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MNDA Gene

protein-coding   GIFtS: 58
GCID: GC01P158801

Myeloid Cell Nuclear Differentiation Antigen

  See MNDA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Myeloid Cell Nuclear Differentiation Antigen1 2
PYHIN32

External Ids:    HGNC: 71831   Entrez Gene: 43322   Ensembl: ENSG000001635637   OMIM: 1595535   UniProtKB: P412183   

Export aliases for MNDA gene to outside databases

Previous GC identifers: GC01P156593 GC01P154533 GC01P155579 GC01P156017 GC01P155614 GC01P157067 GC01P130158


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MNDA Gene:
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the
granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the
proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that
are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an
interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human
monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its
pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood
cell-specific responses to interferons. (provided by RefSeq, Jul 2008)

GeneCards Summary for MNDA Gene:
MNDA (myeloid cell nuclear differentiation antigen) is a protein-coding gene. Diseases associated with MNDA include myelodysplastic syndromes. An important paralog of this gene is AIM2.

UniProtKB/Swiss-Prot: MNDA_HUMAN, P41218
Function: May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the
granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional
repressor protein YY1

Gene Wiki entry for MNDA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the MNDA gene promoter:
         S8   FOXJ2 (long isoform)   ATF-2   Chx10   Cart-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMNDA promoter sequence
   Search Chromatin IP Primers for MNDA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MNDA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q22

MNDA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MNDA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P158801:  view genomic region     (about GC identifiers)

Start:
158,801,107 bp from pter      End:
158,819,296 bp from pter
Size:
18,190 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MNDA_HUMAN, P41218 (See protein sequence)
Recommended Name: Myeloid cell nuclear differentiation antigen  
Size: 407 amino acids; 45836 Da
Subunit: Participates in a ternary complex with YY1 and the YY1 target DNA element. Binds nucleolin and
nucleophosmin/NPM/B23
1 PDB 3D structure from and Proteopedia for MNDA:
2DBG (3D)    

Explore the universe of human proteins at neXtProt for MNDA: NX_P41218

Explore proteomics data for MNDA at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MNDA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002423.1  
    ENSEMBL proteins: 
     ENSP00000357123   ENSP00000406800  

    MNDA Human Recombinant Protein Products:

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    OriGene MassSpec for MNDA
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    Novus Biologicals MNDA Proteins
    Novus Biologicals MNDA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MNDA
    Cloud-Clone Corp. Proteins for MNDA

     
    Search eBioscience for Proteins for MNDA 

    MNDA Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MNDA 
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    Novus Biologicals MNDA Antibodies
    Abcam antibodies for MNDA
    Cloud-Clone Corp. Antibodies for MNDA
    ThermoFisher Antibodies for MNDA
    LSBio Antibodies in human, mouse, rat for MNDA

    MNDA Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MNDA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MNDA
    Cloud-Clone Corp. CLIAs for MNDA
    Search eBioscience for ELISAs for MNDA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR004021 HIN200/IF120x
     IPR012340 NA-bd_OB-fold
     IPR004020 DAPIN

    Graphical View of Domain Structure for InterPro Entry P41218

    ProtoNet protein and cluster: P41218

    1 Blocks protein domain: IPB004021 HIN-200/IF120x domain

    UniProtKB/Swiss-Prot: MNDA_HUMAN, P41218
    Domain: Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a
    portion of this sequence is responsible for binding YY1
    Similarity: Contains 1 DAPIN domain
    Similarity: Contains 1 HIN-200 domain


    Find genes that share domains with MNDA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MNDA_HUMAN, P41218
    Function: May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the
    granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional
    repressor protein YY1
    Induction: Strongly induced by alpha interferon which selectively affects expression in late stage cells in the
    monocytic but not the granulocytic lineage. Induced in vitro by dimethylsulfoxide and 1,25 dihydroxyvitamin D3

         Genatlas biochemistry entry for MNDA:
    myeloid nuclear differentiation antigen,interferon alpha-inducible protein

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with MNDA           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MNDA:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MNDA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MNDA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MNDA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MNDA

    miRNA
    Products:
        
    miRTarBase miRNAs that target MNDA:
    hsa-mir-26b-5p (MIRT029540)

    Block miRNA regulation of human, mouse, rat MNDA using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MNDA
    SwitchGear 3'UTR luciferase reporter plasmidMNDA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MNDA
    Predesigned siRNA for gene silencing in human, mouse, rat MNDA

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MNDA

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MNDA (NM_002432)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MNDA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MNDA

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MNDA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MNDA_HUMAN, P41218: Nucleus. Cytoplasm. Note=Uniformly distributed throughout the interphase cell nucleus.
    Associates with chromatin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0043231intracellular membrane-bounded organelle ----
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with MNDA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MNDA About    
    See pathways by source

    SuperPathContained pathways About
    1Lymphocyte Signaling
    Lymphocyte Signaling
    2Apoptosis and Autophagy
    Apoptosis and Autophagy


    Find genes that share SuperPaths with MNDA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for MNDA
        Apoptosis and Autophagy
    Lymphocyte Signaling


        Pathway & Disease-focused RT2 Profiler PCR Arrays including MNDA: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MNDA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for MNDA (P412181, 2, 3 ENSP000003571234) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK2P249413, ENSP000002669704I2D: score=2 STRING: ENSP00000266970
    RBL2Q089993, ENSP000002621334I2D: score=2 STRING: ENSP00000262133
    TP53P046373, ENSP000002693054I2D: score=2 STRING: ENSP00000269305
    RB1P064003, ENSP000002671634I2D: score=2 STRING: ENSP00000267163
    HOXB2P146523, ENSP000003317414I2D: score=2 STRING: ENSP00000331741
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006968cellular defense response TAS1644857
    GO:0006974cellular response to DNA damage stimulus IMP17875758
    GO:0030889negative regulation of B cell proliferation IMP17875758

    Find genes that share ontologies with MNDA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MNDA

    5 Novoseek inferred chemical compound relationships for MNDA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mnda 99.6 217 15778972 (12), 7890814 (11), 10492038 (9), 8175894 (9) (see all 38)
    p202 93.9 3 17981573 (1), 9642285 (1)
    physostigmine 70 4 11215814 (1), 17981573 (1), 9642285 (1)
    endotoxin 13.2 2 7890814 (1), 8175894 (1)
    lipid 0 1 15778972 (1)



    Find genes that share compounds with MNDA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MNDA gene: 
    NM_002432.1  

    Unigene Cluster for MNDA:

    Myeloid cell nuclear differentiation antigen
    Hs.153837  [show with all ESTs]
    Unigene Representative Sequence: BC032319
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368141(uc001fsz.1) ENST00000491210 ENST00000438394
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMNDA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MNDA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MNDA (NM_002432)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MNDA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MNDA
    Primer
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    OriGene qPCR primer pairs and template standards for MNDA
    OriGene qSTAR qPCR primer pairs in human, mouse for MNDA
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MNDA
      QuantiTect SYBR Green Assays in human, mouse, rat MNDA
      QuantiFast Probe-based Assays in human, mouse, rat MNDA

    Additional mRNA sequence: 

    AK290392.1 AK313210.1 BC020715.1 BC032319.1 M81750.1 

    6 DOTS entries:

    DT.101986484  DT.210891  DT.95265764  DT.95265765  DT.100709149  DT.92426782 

    Selected AceView cDNA sequences (see all 57):

    AV715791 BX952054 AV718301 AU135562 BI821232 BC020715 BC032319 CA412436 
    AU140092 BG506590 BX366163 NM_002432 BP432041 AV714775 BX111714 M81750 
    AV717567 R77431 N47924 AV715357 BI760503 AV713616 BG540480 BM903669 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MNDA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGTAGTGG
    MNDA Expression
    About this image


    MNDA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Monocytes Peripheral Blood
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Spleen (Hematopoietic System)
    MNDA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MNDA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.153837

    UniProtKB/Swiss-Prot: MNDA_HUMAN, P41218
    Tissue specificity: Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as
    well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast
    cells in some cases of acute myeloid Leukemia

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MNDA: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat MNDA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MNDA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for MNDA (if available)
    TreeFam Gene Tree for MNDA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MNDA gene
    AIM22  IFI162  PYHIN12  
    3 SIMAP similar genes for MNDA using alignment to 4 protein entries:     MNDA_HUMAN (see all proteins):
    PYHIN1    IFI16    AIM2

    Find genes that share paralogs with MNDA           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MNDA
    PGOHUM00000245030


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MNDA (see all 465)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1178355441,2
    C,F--158799193(+) TCAAAC/TTCTAA 1 -- us2k11Minor allele frequency- T:0.12EA 120
    rs1461211441,2
    C--158799215(+) CTAGGC/TCAGGG 1 -- us2k10--------
    rs1921147831,2
    --158799336(+) TTCTGC/TCACTA 1 -- us2k10--------
    rs66794121,2
    C--158799367(+) attcaA/Tcaagt 1 -- us2k10--------
    rs8577951,2
    C,F,A,H--158799391(-) gggaaC/Tgtttg 1 -- us2k15Minor allele frequency- T:0.25NA CSA 8
    rs120923471,2
    C--158799418(+) ttctgA/Cgcctt 1 -- us2k13Minor allele frequency- C:0.15NA EA 242
    rs66904461,2
    C,F,H--158799453(+) acccaG/Atttta 1 -- us2k110Minor allele frequency- A:0.08NS EA NA 1080
    rs66846291,2
    C,F--158799603(+) cttaaT/Cgttcc 1 -- us2k13Minor allele frequency- C:0.07WA NA EA 358
    rs1508945981,2
    --158799670(+) CTTACA/GTAGAT 1 -- us2k10--------
    rs23256981,2
    C,F,A,H--158799738(+) taaaaC/Tgatca 1 -- us2k1 tfbs310Minor allele frequency- T:0.08NS EA NA WA 766

    HapMap Linkage Disequilibrium report for MNDA (158801107 - 158819296 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MNDA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669506CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MNDA
    DNA2.0 Custom Variant and Variant Library Synthesis for MNDA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 159553    OMIM disorders: --

    1 disease for MNDA:    
    About MalaCards
    myelodysplastic syndromes


    Find genes that share disorders with MNDA           About GenesLikeMe

    10 Novoseek inferred disease relationships for MNDA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 37 2 2259228 (1), 8175894 (1)
    myelodysplastic syndromes 36.1 3 16651415 (2), 9328447 (1)
    burkitt lymphoma 34.7 1 11215814 (1)
    myeloid leukemia chronic 32.8 3 10492038 (1), 2259228 (1), 7890814 (1)
    melanoma 26.2 5 9642285 (1), 14757431 (1), 20187706 (1)
    lymphoma 24.3 8 19474799 (2), 10492038 (1), 7890814 (1)
    leukemia 23.2 2 2259228 (1), 7890814 (1)
    inflammation 16.4 5 15778972 (2), 10492038 (1), 16651415 (1)
    atherosclerosis 0 1 15778972 (1)
    tumors 0 2 1377701 (1), 18681780 (1)

    Genetic Association Database (GAD): MNDA
    Human Genome Epidemiology (HuGE) Navigator: MNDA (2 documents)

    Export disorders for MNDA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MNDA gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with MNDA)
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    1. Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha. (PubMed id 1644857)1, 2, 3, 9 Briggs J.A.... Briggs R.C. (J. Cell. Biochem. 1992)
    2. The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells. (PubMed id 7512843)1, 2, 3, 9 Briggs R.C.... Dessypris E.N. (Blood 1994)
    3. Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage. (PubMed id 8175894)1, 2, 9 Briggs R....Lian J. (J. Cell. Biochem. 1994)
    4. Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding. (PubMed id 9712147)1, 2, 9 Xie J.... Briggs R.C. (J. Cell. Biochem. 1998)
    5. Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins. (PubMed id 1377701)1, 2, 9 Burrus G.R.... Briggs R.C. (J. Cell. Biochem. 1992)
    6. The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression. (PubMed id 7806273)1, 2, 9 Dawson M.J....Baker E. (Immunogenetics 1995)
    7. Association of IFI200 gene polymorphisms with susceptibility to systemic lupus erythematosus. (PubMed id 20595294)1, 4 Kimkong I....Hirankarn N. (J. Rheumatol. 2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis. (PubMed id 15778972)1, 9 Briggs R.C....Miranda R.N. (J. Cell. Biochem. 2005)
    10. Identification of MNDA as a new marker for nodal marginal zone lymphoma. (PubMed id 19474799)1, 9 Kanellis G....Piris M.A. (Leukemia 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4332 HGNC: 7183 AceView: MNDA Ensembl:ENSG00000163563 euGenes: HUgn4332
    ECgene: MNDA H-InvDB: MNDA

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MNDA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MNDA gene:
    Search GeneIP for patents involving MNDA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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