External Ids for MNDA Gene
Previous GeneCards Identifiers for MNDA Gene
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]
GeneCards Summary for MNDA Gene
MNDA (Myeloid Cell Nuclear Differentiation Antigen) is a Protein Coding gene. Diseases associated with MNDA include Diffuse Scleroderma and Limited Scleroderma. Among its related pathways are Innate Immune System and NF-kappaB Signaling. An important paralog of this gene is PYHIN1.
UniProtKB/Swiss-Prot for MNDA Gene
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.