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Aliases for MNS1 Gene

Aliases for MNS1 Gene

  • Meiosis-Specific Nuclear Structural 1 2 3
  • Spermatogenesis Associated 40 2 3
  • Meiosis-Specific Nuclear Structural Protein 1 3
  • FLJ11222 6
  • SPATA40 3

External Ids for MNS1 Gene

Summaries for MNS1 Gene

Entrez Gene Summary for MNS1 Gene

  • This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. [provided by RefSeq, Oct 2008]

GeneCards Summary for MNS1 Gene

MNS1 (Meiosis-Specific Nuclear Structural 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for MNS1 Gene

  • May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MNS1 Gene

Genomics for MNS1 Gene

Genomic Location for MNS1 Gene

56,421,544 bp from pter
56,465,137 bp from pter
43,594 bases
Minus strand

Genomic View for MNS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MNS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MNS1 Gene

Regulatory Elements for MNS1 Gene

Proteins for MNS1 Gene

  • Protein details for MNS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Meiosis-specific nuclear structural protein 1
    Protein Accession:
    Secondary Accessions:
    • Q8IYT6
    • Q9NUP4

    Protein attributes for MNS1 Gene

    495 amino acids
    Molecular mass:
    60571 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MNS1 Gene

Proteomics data for MNS1 Gene at MOPED

Post-translational modifications for MNS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MNS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MNS1 Gene

Domains for MNS1 Gene

Protein Domains for MNS1 Gene



  • Belongs to the MNS1 family.:
    • Q8NEH6
genes like me logo Genes that share domains with MNS1: view

No data available for Gene Families for MNS1 Gene

Function for MNS1 Gene

Molecular function for MNS1 Gene

UniProtKB/Swiss-Prot Function: May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis.

Gene Ontology (GO) - Molecular Function for MNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IDA 22396656
genes like me logo Genes that share ontologies with MNS1: view
genes like me logo Genes that share phenotypes with MNS1: view

Animal Models for MNS1 Gene

MGI Knock Outs for MNS1:

miRNA for MNS1 Gene

miRTarBase miRNAs that target MNS1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MNS1 Gene

Localization for MNS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MNS1 Gene

Subcellular locations from

Jensen Localization Image for MNS1 Gene COMPARTMENTS Subcellular localization image for MNS1 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA --
GO:0005882 intermediate filament IEA --
GO:0005930 axoneme IEA --
GO:0036126 sperm flagellum IEA --
genes like me logo Genes that share ontologies with MNS1: view

Pathways for MNS1 Gene

SuperPathways for MNS1 Gene

No Data Available

Interacting Proteins for MNS1 Gene

Selected Interacting proteins: Q8NEH6-MNS1_HUMAN for MNS1 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for MNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044782 cilium organization IEA --
GO:0051321 meiotic cell cycle IEA --
GO:0070986 left/right axis specification IEA --
genes like me logo Genes that share ontologies with MNS1: view

No data available for Pathways by source for MNS1 Gene

Transcripts for MNS1 Gene

mRNA/cDNA for MNS1 Gene

Unigene Clusters for MNS1 Gene

Meiosis-specific nuclear structural 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MNS1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP4: -

Relevant External Links for MNS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MNS1 Gene

mRNA expression in normal human tissues for MNS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MNS1 Gene

This gene is overexpressed in Testis (12.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MNS1 Gene

SOURCE GeneReport for Unigene cluster for MNS1 Gene Hs.444483

genes like me logo Genes that share expressions with MNS1: view

Orthologs for MNS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MNS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MNS1 36
  • 99.66 (n)
  • 99.6 (a)
MNS1 37
  • 100 (a)
(Bos Taurus)
Mammalia MNS1 36
  • 88.71 (n)
  • 87.22 (a)
MNS1 37
  • 88 (a)
(Canis familiaris)
Mammalia MNS1 36
  • 89.63 (n)
  • 89.9 (a)
MNS1 37
  • 90 (a)
(Mus musculus)
Mammalia Mns1 36
  • 76.1 (n)
  • 77.39 (a)
Mns1 16
Mns1 37
  • 77 (a)
(Monodelphis domestica)
Mammalia MNS1 37
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia MNS1 37
  • 64 (a)
(Rattus norvegicus)
Mammalia Mns1 36
  • 76.36 (n)
  • 77.37 (a)
(Gallus gallus)
Aves LOC426295 36
  • 70 (n)
  • 65.71 (a)
MNS1 37
  • 50 (a)
(Anolis carolinensis)
Reptilia MNS1 37
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mns1 36
  • 65.71 (n)
  • 59.26 (a)
Str.7024 36
(Danio rerio)
Actinopterygii mns1 36
  • 59.77 (n)
  • 54.77 (a)
mns1 37
  • 50 (a)
sbcb494 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004208 36
  • 50 (n)
  • 36.21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2336 36
Species with no ortholog for MNS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MNS1 Gene

Gene Tree for MNS1 (if available)
Gene Tree for MNS1 (if available)

Paralogs for MNS1 Gene

No data available for Paralogs for MNS1 Gene

Variants for MNS1 Gene

Sequence variations from dbSNP and Humsavar for MNS1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs768960 -- 56,447,635(-) aaata(C/T)attca intron-variant
rs795773 -- 56,462,017(-) ccccc(A/C)cccca intron-variant
rs795774 -- 56,462,000(-) aaaaa(A/C)aaaaa intron-variant
rs795775 -- 56,461,994(-) aaaaa(A/C)aaaaa intron-variant
rs795776 -- 56,461,985(-) aaaaa(A/C)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MNS1 Gene

Variant ID Type Subtype PubMed ID
nsv1545 CNV Loss 18451855
dgv10n31 CNV Deletion 19718026
nsv904246 CNV Loss 21882294
nsv498847 CNV Loss 21111241
esv2525559 CNV Loss 19546169
nsv433294 CNV Loss 18776910
esv35150 CNV Loss 17911159
nsv510662 CNV Loss 20534489
nsv9270 CNV Loss 18304495
dgv749e1 CNV Complex 17122850

Relevant External Links for MNS1 Gene

HapMap Linkage Disequilibrium report

Disorders for MNS1 Gene

(1) University of Copenhagen DISEASES for MNS1 Gene

Relevant External Links for MNS1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with MNS1: view

No data available for UniProtKB/Swiss-Prot for MNS1 Gene

Publications for MNS1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Meiosis specific transcription and functional proteins. (PMID: 7625268) Hotta Y. … Tabata S. (Adv. Biophys. 1995) 2 3
  3. cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association. (PMID: 8032679) Furukawa K. … Hotta Y. (Chromosome Res. 1994) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. (PMID: 15942958) Shakib K. … Godovac-Zimmermann J. (Proteomics 2005) 3

Products for MNS1 Gene

Sources for MNS1 Gene

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