Aliases for MNAT1 Gene
External Ids for MNAT1 Gene
Previous GeneCards Identifiers for MNAT1 Gene
The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for MNAT1 Gene
MNAT1 (MNAT1, CDK Activating Kinase Assembly Factor) is a Protein Coding gene. Diseases associated with MNAT1 include Urethritis. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include protein N-terminus binding and RNA polymerase II carboxy-terminal domain kinase activity.
UniProtKB/Swiss-Prot for MNAT1 Gene
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.