MNF1 Gene
protein-coding GIFtS: 38
GCID: GC06M033666
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|
mitochondrial nucleoid factor 1(Previous name: chromosome 6 open reading frame 125 )
(Previous symbol: C6orf125)
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Aliases
for MNF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Nucleoid Factor 11 2 | | Mitochondrial Protein M192 3 | | C6orf1251 2 3 | | MGC148331 | | Cbp61 2 | | Chromosome 6 Open Reading Frame 1251 | | M191 2 | | Breast Cancer Associated Protein SGA-81M2 | | BA6B20.21 | | Cytochrome B Protein Synthesis 6 Homolog2 | | Breast Cancer-Associated Protein SGA-81M2 3 | | |
Export aliases for MNF1 gene to outside databases |
Summaries
for MNF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MNF1:
This gene encodes a nucleoid protein localized to the mitochondria inner membrane. The encoded protein affectsregulation of insulin secretion, mitochondrial ATP production, and myogenesis through modulation of mitochondrialrespiratory chain activity. (provided by RefSeq, Oct 2012)
|
Genomic Views
for MNF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MNF1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MNF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MNF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.31 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.31MNF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M033666: view genomic region
(about GC identifiers)
Start:
|
33,665,345 bp from pter |
End:
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33,679,504 bp from pter |
Size:
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14,160 bases |
Orientation:
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minus strand |
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Proteins
for MNF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MNF1_HUMAN, Q9BRT2 (See
protein sequence)Recommended Name: Mitochondrial nucleoid factor 1 Size: 126 amino acids; 14875 Da
Subcellular location: Mitochondrion matrix, mitochondrion nucleoid
Secondary accessions: B2R4I0Explore the universe of human proteins at neXtProt for MNF1: NX_Q9BRT2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BRT2
MNF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115716.1
ENSEMBL proteins: ENSP00000363348 ENSP00000363331
Human Recombinant Protein Products for MNF1:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MNF1 for ontologies About GeneDecksing
MNF1 Antibody Products:
Assay Products for MNF1: |
Protein
Domains /
Families
for MNF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9BRT2 |
Function
for MNF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MNF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MNF1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for MNF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MNF1 |
|
Pathways & Interactions
for MNF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MNF1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for MNF1 (Q9BRT23 ENSP000003633484) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for MNF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MNF1
Search CenterWatch for drugs/clinical trials and news about MNF1
|
Transcripts
for MNF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MNF1 gene: NM_032340.3 Unigene Cluster for MNF1: Mitochondrial nucleoid factor 1 Hs.93235 [show with all ESTs]Unigene Representative Sequence: AK1274682 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374231(uc003ofa.1 uc010jve.1) ENST00000374214
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MNF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MNF1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for MNF1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MNF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MNF1 |
Additional cDNA sequence: AF086234.1 AK127468.1 AK311835.1 AY281252.1 AY568085.1 BC006007.1 BC033214.1 13 DOTS entries: DT.100035859 DT.115525 DT.113101 DT.100784155 DT.100813759 DT.86846143 DT.40118454 DT.121314891 DT.40107112 DT.91656031 DT.121314943 DT.317607 DT.40257778 24/109 AceView cDNA sequences (see all 109): BM708842 AF086234 BE907725 BM699872 AI598252 BQ441152 AA321626 AI734878 F36633 AA933045 F32178 AI563924 BQ897039 NM_032340 BE936758 AA372713 AI239551 AA314199 BI522811 BG181737 AI871374 AA296006 AY568085 AI583241
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for MNF1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b |
|---|
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| SP1: | | | | | - | | - | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MNF1
|
Expression
for MNF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MNF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGAAGAAAC
About this image
See MNF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MNF1
SOURCE GeneReport for Unigene cluster: Hs.93235
SABiosciences Custom PCR Arrays for MNF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MNF1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MNF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MNF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MNF1 |
Orthologs
for MNF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MNF1 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mnf11 , 5 |
RIKEN cDNA 2900010M23 gene5
mitochondrial nucleoid factor 11 |
90.48(n)1
91.27(a)1 |
|
17 (13.75 cM)5
672671 NM_026063.21 NP_080339.11
271226635 |
chicken
(Gallus gallus) |
Aves |
MNF11 |
mitochondrial nucleoid factor 1 |
72.8(n)
67.2(a) |
|
419909 XM_418034.3 XP_418034.2 |
lizard
(Anolis carolinensis) |
Reptilia |
C6orf1256 |
-- |
71(a) |
1 ↔ 1 |
4(123028912-123038383) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.64612 |
Xenopus laevis transcribed sequence with weak similarity more |
76.47(n) |
|
AW633544.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.178652 |
Transcribed sequence with moderate similarity to protein more |
76.5(n) |
|
AL722150.1 |
ENSEMBL Gene Tree for MNF1 (if available)
TreeFam Gene Tree for MNF1 (if available) |
Paralogs
for MNF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MNF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MNF1 (33665345 - 33679504 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MNF1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MNF1 |
|
Disorders
/ Diseases
for MNF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MNF1 for disorders About GeneDecksing
OMIM gene information: 614461
OMIM disorders: --
3  diseases for MNF1: About MalaCardsbreast cancer systemic lupus erythematosus lupus erythematosus
Export disorders for MNF1 gene to outside databases
|
Publications
for MNF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MNF1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with MNF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Association of a novel mitochondrial protein M19 with mitochondrial nucleoids. (PubMed id 19643811)1, 2 Sumitani M....Endo H. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- M19 modulates skeletal muscle differentiation and insu lin secretion in pancreatic b-cells through modulation of respiratory chain acti vity. (PubMed id 22363741)1 Cambier L....Pomies P. (2012)
- Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing. (PubMed id 22277967)1 Calvo S.E.... Mootha V.K. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for MNF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MNF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MNF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MNF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MNF1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MNF1 gene:
Search GeneIP for patents involving MNF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MNF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MNF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MNF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MNF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MNF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MNF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MNF1 |
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| | | | Search Tocris compounds for MNF1 |
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 | | | MNF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for MNF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MNF1 |
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