) GGGTC(A/G)GGGGA intron-variant
rs111598790 -- 2,390,451(+) GGACA(C/T)TTGGT intron-variant, utr-variant-5-prime
rs111756272 -- 2,396,121(+) GCCCC(-/C)ACGTC intron-variant
rs111801969 -- 2,393,828(+) GCGCG(C/G)GAGGG intron-variant
rs111894434 -- 2,392,796(+) GCGAG(A/C)CCGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MNT Gene

Variant ID Type Subtype PubMed ID
dgv3083n100 CNV gain 25217958
nsv1055225 CNV loss 25217958
nsv1063109 CNV gain 25217958
nsv1066475 CNV loss 25217958
nsv1070377 CNV deletion 25765185
nsv1160443 CNV deletion 26073780
nsv1160444 CNV deletion 26073780
nsv1160445 CNV duplication 26073780
nsv469765 CNV loss 16826518
nsv470569 CNV loss 18288195
nsv517489 CNV loss 19592680
nsv574224 CNV gain 21841781
nsv833336 CNV loss 17160897
nsv833338 CNV loss 17160897
nsv952104 CNV deletion 24416366

Variation tolerance for MNT Gene

Residual Variation Intolerance Score: 9.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.80; 58.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MNT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MNT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MNT Gene

Disorders for MNT Gene

Relevant External Links for MNT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MNT

No disorders were found for MNT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MNT Gene

Publications for MNT Gene

  1. The human ROX gene: genomic structure and mutation analysis in human breast tumors. (PMID: 9598315) Nigro C.L. … Carrozzo R. (Genomics 1998) 2 3 4 64
  2. Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes. (PMID: 19086036) Yang H. … Lu S.C. (Hepatology 2009) 3 22 64
  3. Mnt takes control as key regulator of the myc/max/mxd network. (PMID: 17419941) WahlstrAPm T. … Henriksson M. (Adv. Cancer Res. 2007) 3 22 64
  4. Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia. (PMID: 17577784) Guo X.L. … Ohno R. (Leuk. Lymphoma 2007) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for MNT Gene

Sources for MNT Gene

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