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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MN1 Gene

protein-coding GIFtS: 50
GCID: GC22M028144

meningioma (disrupted in balanced translocation) 1

(Previous name: meningioma chromosome region )
(Previous symbol: MGCR)

Explore 14 diseases affiliated with
MN1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Meningioma (Disrupted In Balanced Translocation) 1¹ ²		DJ353E16.2¹
MGCR¹ ² ⁵		Meningioma (Translocation Balanced)²
MGCR1¹ ²		Meningioma Chromosome Region 1²
MGCR1-PEN¹ ²		Probable Tumor Suppressor Protein MN1²
Meningioma Chromosome Region¹

External Ids:	HGNC: 7180¹	Entrez Gene: 4330²	Ensembl: ENSG00000169184⁷	OMIM: 156100⁵	UniProtKB: Q10571³

Export aliases for MN1 gene to outside databases

Previous GC identifers: GC22M024840 GC22M026468 GC22M011108

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MN1:

Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a

meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MN1_HUMAN, Q10571

Function: May play a role in tumor suppression

Gene Wiki entry for MN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MN1 gene promoter:
RP58 Pax-5 AP-2gamma Roaz AREB6 AP-2beta SEF-1 (1) AP-2alpha Meis-1 AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MN1 promoter sequence

Search SABiosciences Chromatin IP Primers for MN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.1 Ensembl cytogenetic band: 22q12.1 HGNC cytogenetic band: 22q12.1

MN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MN1 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M028144: view genomic region (about GC identifiers)

Start:	28,144,265 bp from pter	End:	28,197,486 bp from pter
Size:	53,222 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MN1_HUMAN, Q10571 (See protein sequence)

Recommended Name: Probable tumor suppressor protein MN1

Size: 1320 amino acids; 136001 Da

Secondary accessions: A9Z1V9

Explore the universe of human proteins at neXtProt for MN1: NX_Q10571

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q10571

MN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002421.3

ENSEMBL proteins:

ENSP00000304956 ENSP00000397805

Human Recombinant Protein Products for MN1:

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	GenScript Custom Purified and Recombinant Proteins Services for MN1
	Novus Biologicals MN1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MN1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

MN1 for ontologies About GeneDecksing

MN1 Antibody Products:

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Assay Products for MN1:

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	GenScript Custom Assay Services for MN1
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	Uscn ELISAs and CLIAs for MN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q10571

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MN1_HUMAN, Q10571

Function: May play a role in tumor suppression

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

MN1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for MN1:

Synthetic lethal with Ras

8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mn1):

behavior/neurological	craniofacial	digestive/alimentary	homeostasis/metabolism	mortality/aging
respiratory system	skeleton	tumorigenesis

MN1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Mn1^tm1Ecz for MN1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MN1

miRNA Products:		OriGene 3'-UTR Clone: MN1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MN1
		8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate MN1 (see all 77):
		hsa-miR-26a-2* hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-128 hsa-miR-200a hsa-miR-371-5p hsa-miR-550a*

		SwitchGear 3'UTR luciferase reporter plasmid: MN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MN1 (see all 4) OriGene shRNA RFP: MN1 OriGene siRNA: MN1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against MN1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MN1
			Sirion Biotech Customized adenovirus for overexpression of MN1 Sirion Biotech Customized adenovirus for potent knockdown of MN1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MN1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MN1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): MN1 (NM_005563)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MN1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MN1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MN1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for MN1 (Q10571^{2, 3} ENSP00000304956⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EP300	Q09472³, ENSP00000263253⁴	I2D: score=1 STRING: ENSP00000263253
--	P31016²	MINT-8108680

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001957	intramembranous ossification	IEA	--
GO:0008150	biological_process	ND	--

MN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MN1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MN1
1 Novoseek chemical compound relationship for MN1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid	46	13	18632758 (4), 17242174 (2)

Search CenterWatch for drugs/clinical trials and news about MN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MN1 gene:

NM_002430.2

Unigene Cluster for MN1:

Meningioma (disrupted in balanced translocation) 1

Hs.268515 [show with all ESTs]

Unigene Representative Sequence: NM_002430

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000302326(uc010gvg.3 uc003adj.3) ENST00000424656 ENST00000497225

miRNA Products:		OriGene 3'-UTR Clone: MN1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MN1
		8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate MN1 (see all 77):
		hsa-miR-26a-2* hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-128 hsa-miR-200a hsa-miR-371-5p hsa-miR-550a*

		SwitchGear 3'UTR luciferase reporter plasmid: MN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MN1 (see all 4) OriGene shRNA RFP: MN1 OriGene siRNA: MN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MN1
		Sirion Biotech Custom design and validation of potent shRNA sequences against MN1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MN1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MN1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): MN1 (NM_005563)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MN1
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MN1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MN1

Additional cDNA sequence:

AK307152.1 X82209.2 Z70218.1

3 DOTS entries:

DT.313671 DT.120648456 DT.95157898

24/61 AceView cDNA sequences (see all 61):

BQ446922 CB132163 AA340204 BM927002 BQ067881 AL134518 BM821195 AU118290

BQ017335 AA339316 AI338832 Z28469 BG059788 BE045553 NM_002430 BI914686

D51800 D59763 BF433623 BF530976 AU117972 BI497169 AA340193 X82209

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTGAGTG

About this image

MN1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10 LifeMap Cells

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

See MN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MN1

SOURCE GeneReport for Unigene cluster: Hs.268515

UniProtKB/Swiss-Prot: MN1_HUMAN, Q10571

Tissue specificity: Ubiquitously expressed. Highest levels in skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Array including MN1:

Leukemia in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MN1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MN1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MN1 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Mn1^{1 , 5}	meningioma 1^{1, 5}	85.81(n)¹ 91.21(a)¹	5 (53.86 cM)⁵ 433938¹ NM_001081235.1¹ NP_001074704.1¹ 111417362⁵
tropical clawed frog (Xenopus tropicalis)	Amphibia	137723142²	--	84.16(n)	137723142
zebrafish (Danio rerio)	Actinopterygii	mn1b¹	meningioma 1b	62.01(n) 59.93(a)	572077 XM_001919740.3 XP_001919775.2

ENSEMBL Gene Tree for MN1 (if available)
TreeFam Gene Tree for MN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145989801^1,2		--	28143907(+)	`GGATCA/TTTCCC`	1	--	ds500¹		0	--	--	--	--
rs45454497^1,2	C	--	28143953(-)	`AAAAAA/CAAAAA`	1	--	ds500¹		5		NS	172
rs139877526^1,2		--	28144085(+)	`AGAAAC/TACTGA`	1	--	ds500¹		0	--	--	--	--
rs77077403^1,2	C	--	28144110(+)	`GAACAG/TCAACA`	1	--	ds500¹		0	--	--	--	--
rs141191948^1,2		--	28144125(+)	`CACAG-/ACACACA`	1	--	ds500¹		0	--	--	--	--
rs9608646^1,2	H	--	28144184(+)	`CATAGA/GATCTG`	1	--	ds500¹		4		NS EA	420
rs45527237^1,2	C,F	--	28144225(-)	`TGTTT-/TCCTCC`	1	--	ds500¹		6		NS CSA	126
rs189741873^1,2		--	28144269(+)	`GTCACA/CATTAA`	1	--	ut3¹		0	--	--	--	--
rs181742570^1,2		--	28144352(+)	`ACTGCA/GCTTTA`	1	--	ut3¹		0	--	--	--	--
rs3216407^1,2	C	--	28144380(+)	`GAAAG-/AAAAAA`	1	--	ut3¹ trp³		0	--	--	--	--

HapMap Linkage Disequilibrium report for MN1 (28144265 - 28197486 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MN1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MN1

DNA2.0 Custom Variant and Variant Library Synthesis for MN1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MN1 for disorders           About GeneDecksing

OMIM gene information: 156100
OMIM disorders: 607174
UniProtKB/Swiss-Prot: MN1_HUMAN, Q10571

Note=A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation

t(12;22)(p13;q11) with TEL

Note=Defects in MN1 involved in the development of meningiomas, slowly growing benign tumors derived from the

arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed

to be the most common primary tumors of the central nervous system in man

14 diseases for MN1: About MalaCards

meningioma arachnoiditis acute myeloid leukemia myeloproliferative disorder

urethral syndrome myeloid leukemia benign tumors myelodysplastic syndrome

leukemia conjunctivitis acute leukemia hematopoiesis

t-cell leukemia anemia

1 disease from the University of Copenhagen DISEASES database for MN1:

Acute myeloid leukemia

4 Novoseek disease relationships for MN1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
meningioma	68.3	5	7731706 (3), 18632758 (1), 17242174 (1)
chromosomal aberrations	45.9	1	17335728 (1)
leukemia	31.9	1	18632758 (1)
tumors	0	2	16398473 (1), 17335728 (1)

Human Genome Epidemiology (HuGE) Navigator: MN1 (3 documents)

Export disorders for MN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MN1 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with MN1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma. (PubMed id 7731706)^{1, 2, 3, 9} Deprez R.H.L.... Zwarthoff E.C. (1995)
The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription. (PubMed id 12569362)^{1, 3} van Wely K.H....Zwarthoff E.C. (2003)
MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression. (PubMed id 18632758)^{1, 9} Meester-Smoor M.A....Zwarthoff E.C. (2008)
The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence. (PubMed id 17242174)^{1, 9} Meester-Smoor M.A....Zwarthoff E.C. (2007)
Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. (PubMed id 7731705)^{1, 9} Buijs A....Hagemeijer A. (1995)
Genetic and environmental risk factors for submucous c left palate. (PubMed id 22409215)¹ Reiter R....Maier C. (2012)
Prognostic significance of combined MN1, ERG, BAALC, a nd EVI1 (MEBE) expression in patients with myelodysplastic syndromes. (PubMed id 22488406)¹ Thol F....Heuser M. (2012)
A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)¹ Tao S....Sun J. (2012)
Overexpression of MN1 confers resistance to chemothera py, accelerates leukemia onset, and suppresses p53 and Bim induction. (PubMed id 22905229)¹ Pardee T.S. (2012)
MN1-ETV6 fusion gene arising from MDS with 5q-. (PubMed id 21600651)¹ Nofrini V....Mecucci C. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4330	HGNC: 7180	AceView: MN1	Ensembl:ENSG00000169184	euGenes: HUgn4330
ECgene: MN1	H-InvDB: MN1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MN1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MN1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MN1 gene:
Search GeneIP for patents involving MN1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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MN1 Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MN1

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Sirion Biotech Customized:

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MN1 Gene

meningioma (disrupted in balanced translocation) 1

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MN1 Gene

meningioma (disrupted in balanced translocation) 1

Aliasesfor MN1 gene

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Pathways & Interactionsfor MN1 gene

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Specialized Databases showing MN1 gene

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Summaries
for MN1 gene

Genomic Views
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for MN1 gene

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for MN1 gene

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for MN1 gene

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for MN1 gene

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for MN1 gene

Expression
for MN1 gene

Orthologs
for MN1 gene

Paralogs
for MN1 gene

Genomic Variants
for MN1 gene

Disorders / Diseases
for MN1 gene

Publications
for MN1 gene

Intellectual Property
for MN1 gene

Products
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