MND1 Gene
protein-coding GIFtS: 48
GCID: GC04P154265
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|
meiotic nuclear divisions 1 homolog (S. cerevisiae)
| |
Aliases
for MND1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Meiotic Nuclear Divisions 1 Homolog (S. Cerevisiae)1 2 | | GAJ1 2 3 | | Homolog Of Yeast MND12 | | Meiotic Nuclear Division Protein 1 Homolog2 |
Export aliases for MND1 gene to outside databasesPrevious GC identifers: GC04P154485 GC04P149996 |
Summaries
for MND1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MND1:
The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNAand stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 (PubMed17639080)). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: MND1_HUMAN, Q9BWT6Function: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombinationduring meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which isrequired for the resolution of meiotic double-strand breaks
|
Genomic Views
for MND1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MND1 gene promoter:
POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) Nkx2-5 POU3F2 FOXL1 C/EBPalpha FOXI1 POU2F1 POU2F1a ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for MND1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MND1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q31.3 Ensembl cytogenetic band: 4q31.3 HGNC cytogenetic band: 4q31.3MND1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P154265: view genomic region
(about GC identifiers)
Start:
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154,265,801 bp from pter |
End:
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154,336,270 bp from pter |
Size:
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70,470 bases |
Orientation:
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plus strand |
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Proteins
for MND1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MND1_HUMAN, Q9BWT6 (See
protein sequence)Recommended Name: Meiotic nuclear division protein 1 homolog Size: 205 amino acids; 23753 Da
Subunit: Heterodimer with PSMC3IP/HOP2. MND1-PSMC3IP interacts with DMC1 and RAD51 and binds preferentially to dsDNA
Subcellular location: Nucleus (Probable)
Secondary accessions: B2R5F9Explore the universe of human proteins at neXtProt for MND1: NX_Q9BWT6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BWT6
MND1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001240790.1 NP_115493.1
ENSEMBL proteins: ENSP00000240488 ENSP00000427559 ENSP00000425500 ENSP00000422933
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
MND1 for ontologies About GeneDecksing
MND1 Antibody Products:
Assay Products for MND1: |
Protein
Domains /
Families
for MND1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MND1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BWT6ProtoNet protein and cluster: Q9BWT6 UniProtKB/Swiss-Prot: MND1_HUMAN, Q9BWT6Similarity: Belongs to the MND1 family |
Function
for MND1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MND1_HUMAN, Q9BWT6Function: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombinationduring meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which isrequired for the resolution of meiotic double-strand breaks
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MND1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MND1 (NM_017909) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MND1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MND1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MND1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
MND1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MND1:
|
Pathways & Interactions
for MND1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MND1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/13 Interacting proteins for MND1 (Q9BWT63 ENSP000002404884) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
MND1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MND1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MND1
Search CenterWatch for drugs/clinical trials and news about MND1
|
Transcripts
for MND1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MND1 gene (2 alternative transcripts): NM_001253861.1 NM_032117.3 Unigene Cluster for MND1: Meiotic nuclear divisions 1 homolog (S. cerevisiae) Hs.294088 [show with all ESTs]Unigene Representative Sequence: NR_0456055 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000240488(uc021xtj.1 uc003ink.2 uc021xtk.1) ENST00000503967
ENST00000509752 ENST00000508731 ENST00000504860
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MND1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MND1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MND1 (NM_017909) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MND1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MND1 |
Additional cDNA sequence: AK312172.1 AY028916.1 BC032142.2 NR_045605.1 6 DOTS entries: DT.304361 DT.100023230 DT.91759897 DT.102822471 DT.95184333 DT.95184334 24/43 AceView cDNA sequences (see all 43): AY028916 BE879584 NM_032117 CA430591 BG109991 BM833450 BU622320 AA971073 BU935172 BM741097 BG685476 BG190562 BM821505 BE513408 BX118316 CD248060 BG758047 BQ888320 BG211199 BQ876910 BF975093 BG613292 BM822584 AA782986
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for MND1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | - | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MND1
|
Expression
for MND1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MND1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGTGAAGG
About this image
See MND1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MND1
SOURCE GeneReport for Unigene cluster: Hs.294088
SABiosciences Custom PCR Arrays for MND1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MND1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MND1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MND1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MND1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MND1 |
Orthologs
for MND1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MND1 gene from 8/27 species (see all 27) About this table
ENSEMBL Gene Tree for MND1 (if available)
TreeFam Gene Tree for MND1 (if available) |
Paralogs
for MND1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MND1 gene
MND1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MND1
PGOHUM00000244799
|
Genomic Variants
for MND1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MND1 |
|
Disorders
/ Diseases
for MND1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MND1 for disorders About GeneDecksing
OMIM gene information: 611422
OMIM disorders: --
1  disease for MND1: About MalaCardsmalaria
1 disease from the University of Copenhagen DISEASES database for MND1:Developmental coordination disorder Human Genome Epidemiology (HuGE) Navigator: MND1 (2 documents)
Export disorders for MND1 gene to outside databases
|
Publications
for MND1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MND1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with MND1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Stimulation of DNA strand exchange by the human TBPIP/Hop2-Mnd1 complex. (PubMed id 16407260)1, 2 Enomoto R....Yokoyama S. (2006)
- The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair. (PubMed id 11940665)1, 3 Tsubouchi H. and Roeder G.S. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase. (PubMed id 17639080)1 Chi P....Sung P. (2007)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for MND1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MND1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MND1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MND1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MND1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MND1 gene:
Search GeneIP for patents involving MND1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MND1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MND1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MND1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MND1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MND1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MND1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MND1 |
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 | | | MND1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MND1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MND1 |
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