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Aliases for MND1 Gene

Aliases for MND1 Gene

  • Meiotic Nuclear Divisions 1 Homolog (S. Cerevisiae) 2 3
  • GAJ 3 4
  • Meiotic Nuclear Division Protein 1 Homolog 3
  • Homolog Of Yeast MND1 3

External Ids for MND1 Gene

Previous GeneCards Identifiers for MND1 Gene

  • GC04P154485
  • GC04P154265
  • GC04P149996

Summaries for MND1 Gene

Entrez Gene Summary for MND1 Gene

  • The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]

GeneCards Summary for MND1 Gene

MND1 (Meiotic Nuclear Divisions 1 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with MND1 include developmental coordination disorder. Among its related pathways are Meiosis and Meiosis.

UniProtKB/Swiss-Prot for MND1 Gene

  • Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MND1 Gene

Genomics for MND1 Gene

Genomic Location for MND1 Gene

Start:
153,344,649 bp from pter
End:
153,415,118 bp from pter
Size:
70,470 bases
Orientation:
Plus strand

Genomic View for MND1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MND1 Gene

Proteins for MND1 Gene

  • Protein details for MND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWT6-MND1_HUMAN
    Recommended name:
    Meiotic nuclear division protein 1 homolog
    Protein Accession:
    Q9BWT6
    Secondary Accessions:
    • B2R5F9

    Protein attributes for MND1 Gene

    Size:
    205 amino acids
    Molecular mass:
    23753 Da
    Quaternary structure:
    • Heterodimer with PSMC3IP/HOP2. MND1-PSMC3IP interacts with DMC1 and RAD51 and binds preferentially to dsDNA.

neXtProt entry for MND1 Gene

Proteomics data for MND1 Gene at MOPED

Post-translational modifications for MND1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MND1 Gene

No data available for DME Specific Peptides for MND1 Gene

Domains for MND1 Gene

Protein Domains for MND1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BWT6

UniProtKB/Swiss-Prot:

MND1_HUMAN :
  • Q9BWT6
Family:
  • Belongs to the MND1 family.
genes like me logo Genes that share domains with MND1: view

No data available for Gene Families for MND1 Gene

Function for MND1 Gene

Molecular function for MND1 Gene

UniProtKB/Swiss-Prot Function: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.

Gene Ontology (GO) - Molecular Function for MND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MND1: view

Phenotypes for MND1 Gene

genes like me logo Genes that share phenotypes with MND1: view

miRNA for MND1 Gene

miRTarBase miRNAs that target MND1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MND1 Gene

Localization for MND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MND1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MND1 Gene COMPARTMENTS Subcellular localization image for MND1 gene
Compartment Confidence
nucleus 4
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MND1: view

Pathways for MND1 Gene

SuperPathways for MND1 Gene

Superpath Contained pathways
1 Meiosis
.74
genes like me logo Genes that share pathways with MND1: view

Pathways by source for MND1 Gene

2 Reactome pathways for MND1 Gene

Gene Ontology (GO) - Biological Process for MND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006310 DNA recombination IEA --
GO:0045892 negative regulation of transcription, DNA-templated --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with MND1: view

Transcripts for MND1 Gene

Unigene Clusters for MND1 Gene

Meiotic nuclear divisions 1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MND1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for MND1 Gene

GeneLoc Exon Structure for
MND1
ECgene alternative splicing isoforms for
MND1

Expression for MND1 Gene

mRNA expression in normal human tissues for MND1 Gene

mRNA differential expression in normal tissues according to GTEx for MND1 Gene

This gene is overexpressed in Testis (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MND1 Gene

SOURCE GeneReport for Unigene cluster for MND1 Gene Hs.294088

genes like me logo Genes that share expressions with MND1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MND1 Gene

Orthologs for MND1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MND1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MND1 35
  • 100 (n)
  • 100 (a)
MND1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MND1 35
  • 92.68 (n)
  • 92.2 (a)
MND1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MND1 35
  • 92.36 (n)
  • 93.17 (a)
MND1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mnd1 35
  • 86.02 (n)
  • 89.76 (a)
Mnd1 16
Mnd1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MND1 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mnd1 35
  • 84.55 (n)
  • 88.29 (a)
chicken
(Gallus gallus)
Aves MND1 35
  • 76.42 (n)
  • 77.56 (a)
MND1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MND1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mnd1 35
  • 72.03 (n)
  • 77.07 (a)
Str.15376 35
zebrafish
(Danio rerio)
Actinopterygii mnd1 35
  • 66.67 (n)
  • 71.43 (a)
mnd1 36
  • 59 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MND1 36
  • 26 (a)
OneToOne
MND1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ATMND1 35
  • 53.1 (n)
  • 44.61 (a)
rice
(Oryza sativa)
Liliopsida Os09g0280600 35
  • 51.72 (n)
  • 42.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mcp7 35
  • 50.34 (n)
  • 41.33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1758 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToOne
Species with no ortholog for MND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MND1 Gene

ENSEMBL:
Gene Tree for MND1 (if available)
TreeFam:
Gene Tree for MND1 (if available)

Paralogs for MND1 Gene

Pseudogenes.org Pseudogenes for MND1 Gene

genes like me logo Genes that share paralogs with MND1: view

No data available for Paralogs for MND1 Gene

Variants for MND1 Gene

Sequence variations from dbSNP and Humsavar for MND1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs717044 -- 153,378,117(+) GAATG(C/T)ATAAA intron-variant
rs950892 -- 153,395,917(-) AGATA(C/T)TCCAT intron-variant
rs951017 -- 153,396,648(-) ATCCA(A/G)TAAAA intron-variant
rs970120 -- 153,375,043(-) AACTT(G/T)TTCCA intron-variant
rs970121 -- 153,374,948(-) ATTTT(A/T)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MND1 Gene

Variant ID Type Subtype PubMed ID
nsv830118 CNV Loss 17160897
esv2666590 CNV Deletion 23128226
esv1507851 CNV Insertion 17803354

Relevant External Links for MND1 Gene

HapMap Linkage Disequilibrium report
MND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MND1 Gene

Disorders for MND1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MND1 Gene including...

Search for MND1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for MND1 Gene

Relevant External Links for MND1

Genetic Association Database (GAD)
MND1
Human Genome Epidemiology (HuGE) Navigator
MND1
genes like me logo Genes that share disorders with MND1: view

No data available for UniProtKB/Swiss-Prot for MND1 Gene

Publications for MND1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair. (PMID: 11940665) Tsubouchi H. … Roeder G.S. (Mol. Cell. Biol. 2002) 2 3
  3. Stimulation of DNA strand exchange by the human TBPIP/Hop2-Mnd1 complex. (PMID: 16407260) Enomoto R. … Yokoyama S. (J. Biol. Chem. 2006) 3 4
  4. Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase. (PMID: 17639080) Chi P. … Sung P. (Genes Dev. 2007) 3
  5. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3

Products for MND1 Gene

Sources for MND1 Gene

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