MNS1 Gene
protein-coding GIFtS : 48
GCID: GC15 M056720
meiosis-specific nuclear structural 1
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Aliasesfor MNS1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Meiosis-Specific Nuclear Structural 1 1 2 SPATA401 2 FLJ112221 5 Meiosis-Specific Nuclear Structural Protein 12 Spermatogenesis Associated 402
Export aliases for MNS1 gene to outside databases Previous GC identifers: GC15M054300 GC15M054437 GC15M054508 GC15M033544
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Summariesfor MNS1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MNS1 : This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. (provided by RefSeq, Oct 2008) UniProtKB/Swiss-Prot: MNS1_HUMAN, Q8NEH6 Function : May play a role in the control of meiotic division and germ cell differentiation through regulation ofpairing and recombination during meiosis (By similarity)
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Genomic Viewsfor MNS1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010194.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MNS1 gene promoter: MEF-2A POU2F1 oct-B3 oct-B2 POU2F1a Cart-1 CUTL1 aMEF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for MNS1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MNS1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q21.3 Ensembl cytogenetic band: 15q21.3 HGNC cytogenetic band: 15q21.3 MNS1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15M056720: view genomic region
(about GC identifiers )
Start:
56,713,742 bp from pter
End:
56,757,335 bp from pter
Size:
43,594 bases
Orientation:
minus strand
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Proteinsfor MNS1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MNS1_HUMAN, Q8NEH6 (See
protein sequence )Recommended Name: Meiosis-specific nuclear structural protein 1 Size : 495 amino acids; 60571 Da
Subcellular location : Nucleus (By similarity)
Secondary accessions : Q8IYT6 Q9NUP4Explore the universe of human proteins at neXtProt for MNS1: NX_Q8NEH6 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8NEH6 MNS1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_060835.1 ENSEMBL proteins: ENSP00000260453 Human Recombinant Protein Products for MNS1: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005635 nuclear envelope
IEA -- GO:0005882 intermediate filament
IEA --
MNS1 for ontologies About GeneDecksing MNS1 Antibody Products: Assay Products for MNS1:
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Protein
Domains / Familiesfor MNS1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MNS1 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q8NEH6 ProtoNet protein and cluster: Q8NEH6
UniProtKB/Swiss-Prot: MNS1_HUMAN, Q8NEH6 Similarity : Belongs to the MNS1 family
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Functionfor MNS1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: MNS1_HUMAN, Q8NEH6 Function : May play a role in the control of meiotic division and germ cell differentiation through regulation ofpairing and recombination during meiosis (By similarity) Phenotypes: 6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mns1) :
MNS1 for phenotypes About GeneDecksing Animal Models: Mouse knock-out Mns1 tm1Jw for MNS1Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MNS1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MNS1OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MNS1 (NM_018365 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MNS1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MNS1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MNS1
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Pathways & Interactionsfor MNS1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MNS1 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)5 Interacting proteins for MNS1 (Q8NEH6 2 , 3 ENSP00000260453 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007126 meiosis
IEA --
MNS1 for ontologies About GeneDecksing
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Drugs & Compoundsfor MNS1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MNS1 Search CenterWatch for drugs/clinical trials and news about MNS1
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Transcriptsfor MNS1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MNS1 gene: NM_018365.2 Unigene Cluster for MNS1:
Meiosis-specific nuclear structural 1 Hs.444483 [show with all ESTs ] Unigene Representative Sequence: NM_018365 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000566386 ENST00000260453 (uc010bfo.2 uc002adr.2 ) ENST00000558694 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MNS1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MNS1OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MNS1 (NM_018365 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MNS1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MNS1
Additional cDNA sequence: AK002084.1 AK057542.1 BC012554.1 BC031046.1 BC034991.2
7 DOTS entries : DT.104221 DT.95106656
DT.100000813 DT.121055886 DT.40203956 DT.75134216 DT.92005376 24/63 AceView cDNA sequences (see all 63 ):
BM723258 BQ690909 BM718474 AI263135 BX332829 AU138250 BM453670 BE463733 AL570577 AI351245 BI522557 BU853637 BC031046 BM682262 AI911786 AA782916 BQ685758 BG029529 AK002084 BI825252 BE221805 BU934031 BU075701 AI829741 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for MNS1 About this scheme ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 SP1 :                             SP2 :                             SP3 :                             SP4 :         -                    
ECgene alternative splicing isoforms for MNS1
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Expression for MNS1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MNS1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTACAAACTTAbout this image MNS1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ progenitor F15 (Embryonic Progenitor Cell)Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See MNS1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MNS1 SOURCE GeneReport for Unigene cluster: Hs.444483 SABiosciences Custom PCR Arrays for MNS1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MNS1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MNS1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MNS1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MNS1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MNS1
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Orthologsfor MNS1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for MNS1 gene from 6/21 species (see all 21 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
LOC4262951
meiosis-specific nuclear structural protein 1-like
68.25(n) 63.49(a)
 
426295 XM_423957.3 XP_423957.3
lizard (Anolis carolinensis)
Reptilia
MNS16
--
62(a)
1 ↔ 1
GL343573.1(455407-458724)
tropical clawed frog (Xenopus tropicalis)
Amphibia
Str.70242
Transcribed sequence with weak similarity to protein more
76.2(n)
 
BX740292.1
zebrafish (Danio rerio)
Actinopterygii
sbcb4942
sbcb494
72.08(n)
 
368341 NM_199433.1
mosquito (Anopheles gambiae)
Insecta
AgaP_AGAP0042081
AGAP004208-PA
47.23(n) 32.79(a)
 
1274046 XM_313110.4 XP_313110.4
worm (Caenorhabditis elegans)
Secernentea
ajm-16
Apical Junction Molecule family member (ajm-1)
3(a)
possible ortholog
X(9098290-9113562)
ENSEMBL Gene Tree for MNS1 (if available)TreeFam Gene Tree for MNS1 (if available)
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Paralogsfor MNS1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MNS1 gene CCDC11 2 CCDC173 2 CCDC19 2 TCHP 2
MNS1 for paralogs About GeneDecksing
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Genomic Variantsfor MNS1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 15 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MNS1 (56713742 - 56757335 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 10 variations for MNS1 10 CNVs : 102107 76972 9265 76971 35323 32038 87689 87690 3083 37526
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MNS1
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Disorders
/ Diseasesfor MNS1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MNS1 for disorders About GeneDecksing
OMIM gene information: 610766
OMIM disorders : --3 diseases for MNS1 : About MalaCards situs inversus hypoxia malaria 1 disease from the University of Copenhagen DISEASES database for MNS1 :Situs inversus Export disorders for MNS1 gene to outside databases
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Publicationsfor MNS1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MNS1 gene integrated from 9 sources : (articles sorted by number of sources associating them with MNS1) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Meiosis specific transcription and functional proteins. (PubMed id 7625268) 1 , 3 Hotta Y....Tabata S. (1995) cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association. (PubMed id 8032679) 1 , 3 Furukawa K....Hotta Y. (1994) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 1 Rual J.F....Vidal M. (2005) Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. (PubMed id 15942958) 1 Shakib K....Godovac-Zimmermann J. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for MNS1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MNS1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MNS1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing MNS1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MNS1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MNS1 gene: Search GeneIP for patents involving MNS1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MNS1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MNS1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MNS1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MNS1 OriGene Protein Over-expression Lysate for MNS1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MNS1 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MNS1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MNS1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MNS1 OriGene Custom Protein Services for MNS1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MNS1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MNS1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MNS1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MNS1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MNS1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MNS1
Search Tocris compounds for MNS1
MNS1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MNS1
ThermoFisher Antibodies for MNS1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MNS1
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Aliases for MNS1
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Disorders / Diseases for MNS1
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Drugs / Compounds for MNS1
Expression for MNS1
Function for MNS1
Genomic Views for MNS1
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Pathways / Interactions for MNS1
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