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MN1 Gene

protein-coding   GIFtS: 52
GCID: GC22M028144

Meningioma (Disrupted In Balanced Translocation) 1

(Previous name: meningioma chromosome region)
(Previous symbol: MGCR)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Meningioma (Disrupted In Balanced Translocation) 11 2     MGCR1-PEN2
MGCR1 2 5     dJ353E16.22
Probable Tumor Suppressor Protein MN11 2     Meningioma (Translocation Balanced)2
Meningioma Chromosome Region1     Meningioma Chromosome Region 12
MGCR12     

External Ids:    HGNC: 71801   Entrez Gene: 43302   Ensembl: ENSG000001691847   OMIM: 1561005   UniProtKB: Q105713   

Export aliases for MN1 gene to outside databases

Previous GC identifers: GC22M024840 GC22M026468 GC22M011108


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MN1 Gene:
Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a
meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for MN1 Gene:
MN1 (meningioma (disrupted in balanced translocation) 1) is a protein-coding gene. Diseases associated with MN1 include meningioma, and urethral syndrome.

UniProtKB/Swiss-Prot: MN1_HUMAN, Q10571
Function: May play a role in tumor suppression

Gene Wiki entry for MN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MN1 gene promoter:
         RP58   Pax-5   AP-2gamma   Roaz   AREB6   AP-2beta   SEF-1 (1)   AP-2alpha   Meis-1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MN1 promoter sequence
   Search Chromatin IP Primers for MN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.1   Ensembl cytogenetic band:  22q12.1   HGNC cytogenetic band: 22q12.1

MN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MN1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M028144:  view genomic region     (about GC identifiers)

Start:
28,144,265 bp from pter      End:
28,197,486 bp from pter
Size:
53,222 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MN1_HUMAN, Q10571 (See protein sequence)
Recommended Name: Probable tumor suppressor protein MN1  
Size: 1320 amino acids; 136001 Da
Secondary accessions: A9Z1V9

Explore the universe of human proteins at neXtProt for MN1: NX_Q10571

Explore proteomics data for MN1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002421.3  
    ENSEMBL proteins: 
     ENSP00000304956   ENSP00000397805  

    MN1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MN1
    GenScript Custom Purified and Recombinant Proteins Services for MN1
    Novus Biologicals MN1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MN1

    MN1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MN1
    OriGene Custom Antibody Services for MN1
    Novus Biologicals MN1 Antibodies
    Abcam antibodies for MN1
    Cloud-Clone Corp. Antibodies for MN1
    Search ThermoFisher Antibodies for MN1
    LSBio Antibodies in human, mouse, rat for MN1

    MN1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MN1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MN1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MN1
    Cloud-Clone Corp. CLIAs for MN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q10571


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MN1_HUMAN, Q10571
    Function: May play a role in tumor suppression

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    MN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MN1:
     Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mn1):
     behavior/neurological  craniofacial  digestive/alimentary  homeostasis/metabolism  mortality/aging 
     respiratory system  skeleton  tumorigenesis 

    MN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mn1tm1Ecz for MN1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MN1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MN1:
    hsa-mir-9-5p (MIRT021439), hsa-mir-335-5p (MIRT018049)

    Block miRNA regulation of human, mouse, rat MN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MN1 (see all 77):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-128 hsa-miR-200a hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidMN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MN1
    Predesigned siRNA for gene silencing in human, mouse, rat MN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MN1

    Clone
    Products:
         
    OriGene clones in human, mouse for MN1 (see all 6)
    OriGene ORF clones in mouse, rat for MN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MN1 (NM_005563)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MN1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MN1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MN1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    MN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including MN1: 
              Leukemia in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MN1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for MN1 (Q105712, 3 ENSP000003049564) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    --P310162MINT-8108680
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001957intramembranous ossification IEA--
    GO:0008150biological_process ND--

    MN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MN1

    1 Novoseek inferred chemical compound relationship for MN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 46 13 18632758 (4), 17242174 (2)



    MN1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MN1 gene: 
    NM_002430.2  

    Unigene Cluster for MN1:

    Meningioma (disrupted in balanced translocation) 1
    Hs.268515  [show with all ESTs]
    Unigene Representative Sequence: NM_002430
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302326(uc010gvg.3 uc003adj.3) ENST00000424656 ENST00000497225

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MN1 (see all 77):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-128 hsa-miR-200a hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidMN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MN1
    Predesigned siRNA for gene silencing in human, mouse, rat MN1
    Clone
    Products:
         
    OriGene clones in human, mouse for MN1 (see all 6)
    OriGene ORF clones in mouse, rat for MN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MN1 (NM_005563)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MN1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MN1
      QuantiTect SYBR Green Assays in human, mouse, rat MN1
      QuantiFast Probe-based Assays in human, mouse, rat MN1

    Additional mRNA sequence: 

    AK307152.1 X82209.2 Z70218.1 

    3 DOTS entries:

    DT.313671  DT.120648456  DT.95157898 

    Selected AceView cDNA sequences (see all 61):

    BQ446922 CB132163 AA340204 BF530976 AA340193 X82209 D51800 D59763 
    BF433623 BM927002 BQ017335 BI914686 CF264930 AI277624 BQ067881 AA339316 
    AL134518 BU158459 BG059788 BI497169 Z39850 AU118290 Z28469 AU117972 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MN1 expression in normal human tissues (normalized intensities)      MN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTGAGTG
    MN1 Expression
    About this image


    MN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    MN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.268515

    UniProtKB/Swiss-Prot: MN1_HUMAN, Q10571
    Tissue specificity: Ubiquitously expressed. Highest levels in skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including MN1: 
              Leukemia in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MN1
    QuantiTect SYBR Green Assays in human, mouse, rat MN1
    QuantiFast Probe-based Assays in human, mouse, rat MN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MN1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mn11 , 5 meningioma 11, 5 85.3(n)1
    90.52(a)1
      5 (53.86 cM)5
    4339381  NM_001081235.11  NP_001074704.11 
     1114173625 
    chicken
    (Gallus gallus)
    Aves MN16
    meningioma (disrupted in balanced translocation) 1...
    72(a)
    1 ↔ 1
    15(7488965-7521455)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377231422   -- 84.16(n)    137723142 
    zebrafish
    (Danio rerio)
    Actinopterygii mn1b1 meningioma 1b 61.16(n)
    58.26(a)
      572077  XM_001919740.4  XP_001919775.2 


    ENSEMBL Gene Tree for MN1 (if available)
    TreeFam Gene Tree for MN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MN1 (see all 1221)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1459898011,2
    --12065043(+) GGATCA/TTTCCC 1 -- ds50010--------
    rs454544971,2
    C--12065089(-) AAAAAA/CAAAAA 1 -- ds50015Minor allele frequency- C:0.01NS 172
    rs1398775261,2
    --12065221(+) AGAAAC/TACTGA 1 -- ds50010--------
    rs770774031,2
    C--12065246(+) GAACAG/TCAACA 1 -- ds50010--------
    rs1411919481,2
    --12065261(+) CACAG-/ACACACA 1 -- ds50010--------
    rs96086461,2
    H--12065320(+) CATAGA/GATCTG 1 -- ds50014Minor allele frequency- G:0.00NS EA 420
    rs455272371,2
    C,F--12065361(-) CTTTG-/TTTTCC 1 -- ds50016Minor allele frequency- T:0.08NS CSA 126
    rs1897418731,2
    --12065405(+) GTCACA/CATTAA 1 -- ut310--------
    rs1817425701,2
    --12065488(+) ACTGCA/GCTTTA 1 -- ut310--------
    rs60056061,2
    H--12065603(+) AAAAAG/AATTAC 1 -- ut314Minor allele frequency- A:0.00NS EA 418

    HapMap Linkage Disequilibrium report for MN1 (28144265 - 28197486 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724116CNV Deletion23290073
    esv2675305CNV Deletion23128226
    esv2056669CNV Deletion18987734
    esv2210205CNV Deletion18987734
    nsv829146CNV Gain20364138
    nsv518700CNV Gain19592680
    nsv829144CNV Gain20364138
    nsv829145CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MN1
    DNA2.0 Custom Variant and Variant Library Synthesis for MN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 156100   
    OMIM disorders: 607174  
    UniProtKB/Swiss-Prot: MN1_HUMAN, Q10571
  • Note=A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation
    t(12;22)(p13;q11) with TEL
  • Note=Defects in MN1 involved in the development of meningiomas, slowly growing benign tumors derived from
    the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are
    believed to be the most common primary tumors of the central nervous system in man

  • Selected diseases for MN1 (see all 21):    About MalaCards
    meningioma    urethral syndrome    refractory anemia with excess blasts    cytogenetically normal acute myeloid leukemia
    mn1    refractory anemia    arachnoiditis    urethritis
    myeloproliferative disorder    acute myeloid leukemia    conjunctivitis    myelodysplastic syndromes
    cleft palate    acute leukemia    myeloid leukemia    t-cell leukemia
    leukemia    multiple myeloma    myeloma    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for MN1:
    Leukemia

    MN1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for MN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    meningioma 68.3 5 7731706 (3), 18632758 (1), 17242174 (1)
    chromosomal aberrations 45.9 1 17335728 (1)
    leukemia 31.9 1 18632758 (1)
    tumors 0 2 16398473 (1), 17335728 (1)

    Genetic Association Database (GAD): MN1
    Human Genome Epidemiology (HuGE) Navigator: MN1 (3 documents)

    Export disorders for MN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MN1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with MN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma. (PubMed id 7731706)1, 2, 3, 9 Deprez R.H.L.... Zwarthoff E.C. (Oncogene 1995)
    2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    3. The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription. (PubMed id 12569362)1, 3 van Wely K.H....Zwarthoff E.C. (Oncogene 2003)
    4. MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression. (PubMed id 18632758)1, 9 Meester-Smoor M.A....Zwarthoff E.C. (Carcinogenesis 2008)
    5. The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence. (PubMed id 17242174)1, 9 Meester-Smoor M.A....Zwarthoff E.C. (J. Mol. Endocrinol. 2007)
    6. Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. (PubMed id 7731705)1, 9 Buijs A....Hagemeijer A. (Oncogene 1995)
    7. The clinical characteristics and prognostic significance of MN1 gene and MN1-associated microRNA expression in adult patients with de novo acute myeloid leukemia. (PubMed id 23515710)1 Xiang L....Gu W. (Ann. Hematol. 2013)
    8. Genetic and environmental risk factors for submucous cleft palate. (PubMed id 22409215)1 Reiter R....Maier C. (Eur. J. Oral Sci. 2012)
    9. Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes. (PubMed id 22488406)1 Thol F....Heuser M. (Ann. Hematol. 2012)
    10. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (Carcinogenesis 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4330 HGNC: 7180 AceView: MN1 Ensembl:ENSG00000169184 euGenes: HUgn4330
    ECgene: MN1 H-InvDB: MN1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for MN1 gene:
    Search GeneIP for patents involving MN1

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